SPDYE16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation, ncRNA-mediated (GO:0040033)4.71901666
2regulation of translation, ncRNA-mediated (GO:0045974)4.71901666
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.71901666
4establishment of protein localization to Golgi (GO:0072600)4.70900229
5histone H3-K4 trimethylation (GO:0080182)4.30852387
6protein targeting to Golgi (GO:0000042)3.85010883
7neural tube formation (GO:0001841)3.78260664
8retrograde transport, vesicle recycling within Golgi (GO:0000301)3.71205384
9detection of light stimulus involved in sensory perception (GO:0050962)3.55529696
10detection of light stimulus involved in visual perception (GO:0050908)3.55529696
11indolalkylamine catabolic process (GO:0046218)3.47615628
12tryptophan catabolic process (GO:0006569)3.47615628
13indole-containing compound catabolic process (GO:0042436)3.47615628
14positive regulation of mRNA catabolic process (GO:0061014)3.43775055
15kynurenine metabolic process (GO:0070189)3.43639591
16tryptophan metabolic process (GO:0006568)3.42883422
17cellular response to ethanol (GO:0071361)3.39509424
18regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.38163365
19positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.38163365
20fucose catabolic process (GO:0019317)3.37882753
21L-fucose metabolic process (GO:0042354)3.37882753
22L-fucose catabolic process (GO:0042355)3.37882753
23positive regulation of granulocyte differentiation (GO:0030854)3.36751096
24positive regulation of CREB transcription factor activity (GO:0032793)3.27656957
25response to pheromone (GO:0019236)3.26954414
26positive regulation of developmental pigmentation (GO:0048087)3.25080780
27rRNA catabolic process (GO:0016075)3.21628559
28interkinetic nuclear migration (GO:0022027)3.19434232
29protein K48-linked deubiquitination (GO:0071108)3.19132026
30regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.16846763
31positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.16846763
32protein localization to Golgi apparatus (GO:0034067)3.15084459
33indolalkylamine metabolic process (GO:0006586)3.09125849
34histone H3-K4 methylation (GO:0051568)3.08595220
35negative regulation of cAMP-mediated signaling (GO:0043951)3.08390125
36histone H3-K9 methylation (GO:0051567)3.08295597
37protein K11-linked deubiquitination (GO:0035871)3.04758066
38behavioral response to nicotine (GO:0035095)3.04655519
39histone mRNA catabolic process (GO:0071044)3.04210338
40cellular response to exogenous dsRNA (GO:0071360)3.03917849
41peptidyl-lysine trimethylation (GO:0018023)3.03608175
42histone lysine methylation (GO:0034968)3.00209030
43cAMP catabolic process (GO:0006198)2.98936883
44regulation of mRNA catabolic process (GO:0061013)2.95803119
45protein polyglutamylation (GO:0018095)2.91578599
46protein K63-linked deubiquitination (GO:0070536)2.88404557
47regulation of MHC class I biosynthetic process (GO:0045343)2.88045513
48cilium or flagellum-dependent cell motility (GO:0001539)2.83769678
49histone H3-K9 modification (GO:0061647)2.83701923
50peptidyl-lysine methylation (GO:0018022)2.81470333
51positive T cell selection (GO:0043368)2.79845939
52negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74992730
53preassembly of GPI anchor in ER membrane (GO:0016254)2.70127822
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68977822
55cyclic nucleotide catabolic process (GO:0009214)2.66501771
56axoneme assembly (GO:0035082)2.66211577
57regulation of germinal center formation (GO:0002634)2.64748962
58NAD biosynthetic process (GO:0009435)2.64703916
59negative T cell selection (GO:0043383)2.62520336
60negative thymic T cell selection (GO:0045060)2.59344671
61protein localization to cilium (GO:0061512)2.56329475
62snRNA transcription (GO:0009301)2.56293329
63positive thymic T cell selection (GO:0045059)2.52101516
64RNA destabilization (GO:0050779)2.51472240
65regulation of B cell receptor signaling pathway (GO:0050855)2.49457926
66multicellular organism reproduction (GO:0032504)2.48872757
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48790763
68positive regulation of mRNA metabolic process (GO:1903313)2.47502084
69regulation of pigment cell differentiation (GO:0050932)2.47180255
70activated T cell proliferation (GO:0050798)2.46795965
71monoubiquitinated protein deubiquitination (GO:0035520)2.45915935
72Golgi to endosome transport (GO:0006895)2.43484277
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.41103456
74photoreceptor cell maintenance (GO:0045494)2.38753574
75regulation of gamma-delta T cell differentiation (GO:0045586)2.38247126
76DNA deamination (GO:0045006)2.37839086
77cellular ketone body metabolic process (GO:0046950)2.34832303
78negative regulation of mast cell activation (GO:0033004)2.34789743
79cornea development in camera-type eye (GO:0061303)2.34046837
80positive regulation of mRNA 3-end processing (GO:0031442)2.33303301
81B cell receptor signaling pathway (GO:0050853)2.31514000
82regulation of establishment of cell polarity (GO:2000114)2.30938525
83embryonic hemopoiesis (GO:0035162)2.30842091
84positive regulation of defense response to virus by host (GO:0002230)2.30421073
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.29629013
86growth hormone receptor signaling pathway (GO:0060396)2.28712359
87histone methylation (GO:0016571)2.27224941
88regulation of gamma-delta T cell activation (GO:0046643)2.26107211
89positive regulation of gamma-delta T cell activation (GO:0046645)2.26006695
90double-strand break repair via homologous recombination (GO:0000724)2.24440197
91DNA methylation (GO:0006306)2.23401048
92DNA alkylation (GO:0006305)2.23401048
93phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.21950220
94DNA demethylation (GO:0080111)2.21866278
95oxidative demethylation (GO:0070989)2.21623944
96regulation of granulocyte differentiation (GO:0030852)2.21497298
97recombinational repair (GO:0000725)2.21316999
98DNA methylation or demethylation (GO:0044728)2.20928832
99phosphatidylethanolamine metabolic process (GO:0046337)2.20068282
100regulation of hippo signaling (GO:0035330)2.19804343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.44407203
2ZNF274_21170338_ChIP-Seq_K562_Hela3.27331487
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18499985
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59281829
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41635981
6VDR_22108803_ChIP-Seq_LS180_Human2.29604004
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28913102
8GBX2_23144817_ChIP-Seq_PC3_Human2.28387427
9ER_23166858_ChIP-Seq_MCF-7_Human2.12098485
10IGF1R_20145208_ChIP-Seq_DFB_Human1.95959055
11POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87874884
12AR_21572438_ChIP-Seq_LNCaP_Human1.85089059
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82252634
14RUNX_20019798_ChIP-Seq_JUKART_Human1.78138220
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76380483
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74021293
17DROSHA_22980978_ChIP-Seq_HELA_Human1.73721107
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71358409
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69803810
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69803810
21STAT3_23295773_ChIP-Seq_U87_Human1.68719897
22SCL_19346495_ChIP-Seq_HPC-7_Human1.66678990
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65291089
24TAF15_26573619_Chip-Seq_HEK293_Human1.59414033
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59026214
26EZH2_22144423_ChIP-Seq_EOC_Human1.58854062
27TCF4_23295773_ChIP-Seq_U87_Human1.55801059
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53787167
29IRF1_19129219_ChIP-ChIP_H3396_Human1.52578631
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51567211
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49696226
32CBP_20019798_ChIP-Seq_JUKART_Human1.49696226
33GATA3_26560356_Chip-Seq_TH2_Human1.45758184
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.44920385
35BCAT_22108803_ChIP-Seq_LS180_Human1.43300651
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.42856597
37EWS_26573619_Chip-Seq_HEK293_Human1.42601554
38FUS_26573619_Chip-Seq_HEK293_Human1.38256100
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37970277
40SMAD4_21799915_ChIP-Seq_A2780_Human1.36351945
41P300_19829295_ChIP-Seq_ESCs_Human1.35030199
42CIITA_25753668_ChIP-Seq_RAJI_Human1.33600132
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.32492717
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.27557435
45GATA3_27048872_Chip-Seq_THYMUS_Human1.27452095
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27004656
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.25124465
48AHR_22903824_ChIP-Seq_MCF-7_Human1.24408399
49MYB_26560356_Chip-Seq_TH2_Human1.23691308
50AR_25329375_ChIP-Seq_VCAP_Human1.23318353
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23296706
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.22924288
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22831645
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22540283
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22306443
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21415038
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19568015
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17300587
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.15858567
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15658377
61TCF4_22108803_ChIP-Seq_LS180_Human1.14840790
62TP53_22573176_ChIP-Seq_HFKS_Human1.13570524
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.13162662
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12414870
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12154504
66RXR_22108803_ChIP-Seq_LS180_Human1.10445991
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09234453
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09156413
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08893459
70RUNX2_22187159_ChIP-Seq_PCA_Human1.08345816
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07208058
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.07169791
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06044005
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05931675
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05281294
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.05145470
77SMRT_27268052_Chip-Seq_Bcells_Human1.04442226
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.04359601
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.04087897
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03152071
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01841362
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01050493
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00307510
84OCT4_20526341_ChIP-Seq_ESCs_Human0.99684465
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99383433
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.98505375
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97952949
88VDR_24787735_ChIP-Seq_THP-1_Human0.97750426
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.97357129
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97019971
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96411242
92HOXB7_26014856_ChIP-Seq_BT474_Human0.96227676
93REST_21632747_ChIP-Seq_MESCs_Mouse0.95712065
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95063485
95MYB_26560356_Chip-Seq_TH1_Human0.94903584
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94411147
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.94400364
98ERA_21632823_ChIP-Seq_H3396_Human0.94192424
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93881323
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93798225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.07622402
2MP0008057_abnormal_DNA_replication3.04015288
3MP0002009_preneoplasia2.40334469
4MP0004043_abnormal_pH_regulation2.32405505
5MP0005551_abnormal_eye_electrophysiolog2.06469660
6MP0001986_abnormal_taste_sensitivity2.04565435
7MP0001835_abnormal_antigen_presentation1.99879800
8MP0008877_abnormal_DNA_methylation1.99876281
9MP0001800_abnormal_humoral_immune1.98908693
10MP0003195_calcinosis1.98308471
11MP0002138_abnormal_hepatobiliary_system1.92443941
12MP0001501_abnormal_sleep_pattern1.80291849
13MP0005645_abnormal_hypothalamus_physiol1.80099664
14MP0003763_abnormal_thymus_physiology1.75899341
15MP0008961_abnormal_basal_metabolism1.74569600
16MP0002928_abnormal_bile_duct1.73964643
17MP0005671_abnormal_response_to1.68631677
18MP0001968_abnormal_touch/_nociception1.65617742
19MP0003646_muscle_fatigue1.64065588
20MP0005075_abnormal_melanosome_morpholog1.63223117
21MP0002166_altered_tumor_susceptibility1.60159156
22MP0000427_abnormal_hair_cycle1.57499571
23MP0008995_early_reproductive_senescence1.56916507
24MP0002735_abnormal_chemical_nociception1.50139496
25MP0005310_abnormal_salivary_gland1.47599486
26MP0005253_abnormal_eye_physiology1.44436541
27MP0002396_abnormal_hematopoietic_system1.41565310
28MP0003045_fibrosis1.41062560
29MP0005174_abnormal_tail_pigmentation1.40795610
30MP0000015_abnormal_ear_pigmentation1.39767233
31MP0005167_abnormal_blood-brain_barrier1.34497984
32MP0003172_abnormal_lysosome_physiology1.34011022
33MP0002723_abnormal_immune_serum1.33611491
34MP0002638_abnormal_pupillary_reflex1.33038163
35MP0005646_abnormal_pituitary_gland1.31353225
36MP0002822_catalepsy1.28041713
37MP0002452_abnormal_antigen_presenting1.24039880
38MP0006072_abnormal_retinal_apoptosis1.23174928
39MP0005387_immune_system_phenotype1.21951438
40MP0001790_abnormal_immune_system1.21951438
41MP0002102_abnormal_ear_morphology1.21674857
42MP0004145_abnormal_muscle_electrophysio1.21424515
43MP0009764_decreased_sensitivity_to1.21264591
44MP0002398_abnormal_bone_marrow1.18461715
45MP0002420_abnormal_adaptive_immunity1.17847743
46MP0000383_abnormal_hair_follicle1.17285816
47MP0009278_abnormal_bone_marrow1.16683536
48MP0003787_abnormal_imprinting1.16331629
49MP0001984_abnormal_olfaction1.15589181
50MP0001819_abnormal_immune_cell1.15166824
51MP0000716_abnormal_immune_system1.12487718
52MP0004142_abnormal_muscle_tone1.10598051
53MP0005266_abnormal_metabolism1.08763072
54MP0004130_abnormal_muscle_cell1.08389634
55MP0000372_irregular_coat_pigmentation1.07096108
56MP0000689_abnormal_spleen_morphology1.06491376
57MP0009115_abnormal_fat_cell1.04367598
58MP0000703_abnormal_thymus_morphology1.04067525
59MP0005410_abnormal_fertilization1.02031959
60MP0000470_abnormal_stomach_morphology1.01202626
61MP0003724_increased_susceptibility_to1.00997593
62MP0003866_abnormal_defecation0.99675232
63MP0009046_muscle_twitch0.98337152
64MP0002006_tumorigenesis0.96751510
65MP0008872_abnormal_physiological_respon0.96567250
66MP0005386_behavior/neurological_phenoty0.96198188
67MP0004924_abnormal_behavior0.96198188
68MP0008058_abnormal_DNA_repair0.95688583
69MP0009745_abnormal_behavioral_response0.95092484
70MP0003698_abnormal_male_reproductive0.93501075
71MP0002733_abnormal_thermal_nociception0.93197020
72MP0002722_abnormal_immune_system0.92368075
73MP0002572_abnormal_emotion/affect_behav0.92113004
74MP0000230_abnormal_systemic_arterial0.90768005
75MP0001486_abnormal_startle_reflex0.90535571
76MP0000631_abnormal_neuroendocrine_gland0.90328364
77MP0003943_abnormal_hepatobiliary_system0.88765272
78MP0005397_hematopoietic_system_phenotyp0.88344130
79MP0001545_abnormal_hematopoietic_system0.88344130
80MP0004381_abnormal_hair_follicle0.88209774
81MP0005000_abnormal_immune_tolerance0.85639953
82MP0000516_abnormal_urinary_system0.85266837
83MP0005367_renal/urinary_system_phenotyp0.85266837
84MP0001873_stomach_inflammation0.84905503
85MP0003183_abnormal_peptide_metabolism0.84333429
86MP0004808_abnormal_hematopoietic_stem0.83488173
87MP0002405_respiratory_system_inflammati0.82751120
88MP0001324_abnormal_eye_pigmentation0.82221839
89MP0000685_abnormal_immune_system0.81855060
90MP0003252_abnormal_bile_duct0.81710383
91MP0002095_abnormal_skin_pigmentation0.81243700
92MP0001970_abnormal_pain_threshold0.80918768
93MP0005448_abnormal_energy_balance0.78870990
94MP0005220_abnormal_exocrine_pancreas0.78037339
95MP0001929_abnormal_gametogenesis0.77945384
96MP0002429_abnormal_blood_cell0.77017083
97MP0002168_other_aberrant_phenotype0.75939887
98MP0001270_distended_abdomen0.75264324
99MP0002067_abnormal_sensory_capabilities0.74572650
100MP0002332_abnormal_exercise_endurance0.74520927

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.84707835
2Hyperventilation (HP:0002883)4.20635308
3Congenital stationary night blindness (HP:0007642)4.09302438
4Abnormality of the renal cortex (HP:0011035)3.63559454
5Pancreatic cysts (HP:0001737)3.52418907
6Progressive cerebellar ataxia (HP:0002073)3.48512620
7Nephronophthisis (HP:0000090)3.41051134
8Abnormality of the renal medulla (HP:0100957)3.34380525
9Clumsiness (HP:0002312)3.09998445
10Severe visual impairment (HP:0001141)3.09413327
11Pancreatic fibrosis (HP:0100732)3.08999281
12Attenuation of retinal blood vessels (HP:0007843)3.04642339
13Molar tooth sign on MRI (HP:0002419)3.03473991
14Abnormality of midbrain morphology (HP:0002418)3.03473991
15Broad-based gait (HP:0002136)3.01504142
16Chronic hepatic failure (HP:0100626)2.99810788
17Gaze-evoked nystagmus (HP:0000640)2.93116651
18Tubulointerstitial nephritis (HP:0001970)2.85914871
19Absent speech (HP:0001344)2.81424235
20Protruding tongue (HP:0010808)2.80778796
21Abnormality of the fingertips (HP:0001211)2.79307645
22Stomach cancer (HP:0012126)2.78209835
23Widely spaced teeth (HP:0000687)2.75971152
24Panhypogammaglobulinemia (HP:0003139)2.74597360
25Fair hair (HP:0002286)2.69106322
26True hermaphroditism (HP:0010459)2.65868006
27Abnormal rod and cone electroretinograms (HP:0008323)2.62295841
28Thyroiditis (HP:0100646)2.57878718
29Tubular atrophy (HP:0000092)2.55250981
30Cystic liver disease (HP:0006706)2.55140211
31Renal cortical cysts (HP:0000803)2.49920908
32Tented upper lip vermilion (HP:0010804)2.39204081
33Severe combined immunodeficiency (HP:0004430)2.35540442
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35419578
35Medial flaring of the eyebrow (HP:0010747)2.34889913
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.34341885
37Clubbing of toes (HP:0100760)2.34100590
38Albinism (HP:0001022)2.31840281
39Inability to walk (HP:0002540)2.23895236
40Polydipsia (HP:0001959)2.23160737
41Abnormal drinking behavior (HP:0030082)2.23160737
42Decreased circulating renin level (HP:0003351)2.22235288
43Duplicated collecting system (HP:0000081)2.21544430
44Ectopic kidney (HP:0000086)2.21137965
45Progressive inability to walk (HP:0002505)2.18836147
46Congenital hepatic fibrosis (HP:0002612)2.16950230
47Generalized hypopigmentation of hair (HP:0011358)2.15083465
48Tubulointerstitial abnormality (HP:0001969)2.13092935
49Abnormality of macular pigmentation (HP:0008002)2.12609352
50Acute lymphatic leukemia (HP:0006721)2.12545080
51Prominent nose (HP:0000448)2.11037503
52Autoimmune thrombocytopenia (HP:0001973)2.10544326
53Abnormality of the renal collecting system (HP:0004742)2.09420556
54Hyperkalemia (HP:0002153)2.07337218
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.06197375
56Abolished electroretinogram (ERG) (HP:0000550)2.02518808
57Cerebellar dysplasia (HP:0007033)2.00859026
58Stomatitis (HP:0010280)2.00350829
59Febrile seizures (HP:0002373)1.98181575
60Poor coordination (HP:0002370)1.94306711
61Recurrent fungal infections (HP:0002841)1.93004022
62Bony spicule pigmentary retinopathy (HP:0007737)1.92997734
63Cone-rod dystrophy (HP:0000548)1.92498858
64Decreased central vision (HP:0007663)1.90096249
65Abnormal biliary tract physiology (HP:0012439)1.90037018
66Bile duct proliferation (HP:0001408)1.90037018
67Abnormality of B cell number (HP:0010975)1.89382309
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88649204
69Bulbous nose (HP:0000414)1.88581089
70Type II lissencephaly (HP:0007260)1.85343949
71Abnormality of the columella (HP:0009929)1.83937512
72Abnormality of DNA repair (HP:0003254)1.82912510
73Macular degeneration (HP:0000608)1.82213415
74Highly arched eyebrow (HP:0002553)1.81379103
75Hemiparesis (HP:0001269)1.81209151
76Lissencephaly (HP:0001339)1.80025501
77Central scotoma (HP:0000603)1.79289102
78Abnormality of T cell physiology (HP:0011840)1.79093516
79Astigmatism (HP:0000483)1.78913856
80Congenital primary aphakia (HP:0007707)1.77966995
81Truncal obesity (HP:0001956)1.77634185
82Volvulus (HP:0002580)1.76721861
83Hypoplasia of the fovea (HP:0007750)1.75384713
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.75384713
85Abnormality of T cells (HP:0002843)1.74471173
86Gait imbalance (HP:0002141)1.73776717
87Patellar aplasia (HP:0006443)1.72451618
88Polyuria (HP:0000103)1.71748156
89Colitis (HP:0002583)1.70372888
90Pachygyria (HP:0001302)1.69903814
91Nephrogenic diabetes insipidus (HP:0009806)1.67449141
92Recurrent cutaneous fungal infections (HP:0011370)1.66902452
93Chronic mucocutaneous candidiasis (HP:0002728)1.66902452
94Agammaglobulinemia (HP:0004432)1.65922165
95Chronic diarrhea (HP:0002028)1.63757771
96Partial agenesis of the corpus callosum (HP:0001338)1.62012332
97Increased corneal curvature (HP:0100692)1.62002440
98Keratoconus (HP:0000563)1.62002440
99Ulnar claw (HP:0001178)1.60608370
100Abnormality of lateral ventricle (HP:0030047)1.59161248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.45045490
2TAOK33.18701007
3BMPR1B3.13084000
4CDK122.89493080
5MAP4K22.69657799
6ACVR1B2.66179793
7INSRR2.34029185
8BLK2.24758236
9BRD42.05940700
10TXK1.98363606
11MAP4K11.68678153
12CAMK1D1.68186768
13AKT31.68104850
14KIT1.58200712
15ADRBK21.44523513
16CAMK1G1.43688850
17SIK21.41259853
18TNK21.35962700
19MAPK131.35016750
20GRK11.28476639
21TNIK1.24553619
22WNK41.23796008
23NUAK11.20596800
24SYK1.20183543
25CAMKK21.15769940
26PTK2B1.12492136
27MAPK151.11499813
28TEC1.10841776
29FGFR21.08133489
30TLK11.04364976
31PIK3CA1.03086338
32NLK1.00317528
33CHUK1.00104404
34ITK0.98767829
35IKBKE0.98002579
36TGFBR10.96349580
37MAP3K40.94747401
38GRK60.94385196
39WNK30.92971759
40DAPK20.92203855
41STK380.91018083
42IKBKB0.89755369
43OXSR10.87630594
44MAP3K70.86815086
45FLT30.85623861
46MAPK110.84447870
47NTRK30.79457573
48BTK0.78785575
49CDK30.78577964
50FES0.78274407
51LYN0.77905748
52WNK10.77597752
53CDC42BPA0.74342542
54SGK20.74238843
55RIPK40.70624384
56TRPM70.70496459
57MAPK70.68558217
58LCK0.68405055
59CAMK40.68191821
60PRKAA10.66660844
61ATR0.66492651
62EPHA30.65902186
63CSNK1A1L0.65671951
64PRKAA20.64730295
65IRAK40.64709616
66PINK10.63885439
67ERBB20.63337414
68PAK30.61118916
69ZAP700.61115681
70MAP2K60.60751372
71RPS6KA60.60608388
72HCK0.59686774
73ADRBK10.59657256
74CAMK10.57815134
75CDK80.57745454
76PIK3CG0.53830747
77CAMKK10.52845527
78IRAK10.48631891
79PRKCH0.47893398
80CASK0.47261807
81HIPK20.46659889
82NME10.45056075
83PRKCE0.43921899
84MAPK10.42983739
85MAPKAPK30.42872946
86STK390.42643088
87OBSCN0.42416451
88BRSK20.42199318
89MAPK80.42199080
90MAPK30.40811450
91MET0.40396238
92SGK10.39903163
93ABL10.38889786
94MKNK20.38754231
95BCKDK0.37685573
96MARK20.36734955
97CSF1R0.36001727
98PRKD20.35836420
99ZAK0.35078429
100RPS6KC10.34746960

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.60074666
2Asthma_Homo sapiens_hsa053102.40593131
3Graft-versus-host disease_Homo sapiens_hsa053322.38720684
4Lysine degradation_Homo sapiens_hsa003102.20237624
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13096773
6Allograft rejection_Homo sapiens_hsa053302.12264374
7Phototransduction_Homo sapiens_hsa047442.08080428
8Autoimmune thyroid disease_Homo sapiens_hsa053202.03450098
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99459880
10Primary immunodeficiency_Homo sapiens_hsa053401.98301352
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89804590
12Type I diabetes mellitus_Homo sapiens_hsa049401.87475191
13Fanconi anemia pathway_Homo sapiens_hsa034601.82660041
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76179018
15ABC transporters_Homo sapiens_hsa020101.75223191
16Linoleic acid metabolism_Homo sapiens_hsa005911.72036288
17Caffeine metabolism_Homo sapiens_hsa002321.69412292
18Taste transduction_Homo sapiens_hsa047421.55725564
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52298381
20Ether lipid metabolism_Homo sapiens_hsa005651.48672909
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47492828
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43662468
23Nitrogen metabolism_Homo sapiens_hsa009101.38035589
24Homologous recombination_Homo sapiens_hsa034401.35251097
25Dorso-ventral axis formation_Homo sapiens_hsa043201.34621984
26Staphylococcus aureus infection_Homo sapiens_hsa051501.27886917
27Morphine addiction_Homo sapiens_hsa050321.24108412
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21210292
29Olfactory transduction_Homo sapiens_hsa047401.18247912
30Nicotine addiction_Homo sapiens_hsa050331.15535571
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14574614
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07329861
33Antigen processing and presentation_Homo sapiens_hsa046121.05022408
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04919644
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.02393864
36Leishmaniasis_Homo sapiens_hsa051401.00703250
37Calcium signaling pathway_Homo sapiens_hsa040200.99908816
38Circadian entrainment_Homo sapiens_hsa047130.99313345
39Butanoate metabolism_Homo sapiens_hsa006500.99271210
40Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99132061
41Salivary secretion_Homo sapiens_hsa049700.98855754
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.96114930
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95080750
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94168517
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93482292
46Type II diabetes mellitus_Homo sapiens_hsa049300.92184498
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.90685110
48Insulin secretion_Homo sapiens_hsa049110.89588892
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86533002
50RNA polymerase_Homo sapiens_hsa030200.84816245
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.84233305
52Selenocompound metabolism_Homo sapiens_hsa004500.82980807
53Renin secretion_Homo sapiens_hsa049240.82287108
54GABAergic synapse_Homo sapiens_hsa047270.82247861
55T cell receptor signaling pathway_Homo sapiens_hsa046600.82182824
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82031066
57Hematopoietic cell lineage_Homo sapiens_hsa046400.81309823
58Platelet activation_Homo sapiens_hsa046110.81251749
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.80454275
60Glutamatergic synapse_Homo sapiens_hsa047240.80145959
61Viral myocarditis_Homo sapiens_hsa054160.79984420
62Cholinergic synapse_Homo sapiens_hsa047250.79543037
63Serotonergic synapse_Homo sapiens_hsa047260.79009339
64Circadian rhythm_Homo sapiens_hsa047100.78815001
65Inositol phosphate metabolism_Homo sapiens_hsa005620.78505449
66Regulation of autophagy_Homo sapiens_hsa041400.77990797
67Oxytocin signaling pathway_Homo sapiens_hsa049210.75348606
68RNA degradation_Homo sapiens_hsa030180.73853032
69Herpes simplex infection_Homo sapiens_hsa051680.73490738
70Choline metabolism in cancer_Homo sapiens_hsa052310.70004284
71Tuberculosis_Homo sapiens_hsa051520.69705858
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66036585
73cAMP signaling pathway_Homo sapiens_hsa040240.64955083
74Glycerolipid metabolism_Homo sapiens_hsa005610.64619836
75B cell receptor signaling pathway_Homo sapiens_hsa046620.64274551
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64101789
77Ovarian steroidogenesis_Homo sapiens_hsa049130.63709952
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63258938
79Long-term depression_Homo sapiens_hsa047300.61932097
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61817871
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60907546
82Oocyte meiosis_Homo sapiens_hsa041140.60246247
83Basal transcription factors_Homo sapiens_hsa030220.59526053
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59197400
85Influenza A_Homo sapiens_hsa051640.57346781
86Insulin resistance_Homo sapiens_hsa049310.56895367
87Toxoplasmosis_Homo sapiens_hsa051450.55189181
88Osteoclast differentiation_Homo sapiens_hsa043800.54441950
89mTOR signaling pathway_Homo sapiens_hsa041500.53199692
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50813023
91Rheumatoid arthritis_Homo sapiens_hsa053230.49744016
92Tryptophan metabolism_Homo sapiens_hsa003800.47647327
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46871051
94Notch signaling pathway_Homo sapiens_hsa043300.46667585
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.44883362
96TNF signaling pathway_Homo sapiens_hsa046680.44137747
97Non-homologous end-joining_Homo sapiens_hsa034500.43967519
98Measles_Homo sapiens_hsa051620.43630433
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42596815
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42057674

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