SPDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitotic metaphase plate congression (GO:0007080)5.69448776
2* protein localization to kinetochore (GO:0034501)5.67877815
3mitotic chromosome condensation (GO:0007076)5.05049494
4* protein localization to chromosome, centromeric region (GO:0071459)4.99511554
5attachment of spindle microtubules to kinetochore (GO:0008608)4.99240846
6mitotic sister chromatid segregation (GO:0000070)4.95345566
7regulation of spindle organization (GO:0090224)4.93731174
8* metaphase plate congression (GO:0051310)4.88629265
9kinetochore organization (GO:0051383)4.81968582
10DNA replication checkpoint (GO:0000076)4.70000179
11CENP-A containing nucleosome assembly (GO:0034080)4.63205210
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.60439885
13nuclear pore complex assembly (GO:0051292)4.58069133
14nuclear pore organization (GO:0006999)4.56283208
15sister chromatid segregation (GO:0000819)4.55037573
16chromatin remodeling at centromere (GO:0031055)4.54759847
17establishment of integrated proviral latency (GO:0075713)4.46425625
18* establishment of chromosome localization (GO:0051303)4.44356778
19mitotic nuclear envelope disassembly (GO:0007077)4.42764315
20regulation of mitotic spindle organization (GO:0060236)4.32368426
21kinetochore assembly (GO:0051382)4.30989560
22DNA replication-independent nucleosome organization (GO:0034724)4.23326281
23DNA replication-independent nucleosome assembly (GO:0006336)4.23326281
24meiotic chromosome segregation (GO:0045132)4.17512309
25DNA replication initiation (GO:0006270)4.16815597
26positive regulation of chromosome segregation (GO:0051984)4.15200245
27membrane disassembly (GO:0030397)4.12863231
28nuclear envelope disassembly (GO:0051081)4.12863231
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.10241118
30histone exchange (GO:0043486)4.06958924
31DNA replication-dependent nucleosome organization (GO:0034723)3.99049749
32DNA replication-dependent nucleosome assembly (GO:0006335)3.99049749
33DNA strand elongation involved in DNA replication (GO:0006271)3.96873240
34DNA ligation (GO:0006266)3.92385266
35regulation of chromosome segregation (GO:0051983)3.89586428
36* spindle checkpoint (GO:0031577)3.89460075
37* protein localization to chromosome (GO:0034502)3.88862330
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.88162369
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.88162369
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.88162369
41chromosome segregation (GO:0007059)3.83539833
42DNA unwinding involved in DNA replication (GO:0006268)3.77043103
43DNA strand elongation (GO:0022616)3.76554017
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.75968234
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75927941
46negative regulation of chromosome segregation (GO:0051985)3.71276771
47spindle assembly checkpoint (GO:0071173)3.68373199
48telomere maintenance via semi-conservative replication (GO:0032201)3.67453359
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.67219965
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.67008590
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67008590
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67008590
53negative regulation of sister chromatid segregation (GO:0033046)3.67008590
54mitotic recombination (GO:0006312)3.66772100
55mitotic spindle checkpoint (GO:0071174)3.64933013
56telomere maintenance via recombination (GO:0000722)3.63230817
57protein K6-linked ubiquitination (GO:0085020)3.61558470
58mitotic spindle assembly checkpoint (GO:0007094)3.59470689
59ribosome assembly (GO:0042255)3.58150038
60pore complex assembly (GO:0046931)3.55939343
61regulation of mitotic sister chromatid separation (GO:0010965)3.54424539
62regulation of mitotic sister chromatid segregation (GO:0033047)3.54424539
63regulation of sister chromatid segregation (GO:0033045)3.54424539
64mitotic sister chromatid cohesion (GO:0007064)3.54236155
65regulation of sister chromatid cohesion (GO:0007063)3.53620901
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51122177
67regulation of centrosome cycle (GO:0046605)3.50544460
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.50211324
69chromatin assembly or disassembly (GO:0006333)3.47441055
70nucleobase biosynthetic process (GO:0046112)3.45978123
71DNA topological change (GO:0006265)3.43891251
72regulation of DNA endoreduplication (GO:0032875)3.42724889
73purine nucleobase biosynthetic process (GO:0009113)3.40872554
74proteasome assembly (GO:0043248)3.37363710
75centriole replication (GO:0007099)3.37169434
76establishment of viral latency (GO:0019043)3.35570950
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35053740
78chromosome condensation (GO:0030261)3.28212424
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25836869
80regulation of exit from mitosis (GO:0007096)3.25165247
81nuclear envelope organization (GO:0006998)3.24482839
82mitotic spindle organization (GO:0007052)3.23955406
83ATP-dependent chromatin remodeling (GO:0043044)3.20504472
84regulation of centriole replication (GO:0046599)3.16700849
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16530501
86regulation of mitotic spindle checkpoint (GO:1903504)3.16530501
87spindle assembly involved in mitosis (GO:0090307)3.16528769
88ribosome biogenesis (GO:0042254)3.15219134
89telomere maintenance via telomere lengthening (GO:0010833)3.13154814
90regulation of telomere maintenance via telomerase (GO:0032210)3.13080159
91regulation of spindle checkpoint (GO:0090231)3.12439561
92synapsis (GO:0007129)3.12308407
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12243256
94microtubule depolymerization (GO:0007019)3.10768760
95non-recombinational repair (GO:0000726)3.05100192
96double-strand break repair via nonhomologous end joining (GO:0006303)3.05100192
97monoubiquitinated protein deubiquitination (GO:0035520)3.03836613
98* mitotic cell cycle (GO:0000278)3.00384605
99ventricular cardiac muscle cell development (GO:0055015)3.00362952
100IMP biosynthetic process (GO:0006188)3.00283332
101formation of translation preinitiation complex (GO:0001731)2.99619031
102DNA packaging (GO:0006323)2.99560358
103histone-serine phosphorylation (GO:0035404)2.99008099
104folic acid-containing compound biosynthetic process (GO:0009396)2.98995833
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97087297
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.94360291
107mitotic G2/M transition checkpoint (GO:0044818)2.91975893
108regulation of DNA methylation (GO:0044030)2.91880149
109mitotic nuclear division (GO:0007067)2.91688863
110DNA geometric change (GO:0032392)2.91396160
111negative regulation of mitosis (GO:0045839)2.90887955
112DNA duplex unwinding (GO:0032508)2.90051536
113maturation of 5.8S rRNA (GO:0000460)2.87782662
114negative regulation of nuclear division (GO:0051784)2.87482943
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.85554769
116replication fork processing (GO:0031297)2.85016411
117DNA conformation change (GO:0071103)2.84442728
118regulation of histone H3-K9 methylation (GO:0051570)2.84272991
119maturation of SSU-rRNA (GO:0030490)2.83635303
120histone H2A monoubiquitination (GO:0035518)2.83438539
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.80372400
122negative regulation of histone methylation (GO:0031061)2.79779943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.64961752
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.56708095
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.54992039
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.16698347
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.61416485
6AR_21909140_ChIP-Seq_LNCAP_Human2.90320356
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83672556
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71459052
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66030811
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64808700
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52469017
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.48138533
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44126528
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.36032335
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34099129
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.33532589
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32351348
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.29808421
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29744396
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.26394482
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13202056
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12760080
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08897514
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07250717
25XRN2_22483619_ChIP-Seq_HELA_Human2.01755551
26VDR_23849224_ChIP-Seq_CD4+_Human1.99422152
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91429781
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87172802
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81261403
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76775155
31FOXP3_21729870_ChIP-Seq_TREG_Human1.72319957
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70203953
33DCP1A_22483619_ChIP-Seq_HELA_Human1.68295959
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67155694
35ELK1_19687146_ChIP-ChIP_HELA_Human1.63592140
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62621518
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.58870277
38GABP_19822575_ChIP-Seq_HepG2_Human1.58608020
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58500607
40TTF2_22483619_ChIP-Seq_HELA_Human1.58468579
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.52554190
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49191789
43KDM5A_27292631_Chip-Seq_BREAST_Human1.47368163
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46750325
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41547524
46MYC_22102868_ChIP-Seq_BL_Human1.39773329
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37106890
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35692907
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32349648
50CIITA_25753668_ChIP-Seq_RAJI_Human1.32262197
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31926164
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31852235
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29864409
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29116098
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26126445
56EWS_26573619_Chip-Seq_HEK293_Human1.24556748
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24337181
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21962992
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21141365
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20124303
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19452869
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16652220
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13905269
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13575935
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.11613177
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11253056
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.11099542
68TFEB_21752829_ChIP-Seq_HELA_Human1.10091064
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.10032836
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09264635
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08387956
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07675042
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05686197
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04765956
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03841221
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03841221
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03841221
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03293431
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01817303
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99957993
81FUS_26573619_Chip-Seq_HEK293_Human0.99329315
82MYC_18940864_ChIP-ChIP_HL60_Human0.98814841
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.98474645
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.98447946
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98019887
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95646703
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.95556449
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95192800
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95180779
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94264845
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92082604
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88767592
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88357759
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87598906
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87353109
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86845004
97SPI1_23547873_ChIP-Seq_NB4_Human0.86533507
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86200407
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83674399
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83515989
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83387850
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83302784
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82251684
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81872806
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81660015
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78336006
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.78053784
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.77679190
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74212854
110VDR_21846776_ChIP-Seq_THP-1_Human0.72967624
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72965235
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.72470949
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72200518
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71797179
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70846988
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70768579
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.70609476
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70050006
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69744916
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.65426837
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65175880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.99767901
2MP0010094_abnormal_chromosome_stability4.82304455
3MP0003111_abnormal_nucleus_morphology4.80116149
4MP0003077_abnormal_cell_cycle4.30243739
5MP0004957_abnormal_blastocyst_morpholog4.20813202
6MP0008057_abnormal_DNA_replication4.12853618
7MP0008007_abnormal_cellular_replicative2.98456302
8MP0008058_abnormal_DNA_repair2.97424996
9MP0008932_abnormal_embryonic_tissue2.59283575
10MP0010307_abnormal_tumor_latency2.47796254
11MP0001730_embryonic_growth_arrest2.42769858
12MP0000350_abnormal_cell_proliferation2.39073256
13MP0003123_paternal_imprinting2.38577831
14MP0003718_maternal_effect2.37914508
15MP0008877_abnormal_DNA_methylation2.25575564
16MP0002396_abnormal_hematopoietic_system2.14699182
17MP0009697_abnormal_copulation1.96322125
18MP0010352_gastrointestinal_tract_polyps1.94210481
19MP0005380_embryogenesis_phenotype1.92927330
20MP0001672_abnormal_embryogenesis/_devel1.92927330
21MP0008789_abnormal_olfactory_epithelium1.81787408
22MP0001697_abnormal_embryo_size1.77273188
23MP0003984_embryonic_growth_retardation1.67049896
24MP0003786_premature_aging1.66233221
25MP0002085_abnormal_embryonic_tissue1.62987025
26MP0002088_abnormal_embryonic_growth/wei1.62984306
27MP0005076_abnormal_cell_differentiation1.60381949
28MP0002080_prenatal_lethality1.53828081
29MP0002084_abnormal_developmental_patter1.48854782
30MP0000490_abnormal_crypts_of1.48749873
31MP0002086_abnormal_extraembryonic_tissu1.46123866
32MP0000313_abnormal_cell_death1.42349846
33MP0003121_genomic_imprinting1.40777678
34MP0002210_abnormal_sex_determination1.39831797
35MP0002019_abnormal_tumor_incidence1.38932345
36MP0005499_abnormal_olfactory_system1.36391766
37MP0005394_taste/olfaction_phenotype1.36391766
38MP0002234_abnormal_pharynx_morphology1.33983267
39MP0004808_abnormal_hematopoietic_stem1.33966746
40MP0002697_abnormal_eye_size1.31218599
41MP0003950_abnormal_plasma_membrane1.27615348
42MP0004197_abnormal_fetal_growth/weight/1.26239200
43MP0006292_abnormal_olfactory_placode1.26006908
44MP0001929_abnormal_gametogenesis1.23417672
45MP0001119_abnormal_female_reproductive1.22511307
46MP0002233_abnormal_nose_morphology1.21915720
47MP0005623_abnormal_meninges_morphology1.19375856
48MP0001145_abnormal_male_reproductive1.15599133
49MP0000653_abnormal_sex_gland1.14534150
50MP0003705_abnormal_hypodermis_morpholog1.14412205
51MP0009333_abnormal_splenocyte_physiolog1.13272993
52MP0003567_abnormal_fetal_cardiomyocyte1.12853955
53MP0000762_abnormal_tongue_morphology1.10595227
54MP0005397_hematopoietic_system_phenotyp1.10001146
55MP0001545_abnormal_hematopoietic_system1.10001146
56MP0003937_abnormal_limbs/digits/tail_de1.08012856
57MP0000049_abnormal_middle_ear1.07920325
58MP0003315_abnormal_perineum_morphology1.06817942
59MP0003890_abnormal_embryonic-extraembry1.06273365
60MP0010030_abnormal_orbit_morphology1.03217149
61MP0000537_abnormal_urethra_morphology1.02842885
62MP0002938_white_spotting1.02143859
63MP0009250_abnormal_appendicular_skeleto0.99851455
64MP0005621_abnormal_cell_physiology0.97138846
65MP0000703_abnormal_thymus_morphology0.95640981
66MP0001293_anophthalmia0.95408511
67MP0002398_abnormal_bone_marrow0.94064772
68MP0001915_intracranial_hemorrhage0.92772903
69MP0002653_abnormal_ependyma_morphology0.89998734
70MP0003699_abnormal_female_reproductive0.89567535
71MP0006072_abnormal_retinal_apoptosis0.89397279
72MP0002722_abnormal_immune_system0.88886293
73MP0000689_abnormal_spleen_morphology0.88084494
74MP0005384_cellular_phenotype0.87782857
75MP0009053_abnormal_anal_canal0.86978489
76MP0001299_abnormal_eye_distance/0.86085019
77MP0003566_abnormal_cell_adhesion0.83014342
78MP0005023_abnormal_wound_healing0.82939982
79MP0009672_abnormal_birth_weight0.81837708
80MP0003763_abnormal_thymus_physiology0.81238071
81MP0005395_other_phenotype0.81063859
82MP0003861_abnormal_nervous_system0.80698034
83MP0003136_yellow_coat_color0.80277179
84MP0003448_altered_tumor_morphology0.79043736
85MP0000858_altered_metastatic_potential0.77653522
86MP0003385_abnormal_body_wall0.74621249
87MP0001849_ear_inflammation0.74201722
88MP0002877_abnormal_melanocyte_morpholog0.73790908
89MP0002102_abnormal_ear_morphology0.73157274
90MP0002160_abnormal_reproductive_system0.72101446
91MP0001529_abnormal_vocalization0.71942972
92MP0005501_abnormal_skin_physiology0.71017909
93MP0005389_reproductive_system_phenotype0.70337225
94MP0000428_abnormal_craniofacial_morphol0.69840192
95MP0002111_abnormal_tail_morphology0.69501603
96MP0000569_abnormal_digit_pigmentation0.69119662
97MP0002429_abnormal_blood_cell0.69085758
98MP0003698_abnormal_male_reproductive0.68877892
99MP0005187_abnormal_penis_morphology0.68627376
100MP0000647_abnormal_sebaceous_gland0.67782715
101MP0005197_abnormal_uvea_morphology0.67457321
102MP0006035_abnormal_mitochondrial_morpho0.67207184
103MP0009703_decreased_birth_body0.67113678
104MP0010368_abnormal_lymphatic_system0.66879931
105MP0003806_abnormal_nucleotide_metabolis0.66755113
106MP0000432_abnormal_head_morphology0.66706285
107MP0003186_abnormal_redox_activity0.66527017
108MP0003119_abnormal_digestive_system0.65457291
109MP0003221_abnormal_cardiomyocyte_apopto0.65250381
110MP0002177_abnormal_outer_ear0.65190348
111MP0001346_abnormal_lacrimal_gland0.64750444
112MP0005391_vision/eye_phenotype0.64498651
113MP0000627_abnormal_mammary_gland0.64328502
114MP0004264_abnormal_extraembryonic_tissu0.64318145
115MP0004272_abnormal_basement_membrane0.64181632
116MP0002114_abnormal_axial_skeleton0.63198840
117MP0009379_abnormal_foot_pigmentation0.62750030
118MP0002161_abnormal_fertility/fecundity0.62466480
119MP0001286_abnormal_eye_development0.60345640
120MP0005408_hypopigmentation0.60270384
121MP0000716_abnormal_immune_system0.60230353
122MP0003755_abnormal_palate_morphology0.60114686
123MP0009278_abnormal_bone_marrow0.59958158
124MP0000733_abnormal_muscle_development0.58515664
125MP0002092_abnormal_eye_morphology0.57822026
126MP0000358_abnormal_cell_content/0.57661503
127MP0005451_abnormal_body_composition0.55962003
128MP0003941_abnormal_skin_development0.54611266
129MP0001800_abnormal_humoral_immune0.54239716
130MP0003935_abnormal_craniofacial_develop0.53624128
131MP0000477_abnormal_intestine_morphology0.52998449
132MP0002006_tumorigenesis0.52471462
133MP0001919_abnormal_reproductive_system0.50747602
134MP0002925_abnormal_cardiovascular_devel0.50620681
135MP0003936_abnormal_reproductive_system0.50582508
136MP0002452_abnormal_antigen_presenting0.50051427

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.40433556
2Chromsome breakage (HP:0040012)5.14538338
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.94622048
4Breast hypoplasia (HP:0003187)4.49886332
5Patellar aplasia (HP:0006443)3.92791417
6Abnormality of chromosome stability (HP:0003220)3.83392024
7Impulsivity (HP:0100710)3.73975872
8Aplasia/Hypoplasia of the patella (HP:0006498)3.72626317
9Meckel diverticulum (HP:0002245)3.66678591
10Abnormality of the preputium (HP:0100587)3.54256847
11Abnormality of the labia minora (HP:0012880)3.48556422
12Abnormality of the ileum (HP:0001549)3.45002890
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.41946383
14Carpal bone hypoplasia (HP:0001498)3.34206427
15Facial hemangioma (HP:0000329)3.23484198
16Duodenal stenosis (HP:0100867)3.15317555
17Small intestinal stenosis (HP:0012848)3.15317555
18Absent radius (HP:0003974)3.02136009
19Ectopic kidney (HP:0000086)2.98255832
20Selective tooth agenesis (HP:0001592)2.96831125
21Myelodysplasia (HP:0002863)2.93870851
22Aplasia involving forearm bones (HP:0009822)2.80872239
23Absent forearm bone (HP:0003953)2.80872239
24Reticulocytopenia (HP:0001896)2.80484772
25Medulloblastoma (HP:0002885)2.72233809
26Oral leukoplakia (HP:0002745)2.65230878
27Sloping forehead (HP:0000340)2.64620290
28Rhabdomyosarcoma (HP:0002859)2.58723141
29Ependymoma (HP:0002888)2.56395941
30Abnormal lung lobation (HP:0002101)2.53736363
31Abnormality of the duodenum (HP:0002246)2.50916364
32Bone marrow hypocellularity (HP:0005528)2.50153425
33Nephroblastoma (Wilms tumor) (HP:0002667)2.49321233
34Abnormality of the anterior horn cell (HP:0006802)2.48855163
35Degeneration of anterior horn cells (HP:0002398)2.48855163
36Agnosia (HP:0010524)2.48106013
37Abnormality of the septum pellucidum (HP:0007375)2.47740525
38Septo-optic dysplasia (HP:0100842)2.45476306
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.45474460
40Absent thumb (HP:0009777)2.45203256
41Absent septum pellucidum (HP:0001331)2.45155978
42Increased nuchal translucency (HP:0010880)2.43722461
43Short thumb (HP:0009778)2.42727467
44Colon cancer (HP:0003003)2.41958668
45Premature ovarian failure (HP:0008209)2.40153455
46Cafe-au-lait spot (HP:0000957)2.37233662
47Capillary hemangiomas (HP:0005306)2.36181397
48Abnormality of the carotid arteries (HP:0005344)2.34297933
49Clubbing of toes (HP:0100760)2.33243464
50Rough bone trabeculation (HP:0100670)2.32798275
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32760132
52Supernumerary spleens (HP:0009799)2.31979207
53Prominent nose (HP:0000448)2.30762670
54Embryonal renal neoplasm (HP:0011794)2.30662961
55Volvulus (HP:0002580)2.29870268
56Tracheoesophageal fistula (HP:0002575)2.29220410
57Deviation of the thumb (HP:0009603)2.28310505
58Horseshoe kidney (HP:0000085)2.27467998
59Proximal placement of thumb (HP:0009623)2.25629655
60Prostate neoplasm (HP:0100787)2.24483834
61Hypoplastic pelvis (HP:0008839)2.21827837
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18252045
63Atresia of the external auditory canal (HP:0000413)2.17425999
64Squamous cell carcinoma (HP:0002860)2.17115282
65Short 4th metacarpal (HP:0010044)2.14218096
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14218096
67Neoplasm of the pancreas (HP:0002894)2.13778743
68Oligodactyly (hands) (HP:0001180)2.12302024
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11741928
70Neoplasm of the colon (HP:0100273)2.11388122
71Triphalangeal thumb (HP:0001199)2.07717860
72Duplicated collecting system (HP:0000081)2.07039895
73Breast aplasia (HP:0100783)2.05627738
74Secondary amenorrhea (HP:0000869)2.02620987
75Abnormality of the phalanges of the hallux (HP:0010057)2.01914318
76Premature graying of hair (HP:0002216)2.00681284
77Oligodactyly (HP:0012165)1.99204178
78Facial cleft (HP:0002006)1.98977372
79Abnormal number of incisors (HP:0011064)1.98377662
80High pitched voice (HP:0001620)1.97475667
81Microretrognathia (HP:0000308)1.97137553
82Aplasia/Hypoplasia of the breasts (HP:0010311)1.96431644
83Overlapping toe (HP:0001845)1.94969822
84Acute myeloid leukemia (HP:0004808)1.94935266
85Slender long bone (HP:0003100)1.93556136
86Cerebral hypomyelination (HP:0006808)1.92785755
87Median cleft lip (HP:0000161)1.90533352
88Neoplasm of striated muscle (HP:0009728)1.88673285
89Abnormality of abdominal situs (HP:0011620)1.88409544
90Abdominal situs inversus (HP:0003363)1.88409544
91Embryonal neoplasm (HP:0002898)1.86847296
92Abnormality of the fingertips (HP:0001211)1.84589033
93Shawl scrotum (HP:0000049)1.84199977
94Duplication of thumb phalanx (HP:0009942)1.83388071
95Microglossia (HP:0000171)1.83139089
96Abnormality of the renal collecting system (HP:0004742)1.82851505
97Abnormal spermatogenesis (HP:0008669)1.82735382
98Basal cell carcinoma (HP:0002671)1.82083896
99Abnormal umbilical cord blood vessels (HP:0011403)1.81558814
100Single umbilical artery (HP:0001195)1.81558814
101Abnormality of the fetal cardiovascular system (HP:0010948)1.81558814
102Increased hepatocellular lipid droplets (HP:0006565)1.81441143
103Aplastic anemia (HP:0001915)1.80992689
104Sandal gap (HP:0001852)1.80105601
105Neoplasm of the oral cavity (HP:0100649)1.78666224
106Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77791736
107Arteriovenous malformation (HP:0100026)1.77507880
108Multiple enchondromatosis (HP:0005701)1.77367356
109Microtia (HP:0008551)1.76623330
110Abnormal trabecular bone morphology (HP:0100671)1.75847280
111Aplasia/hypoplasia of the humerus (HP:0006507)1.75794268
112Microvesicular hepatic steatosis (HP:0001414)1.75633924
113Abnormal auditory evoked potentials (HP:0006958)1.75560113
114Cortical dysplasia (HP:0002539)1.75195759
115Cleft eyelid (HP:0000625)1.74833025
116Astrocytoma (HP:0009592)1.73933605
117Abnormality of the astrocytes (HP:0100707)1.73933605
118Cellular immunodeficiency (HP:0005374)1.73817791
119Glioma (HP:0009733)1.73665115
120Short tibia (HP:0005736)1.72339814
121Abnormality of chromosome segregation (HP:0002916)1.72280930
122Ankle contracture (HP:0006466)1.71870858
123Choanal atresia (HP:0000453)1.71643924
124Increased serum pyruvate (HP:0003542)1.70183378
125Abnormality of the umbilical cord (HP:0010881)1.69403681
126Abnormality of methionine metabolism (HP:0010901)1.68181669
127Bifid tongue (HP:0010297)1.66448101
128Progressive muscle weakness (HP:0003323)1.66119621
129Deep philtrum (HP:0002002)1.65653410
130Megaloblastic anemia (HP:0001889)1.63974578
131Gonadotropin excess (HP:0000837)1.63850002
132Abnormality of glycolysis (HP:0004366)1.62633029
133Stillbirth (HP:0003826)1.61417631
134Short middle phalanx of the 5th finger (HP:0004220)1.59361596
135Abnormality of the pons (HP:0007361)1.56686159
136Macrocytic anemia (HP:0001972)1.56438673
137Hypoplasia of the pons (HP:0012110)1.55942830
138Shoulder girdle muscle weakness (HP:0003547)1.54031445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59149536
2CDC74.57321174
3WEE14.25173652
4NEK23.56919060
5TTK3.30364713
6BRSK23.02711260
7PLK42.99244883
8EIF2AK12.84635113
9SRPK12.54827097
10PLK12.46381828
11VRK22.40198067
12NEK12.38975271
13CDK122.24472632
14ACVR1B2.08017034
15AURKB2.02975446
16CHEK21.93003587
17STK101.87315093
18PLK31.83632242
19BRSK11.80721378
20ATR1.57593149
21CDK71.57380406
22MAP3K81.56181518
23MST41.54191366
24STK38L1.53062737
25TAF11.52482678
26MKNK11.50628389
27LATS11.49173200
28RPS6KA41.49053049
29CDK41.46161793
30EIF2AK31.45752480
31STK41.45470795
32STK31.45272023
33CHEK11.43432050
34LATS21.38773865
35VRK11.38341359
36TRIM281.34727128
37NME21.34135408
38TESK21.31557633
39AURKA1.30430775
40DYRK31.27197289
41MET1.25535676
42MELK1.21990355
43MKNK21.19857849
44CCNB11.18249876
45PASK1.11952017
46TLK11.09915915
47EIF2AK21.03577234
48ATM1.03242237
49BRAF1.01307866
50PIM10.99226272
51ZAK0.98179226
52RPS6KB20.92598252
53TSSK60.90063707
54* CDK20.90034473
55MAP3K90.82187488
56CDK60.81776050
57TNIK0.79289108
58EEF2K0.77108226
59CDK10.76583150
60NME10.75864608
61PAK40.74582459
62EPHA20.73728705
63CDK80.73433157
64ARAF0.66431663
65PLK20.65012721
66MARK30.63935375
67PAK10.61369410
68PBK0.61033180
69ALK0.57855635
70BRD40.57834616
71MOS0.56870899
72SCYL20.56124556
73MST1R0.54921129
74ERBB30.53699376
75BCR0.52558957
76STK240.48637730
77CSNK2A10.48319636
78NEK60.48007678
79PDK20.47660583
80CSNK2A20.45733145
81BMPR1B0.45306530
82CDK180.45084656
83CDK90.44408866
84MAP3K100.43847490
85CDK11A0.42816982
86CDK150.42775491
87TGFBR10.42694620
88CSNK1G10.42473100
89STK160.42115079
90PKN20.41889357
91LRRK20.40827358
92CLK10.40688090
93KSR10.40637883
94MAP3K60.40303807
95PRKCI0.40210022
96PTK20.40104577
97RPS6KA50.39481975
98CDK140.38993996
99NEK90.38230402
100MTOR0.37376310
101ILK0.35625627
102PAK20.35604965
103PNCK0.35454612
104CHUK0.32884462
105CSNK1G30.32808436
106ABL20.32160987
107NUAK10.31610314
108LIMK10.30438949
109DMPK0.30190917
110MAPK140.29725368
111TAOK30.29089160
112ERBB40.28782508
113RAF10.28051931
114PRKDC0.27571418
115JAK30.27029573
116FGFR10.26745990
117CSNK1E0.26025262
118MAP4K10.25652108
119FLT30.24108947
120CSNK1D0.23528820
121AKT20.21658253
122AKT10.21485563
123MAPK10.17820588
124GSK3B0.17139782
125IKBKB0.16276370
126MAP3K50.16200664
127TTN0.15913248
128DYRK20.15476290
129CDK30.15138068

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46736610
2Mismatch repair_Homo sapiens_hsa034303.92975368
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77551953
4Cell cycle_Homo sapiens_hsa041103.61393442
5Homologous recombination_Homo sapiens_hsa034403.33667223
6RNA transport_Homo sapiens_hsa030133.29467964
7RNA polymerase_Homo sapiens_hsa030203.07926744
8Spliceosome_Homo sapiens_hsa030403.01434331
9Base excision repair_Homo sapiens_hsa034102.77628212
10Fanconi anemia pathway_Homo sapiens_hsa034602.76148138
11Nucleotide excision repair_Homo sapiens_hsa034202.69637202
12Basal transcription factors_Homo sapiens_hsa030222.45315247
13One carbon pool by folate_Homo sapiens_hsa006702.30307535
14p53 signaling pathway_Homo sapiens_hsa041152.21575002
15Proteasome_Homo sapiens_hsa030502.18302734
16Pyrimidine metabolism_Homo sapiens_hsa002402.15705737
17Non-homologous end-joining_Homo sapiens_hsa034502.15540185
18RNA degradation_Homo sapiens_hsa030182.11759021
19Ribosome_Homo sapiens_hsa030101.92993729
20mRNA surveillance pathway_Homo sapiens_hsa030151.91786098
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77988561
22Protein export_Homo sapiens_hsa030601.66628896
23Oocyte meiosis_Homo sapiens_hsa041141.47827669
24Vitamin B6 metabolism_Homo sapiens_hsa007501.47822954
25Systemic lupus erythematosus_Homo sapiens_hsa053221.44998044
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42892032
27Epstein-Barr virus infection_Homo sapiens_hsa051691.33232961
28Pyruvate metabolism_Homo sapiens_hsa006201.23944222
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23268292
30Viral carcinogenesis_Homo sapiens_hsa052031.21786417
31Herpes simplex infection_Homo sapiens_hsa051681.20480880
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20407965
33MicroRNAs in cancer_Homo sapiens_hsa052061.17152127
34Purine metabolism_Homo sapiens_hsa002301.14280196
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13823960
36Huntingtons disease_Homo sapiens_hsa050161.08590850
37Parkinsons disease_Homo sapiens_hsa050121.07414381
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02562202
39Antigen processing and presentation_Homo sapiens_hsa046120.98968034
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97031291
41Oxidative phosphorylation_Homo sapiens_hsa001900.96644772
42Small cell lung cancer_Homo sapiens_hsa052220.95054250
43HTLV-I infection_Homo sapiens_hsa051660.92899141
44Propanoate metabolism_Homo sapiens_hsa006400.88131654
45Steroid biosynthesis_Homo sapiens_hsa001000.82259626
46Carbon metabolism_Homo sapiens_hsa012000.76492919
47Fatty acid elongation_Homo sapiens_hsa000620.75732872
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74972439
49Pentose phosphate pathway_Homo sapiens_hsa000300.74407949
50TGF-beta signaling pathway_Homo sapiens_hsa043500.71305769
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69212356
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67818875
53Thyroid cancer_Homo sapiens_hsa052160.67290710
54Apoptosis_Homo sapiens_hsa042100.67255276
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67075369
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.65195392
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62378034
58Folate biosynthesis_Homo sapiens_hsa007900.61682909
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60095192
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59912350
61Colorectal cancer_Homo sapiens_hsa052100.58471591
62Hepatitis B_Homo sapiens_hsa051610.58175785
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.55848081
64Legionellosis_Homo sapiens_hsa051340.55456789
65Selenocompound metabolism_Homo sapiens_hsa004500.54983357
66Pancreatic cancer_Homo sapiens_hsa052120.54008658
67Alzheimers disease_Homo sapiens_hsa050100.52401522
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52259597
69Wnt signaling pathway_Homo sapiens_hsa043100.52197119
70Measles_Homo sapiens_hsa051620.52125735
71Hippo signaling pathway_Homo sapiens_hsa043900.51930119
72Influenza A_Homo sapiens_hsa051640.51641066
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51265447
74Chronic myeloid leukemia_Homo sapiens_hsa052200.50171465
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.48326256
76Biosynthesis of amino acids_Homo sapiens_hsa012300.47549180
77Notch signaling pathway_Homo sapiens_hsa043300.44238931
78Shigellosis_Homo sapiens_hsa051310.43639866
79Primary immunodeficiency_Homo sapiens_hsa053400.42672518
80Adherens junction_Homo sapiens_hsa045200.42132841
81N-Glycan biosynthesis_Homo sapiens_hsa005100.41900966
82FoxO signaling pathway_Homo sapiens_hsa040680.40815130
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40708718
84Alcoholism_Homo sapiens_hsa050340.39890318
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38987981
86mTOR signaling pathway_Homo sapiens_hsa041500.37867319
87Prostate cancer_Homo sapiens_hsa052150.36421856
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.35130570
89Pathways in cancer_Homo sapiens_hsa052000.34623043
90Viral myocarditis_Homo sapiens_hsa054160.34469175
91Metabolic pathways_Homo sapiens_hsa011000.34388026
92Basal cell carcinoma_Homo sapiens_hsa052170.33074746
93Hematopoietic cell lineage_Homo sapiens_hsa046400.32479155
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.31603572
95Leishmaniasis_Homo sapiens_hsa051400.30566177
96HIF-1 signaling pathway_Homo sapiens_hsa040660.28858162
97Tight junction_Homo sapiens_hsa045300.28633409
98Bladder cancer_Homo sapiens_hsa052190.27399709
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27309647
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27077691
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26941396
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25375467
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25259407
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25116367
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23954599
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23891794
107Non-small cell lung cancer_Homo sapiens_hsa052230.23449443
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23307991
109Glutathione metabolism_Homo sapiens_hsa004800.23036039
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22725537
111Graft-versus-host disease_Homo sapiens_hsa053320.21416291
112Lysine degradation_Homo sapiens_hsa003100.21262291
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20480534
114Sulfur relay system_Homo sapiens_hsa041220.20275410
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19857578
116Gap junction_Homo sapiens_hsa045400.19777376
117Allograft rejection_Homo sapiens_hsa053300.19130676
118Arginine and proline metabolism_Homo sapiens_hsa003300.18088023
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.17621740
120Proteoglycans in cancer_Homo sapiens_hsa052050.16975366
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.16957837
122Endometrial cancer_Homo sapiens_hsa052130.15918917
123TNF signaling pathway_Homo sapiens_hsa046680.15865890
124Toxoplasmosis_Homo sapiens_hsa051450.15635709
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15547618
126Hedgehog signaling pathway_Homo sapiens_hsa043400.15299726
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15219989
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15025211
129Melanoma_Homo sapiens_hsa052180.14775801
130Acute myeloid leukemia_Homo sapiens_hsa052210.14413202
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14127220
132Cardiac muscle contraction_Homo sapiens_hsa042600.13728830
133Regulation of autophagy_Homo sapiens_hsa041400.13402551
134ECM-receptor interaction_Homo sapiens_hsa045120.12954846
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12336847
136Sulfur metabolism_Homo sapiens_hsa009200.11224507
137Caffeine metabolism_Homo sapiens_hsa002320.10867858

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