ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.80995711
2	protein polyglutamylation (GO:0018095)	4.68222253
3	DNA double-strand break processing (GO:0000729)	4.49981383
4	rRNA methylation (GO:0031167)	4.13324852
5	negative regulation of telomere maintenance (GO:0032205)	4.07983638
6	rRNA modification (GO:0000154)	3.96594993
7	cell wall macromolecule catabolic process (GO:0016998)	3.92551742
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.90928692
9	sperm motility (GO:0030317)	3.87426604
10	cellular ketone body metabolic process (GO:0046950)	3.76074391
11	ubiquinone biosynthetic process (GO:0006744)	3.69456200
12	protein deneddylation (GO:0000338)	3.66974031
13	respiratory chain complex IV assembly (GO:0008535)	3.64920600
14	response to pheromone (GO:0019236)	3.60753583
15	protein-cofactor linkage (GO:0018065)	3.57870856
16	L-fucose catabolic process (GO:0042355)	3.57677678
17	fucose catabolic process (GO:0019317)	3.57677678
18	L-fucose metabolic process (GO:0042354)	3.57677678
19	L-methionine salvage (GO:0071267)	3.56025649
20	L-methionine biosynthetic process (GO:0071265)	3.56025649
21	amino acid salvage (GO:0043102)	3.56025649
22	ubiquinone metabolic process (GO:0006743)	3.54486248
23	axoneme assembly (GO:0035082)	3.53749525
24	cell wall macromolecule metabolic process (GO:0044036)	3.51719346
25	spermatid nucleus differentiation (GO:0007289)	3.51487149
26	maturation of 5.8S rRNA (GO:0000460)	3.49820652
27	heme transport (GO:0015886)	3.48826572
28	cytochrome complex assembly (GO:0017004)	3.46020231
29	pyrimidine dimer repair (GO:0006290)	3.45648506
30	positive regulation of mitochondrial fission (GO:0090141)	3.44791562
31	regulation of mitochondrial translation (GO:0070129)	3.44371748
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.43828232
33	GPI anchor metabolic process (GO:0006505)	3.41893477
34	nonmotile primary cilium assembly (GO:0035058)	3.41133498
35	regulation of cilium movement (GO:0003352)	3.36555611
36	ketone body metabolic process (GO:1902224)	3.27124504
37	cellular response to interferon-beta (GO:0035458)	3.25271940
38	protein complex biogenesis (GO:0070271)	3.25225395
39	cullin deneddylation (GO:0010388)	3.22052138
40	behavioral response to nicotine (GO:0035095)	3.20101468
41	indolalkylamine metabolic process (GO:0006586)	3.19917447
42	photoreceptor cell maintenance (GO:0045494)	3.19279702
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.19221361
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.19221361
45	mannosylation (GO:0097502)	3.16416697
46	platelet dense granule organization (GO:0060155)	3.14991614
47	quinone biosynthetic process (GO:1901663)	3.11995206
48	kynurenine metabolic process (GO:0070189)	3.11809943
49	branched-chain amino acid catabolic process (GO:0009083)	3.10585187
50	regulation of mitochondrial fission (GO:0090140)	3.10128116
51	GPI anchor biosynthetic process (GO:0006506)	3.04289040
52	positive regulation of prostaglandin secretion (GO:0032308)	3.03994051
53	methionine biosynthetic process (GO:0009086)	3.01635726
54	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.99760923
55	gamma-aminobutyric acid transport (GO:0015812)	2.97379038
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96663718
57	cellular response to exogenous dsRNA (GO:0071360)	2.95780876
58	lipopolysaccharide biosynthetic process (GO:0009103)	2.94557294
59	retinal cone cell development (GO:0046549)	2.94224803
60	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.92241139
61	regulation of telomere maintenance (GO:0032204)	2.92175121
62	cilium morphogenesis (GO:0060271)	2.90098667
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88201132
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88201132
65	NADH dehydrogenase complex assembly (GO:0010257)	2.88201132
66	tryptophan metabolic process (GO:0006568)	2.87648500
67	cellular biogenic amine catabolic process (GO:0042402)	2.87265750
68	amine catabolic process (GO:0009310)	2.87265750
69	aspartate family amino acid biosynthetic process (GO:0009067)	2.86774245
70	GMP metabolic process (GO:0046037)	2.86173663
71	epithelial cilium movement (GO:0003351)	2.85457956
72	replication fork processing (GO:0031297)	2.84756373
73	tryptophan catabolic process (GO:0006569)	2.84747636
74	indole-containing compound catabolic process (GO:0042436)	2.84747636
75	indolalkylamine catabolic process (GO:0046218)	2.84747636
76	DNA integration (GO:0015074)	2.84319113
77	reciprocal DNA recombination (GO:0035825)	2.84093950
78	reciprocal meiotic recombination (GO:0007131)	2.84093950
79	mitochondrion distribution (GO:0048311)	2.83365582
80	acrosome reaction (GO:0007340)	2.82796527
81	organic cation transport (GO:0015695)	2.81629870
82	C-terminal protein lipidation (GO:0006501)	2.80433331
83	S-adenosylmethionine metabolic process (GO:0046500)	2.71806201
84	phosphatidylethanolamine metabolic process (GO:0046337)	2.70767041
85	aldehyde catabolic process (GO:0046185)	2.64679630
86	multicellular organism reproduction (GO:0032504)	2.64516057
87	C-terminal protein amino acid modification (GO:0018410)	2.63588331
88	mismatch repair (GO:0006298)	2.61414888
89	regulation of vacuole organization (GO:0044088)	2.60387744
90	axonemal dynein complex assembly (GO:0070286)	2.58223583
91	intraciliary transport (GO:0042073)	2.57072902
92	mitochondrial RNA metabolic process (GO:0000959)	2.55827135
93	branched-chain amino acid metabolic process (GO:0009081)	2.55507286
94	cilium or flagellum-dependent cell motility (GO:0001539)	2.53908992
95	glycolipid biosynthetic process (GO:0009247)	2.53740344
96	inositol phosphate catabolic process (GO:0071545)	2.53354157
97	spermatid development (GO:0007286)	2.52056260
98	peptidyl-arginine omega-N-methylation (GO:0035247)	2.50911155
99	microtubule severing (GO:0051013)	2.50520844
100	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.50052272

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.31166203
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.76716467
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.53840353
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17594088
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89222092
6	VDR_22108803_ChIP-Seq_LS180_Human	2.87761038
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77957091
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.76938143
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59246588
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.59031523
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30008946
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.23509517
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23468090
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16616778
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16608413
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.05066869
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.03820732
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02177632
19	FUS_26573619_Chip-Seq_HEK293_Human	1.99223907
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.95550685
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.93557282
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91475667
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90651898
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.87353396
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.85750425
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.79193803
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.63066955
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62964289
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61465870
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.61039244
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61039244
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.59857355
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56059827
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55235538
35	EWS_26573619_Chip-Seq_HEK293_Human	1.49617541
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.44071226
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43904627
38	P300_19829295_ChIP-Seq_ESCs_Human	1.43678308
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43508697
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42761201
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42424999
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39828571
43	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36939423
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33139967
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.32213415
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.30037043
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29353577
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.29082644
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28781028
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25030779
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22249568
52	STAT3_23295773_ChIP-Seq_U87_Human	1.21611780
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19077528
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19077528
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17878642
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15331483
57	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13272042
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13121558
59	AR_20517297_ChIP-Seq_VCAP_Human	1.12664474
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.10994376
61	AR_25329375_ChIP-Seq_VCAP_Human	1.10365934
62	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08914105
63	TCF4_23295773_ChIP-Seq_U87_Human	1.08877662
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07921459
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07921459
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07649124
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07620002
68	ERA_21632823_ChIP-Seq_H3396_Human	1.07437133
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07359116
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.06925668
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.05443492
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05129360
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05042825
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03179341
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03004510
76	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.02865940
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02672793
78	NCOR_22424771_ChIP-Seq_293T_Human	1.02067294
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02023601
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02023601
81	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.01157393
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00515757
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00343998
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98362707
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97179350
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96148485
87	GATA3_26560356_Chip-Seq_TH2_Human	0.95935804
88	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94488158
89	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93560512
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93371899
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92906745
92	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92064971
93	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91754203
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90238319
95	RAC3_21632823_ChIP-Seq_H3396_Human	0.89765435
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89258974
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.88709038
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88613949
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88559075
100	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87772939

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.14861021
2	MP0001968_abnormal_touch/_nociception	3.03082796
3	MP0004147_increased_porphyrin_level	2.86197356
4	MP0000569_abnormal_digit_pigmentation	2.80196445
5	MP0002102_abnormal_ear_morphology	2.57982134
6	MP0005645_abnormal_hypothalamus_physiol	2.56738793
7	MP0005646_abnormal_pituitary_gland	2.48495709
8	MP0005551_abnormal_eye_electrophysiolog	2.28106196
9	MP0008875_abnormal_xenobiotic_pharmacok	2.23116997
10	MP0001986_abnormal_taste_sensitivity	2.20220220
11	MP0002735_abnormal_chemical_nociception	2.16587519
12	MP0008058_abnormal_DNA_repair	2.16054582
13	MP0004043_abnormal_pH_regulation	2.11606395
14	MP0009046_muscle_twitch	2.05587940
15	MP0000427_abnormal_hair_cycle	2.00616898
16	MP0001529_abnormal_vocalization	1.98961993
17	MP0003136_yellow_coat_color	1.88566954
18	MP0006072_abnormal_retinal_apoptosis	1.86091944
19	MP0001501_abnormal_sleep_pattern	1.85302870
20	MP0002733_abnormal_thermal_nociception	1.84925137
21	MP0002837_dystrophic_cardiac_calcinosis	1.82951919
22	MP0005253_abnormal_eye_physiology	1.81473483
23	MP0001905_abnormal_dopamine_level	1.79212940
24	MP0009697_abnormal_copulation	1.74037245
25	MP0003698_abnormal_male_reproductive	1.73817109
26	MP0000631_abnormal_neuroendocrine_gland	1.72336359
27	MP0006276_abnormal_autonomic_nervous	1.71151250
28	MP0003786_premature_aging	1.67895836
29	MP0001486_abnormal_startle_reflex	1.66592387
30	MP0002234_abnormal_pharynx_morphology	1.64923025
31	MP0006292_abnormal_olfactory_placode	1.61825961
32	MP0008877_abnormal_DNA_methylation	1.61625563
33	MP0002736_abnormal_nociception_after	1.61165414
34	MP0001929_abnormal_gametogenesis	1.58446541
35	MP0002734_abnormal_mechanical_nocicepti	1.55884146
36	MP0005167_abnormal_blood-brain_barrier	1.54619012
37	MP0000013_abnormal_adipose_tissue	1.52858079
38	MP0004142_abnormal_muscle_tone	1.48546765
39	MP0003880_abnormal_central_pattern	1.48280167
40	MP0001919_abnormal_reproductive_system	1.43471599
41	MP0001984_abnormal_olfaction	1.42006783
42	MP0004145_abnormal_muscle_electrophysio	1.41313068
43	MP0008995_early_reproductive_senescence	1.40988435
44	MP0003718_maternal_effect	1.39073207
45	MP0001970_abnormal_pain_threshold	1.38848449
46	MP0003693_abnormal_embryo_hatching	1.38758237
47	MP0008872_abnormal_physiological_respon	1.36607195
48	MP0009745_abnormal_behavioral_response	1.35482696
49	MP0006036_abnormal_mitochondrial_physio	1.30838837
50	MP0002272_abnormal_nervous_system	1.29805654
51	MP0002160_abnormal_reproductive_system	1.27427082
52	MP0005389_reproductive_system_phenotype	1.27108990
53	MP0003646_muscle_fatigue	1.25355754
54	MP0001764_abnormal_homeostasis	1.22676819
55	MP0001661_extended_life_span	1.19900677
56	MP0002572_abnormal_emotion/affect_behav	1.19838262
57	MP0004270_analgesia	1.19332182
58	MP0008775_abnormal_heart_ventricle	1.18792366
59	MP0002064_seizures	1.13392363
60	MP0003195_calcinosis	1.11780415
61	MP0005379_endocrine/exocrine_gland_phen	1.10865466
62	MP0002653_abnormal_ependyma_morphology	1.08862463
63	MP0004924_abnormal_behavior	1.08285932
64	MP0005386_behavior/neurological_phenoty	1.08285932
65	MP0001727_abnormal_embryo_implantation	1.04543088
66	MP0000372_irregular_coat_pigmentation	1.03694524
67	MP0005075_abnormal_melanosome_morpholog	1.01499587
68	MP0003119_abnormal_digestive_system	1.00183959
69	MP0003567_abnormal_fetal_cardiomyocyte	0.99714162
70	MP0000015_abnormal_ear_pigmentation	0.95732214
71	MP0002638_abnormal_pupillary_reflex	0.95673510
72	MP0001293_anophthalmia	0.95297626
73	MP0000516_abnormal_urinary_system	0.94747478
74	MP0005367_renal/urinary_system_phenotyp	0.94747478
75	MP0002557_abnormal_social/conspecific_i	0.93342017
76	MP0002067_abnormal_sensory_capabilities	0.91566333
77	MP0003635_abnormal_synaptic_transmissio	0.88819574
78	MP0002938_white_spotting	0.88500568
79	MP0003137_abnormal_impulse_conducting	0.88253728
80	MP0003787_abnormal_imprinting	0.86532204
81	MP0004215_abnormal_myocardial_fiber	0.85511072
82	MP0002095_abnormal_skin_pigmentation	0.85389500
83	MP0000653_abnormal_sex_gland	0.84248849
84	MP0003122_maternal_imprinting	0.83325555
85	MP0002928_abnormal_bile_duct	0.82770527
86	MP0005670_abnormal_white_adipose	0.82716589
87	MP0004742_abnormal_vestibular_system	0.82159424
88	MP0002161_abnormal_fertility/fecundity	0.80671402
89	MP0001145_abnormal_male_reproductive	0.78164930
90	MP0001188_hyperpigmentation	0.77539893
91	MP0005084_abnormal_gallbladder_morpholo	0.75996103
92	MP0002229_neurodegeneration	0.75791454
93	MP0001270_distended_abdomen	0.74897890
94	MP0002063_abnormal_learning/memory/cond	0.74571344
95	MP0000538_abnormal_urinary_bladder	0.73354003
96	MP0010386_abnormal_urinary_bladder	0.72919815
97	MP0002069_abnormal_eating/drinking_beha	0.72508889
98	MP0000049_abnormal_middle_ear	0.72047232
99	MP0005391_vision/eye_phenotype	0.70844570
100	MP0002693_abnormal_pancreas_physiology	0.69941823

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.82888351
2	Colon cancer (HP:0003003)	3.62812966
3	Congenital primary aphakia (HP:0007707)	3.44241805
4	Gait imbalance (HP:0002141)	3.43391566
5	Pancreatic fibrosis (HP:0100732)	3.39723565
6	Nephronophthisis (HP:0000090)	3.38021820
7	Type II lissencephaly (HP:0007260)	3.32987465
8	Concave nail (HP:0001598)	3.29542956
9	True hermaphroditism (HP:0010459)	3.20608235
10	Nephrogenic diabetes insipidus (HP:0009806)	3.17642033
11	Neonatal respiratory distress (HP:0002643)	3.11790929
12	Pancreatic cysts (HP:0001737)	3.05376190
13	Chronic hepatic failure (HP:0100626)	3.03468419
14	Molar tooth sign on MRI (HP:0002419)	3.03362022
15	Abnormality of midbrain morphology (HP:0002418)	3.03362022
16	Progressive microcephaly (HP:0000253)	2.91752381
17	Attenuation of retinal blood vessels (HP:0007843)	2.90951926
18	Lipid accumulation in hepatocytes (HP:0006561)	2.86804050
19	Increased hepatocellular lipid droplets (HP:0006565)	2.84247884
20	Short tibia (HP:0005736)	2.81240369
21	Abnormal biliary tract physiology (HP:0012439)	2.79889296
22	Bile duct proliferation (HP:0001408)	2.79889296
23	Renal cortical cysts (HP:0000803)	2.74824211
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.74433170
25	Abnormality of the renal medulla (HP:0100957)	2.61518971
26	Retinal dysplasia (HP:0007973)	2.55081311
27	Large for gestational age (HP:0001520)	2.55051539
28	Congenital stationary night blindness (HP:0007642)	2.48662710
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48503509
30	Abnormal protein N-linked glycosylation (HP:0012347)	2.48503509
31	Abnormal protein glycosylation (HP:0012346)	2.48503509
32	Abnormal glycosylation (HP:0012345)	2.48503509
33	Genital tract atresia (HP:0001827)	2.48061582
34	Mitochondrial inheritance (HP:0001427)	2.44629820
35	Abnormality of the renal cortex (HP:0011035)	2.42518171
36	Increased CSF lactate (HP:0002490)	2.41755994
37	Hyperventilation (HP:0002883)	2.40768862
38	Vaginal atresia (HP:0000148)	2.37289152
39	Mesangial abnormality (HP:0001966)	2.35619861
40	Poor coordination (HP:0002370)	2.33941793
41	Inability to walk (HP:0002540)	2.27929529
42	Congenital, generalized hypertrichosis (HP:0004540)	2.27612678
43	Abnormality of macular pigmentation (HP:0008002)	2.27021687
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.24316392
45	Constricted visual fields (HP:0001133)	2.23400188
46	Hyperglycinuria (HP:0003108)	2.22716084
47	Congenital hepatic fibrosis (HP:0002612)	2.22355836
48	3-Methylglutaconic aciduria (HP:0003535)	2.21709545
49	Stomach cancer (HP:0012126)	2.20554744
50	Type I transferrin isoform profile (HP:0003642)	2.17949651
51	Severe muscular hypotonia (HP:0006829)	2.13384897
52	Aplasia/hypoplasia of the uterus (HP:0008684)	2.13187659
53	Hepatic necrosis (HP:0002605)	2.12978009
54	Hypothermia (HP:0002045)	2.12392744
55	Hypoplasia of the uterus (HP:0000013)	2.11255487
56	Abnormality of urine glucose concentration (HP:0011016)	2.10419619
57	Glycosuria (HP:0003076)	2.10419619
58	Renal Fanconi syndrome (HP:0001994)	2.09438524
59	Hyperglycinemia (HP:0002154)	2.05512662
60	Acute necrotizing encephalopathy (HP:0006965)	2.04961512
61	Reduced antithrombin III activity (HP:0001976)	2.04226692
62	Dyskinesia (HP:0100660)	2.03356390
63	Abolished electroretinogram (ERG) (HP:0000550)	2.02696242
64	Progressive macrocephaly (HP:0004481)	2.02476961
65	Fibular aplasia (HP:0002990)	2.02025346
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00879862
67	Abnormality of B cell number (HP:0010975)	1.98770692
68	Acute encephalopathy (HP:0006846)	1.96722822
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96510992
70	Ependymoma (HP:0002888)	1.96155544
71	Cystic liver disease (HP:0006706)	1.95746355
72	Hyperinsulinemic hypoglycemia (HP:0000825)	1.94553997
73	Thyroid-stimulating hormone excess (HP:0002925)	1.93917733
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92464043
75	Absent/shortened dynein arms (HP:0200106)	1.92464043
76	Hemiparesis (HP:0001269)	1.92403381
77	Postaxial foot polydactyly (HP:0001830)	1.92340774
78	Hepatocellular necrosis (HP:0001404)	1.92141521
79	Retinitis pigmentosa (HP:0000510)	1.89235136
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88465041
81	Broad foot (HP:0001769)	1.87776391
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.85975353
83	Abnormality of glycine metabolism (HP:0010895)	1.85975353
84	Disproportionate short-trunk short stature (HP:0003521)	1.85919849
85	Lethargy (HP:0001254)	1.84662076
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84138786
87	Dicarboxylic aciduria (HP:0003215)	1.84138786
88	Increased serum lactate (HP:0002151)	1.83166456
89	Hypoproteinemia (HP:0003075)	1.82922391
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81077119
91	Abnormality of alanine metabolism (HP:0010916)	1.81077119
92	Hyperalaninemia (HP:0003348)	1.81077119
93	Generalized aminoaciduria (HP:0002909)	1.80890341
94	Cerebellar dysplasia (HP:0007033)	1.80522641
95	Methylmalonic acidemia (HP:0002912)	1.80003654
96	Optic nerve hypoplasia (HP:0000609)	1.79824889
97	Ketosis (HP:0001946)	1.79200872
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78630535
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.78604960
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78341780

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	8.68468623
2	FRK	3.48441577
3	BCKDK	2.53662749
4	NUAK1	2.50696477
5	MAP3K4	2.33864334
6	CSNK1A1L	2.28826690
7	MAP2K7	2.26826032
8	CSNK1G3	2.23308412
9	PINK1	2.19659102
10	INSRR	2.11868798
11	BMPR1B	1.94329667
12	MAPK13	1.92740030
13	CSNK1G1	1.85135595
14	CSNK1G2	1.80110000
15	TAOK3	1.79471110
16	TXK	1.77632581
17	CDK19	1.73815933
18	MAPKAPK3	1.61900593
19	PDK2	1.60997727
20	ADRBK2	1.59404045
21	ZAK	1.59145088
22	VRK2	1.56270439
23	TESK2	1.46651180
24	GRK1	1.41270756
25	STK16	1.26501702
26	PNCK	1.24315428
27	PRKD3	1.23551113
28	WNK3	1.21924800
29	TRIM28	1.21508504
30	AKT3	1.19601420
31	PIK3CA	1.07938871
32	VRK1	1.07631319
33	BUB1	1.03879335
34	DYRK3	1.03716242
35	RAF1	1.00012393
36	NEK1	0.97530213
37	MAP2K4	0.97431124
38	TLK1	0.92659819
39	STK38L	0.87810384
40	EIF2AK3	0.85414833
41	PHKG1	0.83847752
42	PHKG2	0.83847752
43	MKNK1	0.77490679
44	PLK2	0.77428477
45	MAPK15	0.76833600
46	PRKCE	0.76760763
47	MAP4K1	0.76257372
48	CLK1	0.71408637
49	PIK3CG	0.68989699
50	OBSCN	0.68088694
51	CCNB1	0.67081775
52	CDK8	0.66568239
53	DAPK2	0.63603025
54	BCR	0.63326971
55	FLT3	0.63308701
56	MARK1	0.63048410
57	KIT	0.61846065
58	NTRK3	0.61664756
59	PLK4	0.61306689
60	SRPK1	0.60510572
61	LATS1	0.59574761
62	MAP3K6	0.58969311
63	RPS6KA5	0.58926246
64	PAK3	0.56169642
65	MARK3	0.55848477
66	MAP3K5	0.55340856
67	MKNK2	0.52166000
68	ITK	0.52150505
69	NEK2	0.47977013
70	PRKCQ	0.47209226
71	PLK3	0.45187103
72	RPS6KA4	0.45118066
73	CSNK1A1	0.44785392
74	TBK1	0.41905619
75	CDK9	0.39232164
76	PRKG2	0.38454334
77	PRKCG	0.37882865
78	DYRK2	0.37603262
79	PIM2	0.37597902
80	CDK3	0.36418624
81	MINK1	0.35794259
82	CAMKK2	0.35559729
83	ERBB3	0.34202691
84	PTK2B	0.33677455
85	EPHA4	0.33489183
86	PRKACA	0.33164378
87	ATR	0.32983215
88	CAMK2A	0.31924271
89	CSNK1D	0.31030328
90	TNIK	0.30105573
91	CSNK2A1	0.27764513
92	ATM	0.23819367
93	NME1	0.22563775
94	FER	0.22102777
95	TIE1	0.20964944
96	OXSR1	0.20813561
97	PRKCA	0.20387288
98	PRKCZ	0.20106122
99	IRAK2	0.20092796
100	PRKCI	0.19533594

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.11718738
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.66313297
3	Butanoate metabolism_Homo sapiens_hsa00650	3.52545737
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.66062149
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.57705239
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.41931355
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.15698795
8	Phototransduction_Homo sapiens_hsa04744	2.14249854
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11479408
10	Protein export_Homo sapiens_hsa03060	2.10476042
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.01207594
12	Parkinsons disease_Homo sapiens_hsa05012	1.85211075
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.84455744
14	RNA polymerase_Homo sapiens_hsa03020	1.80956681
15	Peroxisome_Homo sapiens_hsa04146	1.77648038
16	Propanoate metabolism_Homo sapiens_hsa00640	1.75578652
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70565014
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69921752
19	Olfactory transduction_Homo sapiens_hsa04740	1.56919432
20	Regulation of autophagy_Homo sapiens_hsa04140	1.54504935
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.52981753
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52331392
23	Nicotine addiction_Homo sapiens_hsa05033	1.49404340
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49166336
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.49094114
26	Proteasome_Homo sapiens_hsa03050	1.44968772
27	Basal transcription factors_Homo sapiens_hsa03022	1.43882447
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31811113
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31639731
30	Base excision repair_Homo sapiens_hsa03410	1.31548856
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.31507043
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28142710
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.27858976
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23387258
35	One carbon pool by folate_Homo sapiens_hsa00670	1.21590282
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21540645
37	Taste transduction_Homo sapiens_hsa04742	1.19976722
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19784228
39	RNA degradation_Homo sapiens_hsa03018	1.18253791
40	RNA transport_Homo sapiens_hsa03013	1.15967066
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11225671
42	Alzheimers disease_Homo sapiens_hsa05010	1.11194744
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11112222
44	Huntingtons disease_Homo sapiens_hsa05016	1.07967551
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.06694469
46	Homologous recombination_Homo sapiens_hsa03440	1.05394190
47	Collecting duct acid secretion_Homo sapiens_hsa04966	1.00966122
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99476509
49	Purine metabolism_Homo sapiens_hsa00230	0.94561265
50	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.94278899
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89718990
52	Sulfur metabolism_Homo sapiens_hsa00920	0.88652212
53	GABAergic synapse_Homo sapiens_hsa04727	0.88374890
54	Metabolic pathways_Homo sapiens_hsa01100	0.85945660
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84169857
56	ABC transporters_Homo sapiens_hsa02010	0.80534637
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78961280
58	Caffeine metabolism_Homo sapiens_hsa00232	0.77869099
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.76281864
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76164860
61	Glutathione metabolism_Homo sapiens_hsa00480	0.75328678
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74962577
63	Arginine biosynthesis_Homo sapiens_hsa00220	0.74144225
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.74059664
65	Circadian entrainment_Homo sapiens_hsa04713	0.73532741
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70730854
67	Morphine addiction_Homo sapiens_hsa05032	0.69306140
68	Fatty acid elongation_Homo sapiens_hsa00062	0.68597944
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68262825
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67801118
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64061710
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63086098
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.63073701
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.56004963
75	Salivary secretion_Homo sapiens_hsa04970	0.55921423
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55679676
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55516481
78	Insulin secretion_Homo sapiens_hsa04911	0.55378535
79	Spliceosome_Homo sapiens_hsa03040	0.53595808
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53470707
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.52500898
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.48057664
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.43744573
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43040045
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40685878
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.39315702
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39100397
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38876750
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.37508436
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36096130
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.35751002
92	Cocaine addiction_Homo sapiens_hsa05030	0.33872049
93	Retinol metabolism_Homo sapiens_hsa00830	0.33066702
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32519453
95	Carbon metabolism_Homo sapiens_hsa01200	0.32302432
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.32169375
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.32104175
98	Fatty acid degradation_Homo sapiens_hsa00071	0.31978143
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31104649
100	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30842197

SPDYE12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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