SPDYE17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.61629741
2cytidine deamination (GO:0009972)4.60954797
3cytidine metabolic process (GO:0046087)4.60954797
4cytidine catabolic process (GO:0006216)4.60954797
5positive regulation of calcium-mediated signaling (GO:0050850)4.44791668
6cellular ketone body metabolic process (GO:0046950)4.31884291
7T cell migration (GO:0072678)4.25148536
8protoporphyrinogen IX biosynthetic process (GO:0006782)4.19557852
9negative regulation by host of viral transcription (GO:0043922)4.14851204
10ketone body metabolic process (GO:1902224)3.94237017
11pyrimidine ribonucleoside catabolic process (GO:0046133)3.83347598
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83139311
13cilium or flagellum-dependent cell motility (GO:0001539)3.82193097
14coenzyme catabolic process (GO:0009109)3.79474720
15regulation of chronic inflammatory response (GO:0002676)3.61808318
16Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52825843
17fusion of sperm to egg plasma membrane (GO:0007342)3.51472072
18regulation of B cell differentiation (GO:0045577)3.50195970
19lymphocyte chemotaxis (GO:0048247)3.49376026
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.45110287
21positive regulation of natural killer cell mediated immunity (GO:0002717)3.44253768
22sperm motility (GO:0030317)3.43112875
23regulation of lymphocyte chemotaxis (GO:1901623)3.42731600
24cellular response to interleukin-15 (GO:0071350)3.39872242
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37957767
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.37957767
27NADH dehydrogenase complex assembly (GO:0010257)3.37957767
28negative regulation of execution phase of apoptosis (GO:1900118)3.33602486
29cofactor catabolic process (GO:0051187)3.32502251
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27091845
31protoporphyrinogen IX metabolic process (GO:0046501)3.17406838
32regulation of Golgi to plasma membrane protein transport (GO:0042996)3.17387794
33actin nucleation (GO:0045010)3.10042459
34regulation of calcium-mediated signaling (GO:0050848)3.09175175
35macrophage chemotaxis (GO:0048246)3.06615227
36lymphocyte migration (GO:0072676)3.02947249
37phosphatidylglycerol biosynthetic process (GO:0006655)3.02075671
38response to interleukin-15 (GO:0070672)3.01842930
39multicellular organism reproduction (GO:0032504)2.99736739
40histone H4-K8 acetylation (GO:0043982)2.97060802
41histone H4-K5 acetylation (GO:0043981)2.97060802
42negative regulation of leukocyte mediated immunity (GO:0002704)2.96984607
43peptidyl-histidine modification (GO:0018202)2.93859862
44inner mitochondrial membrane organization (GO:0007007)2.92560548
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91695148
46protein insertion into membrane (GO:0051205)2.89863780
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89422424
48negative regulation of cell killing (GO:0031342)2.89422424
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89255171
50regulation of natural killer cell mediated immunity (GO:0002715)2.89255171
51chaperone-mediated protein transport (GO:0072321)2.88923829
52N-acetylneuraminate metabolic process (GO:0006054)2.87408973
53negative regulation of immunoglobulin mediated immune response (GO:0002890)2.87012459
54negative regulation of B cell mediated immunity (GO:0002713)2.87012459
55dendritic cell chemotaxis (GO:0002407)2.83145032
56response to interferon-beta (GO:0035456)2.82621583
57plasma membrane fusion (GO:0045026)2.79382999
58rRNA transcription (GO:0009303)2.77852773
59positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.76317242
60positive regulation of interleukin-2 production (GO:0032743)2.74480676
61regulation of B cell receptor signaling pathway (GO:0050855)2.72787037
62mucosal-associated lymphoid tissue development (GO:0048537)2.72384866
63Peyers patch development (GO:0048541)2.72384866
64regulation of interleukin-2 biosynthetic process (GO:0045076)2.70650581
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69405875
66negative regulation of viral genome replication (GO:0045071)2.65904050
67positive regulation of lymphocyte migration (GO:2000403)2.62792153
68dendritic cell migration (GO:0036336)2.62563494
69platelet dense granule organization (GO:0060155)2.61652531
70protein targeting to Golgi (GO:0000042)2.61197591
71regulation of T cell receptor signaling pathway (GO:0050856)2.59893157
72inositol phosphate dephosphorylation (GO:0046855)2.59253378
73phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59253378
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.58646486
75regulation of gamma-delta T cell differentiation (GO:0045586)2.58511975
76ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.58171238
77nucleoside bisphosphate biosynthetic process (GO:0033866)2.58171238
78purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.58171238
79spliceosomal complex assembly (GO:0000245)2.57061679
80gamma-aminobutyric acid transport (GO:0015812)2.56898258
81inositol phosphate catabolic process (GO:0071545)2.56659869
82eosinophil chemotaxis (GO:0048245)2.55744325
83glycerophospholipid catabolic process (GO:0046475)2.55273633
84establishment of protein localization to Golgi (GO:0072600)2.55251026
85protein complex biogenesis (GO:0070271)2.53499774
86growth hormone secretion (GO:0030252)2.52903447
87negative regulation of viral transcription (GO:0032897)2.52801385
88adaptation of signaling pathway (GO:0023058)2.52597646
89negative regulation of protein localization to plasma membrane (GO:1903077)2.52546824
90negative regulation of membrane potential (GO:0045837)2.52515336
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.51522458
92regulation of leukocyte mediated cytotoxicity (GO:0001910)2.49943931
93cellular response to interferon-beta (GO:0035458)2.48970605
94protein-cofactor linkage (GO:0018065)2.48281916
95rRNA methylation (GO:0031167)2.45958218
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.45554602
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.45554602
98regulation of interleukin-2 production (GO:0032663)2.44127671
99negative regulation of T cell apoptotic process (GO:0070233)2.39746875
100retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39069481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.22712256
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.14860585
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.42730564
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42222608
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14808349
6EZH2_22144423_ChIP-Seq_EOC_Human3.05508183
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37162869
8ZNF274_21170338_ChIP-Seq_K562_Hela2.32933464
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17307293
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13043384
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08977579
12IRF8_21731497_ChIP-ChIP_J774_Mouse1.92810059
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84650238
14RUNX_20019798_ChIP-Seq_JUKART_Human1.83986639
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83014812
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78302756
17ER_23166858_ChIP-Seq_MCF-7_Human1.74996660
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73525133
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71398077
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66865947
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66696450
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63092447
23MYB_26560356_Chip-Seq_TH2_Human1.61422830
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57828140
25CIITA_25753668_ChIP-Seq_RAJI_Human1.55276028
26TAF2_19829295_ChIP-Seq_ESCs_Human1.54098482
27SCL_19346495_ChIP-Seq_HPC-7_Human1.53918689
28BCOR_27268052_Chip-Seq_Bcells_Human1.53536546
29BCL6_27268052_Chip-Seq_Bcells_Human1.49647194
30MAF_26560356_Chip-Seq_TH2_Human1.47809753
31DROSHA_22980978_ChIP-Seq_HELA_Human1.46604527
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42520891
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42353747
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38014661
35SA1_27219007_Chip-Seq_Bcells_Human1.35782267
36GATA3_26560356_Chip-Seq_TH2_Human1.34589820
37MYB_26560356_Chip-Seq_TH1_Human1.34231953
38TP53_22573176_ChIP-Seq_HFKS_Human1.33406134
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30318456
40MYC_19829295_ChIP-Seq_ESCs_Human1.29964997
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.29832361
42PHF8_20622854_ChIP-Seq_HELA_Human1.27673439
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26984951
44RAC3_21632823_ChIP-Seq_H3396_Human1.26963030
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.26787494
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24303143
47EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23239313
48UTX_26944678_Chip-Seq_JUKART_Human1.23010577
49CTCF_20526341_ChIP-Seq_ESCs_Human1.21261149
50P68_20966046_ChIP-Seq_HELA_Human1.20587049
51E2F1_20622854_ChIP-Seq_HELA_Human1.20440166
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.17871883
53GATA3_27048872_Chip-Seq_THYMUS_Human1.16571171
54CSB_26484114_Chip-Seq_FIBROBLAST_Human1.16220019
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.16081997
56NANOG_20526341_ChIP-Seq_ESCs_Human1.15572319
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.13139811
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.13119624
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13119624
60P300_27268052_Chip-Seq_Bcells_Human1.10851142
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10648636
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10617137
63AR_20517297_ChIP-Seq_VCAP_Human1.10543812
64SOX2_21211035_ChIP-Seq_LN229_Human1.10527956
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09764230
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.09708089
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05974898
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05453537
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.05221562
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04934786
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02584913
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01787508
73RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01570515
74OCT4_19829295_ChIP-Seq_ESCs_Human1.01393468
75SPI1_23127762_ChIP-Seq_K562_Human1.01187572
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99511534
77P53_21459846_ChIP-Seq_SAOS-2_Human0.99471586
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.99184022
79SMC4_20622854_ChIP-Seq_HELA_Human0.98745056
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98018252
81BCAT_22108803_ChIP-Seq_LS180_Human0.96429758
82EST1_17652178_ChIP-ChIP_JURKAT_Human0.96327333
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.95533805
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95463406
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95308260
86KLF4_19829295_ChIP-Seq_ESCs_Human0.94130722
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93884923
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92207841
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90105844
90MAF_26560356_Chip-Seq_TH1_Human0.89961017
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89632417
92SPI1_20517297_ChIP-Seq_HL60_Human0.88676250
93CBP_20019798_ChIP-Seq_JUKART_Human0.88232817
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88232817
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87314945
96VDR_23849224_ChIP-Seq_CD4+_Human0.87291168
97OCT4_20526341_ChIP-Seq_ESCs_Human0.87120456
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86805473
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86784748
100ERA_21632823_ChIP-Seq_H3396_Human0.86262079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.34275206
2MP0005671_abnormal_response_to4.27615640
3MP0010386_abnormal_urinary_bladder3.34748953
4MP0004145_abnormal_muscle_electrophysio2.57889291
5MP0001835_abnormal_antigen_presentation2.52498880
6MP0009333_abnormal_splenocyte_physiolog2.51858954
7MP0004133_heterotaxia2.42446577
8MP0004043_abnormal_pH_regulation2.28630085
9MP0009785_altered_susceptibility_to2.28612541
10MP0005083_abnormal_biliary_tract2.26042785
11MP0004147_increased_porphyrin_level2.20416773
12MP0001501_abnormal_sleep_pattern2.15716472
13MP0003303_peritoneal_inflammation2.01163348
14MP0003172_abnormal_lysosome_physiology1.98614214
15MP0004742_abnormal_vestibular_system1.90409977
16MP0002148_abnormal_hypersensitivity_rea1.90377365
17MP0001800_abnormal_humoral_immune1.86702506
18MP0001790_abnormal_immune_system1.81857150
19MP0005387_immune_system_phenotype1.81857150
20MP0005000_abnormal_immune_tolerance1.78554421
21MP0003183_abnormal_peptide_metabolism1.77620827
22MP0005645_abnormal_hypothalamus_physiol1.72351468
23MP0009745_abnormal_behavioral_response1.70859674
24MP0002095_abnormal_skin_pigmentation1.66299504
25MP0005410_abnormal_fertilization1.64060254
26MP0003436_decreased_susceptibility_to1.62298005
27MP0005379_endocrine/exocrine_gland_phen1.59539206
28MP0002723_abnormal_immune_serum1.58636155
29MP0005025_abnormal_response_to1.55894438
30MP0003045_fibrosis1.54181385
31MP0002420_abnormal_adaptive_immunity1.49254396
32MP0003866_abnormal_defecation1.46000268
33MP0001819_abnormal_immune_cell1.41543683
34MP0003786_premature_aging1.38917574
35MP0004233_abnormal_muscle_weight1.37557605
36MP0009379_abnormal_foot_pigmentation1.35251276
37MP0005551_abnormal_eye_electrophysiolog1.35079810
38MP0002452_abnormal_antigen_presenting1.34252328
39MP0001986_abnormal_taste_sensitivity1.34068278
40MP0002405_respiratory_system_inflammati1.34062580
41MP0002139_abnormal_hepatobiliary_system1.33755728
42MP0005332_abnormal_amino_acid1.33215502
43MP0002064_seizures1.32499972
44MP0005464_abnormal_platelet_physiology1.30598263
45MP0006082_CNS_inflammation1.28633995
46MP0003252_abnormal_bile_duct1.26724487
47MP0003763_abnormal_thymus_physiology1.25691829
48MP0009046_muscle_twitch1.24153765
49MP0002557_abnormal_social/conspecific_i1.23102072
50MP0000716_abnormal_immune_system1.23096859
51MP0002419_abnormal_innate_immunity1.22601212
52MP0002735_abnormal_chemical_nociception1.21445938
53MP0002398_abnormal_bone_marrow1.19378664
54MP0004142_abnormal_muscle_tone1.18862078
55MP0009697_abnormal_copulation1.18582189
56MP0002928_abnormal_bile_duct1.15975630
57MP0000371_diluted_coat_color1.15542429
58MP0000015_abnormal_ear_pigmentation1.14415550
59MP0005075_abnormal_melanosome_morpholog1.14036882
60MP0001845_abnormal_inflammatory_respons1.13478712
61MP0008469_abnormal_protein_level1.12121531
62MP0006072_abnormal_retinal_apoptosis1.11040656
63MP0001486_abnormal_startle_reflex1.09282885
64MP0005084_abnormal_gallbladder_morpholo1.05477138
65MP0003186_abnormal_redox_activity1.03073748
66MP0000689_abnormal_spleen_morphology1.01488410
67MP0002909_abnormal_adrenal_gland0.99804955
68MP0002163_abnormal_gland_morphology0.99774666
69MP0005636_abnormal_mineral_homeostasis0.99769411
70MP0009765_abnormal_xenobiotic_induced0.97233418
71MP0005310_abnormal_salivary_gland0.96476470
72MP0002429_abnormal_blood_cell0.95539952
73MP0001765_abnormal_ion_homeostasis0.91972485
74MP0001905_abnormal_dopamine_level0.91732157
75MP0003698_abnormal_male_reproductive0.91699971
76MP0002229_neurodegeneration0.90620052
77MP0000604_amyloidosis0.86660550
78MP0000703_abnormal_thymus_morphology0.86168178
79MP0009643_abnormal_urine_homeostasis0.84164658
80MP0002722_abnormal_immune_system0.83333123
81MP0003329_amyloid_beta_deposits0.82341105
82MP0005365_abnormal_bile_salt0.80729933
83MP0008873_increased_physiological_sensi0.79805313
84MP0001853_heart_inflammation0.79792647
85MP0001502_abnormal_circadian_rhythm0.79131575
86MP0009763_increased_sensitivity_to0.78449606
87MP0000639_abnormal_adrenal_gland0.76640856
88MP0000538_abnormal_urinary_bladder0.75418654
89MP0005164_abnormal_response_to0.74930292
90MP0000685_abnormal_immune_system0.74669315
91MP0002136_abnormal_kidney_physiology0.74146040
92MP0008007_abnormal_cellular_replicative0.72892241
93MP0005319_abnormal_enzyme/_coenzyme0.70366702
94MP0002272_abnormal_nervous_system0.67915217
95MP0001929_abnormal_gametogenesis0.67576226
96MP0008872_abnormal_physiological_respon0.67457518
97MP0004924_abnormal_behavior0.66437799
98MP0005386_behavior/neurological_phenoty0.66437799
99MP0008874_decreased_physiological_sensi0.66081815
100MP0002733_abnormal_thermal_nociception0.63676121

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.04846674
23-Methylglutaconic aciduria (HP:0003535)4.90135288
3Abnormality of macular pigmentation (HP:0008002)3.94221251
4Aplastic anemia (HP:0001915)3.86373544
5Pendular nystagmus (HP:0012043)3.73814869
6T lymphocytopenia (HP:0005403)3.70436113
7Abnormality of T cell number (HP:0011839)3.63239004
8Bile duct proliferation (HP:0001408)3.48253899
9Abnormal biliary tract physiology (HP:0012439)3.48253899
10Elevated erythrocyte sedimentation rate (HP:0003565)3.34749154
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.24032794
12Abolished electroretinogram (ERG) (HP:0000550)3.10635490
13Hypoproteinemia (HP:0003075)3.08601514
14Encephalitis (HP:0002383)3.03339775
15Vacuolated lymphocytes (HP:0001922)3.00590822
16Hemiplegia (HP:0002301)2.93290229
17Abnormality of the lower motor neuron (HP:0002366)2.88975853
18Autoimmune hemolytic anemia (HP:0001890)2.87784750
19Stomach cancer (HP:0012126)2.83721698
20Abnormality of T cells (HP:0002843)2.78877580
21Abnormality of DNA repair (HP:0003254)2.74831448
22Abnormality of alanine metabolism (HP:0010916)2.73884112
23Hyperalaninemia (HP:0003348)2.73884112
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73884112
25Abnormality of macrophages (HP:0004311)2.69427110
26Acute hepatic failure (HP:0006554)2.65828366
27Retinal atrophy (HP:0001105)2.51172294
28Increased serum ferritin (HP:0003281)2.48902695
29Nephronophthisis (HP:0000090)2.46384900
30Polydipsia (HP:0001959)2.36195117
31Abnormal drinking behavior (HP:0030082)2.36195117
32Spastic tetraparesis (HP:0001285)2.35674872
33Albinism (HP:0001022)2.28922869
34Delayed CNS myelination (HP:0002188)2.22135682
35Agammaglobulinemia (HP:0004432)2.22094621
36Molar tooth sign on MRI (HP:0002419)2.21087969
37Abnormality of midbrain morphology (HP:0002418)2.21087969
38Increased serum pyruvate (HP:0003542)2.20973799
39Impulsivity (HP:0100710)2.14826763
40Recurrent fungal infections (HP:0002841)2.14824216
41Attenuation of retinal blood vessels (HP:0007843)2.14754643
42Poikiloderma (HP:0001029)2.14142409
43Thyroid-stimulating hormone excess (HP:0002925)2.14075870
44Meningitis (HP:0001287)2.13983683
45Hyponatremia (HP:0002902)2.12528252
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12449406
47Hypoplasia of the brainstem (HP:0002365)2.12449406
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.10813929
49Abnormality of B cell number (HP:0010975)2.09636345
50Congenital sensorineural hearing impairment (HP:0008527)2.09186670
51Abnormality of the renal medulla (HP:0100957)2.09070117
52Entropion (HP:0000621)2.08959372
53Increased IgM level (HP:0003496)2.08202119
54Medial flaring of the eyebrow (HP:0010747)2.07121353
55Diplopia (HP:0000651)2.06045351
56Abnormality of binocular vision (HP:0011514)2.06045351
57Decreased central vision (HP:0007663)2.05725615
58Recurrent cutaneous fungal infections (HP:0011370)2.05347305
59Chronic mucocutaneous candidiasis (HP:0002728)2.05347305
60Cone-rod dystrophy (HP:0000548)2.05153278
61Pulmonary fibrosis (HP:0002206)2.04903739
62Gait imbalance (HP:0002141)2.04423814
63Recurrent viral infections (HP:0004429)2.03779027
64Recurrent sinusitis (HP:0011108)2.02932283
65Pancreatic fibrosis (HP:0100732)2.01738663
66Abnormality of transition element cation homeostasis (HP:0011030)1.98536124
67Abnormality of the renal cortex (HP:0011035)1.97919767
68Chronic hepatic failure (HP:0100626)1.93960523
69Myositis (HP:0100614)1.93684092
70Nephrogenic diabetes insipidus (HP:0009806)1.93181912
71Abnormality of T cell physiology (HP:0011840)1.92594540
72Abnormal rod and cone electroretinograms (HP:0008323)1.92494074
73Panhypogammaglobulinemia (HP:0003139)1.91554098
74Concave nail (HP:0001598)1.91428831
75Progressive visual loss (HP:0000529)1.90669743
76Hypokinesia (HP:0002375)1.87892321
77Acute necrotizing encephalopathy (HP:0006965)1.87040201
78Congenital primary aphakia (HP:0007707)1.86322823
79Polyuria (HP:0000103)1.85210311
80Abnormal mitochondria in muscle tissue (HP:0008316)1.84340653
81Abnormality of iron homeostasis (HP:0011031)1.84182606
82J-shaped sella turcica (HP:0002680)1.81150392
83Tetraplegia (HP:0002445)1.79814042
84Increased CSF lactate (HP:0002490)1.79245606
85Tongue fasciculations (HP:0001308)1.78762538
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.78717586
87Absent/shortened dynein arms (HP:0200106)1.78717586
88Chronic diarrhea (HP:0002028)1.78655961
89Epidermoid cyst (HP:0200040)1.77704484
90Abnormality of glycolysis (HP:0004366)1.77032569
91Nasal polyposis (HP:0100582)1.75531679
92Severe combined immunodeficiency (HP:0004430)1.74074166
93Abnormality of the motor neurons (HP:0002450)1.73871385
94Abnormal neuron morphology (HP:0012757)1.73871385
95Autoimmune thrombocytopenia (HP:0001973)1.71897092
96Pustule (HP:0200039)1.71886647
97Pancreatic cysts (HP:0001737)1.71175406
98Hypoplastic nipples (HP:0002557)1.70902364
99Recurrent bronchitis (HP:0002837)1.69309872
100Type II lissencephaly (HP:0007260)1.69251402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.95629015
2MAP4K24.12533887
3TXK3.48532453
4MAP4K13.34604966
5MAP3K42.96063879
6WNK42.38829936
7MAP3K122.35166030
8MUSK2.24971950
9IRAK42.10873872
10TESK12.09132140
11TESK22.00995266
12FES2.00362778
13ITK1.96063257
14RIPK41.94669735
15STK391.77299747
16PIK3CG1.76658491
17BCKDK1.59364608
18KDR1.49151785
19EIF2AK11.48066592
20MAPK151.47665589
21WNK31.43665877
22PAK61.40627256
23INSRR1.40021303
24MAP3K141.32816251
25BMPR21.29370563
26OXSR11.26183406
27PRKCQ1.19078528
28PLK41.15315880
29BRD41.10140285
30TLK11.09387199
31SYK1.08399475
32MARK11.08282421
33SCYL21.07317222
34KIT1.04445882
35PIK3CA1.01497577
36TRPM70.98881441
37ADRBK20.96288465
38TNK20.96126599
39MAPK130.93935012
40MAP2K70.90843625
41IKBKB0.90138916
42ERBB40.88675890
43MST40.87849769
44CAMKK20.86464182
45EPHA30.84617858
46MAP3K90.84236448
47MAP2K20.84148495
48MAP3K110.81825681
49ALK0.80970253
50CAMK10.80599436
51CSNK1G30.79952990
52BUB10.77694791
53ERN10.77374065
54TBK10.76805958
55EIF2AK30.75764322
56BLK0.74351765
57CAMK40.73113760
58CSNK1A1L0.71613707
59JAK20.71012701
60CSF1R0.70685266
61TAOK10.70354676
62DYRK20.70027730
63MYLK0.69368654
64BMX0.69065763
65LCK0.66980778
66PINK10.66841232
67GRK10.66812498
68GRK70.65970787
69MATK0.65898697
70ERBB30.65875209
71NME20.62703984
72EPHB10.62681770
73ADRBK10.59415645
74SIK20.57604823
75IKBKE0.57175497
76HCK0.56757652
77PDK10.56198588
78CSNK1G20.55599703
79CDK30.54960137
80MAPK120.54691903
81LYN0.52489875
82JAK30.51297917
83VRK20.50503983
84TYK20.48039787
85OBSCN0.47228007
86MARK30.46247165
87DAPK10.46106547
88BCR0.46072484
89SIK30.45862541
90ZAP700.44626212
91DAPK20.44385411
92CSK0.44243056
93BTK0.42032037
94MAP3K10.40440809
95MAP2K10.38244882
96NTRK20.38055000
97IRAK30.37270642
98PKN10.35511308
99PAK30.35086808
100MAPK110.34915270

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.96214386
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.54199167
3Oxidative phosphorylation_Homo sapiens_hsa001902.90594723
4Fatty acid biosynthesis_Homo sapiens_hsa000612.69962944
5One carbon pool by folate_Homo sapiens_hsa006702.67714189
6Graft-versus-host disease_Homo sapiens_hsa053322.65960155
7Butanoate metabolism_Homo sapiens_hsa006502.45659236
8Antigen processing and presentation_Homo sapiens_hsa046122.17007095
9Parkinsons disease_Homo sapiens_hsa050122.16440423
10Type I diabetes mellitus_Homo sapiens_hsa049402.13957353
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13150781
12Autoimmune thyroid disease_Homo sapiens_hsa053202.11984321
13Allograft rejection_Homo sapiens_hsa053301.99330065
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90002762
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.82424767
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79038015
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74280079
18T cell receptor signaling pathway_Homo sapiens_hsa046601.70201206
19Peroxisome_Homo sapiens_hsa041461.66551376
20Cardiac muscle contraction_Homo sapiens_hsa042601.63641639
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62391912
22Alzheimers disease_Homo sapiens_hsa050101.59286988
23Hematopoietic cell lineage_Homo sapiens_hsa046401.56080250
24Collecting duct acid secretion_Homo sapiens_hsa049661.52904331
25Huntingtons disease_Homo sapiens_hsa050161.52024958
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49002023
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43329823
28Salmonella infection_Homo sapiens_hsa051321.39124320
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32817195
30Sulfur relay system_Homo sapiens_hsa041221.31639248
31Proteasome_Homo sapiens_hsa030501.31108225
32Protein export_Homo sapiens_hsa030601.29783712
33Phototransduction_Homo sapiens_hsa047441.27204439
34Linoleic acid metabolism_Homo sapiens_hsa005911.26634538
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23668096
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19147634
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18860886
38Selenocompound metabolism_Homo sapiens_hsa004501.18162679
39Taste transduction_Homo sapiens_hsa047421.17845751
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17353354
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.15026543
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09879376
43RNA polymerase_Homo sapiens_hsa030201.07406615
44Rheumatoid arthritis_Homo sapiens_hsa053231.06934575
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06117999
46Ether lipid metabolism_Homo sapiens_hsa005651.04445516
47Nicotine addiction_Homo sapiens_hsa050330.93073166
48Fatty acid metabolism_Homo sapiens_hsa012120.92922967
49Olfactory transduction_Homo sapiens_hsa047400.92890305
50Measles_Homo sapiens_hsa051620.92095056
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.77625142
52RNA degradation_Homo sapiens_hsa030180.77217992
53Glutamatergic synapse_Homo sapiens_hsa047240.75570556
54Synaptic vesicle cycle_Homo sapiens_hsa047210.74759191
55Lysosome_Homo sapiens_hsa041420.74258119
56Pentose phosphate pathway_Homo sapiens_hsa000300.71067923
57Chemokine signaling pathway_Homo sapiens_hsa040620.67213517
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65487793
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.63920111
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.63432482
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59609539
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59243985
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.57925196
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53065507
65Basal transcription factors_Homo sapiens_hsa030220.52990452
66Morphine addiction_Homo sapiens_hsa050320.50939190
67Herpes simplex infection_Homo sapiens_hsa051680.50558034
68Asthma_Homo sapiens_hsa053100.50034307
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48327085
70Long-term depression_Homo sapiens_hsa047300.46624326
71B cell receptor signaling pathway_Homo sapiens_hsa046620.46562792
72Chemical carcinogenesis_Homo sapiens_hsa052040.45873574
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45305189
74Metabolic pathways_Homo sapiens_hsa011000.44849210
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43889156
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42621733
77Fatty acid degradation_Homo sapiens_hsa000710.41036770
78Ribosome_Homo sapiens_hsa030100.39708344
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39660906
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39193676
81Circadian entrainment_Homo sapiens_hsa047130.38004715
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37975563
83African trypanosomiasis_Homo sapiens_hsa051430.37553069
84Arginine biosynthesis_Homo sapiens_hsa002200.35842129
85Calcium signaling pathway_Homo sapiens_hsa040200.35668178
86Arachidonic acid metabolism_Homo sapiens_hsa005900.31816384
87Leishmaniasis_Homo sapiens_hsa051400.31524857
88Glycerolipid metabolism_Homo sapiens_hsa005610.31243137
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31149046
90Sulfur metabolism_Homo sapiens_hsa009200.31060585
91ABC transporters_Homo sapiens_hsa020100.30651878
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30439244
93Arginine and proline metabolism_Homo sapiens_hsa003300.29765359
94Viral myocarditis_Homo sapiens_hsa054160.29237997
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.26976708
96Tuberculosis_Homo sapiens_hsa051520.26960390
97Apoptosis_Homo sapiens_hsa042100.26788327
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26134971
99Serotonergic synapse_Homo sapiens_hsa047260.26065968
100Prolactin signaling pathway_Homo sapiens_hsa049170.26022673

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