SPDYA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.10118866
2fusion of sperm to egg plasma membrane (GO:0007342)8.44807071
3piRNA metabolic process (GO:0034587)7.41754449
4cell wall macromolecule catabolic process (GO:0016998)6.89969227
5cell wall macromolecule metabolic process (GO:0044036)6.89969227
6sperm-egg recognition (GO:0035036)6.88578148
7acrosome assembly (GO:0001675)6.81609322
8multicellular organism reproduction (GO:0032504)6.60545447
9sperm motility (GO:0030317)6.60351423
10axonemal dynein complex assembly (GO:0070286)6.43530411
11plasma membrane fusion (GO:0045026)6.38102018
12binding of sperm to zona pellucida (GO:0007339)6.31235649
13* male meiosis (GO:0007140)6.08149010
14cell-cell recognition (GO:0009988)6.05996478
15synaptonemal complex organization (GO:0070193)6.04812157
16motile cilium assembly (GO:0044458)6.03968273
17spermatid development (GO:0007286)5.96159864
18synaptonemal complex assembly (GO:0007130)5.79745306
19DNA synthesis involved in DNA repair (GO:0000731)5.65108863
20epithelial cilium movement (GO:0003351)5.63211110
21acrosome reaction (GO:0007340)5.58026334
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.24746710
23male meiosis I (GO:0007141)5.22423066
24reproduction (GO:0000003)5.18201686
25DNA double-strand break processing (GO:0000729)5.03776612
26resolution of meiotic recombination intermediates (GO:0000712)5.02011342
27DNA methylation involved in gamete generation (GO:0043046)5.01929025
28regulation of cilium movement (GO:0003352)4.79645291
29meiosis I (GO:0007127)4.71926479
30cilium movement (GO:0003341)4.51089024
31chromosome organization involved in meiosis (GO:0070192)4.50768567
32* meiotic nuclear division (GO:0007126)4.50543297
33single fertilization (GO:0007338)4.34986958
34regulation of DNA endoreduplication (GO:0032875)4.21194723
35microtubule depolymerization (GO:0007019)4.01886609
36DNA deamination (GO:0045006)3.91077034
37histone H2A acetylation (GO:0043968)3.87417880
38monoubiquitinated protein deubiquitination (GO:0035520)3.85684439
39fertilization (GO:0009566)3.81216665
40meiotic cell cycle (GO:0051321)3.79657613
41response to pheromone (GO:0019236)3.78246665
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.71706505
43meiotic chromosome segregation (GO:0045132)3.64586537
44DNA catabolic process, exonucleolytic (GO:0000738)3.60016651
45proteasome assembly (GO:0043248)3.59353997
46replication fork processing (GO:0031297)3.56548041
47histone exchange (GO:0043486)3.54142183
48spermatid nucleus differentiation (GO:0007289)3.52778748
49purine nucleobase biosynthetic process (GO:0009113)3.51503505
50positive regulation of meiosis (GO:0045836)3.51336570
51spermatogenesis (GO:0007283)3.41259174
52male gamete generation (GO:0048232)3.41118413
53negative regulation of inclusion body assembly (GO:0090084)3.36444278
54germ cell development (GO:0007281)3.33719307
55meiotic cell cycle process (GO:1903046)3.33644730
56regulation of meiosis I (GO:0060631)3.32437253
57positive regulation of meiotic cell cycle (GO:0051446)3.31822730
58recombinational repair (GO:0000725)3.26710148
592-deoxyribonucleotide biosynthetic process (GO:0009265)3.25885819
60deoxyribose phosphate biosynthetic process (GO:0046385)3.25885819
61double-strand break repair via homologous recombination (GO:0000724)3.25613302
62nucleobase biosynthetic process (GO:0046112)3.25182663
63cellular process involved in reproduction in multicellular organism (GO:0022412)3.22193352
64DNA replication checkpoint (GO:0000076)3.21199229
65sperm capacitation (GO:0048240)3.21171008
66positive regulation of response to oxidative stress (GO:1902884)3.17135934
67positive regulation of cellular response to oxidative stress (GO:1900409)3.17135934
68adenosine metabolic process (GO:0046085)3.15719519
69gamete generation (GO:0007276)3.13900897
70rRNA methylation (GO:0031167)3.13552471
71guanosine-containing compound biosynthetic process (GO:1901070)3.12484263
72attachment of spindle microtubules to kinetochore (GO:0008608)3.10757776
73deoxyribonucleotide biosynthetic process (GO:0009263)3.06712826
74synapsis (GO:0007129)3.05336165
75axoneme assembly (GO:0035082)3.04207913
76rRNA modification (GO:0000154)3.03654478
77nuclear pore organization (GO:0006999)3.02144254
78protein complex biogenesis (GO:0070271)3.02086008
79respiratory chain complex IV assembly (GO:0008535)3.01843729
80gene silencing by RNA (GO:0031047)2.98896097
81sister chromatid cohesion (GO:0007062)2.97907849
82negative regulation of telomere maintenance (GO:0032205)2.94722707
83chromatin remodeling at centromere (GO:0031055)2.93079233
84ribosome biogenesis (GO:0042254)2.91820765
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90359097
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.90359097
87NADH dehydrogenase complex assembly (GO:0010257)2.90359097
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90250750
89regulation of nuclear cell cycle DNA replication (GO:0033262)2.89756513
90nuclear pore complex assembly (GO:0051292)2.88122587
91mitochondrial respiratory chain complex assembly (GO:0033108)2.86372350
92intraciliary transport (GO:0042073)2.85341096
93regulation of spindle checkpoint (GO:0090231)2.81447675
94CENP-A containing nucleosome assembly (GO:0034080)2.81376242
95DNA damage response, detection of DNA damage (GO:0042769)2.80680665
96regulation of helicase activity (GO:0051095)2.79609896
97centriole replication (GO:0007099)2.78670142
98nucleus organization (GO:0006997)2.77837685
99protein localization to cilium (GO:0061512)2.75559923
100mitotic metaphase plate congression (GO:0007080)2.75426472
101regulation of centriole replication (GO:0046599)2.75348080
102translesion synthesis (GO:0019985)2.75254572
103photoreceptor cell maintenance (GO:0045494)2.75153663
104cullin deneddylation (GO:0010388)2.75110686
105calcium ion-dependent exocytosis (GO:0017156)2.74819301
106regulation of inclusion body assembly (GO:0090083)2.73870637
107protein deneddylation (GO:0000338)2.73427729
108telomere maintenance via telomerase (GO:0007004)2.72943408
109cytochrome complex assembly (GO:0017004)2.72764032
110seminiferous tubule development (GO:0072520)2.72103639
111mitotic sister chromatid cohesion (GO:0007064)2.71797252
112protein localization to chromosome, centromeric region (GO:0071459)2.71648392
113cilium morphogenesis (GO:0060271)2.71253725
114DNA strand elongation involved in DNA replication (GO:0006271)2.70704109
115mitochondrial RNA metabolic process (GO:0000959)2.70426644
116ventricular system development (GO:0021591)2.70250547
117spliceosomal snRNP assembly (GO:0000387)2.70136226
118DNA strand elongation (GO:0022616)2.69240792
119single strand break repair (GO:0000012)2.69118895
120centriole assembly (GO:0098534)2.69009386
121deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.68464024
122GTP biosynthetic process (GO:0006183)2.66564102
123reciprocal DNA recombination (GO:0035825)2.66475371
124reciprocal meiotic recombination (GO:0007131)2.66475371
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66144181
126postreplication repair (GO:0006301)2.65901291
127protein K11-linked deubiquitination (GO:0035871)2.65715187
128telomere maintenance via recombination (GO:0000722)2.65662983
129termination of RNA polymerase III transcription (GO:0006386)2.64880292
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.64880292
131DNA replication initiation (GO:0006270)2.63510376
132intra-S DNA damage checkpoint (GO:0031573)2.63315039
133telomere maintenance via semi-conservative replication (GO:0032201)2.62330675
134DNA replication-independent nucleosome organization (GO:0034724)2.62071551
135DNA replication-independent nucleosome assembly (GO:0006336)2.62071551
136female gamete generation (GO:0007292)2.61151540
137DNA packaging (GO:0006323)2.60441307
138UTP biosynthetic process (GO:0006228)2.60251410
139termination of RNA polymerase I transcription (GO:0006363)2.60179315
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.60142990
141regulation of meiotic cell cycle (GO:0051445)2.59168316
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58754314
143regulation of mitotic spindle checkpoint (GO:1903504)2.58754314
144establishment of protein localization to Golgi (GO:0072600)2.57502661
145neural tube formation (GO:0001841)2.56332209
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53702531
147regulation of telomere maintenance (GO:0032204)2.50751725
148DNA recombination (GO:0006310)2.47811307
149lactate metabolic process (GO:0006089)2.46894454
150preassembly of GPI anchor in ER membrane (GO:0016254)2.46772331
151nucleotide transmembrane transport (GO:1901679)2.45667496
152tRNA methylation (GO:0030488)2.44775017
153cilium organization (GO:0044782)2.44665781
154histone H2A ubiquitination (GO:0033522)2.44517441
155chromosome organization (GO:0051276)2.43709757
156signal peptide processing (GO:0006465)2.42579984
157DNA alkylation (GO:0006305)2.42227384
158DNA methylation (GO:0006306)2.42227384
159prenylation (GO:0097354)2.41236968
160protein prenylation (GO:0018342)2.41236968
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41156893
162DNA replication-dependent nucleosome organization (GO:0034723)2.41151785
163DNA replication-dependent nucleosome assembly (GO:0006335)2.41151785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.29725226
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.61154775
3E2F7_22180533_ChIP-Seq_HELA_Human4.52210935
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56737654
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.37804265
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.13128851
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10074717
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.05789423
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.83075140
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75157885
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71902437
12FUS_26573619_Chip-Seq_HEK293_Human2.63112679
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61668371
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55986162
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52417179
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.44532670
17VDR_23849224_ChIP-Seq_CD4+_Human2.36253699
18IGF1R_20145208_ChIP-Seq_DFB_Human2.34737812
19EWS_26573619_Chip-Seq_HEK293_Human2.32066228
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31801591
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28818459
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24544135
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22267766
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18359334
25TAF15_26573619_Chip-Seq_HEK293_Human2.15564152
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13388888
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13000172
28GBX2_23144817_ChIP-Seq_PC3_Human2.05012668
29ER_23166858_ChIP-Seq_MCF-7_Human2.03932842
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03885218
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01655111
32* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.99497000
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97336619
34P300_19829295_ChIP-Seq_ESCs_Human1.94657997
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.94066103
36FOXP3_21729870_ChIP-Seq_TREG_Human1.90934591
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89714330
38DCP1A_22483619_ChIP-Seq_HELA_Human1.88263988
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86501413
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83768434
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83324519
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82633406
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80928037
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80780492
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79978869
46GABP_19822575_ChIP-Seq_HepG2_Human1.79835449
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.74872445
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72816559
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68254170
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66528047
51CBP_20019798_ChIP-Seq_JUKART_Human1.65632314
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65632314
53XRN2_22483619_ChIP-Seq_HELA_Human1.65566415
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62313577
55MYC_18940864_ChIP-ChIP_HL60_Human1.58337829
56BCAT_22108803_ChIP-Seq_LS180_Human1.56272612
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.55683113
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54094762
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53040420
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52992238
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51444900
62ELK1_19687146_ChIP-ChIP_HELA_Human1.49710993
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.45667457
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44887723
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44591698
66STAT3_23295773_ChIP-Seq_U87_Human1.44372329
67AR_25329375_ChIP-Seq_VCAP_Human1.43189604
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41663855
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41348014
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40905894
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40868195
72TTF2_22483619_ChIP-Seq_HELA_Human1.40494932
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40458385
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40131504
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39118480
76SMAD4_21799915_ChIP-Seq_A2780_Human1.33567308
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33449281
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32581358
79TCF4_23295773_ChIP-Seq_U87_Human1.29324710
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28741184
81RNF2_27304074_Chip-Seq_NSC_Mouse1.27715156
82NANOG_19829295_ChIP-Seq_ESCs_Human1.27629293
83SOX2_19829295_ChIP-Seq_ESCs_Human1.27629293
84TCF4_22108803_ChIP-Seq_LS180_Human1.27420913
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.27187865
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26977953
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26566444
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26504012
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.25799636
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25677277
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25570309
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.24657251
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24173663
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23420457
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22681761
96* YY1_21170310_ChIP-Seq_MESCs_Mouse1.21287022
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20032109
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19382879
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.19164376
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18495757
101RUNX2_22187159_ChIP-Seq_PCA_Human1.18363584
102CDX2_22108803_ChIP-Seq_LS180_Human1.17819197
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17486039
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16293327
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15883253
106AR_21909140_ChIP-Seq_LNCAP_Human1.15539132
107KDM5A_27292631_Chip-Seq_BREAST_Human1.15041332
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.14928089
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13670772
110* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13665658
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13397000
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12812544
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.12054296
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.12032745
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.11315828
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11315828
117* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10504631
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.10377089
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09760072
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09252650
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09252650
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.08462659
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08225605
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07220812
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05914049
126P53_22387025_ChIP-Seq_ESCs_Mouse1.05749495
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05374161
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.05169124
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04597372
130EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03641162
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03535087
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01824105
133ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01820038
134AR_20517297_ChIP-Seq_VCAP_Human1.01397824
135P300_18555785_Chip-Seq_ESCs_Mouse1.01111999
136* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01100931
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00598748
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98944677
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98473360
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94431626
141GATA3_21867929_ChIP-Seq_CD8_Mouse0.94429849
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.92826317
143VDR_22108803_ChIP-Seq_LS180_Human0.92040944
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91519375
145GATA3_21867929_ChIP-Seq_TH1_Mouse0.90893670
146IRF1_19129219_ChIP-ChIP_H3396_Human0.86894516
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86295128
148SPI1_23547873_ChIP-Seq_NB4_Human0.84649205
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84647369
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84401081
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83018305
152* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81828902
153ERG_20517297_ChIP-Seq_VCAP_Human0.81687503
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80388113
155ZNF274_21170338_ChIP-Seq_K562_Hela0.80354630
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.79310505
157SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78719803
158MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77583705
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76580881
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.76493463
161FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76085299
162TP53_22573176_ChIP-Seq_HFKS_Human0.74932138
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74685229
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72985808
165NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72157491
166GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71049532
167CRX_20693478_ChIP-Seq_RETINA_Mouse0.69431620
168ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69313720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.98040744
2MP0008877_abnormal_DNA_methylation5.76629161
3MP0003693_abnormal_embryo_hatching4.55292843
4MP0001929_abnormal_gametogenesis3.98880565
5MP0008057_abnormal_DNA_replication3.88674561
6MP0003698_abnormal_male_reproductive3.86161894
7MP0010094_abnormal_chromosome_stability3.56014634
8MP0002210_abnormal_sex_determination3.32215653
9MP0008058_abnormal_DNA_repair3.27471330
10MP0001145_abnormal_male_reproductive2.74096267
11MP0003111_abnormal_nucleus_morphology2.69875773
12MP0004957_abnormal_blastocyst_morpholog2.67417680
13MP0000653_abnormal_sex_gland2.46226978
14MP0001986_abnormal_taste_sensitivity2.44875900
15MP0008007_abnormal_cellular_replicative2.43421926
16MP0003077_abnormal_cell_cycle2.43256001
17MP0002161_abnormal_fertility/fecundity2.18583072
18MP0003786_premature_aging2.07773642
19MP0000427_abnormal_hair_cycle2.06904764
20MP0000372_irregular_coat_pigmentation1.91667832
21MP0003183_abnormal_peptide_metabolism1.88053837
22MP0001984_abnormal_olfaction1.67489877
23MP0005551_abnormal_eye_electrophysiolog1.67306584
24MP0006072_abnormal_retinal_apoptosis1.66312739
25MP0002653_abnormal_ependyma_morphology1.66077477
26MP0002160_abnormal_reproductive_system1.58062690
27MP0003646_muscle_fatigue1.57335515
28MP0002938_white_spotting1.56015548
29MP0000383_abnormal_hair_follicle1.51399176
30MP0003123_paternal_imprinting1.49612704
31MP0003724_increased_susceptibility_to1.46733965
32MP0009697_abnormal_copulation1.46624835
33MP0002736_abnormal_nociception_after1.41220299
34MP0002009_preneoplasia1.40293449
35MP0000569_abnormal_digit_pigmentation1.40049282
36MP0008932_abnormal_embryonic_tissue1.35870697
37MP0003718_maternal_effect1.35835211
38MP0002163_abnormal_gland_morphology1.34074207
39MP0000516_abnormal_urinary_system1.32949049
40MP0005367_renal/urinary_system_phenotyp1.32949049
41MP0009046_muscle_twitch1.32509823
42MP0008260_abnormal_autophagy1.31308626
43MP0004808_abnormal_hematopoietic_stem1.27607876
44MP0005253_abnormal_eye_physiology1.26225753
45MP0010678_abnormal_skin_adnexa1.25080340
46MP0001764_abnormal_homeostasis1.23643667
47MP0000647_abnormal_sebaceous_gland1.22628593
48MP0003880_abnormal_central_pattern1.22586400
49MP0003806_abnormal_nucleotide_metabolis1.22022124
50MP0004133_heterotaxia1.17859209
51MP0001968_abnormal_touch/_nociception1.16061744
52MP0005084_abnormal_gallbladder_morpholo1.15692098
53MP0005646_abnormal_pituitary_gland1.15658230
54MP0000358_abnormal_cell_content/1.14997106
55MP0000631_abnormal_neuroendocrine_gland1.13318968
56MP0000015_abnormal_ear_pigmentation1.12212630
57MP0008872_abnormal_physiological_respon1.11158621
58MP0002234_abnormal_pharynx_morphology1.10845418
59MP0001545_abnormal_hematopoietic_system1.10019082
60MP0005397_hematopoietic_system_phenotyp1.10019082
61MP0006036_abnormal_mitochondrial_physio1.09170354
62MP0008875_abnormal_xenobiotic_pharmacok1.08894454
63MP0005389_reproductive_system_phenotype1.08657460
64MP0005395_other_phenotype1.05811918
65MP0004147_increased_porphyrin_level1.02977289
66MP0003950_abnormal_plasma_membrane1.02696210
67MP0009785_altered_susceptibility_to1.02375529
68MP0004215_abnormal_myocardial_fiber1.02060572
69MP0001119_abnormal_female_reproductive1.01524779
70MP0000313_abnormal_cell_death0.96440443
71MP0005671_abnormal_response_to0.96058490
72MP0002396_abnormal_hematopoietic_system0.92921507
73MP0005645_abnormal_hypothalamus_physiol0.92594701
74MP0002398_abnormal_bone_marrow0.91768102
75MP0003763_abnormal_thymus_physiology0.91552950
76MP0006035_abnormal_mitochondrial_morpho0.90848797
77MP0002148_abnormal_hypersensitivity_rea0.90759217
78MP0009745_abnormal_behavioral_response0.89880695
79MP0008995_early_reproductive_senescence0.89645373
80MP0010307_abnormal_tumor_latency0.88509414
81MP0010386_abnormal_urinary_bladder0.87520660
82MP0003121_genomic_imprinting0.87019408
83MP0002638_abnormal_pupillary_reflex0.86301453
84MP0006276_abnormal_autonomic_nervous0.85791622
85MP0002019_abnormal_tumor_incidence0.85720525
86MP0005174_abnormal_tail_pigmentation0.84632098
87MP0005310_abnormal_salivary_gland0.84250270
88MP0004043_abnormal_pH_regulation0.84090326
89MP0000689_abnormal_spleen_morphology0.83616413
90MP0000350_abnormal_cell_proliferation0.83499200
91MP0001730_embryonic_growth_arrest0.83112795
92MP0002138_abnormal_hepatobiliary_system0.82856198
93MP0002837_dystrophic_cardiac_calcinosis0.82199348
94MP0005075_abnormal_melanosome_morpholog0.82092584
95MP0005647_abnormal_sex_gland0.82089872
96MP0001485_abnormal_pinna_reflex0.81991929
97MP0001501_abnormal_sleep_pattern0.81881925
98MP0002723_abnormal_immune_serum0.80951048
99MP0002282_abnormal_trachea_morphology0.80808624
100MP0001486_abnormal_startle_reflex0.80695611
101MP0002876_abnormal_thyroid_physiology0.80080214
102MP0005332_abnormal_amino_acid0.79433776
103MP0002928_abnormal_bile_duct0.79081532
104MP0001835_abnormal_antigen_presentation0.79017720
105MP0003937_abnormal_limbs/digits/tail_de0.78221693
106MP0000490_abnormal_crypts_of0.76301739
107MP0001529_abnormal_vocalization0.75972185
108MP0002751_abnormal_autonomic_nervous0.75418808
109MP0005000_abnormal_immune_tolerance0.75085262
110MP0002277_abnormal_respiratory_mucosa0.74658359
111MP0002095_abnormal_skin_pigmentation0.73558509
112MP0002420_abnormal_adaptive_immunity0.73403173
113MP0004142_abnormal_muscle_tone0.73285071
114MP0005379_endocrine/exocrine_gland_phen0.72817246
115MP0003436_decreased_susceptibility_to0.72540335
116MP0003699_abnormal_female_reproductive0.72114541
117MP0001819_abnormal_immune_cell0.71878524
118MP0001800_abnormal_humoral_immune0.71842507
119MP0002452_abnormal_antigen_presenting0.69615146
120MP0005025_abnormal_response_to0.69590168
121MP0006054_spinal_hemorrhage0.69504280
122MP0002722_abnormal_immune_system0.68958352
123MP0002735_abnormal_chemical_nociception0.67807914
124MP0000703_abnormal_thymus_morphology0.67664728
125MP0000716_abnormal_immune_system0.67578678
126MP0002080_prenatal_lethality0.67357882
127MP0002693_abnormal_pancreas_physiology0.66750290
128MP0002429_abnormal_blood_cell0.66612332
129MP0003136_yellow_coat_color0.66559562
130MP0008789_abnormal_olfactory_epithelium0.65689716
131MP0002405_respiratory_system_inflammati0.65060220
132MP0002233_abnormal_nose_morphology0.64945882
133MP0005386_behavior/neurological_phenoty0.64894125
134MP0004924_abnormal_behavior0.64894125
135MP0002272_abnormal_nervous_system0.64743756
136MP0003787_abnormal_imprinting0.64154222
137MP0009333_abnormal_splenocyte_physiolog0.63884466
138MP0001697_abnormal_embryo_size0.63519986
139MP0001661_extended_life_span0.63398882
140MP0002132_abnormal_respiratory_system0.63348792
141MP0003186_abnormal_redox_activity0.63343281
142MP0003195_calcinosis0.62791578
143MP0001542_abnormal_bone_strength0.62395704
144MP0002102_abnormal_ear_morphology0.61790118
145MP0001919_abnormal_reproductive_system0.61372241
146MP0003943_abnormal_hepatobiliary_system0.61108940
147MP0002419_abnormal_innate_immunity0.60768030
148MP0001853_heart_inflammation0.60415410
149MP0003879_abnormal_hair_cell0.59223282
150MP0005058_abnormal_lysosome_morphology0.57188218
151MP0006292_abnormal_olfactory_placode0.55380277
152MP0005257_abnormal_intraocular_pressure0.54670705

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.07118437
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.48181106
3Absent/shortened dynein arms (HP:0200106)8.48181106
4Abnormal respiratory epithelium morphology (HP:0012253)6.08793033
5Abnormal respiratory motile cilium morphology (HP:0005938)6.08793033
6Abnormal respiratory motile cilium physiology (HP:0012261)6.06675453
7Rhinitis (HP:0012384)5.63932254
8Chronic bronchitis (HP:0004469)5.34992231
9Abnormal ciliary motility (HP:0012262)4.74478478
10Nasal polyposis (HP:0100582)4.50404926
11Infertility (HP:0000789)4.34185037
12Abnormality of the anterior horn cell (HP:0006802)4.13712378
13Degeneration of anterior horn cells (HP:0002398)4.13712378
14Abnormal spermatogenesis (HP:0008669)3.83756138
15Medial flaring of the eyebrow (HP:0010747)3.76293096
16Bronchitis (HP:0012387)3.62169211
17Volvulus (HP:0002580)3.61151989
18Abnormality of the nasal mucosa (HP:0000433)3.49211362
19Bronchiectasis (HP:0002110)3.44141661
20Nephronophthisis (HP:0000090)3.38932523
21Impulsivity (HP:0100710)3.24278883
22Azoospermia (HP:0000027)3.14009500
23Chronic hepatic failure (HP:0100626)2.96712304
24Congenital primary aphakia (HP:0007707)2.87860970
25Gait imbalance (HP:0002141)2.77532542
2611 pairs of ribs (HP:0000878)2.76392554
27Abnormality of midbrain morphology (HP:0002418)2.73848831
28Molar tooth sign on MRI (HP:0002419)2.73848831
29Pancreatic fibrosis (HP:0100732)2.72971816
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.72082332
31Recurrent sinusitis (HP:0011108)2.71161431
32Birth length less than 3rd percentile (HP:0003561)2.65990865
33Gaze-evoked nystagmus (HP:0000640)2.63223355
34Nephrogenic diabetes insipidus (HP:0009806)2.62106105
35Methylmalonic acidemia (HP:0002912)2.58945698
36Abnormality of the labia minora (HP:0012880)2.52711165
37Gonadotropin excess (HP:0000837)2.52567700
38Abnormality of the lower motor neuron (HP:0002366)2.51213380
39Recurrent otitis media (HP:0000403)2.49299998
40Type II lissencephaly (HP:0007260)2.48789017
41Recurrent bronchitis (HP:0002837)2.46953864
42Oligodactyly (hands) (HP:0001180)2.45419284
43Abnormality of the renal medulla (HP:0100957)2.43910496
44Hypothermia (HP:0002045)2.43079022
45Congenital, generalized hypertrichosis (HP:0004540)2.40659493
46Increased CSF lactate (HP:0002490)2.38799670
47Pancreatic cysts (HP:0001737)2.37227097
48IgM deficiency (HP:0002850)2.36177417
49Facial cleft (HP:0002006)2.34395414
50Small intestinal stenosis (HP:0012848)2.29512432
51Duodenal stenosis (HP:0100867)2.29512432
52Fibular hypoplasia (HP:0003038)2.26128280
53Poor coordination (HP:0002370)2.25962168
54Median cleft lip (HP:0000161)2.25649331
55Abnormality of the preputium (HP:0100587)2.25401416
56Tongue fasciculations (HP:0001308)2.22795062
57Ectopic kidney (HP:0000086)2.22157233
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.19066308
59Absent epiphyses (HP:0010577)2.19066308
60Congenital stationary night blindness (HP:0007642)2.18202148
61Supernumerary spleens (HP:0009799)2.17208797
62Aplastic anemia (HP:0001915)2.16931729
63Methylmalonic aciduria (HP:0012120)2.12232608
64Tubulointerstitial nephritis (HP:0001970)2.11262802
65Abnormality of the duodenum (HP:0002246)2.09781783
66Rough bone trabeculation (HP:0100670)2.09761797
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.08738695
68Attenuation of retinal blood vessels (HP:0007843)2.07719649
69Fair hair (HP:0002286)2.06751991
70Mitochondrial inheritance (HP:0001427)2.05431654
71Hyperventilation (HP:0002883)2.04881563
72Cystic liver disease (HP:0006706)2.04099489
73Pancytopenia (HP:0001876)2.01875840
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01791438
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.01791438
76Occipital encephalocele (HP:0002085)2.01050710
77Impaired proprioception (HP:0010831)1.99468088
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99452084
79Abnormality of alanine metabolism (HP:0010916)1.99452084
80Hyperalaninemia (HP:0003348)1.99452084
81Progressive macrocephaly (HP:0004481)1.99339359
82Spontaneous abortion (HP:0005268)1.98200444
83Abnormal drinking behavior (HP:0030082)1.96262693
84Polydipsia (HP:0001959)1.96262693
85Postaxial foot polydactyly (HP:0001830)1.95732183
86Pulmonary fibrosis (HP:0002206)1.94219837
87Amyotrophic lateral sclerosis (HP:0007354)1.92916914
88Hypoplastic iliac wings (HP:0002866)1.92530645
89Abnormality of vitamin B metabolism (HP:0004340)1.90328719
90True hermaphroditism (HP:0010459)1.88263850
91Type I transferrin isoform profile (HP:0003642)1.87618355
92Muscle fibrillation (HP:0010546)1.85177439
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85064542
94Hepatocellular necrosis (HP:0001404)1.85057516
95Male pseudohermaphroditism (HP:0000037)1.84995365
96Meckel diverticulum (HP:0002245)1.84669565
97Oculomotor apraxia (HP:0000657)1.84356008
98Abnormality of chromosome stability (HP:0003220)1.83775206
99Widely spaced teeth (HP:0000687)1.83646008
100Oral leukoplakia (HP:0002745)1.83510235
101Chromsome breakage (HP:0040012)1.83470878
102Clubbing of toes (HP:0100760)1.83400266
103Abnormal hair whorl (HP:0010721)1.82836348
104Bone marrow hypocellularity (HP:0005528)1.82310583
105Increased hepatocellular lipid droplets (HP:0006565)1.82052532
106Increased serum lactate (HP:0002151)1.81719984
107Abnormal number of erythroid precursors (HP:0012131)1.81375752
108Chronic sinusitis (HP:0011109)1.81336219
109Abnormality of the pons (HP:0007361)1.81138695
110Abnormality of cells of the erythroid lineage (HP:0012130)1.80676480
111Horizontal nystagmus (HP:0000666)1.80037507
112Small hand (HP:0200055)1.79765848
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79688351
114Abnormal protein N-linked glycosylation (HP:0012347)1.79688351
115Abnormal protein glycosylation (HP:0012346)1.79688351
116Abnormal glycosylation (HP:0012345)1.79688351
117Gastrointestinal atresia (HP:0002589)1.78940026
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.78826421
119Sloping forehead (HP:0000340)1.78826380
120Abnormality of the vitamin B12 metabolism (HP:0004341)1.78709442
121Febrile seizures (HP:0002373)1.78678648
122Genital tract atresia (HP:0001827)1.78442826
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.78287999
124Renal Fanconi syndrome (HP:0001994)1.78254556
125Congenital hepatic fibrosis (HP:0002612)1.77874683
126Abnormality of the ileum (HP:0001549)1.77731905
127Increased serum pyruvate (HP:0003542)1.76044478
128Progressive inability to walk (HP:0002505)1.75433457
129Vaginal atresia (HP:0000148)1.75188008
130Sclerocornea (HP:0000647)1.74510287
131Optic neuritis (HP:0100653)1.73592541
132Retrobulbar optic neuritis (HP:0100654)1.73592541
133Abnormality of macular pigmentation (HP:0008002)1.72498465
134Spinal muscular atrophy (HP:0007269)1.72379485
135Hypoplasia of the pons (HP:0012110)1.72252828
136Inability to walk (HP:0002540)1.71824626
137Abnormality of renal resorption (HP:0011038)1.71691893
138Reduced antithrombin III activity (HP:0001976)1.71672419
139Hepatic necrosis (HP:0002605)1.71434256
140Aplasia/hypoplasia of the uterus (HP:0008684)1.70600131
141Abolished electroretinogram (ERG) (HP:0000550)1.70434683
142Preaxial hand polydactyly (HP:0001177)1.70323128
143Intestinal atresia (HP:0011100)1.70032610
144Upper motor neuron abnormality (HP:0002127)1.69582560
145Glucose intolerance (HP:0000833)1.69301203
146Muscle fiber atrophy (HP:0100295)1.68818614
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68472909
148Optic nerve hypoplasia (HP:0000609)1.68371677
149Abnormal trabecular bone morphology (HP:0100671)1.68268381
150Acute necrotizing encephalopathy (HP:0006965)1.67157135
151Microglossia (HP:0000171)1.65842364
152Hypoplasia of the radius (HP:0002984)1.65825716
153Breast hypoplasia (HP:0003187)1.63602806
1543-Methylglutaconic aciduria (HP:0003535)1.63261776
155Abnormality of the renal cortex (HP:0011035)1.60552508
156Tubular atrophy (HP:0000092)1.60317993
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.60072583
158Male infertility (HP:0003251)1.59912688
159Cleft eyelid (HP:0000625)1.59750185
160Type 2 muscle fiber atrophy (HP:0003554)1.59669064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.80588634
2PDK36.80588634
3PDK24.45477526
4MAP4K23.72866300
5BUB12.76340945
6WEE12.70447564
7CDC72.52026940
8STK162.46704412
9CCNB12.38884386
10NEK22.31680965
11EIF2AK12.26069160
12TRIM282.12989957
13BRSK22.05194874
14TESK12.03182835
15AKT32.02053276
16SRPK11.99002697
17OXSR11.82893329
18PLK41.82566650
19TSSK61.81722065
20MKNK21.79287607
21INSRR1.69378937
22WNK31.67147505
23EIF2AK31.60422688
24ACVR1B1.58488744
25CASK1.56506251
26NME21.52087000
27TNIK1.51349007
28BCR1.50639625
29MAP2K61.48775225
30DYRK31.47634527
31MAPK131.44698278
32VRK11.33841062
33BRAF1.33840360
34PASK1.30701682
35TAOK21.27654364
36MKNK11.24113279
37BMPR1B1.22221901
38PLK11.19012691
39GRK11.15839313
40ATR1.14432982
41RPS6KA41.11319541
42TTK1.07282782
43STK391.07208672
44FGFR21.06766273
45IRAK31.06749187
46STK31.06164418
47CHEK21.05428211
48PLK31.03654533
49BRSK11.01483729
50TXK0.98326053
51PBK0.98320375
52MAP3K40.97868647
53CDK40.93495089
54TAF10.89816201
55FRK0.84157235
56PIM20.83925219
57AURKB0.83797253
58EIF2AK20.82514217
59CHEK10.81302163
60PNCK0.81215154
61MUSK0.79453000
62PAK30.76931802
63CAMK1G0.70165916
64MAP3K50.69536010
65CAMKK20.68374152
66YES10.67340559
67PRKD30.66423025
68PTK2B0.64495078
69AURKA0.63389774
70PRKCE0.62452803
71MET0.58681352
72CSNK1G10.58431283
73LATS10.57130212
74CDK70.57092009
75NLK0.56905684
76CDK30.56631928
77WNK40.56249528
78PRKCI0.54794271
79CSNK2A10.54331987
80VRK20.51745580
81TAOK30.50221356
82JAK30.49210457
83SIK30.48539007
84STK40.48474304
85CSNK1G20.47984618
86CSNK2A20.47311559
87NEK10.47223870
88IRAK10.46961472
89ATM0.46953207
90TEC0.45333014
91CSNK1G30.43919123
92PIM10.43167778
93RPS6KB10.42439383
94MARK30.41519145
95PRKCG0.41433999
96PINK10.41009831
97FGR0.40060823
98TESK20.40010536
99ERBB30.38563111
100IKBKB0.38039564
101FER0.37359937
102EPHA40.37215121
103ZAP700.36816398
104NEK60.36640041
105EGFR0.36055813
106DAPK10.35228725
107TGFBR10.34702622
108PAK10.34354740
109CSF1R0.34003046
110CSNK1A1L0.33982719
111PRKG10.33748043
112MST40.33416914
113PKN10.33381660
114TYK20.33236040
115NEK90.32560305
116MAPKAPK50.32503926
117NME10.32118973
118MINK10.31886133
119MST1R0.31815213
120ADRBK10.31293300
121MAP4K10.30880185
122CDK20.30239781
123NUAK10.29967360
124MAP2K70.29373258
125PRPF4B0.28528916
126BRD40.28528780
127ZAK0.27750446
128MAPKAPK30.27698218
129SGK20.27522725
130TIE10.27366687
131PDK10.26165850
132CDK190.23719455
133STK38L0.22310483
134RIPK40.22256974
135CDK80.22216142
136CDK10.20977359
137TLK10.20385530
138ADRBK20.20253895
139BMPR20.19145216
140PLK20.18970726
141STK380.14689759
142DYRK1B0.14606088
143LYN0.14562155
144MAP3K140.14256850
145TBK10.14249921

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.99222336
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51366864
3Proteasome_Homo sapiens_hsa030503.41723293
4DNA replication_Homo sapiens_hsa030303.33937773
5Basal transcription factors_Homo sapiens_hsa030223.09564164
6Homologous recombination_Homo sapiens_hsa034403.01936573
7RNA polymerase_Homo sapiens_hsa030202.96727624
8RNA transport_Homo sapiens_hsa030132.77147231
9Fanconi anemia pathway_Homo sapiens_hsa034602.70790176
10Mismatch repair_Homo sapiens_hsa034302.69557842
11Pyrimidine metabolism_Homo sapiens_hsa002402.50895385
12Folate biosynthesis_Homo sapiens_hsa007902.36089752
13Sulfur relay system_Homo sapiens_hsa041222.29283257
14Nucleotide excision repair_Homo sapiens_hsa034202.25382765
15Spliceosome_Homo sapiens_hsa030402.24018340
16Protein export_Homo sapiens_hsa030602.22346638
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20397440
18Ribosome_Homo sapiens_hsa030102.10447207
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09421504
20Cell cycle_Homo sapiens_hsa041102.08958850
21Base excision repair_Homo sapiens_hsa034101.93534191
22Phototransduction_Homo sapiens_hsa047441.82680135
23Butanoate metabolism_Homo sapiens_hsa006501.77896096
24Pentose phosphate pathway_Homo sapiens_hsa000301.75015143
25Purine metabolism_Homo sapiens_hsa002301.70368749
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69952274
27RNA degradation_Homo sapiens_hsa030181.66484719
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63127609
29Nitrogen metabolism_Homo sapiens_hsa009101.61160941
30Antigen processing and presentation_Homo sapiens_hsa046121.50122751
31Huntingtons disease_Homo sapiens_hsa050161.50096932
32Selenocompound metabolism_Homo sapiens_hsa004501.37403437
33Non-homologous end-joining_Homo sapiens_hsa034501.32569702
34Legionellosis_Homo sapiens_hsa051341.30334896
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29073621
36Regulation of autophagy_Homo sapiens_hsa041401.24175239
37mRNA surveillance pathway_Homo sapiens_hsa030151.21480955
38* Oocyte meiosis_Homo sapiens_hsa041141.18609822
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17702579
40p53 signaling pathway_Homo sapiens_hsa041151.15161098
41Pyruvate metabolism_Homo sapiens_hsa006201.13714568
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11826799
43Epstein-Barr virus infection_Homo sapiens_hsa051691.11007133
44Collecting duct acid secretion_Homo sapiens_hsa049661.10207411
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09512084
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06005928
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03489266
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02549157
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.02494870
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01464001
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01012920
52Olfactory transduction_Homo sapiens_hsa047400.99050833
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.98602649
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97758026
55Retinol metabolism_Homo sapiens_hsa008300.97730228
56Herpes simplex infection_Homo sapiens_hsa051680.91812722
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91344288
58Caffeine metabolism_Homo sapiens_hsa002320.89814290
59Oxidative phosphorylation_Homo sapiens_hsa001900.88246965
60Taste transduction_Homo sapiens_hsa047420.85735885
61N-Glycan biosynthesis_Homo sapiens_hsa005100.85648025
62Type I diabetes mellitus_Homo sapiens_hsa049400.83581191
63Peroxisome_Homo sapiens_hsa041460.83113047
64Fatty acid elongation_Homo sapiens_hsa000620.81872409
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80878889
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80549802
67One carbon pool by folate_Homo sapiens_hsa006700.79931860
68Tryptophan metabolism_Homo sapiens_hsa003800.78307085
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78258160
70Chemical carcinogenesis_Homo sapiens_hsa052040.77502454
71beta-Alanine metabolism_Homo sapiens_hsa004100.75523101
72Rheumatoid arthritis_Homo sapiens_hsa053230.71351488
73ABC transporters_Homo sapiens_hsa020100.71032963
74Ether lipid metabolism_Homo sapiens_hsa005650.70939969
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.70340866
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69325090
77Dorso-ventral axis formation_Homo sapiens_hsa043200.69272966
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68070834
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65887048
80Fructose and mannose metabolism_Homo sapiens_hsa000510.65282821
81Glucagon signaling pathway_Homo sapiens_hsa049220.65189117
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65185639
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63672431
84Vibrio cholerae infection_Homo sapiens_hsa051100.60916145
85Primary immunodeficiency_Homo sapiens_hsa053400.56886368
86Measles_Homo sapiens_hsa051620.56871176
87Parkinsons disease_Homo sapiens_hsa050120.56182876
88Allograft rejection_Homo sapiens_hsa053300.51829717
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51662250
90Graft-versus-host disease_Homo sapiens_hsa053320.51517089
91Lysine degradation_Homo sapiens_hsa003100.51123138
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.50577413
93Linoleic acid metabolism_Homo sapiens_hsa005910.50464874
94Carbon metabolism_Homo sapiens_hsa012000.49935136
95Hematopoietic cell lineage_Homo sapiens_hsa046400.49232229
96Metabolic pathways_Homo sapiens_hsa011000.49227926
97Nicotine addiction_Homo sapiens_hsa050330.47437589
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.47345721
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47163788
100Fatty acid degradation_Homo sapiens_hsa000710.46896059
101Asthma_Homo sapiens_hsa053100.46363362
102Viral carcinogenesis_Homo sapiens_hsa052030.44984017
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44028690
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43286960
105TGF-beta signaling pathway_Homo sapiens_hsa043500.42850940
106Systemic lupus erythematosus_Homo sapiens_hsa053220.42324838
107Synaptic vesicle cycle_Homo sapiens_hsa047210.42078497
108Circadian rhythm_Homo sapiens_hsa047100.42018707
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40062304
110Amphetamine addiction_Homo sapiens_hsa050310.39614917
111Influenza A_Homo sapiens_hsa051640.38799554
112Mineral absorption_Homo sapiens_hsa049780.38738677
113Phagosome_Homo sapiens_hsa041450.38628344
114Fatty acid metabolism_Homo sapiens_hsa012120.38582396
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.38259664
116* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36222368
117Steroid biosynthesis_Homo sapiens_hsa001000.34067664
118HTLV-I infection_Homo sapiens_hsa051660.33369921
119Biosynthesis of amino acids_Homo sapiens_hsa012300.32681364
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32610244
121Hedgehog signaling pathway_Homo sapiens_hsa043400.32600704
122Glutathione metabolism_Homo sapiens_hsa004800.31883813
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31780894
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29986016
125Arachidonic acid metabolism_Homo sapiens_hsa005900.29289786
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28386452
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27847614
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26894510
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.26486924
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26235330
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25826062
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25810804
133Sphingolipid metabolism_Homo sapiens_hsa006000.25740502
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.25412291
135Propanoate metabolism_Homo sapiens_hsa006400.25190272
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24587437
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23955286
138Salivary secretion_Homo sapiens_hsa049700.23310095
139Renin-angiotensin system_Homo sapiens_hsa046140.22422948
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21723955
141Calcium signaling pathway_Homo sapiens_hsa040200.21552201
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.20780057
143Vitamin digestion and absorption_Homo sapiens_hsa049770.19670179
144Alzheimers disease_Homo sapiens_hsa050100.19507276
145Glycerolipid metabolism_Homo sapiens_hsa005610.16184997

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