ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mannosylation (GO:0097502)	4.06315483
2	DNA deamination (GO:0045006)	3.89433126
3	ubiquinone biosynthetic process (GO:0006744)	3.89114679
4	protein complex biogenesis (GO:0070271)	3.87257584
5	cytochrome complex assembly (GO:0017004)	3.75320986
6	preassembly of GPI anchor in ER membrane (GO:0016254)	3.66339161
7	platelet dense granule organization (GO:0060155)	3.62860444
8	fucose catabolic process (GO:0019317)	3.61164996
9	L-fucose metabolic process (GO:0042354)	3.61164996
10	L-fucose catabolic process (GO:0042355)	3.61164996
11	tryptophan metabolic process (GO:0006568)	3.58518314
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55906406
13	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.53293837
14	ubiquinone metabolic process (GO:0006743)	3.50578771
15	piRNA metabolic process (GO:0034587)	3.48054090
16	respiratory chain complex IV assembly (GO:0008535)	3.34994693
17	GPI anchor metabolic process (GO:0006505)	3.34102008
18	metallo-sulfur cluster assembly (GO:0031163)	3.32706366
19	iron-sulfur cluster assembly (GO:0016226)	3.32706366
20	cellular ketone body metabolic process (GO:0046950)	3.32216510
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.28160652
22	protein polyglutamylation (GO:0018095)	3.27614028
23	regulation of cilium movement (GO:0003352)	3.24727324
24	tryptophan catabolic process (GO:0006569)	3.22041571
25	indole-containing compound catabolic process (GO:0042436)	3.22041571
26	indolalkylamine catabolic process (GO:0046218)	3.22041571
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21564626
28	NADH dehydrogenase complex assembly (GO:0010257)	3.21564626
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21564626
30	response to pheromone (GO:0019236)	3.21466793
31	deoxyribonucleotide catabolic process (GO:0009264)	3.21322127
32	negative regulation of B cell apoptotic process (GO:0002903)	3.20914528
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19716713
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19716713
35	quinone biosynthetic process (GO:1901663)	3.18321053
36	positive regulation of prostaglandin secretion (GO:0032308)	3.17614941
37	indolalkylamine metabolic process (GO:0006586)	3.16283614
38	DNA double-strand break processing (GO:0000729)	3.15295305
39	negative regulation of mast cell activation (GO:0033004)	3.12646536
40	deoxyribose phosphate catabolic process (GO:0046386)	3.10975018
41	GPI anchor biosynthetic process (GO:0006506)	3.10362633
42	axoneme assembly (GO:0035082)	3.10244081
43	purine deoxyribonucleotide catabolic process (GO:0009155)	3.09474422
44	pyrimidine nucleotide catabolic process (GO:0006244)	3.08791489
45	replication fork processing (GO:0031297)	3.08430650
46	kynurenine metabolic process (GO:0070189)	3.04981138
47	seminiferous tubule development (GO:0072520)	3.03966618
48	protein-cofactor linkage (GO:0018065)	3.03034363
49	ketone body metabolic process (GO:1902224)	3.02062705
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01234686
51	amino acid salvage (GO:0043102)	2.98463338
52	L-methionine salvage (GO:0071267)	2.98463338
53	L-methionine biosynthetic process (GO:0071265)	2.98463338
54	regulation of B cell apoptotic process (GO:0002902)	2.96277483
55	negative regulation of telomere maintenance (GO:0032205)	2.96104019
56	base-excision repair, AP site formation (GO:0006285)	2.91411368
57	branched-chain amino acid catabolic process (GO:0009083)	2.86449680
58	maturation of 5.8S rRNA (GO:0000460)	2.86156781
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83490267
60	DNA catabolic process, exonucleolytic (GO:0000738)	2.81105573
61	DNA integration (GO:0015074)	2.77167833
62	protein localization to cilium (GO:0061512)	2.74451223
63	rRNA catabolic process (GO:0016075)	2.73840574
64	immunoglobulin mediated immune response (GO:0016064)	2.71403830
65	C-terminal protein lipidation (GO:0006501)	2.68786744
66	anterograde synaptic vesicle transport (GO:0048490)	2.65998131
67	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.64311001
68	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.63192407
69	cell wall macromolecule metabolic process (GO:0044036)	2.61394120
70	multicellular organism reproduction (GO:0032504)	2.60167272
71	detection of light stimulus involved in visual perception (GO:0050908)	2.59075300
72	detection of light stimulus involved in sensory perception (GO:0050962)	2.59075300
73	positive regulation of fatty acid transport (GO:2000193)	2.56710659
74	mismatch repair (GO:0006298)	2.56415410
75	inositol phosphate catabolic process (GO:0071545)	2.55556915
76	glycolipid biosynthetic process (GO:0009247)	2.53741641
77	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.53621837
78	adenosine metabolic process (GO:0046085)	2.53149456
79	NAD biosynthetic process (GO:0009435)	2.51424310
80	auditory receptor cell stereocilium organization (GO:0060088)	2.51129335
81	lipopolysaccharide biosynthetic process (GO:0009103)	2.49661197
82	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.49536560
83	photoreceptor cell maintenance (GO:0045494)	2.47758584
84	protein deneddylation (GO:0000338)	2.46684461
85	C-terminal protein amino acid modification (GO:0018410)	2.45124633
86	response to interferon-beta (GO:0035456)	2.43839909
87	purine deoxyribonucleotide metabolic process (GO:0009151)	2.42879918
88	cellular biogenic amine catabolic process (GO:0042402)	2.42878797
89	amine catabolic process (GO:0009310)	2.42878797
90	positive regulation of icosanoid secretion (GO:0032305)	2.41999110
91	DNA demethylation (GO:0080111)	2.41878726
92	branched-chain amino acid metabolic process (GO:0009081)	2.41333984
93	S-adenosylmethionine metabolic process (GO:0046500)	2.40850441
94	positive regulation of mitochondrial fission (GO:0090141)	2.39820804
95	aggressive behavior (GO:0002118)	2.38762796
96	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.36160625
97	2-deoxyribonucleotide metabolic process (GO:0009394)	2.36109651
98	adaptation of signaling pathway (GO:0023058)	2.35552686
99	quinone metabolic process (GO:1901661)	2.34173480
100	tRNA modification (GO:0006400)	2.34111239

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.77920372
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.35307208
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.25043609
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.77520922
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.68875667
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.66723869
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.65298156
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63226776
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.54295121
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50248192
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40639192
12	VDR_22108803_ChIP-Seq_LS180_Human	2.27051274
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25681941
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18926213
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17013961
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.07822269
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.06724621
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00661593
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.85317689
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.83728877
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.81026115
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78298389
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73528361
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.73248731
25	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69724893
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68637495
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68462922
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.67341464
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66162750
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66066736
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.58960203
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54909217
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54501282
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.54501282
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50900769
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.49447122
37	EWS_26573619_Chip-Seq_HEK293_Human	1.49312409
38	GATA3_26560356_Chip-Seq_TH2_Human	1.43399683
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41682715
40	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.41274204
41	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.40665545
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40282619
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40282619
44	AR_20517297_ChIP-Seq_VCAP_Human	1.39241581
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37461514
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37203233
47	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.35436164
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35128863
49	P300_19829295_ChIP-Seq_ESCs_Human	1.33838762
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32140431
51	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31533292
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28519707
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26856096
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25168884
55	FUS_26573619_Chip-Seq_HEK293_Human	1.24802112
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24017254
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23875386
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22362515
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21850827
60	NCOR_22424771_ChIP-Seq_293T_Human	1.20466496
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19872874
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19872874
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18964047
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18691119
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17758203
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17447978
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16658320
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14348586
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13514405
70	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.11826569
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11139936
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10553722
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09630822
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09227059
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09085580
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07155392
77	SCL_19346495_ChIP-Seq_HPC-7_Human	1.07088681
78	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06800822
79	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.06616048
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.06371243
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05258061
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05161729
83	ERA_21632823_ChIP-Seq_H3396_Human	1.04149256
84	TAF15_26573619_Chip-Seq_HEK293_Human	1.03046646
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02861533
86	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.01851067
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01554987
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00678583
89	BCAT_22108803_ChIP-Seq_LS180_Human	1.00608081
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.99993739
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99674847
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.99546619
93	RAC3_21632823_ChIP-Seq_H3396_Human	0.98715460
94	GABP_19822575_ChIP-Seq_HepG2_Human	0.98320543
95	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97864829
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97719265
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97175152
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96822756
99	AR_25329375_ChIP-Seq_VCAP_Human	0.96479711
100	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95664083

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	2.86235600
2	MP0008875_abnormal_xenobiotic_pharmacok	2.68544736
3	MP0002102_abnormal_ear_morphology	2.63185593
4	MP0006072_abnormal_retinal_apoptosis	2.55694022
5	MP0002736_abnormal_nociception_after	2.51301057
6	MP0005645_abnormal_hypothalamus_physiol	2.48865831
7	MP0008877_abnormal_DNA_methylation	2.44687841
8	MP0005646_abnormal_pituitary_gland	2.37407452
9	MP0000372_irregular_coat_pigmentation	2.35359456
10	MP0008058_abnormal_DNA_repair	2.24453849
11	MP0005551_abnormal_eye_electrophysiolog	2.20376723
12	MP0001501_abnormal_sleep_pattern	2.08982834
13	MP0001984_abnormal_olfaction	2.01618986
14	MP0005253_abnormal_eye_physiology	1.99616882
15	MP0005075_abnormal_melanosome_morpholog	1.97538847
16	MP0001986_abnormal_taste_sensitivity	1.96118905
17	MP0004147_increased_porphyrin_level	1.94090100
18	MP0003195_calcinosis	1.93257535
19	MP0001835_abnormal_antigen_presentation	1.80204463
20	MP0005410_abnormal_fertilization	1.77698443
21	MP0000569_abnormal_digit_pigmentation	1.68934498
22	MP0003880_abnormal_central_pattern	1.68256602
23	MP0005671_abnormal_response_to	1.67172176
24	MP0003718_maternal_effect	1.66053046
25	MP0008872_abnormal_physiological_respon	1.64058682
26	MP0003786_premature_aging	1.62778367
27	MP0008995_early_reproductive_senescence	1.61329406
28	MP0003011_delayed_dark_adaptation	1.57512534
29	MP0006276_abnormal_autonomic_nervous	1.52864181
30	MP0002653_abnormal_ependyma_morphology	1.43084225
31	MP0001905_abnormal_dopamine_level	1.41940996
32	MP0001764_abnormal_homeostasis	1.37993661
33	MP0003787_abnormal_imprinting	1.29223618
34	MP0002638_abnormal_pupillary_reflex	1.27872095
35	MP0009697_abnormal_copulation	1.27745838
36	MP0006036_abnormal_mitochondrial_physio	1.25240576
37	MP0002148_abnormal_hypersensitivity_rea	1.25075662
38	MP0002735_abnormal_chemical_nociception	1.24582621
39	MP0005167_abnormal_blood-brain_barrier	1.23689697
40	MP0002733_abnormal_thermal_nociception	1.20273828
41	MP0008789_abnormal_olfactory_epithelium	1.19465888
42	MP0001529_abnormal_vocalization	1.19189571
43	MP0005174_abnormal_tail_pigmentation	1.17599885
44	MP0009764_decreased_sensitivity_to	1.17026594
45	MP0001545_abnormal_hematopoietic_system	1.16153875
46	MP0005397_hematopoietic_system_phenotyp	1.16153875
47	MP0006292_abnormal_olfactory_placode	1.15380367
48	MP0009046_muscle_twitch	1.15058316
49	MP0000427_abnormal_hair_cycle	1.14336050
50	MP0001929_abnormal_gametogenesis	1.12216697
51	MP0002876_abnormal_thyroid_physiology	1.12112912
52	MP0004043_abnormal_pH_regulation	1.12080281
53	MP0009745_abnormal_behavioral_response	1.11672051
54	MP0003698_abnormal_male_reproductive	1.11066397
55	MP0000465_gastrointestinal_hemorrhage	1.08060771
56	MP0001800_abnormal_humoral_immune	1.06377356
57	MP0003186_abnormal_redox_activity	1.05452949
58	MP0002138_abnormal_hepatobiliary_system	1.02898472
59	MP0002272_abnormal_nervous_system	1.02366928
60	MP0009278_abnormal_bone_marrow	1.01770623
61	MP0002095_abnormal_skin_pigmentation	1.00944652
62	MP0002166_altered_tumor_susceptibility	1.00115517
63	MP0002909_abnormal_adrenal_gland	0.97519783
64	MP0003646_muscle_fatigue	0.95423466
65	MP0009785_altered_susceptibility_to	0.94073631
66	MP0005084_abnormal_gallbladder_morpholo	0.93767022
67	MP0000015_abnormal_ear_pigmentation	0.91837682
68	MP0002572_abnormal_emotion/affect_behav	0.91823388
69	MP0002751_abnormal_autonomic_nervous	0.89037945
70	MP0010094_abnormal_chromosome_stability	0.88599452
71	MP0002234_abnormal_pharynx_morphology	0.88412699
72	MP0002723_abnormal_immune_serum	0.88051106
73	MP0008775_abnormal_heart_ventricle	0.87701068
74	MP0005636_abnormal_mineral_homeostasis	0.86648871
75	MP0002006_tumorigenesis	0.85438919
76	MP0000631_abnormal_neuroendocrine_gland	0.85296580
77	MP0001486_abnormal_startle_reflex	0.84836282
78	MP0005332_abnormal_amino_acid	0.84115820
79	MP0001970_abnormal_pain_threshold	0.81819196
80	MP0008873_increased_physiological_sensi	0.81675516
81	MP0010329_abnormal_lipoprotein_level	0.80014591
82	MP0003724_increased_susceptibility_to	0.79241594
83	MP0005220_abnormal_exocrine_pancreas	0.78749161
84	MP0002420_abnormal_adaptive_immunity	0.77350106
85	MP0005389_reproductive_system_phenotype	0.76973880
86	MP0002452_abnormal_antigen_presenting	0.76458786
87	MP0000653_abnormal_sex_gland	0.75748193
88	MP0009765_abnormal_xenobiotic_induced	0.75705800
89	MP0001819_abnormal_immune_cell	0.75360942
90	MP0004924_abnormal_behavior	0.75267042
91	MP0005386_behavior/neurological_phenoty	0.75267042
92	MP0005000_abnormal_immune_tolerance	0.75174482
93	MP0000230_abnormal_systemic_arterial	0.74362161
94	MP0004133_heterotaxia	0.73613446
95	MP0003638_abnormal_response/metabolism_	0.72753500
96	MP0002822_catalepsy	0.70860246
97	MP0002837_dystrophic_cardiac_calcinosis	0.70146021
98	MP0002210_abnormal_sex_determination	0.68767915
99	MP0001502_abnormal_circadian_rhythm	0.68498308
100	MP0004142_abnormal_muscle_tone	0.67825867

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.48127819
2	Pancreatic fibrosis (HP:0100732)	3.28139683
3	Nephronophthisis (HP:0000090)	3.23487790
4	Abnormality of the renal cortex (HP:0011035)	3.21146829
5	Congenital stationary night blindness (HP:0007642)	3.19473301
6	Renal cortical cysts (HP:0000803)	3.12505627
7	Molar tooth sign on MRI (HP:0002419)	3.03095596
8	Abnormality of midbrain morphology (HP:0002418)	3.03095596
9	Abnormality of the renal medulla (HP:0100957)	2.99840021
10	Medial flaring of the eyebrow (HP:0010747)	2.96411162
11	True hermaphroditism (HP:0010459)	2.90107755
12	Attenuation of retinal blood vessels (HP:0007843)	2.88161235
13	Tubulointerstitial nephritis (HP:0001970)	2.85950490
14	Mitochondrial inheritance (HP:0001427)	2.85683645
15	3-Methylglutaconic aciduria (HP:0003535)	2.84246800
16	Hepatocellular necrosis (HP:0001404)	2.82903519
17	Type I transferrin isoform profile (HP:0003642)	2.82426606
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.81397848
19	Increased CSF lactate (HP:0002490)	2.80807047
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.79360282
21	Abolished electroretinogram (ERG) (HP:0000550)	2.77596398
22	Decreased central vision (HP:0007663)	2.70574403
23	Panhypogammaglobulinemia (HP:0003139)	2.67539380
24	Bile duct proliferation (HP:0001408)	2.67463118
25	Abnormal biliary tract physiology (HP:0012439)	2.67463118
26	Severe combined immunodeficiency (HP:0004430)	2.66739272
27	Abnormal protein glycosylation (HP:0012346)	2.66613292
28	Abnormal glycosylation (HP:0012345)	2.66613292
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.66613292
30	Abnormal protein N-linked glycosylation (HP:0012347)	2.66613292
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.63361989
32	Acute necrotizing encephalopathy (HP:0006965)	2.61490962
33	Agammaglobulinemia (HP:0004432)	2.59824384
34	Hepatic necrosis (HP:0002605)	2.57867155
35	Increased corneal curvature (HP:0100692)	2.57396416
36	Keratoconus (HP:0000563)	2.57396416
37	Hypoproteinemia (HP:0003075)	2.56667828
38	Thyroiditis (HP:0100646)	2.54670627
39	Abnormality of the prostate (HP:0008775)	2.48991039
40	Abnormality of B cell number (HP:0010975)	2.45695406
41	Chronic hepatic failure (HP:0100626)	2.45690298
42	Acute encephalopathy (HP:0006846)	2.38695194
43	Type II lissencephaly (HP:0007260)	2.36305577
44	Progressive inability to walk (HP:0002505)	2.33840458
45	Progressive macrocephaly (HP:0004481)	2.33768442
46	Increased intramyocellular lipid droplets (HP:0012240)	2.27561405
47	Stomach cancer (HP:0012126)	2.26780659
48	Elevated erythrocyte sedimentation rate (HP:0003565)	2.26053316
49	Pendular nystagmus (HP:0012043)	2.24755543
50	Methylmalonic aciduria (HP:0012120)	2.23528982
51	Ketosis (HP:0001946)	2.23285399
52	Progressive microcephaly (HP:0000253)	2.23256633
53	Hemiparesis (HP:0001269)	2.23193441
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20991868
55	Dicarboxylic aciduria (HP:0003215)	2.20739092
56	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.20739092
57	Cystic liver disease (HP:0006706)	2.17688130
58	Hyperglycinuria (HP:0003108)	2.16737696
59	Increased serum lactate (HP:0002151)	2.16201139
60	Polydipsia (HP:0001959)	2.16110264
61	Abnormal drinking behavior (HP:0030082)	2.16110264
62	Hypothermia (HP:0002045)	2.15986834
63	Tubulointerstitial abnormality (HP:0001969)	2.15416858
64	Lactic acidosis (HP:0003128)	2.12089151
65	Methylmalonic acidemia (HP:0002912)	2.08203205
66	Congenital primary aphakia (HP:0007707)	2.08038278
67	Inability to walk (HP:0002540)	2.07950019
68	Nephrogenic diabetes insipidus (HP:0009806)	2.07207900
69	Increased muscle lipid content (HP:0009058)	2.06911528
70	Congenital hepatic fibrosis (HP:0002612)	2.06426923
71	Gait imbalance (HP:0002141)	2.05039678
72	Cerebral edema (HP:0002181)	2.03568301
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03326352
74	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03326352
75	Ketoacidosis (HP:0001993)	2.00700806
76	Focal motor seizures (HP:0011153)	2.00692294
77	Lipid accumulation in hepatocytes (HP:0006561)	2.00578817
78	Hyperventilation (HP:0002883)	1.99762466
79	Absent speech (HP:0001344)	1.99511973
80	Optic disc pallor (HP:0000543)	1.99099230
81	Abnormality of eosinophils (HP:0001879)	1.97826018
82	Stomatitis (HP:0010280)	1.97638030
83	IgG deficiency (HP:0004315)	1.96489445
84	Eosinophilia (HP:0001880)	1.96124239
85	Retinal dysplasia (HP:0007973)	1.91872522
86	Granulocytopenia (HP:0001913)	1.86269557
87	Postaxial foot polydactyly (HP:0001830)	1.86159060
88	Lissencephaly (HP:0001339)	1.85555848
89	Tubular atrophy (HP:0000092)	1.85265867
90	Combined immunodeficiency (HP:0005387)	1.83102673
91	Abnormality of lateral ventricle (HP:0030047)	1.81448451
92	Opisthotonus (HP:0002179)	1.80418025
93	Fair hair (HP:0002286)	1.78294510
94	Abnormality of T cell physiology (HP:0011840)	1.78187892
95	Increased hepatocellular lipid droplets (HP:0006565)	1.77911252
96	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.77504843
97	B lymphocytopenia (HP:0010976)	1.76370569
98	Macular degeneration (HP:0000608)	1.75778703
99	Lethargy (HP:0001254)	1.75135625
100	Abnormality of glycine metabolism (HP:0010895)	1.73381493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.05993030
2	FRK	3.88379403
3	BCKDK	3.56561281
4	TAOK3	2.86679628
5	BMPR1B	2.61499706
6	ZAK	2.31263605
7	NUAK1	2.28198119
8	TXK	2.26690099
9	ADRBK2	2.20606199
10	GRK1	2.06255527
11	TRIM28	2.02818636
12	PINK1	1.99868014
13	VRK2	1.99078349
14	KIT	1.98522770
15	KDR	1.79896037
16	WNK3	1.73562279
17	TLK1	1.66121456
18	WNK4	1.57901125
19	EIF2AK3	1.57855365
20	PLK2	1.50333425
21	INSRR	1.47564610
22	MAPK13	1.42711012
23	VRK1	1.41518523
24	CSNK1G3	1.31948837
25	BCR	1.30668185
26	OXSR1	1.21727792
27	FLT3	1.17179918
28	CSNK1A1L	1.10832786
29	TESK2	1.08292318
30	BMPR2	1.07436830
31	DAPK2	1.06376885
32	NME1	1.05790776
33	MUSK	1.04602103
34	FES	1.04247409
35	IKBKB	1.02535717
36	PLK4	1.01900639
37	MAP4K1	0.99746994
38	CSNK1G1	0.99459728
39	SYK	0.99058311
40	TEC	0.97200256
41	MAP3K4	0.96662381
42	CLK1	0.96519971
43	PRKCE	0.94618444
44	CSNK1G2	0.93530429
45	CCNB1	0.92286911
46	ITK	0.91367694
47	ATR	0.86127934
48	PHKG1	0.83365533
49	PHKG2	0.83365533
50	MST4	0.82525860
51	ERBB3	0.82004165
52	RPS6KA4	0.80382084
53	CDK8	0.80046015
54	PIK3CA	0.79578367
55	PDK2	0.79201804
56	STK39	0.77328205
57	MATK	0.77038003
58	RPS6KA5	0.75871777
59	MAPKAPK3	0.75780120
60	PTK2B	0.75151651
61	GRK6	0.74664894
62	DAPK1	0.73160398
63	SRPK1	0.72402147
64	MAP2K7	0.67144404
65	LYN	0.66004557
66	TGFBR1	0.65265300
67	TIE1	0.61809584
68	TBK1	0.61201261
69	IKBKE	0.60670455
70	PRKCQ	0.59724057
71	LCK	0.58578383
72	PIM2	0.58023953
73	DYRK2	0.56995466
74	ADRBK1	0.56034658
75	IGF1R	0.54906347
76	CSF1R	0.54803088
77	PLK3	0.54440855
78	MARK1	0.49641227
79	TNK2	0.49103048
80	MAP2K6	0.48609714
81	MAPKAPK5	0.47115336
82	STK16	0.46708150
83	CSNK1A1	0.45964822
84	EPHA4	0.44767148
85	MAPK11	0.44485692
86	GRK5	0.44330579
87	PRKCG	0.42279974
88	ABL1	0.41638023
89	PRKCA	0.40671638
90	PRKACA	0.39574322
91	ATM	0.38189819
92	MAP2K2	0.37652344
93	CDK3	0.37608008
94	PRKCI	0.35843593
95	PKN1	0.35219936
96	ABL2	0.34880278
97	JAK3	0.33643037
98	ERBB2	0.33613203
99	CHUK	0.33244752
100	CSNK1D	0.33093569

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.19772898
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.71065568
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67580701
4	Caffeine metabolism_Homo sapiens_hsa00232	2.59358602
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57652675
6	Allograft rejection_Homo sapiens_hsa05330	2.41610695
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.40333010
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.31116977
9	Phototransduction_Homo sapiens_hsa04744	2.28598194
10	Proteasome_Homo sapiens_hsa03050	2.28201137
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.28168089
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.23827998
13	Primary immunodeficiency_Homo sapiens_hsa05340	2.13060493
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90609174
15	Butanoate metabolism_Homo sapiens_hsa00650	1.84836385
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84266319
17	RNA polymerase_Homo sapiens_hsa03020	1.81125971
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76741665
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.75311837
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.74225148
21	Base excision repair_Homo sapiens_hsa03410	1.70863014
22	Homologous recombination_Homo sapiens_hsa03440	1.63921858
23	Parkinsons disease_Homo sapiens_hsa05012	1.58502957
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.54577653
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54284075
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49680549
27	Peroxisome_Homo sapiens_hsa04146	1.46999431
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.42990370
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.40894045
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.39121751
31	Protein export_Homo sapiens_hsa03060	1.32332761
32	Fatty acid elongation_Homo sapiens_hsa00062	1.31065599
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.26442335
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.25421186
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24178589
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.24164320
37	Propanoate metabolism_Homo sapiens_hsa00640	1.20493913
38	RNA degradation_Homo sapiens_hsa03018	1.16274836
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13698311
40	Olfactory transduction_Homo sapiens_hsa04740	1.13697076
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11462071
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.09411039
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06422271
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05905491
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03417375
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00421627
47	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00185740
48	Purine metabolism_Homo sapiens_hsa00230	0.98473434
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96645530
50	Basal transcription factors_Homo sapiens_hsa03022	0.96580114
51	One carbon pool by folate_Homo sapiens_hsa00670	0.96385052
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92714313
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90103740
54	Huntingtons disease_Homo sapiens_hsa05016	0.88110800
55	Viral myocarditis_Homo sapiens_hsa05416	0.86476039
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86208093
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83955953
58	Regulation of autophagy_Homo sapiens_hsa04140	0.82192737
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.77921878
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.75637743
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73582878
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71706575
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69584421
64	Alzheimers disease_Homo sapiens_hsa05010	0.69517973
65	Metabolic pathways_Homo sapiens_hsa01100	0.68455293
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66749029
67	Fatty acid degradation_Homo sapiens_hsa00071	0.66091293
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65681539
69	Oocyte meiosis_Homo sapiens_hsa04114	0.65635533
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.65333366
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64764503
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63617818
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61774666
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61212404
75	Retinol metabolism_Homo sapiens_hsa00830	0.59716038
76	DNA replication_Homo sapiens_hsa03030	0.56797322
77	Taste transduction_Homo sapiens_hsa04742	0.55898478
78	Histidine metabolism_Homo sapiens_hsa00340	0.55585550
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.55235941
80	Mismatch repair_Homo sapiens_hsa03430	0.54867935
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52183506
82	ABC transporters_Homo sapiens_hsa02010	0.52051680
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48757674
84	Salivary secretion_Homo sapiens_hsa04970	0.45953958
85	RNA transport_Homo sapiens_hsa03013	0.44771327
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44533000
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43625715
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43034140
89	Herpes simplex infection_Homo sapiens_hsa05168	0.42841482
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39584727
91	Spliceosome_Homo sapiens_hsa03040	0.39515863
92	Sulfur metabolism_Homo sapiens_hsa00920	0.38236126
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37891759
94	Nicotine addiction_Homo sapiens_hsa05033	0.37726868
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36820942
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36457205
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36100902
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34370939
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32451391
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30268978

SPDYE21P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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