SPDYE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located at chromosome 7p13 which is close to the Williams Beuren syndrome chromosome region 7q11.23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.13373182
2sperm motility (GO:0030317)6.48861354
3acrosome reaction (GO:0007340)6.34642100
4establishment of protein localization to Golgi (GO:0072600)5.22629582
5multicellular organism reproduction (GO:0032504)4.99291968
6cellular ketone body metabolic process (GO:0046950)4.94401486
7protein targeting to Golgi (GO:0000042)4.91633696
8fusion of sperm to egg plasma membrane (GO:0007342)4.89009756
9spermatid development (GO:0007286)4.81048904
10protein polyglutamylation (GO:0018095)4.78261162
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.70088613
12microtubule depolymerization (GO:0007019)4.34688495
13ketone body metabolic process (GO:1902224)4.33805014
14single strand break repair (GO:0000012)4.27529617
15regulation of cilium movement (GO:0003352)4.19865908
16phosphatidylethanolamine biosynthetic process (GO:0006646)4.12580881
17protein localization to Golgi apparatus (GO:0034067)4.07885398
18reproduction (GO:0000003)4.01761495
19microtubule severing (GO:0051013)3.96146682
20sperm-egg recognition (GO:0035036)3.92371373
21rRNA methylation (GO:0031167)3.86073560
22phosphatidylethanolamine metabolic process (GO:0046337)3.85105805
23spermatid nucleus differentiation (GO:0007289)3.74146638
24seminiferous tubule development (GO:0072520)3.72156352
25coenzyme catabolic process (GO:0009109)3.71691660
26plasma membrane fusion (GO:0045026)3.68951569
27cell wall macromolecule catabolic process (GO:0016998)3.68341595
28rRNA catabolic process (GO:0016075)3.59136415
29sperm capacitation (GO:0048240)3.48888322
30DNA deamination (GO:0045006)3.48457493
31calcium ion-dependent exocytosis (GO:0017156)3.46518115
32cell-cell recognition (GO:0009988)3.44780990
33centriole replication (GO:0007099)3.41647246
34microtubule polymerization or depolymerization (GO:0031109)3.38213534
35motile cilium assembly (GO:0044458)3.36854583
36cell wall macromolecule metabolic process (GO:0044036)3.34805360
37male meiosis (GO:0007140)3.32101258
38cilium or flagellum-dependent cell motility (GO:0001539)3.31960445
39rRNA modification (GO:0000154)3.31112493
40DNA packaging (GO:0006323)3.28889053
41positive regulation of granulocyte differentiation (GO:0030854)3.28007662
42regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.23972583
43positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.23972583
44single fertilization (GO:0007338)3.17736399
45chromosome condensation (GO:0030261)3.10293342
46regulation of Rab GTPase activity (GO:0032313)3.09798472
47positive regulation of Rab GTPase activity (GO:0032851)3.09798472
48epithelial cilium movement (GO:0003351)3.09616041
49spermatogenesis (GO:0007283)3.07933799
50positive regulation of mRNA catabolic process (GO:0061014)3.07753332
51male gamete generation (GO:0048232)3.07349713
52axonemal dynein complex assembly (GO:0070286)2.97782405
53NAD biosynthetic process (GO:0009435)2.96691001
54protein localization to cilium (GO:0061512)2.93452165
55fucose catabolic process (GO:0019317)2.91978727
56L-fucose metabolic process (GO:0042354)2.91978727
57L-fucose catabolic process (GO:0042355)2.91978727
58centriole assembly (GO:0098534)2.89228592
59chromatin silencing (GO:0006342)2.88832101
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88439923
61binding of sperm to zona pellucida (GO:0007339)2.83541044
62gamete generation (GO:0007276)2.80796551
63opioid receptor signaling pathway (GO:0038003)2.80083620
64cilium organization (GO:0044782)2.79214804
65positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74880093
66regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74880093
67cilium movement (GO:0003341)2.71882107
68negative regulation of Rho protein signal transduction (GO:0035024)2.69165805
69regulation of mRNA catabolic process (GO:0061013)2.69028630
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67594117
71cilium assembly (GO:0042384)2.65847921
72detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.65684503
73regulation of microtubule-based movement (GO:0060632)2.65217268
74nonmotile primary cilium assembly (GO:0035058)2.64225350
75axoneme assembly (GO:0035082)2.63959228
76histone mRNA catabolic process (GO:0071044)2.63771086
77purinergic nucleotide receptor signaling pathway (GO:0035590)2.63609245
78nephron tubule morphogenesis (GO:0072078)2.62947773
79nephron epithelium morphogenesis (GO:0072088)2.62947773
80photoreceptor cell maintenance (GO:0045494)2.62769671
81regulation of telomere maintenance (GO:0032204)2.59873435
82germ cell development (GO:0007281)2.59806843
83intra-Golgi vesicle-mediated transport (GO:0006891)2.59712085
84RNA destabilization (GO:0050779)2.59054378
85regulation of gamma-delta T cell differentiation (GO:0045586)2.56244562
86organic cation transport (GO:0015695)2.54797133
87DNA double-strand break processing (GO:0000729)2.54260776
88fertilization (GO:0009566)2.52075843
89positive regulation of defense response to virus by host (GO:0002230)2.50799195
90piRNA metabolic process (GO:0034587)2.50464944
91detection of light stimulus involved in sensory perception (GO:0050962)2.49620074
92detection of light stimulus involved in visual perception (GO:0050908)2.49620074
93protein K63-linked deubiquitination (GO:0070536)2.49595991
94negative regulation of gene expression, epigenetic (GO:0045814)2.49203470
95mast cell activation involved in immune response (GO:0002279)2.49136557
96mast cell degranulation (GO:0043303)2.49136557
97double-strand break repair via homologous recombination (GO:0000724)2.48896874
98negative regulation of mast cell activation (GO:0033004)2.47437152
99recombinational repair (GO:0000725)2.46913903
100urinary tract smooth muscle contraction (GO:0014848)2.46317339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.04685642
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.99009289
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.96320710
4EZH2_22144423_ChIP-Seq_EOC_Human2.89761091
5VDR_22108803_ChIP-Seq_LS180_Human2.35597213
6GBX2_23144817_ChIP-Seq_PC3_Human2.27658828
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18052667
8ER_23166858_ChIP-Seq_MCF-7_Human2.15521951
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15230252
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14605747
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14494148
12IGF1R_20145208_ChIP-Seq_DFB_Human2.09223736
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05609919
14CBP_20019798_ChIP-Seq_JUKART_Human2.04539412
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.04539412
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01461871
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95284200
18* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.91582586
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90447238
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.86874323
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84693473
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84693473
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84076162
24DROSHA_22980978_ChIP-Seq_HELA_Human1.80077950
25RUNX_20019798_ChIP-Seq_JUKART_Human1.79665952
26AR_21572438_ChIP-Seq_LNCaP_Human1.72360093
27ERA_21632823_ChIP-Seq_H3396_Human1.70803240
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69758599
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61588300
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59394913
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54917470
32STAT3_23295773_ChIP-Seq_U87_Human1.51152003
33FUS_26573619_Chip-Seq_HEK293_Human1.51104113
34RAC3_21632823_ChIP-Seq_H3396_Human1.43590702
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42183893
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41409731
37P300_19829295_ChIP-Seq_ESCs_Human1.40486940
38NANOG_20526341_ChIP-Seq_ESCs_Human1.39228947
39MYB_26560356_Chip-Seq_TH2_Human1.33786134
40GATA3_27048872_Chip-Seq_THYMUS_Human1.32475120
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32367718
42TCF4_23295773_ChIP-Seq_U87_Human1.30692501
43* OCT4_20526341_ChIP-Seq_ESCs_Human1.30414228
44GATA3_26560356_Chip-Seq_TH2_Human1.29592358
45SMAD4_21799915_ChIP-Seq_A2780_Human1.29181433
46AR_25329375_ChIP-Seq_VCAP_Human1.27424961
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26845952
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26049186
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.25713963
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25659990
51SCL_19346495_ChIP-Seq_HPC-7_Human1.25099418
52TAF2_19829295_ChIP-Seq_ESCs_Human1.23674419
53* MYC_19829295_ChIP-Seq_ESCs_Human1.23356508
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22528334
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.21565318
56SMRT_27268052_Chip-Seq_Bcells_Human1.21402988
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21092719
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19770107
59NANOG_19829295_ChIP-Seq_ESCs_Human1.17247158
60SOX2_19829295_ChIP-Seq_ESCs_Human1.17247158
61TP53_22573176_ChIP-Seq_HFKS_Human1.17216143
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16465798
63BCL6_27268052_Chip-Seq_Bcells_Human1.14494654
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.14318443
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14255677
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13724285
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.13624345
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13465494
69P300_27268052_Chip-Seq_Bcells_Human1.12794307
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12393143
71BCAT_22108803_ChIP-Seq_LS180_Human1.11872360
72RUNX2_22187159_ChIP-Seq_PCA_Human1.11698745
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11269987
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10883181
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10847954
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.10780902
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10515897
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10005921
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09701463
80CIITA_25753668_ChIP-Seq_RAJI_Human1.08198318
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07575295
82NCOR_22424771_ChIP-Seq_293T_Human1.06613314
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.05031307
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04673560
85* E2F1_20622854_ChIP-Seq_HELA_Human1.04392870
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04243538
87IRF1_19129219_ChIP-ChIP_H3396_Human1.02887040
88PHF8_20622854_ChIP-Seq_HELA_Human1.02295433
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01809039
90HOXB7_26014856_ChIP-Seq_BT474_Human1.01388318
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00813061
92ETV1_20927104_ChIP-Seq_GIST48_Human1.00125290
93* TCF4_22108803_ChIP-Seq_LS180_Human0.99865012
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.99418736
95TAF15_26573619_Chip-Seq_HEK293_Human0.98956442
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98751729
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97278176
98EWS_26573619_Chip-Seq_HEK293_Human0.96284289
99E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95511528
100* OCT1_27270436_Chip-Seq_PROSTATE_Human0.95223147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.76591859
2MP0000569_abnormal_digit_pigmentation3.58171939
3MP0003646_muscle_fatigue2.68220509
4MP0003698_abnormal_male_reproductive2.52248906
5MP0001984_abnormal_olfaction2.40479775
6MP0001929_abnormal_gametogenesis2.25354321
7MP0002102_abnormal_ear_morphology2.21779105
8MP0001501_abnormal_sleep_pattern2.14424123
9MP0005670_abnormal_white_adipose2.11196785
10MP0002132_abnormal_respiratory_system2.05970467
11MP0008877_abnormal_DNA_methylation1.90862421
12MP0005671_abnormal_response_to1.89915241
13MP0005551_abnormal_eye_electrophysiolog1.87100997
14MP0008058_abnormal_DNA_repair1.65276120
15MP0001968_abnormal_touch/_nociception1.64221520
16MP0003763_abnormal_thymus_physiology1.63025918
17MP0002735_abnormal_chemical_nociception1.55246635
18MP0001986_abnormal_taste_sensitivity1.51988537
19MP0005075_abnormal_melanosome_morpholog1.50978515
20MP0001835_abnormal_antigen_presentation1.48554151
21MP0005646_abnormal_pituitary_gland1.47856915
22MP0002653_abnormal_ependyma_morphology1.46471397
23MP0001800_abnormal_humoral_immune1.40378725
24MP0005645_abnormal_hypothalamus_physiol1.39250095
25MP0008995_early_reproductive_senescence1.37957162
26MP0003172_abnormal_lysosome_physiology1.36522178
27MP0003718_maternal_effect1.36448623
28MP0004043_abnormal_pH_regulation1.36220368
29MP0005310_abnormal_salivary_gland1.36122377
30MP0005253_abnormal_eye_physiology1.32826640
31MP0000015_abnormal_ear_pigmentation1.30778722
32MP0004142_abnormal_muscle_tone1.29401111
33MP0000372_irregular_coat_pigmentation1.19002948
34MP0009115_abnormal_fat_cell1.18069540
35MP0009046_muscle_twitch1.17975623
36MP0008961_abnormal_basal_metabolism1.16746331
37MP0003045_fibrosis1.14463099
38MP0002210_abnormal_sex_determination1.13860307
39MP0002161_abnormal_fertility/fecundity1.13298617
40MP0001486_abnormal_startle_reflex1.12531117
41MP0009697_abnormal_copulation1.11899581
42MP0002723_abnormal_immune_serum1.10082851
43MP0000465_gastrointestinal_hemorrhage1.09150096
44MP0003787_abnormal_imprinting1.07720078
45MP0003878_abnormal_ear_physiology1.07334925
46MP0005377_hearing/vestibular/ear_phenot1.07334925
47MP0002822_catalepsy1.06789297
48MP0002398_abnormal_bone_marrow1.06486937
49MP0002733_abnormal_thermal_nociception1.05545380
50MP0001765_abnormal_ion_homeostasis1.04306527
51MP0000703_abnormal_thymus_morphology1.03556630
52MP0005174_abnormal_tail_pigmentation1.03530690
53MP0008872_abnormal_physiological_respon1.00758001
54MP0002557_abnormal_social/conspecific_i0.99859382
55MP0000653_abnormal_sex_gland0.98256836
56MP0002928_abnormal_bile_duct0.97203607
57MP0002420_abnormal_adaptive_immunity0.97159184
58MP0002736_abnormal_nociception_after0.96744932
59MP0002272_abnormal_nervous_system0.96372329
60MP0001145_abnormal_male_reproductive0.94735917
61MP0002067_abnormal_sensory_capabilities0.94716747
62MP0001819_abnormal_immune_cell0.94142873
63MP0005423_abnormal_somatic_nervous0.93932009
64MP0000427_abnormal_hair_cycle0.92310399
65MP0005397_hematopoietic_system_phenotyp0.91614756
66MP0001545_abnormal_hematopoietic_system0.91614756
67MP0001270_distended_abdomen0.90540724
68MP0000716_abnormal_immune_system0.90520191
69MP0009785_altered_susceptibility_to0.90410557
70MP0002572_abnormal_emotion/affect_behav0.89798831
71MP0002452_abnormal_antigen_presenting0.89611438
72MP0003866_abnormal_defecation0.89559770
73MP0001529_abnormal_vocalization0.88781511
74MP0009278_abnormal_bone_marrow0.88290038
75MP0006072_abnormal_retinal_apoptosis0.88194827
76MP0006276_abnormal_autonomic_nervous0.87396524
77MP0008057_abnormal_DNA_replication0.87056046
78MP0010094_abnormal_chromosome_stability0.86843970
79MP0003786_premature_aging0.86779995
80MP0009745_abnormal_behavioral_response0.86481856
81MP0002722_abnormal_immune_system0.83707502
82MP0000230_abnormal_systemic_arterial0.82294342
83MP0005394_taste/olfaction_phenotype0.81746059
84MP0005499_abnormal_olfactory_system0.81746059
85MP0001764_abnormal_homeostasis0.81311776
86MP0009764_decreased_sensitivity_to0.81120620
87MP0005266_abnormal_metabolism0.80892603
88MP0001963_abnormal_hearing_physiology0.80419837
89MP0000689_abnormal_spleen_morphology0.80317453
90MP0005000_abnormal_immune_tolerance0.80055681
91MP0002234_abnormal_pharynx_morphology0.79797405
92MP0001970_abnormal_pain_threshold0.78984607
93MP0004084_abnormal_cardiac_muscle0.78161732
94MP0002138_abnormal_hepatobiliary_system0.76606920
95MP0004924_abnormal_behavior0.75760877
96MP0005386_behavior/neurological_phenoty0.75760877
97MP0004036_abnormal_muscle_relaxation0.75523254
98MP0005395_other_phenotype0.74072124
99MP0002229_neurodegeneration0.73852986
100MP0002970_abnormal_white_adipose0.73775796

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.89444781
2Severe visual impairment (HP:0001141)4.15831320
3Attenuation of retinal blood vessels (HP:0007843)4.11876336
4Genetic anticipation (HP:0003743)3.89190988
5Nephronophthisis (HP:0000090)3.72988622
6Pancreatic cysts (HP:0001737)3.30595559
7Abnormality of the renal medulla (HP:0100957)3.30470363
8Progressive cerebellar ataxia (HP:0002073)3.28357355
9Abnormal rod and cone electroretinograms (HP:0008323)3.14477035
10Abnormality of the renal cortex (HP:0011035)3.11179036
11Impulsivity (HP:0100710)3.00827136
12Bony spicule pigmentary retinopathy (HP:0007737)3.00713983
13Pancreatic fibrosis (HP:0100732)2.98871292
14Tubulointerstitial nephritis (HP:0001970)2.97477662
15Severe combined immunodeficiency (HP:0004430)2.89906363
16Abnormality of midbrain morphology (HP:0002418)2.82792057
17Molar tooth sign on MRI (HP:0002419)2.82792057
18Medial flaring of the eyebrow (HP:0010747)2.78777511
19Abnormal drinking behavior (HP:0030082)2.74106876
20Polydipsia (HP:0001959)2.74106876
21Thyroiditis (HP:0100646)2.60154590
22Gait imbalance (HP:0002141)2.59729975
23True hermaphroditism (HP:0010459)2.54958550
24Abnormality of DNA repair (HP:0003254)2.52545315
25Cystic liver disease (HP:0006706)2.50546667
26Poor coordination (HP:0002370)2.48454094
27Abnormality of eosinophils (HP:0001879)2.48449117
28Tubular atrophy (HP:0000092)2.42575159
29Protruding tongue (HP:0010808)2.41987397
30Failure to thrive in infancy (HP:0001531)2.40189748
31Congenital primary aphakia (HP:0007707)2.39133293
32Decreased central vision (HP:0007663)2.38405140
33Enlarged epiphyses (HP:0010580)2.37267583
34Cerebellar dysplasia (HP:0007033)2.35354536
35Nephrogenic diabetes insipidus (HP:0009806)2.35316977
36Gaze-evoked nystagmus (HP:0000640)2.35171203
37Hypoplasia of the thymus (HP:0000778)2.33458950
38Eosinophilia (HP:0001880)2.31814927
39Abnormality of B cell number (HP:0010975)2.31049404
40Granulocytopenia (HP:0001913)2.30246778
41Abnormality of the columella (HP:0009929)2.28886848
42Congenital stationary night blindness (HP:0007642)2.28209960
43Hyperventilation (HP:0002883)2.27259839
44Clumsiness (HP:0002312)2.22210903
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.21577026
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.20903405
47Absent/shortened dynein arms (HP:0200106)2.20903405
48Tubulointerstitial abnormality (HP:0001969)2.20263448
49Polyuria (HP:0000103)2.19101851
50Bulbous nose (HP:0000414)2.17337576
51Truncal obesity (HP:0001956)2.14259289
52Hypoproteinemia (HP:0003075)2.11469951
53Ketosis (HP:0001946)2.11371619
54Congenital hepatic fibrosis (HP:0002612)2.09752644
55Clubbing of toes (HP:0100760)2.08882595
56Bile duct proliferation (HP:0001408)2.08235110
57Abnormal biliary tract physiology (HP:0012439)2.08235110
58Hyperkalemia (HP:0002153)2.07287042
59Renal cortical cysts (HP:0000803)2.06470592
60Retinal dysplasia (HP:0007973)2.05007374
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04595405
62Autoimmune thrombocytopenia (HP:0001973)2.02880860
63Panhypogammaglobulinemia (HP:0003139)2.01211627
64B lymphocytopenia (HP:0010976)1.99997237
65Increased corneal curvature (HP:0100692)1.99199270
66Keratoconus (HP:0000563)1.99199270
67Combined immunodeficiency (HP:0005387)1.98992730
68Cone-rod dystrophy (HP:0000548)1.98363722
69Chromsome breakage (HP:0040012)1.93672983
70Autoimmune hemolytic anemia (HP:0001890)1.93346716
71Volvulus (HP:0002580)1.92789445
72Stomatitis (HP:0010280)1.92507810
73Abnormal urine output (HP:0012590)1.92400383
74Abnormality of T cells (HP:0002843)1.92137978
75Hypoplastic ischia (HP:0003175)1.92085434
76Type II lissencephaly (HP:0007260)1.90261155
77T lymphocytopenia (HP:0005403)1.88490567
78Portal hypertension (HP:0001409)1.88395662
79IgG deficiency (HP:0004315)1.87061523
80Abnormality of the fingertips (HP:0001211)1.86486305
81Progressive inability to walk (HP:0002505)1.86224715
82Stage 5 chronic kidney disease (HP:0003774)1.84813388
83Abnormality of T cell number (HP:0011839)1.83178138
84Macular degeneration (HP:0000608)1.82956753
85Large for gestational age (HP:0001520)1.82732270
86Type II diabetes mellitus (HP:0005978)1.82684415
87Abnormality of lateral ventricle (HP:0030047)1.82320402
88Optic neuritis (HP:0100653)1.82174408
89Retrobulbar optic neuritis (HP:0100654)1.82174408
90Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80939366
91Inability to walk (HP:0002540)1.80498997
92Abnormal ciliary motility (HP:0012262)1.79692192
93Abnormality of the ileum (HP:0001549)1.78984416
94Abnormality of macular pigmentation (HP:0008002)1.78874875
95Thyroid-stimulating hormone excess (HP:0002925)1.78199689
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77154192
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75707867
98Postaxial foot polydactyly (HP:0001830)1.75360465
99Genital tract atresia (HP:0001827)1.74950236
100Astigmatism (HP:0000483)1.74771564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.63051731
2FRK3.84385024
3PINK12.81263169
4CDK122.73834834
5PLK42.65845160
6TAOK32.57695273
7INSRR2.48008648
8TXK2.08194525
9MAPK131.91081495
10BLK1.88629259
11TNK21.75307710
12WNK41.74520782
13BCKDK1.74138915
14BRD41.61090133
15MUSK1.60603134
16MAP4K11.59729277
17STK381.54673741
18MAP2K61.50470084
19TNIK1.46369783
20ZAK1.39930775
21BMPR1B1.32419513
22CAMK1G1.29657267
23SYK1.28803197
24ITK1.26822377
25MARK31.24684412
26DDR21.22696927
27NUAK11.22417810
28KIT1.21939445
29AKT31.20350738
30FES1.20087301
31PIK3CG1.19035493
32NME11.17909860
33ACVR1B1.13087393
34ADRBK21.06727743
35NLK1.01440538
36OBSCN1.00741372
37PTK2B0.99128064
38MARK10.98015665
39TEC0.97400760
40CAMK1D0.97166974
41PRKCH0.95249257
42TLK10.94768509
43CDK30.92832465
44MST1R0.92700617
45NEK20.92236914
46MAPK110.90269525
47BTK0.87434525
48WNK30.85236188
49GRK10.82466640
50PIK3CA0.81320958
51WNK10.81304921
52PDK10.74539371
53KDR0.74392630
54MAPKAPK30.73022587
55MAPK150.72435162
56CAMK10.72085154
57ATR0.71997338
58ZAP700.71469560
59CAMK40.71361227
60RPS6KA50.71275178
61EPHA30.71217988
62CSNK1A1L0.69915971
63OXSR10.68232660
64IKBKB0.64228720
65TESK10.62924685
66FLT30.62823273
67CASK0.61118340
68PRKAA10.60301250
69LCK0.57989674
70RPS6KA40.57748640
71PHKG10.57056629
72PHKG20.57056629
73PRKCQ0.53991544
74SIK20.53223759
75LYN0.53005774
76DYRK20.50560963
77MAP2K70.49313855
78MAPK10.49143114
79GRK60.48821444
80PRKCE0.48262735
81EIF2AK30.48237197
82PLK20.47639161
83PRKAA20.46394369
84JAK10.46073550
85RPS6KA60.45684231
86RPS6KA10.43489077
87CAMKK20.42550965
88SGK20.42373838
89MATK0.41898548
90CHUK0.41690336
91ATM0.41619990
92TRPM70.41528132
93GSK3B0.40671720
94STK390.39976917
95MAP3K40.39550100
96PRKG10.38484462
97JAK30.38127003
98VRK10.37528530
99SGK4940.37140054
100SGK2230.37140054

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.33437829
2Butanoate metabolism_Homo sapiens_hsa006502.96700094
3Primary immunodeficiency_Homo sapiens_hsa053402.90514919
4Olfactory transduction_Homo sapiens_hsa047402.77969336
5Fanconi anemia pathway_Homo sapiens_hsa034602.72387991
6Phototransduction_Homo sapiens_hsa047442.52914095
7Graft-versus-host disease_Homo sapiens_hsa053322.27039747
8Fatty acid biosynthesis_Homo sapiens_hsa000612.18861773
9Homologous recombination_Homo sapiens_hsa034402.13533145
10Allograft rejection_Homo sapiens_hsa053302.00973099
11Autoimmune thyroid disease_Homo sapiens_hsa053201.99868738
12RNA polymerase_Homo sapiens_hsa030201.91692242
13Type I diabetes mellitus_Homo sapiens_hsa049401.89391328
14Taste transduction_Homo sapiens_hsa047421.83767335
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.77946847
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60066128
17Nitrogen metabolism_Homo sapiens_hsa009101.58183039
18ABC transporters_Homo sapiens_hsa020101.57368149
19Lysine degradation_Homo sapiens_hsa003101.57048075
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47312663
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45743403
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43612842
23Antigen processing and presentation_Homo sapiens_hsa046121.42835601
24Asthma_Homo sapiens_hsa053101.35902966
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35608905
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33217104
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30884860
28* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29231960
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25866622
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22422378
31Basal transcription factors_Homo sapiens_hsa030221.21743131
32Salivary secretion_Homo sapiens_hsa049701.20756878
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.15638941
34Base excision repair_Homo sapiens_hsa034101.13009655
35Circadian rhythm_Homo sapiens_hsa047101.12641720
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12103363
37Calcium signaling pathway_Homo sapiens_hsa040201.11300064
38Propanoate metabolism_Homo sapiens_hsa006401.10213165
39Linoleic acid metabolism_Homo sapiens_hsa005911.09683287
40Non-homologous end-joining_Homo sapiens_hsa034501.04821322
41Circadian entrainment_Homo sapiens_hsa047131.03683724
42Purine metabolism_Homo sapiens_hsa002301.02287178
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01997467
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01878715
45Hematopoietic cell lineage_Homo sapiens_hsa046401.01511058
46Regulation of autophagy_Homo sapiens_hsa041401.00357389
47Dorso-ventral axis formation_Homo sapiens_hsa043200.99978022
48Type II diabetes mellitus_Homo sapiens_hsa049300.99075517
49Peroxisome_Homo sapiens_hsa041460.96597149
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92112975
51RNA degradation_Homo sapiens_hsa030180.89796991
52* Oocyte meiosis_Homo sapiens_hsa041140.88583405
53Nicotine addiction_Homo sapiens_hsa050330.84815645
54Renin secretion_Homo sapiens_hsa049240.84770921
55Morphine addiction_Homo sapiens_hsa050320.81746772
56One carbon pool by folate_Homo sapiens_hsa006700.81156469
57Pyrimidine metabolism_Homo sapiens_hsa002400.80089618
58Glycerolipid metabolism_Homo sapiens_hsa005610.78440936
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.78326683
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.78095344
61Fatty acid metabolism_Homo sapiens_hsa012120.78027167
62Viral myocarditis_Homo sapiens_hsa054160.77620400
63Herpes simplex infection_Homo sapiens_hsa051680.76700833
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76502376
65Ether lipid metabolism_Homo sapiens_hsa005650.72827650
66Insulin secretion_Homo sapiens_hsa049110.70618901
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68609623
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67989908
69Oxytocin signaling pathway_Homo sapiens_hsa049210.64904017
70Glutamatergic synapse_Homo sapiens_hsa047240.63900233
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63140420
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.63120725
73T cell receptor signaling pathway_Homo sapiens_hsa046600.60361444
74DNA replication_Homo sapiens_hsa030300.60113996
75Tryptophan metabolism_Homo sapiens_hsa003800.58627673
76Selenocompound metabolism_Homo sapiens_hsa004500.58533146
77Nucleotide excision repair_Homo sapiens_hsa034200.57644572
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57371343
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55338960
80Platelet activation_Homo sapiens_hsa046110.52840568
81Mismatch repair_Homo sapiens_hsa034300.51352890
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.50662256
83GABAergic synapse_Homo sapiens_hsa047270.48933466
84Caffeine metabolism_Homo sapiens_hsa002320.48353573
85RNA transport_Homo sapiens_hsa030130.46563057
86Gastric acid secretion_Homo sapiens_hsa049710.45227069
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44340389
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44024669
89cAMP signaling pathway_Homo sapiens_hsa040240.42124015
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41417466
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40652501
92Inositol phosphate metabolism_Homo sapiens_hsa005620.39722050
93Measles_Homo sapiens_hsa051620.39224848
94Influenza A_Homo sapiens_hsa051640.37628861
95mRNA surveillance pathway_Homo sapiens_hsa030150.37220623
96Chemical carcinogenesis_Homo sapiens_hsa052040.36200839
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32471868
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29844470
99Serotonergic synapse_Homo sapiens_hsa047260.29642663
100Cholinergic synapse_Homo sapiens_hsa047250.26519160

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