SPDEF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.04961157
2digestion (GO:0007586)8.42425245
3exocrine pancreas development (GO:0031017)7.61103129
4intestinal absorption (GO:0050892)7.32348041
5UDP-N-acetylglucosamine metabolic process (GO:0006047)7.12461176
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.99581553
7protein retention in ER lumen (GO:0006621)6.95081709
8ear development (GO:0043583)6.47264645
9regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.39187265
10epithelial cell maturation (GO:0002070)6.04809018
11maintenance of gastrointestinal epithelium (GO:0030277)5.90821614
12transcytosis (GO:0045056)5.86240702
13uterus development (GO:0060065)5.67459532
14pyrimidine-containing compound transmembrane transport (GO:0072531)5.43776249
15endothelial cell chemotaxis (GO:0035767)5.40604444
16vagina development (GO:0060068)5.25302792
17negative regulation of cell size (GO:0045792)5.19632280
18positive regulation of keratinocyte differentiation (GO:0045618)5.07012627
19biotin metabolic process (GO:0006768)5.04802950
20Golgi transport vesicle coating (GO:0048200)4.90566359
21COPI coating of Golgi vesicle (GO:0048205)4.90566359
22GDP-mannose metabolic process (GO:0019673)4.81950126
23O-glycan processing (GO:0016266)4.74333392
24galactose catabolic process (GO:0019388)4.65773640
25branching involved in mammary gland duct morphogenesis (GO:0060444)4.65395229
26sulfur amino acid catabolic process (GO:0000098)4.64790008
27epithelial structure maintenance (GO:0010669)4.63378883
28bile acid and bile salt transport (GO:0015721)4.62211979
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.62104879
30regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.61529631
31intracellular estrogen receptor signaling pathway (GO:0030520)4.56302182
32* lung secretory cell differentiation (GO:0061140)4.51390444
33regulation of cell proliferation involved in kidney development (GO:1901722)4.43379695
34digestive system process (GO:0022600)4.42109915
35maternal placenta development (GO:0001893)4.41298087
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.40616321
37negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.35423888
38sulfation (GO:0051923)4.26873778
39nucleotide-sugar biosynthetic process (GO:0009226)4.26684595
40branching involved in prostate gland morphogenesis (GO:0060442)4.25803284
41positive regulation of cellular amine metabolic process (GO:0033240)4.23260429
42peptidyl-tyrosine autophosphorylation (GO:0038083)4.22319192
43nucleotide-sugar metabolic process (GO:0009225)4.16587400
44cobalamin metabolic process (GO:0009235)4.15309790
45female genitalia development (GO:0030540)4.14143936
46positive regulation of Cdc42 GTPase activity (GO:0043089)4.12792547
47regulation of histone H3-K27 methylation (GO:0061085)4.10723358
48positive regulation of epidermal cell differentiation (GO:0045606)4.04361420
49prostate gland epithelium morphogenesis (GO:0060740)4.03279510
50mitochondrial calcium ion transport (GO:0006851)4.02603195
51antibacterial humoral response (GO:0019731)4.00873465
52regulation of water loss via skin (GO:0033561)4.00014877
53phosphatidylserine acyl-chain remodeling (GO:0036150)3.99137291
54angiotensin maturation (GO:0002003)3.96048182
55cysteine metabolic process (GO:0006534)3.95037842
56interferon-gamma secretion (GO:0072643)3.94025760
57semaphorin-plexin signaling pathway (GO:0071526)3.91837521
58amyloid precursor protein catabolic process (GO:0042987)3.86865687
59regulation of fatty acid beta-oxidation (GO:0031998)3.86039955
60phosphatidylinositol acyl-chain remodeling (GO:0036149)3.85338187
61mucosal immune response (GO:0002385)3.80208389
62epithelial cell differentiation involved in prostate gland development (GO:0060742)3.79409147
63zinc ion transport (GO:0006829)3.79375781
64antimicrobial humoral response (GO:0019730)3.77587010
65N-glycan processing (GO:0006491)3.77075699
66peptidyl-proline hydroxylation (GO:0019511)3.75648738
67positive regulation of nitric-oxide synthase activity (GO:0051000)3.75532047
68L-fucose catabolic process (GO:0042355)3.72911653
69fucose catabolic process (GO:0019317)3.72911653
70L-fucose metabolic process (GO:0042354)3.72911653
71norepinephrine metabolic process (GO:0042415)3.69638151
72valine metabolic process (GO:0006573)3.68842454
73activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.68100544
74negative regulation of digestive system process (GO:0060457)3.64303295
75prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.63793039
76ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.60129482
77organ or tissue specific immune response (GO:0002251)3.58988375
78galactose metabolic process (GO:0006012)3.57662767
79proline biosynthetic process (GO:0006561)3.56181536
80response to food (GO:0032094)3.51474918
81phosphatidylserine metabolic process (GO:0006658)3.51281177
82negative regulation of fatty acid transport (GO:2000192)3.49401517
83mammary gland alveolus development (GO:0060749)3.49126119
84proline metabolic process (GO:0006560)3.49029351
85positive regulation of nuclease activity (GO:0032075)3.46871361
86insulin-like growth factor receptor signaling pathway (GO:0048009)3.45823957
87regulation of interleukin-13 production (GO:0032656)3.44918489
88regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43857054
89homocysteine metabolic process (GO:0050667)3.43103932
90mammary gland epithelial cell differentiation (GO:0060644)3.42342291
91regulation of establishment or maintenance of cell polarity (GO:0032878)3.41639698
92response to endoplasmic reticulum stress (GO:0034976)3.40074232
93COPII vesicle coating (GO:0048208)3.38167779
94cardiac right ventricle morphogenesis (GO:0003215)3.34663701
95* intestinal epithelial cell development (GO:0060576)3.34542660
96protein N-linked glycosylation via asparagine (GO:0018279)3.34213957
97peptidyl-asparagine modification (GO:0018196)3.34157984
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.33689692
99epithelial cell-cell adhesion (GO:0090136)3.33535186
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.32694245
101purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.32694245
102vitamin transmembrane transport (GO:0035461)3.31969140
103embryonic camera-type eye morphogenesis (GO:0048596)3.31101812
104signal peptide processing (GO:0006465)3.29554120
105protein O-linked glycosylation (GO:0006493)3.27351291
106myelin maintenance (GO:0043217)3.27341219
107apical protein localization (GO:0045176)3.26125918
108embryonic eye morphogenesis (GO:0048048)3.23881230
109primary alcohol catabolic process (GO:0034310)3.23637944
110peptide catabolic process (GO:0043171)3.23501660
111activation of Rac GTPase activity (GO:0032863)3.20659420
112leukotriene biosynthetic process (GO:0019370)3.19342510
113purine nucleotide transport (GO:0015865)3.19032570
114nucleotide transmembrane transport (GO:1901679)3.18731013
115endoplasmic reticulum unfolded protein response (GO:0030968)3.18626209
116sulfate transmembrane transport (GO:1902358)3.18017426
117regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.16043221
118fucose metabolic process (GO:0006004)3.14994391
119branched-chain amino acid catabolic process (GO:0009083)3.12879015
120sulfur compound transport (GO:0072348)3.12303526
121regulation of cholesterol biosynthetic process (GO:0045540)3.12226637
122mesonephros development (GO:0001823)3.10945879
123protein N-linked glycosylation (GO:0006487)3.10189034
124regulation of nuclease activity (GO:0032069)3.09228863
125hepatocyte apoptotic process (GO:0097284)3.09185279
126cellular modified amino acid catabolic process (GO:0042219)3.09140165
127regulation of autophagic vacuole assembly (GO:2000785)3.08553072
128regulation of receptor binding (GO:1900120)3.06668278
129cellular response to unfolded protein (GO:0034620)3.06655896
130pharyngeal system development (GO:0060037)3.05256953
131protein hydroxylation (GO:0018126)3.05137855
132multicellular organismal water homeostasis (GO:0050891)3.02728006
133positive regulation of hormone metabolic process (GO:0032352)3.02535045
134regulation of keratinocyte differentiation (GO:0045616)3.02328652
135regulation of establishment of cell polarity (GO:2000114)3.01525656
136carnitine shuttle (GO:0006853)3.01402666
137innate immune response in mucosa (GO:0002227)3.01378717
138ruffle organization (GO:0031529)2.96951594
139regulation of phospholipase A2 activity (GO:0032429)2.96257502
140vitamin A metabolic process (GO:0006776)2.95626688
141phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.95530952
142nitric oxide biosynthetic process (GO:0006809)2.94171384
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93791472
144branched-chain amino acid metabolic process (GO:0009081)2.93631073
145asymmetric protein localization (GO:0008105)2.93611760
146low-density lipoprotein particle remodeling (GO:0034374)2.93162226
147ER-nucleus signaling pathway (GO:0006984)2.91318114
148establishment of skin barrier (GO:0061436)2.89993264
149positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.89392491
150prostate gland growth (GO:0060736)2.87446897
151* glandular epithelial cell differentiation (GO:0002067)2.86250317
152purine ribonucleotide transport (GO:0015868)2.85241153
153cellular response to topologically incorrect protein (GO:0035967)2.84869672
154mammary gland epithelial cell proliferation (GO:0033598)2.84354714
155regulation of actin nucleation (GO:0051125)2.82967168
156hexose catabolic process (GO:0019320)2.81873851
157iron ion import (GO:0097286)2.81683159
158glucose 6-phosphate metabolic process (GO:0051156)2.81014475
159endocrine hormone secretion (GO:0060986)2.80571584
160carnitine transmembrane transport (GO:1902603)2.80189920
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.76417709
162actin filament depolymerization (GO:0030042)2.76398061
163mannose metabolic process (GO:0006013)2.76312933
164cell-cell junction maintenance (GO:0045217)2.76005277
165creatine metabolic process (GO:0006600)2.75861049
166alditol phosphate metabolic process (GO:0052646)2.75188775
167protein maturation by protein folding (GO:0022417)2.74991631
168glucosamine-containing compound metabolic process (GO:1901071)2.73482913
169cellular response to interferon-alpha (GO:0035457)2.72102898
170establishment of apical/basal cell polarity (GO:0035089)2.71130181
171intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.70446023
172positive regulation of growth hormone secretion (GO:0060124)2.69389390
173amino sugar metabolic process (GO:0006040)2.69303093
174amyloid precursor protein metabolic process (GO:0042982)2.69092944
175desmosome organization (GO:0002934)2.68840905
176hemidesmosome assembly (GO:0031581)2.68636102
177positive regulation of epidermis development (GO:0045684)2.67739433
178negative regulation of kidney development (GO:0090185)2.66761643
1794-hydroxyproline metabolic process (GO:0019471)2.66070422
180chemical homeostasis within a tissue (GO:0048875)2.66057425
181negative regulation of keratinocyte proliferation (GO:0010839)2.65596848
182carnitine transport (GO:0015879)2.65471376
183amino-acid betaine transport (GO:0015838)2.65471376
184regulation of interleukin-5 production (GO:0032674)2.64571112
185trivalent inorganic anion homeostasis (GO:0072506)2.63759518
186phosphate ion homeostasis (GO:0055062)2.63759518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.28846827
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.24584851
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.13143461
4GATA4_25053715_ChIP-Seq_YYC3_Human3.19828830
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10867821
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.06283324
7GATA6_25053715_ChIP-Seq_YYC3_Human2.97665882
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.92102485
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87889110
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79327523
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.79155027
12* SOX2_20726797_ChIP-Seq_SW620_Human2.79098990
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.51406604
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30401097
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27858266
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27587524
17* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.26174479
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25685875
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.14850082
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06892222
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06892222
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06892222
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03719166
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.95391930
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.91087162
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.90955364
27* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84925223
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.83778711
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83629252
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78959577
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77957777
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77642394
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76209842
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76145497
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.75589808
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.75543989
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.74042564
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71852173
39* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70103404
40KLF5_25053715_ChIP-Seq_YYC3_Human1.69776603
41RACK7_27058665_Chip-Seq_MCF-7_Human1.67678279
42TCF7_22412390_ChIP-Seq_EML_Mouse1.67347750
43* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.66434186
44VDR_21846776_ChIP-Seq_THP-1_Human1.64506140
45KDM5A_27292631_Chip-Seq_BREAST_Human1.62981381
46* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.60728853
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57515507
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.57213447
49MYC_22102868_ChIP-Seq_BL_Human1.56435664
50ZNF263_19887448_ChIP-Seq_K562_Human1.56087132
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55989872
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51241268
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50761914
54AR_21909140_ChIP-Seq_LNCAP_Human1.49136635
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48317081
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43448450
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43383072
58CREB1_26743006_Chip-Seq_LNCaP_Human1.41372939
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40108893
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.39033056
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38452862
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38349658
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35324744
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34995763
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33835963
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33265459
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30766734
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29582326
69ATF3_27146783_Chip-Seq_COLON_Human1.27898019
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27213395
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27137554
72* FOXA1_25552417_ChIP-Seq_VCAP_Human1.27004661
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26205441
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25828272
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25189569
76KDM2B_26808549_Chip-Seq_DND41_Human1.22882968
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22241675
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.18466802
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18368008
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17788133
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17026921
82EGR1_19032775_ChIP-ChIP_M12_Human1.16739229
83* KDM2B_26808549_Chip-Seq_K562_Human1.16589659
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13821916
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12490016
86STAT1_20625510_ChIP-Seq_HELA_Human1.11538855
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10253568
88CLOCK_20551151_ChIP-Seq_293T_Human1.10081699
89* LXR_22292898_ChIP-Seq_THP-1_Human1.09769600
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09760614
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09561617
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07400178
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06659149
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05498773
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05276658
96RARB_24833708_ChIP-Seq_LIVER_Mouse1.05156309
97TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.03989484
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03980981
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03850882
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02569116
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02282495
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01528622
103* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01260338
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98691657
105CTCF_27219007_Chip-Seq_Bcells_Human0.97568994
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97405021
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96152384
108* CHD1_26751641_Chip-Seq_LNCaP_Human0.96060833
109TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95946819
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95530588
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95526545
112* AHR_22903824_ChIP-Seq_MCF-7_Human0.95017750
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95003738
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94436135
115XRN2_22483619_ChIP-Seq_HELA_Human0.93935785
116DROSHA_22980978_ChIP-Seq_HELA_Human0.92174215
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91844106
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91134734
119TP63_22573176_ChIP-Seq_HFKS_Human0.91002155
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90620705
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89823473
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89823473
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89208553
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86921649
125HNF4A_19822575_ChIP-Seq_HepG2_Human0.86822107
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86662540
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86397440
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86373438
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.85555857
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.82718925
131ELF5_23300383_ChIP-Seq_T47D_Human0.81906273
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80434656
133P68_20966046_ChIP-Seq_HELA_Human0.79361417
134ERG_20517297_ChIP-Seq_VCAP_Human0.79261725
135* ARNT_22903824_ChIP-Seq_MCF-7_Human0.79139038
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.78202609
137* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76624870
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76589277
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76234221
140BCOR_27268052_Chip-Seq_Bcells_Human0.76192992
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75810857
142* GATA2_19941826_ChIP-Seq_K562_Human0.75304646
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74451119
144RXR_22108803_ChIP-Seq_LS180_Human0.73967640
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73831156
146ZNF274_21170338_ChIP-Seq_K562_Hela0.73519050
147SMC4_20622854_ChIP-Seq_HELA_Human0.73396323
148* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72858307
149* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72585740
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72099216
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72078722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption7.38780382
2MP0010234_abnormal_vibrissa_follicle4.85253506
3MP0003868_abnormal_feces_composition4.59482658
4MP0005365_abnormal_bile_salt4.21398275
5MP0005083_abnormal_biliary_tract4.08738042
6MP0004782_abnormal_surfactant_physiolog3.97894351
7MP0004264_abnormal_extraembryonic_tissu3.73605295
8MP0001664_abnormal_digestion3.67079685
9MP0005220_abnormal_exocrine_pancreas3.45190648
10MP0005085_abnormal_gallbladder_physiolo3.00282247
11MP0003866_abnormal_defecation2.96253860
12MP0000537_abnormal_urethra_morphology2.87921697
13MP0005360_urolithiasis2.78558282
14MP0003705_abnormal_hypodermis_morpholog2.69677778
15MP0000462_abnormal_digestive_system2.38027697
16MP0008004_abnormal_stomach_pH2.37532852
17MP0005076_abnormal_cell_differentiation2.36669820
18* MP0001663_abnormal_digestive_system2.35082493
19* MP0010155_abnormal_intestine_physiology2.33477138
20MP0000383_abnormal_hair_follicle2.31455322
21MP0002139_abnormal_hepatobiliary_system2.26623143
22* MP0005381_digestive/alimentary_phenotyp2.20297678
23MP0005084_abnormal_gallbladder_morpholo2.19397373
24MP0004381_abnormal_hair_follicle2.19259673
25MP0002736_abnormal_nociception_after2.15876479
26MP0004043_abnormal_pH_regulation2.06127277
27MP0000627_abnormal_mammary_gland2.05275648
28* MP0000490_abnormal_crypts_of2.03915284
29MP0001727_abnormal_embryo_implantation2.03411239
30MP0005310_abnormal_salivary_gland2.00476076
31* MP0001873_stomach_inflammation1.79784182
32MP0004233_abnormal_muscle_weight1.76891929
33MP0005646_abnormal_pituitary_gland1.75644869
34* MP0000477_abnormal_intestine_morphology1.72463724
35MP0001881_abnormal_mammary_gland1.65097702
36MP0000678_abnormal_parathyroid_gland1.64521683
37MP0000427_abnormal_hair_cycle1.62155006
38MP0003252_abnormal_bile_duct1.60232965
39MP0000613_abnormal_salivary_gland1.59454122
40MP0005451_abnormal_body_composition1.58563957
41MP0006054_spinal_hemorrhage1.57330953
42MP0001919_abnormal_reproductive_system1.56760021
43MP0003300_gastrointestinal_ulcer1.56369904
44MP0009672_abnormal_birth_weight1.56334978
45MP0001765_abnormal_ion_homeostasis1.55168789
46MP0003183_abnormal_peptide_metabolism1.52760715
47MP0002909_abnormal_adrenal_gland1.50718253
48MP0008875_abnormal_xenobiotic_pharmacok1.49087790
49* MP0000470_abnormal_stomach_morphology1.45878005
50MP0010352_gastrointestinal_tract_polyps1.45517163
51MP0003123_paternal_imprinting1.40258085
52MP0010386_abnormal_urinary_bladder1.36259118
53MP0002822_catalepsy1.35482289
54MP0002160_abnormal_reproductive_system1.35392570
55MP0000377_abnormal_hair_follicle1.33628810
56MP0000579_abnormal_nail_morphology1.30647345
57MP0003942_abnormal_urinary_system1.30615012
58MP0002796_impaired_skin_barrier1.28344430
59MP0009780_abnormal_chondrocyte_physiolo1.28255885
60MP0009643_abnormal_urine_homeostasis1.28241622
61MP0000538_abnormal_urinary_bladder1.26972381
62MP0002249_abnormal_larynx_morphology1.26397234
63MP0005248_abnormal_Harderian_gland1.25178637
64MP0003936_abnormal_reproductive_system1.24863076
65MP0005448_abnormal_energy_balance1.22683540
66MP0008260_abnormal_autophagy1.19422462
67MP0003878_abnormal_ear_physiology1.17472951
68MP0005377_hearing/vestibular/ear_phenot1.17472951
69MP0005165_increased_susceptibility_to1.15752319
70MP0002693_abnormal_pancreas_physiology1.15412204
71MP0010678_abnormal_skin_adnexa1.15359021
72MP0000465_gastrointestinal_hemorrhage1.14113240
73MP0005409_darkened_coat_color1.13971931
74MP0008995_early_reproductive_senescence1.12268042
75MP0002166_altered_tumor_susceptibility1.08763995
76MP0005332_abnormal_amino_acid1.08346100
77MP0010771_integument_phenotype1.07840826
78MP0003566_abnormal_cell_adhesion1.07820195
79MP0005636_abnormal_mineral_homeostasis1.07385522
80MP0001968_abnormal_touch/_nociception1.05542447
81MP0010329_abnormal_lipoprotein_level1.02504225
82MP0005666_abnormal_adipose_tissue1.01594786
83MP0001346_abnormal_lacrimal_gland1.00675989
84MP0002118_abnormal_lipid_homeostasis0.99197518
85MP0003638_abnormal_response/metabolism_0.96015485
86MP0003959_abnormal_lean_body0.95695492
87MP0009840_abnormal_foam_cell0.93725627
88MP0009384_cardiac_valve_regurgitation0.93044456
89MP0002653_abnormal_ependyma_morphology0.92181919
90MP0002108_abnormal_muscle_morphology0.89763458
91MP0001944_abnormal_pancreas_morphology0.89461063
92MP0005166_decreased_susceptibility_to0.88822859
93MP0000467_abnormal_esophagus_morphology0.86368396
94MP0008961_abnormal_basal_metabolism0.85391237
95MP0004185_abnormal_adipocyte_glucose0.85381454
96MP0002098_abnormal_vibrissa_morphology0.83745963
97MP0001756_abnormal_urination0.83366722
98MP0004019_abnormal_vitamin_homeostasis0.78359189
99MP0005075_abnormal_melanosome_morpholog0.76761237
100MP0003806_abnormal_nucleotide_metabolis0.73589442
101MP0002970_abnormal_white_adipose0.73028831
102MP0005375_adipose_tissue_phenotype0.72401475
103MP0000516_abnormal_urinary_system0.71927593
104MP0005367_renal/urinary_system_phenotyp0.71927593
105MP0009931_abnormal_skin_appearance0.71700060
106MP0005058_abnormal_lysosome_morphology0.71660095
107MP0003315_abnormal_perineum_morphology0.70179607
108MP0003693_abnormal_embryo_hatching0.68616643
109MP0001849_ear_inflammation0.67947102
110MP0005647_abnormal_sex_gland0.67759685
111MP0005319_abnormal_enzyme/_coenzyme0.67676783
112MP0005645_abnormal_hypothalamus_physiol0.67618176
113MP0009703_decreased_birth_body0.67179096
114MP0002184_abnormal_innervation0.66756046
115MP0002088_abnormal_embryonic_growth/wei0.66587686
116MP0001340_abnormal_eyelid_morphology0.65467024
117MP0003283_abnormal_digestive_organ0.64402271
118MP0002006_tumorigenesis0.63739836
119MP0002089_abnormal_postnatal_growth/wei0.63571444
120MP0005670_abnormal_white_adipose0.63258350
121MP0008872_abnormal_physiological_respon0.62965577
122MP0009764_decreased_sensitivity_to0.61348991
123MP0002060_abnormal_skin_morphology0.60377376
124MP0003984_embryonic_growth_retardation0.59245818
125MP0002132_abnormal_respiratory_system0.59080331
126MP0003191_abnormal_cellular_cholesterol0.58818705
127MP0010630_abnormal_cardiac_muscle0.58310622
128MP0003941_abnormal_skin_development0.57603550
129MP0001672_abnormal_embryogenesis/_devel0.57556644
130MP0005380_embryogenesis_phenotype0.57556644
131* MP0001845_abnormal_inflammatory_respons0.57417672
132MP0003453_abnormal_keratinocyte_physiol0.56993024
133MP0004947_skin_inflammation0.56388549
134MP0003115_abnormal_respiratory_system0.55933522
135MP0005187_abnormal_penis_morphology0.55657178
136MP0009765_abnormal_xenobiotic_induced0.55559764
137MP0002009_preneoplasia0.54599781
138MP0001216_abnormal_epidermal_layer0.54441627
139MP0000566_synostosis0.54195305
140MP0004885_abnormal_endolymph0.54059941
141MP0005501_abnormal_skin_physiology0.52924267
142MP0002136_abnormal_kidney_physiology0.52049781
143MP0003953_abnormal_hormone_level0.51473989
144MP0004858_abnormal_nervous_system0.51419445
145MP0002896_abnormal_bone_mineralization0.50739725
146MP0000609_abnormal_liver_physiology0.50050207
147MP0005334_abnormal_fat_pad0.49416551
148MP0005408_hypopigmentation0.47573043
149MP0000534_abnormal_ureter_morphology0.47288353
150MP0000762_abnormal_tongue_morphology0.47132144

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)5.85878680
2Right ventricular cardiomyopathy (HP:0011663)5.65800809
3Asymmetry of the thorax (HP:0001555)5.15816112
4Fat malabsorption (HP:0002630)5.13867640
5J-shaped sella turcica (HP:0002680)5.04873478
6Steatorrhea (HP:0002570)4.98554808
7Ileus (HP:0002595)4.67179925
8Sparse lateral eyebrow (HP:0005338)4.51189155
9Testicular atrophy (HP:0000029)4.33102942
10Exocrine pancreatic insufficiency (HP:0001738)4.28027026
11Thin bony cortex (HP:0002753)4.19980595
12Abdominal distention (HP:0003270)4.14998731
13Broad face (HP:0000283)4.13412239
14Concave nail (HP:0001598)4.07696088
15Abnormality of the distal phalanges of the toes (HP:0010182)3.90856511
16Spinal cord compression (HP:0002176)3.67806319
17Malnutrition (HP:0004395)3.61791904
18Testicular neoplasm (HP:0010788)3.56065457
19Micronodular cirrhosis (HP:0001413)3.52241189
20Rectal prolapse (HP:0002035)3.49510596
21Germ cell neoplasia (HP:0100728)3.47071211
22Abnormal tarsal ossification (HP:0008369)3.42112739
23Pustule (HP:0200039)3.37833990
24Flat acetabular roof (HP:0003180)3.37546444
25Abnormal foot bone ossification (HP:0010675)3.31282218
26Myopathic facies (HP:0002058)3.27762507
27Congenital glaucoma (HP:0001087)3.26819811
28Vacuolated lymphocytes (HP:0001922)3.24459774
29Amelogenesis imperfecta (HP:0000705)3.18553876
30Pancreatitis (HP:0001733)3.10277727
31Microglossia (HP:0000171)3.09764146
32Short chin (HP:0000331)3.08011299
33Absent frontal sinuses (HP:0002688)3.07305098
34Abnormality of the intrinsic pathway (HP:0010989)3.07102563
35Hyperactive renin-angiotensin system (HP:0000841)3.06952733
36Macroorchidism (HP:0000053)3.06667463
37Deformed sella turcica (HP:0002681)3.01027444
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.97817417
39Mildly elevated creatine phosphokinase (HP:0008180)2.97354891
40Cervical subluxation (HP:0003308)2.96273521
41Progressive sensorineural hearing impairment (HP:0000408)2.93481610
42Lymphangioma (HP:0100764)2.92022681
43Short nail (HP:0001799)2.87391269
44Syncope (HP:0001279)2.85306021
45Hypoparathyroidism (HP:0000829)2.83481987
46Hypoplasia of the pons (HP:0012110)2.82514526
47Congenital sensorineural hearing impairment (HP:0008527)2.75597242
48Abnormality of the phalanges of the hallux (HP:0010057)2.73371182
49Abnormality of subcutaneous fat tissue (HP:0001001)2.71769712
50Conjugated hyperbilirubinemia (HP:0002908)2.71762466
51Hyperacusis (HP:0010780)2.71518615
52Prolonged QT interval (HP:0001657)2.71417399
53Curly hair (HP:0002212)2.69601819
54Distal lower limb muscle weakness (HP:0009053)2.67557798
55Enlarged penis (HP:0000040)2.64881051
56Woolly hair (HP:0002224)2.64695460
57Termporal pattern (HP:0011008)2.63813929
58Insidious onset (HP:0003587)2.63813929
59Abnormality of the pons (HP:0007361)2.63469659
60Lip pit (HP:0100267)2.63197952
61Abnormality of the 1st metacarpal (HP:0010009)2.56163677
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.55406127
63Hyperglycinuria (HP:0003108)2.54253546
64Chronic diarrhea (HP:0002028)2.53299714
65Abnormality of chloride homeostasis (HP:0011422)2.51168992
66Barrel-shaped chest (HP:0001552)2.49652745
67Abnormality of carpal bone ossification (HP:0006257)2.48706117
68Breast carcinoma (HP:0003002)2.48124018
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.47997612
70Abnormality of the gastric mucosa (HP:0004295)2.46797613
71Long toe (HP:0010511)2.46132670
72Abnormality of the 2nd finger (HP:0004100)2.45686862
73Progressive hearing impairment (HP:0001730)2.42930688
74Decreased subcutaneous fat (HP:0001002)2.40730221
75Gout (HP:0001997)2.38533292
76Ventricular fibrillation (HP:0001663)2.37337180
77Reduced antithrombin III activity (HP:0001976)2.36560323
78Gastrointestinal dysmotility (HP:0002579)2.35835635
79Metabolic alkalosis (HP:0200114)2.35529037
80Atrophic scars (HP:0001075)2.34452632
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.33933936
82Pili torti (HP:0003777)2.33544791
83Abnormality of vitamin B metabolism (HP:0004340)2.32929889
84Aortic aneurysm (HP:0004942)2.32514550
85Symphalangism affecting the phalanges of the hand (HP:0009773)2.31665165
86Villous atrophy (HP:0011473)2.30728876
87Abnormality of small intestinal villus morphology (HP:0011472)2.30728876
88Hyperparathyroidism (HP:0000843)2.28693002
89Palpitations (HP:0001962)2.28364187
90Hypoplasia of the uterus (HP:0000013)2.28189263
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25042678
92Flattened epiphyses (HP:0003071)2.24544756
93Bundle branch block (HP:0011710)2.24302294
94Exostoses (HP:0100777)2.24272145
95Esophageal varix (HP:0002040)2.23448944
96Maternal diabetes (HP:0009800)2.22448693
97Milia (HP:0001056)2.22303202
98Interstitial pulmonary disease (HP:0006530)2.22130198
99Ankyloglossia (HP:0010296)2.21018017
100Dehydration (HP:0001944)2.17967321
101Abnormality of cochlea (HP:0000375)2.15436707
102Onycholysis (HP:0001806)2.13060039
103Severe short stature (HP:0003510)2.12994652
104Deep venous thrombosis (HP:0002625)2.10792258
105Short 1st metacarpal (HP:0010034)2.10192371
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10192371
107Type I diabetes mellitus (HP:0100651)2.09425763
108Buphthalmos (HP:0000557)2.09259337
109Abnormality of the sella turcica (HP:0002679)2.08342273
110Abnormal ossification of hand bones (HP:0005921)2.07381978
111Biliary tract neoplasm (HP:0100574)2.06184702
112Abnormal protein glycosylation (HP:0012346)2.05786043
113Abnormal glycosylation (HP:0012345)2.05786043
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05786043
115Abnormal protein N-linked glycosylation (HP:0012347)2.05786043
116Abnormality of the umbilical cord (HP:0010881)2.05518146
117Premature skin wrinkling (HP:0100678)2.04920438
118Patellar dislocation (HP:0002999)2.04539762
119Dysostosis multiplex (HP:0000943)2.03587548
120Growth hormone excess (HP:0000845)2.02723616
121Hydroxyprolinuria (HP:0003080)2.02491728
122Abnormality of proline metabolism (HP:0010907)2.02491728
123Abnormality of the frontal sinuses (HP:0002687)2.01910375
124Abnormal biliary tract morphology (HP:0012440)2.00895459
125Widely patent fontanelles and sutures (HP:0004492)2.00689169
126Fatigue (HP:0012378)2.00549684
127Microretrognathia (HP:0000308)2.00317700
128Obstructive sleep apnea (HP:0002870)1.99803081
129Partial duplication of thumb phalanx (HP:0009944)1.98503777
130Abnormality of vitamin metabolism (HP:0100508)1.98062743
131Short hallux (HP:0010109)1.98040837
132Bronchomalacia (HP:0002780)1.96699017
133Broad nasal tip (HP:0000455)1.95975020
134Alopecia of scalp (HP:0002293)1.95680180
135Short phalanx of the thumb (HP:0009660)1.94524930
136Abnormal hair laboratory examination (HP:0003328)1.94450678
137Abnormal hand bone ossification (HP:0010660)1.94370531
138Hyperphosphatemia (HP:0002905)1.93602469
139Bulbar palsy (HP:0001283)1.93536091
140Abnormal pancreas size (HP:0012094)1.93304093
141Potter facies (HP:0002009)1.92888669
142Facial shape deformation (HP:0011334)1.92888669
143Advanced eruption of teeth (HP:0006288)1.92642662
144Hypoplastic nipples (HP:0002557)1.91352336
145Stridor (HP:0010307)1.90924059
146Abnormality of the middle phalanges of the toes (HP:0010183)1.90776101
147Abnormality of glycine metabolism (HP:0010895)1.89917987
148Abnormality of serine family amino acid metabolism (HP:0010894)1.89917987
149Male infertility (HP:0003251)1.88067127
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86981544
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.86767436
152Cheilitis (HP:0100825)1.86412701
153Diaphragmatic weakness (HP:0009113)1.84725545
154Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84660422
155Protuberant abdomen (HP:0001538)1.83191489
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.81906960
157Ketoacidosis (HP:0001993)1.80312289
158Abnormality of the proximal phalanges of the hand (HP:0009834)1.80285222
159Ureteral stenosis (HP:0000071)1.80283613
160Vascular calcification (HP:0004934)1.80174609
161Hypopigmentation of the fundus (HP:0007894)1.80078304
162Congenital ichthyosiform erythroderma (HP:0007431)1.79678431
163Abnormal vertebral ossification (HP:0100569)1.78958121
164Aplasia/hypoplasia of the femur (HP:0005613)1.77093930
165Fasciculations (HP:0002380)1.76788321
166Axonal loss (HP:0003447)1.74108843
167Abnormality of the fetal cardiovascular system (HP:0010948)1.73685049
168Abnormal umbilical cord blood vessels (HP:0011403)1.73685049
169Single umbilical artery (HP:0001195)1.73685049
170High pitched voice (HP:0001620)1.72501711
171Back pain (HP:0003418)1.72303424
172Renal dysplasia (HP:0000110)1.71685695
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70745625
174Visceral angiomatosis (HP:0100761)1.69487808
175Broad metatarsal (HP:0001783)1.69212783
176Achilles tendon contracture (HP:0001771)1.67418838
177Tracheal stenosis (HP:0002777)1.65967058
178Morphological abnormality of the middle ear (HP:0008609)1.65369275
179Preauricular skin tag (HP:0000384)1.65134602
180Osteolytic defects of the hand bones (HP:0009699)1.60242724
181Osteolytic defects of the phalanges of the hand (HP:0009771)1.60242724
182Abnormality of the Achilles tendon (HP:0005109)1.59594578
183Partial duplication of the phalanx of hand (HP:0009999)1.59109251
184Abnormality of the parathyroid morphology (HP:0011766)1.58675039
185Missing ribs (HP:0000921)1.56712551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.63630871
2ERN14.46733012
3BCKDK4.36670880
4MST43.83086483
5LMTK23.46194837
6NME13.41599670
7MAP2K23.23070520
8AKT33.13996612
9PIK3CA2.85637740
10CAMK1D2.60282864
11MST1R2.52249322
12EEF2K2.39708529
13RPS6KB22.33439658
14TAOK32.26061325
15SMG12.25339227
16MYLK2.22668558
17STK392.12908246
18LATS12.06203525
19TESK21.99307003
20NME21.95417684
21CAMK1G1.88914957
22FGFR41.86756497
23TESK11.83410621
24PTK61.75697089
25MAPKAPK31.72958501
26MAP3K21.62337745
27MAP3K121.59576572
28PAK41.55611101
29MUSK1.48559277
30TNK21.46256662
31PIK3CG1.41173284
32PRKG21.39470757
33TRIB31.30317549
34PRKCI1.24548374
35MAP2K11.24538245
36PKN21.23086669
37FER1.21837878
38PRKD21.18238233
39PAK21.15403504
40EPHA21.14500336
41CDK71.12551284
42NUAK11.08020716
43OXSR11.07198833
44NEK61.06750749
45CHUK1.06253017
46SIK31.03738142
47PDK21.03610584
48EIF2AK10.99776950
49EPHB20.98016860
50MET0.97515257
51DDR20.90794312
52SIK10.86782158
53TAOK10.84912767
54KSR20.82925332
55DMPK0.82404357
56IRAK20.81689310
57VRK20.81463007
58RPS6KC10.81338327
59RPS6KL10.81338327
60MARK20.81278351
61LIMK10.79790658
62LRRK20.77870479
63PRKD30.77305514
64SCYL20.77219551
65TTN0.76677828
66CAMK2D0.75837762
67RIPK10.75633936
68WNK40.74830883
69IKBKE0.72541030
70RET0.71916344
71PTK20.67294183
72CAMK2B0.66279523
73ICK0.65545873
74MAP3K70.65500394
75RPS6KA60.64844715
76CDK120.63666797
77GRK60.62788674
78MAPK150.61418396
79MAP2K60.59314438
80INSRR0.58759155
81EIF2AK30.58597212
82CAMK2G0.57809179
83PRKD10.57578071
84MAPKAPK20.56069948
85TBK10.54082658
86STK100.53541634
87ERBB20.52871795
88RPS6KA20.52504324
89ROCK10.50310533
90MAP3K80.50059164
91BMX0.49040386
92PHKG20.48686985
93PHKG10.48686985
94DYRK1B0.48512840
95GRK10.48109812
96STK240.46659775
97MATK0.43670620
98AURKA0.42443572
99HIPK20.42251212
100MAP3K90.40974252
101PAK10.40573584
102DAPK10.40273093
103CDK190.39068840
104PDK40.37729666
105PDK30.37729666
106FGFR20.35917877
107PDPK10.34496608
108RPS6KA40.34168846
109MAP3K110.34147880
110PDGFRB0.33008888
111PRKAA20.32142951
112PRKAA10.31321016
113PAK30.29780662
114MAP3K30.29605097
115STK38L0.29487849
116ARAF0.28814077
117MAP3K100.27589996
118PIM20.26683505
119PDGFRA0.26324568
120TRPM70.25932548
121IRAK30.25564342
122MAPK80.25450505
123MAPKAPK50.25281439
124BRAF0.24925930
125EPHB10.24717030
126TRIM280.24539135
127MAP3K10.22355064
128RPS6KB10.22234418
129CDC42BPA0.21682199
130PDK10.21321209
131RPS6KA10.20684767
132AKT20.20131006
133PRKCA0.19953844
134ILK0.19615974
135IRAK40.18804803
136PRKCZ0.18545200
137ERBB40.18536167
138MTOR0.17277576
139DYRK1A0.17213408
140ROCK20.17116800
141CAMKK10.16731844
142TAOK20.16324128
143CDK180.10883806
144MAPK40.10173669

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.24330225
2Pancreatic secretion_Homo sapiens_hsa049724.76232822
3Sulfur metabolism_Homo sapiens_hsa009204.39056812
4Fatty acid biosynthesis_Homo sapiens_hsa000613.73207555
5Protein digestion and absorption_Homo sapiens_hsa049743.46537777
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.75421760
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52273007
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45525424
9Renin-angiotensin system_Homo sapiens_hsa046142.41880476
10Protein export_Homo sapiens_hsa030602.23565402
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.22083179
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13707784
13Mineral absorption_Homo sapiens_hsa049782.11233885
14Phenylalanine metabolism_Homo sapiens_hsa003602.09128000
15Estrogen signaling pathway_Homo sapiens_hsa049151.96700837
16Linoleic acid metabolism_Homo sapiens_hsa005911.93869038
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93445362
18Acute myeloid leukemia_Homo sapiens_hsa052211.89034045
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.88099052
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85800218
21Glycerolipid metabolism_Homo sapiens_hsa005611.82392038
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80629258
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.79321553
24Notch signaling pathway_Homo sapiens_hsa043301.76757003
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.72900611
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.70668591
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68528979
28Fructose and mannose metabolism_Homo sapiens_hsa000511.65833857
29Folate biosynthesis_Homo sapiens_hsa007901.65672009
30mTOR signaling pathway_Homo sapiens_hsa041501.65439611
31Insulin signaling pathway_Homo sapiens_hsa049101.58491422
32Vibrio cholerae infection_Homo sapiens_hsa051101.56550561
33VEGF signaling pathway_Homo sapiens_hsa043701.53572451
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52824187
35Non-small cell lung cancer_Homo sapiens_hsa052231.51722855
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50521121
37ErbB signaling pathway_Homo sapiens_hsa040121.42382544
38Vitamin digestion and absorption_Homo sapiens_hsa049771.40568508
39N-Glycan biosynthesis_Homo sapiens_hsa005101.40435290
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37172046
41Bile secretion_Homo sapiens_hsa049761.32471736
42Chronic myeloid leukemia_Homo sapiens_hsa052201.31571858
43Prolactin signaling pathway_Homo sapiens_hsa049171.30016616
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29700144
45Renal cell carcinoma_Homo sapiens_hsa052111.27868806
46Fatty acid metabolism_Homo sapiens_hsa012121.27493689
47Glucagon signaling pathway_Homo sapiens_hsa049221.26901184
48Steroid biosynthesis_Homo sapiens_hsa001001.24280324
49Choline metabolism in cancer_Homo sapiens_hsa052311.23684829
50Histidine metabolism_Homo sapiens_hsa003401.21624867
51Propanoate metabolism_Homo sapiens_hsa006401.20833475
52Arginine and proline metabolism_Homo sapiens_hsa003301.14202122
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13217338
54Tight junction_Homo sapiens_hsa045301.12884260
55Tyrosine metabolism_Homo sapiens_hsa003501.12268009
56Galactose metabolism_Homo sapiens_hsa000521.07549629
57Arachidonic acid metabolism_Homo sapiens_hsa005901.04163085
58Starch and sucrose metabolism_Homo sapiens_hsa005001.03250500
59Glioma_Homo sapiens_hsa052140.96719711
60Pancreatic cancer_Homo sapiens_hsa052120.93397793
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.91068476
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88889405
63Proteoglycans in cancer_Homo sapiens_hsa052050.88737783
64Other glycan degradation_Homo sapiens_hsa005110.87890779
65Glutathione metabolism_Homo sapiens_hsa004800.86399192
66Ether lipid metabolism_Homo sapiens_hsa005650.85886631
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.84353580
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84200204
69Lysine degradation_Homo sapiens_hsa003100.83975784
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82369165
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80292423
72Tryptophan metabolism_Homo sapiens_hsa003800.79907811
73Lysosome_Homo sapiens_hsa041420.79080563
74Endocytosis_Homo sapiens_hsa041440.76130641
75Fatty acid degradation_Homo sapiens_hsa000710.74970110
76Thyroid hormone synthesis_Homo sapiens_hsa049180.74397717
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72104525
78Pyruvate metabolism_Homo sapiens_hsa006200.71690398
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71637941
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71353108
81Gastric acid secretion_Homo sapiens_hsa049710.71229462
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71042785
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69962264
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68519460
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68128346
86beta-Alanine metabolism_Homo sapiens_hsa004100.67803623
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67071718
88Oxidative phosphorylation_Homo sapiens_hsa001900.66669703
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64536096
90Melanoma_Homo sapiens_hsa052180.64361523
91Salivary secretion_Homo sapiens_hsa049700.62909972
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62806444
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62588919
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.62445096
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62363454
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60192610
97PPAR signaling pathway_Homo sapiens_hsa033200.57827145
98Alzheimers disease_Homo sapiens_hsa050100.57215799
99Hepatitis B_Homo sapiens_hsa051610.53378211
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.52704652
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51450786
102HIF-1 signaling pathway_Homo sapiens_hsa040660.50181968
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.48981692
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48113892
105Hepatitis C_Homo sapiens_hsa051600.48097806
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.47792728
107Small cell lung cancer_Homo sapiens_hsa052220.47352461
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.46935738
109Melanogenesis_Homo sapiens_hsa049160.46841242
110Colorectal cancer_Homo sapiens_hsa052100.45295223
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44482532
112Axon guidance_Homo sapiens_hsa043600.43679914
113Chemical carcinogenesis_Homo sapiens_hsa052040.43128915
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42811382
115Butanoate metabolism_Homo sapiens_hsa006500.41680918
116Hippo signaling pathway_Homo sapiens_hsa043900.41363889
117Fatty acid elongation_Homo sapiens_hsa000620.41239346
118Carbon metabolism_Homo sapiens_hsa012000.40572425
119Insulin secretion_Homo sapiens_hsa049110.40371016
120Biosynthesis of amino acids_Homo sapiens_hsa012300.40114864
121Base excision repair_Homo sapiens_hsa034100.39561986
122Adherens junction_Homo sapiens_hsa045200.38325288
123Parkinsons disease_Homo sapiens_hsa050120.38236386
124Endometrial cancer_Homo sapiens_hsa052130.38053182
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37818652
126Thyroid cancer_Homo sapiens_hsa052160.37748341
127Selenocompound metabolism_Homo sapiens_hsa004500.37017220
128Focal adhesion_Homo sapiens_hsa045100.36106619
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35921564
130Metabolic pathways_Homo sapiens_hsa011000.35409407
131Influenza A_Homo sapiens_hsa051640.34592056
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33901009
133Cholinergic synapse_Homo sapiens_hsa047250.33493622
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.32990278
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32964454
136Arginine biosynthesis_Homo sapiens_hsa002200.32670322
137Bladder cancer_Homo sapiens_hsa052190.31829503
138Sphingolipid metabolism_Homo sapiens_hsa006000.31796125
139Renin secretion_Homo sapiens_hsa049240.28690285
140Amoebiasis_Homo sapiens_hsa051460.28097702
141ABC transporters_Homo sapiens_hsa020100.24957248
142Pentose phosphate pathway_Homo sapiens_hsa000300.23542965
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23168695
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.23059826
145Sulfur relay system_Homo sapiens_hsa041220.17755856
146Collecting duct acid secretion_Homo sapiens_hsa049660.16217506
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15183806
148Inositol phosphate metabolism_Homo sapiens_hsa005620.13734048
149Prostate cancer_Homo sapiens_hsa052150.13717114
150Caffeine metabolism_Homo sapiens_hsa002320.13455700
151AMPK signaling pathway_Homo sapiens_hsa041520.12621606
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12338776
153Insulin resistance_Homo sapiens_hsa049310.09463650
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07777832
155Legionellosis_Homo sapiens_hsa051340.07704077

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