ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	6.63189161
2	protein targeting to Golgi (GO:0000042)	6.16916949
3	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.90439790
4	maintenance of gastrointestinal epithelium (GO:0030277)	4.72865745
5	protein localization to Golgi apparatus (GO:0034067)	4.70466348
6	DNA double-strand break processing (GO:0000729)	4.25022422
7	L-fucose catabolic process (GO:0042355)	4.02448640
8	fucose catabolic process (GO:0019317)	4.02448640
9	L-fucose metabolic process (GO:0042354)	4.02448640
10	intra-Golgi vesicle-mediated transport (GO:0006891)	3.86023034
11	positive regulation of granulocyte differentiation (GO:0030854)	3.78582435
12	histone H3-K9 methylation (GO:0051567)	3.78087515
13	histone H3-K4 trimethylation (GO:0080182)	3.53854795
14	photoreceptor cell maintenance (GO:0045494)	3.51037312
15	epithelial structure maintenance (GO:0010669)	3.49740808
16	histone H3-K9 modification (GO:0061647)	3.47636049
17	mannosylation (GO:0097502)	3.45438107
18	rRNA catabolic process (GO:0016075)	3.41680291
19	regulation of glucokinase activity (GO:0033131)	3.28612881
20	regulation of hexokinase activity (GO:1903299)	3.28612881
21	regulation of ARF GTPase activity (GO:0032312)	3.21101318
22	axoneme assembly (GO:0035082)	3.16519163
23	multicellular organism reproduction (GO:0032504)	3.16211588
24	protein polyglutamylation (GO:0018095)	3.15743383
25	sperm motility (GO:0030317)	3.11203905
26	histone H2A acetylation (GO:0043968)	3.07227715
27	positive regulation of mRNA catabolic process (GO:0061014)	3.05963052
28	cellular ketone body metabolic process (GO:0046950)	3.04819888
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01159237
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.00116286
31	peptidyl-lysine trimethylation (GO:0018023)	2.99115338
32	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.93452367
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.93452367
34	regulation of translation, ncRNA-mediated (GO:0045974)	2.93452367
35	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.83109003
36	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.83109003
37	histone lysine methylation (GO:0034968)	2.81678972
38	tryptophan metabolic process (GO:0006568)	2.78589920
39	nephron epithelium morphogenesis (GO:0072088)	2.78124657
40	nephron tubule morphogenesis (GO:0072078)	2.78124657
41	acrosome reaction (GO:0007340)	2.77094296
42	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.76106723
43	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.76106723
44	RNA destabilization (GO:0050779)	2.73961615
45	positive regulation of organelle assembly (GO:1902117)	2.71131212
46	regulation of mRNA catabolic process (GO:0061013)	2.71073669
47	histone H3-K4 methylation (GO:0051568)	2.67800461
48	growth hormone receptor signaling pathway (GO:0060396)	2.67780301
49	regulation of cilium movement (GO:0003352)	2.66257304
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66161486
51	protein K11-linked deubiquitination (GO:0035871)	2.66148653
52	negative regulation of cAMP-mediated signaling (GO:0043951)	2.64782949
53	ketone body metabolic process (GO:1902224)	2.63802851
54	cytoplasmic mRNA processing body assembly (GO:0033962)	2.62766322
55	brain morphogenesis (GO:0048854)	2.62430044
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59916785
57	replication fork processing (GO:0031297)	2.58668275
58	methionine biosynthetic process (GO:0009086)	2.54721443
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.54339665
60	detection of light stimulus involved in visual perception (GO:0050908)	2.54339665
61	histone mRNA catabolic process (GO:0071044)	2.54135254
62	phosphatidylethanolamine metabolic process (GO:0046337)	2.54048291
63	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.51301982
64	auditory receptor cell stereocilium organization (GO:0060088)	2.49553932
65	peptidyl-lysine methylation (GO:0018022)	2.48077601
66	O-glycan processing (GO:0016266)	2.46421421
67	indolalkylamine metabolic process (GO:0006586)	2.44854114
68	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.44641179
69	N-terminal protein amino acid acetylation (GO:0006474)	2.44568093
70	protein K63-linked deubiquitination (GO:0070536)	2.44264864
71	response to pheromone (GO:0019236)	2.42871239
72	rRNA methylation (GO:0031167)	2.42659099
73	double-strand break repair via homologous recombination (GO:0000724)	2.42488194
74	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.41794761
75	intra-S DNA damage checkpoint (GO:0031573)	2.40114691
76	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.39949845
77	regulation of MHC class I biosynthetic process (GO:0045343)	2.39365401
78	positive regulation of CREB transcription factor activity (GO:0032793)	2.38099845
79	recombinational repair (GO:0000725)	2.37039130
80	Golgi to endosome transport (GO:0006895)	2.36598316
81	centriole replication (GO:0007099)	2.34539455
82	organic cation transport (GO:0015695)	2.34476632
83	microtubule nucleation (GO:0007020)	2.33866788
84	negative T cell selection (GO:0043383)	2.33226967
85	chromatin silencing (GO:0006342)	2.32757800
86	cellular response to growth hormone stimulus (GO:0071378)	2.31565118
87	male meiosis (GO:0007140)	2.31238776
88	mismatch repair (GO:0006298)	2.30001494
89	protein K48-linked deubiquitination (GO:0071108)	2.29280741
90	positive regulation of mRNA 3-end processing (GO:0031442)	2.28978209
91	DNA catabolic process, exonucleolytic (GO:0000738)	2.28658727
92	amino acid salvage (GO:0043102)	2.28243933
93	L-methionine salvage (GO:0071267)	2.28243933
94	L-methionine biosynthetic process (GO:0071265)	2.28243933
95	ubiquinone biosynthetic process (GO:0006744)	2.27745085
96	protein O-linked glycosylation (GO:0006493)	2.27646292
97	positive regulation of mRNA metabolic process (GO:1903313)	2.27550698
98	spermatid development (GO:0007286)	2.26309325
99	DNA alkylation (GO:0006305)	2.23370870
100	DNA methylation (GO:0006306)	2.23370870

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.31651151
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13066213
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.98856798
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70282025
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.54883320
6	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.54224816
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42087024
8	* ER_23166858_ChIP-Seq_MCF-7_Human	2.36529137
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.19827662
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12026075
11	VDR_22108803_ChIP-Seq_LS180_Human	2.06324755
12	DROSHA_22980978_ChIP-Seq_HELA_Human	1.98006718
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92266930
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.90018093
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.86755075
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83380259
17	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.82520007
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.76240390
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75967217
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.75581359
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.73093452
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.73093452
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.71031246
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68641263
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68398251
26	STAT3_23295773_ChIP-Seq_U87_Human	1.62591770
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.60430718
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60284794
29	RUNX_20019798_ChIP-Seq_JUKART_Human	1.60164989
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59434604
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55034473
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53888124
33	GATA3_26560356_Chip-Seq_TH2_Human	1.53765367
34	TCF4_23295773_ChIP-Seq_U87_Human	1.51351609
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.49040322
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.47813374
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47351845
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.38607713
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38166944
40	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.38113645
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36384747
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35842136
43	FUS_26573619_Chip-Seq_HEK293_Human	1.35692777
44	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.33696432
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32706913
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32706913
47	GATA3_27048872_Chip-Seq_THYMUS_Human	1.32117947
48	EWS_26573619_Chip-Seq_HEK293_Human	1.30928887
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30260090
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29098909
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.28916033
52	MYB_26560356_Chip-Seq_TH2_Human	1.28730886
53	AR_25329375_ChIP-Seq_VCAP_Human	1.27325088
54	P300_19829295_ChIP-Seq_ESCs_Human	1.24502059
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17448720
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14821375
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14537619
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14273828
59	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14122236
60	OCT4_20526341_ChIP-Seq_ESCs_Human	1.13642508
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12934168
62	SMRT_27268052_Chip-Seq_Bcells_Human	1.12678253
63	ERA_21632823_ChIP-Seq_H3396_Human	1.12207590
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.11800599
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10870816
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.10617870
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10280068
68	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10266220
69	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10070128
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09925224
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09786256
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09162512
73	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09157069
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.08664608
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08183794
76	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07986208
77	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.07794125
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07575582
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06820759
80	GATA1_22025678_ChIP-Seq_K562_Human	1.01955401
81	GATA3_26560356_Chip-Seq_TH1_Human	1.01900215
82	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.01771974
83	EZH2_22144423_ChIP-Seq_EOC_Human	1.01712980
84	VDR_23849224_ChIP-Seq_CD4+_Human	1.01315934
85	AR_20517297_ChIP-Seq_VCAP_Human	1.01144009
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00489463
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00177921
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.00005942
89	TBL1_22424771_ChIP-Seq_293T_Human	0.99869783
90	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.99379114
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99051379
92	MYB_26560356_Chip-Seq_TH1_Human	0.98931064
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98705127
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97398677
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97333807
96	NCOR_22424771_ChIP-Seq_293T_Human	0.97114392
97	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95334928
98	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95214004
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.95194435
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93875668

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	2.66196610
2	MP0008057_abnormal_DNA_replication	2.65341218
3	MP0002138_abnormal_hepatobiliary_system	2.45284198
4	MP0005551_abnormal_eye_electrophysiolog	2.24126028
5	MP0003195_calcinosis	2.21598118
6	MP0000465_gastrointestinal_hemorrhage	2.16833447
7	MP0008995_early_reproductive_senescence	2.14965963
8	MP0001968_abnormal_touch/_nociception	2.05502614
9	MP0001984_abnormal_olfaction	2.02105750
10	MP0005645_abnormal_hypothalamus_physiol	1.99034206
11	MP0003763_abnormal_thymus_physiology	1.93811161
12	MP0008058_abnormal_DNA_repair	1.92295748
13	MP0008877_abnormal_DNA_methylation	1.92286956
14	MP0005410_abnormal_fertilization	1.89267622
15	MP0005253_abnormal_eye_physiology	1.89101057
16	MP0000569_abnormal_digit_pigmentation	1.82467589
17	MP0003866_abnormal_defecation	1.81937282
18	MP0001501_abnormal_sleep_pattern	1.74078412
19	MP0001986_abnormal_taste_sensitivity	1.73105073
20	MP0003786_premature_aging	1.68502403
21	MP0000427_abnormal_hair_cycle	1.63971377
22	MP0005646_abnormal_pituitary_gland	1.63877444
23	MP0010094_abnormal_chromosome_stability	1.61348032
24	MP0003045_fibrosis	1.57257455
25	MP0006072_abnormal_retinal_apoptosis	1.57240453
26	MP0002102_abnormal_ear_morphology	1.56218555
27	MP0001485_abnormal_pinna_reflex	1.54369644
28	MP0005310_abnormal_salivary_gland	1.52996794
29	MP0000383_abnormal_hair_follicle	1.51664751
30	MP0002822_catalepsy	1.45843609
31	MP0008004_abnormal_stomach_pH	1.43637233
32	MP0008961_abnormal_basal_metabolism	1.43297158
33	MP0003787_abnormal_imprinting	1.43063034
34	MP0003698_abnormal_male_reproductive	1.32337190
35	MP0001929_abnormal_gametogenesis	1.30666160
36	MP0002638_abnormal_pupillary_reflex	1.29569723
37	MP0005671_abnormal_response_to	1.26625967
38	MP0001835_abnormal_antigen_presentation	1.25823193
39	MP0002736_abnormal_nociception_after	1.24024392
40	MP0005167_abnormal_blood-brain_barrier	1.23900291
41	MP0002166_altered_tumor_susceptibility	1.22742489
42	MP0005083_abnormal_biliary_tract	1.21330835
43	MP0001800_abnormal_humoral_immune	1.20176163
44	MP0009278_abnormal_bone_marrow	1.19934303
45	MP0001270_distended_abdomen	1.19557173
46	MP0003646_muscle_fatigue	1.17995783
47	MP0003878_abnormal_ear_physiology	1.16359193
48	MP0005377_hearing/vestibular/ear_phenot	1.16359193
49	MP0000538_abnormal_urinary_bladder	1.11855123
50	MP0008872_abnormal_physiological_respon	1.10220245
51	MP0005220_abnormal_exocrine_pancreas	1.09877439
52	MP0009115_abnormal_fat_cell	1.08873679
53	MP0004264_abnormal_extraembryonic_tissu	1.08583073
54	MP0004145_abnormal_muscle_electrophysio	1.08149700
55	MP0010307_abnormal_tumor_latency	1.03230607
56	MP0000013_abnormal_adipose_tissue	0.99610022
57	MP0000470_abnormal_stomach_morphology	0.99438201
58	MP0002735_abnormal_chemical_nociception	0.98855073
59	MP0003943_abnormal_hepatobiliary_system	0.95758919
60	MP0000703_abnormal_thymus_morphology	0.95163548
61	MP0005266_abnormal_metabolism	0.94608041
62	MP0002168_other_aberrant_phenotype	0.93407954
63	MP0001765_abnormal_ion_homeostasis	0.92678133
64	MP0010155_abnormal_intestine_physiology	0.92669687
65	MP0002970_abnormal_white_adipose	0.91283403
66	MP0003172_abnormal_lysosome_physiology	0.90868305
67	MP0005397_hematopoietic_system_phenotyp	0.89799793
68	MP0001545_abnormal_hematopoietic_system	0.89799793
69	MP0002751_abnormal_autonomic_nervous	0.88589083
70	MP0002398_abnormal_bone_marrow	0.86412154
71	MP0004924_abnormal_behavior	0.86226127
72	MP0005386_behavior/neurological_phenoty	0.86226127
73	MP0002067_abnormal_sensory_capabilities	0.86084772
74	MP0002210_abnormal_sex_determination	0.85836009
75	MP0002229_neurodegeneration	0.85454675
76	MP0002928_abnormal_bile_duct	0.85149631
77	MP0004147_increased_porphyrin_level	0.83021831
78	MP0002876_abnormal_thyroid_physiology	0.82928269
79	MP0003718_maternal_effect	0.82203521
80	MP0001502_abnormal_circadian_rhythm	0.81998840
81	MP0001486_abnormal_startle_reflex	0.81831083
82	MP0002127_abnormal_cardiovascular_syste	0.80634578
83	MP0001666_abnormal_nutrient_absorption	0.80461504
84	MP0001664_abnormal_digestion	0.80446417
85	MP0000372_irregular_coat_pigmentation	0.79070046
86	MP0005448_abnormal_energy_balance	0.78996157
87	MP0002420_abnormal_adaptive_immunity	0.78018655
88	MP0005395_other_phenotype	0.77800529
89	MP0009046_muscle_twitch	0.76605799
90	MP0001819_abnormal_immune_cell	0.75497028
91	MP0002722_abnormal_immune_system	0.75060349
92	MP0002723_abnormal_immune_serum	0.73784545
93	MP0000230_abnormal_systemic_arterial	0.73642488
94	MP0002452_abnormal_antigen_presenting	0.72888318
95	MP0001764_abnormal_homeostasis	0.71315333
96	MP0010386_abnormal_urinary_bladder	0.71089798
97	MP0000716_abnormal_immune_system	0.70665098
98	MP0005076_abnormal_cell_differentiation	0.69862316
99	MP0005075_abnormal_melanosome_morpholog	0.67920916
100	MP0000689_abnormal_spleen_morphology	0.66522181

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.60219462
2	Abnormality of the fingertips (HP:0001211)	4.00080382
3	Hyperkalemia (HP:0002153)	3.79783692
4	Genetic anticipation (HP:0003743)	3.48397223
5	Hyperventilation (HP:0002883)	3.36994130
6	Abnormality of the renal cortex (HP:0011035)	3.22943023
7	Progressive cerebellar ataxia (HP:0002073)	3.05189335
8	Severe combined immunodeficiency (HP:0004430)	2.97763559
9	Fair hair (HP:0002286)	2.90989515
10	Panhypogammaglobulinemia (HP:0003139)	2.90700015
11	Ectopic kidney (HP:0000086)	2.88275256
12	Neonatal respiratory distress (HP:0002643)	2.87871968
13	Thyroiditis (HP:0100646)	2.79685416
14	Gaze-evoked nystagmus (HP:0000640)	2.77253114
15	Abnormality of the renal medulla (HP:0100957)	2.74215730
16	Clubbing of toes (HP:0100760)	2.70294629
17	Renal cortical cysts (HP:0000803)	2.66258225
18	Pancreatic cysts (HP:0001737)	2.65546152
19	Broad-based gait (HP:0002136)	2.63977672
20	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.62414341
21	Absent speech (HP:0001344)	2.59458695
22	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.58838516
23	Duplicated collecting system (HP:0000081)	2.53976885
24	Attenuation of retinal blood vessels (HP:0007843)	2.51635480
25	Abnormal hair whorl (HP:0010721)	2.47314627
26	Cerebellar dysplasia (HP:0007033)	2.46045750
27	Clumsiness (HP:0002312)	2.45715982
28	Prominent nose (HP:0000448)	2.43776232
29	Abnormal biliary tract physiology (HP:0012439)	2.43664025
30	Bile duct proliferation (HP:0001408)	2.43664025
31	Chronic hepatic failure (HP:0100626)	2.41009526
32	Congenital stationary night blindness (HP:0007642)	2.39898752
33	Abnormality of the parathyroid morphology (HP:0011766)	2.39478411
34	Impulsivity (HP:0100710)	2.38179198
35	Nephronophthisis (HP:0000090)	2.33093541
36	Chromsome breakage (HP:0040012)	2.32463721
37	Cystic liver disease (HP:0006706)	2.31692337
38	Widely spaced teeth (HP:0000687)	2.29140176
39	Progressive inability to walk (HP:0002505)	2.28487882
40	Abnormality of the nasal septum (HP:0000419)	2.28273859
41	Abnormality of chloride homeostasis (HP:0011422)	2.25751979
42	Abnormality of the preputium (HP:0100587)	2.25358946
43	Generalized hypopigmentation of hair (HP:0011358)	2.24907444
44	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.24651703
45	Pustule (HP:0200039)	2.24440345
46	Abnormality of the ileum (HP:0001549)	2.22076631
47	Type II lissencephaly (HP:0007260)	2.21402236
48	Abnormality of the astrocytes (HP:0100707)	2.20526656
49	Astrocytoma (HP:0009592)	2.20526656
50	Pancreatic fibrosis (HP:0100732)	2.19338210
51	Spinal muscular atrophy (HP:0007269)	2.16451395
52	Abnormality of the columella (HP:0009929)	2.16415869
53	Hypoplasia of the thymus (HP:0000778)	2.13334659
54	Abnormality of the renal collecting system (HP:0004742)	2.13104154
55	Ependymoma (HP:0002888)	2.11362479
56	Tubulointerstitial abnormality (HP:0001969)	2.10629183
57	Abnormality of eosinophils (HP:0001879)	2.10365762
58	Molar tooth sign on MRI (HP:0002419)	2.09154532
59	Abnormality of midbrain morphology (HP:0002418)	2.09154532
60	Tubular atrophy (HP:0000092)	2.07382666
61	Meckel diverticulum (HP:0002245)	2.05684917
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05464319
63	Abnormal protein N-linked glycosylation (HP:0012347)	2.05464319
64	Abnormal protein glycosylation (HP:0012346)	2.05464319
65	Abnormal glycosylation (HP:0012345)	2.05464319
66	Hypoproteinemia (HP:0003075)	2.04689191
67	Abnormality of DNA repair (HP:0003254)	2.04300846
68	Eosinophilia (HP:0001880)	2.02556971
69	True hermaphroditism (HP:0010459)	2.02010289
70	Combined immunodeficiency (HP:0005387)	2.01192529
71	Inability to walk (HP:0002540)	2.00950448
72	Abnormality of chromosome stability (HP:0003220)	2.00124583
73	Medial flaring of the eyebrow (HP:0010747)	2.00013822
74	Progressive microcephaly (HP:0000253)	1.99061129
75	Glioma (HP:0009733)	1.96975207
76	Enlarged epiphyses (HP:0010580)	1.94532403
77	Granulocytopenia (HP:0001913)	1.93949332
78	Stomach cancer (HP:0012126)	1.92676254
79	Sloping forehead (HP:0000340)	1.90614591
80	Chronic diarrhea (HP:0002028)	1.90286154
81	Chronic mucocutaneous candidiasis (HP:0002728)	1.89590125
82	Recurrent cutaneous fungal infections (HP:0011370)	1.89590125
83	Truncal obesity (HP:0001956)	1.88832139
84	Abnormality of lateral ventricle (HP:0030047)	1.88788203
85	Inflammation of the large intestine (HP:0002037)	1.88078452
86	Abnormality of the carotid arteries (HP:0005344)	1.87662532
87	Facial diplegia (HP:0001349)	1.87526820
88	Abnormality of T cell physiology (HP:0011840)	1.85140567
89	Increased CSF protein (HP:0002922)	1.82069704
90	Tented upper lip vermilion (HP:0010804)	1.81708267
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.81519574
92	Cone-rod dystrophy (HP:0000548)	1.81400052
93	Long clavicles (HP:0000890)	1.80990439
94	Villous atrophy (HP:0011473)	1.80180209
95	Abnormality of small intestinal villus morphology (HP:0011472)	1.80180209
96	Protruding tongue (HP:0010808)	1.79636436
97	Poor coordination (HP:0002370)	1.79441964
98	Abnormality of potassium homeostasis (HP:0011042)	1.79050022
99	Bulbous nose (HP:0000414)	1.77674758
100	Albinism (HP:0001022)	1.76678435

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.38052245
2	BMPR1B	3.91180608
3	WNK4	3.89765736
4	CDK12	2.77486552
5	MAP4K2	2.49674170
6	MST1R	2.20764914
7	NME1	2.19079949
8	TAOK3	2.17262765
9	BRD4	2.13468045
10	TXK	2.11048560
11	INSRR	1.85010904
12	CAMK1D	1.84574361
13	WNK1	1.70453239
14	PINK1	1.69313267
15	MET	1.69040372
16	STK39	1.61991627
17	BLK	1.55402901
18	EPHA3	1.47904268
19	CDK8	1.41641461
20	CAMK1G	1.41443055
21	STK38	1.41022895
22	AKT3	1.39847106
23	NUAK1	1.31659167
24	ACVR1B	1.28247928
25	MAP2K6	1.22438755
26	TNIK	1.22358163
27	GRK1	1.21298669
28	OXSR1	1.20705946
29	PIK3CA	1.18479375
30	MAPK13	1.13757214
31	CSNK1A1L	1.11426959
32	TNK2	1.07323207
33	WNK3	1.06085385
34	MAP4K1	1.05501464
35	NLK	1.03139404
36	TGFBR1	1.02283022
37	CAMKK2	1.01902409
38	ADRBK2	0.98379409
39	ZAK	0.97158420
40	MARK3	0.90205053
41	SIK3	0.89247433
42	STK38L	0.88755120
43	MAPK11	0.88426480
44	PTK2B	0.86203399
45	TRIM28	0.85111739
46	MAP3K4	0.84814523
47	CASK	0.84774562
48	BCR	0.84021856
49	KIT	0.83506027
50	CHUK	0.82694319
51	PLK4	0.80351990
52	MKNK2	0.79168056
53	TEC	0.78842513
54	ATR	0.78531197
55	MUSK	0.78413261
56	BCKDK	0.78340114
57	PLK2	0.72388926
58	ERBB2	0.72190433
59	CDK3	0.72126932
60	MAPK15	0.70524135
61	MKNK1	0.70239664
62	CSNK1G3	0.69277550
63	PAK3	0.69115906
64	SYK	0.68074806
65	CSNK1G1	0.67151116
66	FES	0.64969515
67	MAP3K7	0.64508216
68	CAMK4	0.64321980
69	PRKAA2	0.63305963
70	CDK9	0.63209560
71	PRKAA1	0.62350552
72	ITK	0.60204092
73	LCK	0.59706206
74	PDK2	0.59173749
75	FGFR2	0.57504422
76	SIK2	0.55129383
77	NEK2	0.54725786
78	VRK1	0.49702380
79	ATM	0.48448432
80	RPS6KA5	0.47637473
81	IKBKB	0.46197061
82	TRPM7	0.45936149
83	PRKCE	0.45568705
84	CLK1	0.44378752
85	MAPK1	0.43506774
86	GRK6	0.43170651
87	ZAP70	0.41430180
88	TLK1	0.40948115
89	CAMK1	0.40854126
90	SGK1	0.40790238
91	SRPK1	0.40432355
92	DAPK2	0.37599075
93	PRKCQ	0.37211755
94	CSNK1A1	0.37007241
95	IKBKE	0.36693516
96	BTK	0.36237922
97	HCK	0.36034344
98	LYN	0.35691987
99	CHEK1	0.35525631
100	MTOR	0.33516023

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.08927204
2	Lysine degradation_Homo sapiens_hsa00310	2.96198383
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.68022521
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.40730591
5	* Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.34811835
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29352420
7	Butanoate metabolism_Homo sapiens_hsa00650	2.27177999
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15392855
9	ABC transporters_Homo sapiens_hsa02010	2.03802508
10	Phototransduction_Homo sapiens_hsa04744	2.01389450
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99149241
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.96116152
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.83590041
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.72854982
15	RNA polymerase_Homo sapiens_hsa03020	1.72846834
16	Homologous recombination_Homo sapiens_hsa03440	1.71260904
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66765756
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.64559649
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62362945
20	* Oocyte meiosis_Homo sapiens_hsa04114	1.62099572
21	Olfactory transduction_Homo sapiens_hsa04740	1.61917800
22	Basal transcription factors_Homo sapiens_hsa03022	1.55725538
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.54988624
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.52702169
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.50316654
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41170687
27	Taste transduction_Homo sapiens_hsa04742	1.37134161
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33214870
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31937378
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29814890
31	Asthma_Homo sapiens_hsa05310	1.27889664
32	Allograft rejection_Homo sapiens_hsa05330	1.27652119
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26927349
34	Salivary secretion_Homo sapiens_hsa04970	1.22064838
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.21897669
36	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.16727130
37	RNA degradation_Homo sapiens_hsa03018	1.12182971
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09753272
39	One carbon pool by folate_Homo sapiens_hsa00670	1.08999974
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.04803257
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03819564
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.01557084
43	Regulation of autophagy_Homo sapiens_hsa04140	1.01354269
44	Base excision repair_Homo sapiens_hsa03410	1.00663220
45	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00395434
46	Propanoate metabolism_Homo sapiens_hsa00640	0.98927294
47	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.90914586
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.90270603
49	Insulin secretion_Homo sapiens_hsa04911	0.89437323
50	Peroxisome_Homo sapiens_hsa04146	0.88095099
51	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.85863813
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82272394
53	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80413062
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.78182007
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76861018
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76460161
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.75790063
58	RNA transport_Homo sapiens_hsa03013	0.75463776
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75411622
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.74094981
61	Circadian rhythm_Homo sapiens_hsa04710	0.73991685
62	Herpes simplex infection_Homo sapiens_hsa05168	0.72780760
63	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71819027
64	Other glycan degradation_Homo sapiens_hsa00511	0.71767855
65	Circadian entrainment_Homo sapiens_hsa04713	0.67286314
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.66276904
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.61801186
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.59954556
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57321333
70	Purine metabolism_Homo sapiens_hsa00230	0.55344019
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.55035841
72	Amphetamine addiction_Homo sapiens_hsa05031	0.53577730
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.53220868
74	Glucagon signaling pathway_Homo sapiens_hsa04922	0.49208067
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.48971154
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48738943
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47595455
78	Platelet activation_Homo sapiens_hsa04611	0.47140679
79	Pancreatic secretion_Homo sapiens_hsa04972	0.45635003
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44099973
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43375257
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42294975
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42060859
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.41817588
85	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.41672917
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37826957
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37403338
88	Measles_Homo sapiens_hsa05162	0.35889947
89	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35157524
90	Viral myocarditis_Homo sapiens_hsa05416	0.34970754
91	Notch signaling pathway_Homo sapiens_hsa04330	0.33803712
92	African trypanosomiasis_Homo sapiens_hsa05143	0.33702786
93	Insulin resistance_Homo sapiens_hsa04931	0.33133753
94	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33103522
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32634081
96	Nicotine addiction_Homo sapiens_hsa05033	0.32571603
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32322548
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32122400
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29943339
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29773389

SPDYE2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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