ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.91792685
2	piRNA metabolic process (GO:0034587)	4.50336515
3	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.45435638
4	regulation of cilium movement (GO:0003352)	4.44777450
5	behavioral response to ethanol (GO:0048149)	4.07005043
6	DNA deamination (GO:0045006)	3.87607002
7	ubiquinone biosynthetic process (GO:0006744)	3.81679803
8	protein polyglutamylation (GO:0018095)	3.78302243
9	axoneme assembly (GO:0035082)	3.58673406
10	epithelial cilium movement (GO:0003351)	3.55120283
11	ubiquinone metabolic process (GO:0006743)	3.50672084
12	photoreceptor cell maintenance (GO:0045494)	3.49918535
13	DNA double-strand break processing (GO:0000729)	3.49228629
14	cellular ketone body metabolic process (GO:0046950)	3.47642550
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47335691
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.45387830
17	GPI anchor metabolic process (GO:0006505)	3.44546579
18	fucose catabolic process (GO:0019317)	3.43883875
19	L-fucose metabolic process (GO:0042354)	3.43883875
20	L-fucose catabolic process (GO:0042355)	3.43883875
21	platelet dense granule organization (GO:0060155)	3.40457393
22	nonmotile primary cilium assembly (GO:0035058)	3.35387298
23	intraciliary transport (GO:0042073)	3.34079356
24	seminiferous tubule development (GO:0072520)	3.33816461
25	positive regulation of mitochondrial fission (GO:0090141)	3.32354761
26	mannosylation (GO:0097502)	3.30377986
27	respiratory chain complex IV assembly (GO:0008535)	3.30226122
28	sperm motility (GO:0030317)	3.30089726
29	behavioral response to nicotine (GO:0035095)	3.28818384
30	quinone biosynthetic process (GO:1901663)	3.26646908
31	centriole replication (GO:0007099)	3.26118694
32	protein complex biogenesis (GO:0070271)	3.23492056
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.21954012
34	detection of light stimulus involved in visual perception (GO:0050908)	3.21954012
35	indolalkylamine metabolic process (GO:0006586)	3.16032299
36	neural tube formation (GO:0001841)	3.15484022
37	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13087712
38	cytochrome complex assembly (GO:0017004)	3.13078529
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12674910
40	retinal cone cell development (GO:0046549)	3.12497822
41	ketone body metabolic process (GO:1902224)	3.12253998
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11867869
43	GPI anchor biosynthetic process (GO:0006506)	3.09135381
44	branched-chain amino acid catabolic process (GO:0009083)	3.08458584
45	cilium or flagellum-dependent cell motility (GO:0001539)	3.08373797
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07636584
47	DNA integration (GO:0015074)	3.05460074
48	replication fork processing (GO:0031297)	3.02940122
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01693057
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01693057
51	NADH dehydrogenase complex assembly (GO:0010257)	3.01693057
52	pyrimidine dimer repair (GO:0006290)	2.97983573
53	gamma-aminobutyric acid transport (GO:0015812)	2.94539046
54	cilium morphogenesis (GO:0060271)	2.94219721
55	mismatch repair (GO:0006298)	2.94153317
56	microtubule severing (GO:0051013)	2.93942446
57	cilium organization (GO:0044782)	2.93090622
58	tryptophan catabolic process (GO:0006569)	2.92428308
59	indole-containing compound catabolic process (GO:0042436)	2.92428308
60	indolalkylamine catabolic process (GO:0046218)	2.92428308
61	tryptophan metabolic process (GO:0006568)	2.91843891
62	negative regulation of telomere maintenance (GO:0032205)	2.89441595
63	regulation of microtubule-based movement (GO:0060632)	2.88661364
64	cilium movement (GO:0003341)	2.87922753
65	opioid receptor signaling pathway (GO:0038003)	2.87894809
66	DNA methylation involved in gamete generation (GO:0043046)	2.87797869
67	cilium assembly (GO:0042384)	2.86935733
68	establishment of protein localization to Golgi (GO:0072600)	2.83540928
69	water-soluble vitamin biosynthetic process (GO:0042364)	2.80447792
70	reciprocal DNA recombination (GO:0035825)	2.76910216
71	reciprocal meiotic recombination (GO:0007131)	2.76910216
72	glycolipid biosynthetic process (GO:0009247)	2.75598713
73	C4-dicarboxylate transport (GO:0015740)	2.74565714
74	regulation of meiosis I (GO:0060631)	2.74275500
75	ncRNA catabolic process (GO:0034661)	2.73524995
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72878765
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72878765
78	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.72679803
79	photoreceptor cell development (GO:0042461)	2.72298866
80	recombinational repair (GO:0000725)	2.71541358
81	acrosome reaction (GO:0007340)	2.70632084
82	double-strand break repair via homologous recombination (GO:0000724)	2.69630773
83	spermatid development (GO:0007286)	2.66085820
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65953411
85	C-terminal protein lipidation (GO:0006501)	2.65307154
86	multicellular organism reproduction (GO:0032504)	2.62803894
87	neuronal action potential (GO:0019228)	2.62489553
88	protein targeting to Golgi (GO:0000042)	2.62191152
89	histone mRNA catabolic process (GO:0071044)	2.61683683
90	GMP metabolic process (GO:0046037)	2.61328936
91	regulation of telomere maintenance (GO:0032204)	2.60828728
92	branched-chain amino acid metabolic process (GO:0009081)	2.58067993
93	anterograde synaptic vesicle transport (GO:0048490)	2.55382868
94	pyrimidine nucleobase catabolic process (GO:0006208)	2.55192002
95	resolution of meiotic recombination intermediates (GO:0000712)	2.55176550
96	estrogen biosynthetic process (GO:0006703)	2.54462813
97	base-excision repair, AP site formation (GO:0006285)	2.54089574
98	histone H2A acetylation (GO:0043968)	2.52889936
99	protein localization to Golgi apparatus (GO:0034067)	2.52453290
100	adenosine metabolic process (GO:0046085)	2.52200830

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.12348711
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33294154
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08182018
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03530353
5	VDR_22108803_ChIP-Seq_LS180_Human	2.93927463
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.56987990
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53667534
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44334542
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34517425
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30088547
11	FUS_26573619_Chip-Seq_HEK293_Human	2.22791914
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21025853
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.14692893
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12232658
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.12230010
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08083060
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.07250647
18	EWS_26573619_Chip-Seq_HEK293_Human	2.05016676
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.02880096
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00339640
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94179222
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.90820217
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.90820217
24	P300_19829295_ChIP-Seq_ESCs_Human	1.86810882
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.82013237
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75102337
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71181419
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69461013
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.68875733
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67965333
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.65258358
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55877029
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55877029
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.52764131
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50069145
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.48887902
37	STAT3_23295773_ChIP-Seq_U87_Human	1.45569132
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43338936
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43333378
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43009807
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43009807
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41748114
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39373035
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39189207
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37745353
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36925394
47	TCF4_23295773_ChIP-Seq_U87_Human	1.36247045
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.33616967
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32894564
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.30956181
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28606938
52	AR_25329375_ChIP-Seq_VCAP_Human	1.27378357
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24195772
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22342538
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22342538
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20491140
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.20151542
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19518636
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18554145
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17884693
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17516321
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17277715
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16284830
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15643991
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.14895212
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14689736
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14078351
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13611221
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.11765292
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11458644
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11138819
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10908705
73	NCOR_22424771_ChIP-Seq_293T_Human	1.10082765
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09369533
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09200292
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07751198
77	AR_20517297_ChIP-Seq_VCAP_Human	1.07342861
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07288094
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06822382
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06148688
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05751489
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05732154
83	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.05558605
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04782799
85	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04232023
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03555690
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03509248
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01220870
89	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00965420
90	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00461783
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98882007
92	ERA_21632823_ChIP-Seq_H3396_Human	0.97763541
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97053128
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96739678
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95912465
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95787168
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95426693
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95118490
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.94450568
100	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.94003866

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.47079272
2	MP0001968_abnormal_touch/_nociception	2.89339369
3	MP0008877_abnormal_DNA_methylation	2.88089360
4	MP0005551_abnormal_eye_electrophysiolog	2.67711321
5	MP0002102_abnormal_ear_morphology	2.61427558
6	MP0005646_abnormal_pituitary_gland	2.39272788
7	MP0008058_abnormal_DNA_repair	2.14578609
8	MP0006072_abnormal_retinal_apoptosis	2.12049294
9	MP0005645_abnormal_hypothalamus_physiol	2.11808927
10	MP0003787_abnormal_imprinting	2.04410591
11	MP0001986_abnormal_taste_sensitivity	1.98949668
12	MP0005410_abnormal_fertilization	1.94144012
13	MP0000015_abnormal_ear_pigmentation	1.89076001
14	MP0000569_abnormal_digit_pigmentation	1.88165718
15	MP0006292_abnormal_olfactory_placode	1.87605799
16	MP0005253_abnormal_eye_physiology	1.82571966
17	MP0002736_abnormal_nociception_after	1.82179264
18	MP0001486_abnormal_startle_reflex	1.80446860
19	MP0000372_irregular_coat_pigmentation	1.78311874
20	MP0002735_abnormal_chemical_nociception	1.76069609
21	MP0002876_abnormal_thyroid_physiology	1.75761403
22	MP0006276_abnormal_autonomic_nervous	1.71641852
23	MP0008995_early_reproductive_senescence	1.71186880
24	MP0003136_yellow_coat_color	1.69603137
25	MP0004147_increased_porphyrin_level	1.69480411
26	MP0009046_muscle_twitch	1.65572866
27	MP0001529_abnormal_vocalization	1.64535634
28	MP0004043_abnormal_pH_regulation	1.63796950
29	MP0002638_abnormal_pupillary_reflex	1.60171446
30	MP0008872_abnormal_physiological_respon	1.59585282
31	MP0008875_abnormal_xenobiotic_pharmacok	1.56588514
32	MP0009745_abnormal_behavioral_response	1.55902326
33	MP0003718_maternal_effect	1.54970931
34	MP0006035_abnormal_mitochondrial_morpho	1.54874388
35	MP0002272_abnormal_nervous_system	1.51210533
36	MP0005075_abnormal_melanosome_morpholog	1.49684597
37	MP0002653_abnormal_ependyma_morphology	1.46397102
38	MP0001501_abnormal_sleep_pattern	1.45179579
39	MP0001984_abnormal_olfaction	1.43159748
40	MP0003195_calcinosis	1.41940012
41	MP0003646_muscle_fatigue	1.40781864
42	MP0003698_abnormal_male_reproductive	1.36682404
43	MP0002837_dystrophic_cardiac_calcinosis	1.36204042
44	MP0002234_abnormal_pharynx_morphology	1.34999820
45	MP0008789_abnormal_olfactory_epithelium	1.34269175
46	MP0009278_abnormal_bone_marrow	1.33145600
47	MP0010386_abnormal_urinary_bladder	1.30989847
48	MP0001929_abnormal_gametogenesis	1.30380538
49	MP0001764_abnormal_homeostasis	1.28411726
50	MP0002095_abnormal_skin_pigmentation	1.23524615
51	MP0002733_abnormal_thermal_nociception	1.22538115
52	MP0005423_abnormal_somatic_nervous	1.19439899
53	MP0003122_maternal_imprinting	1.19179705
54	MP0002572_abnormal_emotion/affect_behav	1.18245613
55	MP0001970_abnormal_pain_threshold	1.16222233
56	MP0003121_genomic_imprinting	1.15883601
57	MP0000631_abnormal_neuroendocrine_gland	1.14004044
58	MP0005499_abnormal_olfactory_system	1.13808113
59	MP0005394_taste/olfaction_phenotype	1.13808113
60	MP0004142_abnormal_muscle_tone	1.13079731
61	MP0005084_abnormal_gallbladder_morpholo	1.12277061
62	MP0003011_delayed_dark_adaptation	1.11974616
63	MP0004133_heterotaxia	1.07336873
64	MP0002067_abnormal_sensory_capabilities	1.06741609
65	MP0002557_abnormal_social/conspecific_i	1.06257132
66	MP0001485_abnormal_pinna_reflex	1.05248963
67	MP0001905_abnormal_dopamine_level	1.04622381
68	MP0009764_decreased_sensitivity_to	1.03707502
69	MP0002938_white_spotting	1.03553193
70	MP0006036_abnormal_mitochondrial_physio	1.02485600
71	MP0002064_seizures	1.00550649
72	MP0004742_abnormal_vestibular_system	1.00307164
73	MP0010094_abnormal_chromosome_stability	0.99519239
74	MP0005174_abnormal_tail_pigmentation	0.98661538
75	MP0003635_abnormal_synaptic_transmissio	0.98438660
76	MP0001324_abnormal_eye_pigmentation	0.97441027
77	MP0002734_abnormal_mechanical_nocicepti	0.94340756
78	MP0001963_abnormal_hearing_physiology	0.94330129
79	MP0000778_abnormal_nervous_system	0.93989904
80	MP0001545_abnormal_hematopoietic_system	0.92423303
81	MP0005397_hematopoietic_system_phenotyp	0.92423303
82	MP0002751_abnormal_autonomic_nervous	0.92244571
83	MP0002160_abnormal_reproductive_system	0.92014857
84	MP0002229_neurodegeneration	0.91010317
85	MP0002752_abnormal_somatic_nervous	0.89557896
86	MP0005367_renal/urinary_system_phenotyp	0.89389179
87	MP0000516_abnormal_urinary_system	0.89389179
88	MP0005195_abnormal_posterior_eye	0.87265561
89	MP0002210_abnormal_sex_determination	0.86069355
90	MP0000465_gastrointestinal_hemorrhage	0.85463116
91	MP0000653_abnormal_sex_gland	0.85043448
92	MP0003786_premature_aging	0.84195568
93	MP0008775_abnormal_heart_ventricle	0.82742793
94	MP0005171_absent_coat_pigmentation	0.82494438
95	MP0005389_reproductive_system_phenotype	0.81022535
96	MP0004924_abnormal_behavior	0.80747972
97	MP0005386_behavior/neurological_phenoty	0.80747972
98	MP0005167_abnormal_blood-brain_barrier	0.79498337
99	MP0000427_abnormal_hair_cycle	0.78631757
100	MP0002069_abnormal_eating/drinking_beha	0.77654552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.19901725
2	Pancreatic fibrosis (HP:0100732)	4.03863251
3	True hermaphroditism (HP:0010459)	3.89372242
4	Abnormality of midbrain morphology (HP:0002418)	3.54607268
5	Molar tooth sign on MRI (HP:0002419)	3.54607268
6	Nephronophthisis (HP:0000090)	3.43250298
7	Medial flaring of the eyebrow (HP:0010747)	3.41700989
8	Thyroid-stimulating hormone excess (HP:0002925)	3.21716954
9	Abnormality of the renal medulla (HP:0100957)	3.06554933
10	Tubulointerstitial nephritis (HP:0001970)	2.97358123
11	Abnormality of the renal cortex (HP:0011035)	2.91269262
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.89715838
13	Congenital stationary night blindness (HP:0007642)	2.87265078
14	Chronic hepatic failure (HP:0100626)	2.85788949
15	Gait imbalance (HP:0002141)	2.85100757
16	Congenital primary aphakia (HP:0007707)	2.83115451
17	Attenuation of retinal blood vessels (HP:0007843)	2.80513651
18	Nephrogenic diabetes insipidus (HP:0009806)	2.77286326
19	Cystic liver disease (HP:0006706)	2.70723345
20	Hepatocellular necrosis (HP:0001404)	2.69681369
21	Progressive inability to walk (HP:0002505)	2.66484234
22	Focal motor seizures (HP:0011153)	2.65495179
23	Type II lissencephaly (HP:0007260)	2.63199082
24	Renal cortical cysts (HP:0000803)	2.55992550
25	Abnormality of macular pigmentation (HP:0008002)	2.54965583
26	Abolished electroretinogram (ERG) (HP:0000550)	2.54538193
27	Short tibia (HP:0005736)	2.53494847
28	Abnormal biliary tract physiology (HP:0012439)	2.52895078
29	Bile duct proliferation (HP:0001408)	2.52895078
30	Inability to walk (HP:0002540)	2.51943236
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.49697954
32	Hyperventilation (HP:0002883)	2.48715034
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47868075
34	Hepatic necrosis (HP:0002605)	2.45992810
35	Gaze-evoked nystagmus (HP:0000640)	2.41568429
36	Mitochondrial inheritance (HP:0001427)	2.40794278
37	Pendular nystagmus (HP:0012043)	2.40552266
38	Intestinal atresia (HP:0011100)	2.40235729
39	Increased CSF lactate (HP:0002490)	2.38375398
40	Severe visual impairment (HP:0001141)	2.35819645
41	3-Methylglutaconic aciduria (HP:0003535)	2.35707193
42	Genital tract atresia (HP:0001827)	2.34144594
43	Volvulus (HP:0002580)	2.30060802
44	Congenital hepatic fibrosis (HP:0002612)	2.29106405
45	Lissencephaly (HP:0001339)	2.28679704
46	Postaxial foot polydactyly (HP:0001830)	2.28081016
47	Abnormality of the ileum (HP:0001549)	2.24791474
48	Cerebellar dysplasia (HP:0007033)	2.24226127
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22386267
50	Absent/shortened dynein arms (HP:0200106)	2.22386267
51	Vaginal atresia (HP:0000148)	2.19254093
52	Methylmalonic acidemia (HP:0002912)	2.18827046
53	Tubular atrophy (HP:0000092)	2.17162940
54	Type I transferrin isoform profile (HP:0003642)	2.16029522
55	Colon cancer (HP:0003003)	2.15599253
56	Absent speech (HP:0001344)	2.12982185
57	Abnormal protein glycosylation (HP:0012346)	2.09573655
58	Abnormal glycosylation (HP:0012345)	2.09573655
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09573655
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.09573655
61	Anencephaly (HP:0002323)	2.09243216
62	Decreased central vision (HP:0007663)	2.08210288
63	Bony spicule pigmentary retinopathy (HP:0007737)	2.08207517
64	Broad-based gait (HP:0002136)	2.07948989
65	Keratoconus (HP:0000563)	2.07802752
66	Increased corneal curvature (HP:0100692)	2.07802752
67	Tubulointerstitial abnormality (HP:0001969)	2.06372967
68	Sclerocornea (HP:0000647)	2.05420112
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04500828
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04258616
71	Acute necrotizing encephalopathy (HP:0006965)	2.03863962
72	Abnormality of the labia minora (HP:0012880)	2.00979380
73	Acute encephalopathy (HP:0006846)	2.00668522
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.98285371
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98285371
76	Retinitis pigmentosa (HP:0000510)	1.98171098
77	Hyperglycinemia (HP:0002154)	1.97295850
78	Lipid accumulation in hepatocytes (HP:0006561)	1.95949813
79	Large for gestational age (HP:0001520)	1.95779717
80	Polydipsia (HP:0001959)	1.95196116
81	Abnormal drinking behavior (HP:0030082)	1.95196116
82	Progressive microcephaly (HP:0000253)	1.94204770
83	Occipital encephalocele (HP:0002085)	1.93664526
84	Hyperglycinuria (HP:0003108)	1.92483401
85	Optic nerve hypoplasia (HP:0000609)	1.91679070
86	Increased hepatocellular lipid droplets (HP:0006565)	1.90626448
87	Poor coordination (HP:0002370)	1.89950799
88	Sloping forehead (HP:0000340)	1.88268052
89	Renal Fanconi syndrome (HP:0001994)	1.86483587
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.86481997
91	Abnormality of alanine metabolism (HP:0010916)	1.86481997
92	Hyperalaninemia (HP:0003348)	1.86481997
93	Clubbing of toes (HP:0100760)	1.86218711
94	Astigmatism (HP:0000483)	1.85245196
95	Meckel diverticulum (HP:0002245)	1.84764258
96	Polyuria (HP:0000103)	1.83436897
97	Increased serum lactate (HP:0002151)	1.83418226
98	Methylmalonic aciduria (HP:0012120)	1.82784736
99	Hypothermia (HP:0002045)	1.81461760
100	Postaxial hand polydactyly (HP:0001162)	1.80642269

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.72670023
2	MAP4K2	4.38207868
3	NUAK1	3.18762928
4	ADRBK2	2.93991003
5	WNK3	2.67283040
6	BCKDK	2.50953963
7	MAP3K4	2.27374580
8	MAPK13	2.19715376
9	ZAK	2.16046100
10	INSRR	2.12529271
11	TAOK3	2.00015895
12	VRK2	1.98575237
13	BMPR1B	1.96137106
14	TRIM28	1.94396603
15	PINK1	1.91526832
16	MAP2K7	1.85651661
17	PLK4	1.69065685
18	CSNK1G3	1.62600078
19	CASK	1.60881845
20	CSNK1A1L	1.50970199
21	MARK1	1.50359911
22	NEK1	1.48936963
23	EIF2AK3	1.44557859
24	CSNK1G2	1.43935256
25	PLK2	1.39610133
26	BCR	1.38827799
27	WNK4	1.34217568
28	CSNK1G1	1.34201755
29	GRK1	1.19350894
30	VRK1	1.15305998
31	MKNK1	1.13227668
32	STK38L	1.05700838
33	STK39	1.04244207
34	SRPK1	1.03274521
35	OXSR1	1.02857909
36	CCNB1	1.02765850
37	PRKCE	0.98999523
38	ADRBK1	0.95411645
39	MKNK2	0.94792717
40	DYRK2	0.94723108
41	MAPKAPK5	0.85432975
42	ACVR1B	0.82691706
43	PAK3	0.81177540
44	PRKCG	0.80372063
45	PIK3CA	0.79642373
46	FLT3	0.79227152
47	TEC	0.78006516
48	KIT	0.77054839
49	TNIK	0.72193730
50	PLK3	0.71967170
51	MAPKAPK3	0.71748294
52	BRSK2	0.71395658
53	STK16	0.69061198
54	FER	0.68662225
55	EPHA4	0.68616750
56	ATR	0.68275317
57	TLK1	0.67803218
58	NEK2	0.61897336
59	PNCK	0.61422357
60	ERBB3	0.61368088
61	TGFBR1	0.58236598
62	CDK3	0.57427171
63	AKT3	0.56984238
64	LATS1	0.56326001
65	CDK19	0.56116588
66	PDK2	0.54846476
67	WEE1	0.54267170
68	TIE1	0.53484692
69	CAMK2A	0.53211595
70	TXK	0.50279354
71	MAP2K4	0.49886606
72	RPS6KA4	0.49840080
73	CSNK1A1	0.49566169
74	IRAK1	0.49175464
75	TNK2	0.49135983
76	PIM2	0.47860077
77	PRKCQ	0.47036923
78	RPS6KA5	0.45535628
79	PLK1	0.44162989
80	PKN1	0.43485064
81	PTK2B	0.43056606
82	ATM	0.42407374
83	EIF2AK1	0.40869888
84	DYRK3	0.40285689
85	MINK1	0.40083303
86	CSNK1D	0.39306723
87	TAF1	0.38506713
88	PRKACA	0.37888898
89	IKBKB	0.37637316
90	CAMKK2	0.37283619
91	EPHA3	0.35746672
92	CHEK2	0.35504155
93	NTRK2	0.34845496
94	ABL1	0.34396935
95	DYRK1A	0.34036549
96	GRK5	0.33166787
97	EIF2AK2	0.32874026
98	PHKG1	0.31784693
99	PHKG2	0.31784693
100	STK38	0.29918720

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.59510066
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.15598199
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.01324689
4	Butanoate metabolism_Homo sapiens_hsa00650	2.97369176
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.75262524
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.57275925
7	Phototransduction_Homo sapiens_hsa04744	2.39916796
8	Homologous recombination_Homo sapiens_hsa03440	2.24892263
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23547776
10	Propanoate metabolism_Homo sapiens_hsa00640	2.13313672
11	Peroxisome_Homo sapiens_hsa04146	1.90393778
12	RNA polymerase_Homo sapiens_hsa03020	1.89020774
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.87220478
14	Protein export_Homo sapiens_hsa03060	1.83678591
15	Basal transcription factors_Homo sapiens_hsa03022	1.80177420
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.76345780
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69853680
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67957908
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64767344
20	Base excision repair_Homo sapiens_hsa03410	1.62654544
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62144054
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60676309
23	Olfactory transduction_Homo sapiens_hsa04740	1.58103508
24	Nicotine addiction_Homo sapiens_hsa05033	1.55426362
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51115091
26	RNA degradation_Homo sapiens_hsa03018	1.50889202
27	Taste transduction_Homo sapiens_hsa04742	1.46548297
28	Regulation of autophagy_Homo sapiens_hsa04140	1.39635219
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.38876398
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.37294848
31	Proteasome_Homo sapiens_hsa03050	1.35179497
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34829870
33	Parkinsons disease_Homo sapiens_hsa05012	1.33914684
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.32766851
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31468920
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.27709752
37	ABC transporters_Homo sapiens_hsa02010	1.23935302
38	Caffeine metabolism_Homo sapiens_hsa00232	1.10598391
39	Purine metabolism_Homo sapiens_hsa00230	1.08421258
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06846346
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06132217
42	Huntingtons disease_Homo sapiens_hsa05016	1.05915136
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98565579
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97205943
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96425425
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91950349
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89741102
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.89121471
49	RNA transport_Homo sapiens_hsa03013	0.88819537
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87445403
51	Metabolic pathways_Homo sapiens_hsa01100	0.83463083
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83126726
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83110538
54	Fatty acid degradation_Homo sapiens_hsa00071	0.82533213
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82168512
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79761929
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78661349
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78575353
59	Fatty acid elongation_Homo sapiens_hsa00062	0.78345125
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.77705741
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77470468
62	One carbon pool by folate_Homo sapiens_hsa00670	0.77152705
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.76636900
64	Retinol metabolism_Homo sapiens_hsa00830	0.76494934
65	Mismatch repair_Homo sapiens_hsa03430	0.74501186
66	Morphine addiction_Homo sapiens_hsa05032	0.73017380
67	Asthma_Homo sapiens_hsa05310	0.71815431
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70793990
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69750664
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68536187
71	Salivary secretion_Homo sapiens_hsa04970	0.66468637
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64482587
73	Alzheimers disease_Homo sapiens_hsa05010	0.64375999
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63564844
75	Circadian entrainment_Homo sapiens_hsa04713	0.58946196
76	GABAergic synapse_Homo sapiens_hsa04727	0.57592700
77	Glutathione metabolism_Homo sapiens_hsa00480	0.57435886
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55572254
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53966293
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51393317
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50208641
82	Oocyte meiosis_Homo sapiens_hsa04114	0.49290839
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48019613
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.47909766
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.46485212
86	Serotonergic synapse_Homo sapiens_hsa04726	0.43084311
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42488576
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.41572582
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40959222
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38817257
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.35217427
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34934940
93	Lysine degradation_Homo sapiens_hsa00310	0.34328129
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34097905
95	Spliceosome_Homo sapiens_hsa03040	0.33356719
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32544830
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30962786
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30493036
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28323202
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.28031865

SPDYE11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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