ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maintenance of gastrointestinal epithelium (GO:0030277)	8.29164486
2	protein targeting to Golgi (GO:0000042)	7.88837886
3	establishment of protein localization to Golgi (GO:0072600)	7.78231425
4	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.50243342
5	epithelial structure maintenance (GO:0010669)	6.60470450
6	protein localization to Golgi apparatus (GO:0034067)	5.96659767
7	fucose catabolic process (GO:0019317)	5.60025435
8	L-fucose metabolic process (GO:0042354)	5.60025435
9	L-fucose catabolic process (GO:0042355)	5.60025435
10	DNA double-strand break processing (GO:0000729)	5.44409621
11	regulation of ARF GTPase activity (GO:0032312)	4.98108668
12	intra-Golgi vesicle-mediated transport (GO:0006891)	4.64259304
13	regulation of glucokinase activity (GO:0033131)	4.39738019
14	regulation of hexokinase activity (GO:1903299)	4.39738019
15	vocalization behavior (GO:0071625)	4.39609105
16	O-glycan processing (GO:0016266)	4.37338908
17	mismatch repair (GO:0006298)	4.03839705
18	sulfate transmembrane transport (GO:1902358)	4.00163369
19	fucosylation (GO:0036065)	3.81851401
20	nephron tubule morphogenesis (GO:0072078)	3.66378244
21	nephron epithelium morphogenesis (GO:0072088)	3.66378244
22	rRNA catabolic process (GO:0016075)	3.66192991
23	positive regulation of granulocyte differentiation (GO:0030854)	3.62603199
24	histone H3-K4 trimethylation (GO:0080182)	3.59091587
25	sulfate transport (GO:0008272)	3.46591983
26	histone H3-K9 methylation (GO:0051567)	3.34138061
27	histone H2A acetylation (GO:0043968)	3.27761441
28	histone H3-K4 methylation (GO:0051568)	3.27680886
29	protein O-linked glycosylation (GO:0006493)	3.19560395
30	regulation of G0 to G1 transition (GO:0070316)	3.18652780
31	renal tubule morphogenesis (GO:0061333)	3.18211699
32	photoreceptor cell maintenance (GO:0045494)	3.16783839
33	auditory receptor cell differentiation (GO:0042491)	3.16166455
34	peptidyl-lysine trimethylation (GO:0018023)	3.13158458
35	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.10447919
36	nonmotile primary cilium assembly (GO:0035058)	3.00268042
37	microtubule nucleation (GO:0007020)	2.94790570
38	negative regulation of myotube differentiation (GO:0010832)	2.93458307
39	histone H3-K9 modification (GO:0061647)	2.88195032
40	cilium or flagellum-dependent cell motility (GO:0001539)	2.87688705
41	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.87259406
42	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.86946550
43	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.86946550
44	mannosylation (GO:0097502)	2.83177095
45	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.82811376
46	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.82811376
47	regulation of translation, ncRNA-mediated (GO:0045974)	2.82811376
48	glial cell proliferation (GO:0014009)	2.79418276
49	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.71783306
50	positive regulation of action potential (GO:0045760)	2.71438430
51	replication fork processing (GO:0031297)	2.69765465
52	neural tube formation (GO:0001841)	2.69490621
53	regulation of MHC class I biosynthetic process (GO:0045343)	2.69232760
54	auditory behavior (GO:0031223)	2.68839258
55	dendritic cell chemotaxis (GO:0002407)	2.68235267
56	centriole replication (GO:0007099)	2.67735890
57	negative regulation of multicellular organism growth (GO:0040015)	2.64515381
58	axoneme assembly (GO:0035082)	2.64057899
59	histone lysine methylation (GO:0034968)	2.63824764
60	response to vitamin A (GO:0033189)	2.63674366
61	N-terminal protein amino acid acetylation (GO:0006474)	2.62879146
62	male sex determination (GO:0030238)	2.61950803
63	positive regulation of CREB transcription factor activity (GO:0032793)	2.61646462
64	regulation of cilium movement (GO:0003352)	2.56823652
65	DNA alkylation (GO:0006305)	2.56724572
66	DNA methylation (GO:0006306)	2.56724572
67	double-strand break repair via homologous recombination (GO:0000724)	2.55294875
68	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.55019827
69	regulation of telomere maintenance (GO:0032204)	2.54840317
70	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.54083657
71	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.54083657
72	recombinational repair (GO:0000725)	2.54025806
73	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.53360457
74	gamma-aminobutyric acid transport (GO:0015812)	2.51935430
75	peptidyl-lysine methylation (GO:0018022)	2.51055497
76	muscle atrophy (GO:0014889)	2.49848168
77	photoreceptor cell development (GO:0042461)	2.47560024
78	positive regulation by host of viral transcription (GO:0043923)	2.45986174
79	growth hormone secretion (GO:0030252)	2.44106237
80	multicellular organism reproduction (GO:0032504)	2.42191248
81	positive regulation of mRNA catabolic process (GO:0061014)	2.41506150
82	retinal cone cell development (GO:0046549)	2.41358484
83	inner ear receptor stereocilium organization (GO:0060122)	2.39833041
84	DNA integration (GO:0015074)	2.39697831
85	appendage development (GO:0048736)	2.39409165
86	limb development (GO:0060173)	2.39409165
87	positive regulation of organelle assembly (GO:1902117)	2.39362331
88	histone H3-K9 demethylation (GO:0033169)	2.39107787
89	brain morphogenesis (GO:0048854)	2.39058384
90	cellular response to epidermal growth factor stimulus (GO:0071364)	2.38627060
91	eye photoreceptor cell development (GO:0042462)	2.37502734
92	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.37187347
93	positive regulation of growth hormone secretion (GO:0060124)	2.36673242
94	striated muscle atrophy (GO:0014891)	2.36569714
95	cilium morphogenesis (GO:0060271)	2.36424597
96	intraciliary transport (GO:0042073)	2.36170360
97	protein polyglutamylation (GO:0018095)	2.35104737
98	cytoplasmic mRNA processing body assembly (GO:0033962)	2.34665752
99	tachykinin receptor signaling pathway (GO:0007217)	2.33786691
100	cilium organization (GO:0044782)	2.33445532

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.67464402
2	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	4.40100476
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.76943999
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.32078607
5	DROSHA_22980978_ChIP-Seq_HELA_Human	3.22214191
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.21754754
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.04565895
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02390489
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.73290046
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.64757673
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.53635288
12	VDR_22108803_ChIP-Seq_LS180_Human	2.39808933
13	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.36368337
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.24595043
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.14291444
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.06437800
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06396146
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.88575449
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87508987
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.85854710
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80342937
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.76867273
23	FUS_26573619_Chip-Seq_HEK293_Human	1.71489925
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69207919
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.69207919
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.61713010
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61002375
28	STAT3_23295773_ChIP-Seq_U87_Human	1.58881990
29	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.58539239
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.55875886
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.54104717
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53106823
33	TCF4_23295773_ChIP-Seq_U87_Human	1.50630891
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49396645
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48110849
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46818324
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44931678
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43783588
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40323647
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.37472868
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36553420
42	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.35368565
43	EWS_26573619_Chip-Seq_HEK293_Human	1.34877917
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33185138
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32876960
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32506242
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28085650
48	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27175324
49	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.26391221
50	AR_25329375_ChIP-Seq_VCAP_Human	1.25948201
51	P300_19829295_ChIP-Seq_ESCs_Human	1.23288957
52	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.22019285
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21549278
54	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16446553
55	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15002895
56	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.12652931
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12368009
58	CDX2_22108803_ChIP-Seq_LS180_Human	1.11597447
59	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10015842
60	GATA3_26560356_Chip-Seq_TH2_Human	1.09848252
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.09475142
62	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08663389
63	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.08267129
64	ERA_21632823_ChIP-Seq_H3396_Human	1.08033143
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06779625
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.05662873
67	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05625141
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05230967
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05230967
70	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04363795
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03354808
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03002168
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02788598
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.02762371
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02080049
76	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02021813
77	SCL_19346495_ChIP-Seq_HPC-7_Human	1.01234482
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00790339
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00495287
80	RXR_22108803_ChIP-Seq_LS180_Human	1.00342164
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99661129
82	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.99486210
83	TP53_16413492_ChIP-PET_HCT116_Human	0.98496549
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98031351
85	NFYA_21822215_ChIP-Seq_K562_Human	0.96364168
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96038595
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95991326
88	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95571860
89	TBL1_22424771_ChIP-Seq_293T_Human	0.94794898
90	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94333013
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94249101
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92621612
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91517995
94	NCOR_22424771_ChIP-Seq_293T_Human	0.91349066
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91035185
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90888834
97	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90858099
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90312625
99	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90310283
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87897459

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	5.31397030
2	MP0000465_gastrointestinal_hemorrhage	4.92491819
3	MP0004043_abnormal_pH_regulation	3.18488990
4	MP0010386_abnormal_urinary_bladder	2.94832579
5	MP0003866_abnormal_defecation	2.80583755
6	MP0005551_abnormal_eye_electrophysiolog	2.73032385
7	MP0001666_abnormal_nutrient_absorption	2.33041742
8	MP0001664_abnormal_digestion	2.19724798
9	MP0001501_abnormal_sleep_pattern	2.16608491
10	MP0008058_abnormal_DNA_repair	2.12436230
11	MP0005310_abnormal_salivary_gland	2.06009623
12	MP0002102_abnormal_ear_morphology	1.92070861
13	MP0001485_abnormal_pinna_reflex	1.91901866
14	MP0003045_fibrosis	1.91171364
15	MP0004145_abnormal_muscle_electrophysio	1.89937079
16	MP0008995_early_reproductive_senescence	1.89585976
17	MP0000538_abnormal_urinary_bladder	1.87581719
18	MP0010094_abnormal_chromosome_stability	1.74257321
19	MP0005646_abnormal_pituitary_gland	1.73646742
20	MP0000462_abnormal_digestive_system	1.67475441
21	MP0003252_abnormal_bile_duct	1.59640656
22	MP0002735_abnormal_chemical_nociception	1.55946341
23	MP0000569_abnormal_digit_pigmentation	1.55851564
24	MP0001270_distended_abdomen	1.44387489
25	MP0002396_abnormal_hematopoietic_system	1.43253155
26	MP0000566_synostosis	1.42349571
27	MP0003879_abnormal_hair_cell	1.39254468
28	MP0002751_abnormal_autonomic_nervous	1.38495311
29	MP0005503_abnormal_tendon_morphology	1.37548417
30	MP0002822_catalepsy	1.37170689
31	MP0000383_abnormal_hair_follicle	1.35685422
32	MP0000579_abnormal_nail_morphology	1.31291203
33	MP0005645_abnormal_hypothalamus_physiol	1.29439550
34	MP0005253_abnormal_eye_physiology	1.28493030
35	MP0003646_muscle_fatigue	1.28204570
36	MP0000631_abnormal_neuroendocrine_gland	1.26462859
37	MP0002928_abnormal_bile_duct	1.23006612
38	MP0000470_abnormal_stomach_morphology	1.17518519
39	MP0008438_abnormal_cutaneous_collagen	1.15667674
40	MP0008961_abnormal_basal_metabolism	1.14588130
41	MP0010307_abnormal_tumor_latency	1.07803404
42	MP0001984_abnormal_olfaction	1.07622001
43	MP0001765_abnormal_ion_homeostasis	1.07445473
44	MP0003698_abnormal_male_reproductive	1.07273654
45	MP0001963_abnormal_hearing_physiology	1.05778946
46	MP0003385_abnormal_body_wall	1.02370740
47	MP0005381_digestive/alimentary_phenotyp	1.02223567
48	MP0006072_abnormal_retinal_apoptosis	1.01655895
49	MP0004142_abnormal_muscle_tone	1.01601356
50	MP0001486_abnormal_startle_reflex	1.01246237
51	MP0000026_abnormal_inner_ear	1.00289050
52	MP0009697_abnormal_copulation	1.00189133
53	MP0005257_abnormal_intraocular_pressure	0.99321879
54	MP0004084_abnormal_cardiac_muscle	0.98938240
55	MP0008877_abnormal_DNA_methylation	0.97327079
56	MP0005448_abnormal_energy_balance	0.97193144
57	MP0002272_abnormal_nervous_system	0.96496652
58	MP0001929_abnormal_gametogenesis	0.95588461
59	MP0002098_abnormal_vibrissa_morphology	0.95580726
60	MP0008872_abnormal_physiological_respon	0.94551244
61	MP0000427_abnormal_hair_cycle	0.93869635
62	MP0005275_abnormal_skin_tensile	0.91224776
63	MP0002168_other_aberrant_phenotype	0.90580549
64	MP0004133_heterotaxia	0.90358903
65	MP0009384_cardiac_valve_regurgitation	0.90276019
66	MP0002210_abnormal_sex_determination	0.88636657
67	MP0010155_abnormal_intestine_physiology	0.88017491
68	MP0003786_premature_aging	0.87180394
69	MP0004742_abnormal_vestibular_system	0.86836953
70	MP0005386_behavior/neurological_phenoty	0.86620297
71	MP0004924_abnormal_behavior	0.86620297
72	MP0001663_abnormal_digestive_system	0.84593666
73	MP0002229_neurodegeneration	0.84502294
74	MP0001502_abnormal_circadian_rhythm	0.81668416
75	MP0005377_hearing/vestibular/ear_phenot	0.80685845
76	MP0003878_abnormal_ear_physiology	0.80685845
77	MP0002108_abnormal_muscle_morphology	0.80484566
78	MP0005083_abnormal_biliary_tract	0.79865210
79	MP0000432_abnormal_head_morphology	0.79687195
80	MP0000230_abnormal_systemic_arterial	0.77266167
81	MP0002752_abnormal_somatic_nervous	0.76803346
82	MP0004147_increased_porphyrin_level	0.75833384
83	MP0003195_calcinosis	0.75529096
84	MP0001756_abnormal_urination	0.74672037
85	MP0002557_abnormal_social/conspecific_i	0.73861509
86	MP0009046_muscle_twitch	0.73156989
87	MP0003763_abnormal_thymus_physiology	0.71737469
88	MP0000653_abnormal_sex_gland	0.71656719
89	MP0005076_abnormal_cell_differentiation	0.70285365
90	MP0002233_abnormal_nose_morphology	0.69911869
91	MP0003943_abnormal_hepatobiliary_system	0.67609835
92	MP0002111_abnormal_tail_morphology	0.67288385
93	MP0004036_abnormal_muscle_relaxation	0.67060093
94	MP0002109_abnormal_limb_morphology	0.66147241
95	MP0009278_abnormal_bone_marrow	0.64075572
96	MP0002970_abnormal_white_adipose	0.63212042
97	MP0001119_abnormal_female_reproductive	0.63169182
98	MP0000647_abnormal_sebaceous_gland	0.62865848
99	MP0002095_abnormal_skin_pigmentation	0.62780579
100	MP0005395_other_phenotype	0.62019693

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the fingertips (HP:0001211)	4.06881898
2	Abnormality of dentin (HP:0010299)	3.48396855
3	Ectopic kidney (HP:0000086)	3.28109081
4	Abnormality of the columella (HP:0009929)	3.24840425
5	Duplicated collecting system (HP:0000081)	3.23411124
6	Long eyelashes (HP:0000527)	3.23221198
7	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.13953897
8	Tubulointerstitial nephritis (HP:0001970)	3.13829153
9	Cystic liver disease (HP:0006706)	3.01126395
10	Urethral obstruction (HP:0000796)	2.97408141
11	Abnormality of DNA repair (HP:0003254)	2.92927808
12	Cerebellar dysplasia (HP:0007033)	2.86053950
13	Chromsome breakage (HP:0040012)	2.84416207
14	Spinal muscular atrophy (HP:0007269)	2.82942825
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.81040402
16	Thyroid-stimulating hormone excess (HP:0002925)	2.80579209
17	Abnormality of the renal collecting system (HP:0004742)	2.76641569
18	Pili torti (HP:0003777)	2.74067522
19	Abnormality of the renal cortex (HP:0011035)	2.65964712
20	Gaze-evoked nystagmus (HP:0000640)	2.64178433
21	Severe combined immunodeficiency (HP:0004430)	2.63816778
22	Abnormal hair whorl (HP:0010721)	2.61054445
23	Pancreatic cysts (HP:0001737)	2.60800400
24	Progressive cerebellar ataxia (HP:0002073)	2.56642134
25	Abnormality of the nasal septum (HP:0000419)	2.54165546
26	Ulnar claw (HP:0001178)	2.53724048
27	Self-mutilation (HP:0000742)	2.51954987
28	Morphological abnormality of the middle ear (HP:0008609)	2.51744630
29	True hermaphroditism (HP:0010459)	2.51324971
30	Abnormality of the renal medulla (HP:0100957)	2.50905297
31	Depressed nasal tip (HP:0000437)	2.50294194
32	Ependymoma (HP:0002888)	2.49752424
33	Abnormality of the preputium (HP:0100587)	2.49236942
34	Genetic anticipation (HP:0003743)	2.48557062
35	Abnormality of the ileum (HP:0001549)	2.48257415
36	Chronic hepatic failure (HP:0100626)	2.47470053
37	Reticulocytopenia (HP:0001896)	2.43669724
38	Thyroiditis (HP:0100646)	2.42600639
39	Nephronophthisis (HP:0000090)	2.42380744
40	Abnormality of lateral ventricle (HP:0030047)	2.39349612
41	Hyperkalemia (HP:0002153)	2.37035970
42	Delayed CNS myelination (HP:0002188)	2.30578409
43	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.27881354
44	Abnormality of chromosome stability (HP:0003220)	2.27477119
45	Meckel diverticulum (HP:0002245)	2.26126028
46	Pancreatic fibrosis (HP:0100732)	2.25756239
47	Spondylolisthesis (HP:0003302)	2.24909846
48	Broad-based gait (HP:0002136)	2.22851169
49	Renal cortical cysts (HP:0000803)	2.22795231
50	Clubbing of toes (HP:0100760)	2.21796872
51	Congenital sensorineural hearing impairment (HP:0008527)	2.18391644
52	Abnormal biliary tract physiology (HP:0012439)	2.18210123
53	Bile duct proliferation (HP:0001408)	2.18210123
54	Hypoplastic ischia (HP:0003175)	2.17937481
55	Type II lissencephaly (HP:0007260)	2.17767657
56	Poor coordination (HP:0002370)	2.15267675
57	Keratoconus (HP:0000563)	2.15161119
58	Increased corneal curvature (HP:0100692)	2.15161119
59	Glioma (HP:0009733)	2.14138518
60	Impulsivity (HP:0100710)	2.12551045
61	Prominent nose (HP:0000448)	2.10882940
62	Abnormality of the astrocytes (HP:0100707)	2.08974383
63	Astrocytoma (HP:0009592)	2.08974383
64	Mild short stature (HP:0003502)	2.08419483
65	Heterotopia (HP:0002282)	2.08176351
66	Neonatal respiratory distress (HP:0002643)	2.08165642
67	Abnormality of the aortic arch (HP:0012303)	2.07963304
68	Abnormality of the carotid arteries (HP:0005344)	2.06242520
69	Hypoplastic iliac wings (HP:0002866)	2.04282539
70	Abnormality of chloride homeostasis (HP:0011422)	2.02595464
71	IgM deficiency (HP:0002850)	2.02224093
72	Enlarged epiphyses (HP:0010580)	2.00941902
73	Long clavicles (HP:0000890)	2.00516402
74	Palpebral edema (HP:0100540)	2.00269670
75	Medial flaring of the eyebrow (HP:0010747)	1.96532490
76	Narrow palate (HP:0000189)	1.95268492
77	Neonatal short-limb short stature (HP:0008921)	1.92720331
78	Broad face (HP:0000283)	1.91844421
79	Abnormal protein glycosylation (HP:0012346)	1.91671760
80	Abnormal glycosylation (HP:0012345)	1.91671760
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91671760
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.91671760
83	Sparse scalp hair (HP:0002209)	1.89155035
84	Volvulus (HP:0002580)	1.87167841
85	Truncal obesity (HP:0001956)	1.86270840
86	Aortic dissection (HP:0002647)	1.86200344
87	Villous atrophy (HP:0011473)	1.84727830
88	Abnormality of small intestinal villus morphology (HP:0011472)	1.84727830
89	Congenital stationary night blindness (HP:0007642)	1.83818209
90	Sloping forehead (HP:0000340)	1.83738768
91	Abnormal number of erythroid precursors (HP:0012131)	1.82564763
92	Peritonitis (HP:0002586)	1.81263204
93	Premature skin wrinkling (HP:0100678)	1.81058888
94	Abnormality of the incisor (HP:0000676)	1.80271975
95	Bulbous nose (HP:0000414)	1.80117559
96	Stomach cancer (HP:0012126)	1.78545711
97	Congenital primary aphakia (HP:0007707)	1.77359936
98	Congenital hepatic fibrosis (HP:0002612)	1.76562287
99	Molar tooth sign on MRI (HP:0002419)	1.75808727
100	Abnormality of midbrain morphology (HP:0002418)	1.75808727

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	5.00345091
2	MST1R	3.99471265
3	BMPR1B	3.21858426
4	MAP4K2	3.03288475
5	FRK	2.88315355
6	MET	2.70042379
7	NME1	2.69590815
8	INSRR	2.35419682
9	CDK12	2.31863706
10	TAOK3	2.21675384
11	NEK2	2.02339708
12	STK39	1.90294049
13	WNK1	1.88646876
14	ACVR1B	1.83688551
15	MUSK	1.80141711
16	PINK1	1.79857255
17	CAMK1D	1.77795482
18	AKT3	1.77737250
19	BLK	1.64737417
20	CAMK1G	1.63066556
21	MAP3K4	1.52269598
22	ADRBK2	1.45467500
23	TNK2	1.37359428
24	EPHA3	1.30786296
25	MKNK1	1.27674862
26	SIK2	1.25996057
27	BCKDK	1.21857239
28	ERBB2	1.18431234
29	TGFBR1	1.17786285
30	ZAK	1.14530594
31	KIT	1.12611105
32	MAPK13	1.12001790
33	FGFR2	1.10860767
34	WNK3	1.09760414
35	LMTK2	1.06975964
36	CSNK1A1L	1.04395342
37	CASK	0.97289555
38	MARK3	0.97121478
39	NLK	0.96708090
40	CHUK	0.94216668
41	ATR	0.90732662
42	CDC42BPA	0.89777865
43	NUAK1	0.87622825
44	TNIK	0.86392341
45	OBSCN	0.82991216
46	CAMK4	0.82758636
47	MAP3K7	0.82513145
48	MKNK2	0.80951889
49	CAMK1	0.73905823
50	PAK3	0.73722949
51	SGK2	0.72919596
52	PRKCH	0.72825340
53	CDK3	0.70366666
54	GRK1	0.69906589
55	PLK4	0.67845110
56	PNCK	0.67269394
57	OXSR1	0.65791595
58	CSNK1G1	0.61562777
59	BRD4	0.57455804
60	FES	0.56243526
61	MTOR	0.55696543
62	CSNK1G3	0.55559105
63	MAPK15	0.54196188
64	PRKD2	0.53244809
65	PDK2	0.52905001
66	MAP2K7	0.52328674
67	FLT3	0.52187345
68	ATM	0.50566796
69	MAPK1	0.49851162
70	LATS1	0.47583227
71	PKN2	0.47298185
72	BCR	0.45380065
73	MAPK11	0.44829256
74	SGK494	0.44789667
75	SGK223	0.44789667
76	MAPK3	0.44723747
77	RPS6KA5	0.43679767
78	ADRBK1	0.43672782
79	CSNK1D	0.42832291
80	PIK3CA	0.41060750
81	RPS6KA4	0.40181140
82	GSK3B	0.40006969
83	SGK1	0.39706786
84	IKBKB	0.39255310
85	PRKCE	0.39226385
86	TEC	0.38587042
87	PRKAA1	0.38550564
88	CSNK1A1	0.38226207
89	PDGFRB	0.37542186
90	CDK1	0.36719603
91	VRK1	0.36085365
92	CSF1R	0.35802988
93	MARK2	0.35786420
94	PRKAA2	0.35615670
95	MAP2K6	0.35367324
96	CDK2	0.34884221
97	STK38	0.34393912
98	MAPKAPK3	0.34026411
99	STK38L	0.33313832
100	TIE1	0.32265138

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	4.15544738
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.62051221
3	RNA polymerase_Homo sapiens_hsa03020	3.23302436
4	Oocyte meiosis_Homo sapiens_hsa04114	3.14226325
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.00749238
6	Phototransduction_Homo sapiens_hsa04744	2.80515818
7	Taste transduction_Homo sapiens_hsa04742	2.41821839
8	Lysine degradation_Homo sapiens_hsa00310	2.37108044
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.22709604
10	Homologous recombination_Homo sapiens_hsa03440	2.19617941
11	Olfactory transduction_Homo sapiens_hsa04740	2.13576992
12	ABC transporters_Homo sapiens_hsa02010	2.05891584
13	Primary immunodeficiency_Homo sapiens_hsa05340	2.02337216
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94018293
15	Butanoate metabolism_Homo sapiens_hsa00650	1.78708864
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.76309402
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.76032092
18	Salivary secretion_Homo sapiens_hsa04970	1.75126023
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68825761
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68613332
21	Protein digestion and absorption_Homo sapiens_hsa04974	1.68405620
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46861174
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.44711226
24	Basal transcription factors_Homo sapiens_hsa03022	1.41823196
25	RNA transport_Homo sapiens_hsa03013	1.41074810
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39395568
27	Propanoate metabolism_Homo sapiens_hsa00640	1.39360079
28	Base excision repair_Homo sapiens_hsa03410	1.37607982
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37089803
30	RNA degradation_Homo sapiens_hsa03018	1.31170522
31	One carbon pool by folate_Homo sapiens_hsa00670	1.28076827
32	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.27344480
33	Purine metabolism_Homo sapiens_hsa00230	1.17780398
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.16627479
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.08605825
36	Pancreatic secretion_Homo sapiens_hsa04972	1.05183755
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.05020574
38	Circadian rhythm_Homo sapiens_hsa04710	1.04531077
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.01246712
40	Circadian entrainment_Homo sapiens_hsa04713	1.00892208
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00161621
42	Glutamatergic synapse_Homo sapiens_hsa04724	0.99502848
43	Nicotine addiction_Homo sapiens_hsa05033	0.97722549
44	Notch signaling pathway_Homo sapiens_hsa04330	0.97613009
45	Insulin secretion_Homo sapiens_hsa04911	0.96893263
46	ECM-receptor interaction_Homo sapiens_hsa04512	0.94453243
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.93330774
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89881449
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89444675
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87933496
51	Mineral absorption_Homo sapiens_hsa04978	0.80245752
52	Other glycan degradation_Homo sapiens_hsa00511	0.79227535
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72075274
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70706215
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70644328
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67157815
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66630836
58	Huntingtons disease_Homo sapiens_hsa05016	0.66629721
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.65282536
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.64816096
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.60590461
62	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.57718215
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57596196
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.56651293
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.56065188
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55885211
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55087459
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53975992
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51509516
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51108101
71	Peroxisome_Homo sapiens_hsa04146	0.50014882
72	Serotonergic synapse_Homo sapiens_hsa04726	0.48869514
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47862306
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.46766703
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45992233
76	Gastric acid secretion_Homo sapiens_hsa04971	0.45847039
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45646715
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.45053650
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43405357
80	Cholinergic synapse_Homo sapiens_hsa04725	0.42122284
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39181016
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36518412
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36443261
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.34092344
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.32886678
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32845635
87	GABAergic synapse_Homo sapiens_hsa04727	0.32697281
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.32256671
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32144960
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31994354
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31988727
92	Morphine addiction_Homo sapiens_hsa05032	0.31402855
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.31106918
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30978707
95	Herpes simplex infection_Homo sapiens_hsa05168	0.27817210
96	Caffeine metabolism_Homo sapiens_hsa00232	0.27721066
97	Platelet activation_Homo sapiens_hsa04611	0.27698184
98	Renin secretion_Homo sapiens_hsa04924	0.27160833
99	Long-term depression_Homo sapiens_hsa04730	0.26870738
100	Regulation of autophagy_Homo sapiens_hsa04140	0.26765491

SPDYE15P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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