SPDYE10P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)8.75618651
2protein targeting to Golgi (GO:0000042)8.70358169
3retrograde transport, vesicle recycling within Golgi (GO:0000301)8.40163310
4sperm motility (GO:0030317)8.12072205
5acrosome reaction (GO:0007340)7.80430673
6response to pheromone (GO:0019236)7.61518607
7protein localization to Golgi apparatus (GO:0034067)6.81089669
8DNA packaging (GO:0006323)5.71989127
9sperm capacitation (GO:0048240)5.70294944
10chromosome condensation (GO:0030261)5.59102971
11protein polyglutamylation (GO:0018095)5.57614021
12spermatid development (GO:0007286)5.47704754
13fusion of sperm to egg plasma membrane (GO:0007342)5.39238687
14microtubule depolymerization (GO:0007019)5.31893273
15multicellular organism reproduction (GO:0032504)5.27827869
16single strand break repair (GO:0000012)5.26068363
17spermatid nucleus differentiation (GO:0007289)5.16874099
18microtubule severing (GO:0051013)5.16726193
19cellular ketone body metabolic process (GO:0046950)5.07925686
20cilium or flagellum-dependent cell motility (GO:0001539)4.79698072
21phosphatidylethanolamine biosynthetic process (GO:0006646)4.66232892
22rRNA methylation (GO:0031167)4.61197712
23reproduction (GO:0000003)4.54474487
24sperm-egg recognition (GO:0035036)4.51215435
25microtubule polymerization or depolymerization (GO:0031109)4.44037991
26ketone body metabolic process (GO:1902224)4.39159659
27regulation of ARF GTPase activity (GO:0032312)4.38452702
28phosphatidylethanolamine metabolic process (GO:0046337)4.37893049
29centriole replication (GO:0007099)4.36229896
30calcium ion-dependent exocytosis (GO:0017156)4.19661708
31axonemal dynein complex assembly (GO:0070286)4.11896564
32regulation of Rab GTPase activity (GO:0032313)4.02898064
33positive regulation of Rab GTPase activity (GO:0032851)4.02898064
34intra-Golgi vesicle-mediated transport (GO:0006891)4.01046930
35maintenance of gastrointestinal epithelium (GO:0030277)4.00193177
36cell wall macromolecule catabolic process (GO:0016998)3.98948055
37cell-cell recognition (GO:0009988)3.97397469
38spermatogenesis (GO:0007283)3.94552739
39male gamete generation (GO:0048232)3.93908844
40regulation of cilium movement (GO:0003352)3.93238835
41plasma membrane fusion (GO:0045026)3.85919674
42epithelial cilium movement (GO:0003351)3.82006565
43rRNA modification (GO:0000154)3.77079451
44chromatin silencing (GO:0006342)3.75149211
45nephron tubule morphogenesis (GO:0072078)3.66191598
46nephron epithelium morphogenesis (GO:0072088)3.66191598
47gamete generation (GO:0007276)3.62754327
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59715699
49negative regulation of inclusion body assembly (GO:0090084)3.59517907
50RNA destabilization (GO:0050779)3.55809777
51centriole assembly (GO:0098534)3.55089552
52motile cilium assembly (GO:0044458)3.53308272
53single fertilization (GO:0007338)3.51377463
54cell wall macromolecule metabolic process (GO:0044036)3.51150449
55microtubule nucleation (GO:0007020)3.50556675
56seminiferous tubule development (GO:0072520)3.46080968
57binding of sperm to zona pellucida (GO:0007339)3.38272951
58histone H3-K4 trimethylation (GO:0080182)3.36636124
59histone H3-K9 demethylation (GO:0033169)3.32456092
60cilium movement (GO:0003341)3.23234885
61sexual reproduction (GO:0019953)3.20483395
62germ cell development (GO:0007281)3.18783869
63nucleosome disassembly (GO:0006337)3.18357993
64protein-DNA complex disassembly (GO:0032986)3.18357993
65regulation of somitogenesis (GO:0014807)3.11196129
66negative regulation of gene expression, epigenetic (GO:0045814)3.09219623
67histone H3-K9 methylation (GO:0051567)3.09202063
68renal tubule morphogenesis (GO:0061333)3.01737907
69photoreceptor cell maintenance (GO:0045494)3.01567754
70axoneme assembly (GO:0035082)3.00806715
71cranial nerve morphogenesis (GO:0021602)3.00145634
72NAD biosynthetic process (GO:0009435)2.98809398
73negative regulation of Rho protein signal transduction (GO:0035024)2.95232663
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93561115
75regulation of microtubule-based movement (GO:0060632)2.92425798
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91886738
77histone mRNA catabolic process (GO:0071044)2.91477909
78regulation of transcription involved in cell fate commitment (GO:0060850)2.91221037
79peptidyl-lysine trimethylation (GO:0018023)2.89116488
80multicellular organismal reproductive process (GO:0048609)2.89053368
81positive regulation of granulocyte differentiation (GO:0030854)2.88967297
82regulation of ruffle assembly (GO:1900027)2.86999040
83cellular process involved in reproduction in multicellular organism (GO:0022412)2.85036815
84L-fucose catabolic process (GO:0042355)2.83601861
85fucose catabolic process (GO:0019317)2.83601861
86L-fucose metabolic process (GO:0042354)2.83601861
87regulation of telomere maintenance (GO:0032204)2.83034635
88regulation of establishment of cell polarity (GO:2000114)2.80836467
89fertilization (GO:0009566)2.77893809
90nucleus organization (GO:0006997)2.74476550
91protein K48-linked deubiquitination (GO:0071108)2.73328404
92regulation of establishment or maintenance of cell polarity (GO:0032878)2.70662342
93inner ear receptor cell differentiation (GO:0060113)2.70622437
94epithelial structure maintenance (GO:0010669)2.69948681
95coenzyme catabolic process (GO:0009109)2.69907258
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67631790
97actin nucleation (GO:0045010)2.65398115
98positive regulation of action potential (GO:0045760)2.64752514
99regulation of glucokinase activity (GO:0033131)2.63402434
100regulation of hexokinase activity (GO:1903299)2.63402434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human2.72312813
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66959649
3EZH2_22144423_ChIP-Seq_EOC_Human2.61607610
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40705002
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33873144
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33832673
7ER_23166858_ChIP-Seq_MCF-7_Human2.31191291
8WDR5_24793694_ChIP-Seq_LNCAP_Human2.25776789
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10900302
10FUS_26573619_Chip-Seq_HEK293_Human2.09197247
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07880280
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01336292
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01336292
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00364258
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98235962
16VDR_22108803_ChIP-Seq_LS180_Human1.94883130
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.94799901
18CBP_20019798_ChIP-Seq_JUKART_Human1.94799901
19ZNF274_21170338_ChIP-Seq_K562_Hela1.88452686
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82680105
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82017931
22GBX2_23144817_ChIP-Seq_PC3_Human1.81021141
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.78195688
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77445161
25ERA_21632823_ChIP-Seq_H3396_Human1.75154775
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66159094
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.66153963
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58369620
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52309854
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.48485543
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46523580
32SCL_19346495_ChIP-Seq_HPC-7_Human1.45905426
33MYC_19829295_ChIP-Seq_ESCs_Human1.45124607
34TAF15_26573619_Chip-Seq_HEK293_Human1.44868274
35NANOG_20526341_ChIP-Seq_ESCs_Human1.42563945
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42447688
37RAC3_21632823_ChIP-Seq_H3396_Human1.42376210
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.41355762
39STAT3_23295773_ChIP-Seq_U87_Human1.41054540
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38763422
41AR_25329375_ChIP-Seq_VCAP_Human1.38620271
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36147761
43BCL6_27268052_Chip-Seq_Bcells_Human1.35255145
44OCT4_20526341_ChIP-Seq_ESCs_Human1.33399403
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32045132
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31088555
47E2F1_20622854_ChIP-Seq_HELA_Human1.30526126
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27454527
49RUNX_20019798_ChIP-Seq_JUKART_Human1.26621028
50P300_19829295_ChIP-Seq_ESCs_Human1.26397133
51TCF4_23295773_ChIP-Seq_U87_Human1.24902215
52P300_27268052_Chip-Seq_Bcells_Human1.24627533
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23606035
54TAF2_19829295_ChIP-Seq_ESCs_Human1.23096103
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.21400018
56PHF8_20622854_ChIP-Seq_HELA_Human1.21276793
57SMAD4_21799915_ChIP-Seq_A2780_Human1.19060146
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18859227
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18364483
60AR_21572438_ChIP-Seq_LNCaP_Human1.18028932
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17611789
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.16317055
63E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15450678
64RUNX2_22187159_ChIP-Seq_PCA_Human1.15412903
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.14843687
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14840069
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.12160832
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11016953
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09548062
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09380920
71SMRT_27268052_Chip-Seq_Bcells_Human1.08929842
72CTCF_20526341_ChIP-Seq_ESCs_Human1.08703681
73P53_21459846_ChIP-Seq_SAOS-2_Human1.08690312
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08369014
75CEBPB_22108803_ChIP-Seq_LS180_Human1.07434044
76SMC4_20622854_ChIP-Seq_HELA_Human1.06448596
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06414605
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.05772667
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04454252
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.03284153
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03222882
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02352691
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.02352691
84P68_20966046_ChIP-Seq_HELA_Human1.02054637
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02021963
86TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02004178
87TBL1_22424771_ChIP-Seq_293T_Human1.01471704
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.01016063
89ETV1_20927104_ChIP-Seq_GIST48_Human1.00742821
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00464020
91BCOR_27268052_Chip-Seq_Bcells_Human1.00062587
92REST_21632747_ChIP-Seq_MESCs_Mouse0.99960056
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.99847940
94TP63_22573176_ChIP-Seq_HFKS_Human0.99602151
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99446392
96HOXB7_26014856_ChIP-Seq_BT474_Human0.98789931
97OCT4_19829295_ChIP-Seq_ESCs_Human0.98039255
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97369410
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97271714
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96878900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.72228103
2MP0003878_abnormal_ear_physiology3.22214082
3MP0005377_hearing/vestibular/ear_phenot3.22214082
4MP0003698_abnormal_male_reproductive3.08251628
5MP0005670_abnormal_white_adipose2.72799719
6MP0001485_abnormal_pinna_reflex2.68917667
7MP0000569_abnormal_digit_pigmentation2.59092120
8MP0001929_abnormal_gametogenesis2.58449632
9MP0008004_abnormal_stomach_pH2.32532175
10MP0000465_gastrointestinal_hemorrhage2.17122199
11MP0004742_abnormal_vestibular_system2.08979154
12MP0010386_abnormal_urinary_bladder2.01590814
13MP0004043_abnormal_pH_regulation1.98298800
14MP0008877_abnormal_DNA_methylation1.92457962
15MP0003787_abnormal_imprinting1.90400871
16MP0005310_abnormal_salivary_gland1.89829751
17MP0002822_catalepsy1.88345512
18MP0003646_muscle_fatigue1.86217484
19MP0002234_abnormal_pharynx_morphology1.75287891
20MP0003866_abnormal_defecation1.74909430
21MP0001348_abnormal_lacrimal_gland1.71843177
22MP0003879_abnormal_hair_cell1.70670602
23MP0005551_abnormal_eye_electrophysiolog1.65657166
24MP0005083_abnormal_biliary_tract1.56218942
25MP0002161_abnormal_fertility/fecundity1.52872718
26MP0001765_abnormal_ion_homeostasis1.51301287
27MP0003718_maternal_effect1.45690065
28MP0006292_abnormal_olfactory_placode1.45484955
29MP0002249_abnormal_larynx_morphology1.42430394
30MP0005645_abnormal_hypothalamus_physiol1.39490283
31MP0008961_abnormal_basal_metabolism1.35329995
32MP0001666_abnormal_nutrient_absorption1.34467487
33MP0001664_abnormal_digestion1.33436999
34MP0000026_abnormal_inner_ear1.33321315
35MP0001963_abnormal_hearing_physiology1.32260524
36MP0002229_neurodegeneration1.27109580
37MP0008995_early_reproductive_senescence1.26778303
38MP0002928_abnormal_bile_duct1.25925094
39MP0001986_abnormal_taste_sensitivity1.25240385
40MP0002210_abnormal_sex_determination1.23364068
41MP0002735_abnormal_chemical_nociception1.20737497
42MP0001486_abnormal_startle_reflex1.18684139
43MP0002067_abnormal_sensory_capabilities1.17066984
44MP0000470_abnormal_stomach_morphology1.15687937
45MP0003045_fibrosis1.13504573
46MP0000015_abnormal_ear_pigmentation1.11583558
47MP0001968_abnormal_touch/_nociception1.10878747
48MP0000566_synostosis1.10310806
49MP0009384_cardiac_valve_regurgitation1.02406307
50MP0002272_abnormal_nervous_system0.99365195
51MP0002132_abnormal_respiratory_system0.99105661
52MP0000653_abnormal_sex_gland0.98483714
53MP0000678_abnormal_parathyroid_gland0.98124337
54MP0005423_abnormal_somatic_nervous0.98071180
55MP0002127_abnormal_cardiovascular_syste0.98006716
56MP0001145_abnormal_male_reproductive0.95868806
57MP0003011_delayed_dark_adaptation0.95660039
58MP0002282_abnormal_trachea_morphology0.92818406
59MP0000427_abnormal_hair_cycle0.91163776
60MP0001501_abnormal_sleep_pattern0.90880174
61MP0002557_abnormal_social/conspecific_i0.90265297
62MP0002638_abnormal_pupillary_reflex0.89903110
63MP0005253_abnormal_eye_physiology0.88394406
64MP0005646_abnormal_pituitary_gland0.87105093
65MP0004145_abnormal_muscle_electrophysio0.86645524
66MP0005395_other_phenotype0.86499215
67MP0002653_abnormal_ependyma_morphology0.85272174
68MP0002138_abnormal_hepatobiliary_system0.84598161
69MP0009046_muscle_twitch0.83942548
70MP0001545_abnormal_hematopoietic_system0.83623648
71MP0005397_hematopoietic_system_phenotyp0.83623648
72MP0001270_distended_abdomen0.83561823
73MP0002166_altered_tumor_susceptibility0.82514048
74MP0010307_abnormal_tumor_latency0.81676161
75MP0005379_endocrine/exocrine_gland_phen0.77871034
76MP0001873_stomach_inflammation0.76924032
77MP0002095_abnormal_skin_pigmentation0.75853566
78MP0002572_abnormal_emotion/affect_behav0.75617397
79MP0003252_abnormal_bile_duct0.75352635
80MP0000538_abnormal_urinary_bladder0.73731957
81MP0001835_abnormal_antigen_presentation0.72789809
82MP0000371_diluted_coat_color0.70732309
83MP0000230_abnormal_systemic_arterial0.70670534
84MP0002752_abnormal_somatic_nervous0.70436075
85MP0003631_nervous_system_phenotype0.70414882
86MP0002733_abnormal_thermal_nociception0.69771128
87MP0009278_abnormal_bone_marrow0.69100994
88MP0005266_abnormal_metabolism0.69028351
89MP0003283_abnormal_digestive_organ0.68937399
90MP0009745_abnormal_behavioral_response0.67756256
91MP0005174_abnormal_tail_pigmentation0.66817953
92MP0008057_abnormal_DNA_replication0.66606464
93MP0000955_abnormal_spinal_cord0.65923383
94MP0003633_abnormal_nervous_system0.65472116
95MP0001663_abnormal_digestive_system0.63985487
96MP0005503_abnormal_tendon_morphology0.63573793
97MP0002168_other_aberrant_phenotype0.62193371
98MP0003635_abnormal_synaptic_transmissio0.61672471
99MP0004134_abnormal_chest_morphology0.59729817
100MP0005636_abnormal_mineral_homeostasis0.59335220

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.43931764
2Tubulointerstitial nephritis (HP:0001970)4.51074370
3Hypoplastic ischia (HP:0003175)4.05198765
4Attenuation of retinal blood vessels (HP:0007843)3.98475977
5Enlarged epiphyses (HP:0010580)3.98047419
6Hyperkalemia (HP:0002153)3.83291035
7Nephronophthisis (HP:0000090)3.79684821
8Bony spicule pigmentary retinopathy (HP:0007737)3.78624136
9Abnormality of the renal medulla (HP:0100957)3.46617260
10Abnormality of the aortic arch (HP:0012303)3.41122011
11Absent/shortened dynein arms (HP:0200106)3.38605552
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.38605552
13Chronic hepatic failure (HP:0100626)3.31893900
14Abnormality of the ischium (HP:0003174)3.25049241
15Genetic anticipation (HP:0003743)3.17874651
16Progressive cerebellar ataxia (HP:0002073)3.17504205
17Abnormality of DNA repair (HP:0003254)3.16490716
18Abnormal rod and cone electroretinograms (HP:0008323)3.13941806
19Impulsivity (HP:0100710)3.00883597
20Abnormality of the fingertips (HP:0001211)2.90692583
21Truncal obesity (HP:0001956)2.85474605
22Hypoplasia of the thymus (HP:0000778)2.83948397
23Abnormality of the parathyroid morphology (HP:0011766)2.80540823
24Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77082141
25Tubular atrophy (HP:0000092)2.63142160
26Abnormality of the renal cortex (HP:0011035)2.60607124
27Pancreatic cysts (HP:0001737)2.48522242
28Abnormal ciliary motility (HP:0012262)2.44190870
29Tubulointerstitial abnormality (HP:0001969)2.41479813
30Molar tooth sign on MRI (HP:0002419)2.40597144
31Abnormality of midbrain morphology (HP:0002418)2.40597144
32Abnormality of macular pigmentation (HP:0008002)2.39741030
33Abnormal respiratory epithelium morphology (HP:0012253)2.39656403
34Abnormal respiratory motile cilium morphology (HP:0005938)2.39656403
35Cystic liver disease (HP:0006706)2.39373205
36Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39186267
37Chromsome breakage (HP:0040012)2.38583236
38Pancreatic fibrosis (HP:0100732)2.35765719
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35749417
40Abnormality of chloride homeostasis (HP:0011422)2.33540631
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31927964
42Abnormality of the femoral head (HP:0003368)2.24217749
43Cerebellar dysplasia (HP:0007033)2.24139367
44Duplicated collecting system (HP:0000081)2.21299062
45Cone-rod dystrophy (HP:0000548)2.20112394
46Abnormality of the nasal septum (HP:0000419)2.19796945
47Bulbous nose (HP:0000414)2.19702618
48Clubbing of toes (HP:0100760)2.19327816
49Abnormality of the epiphysis of the femoral head (HP:0010574)2.16878150
50Abnormality of the renal collecting system (HP:0004742)2.13762570
51Hypoplastic iliac wings (HP:0002866)2.11212644
52Male infertility (HP:0003251)2.08576389
53Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.08382456
54Abnormality of femoral epiphyses (HP:0006499)2.08382456
55Increased corneal curvature (HP:0100692)2.05241483
56Keratoconus (HP:0000563)2.05241483
57Abnormality of potassium homeostasis (HP:0011042)2.02792692
58Congenital hepatic fibrosis (HP:0002612)2.01586149
59Abnormality of the pubic bones (HP:0003172)2.00673352
60Palpebral edema (HP:0100540)1.99423554
61True hermaphroditism (HP:0010459)1.98913301
62Stage 5 chronic kidney disease (HP:0003774)1.97480433
63Bell-shaped thorax (HP:0001591)1.97224809
64Hypophosphatemic rickets (HP:0004912)1.96510126
65Ectopic kidney (HP:0000086)1.96496258
66Aplasia/Hypoplasia of the uvula (HP:0010293)1.94365961
67Abnormal drinking behavior (HP:0030082)1.93896418
68Polydipsia (HP:0001959)1.93896418
69Long eyelashes (HP:0000527)1.92902088
70Gaze-evoked nystagmus (HP:0000640)1.92587797
71Prominent nose (HP:0000448)1.92548845
72Abnormal respiratory motile cilium physiology (HP:0012261)1.90637762
73Renal Fanconi syndrome (HP:0001994)1.89351719
74Progressive sensorineural hearing impairment (HP:0000408)1.88420733
75Abnormality of the columella (HP:0009929)1.87335822
76Pendular nystagmus (HP:0012043)1.82492299
77Macular degeneration (HP:0000608)1.82118619
78Congenital sensorineural hearing impairment (HP:0008527)1.81027921
79Decreased central vision (HP:0007663)1.80256907
80Sloping forehead (HP:0000340)1.79801246
81Abnormality of lateral ventricle (HP:0030047)1.79339210
82Tented upper lip vermilion (HP:0010804)1.78763958
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78331361
84Abnormality of renal resorption (HP:0011038)1.78309382
85Abnormality of incisor morphology (HP:0011063)1.78264432
86Congenital stationary night blindness (HP:0007642)1.77234416
87Abnormality of renal excretion (HP:0011036)1.77179411
88Polyuria (HP:0000103)1.76104390
89Renovascular hypertension (HP:0100817)1.73768222
90Type II lissencephaly (HP:0007260)1.73003754
91Medial flaring of the eyebrow (HP:0010747)1.72661575
92Self-mutilation (HP:0000742)1.71598121
93Hypergonadotropic hypogonadism (HP:0000815)1.69494599
94Abnormal urine output (HP:0012590)1.68396171
95Metaphyseal dysplasia (HP:0100255)1.68321898
96Portal hypertension (HP:0001409)1.66803918
97Morphological abnormality of the middle ear (HP:0008609)1.65384831
98Abnormality of dentin (HP:0010299)1.64936769
99Poor coordination (HP:0002370)1.64233003
100Potter facies (HP:0002009)1.64158743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.47224772
2FRK3.97526977
3MAP4K23.91813700
4MST1R3.81429545
5PLK43.40973866
6TAOK33.36696716
7WNK12.37696071
8CDK122.34339635
9TESK12.20648987
10MAPK152.17634767
11INSRR2.08307625
12SIK22.05994076
13STK392.03491904
14ACVR1B1.94611534
15CAMK1G1.86123081
16NME11.75363219
17STK381.72369759
18BMPR1B1.63352109
19PNCK1.61652934
20BRD41.56895645
21PRKD31.54518754
22DDR21.53340874
23CAMK1D1.51307997
24BLK1.41533601
25MAP3K41.28170564
26MET1.19882385
27MAPK131.18263120
28TNK21.16624756
29NUAK11.16513503
30PTK2B1.08764909
31AKT31.06237223
32TEC1.04512441
33CASK1.01486999
34MAP4K11.00883638
35NEK20.98043357
36OXSR10.95167663
37PIK3CG0.94015896
38KIT0.90551543
39ERBB20.85400128
40EPHA30.84870853
41PLK20.82751156
42TLK10.82385545
43BCKDK0.77872881
44MARK20.75964078
45STK38L0.74853056
46CHUK0.73296870
47MUSK0.72594337
48MARK10.71772813
49PAK30.69245689
50IKBKB0.68182273
51LMTK20.67638300
52PRKAA20.65040359
53WNK30.64565687
54ZAK0.64430092
55CDK30.64372468
56MAP2K60.62086107
57PDK10.61918189
58PRKCH0.61539350
59MAP3K110.61346946
60RPS6KA60.60349491
61SYK0.59146127
62CAMK40.57773997
63MAP3K70.56735503
64ADRBK20.55801474
65TRPM70.54836154
66SGK10.54374527
67MAPK10.54140535
68PIK3CA0.51094965
69CAMK10.50110649
70PRKG10.49971745
71RPS6KA20.49801341
72IKBKE0.49394899
73PRKAA10.48274311
74DYRK1B0.48208161
75ATR0.48082152
76MAP2K70.47517539
77GSK3B0.46380669
78CDK70.46271887
79PRKCQ0.46128521
80MTOR0.45601996
81MAPK110.45338390
82BTK0.44981566
83TNIK0.44867782
84CCNB10.44166750
85SGK20.43531260
86RPS6KL10.43400953
87RPS6KC10.43400953
88DYRK20.41732601
89SGK2230.41074663
90SGK4940.41074663
91MAP2K20.40455958
92CDK20.39713772
93MAPKAPK50.38419090
94GRK10.37902237
95MAPK80.37747511
96FLT30.37444859
97TXK0.36847875
98AKT10.35417223
99CDK10.34551917
100RPS6KA10.33833636

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.57799936
2Olfactory transduction_Homo sapiens_hsa047402.94801839
3Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.84960640
4Fatty acid biosynthesis_Homo sapiens_hsa000612.75963527
5Fanconi anemia pathway_Homo sapiens_hsa034602.63476519
6Butanoate metabolism_Homo sapiens_hsa006502.56686971
7Taste transduction_Homo sapiens_hsa047422.45617166
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39164433
9Dorso-ventral axis formation_Homo sapiens_hsa043202.24797631
10ABC transporters_Homo sapiens_hsa020102.17665123
11Oocyte meiosis_Homo sapiens_hsa041142.00467023
12Salivary secretion_Homo sapiens_hsa049701.87165362
13Phototransduction_Homo sapiens_hsa047441.69144856
14Graft-versus-host disease_Homo sapiens_hsa053321.66992042
15Type I diabetes mellitus_Homo sapiens_hsa049401.66309009
16Primary immunodeficiency_Homo sapiens_hsa053401.66127941
17Homologous recombination_Homo sapiens_hsa034401.63097098
18Allograft rejection_Homo sapiens_hsa053301.62256081
19Autoimmune thyroid disease_Homo sapiens_hsa053201.59638171
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41727906
21Lysine degradation_Homo sapiens_hsa003101.39711155
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.35557210
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30140969
24Notch signaling pathway_Homo sapiens_hsa043301.29793893
25Basal transcription factors_Homo sapiens_hsa030221.29542416
26Nicotine addiction_Homo sapiens_hsa050331.24954962
27Inositol phosphate metabolism_Homo sapiens_hsa005621.24029353
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.23584341
29Asthma_Homo sapiens_hsa053101.17462386
30Circadian entrainment_Homo sapiens_hsa047131.14881541
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14343924
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.13489779
33Protein digestion and absorption_Homo sapiens_hsa049741.12470131
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12052382
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09386175
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08172566
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06749581
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.05766879
39Insulin secretion_Homo sapiens_hsa049111.04518154
40RNA polymerase_Homo sapiens_hsa030201.03644667
41Calcium signaling pathway_Homo sapiens_hsa040201.03114227
42Linoleic acid metabolism_Homo sapiens_hsa005911.02654096
43Antigen processing and presentation_Homo sapiens_hsa046121.02359028
44Platelet activation_Homo sapiens_hsa046110.92467598
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91830460
46RNA transport_Homo sapiens_hsa030130.89328630
47Type II diabetes mellitus_Homo sapiens_hsa049300.88762718
48Renin secretion_Homo sapiens_hsa049240.84475686
49Glutamatergic synapse_Homo sapiens_hsa047240.82051945
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81260647
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80016343
52cAMP signaling pathway_Homo sapiens_hsa040240.79228605
53Long-term depression_Homo sapiens_hsa047300.77045179
54Peroxisome_Homo sapiens_hsa041460.76641427
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.75756953
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66785288
57Cholinergic synapse_Homo sapiens_hsa047250.65346129
58Morphine addiction_Homo sapiens_hsa050320.62550631
59Pancreatic secretion_Homo sapiens_hsa049720.61412108
60Purine metabolism_Homo sapiens_hsa002300.61093776
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58073933
62Serotonergic synapse_Homo sapiens_hsa047260.57918109
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.56854945
64Glycerolipid metabolism_Homo sapiens_hsa005610.55790500
65Sulfur relay system_Homo sapiens_hsa041220.55052271
66Gastric acid secretion_Homo sapiens_hsa049710.53812264
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53800945
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52529130
69RNA degradation_Homo sapiens_hsa030180.52261013
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52217454
71Herpes simplex infection_Homo sapiens_hsa051680.51292155
72MAPK signaling pathway_Homo sapiens_hsa040100.50054130
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49931149
74Ether lipid metabolism_Homo sapiens_hsa005650.48896125
75Ovarian steroidogenesis_Homo sapiens_hsa049130.48623036
76Regulation of autophagy_Homo sapiens_hsa041400.48606641
77Endocytosis_Homo sapiens_hsa041440.46550413
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46383720
79Oxytocin signaling pathway_Homo sapiens_hsa049210.45341736
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.44874405
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44527227
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.42405682
83Huntingtons disease_Homo sapiens_hsa050160.41785932
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40926880
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36733143
86Chemical carcinogenesis_Homo sapiens_hsa052040.36632224
87Influenza A_Homo sapiens_hsa051640.36333320
88Hematopoietic cell lineage_Homo sapiens_hsa046400.36304304
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35421305
90Cardiac muscle contraction_Homo sapiens_hsa042600.35082288
91T cell receptor signaling pathway_Homo sapiens_hsa046600.34629953
92Retinol metabolism_Homo sapiens_hsa008300.33681777
93Base excision repair_Homo sapiens_hsa034100.30022794
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29901493
95ECM-receptor interaction_Homo sapiens_hsa045120.29230155
96Fatty acid degradation_Homo sapiens_hsa000710.28769618
97Choline metabolism in cancer_Homo sapiens_hsa052310.28088761
98Epstein-Barr virus infection_Homo sapiens_hsa051690.27276386
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26758850
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25606765

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