ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adaptation of signaling pathway (GO:0023058)	5.97820877
2	cornea development in camera-type eye (GO:0061303)	5.46947896
3	hindbrain development (GO:0030902)	5.32680605
4	positive thymic T cell selection (GO:0045059)	4.60559171
5	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.19893009
6	microtubule depolymerization (GO:0007019)	4.07734934
7	negative regulation of interleukin-1 beta production (GO:0032691)	3.95741518
8	regulation of glycogen (starch) synthase activity (GO:2000465)	3.94032247
9	ribonucleoprotein complex disassembly (GO:0032988)	3.91840574
10	aspartate family amino acid catabolic process (GO:0009068)	3.89629009
11	neuromuscular synaptic transmission (GO:0007274)	3.85667936
12	cilium or flagellum-dependent cell motility (GO:0001539)	3.84893229
13	DNA double-strand break processing (GO:0000729)	3.76994247
14	regulation of DNA endoreduplication (GO:0032875)	3.68037109
15	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.67908244
16	indolalkylamine metabolic process (GO:0006586)	3.59387946
17	lysine metabolic process (GO:0006553)	3.57938949
18	lysine catabolic process (GO:0006554)	3.57938949
19	neurotransmitter biosynthetic process (GO:0042136)	3.54462038
20	tryptophan metabolic process (GO:0006568)	3.54376209
21	auditory receptor cell stereocilium organization (GO:0060088)	3.53361174
22	S-adenosylmethionine metabolic process (GO:0046500)	3.47756386
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.47206576
24	L-methionine salvage (GO:0071267)	3.45856236
25	L-methionine biosynthetic process (GO:0071265)	3.45856236
26	amino acid salvage (GO:0043102)	3.45856236
27	maturation of 5.8S rRNA (GO:0000460)	3.43582940
28	cellular response to ATP (GO:0071318)	3.41265654
29	DNA catabolic process, exonucleolytic (GO:0000738)	3.40518249
30	ubiquinone biosynthetic process (GO:0006744)	3.40492053
31	axonemal dynein complex assembly (GO:0070286)	3.39692277
32	neurotransmitter metabolic process (GO:0042133)	3.39183916
33	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.38639123
34	prenylation (GO:0097354)	3.37526869
35	protein prenylation (GO:0018342)	3.37526869
36	negative regulation of interleukin-1 production (GO:0032692)	3.33698177
37	detection of light stimulus involved in sensory perception (GO:0050962)	3.32528193
38	detection of light stimulus involved in visual perception (GO:0050908)	3.32528193
39	growth hormone receptor signaling pathway (GO:0060396)	3.32039365
40	protein polyglutamylation (GO:0018095)	3.27093882
41	platelet dense granule organization (GO:0060155)	3.25721109
42	adult feeding behavior (GO:0008343)	3.24448152
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.13271801
44	meiotic chromosome segregation (GO:0045132)	3.12693516
45	positive regulation of fatty acid transport (GO:2000193)	3.11528084
46	rRNA catabolic process (GO:0016075)	3.11396430
47	positive T cell selection (GO:0043368)	3.09678558
48	intestinal epithelial cell development (GO:0060576)	3.07060326
49	inner ear receptor stereocilium organization (GO:0060122)	3.01405286
50	ubiquinone metabolic process (GO:0006743)	3.00934194
51	artery development (GO:0060840)	3.00751049
52	N-acetylglucosamine metabolic process (GO:0006044)	2.98068508
53	positive regulation of icosanoid secretion (GO:0032305)	2.96746003
54	regulation of meiosis I (GO:0060631)	2.96717070
55	microtubule severing (GO:0051013)	2.95564676
56	methionine biosynthetic process (GO:0009086)	2.95102745
57	regulation of cilium movement (GO:0003352)	2.94880499
58	cellular response to growth hormone stimulus (GO:0071378)	2.91996651
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90717586
60	positive regulation of CREB transcription factor activity (GO:0032793)	2.90682572
61	organ formation (GO:0048645)	2.90592633
62	male meiosis (GO:0007140)	2.88433124
63	anterograde synaptic vesicle transport (GO:0048490)	2.88207988
64	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.87910627
65	spinal cord development (GO:0021510)	2.87057844
66	respiratory chain complex IV assembly (GO:0008535)	2.86457517
67	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.83548795
68	regulation of appetite (GO:0032098)	2.79662068
69	regulation of response to food (GO:0032095)	2.79661572
70	positive regulation of prostaglandin secretion (GO:0032308)	2.76967232
71	fucose catabolic process (GO:0019317)	2.76016919
72	L-fucose metabolic process (GO:0042354)	2.76016919
73	L-fucose catabolic process (GO:0042355)	2.76016919
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74953759
75	peptidyl-lysine dimethylation (GO:0018027)	2.73103171
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.72603207
77	cytochrome complex assembly (GO:0017004)	2.69234934
78	double-strand break repair via homologous recombination (GO:0000724)	2.68533000
79	microtubule polymerization or depolymerization (GO:0031109)	2.68004022
80	multicellular organism reproduction (GO:0032504)	2.66788575
81	retinal cone cell development (GO:0046549)	2.66676926
82	recombinational repair (GO:0000725)	2.66629113
83	behavioral response to nicotine (GO:0035095)	2.66617504
84	axoneme assembly (GO:0035082)	2.66480500
85	anterograde axon cargo transport (GO:0008089)	2.64753798
86	neural tube formation (GO:0001841)	2.64187480
87	epithelial cilium movement (GO:0003351)	2.61592292
88	cilium organization (GO:0044782)	2.61549285
89	quinone biosynthetic process (GO:1901663)	2.60823961
90	mitotic sister chromatid segregation (GO:0000070)	2.59317882
91	intraciliary transport (GO:0042073)	2.58201688
92	DNA replication-dependent nucleosome assembly (GO:0006335)	2.57649492
93	DNA replication-dependent nucleosome organization (GO:0034723)	2.57649492
94	positive regulation of organic acid transport (GO:0032892)	2.57209626
95	motile cilium assembly (GO:0044458)	2.55523884
96	response to food (GO:0032094)	2.54554770
97	lymphoid progenitor cell differentiation (GO:0002320)	2.52053200
98	regulation of histone phosphorylation (GO:0033127)	2.51785817
99	negative regulation of muscle hypertrophy (GO:0014741)	2.50380597
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48838170

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04722373
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.61299724
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.30568531
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.24785675
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76900425
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63684917
7	EWS_26573619_Chip-Seq_HEK293_Human	2.59767950
8	MYC_18940864_ChIP-ChIP_HL60_Human	2.47761992
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28391957
10	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.21488927
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13862882
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09327940
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08771470
14	VDR_22108803_ChIP-Seq_LS180_Human	2.08303343
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.97826965
16	FUS_26573619_Chip-Seq_HEK293_Human	1.97797587
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96912450
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96521484
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96222998
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92270440
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.92259555
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.89685308
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87822437
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84939500
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.77354610
26	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.77081108
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.74882135
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.72943235
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.71805893
30	P300_19829295_ChIP-Seq_ESCs_Human	1.71112706
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64628472
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.60001650
33	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.54735077
34	AR_20517297_ChIP-Seq_VCAP_Human	1.53259897
35	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.53149563
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.52342404
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52226560
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49845560
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45082957
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45082957
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44016116
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.41509938
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.40658771
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40658771
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39958570
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38427543
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36336507
48	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.36058934
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35444208
50	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.28470715
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28449543
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26893123
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26893123
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25585250
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24685829
56	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.22592694
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.20953307
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20005423
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18907159
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.18125136
61	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.16438059
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13963479
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13793271
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.12237766
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.10438560
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10389828
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10294554
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08965980
69	TCF4_23295773_ChIP-Seq_U87_Human	1.08694566
70	EZH2_22144423_ChIP-Seq_EOC_Human	1.07364191
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06904248
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05434897
73	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.02026167
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01571177
75	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01488211
76	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01146631
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00506090
78	GATA3_26560356_Chip-Seq_TH2_Human	1.00145315
79	ERA_21632823_ChIP-Seq_H3396_Human	0.99972294
80	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99953101
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97929583
82	STAT3_23295773_ChIP-Seq_U87_Human	0.97289499
83	AR_25329375_ChIP-Seq_VCAP_Human	0.97252747
84	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96953529
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96750551
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95928492
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95540183
88	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.94853212
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.94780030
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94353456
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.92345981
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92217293
93	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.91997254
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91752552
95	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.91252847
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91060888
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89516722
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.89115417
99	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.88495244
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88365726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	7.44619243
2	MP0009780_abnormal_chondrocyte_physiolo	4.61451726
3	MP0005167_abnormal_blood-brain_barrier	3.13511585
4	MP0001661_extended_life_span	2.68951995
5	MP0002653_abnormal_ependyma_morphology	2.30390935
6	MP0006072_abnormal_retinal_apoptosis	2.28339023
7	MP0005220_abnormal_exocrine_pancreas	2.19489951
8	MP0002102_abnormal_ear_morphology	2.17911643
9	MP0000383_abnormal_hair_follicle	2.13283319
10	MP0008872_abnormal_physiological_respon	2.08681008
11	MP0010386_abnormal_urinary_bladder	2.05496392
12	MP0002837_dystrophic_cardiac_calcinosis	2.04498625
13	MP0004147_increased_porphyrin_level	2.02285712
14	MP0004142_abnormal_muscle_tone	2.01818291
15	MP0002638_abnormal_pupillary_reflex	2.01091750
16	MP0005076_abnormal_cell_differentiation	1.90053503
17	MP0002282_abnormal_trachea_morphology	1.89220716
18	MP0003119_abnormal_digestive_system	1.80555055
19	MP0006292_abnormal_olfactory_placode	1.73041794
20	MP0000372_irregular_coat_pigmentation	1.72004509
21	MP0005253_abnormal_eye_physiology	1.71505050
22	MP0002138_abnormal_hepatobiliary_system	1.70018423
23	MP0002269_muscular_atrophy	1.69167531
24	MP0005551_abnormal_eye_electrophysiolog	1.59409213
25	MP0002751_abnormal_autonomic_nervous	1.55983830
26	MP0003136_yellow_coat_color	1.52999698
27	MP0010094_abnormal_chromosome_stability	1.51936723
28	MP0008058_abnormal_DNA_repair	1.50320562
29	MP0000538_abnormal_urinary_bladder	1.49677339
30	MP0002938_white_spotting	1.48584450
31	MP0003011_delayed_dark_adaptation	1.45520239
32	MP0002735_abnormal_chemical_nociception	1.44005605
33	MP0002108_abnormal_muscle_morphology	1.41873660
34	MP0004742_abnormal_vestibular_system	1.37582524
35	MP0000537_abnormal_urethra_morphology	1.34800191
36	MP0003724_increased_susceptibility_to	1.33864491
37	MP0005083_abnormal_biliary_tract	1.31792891
38	MP0001486_abnormal_startle_reflex	1.31296609
39	MP0001986_abnormal_taste_sensitivity	1.31144021
40	MP0004134_abnormal_chest_morphology	1.28587288
41	MP0005187_abnormal_penis_morphology	1.23252202
42	MP0002909_abnormal_adrenal_gland	1.20841346
43	MP0001529_abnormal_vocalization	1.19058375
44	MP0001324_abnormal_eye_pigmentation	1.18285937
45	MP0003111_abnormal_nucleus_morphology	1.17721342
46	MP0004233_abnormal_muscle_weight	1.13768518
47	MP0004808_abnormal_hematopoietic_stem	1.12583518
48	MP0003959_abnormal_lean_body	1.12112780
49	MP0002234_abnormal_pharynx_morphology	1.09018322
50	MP0004133_heterotaxia	1.08819586
51	MP0001293_anophthalmia	1.08426818
52	MP0001502_abnormal_circadian_rhythm	1.07577387
53	MP0005171_absent_coat_pigmentation	1.03262007
54	MP0001968_abnormal_touch/_nociception	1.02983407
55	MP0002557_abnormal_social/conspecific_i	1.01830009
56	MP0000470_abnormal_stomach_morphology	0.98973462
57	MP0002272_abnormal_nervous_system	0.98860113
58	MP0004130_abnormal_muscle_cell	0.98591842
59	MP0010678_abnormal_skin_adnexa	0.97774088
60	MP0004924_abnormal_behavior	0.97086899
61	MP0005386_behavior/neurological_phenoty	0.97086899
62	MP0003880_abnormal_central_pattern	0.95601964
63	MP0003786_premature_aging	0.94844510
64	MP0009046_muscle_twitch	0.91235106
65	MP0001485_abnormal_pinna_reflex	0.91207392
66	MP0002184_abnormal_innervation	0.90389233
67	MP0001929_abnormal_gametogenesis	0.89433429
68	MP0003195_calcinosis	0.88299406
69	MP0009278_abnormal_bone_marrow	0.87467180
70	MP0009745_abnormal_behavioral_response	0.86815504
71	MP0002067_abnormal_sensory_capabilities	0.84609785
72	MP0003638_abnormal_response/metabolism_	0.84604566
73	MP0000013_abnormal_adipose_tissue	0.84269993
74	MP0008775_abnormal_heart_ventricle	0.83569818
75	MP0008007_abnormal_cellular_replicative	0.81400374
76	MP0005381_digestive/alimentary_phenotyp	0.80026692
77	MP0003698_abnormal_male_reproductive	0.77382494
78	MP0001663_abnormal_digestive_system	0.76870928
79	MP0003137_abnormal_impulse_conducting	0.76763811
80	MP0001501_abnormal_sleep_pattern	0.75791170
81	MP0005646_abnormal_pituitary_gland	0.75299625
82	MP0002210_abnormal_sex_determination	0.75295775
83	MP0008995_early_reproductive_senescence	0.74488326
84	MP0005332_abnormal_amino_acid	0.74299697
85	MP0002752_abnormal_somatic_nervous	0.73111435
86	MP0009697_abnormal_copulation	0.71659098
87	MP0000427_abnormal_hair_cycle	0.71528247
88	MP0001533_abnormal_skeleton_physiology	0.70823989
89	MP0003878_abnormal_ear_physiology	0.70395600
90	MP0005377_hearing/vestibular/ear_phenot	0.70395600
91	MP0002111_abnormal_tail_morphology	0.69215792
92	MP0003718_maternal_effect	0.66183720
93	MP0003868_abnormal_feces_composition	0.64130190
94	MP0001664_abnormal_digestion	0.64045377
95	MP0008877_abnormal_DNA_methylation	0.63753879
96	MP0000955_abnormal_spinal_cord	0.62097749
97	MP0002736_abnormal_nociception_after	0.61008275
98	MP0005391_vision/eye_phenotype	0.58500126
99	MP0000579_abnormal_nail_morphology	0.56995953
100	MP0002572_abnormal_emotion/affect_behav	0.56022966

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	6.00761181
2	Muscle fiber atrophy (HP:0100295)	4.98552147
3	Congenital, generalized hypertrichosis (HP:0004540)	4.15288913
4	Fatigable weakness (HP:0003473)	4.09530506
5	Abnormality of the neuromuscular junction (HP:0003398)	4.09530506
6	Type II lissencephaly (HP:0007260)	3.93357497
7	Pancreatic fibrosis (HP:0100732)	3.56675566
8	Pancreatic cysts (HP:0001737)	3.47096346
9	Nephronophthisis (HP:0000090)	3.44716405
10	Abnormality of lateral ventricle (HP:0030047)	3.26278496
11	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.25364605
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.25364605
13	Disproportionate short-trunk short stature (HP:0003521)	3.18419964
14	Volvulus (HP:0002580)	3.13905221
15	Weak cry (HP:0001612)	3.13258563
16	Tubular atrophy (HP:0000092)	3.06996622
17	Absent/shortened dynein arms (HP:0200106)	3.06049386
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.06049386
19	True hermaphroditism (HP:0010459)	3.04462321
20	Birth length less than 3rd percentile (HP:0003561)	3.04265505
21	Decreased central vision (HP:0007663)	2.96830011
22	Molar tooth sign on MRI (HP:0002419)	2.91915791
23	Abnormality of midbrain morphology (HP:0002418)	2.91915791
24	Lissencephaly (HP:0001339)	2.84634815
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.82522466
26	Abnormality of the renal medulla (HP:0100957)	2.81673764
27	Genetic anticipation (HP:0003743)	2.80430614
28	Attenuation of retinal blood vessels (HP:0007843)	2.75779235
29	Biliary tract neoplasm (HP:0100574)	2.72266689
30	Cerebellar dysplasia (HP:0007033)	2.69788349
31	Increased corneal curvature (HP:0100692)	2.66599394
32	Keratoconus (HP:0000563)	2.66599394
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.65407635
34	Back pain (HP:0003418)	2.55095582
35	Global brain atrophy (HP:0002283)	2.54399988
36	Pachygyria (HP:0001302)	2.52885281
37	Tubulointerstitial fibrosis (HP:0005576)	2.51797403
38	Constricted visual fields (HP:0001133)	2.51523854
39	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.51027717
40	Panhypogammaglobulinemia (HP:0003139)	2.50570866
41	Poor suck (HP:0002033)	2.49945615
42	Respiratory distress (HP:0002098)	2.43607035
43	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.41278036
44	Progressive inability to walk (HP:0002505)	2.40246605
45	Abnormality of the renal cortex (HP:0011035)	2.37166507
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.33209197
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33209197
48	Hyperglycinuria (HP:0003108)	2.29026755
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24220136
50	Rib fusion (HP:0000902)	2.23074075
51	Duplicated collecting system (HP:0000081)	2.22865705
52	Cystic liver disease (HP:0006706)	2.17590315
53	Abnormality of the corticospinal tract (HP:0002492)	2.14339676
54	Postaxial foot polydactyly (HP:0001830)	2.09946482
55	Chromsome breakage (HP:0040012)	2.09507093
56	Abnormality of the ileum (HP:0001549)	2.07777742
57	Medial flaring of the eyebrow (HP:0010747)	2.07045606
58	Abnormality of the renal collecting system (HP:0004742)	2.06076477
59	Retinal dysplasia (HP:0007973)	2.05388756
60	Mesangial abnormality (HP:0001966)	2.03374230
61	Anencephaly (HP:0002323)	2.03353215
62	Inability to walk (HP:0002540)	2.02085317
63	Abnormality of alanine metabolism (HP:0010916)	2.00713846
64	Hyperalaninemia (HP:0003348)	2.00713846
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00713846
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00447002
67	Ulnar claw (HP:0001178)	1.99653359
68	Spastic tetraparesis (HP:0001285)	1.99179160
69	Congenital hepatic fibrosis (HP:0002612)	1.97973845
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.97734667
71	Meckel diverticulum (HP:0002245)	1.97547961
72	Abnormal ciliary motility (HP:0012262)	1.97420986
73	Preaxial hand polydactyly (HP:0001177)	1.96697114
74	Abnormality of the preputium (HP:0100587)	1.95793952
75	Ureteral duplication (HP:0000073)	1.95131015
76	Hydroxyprolinuria (HP:0003080)	1.94770493
77	Abnormality of proline metabolism (HP:0010907)	1.94770493
78	Congenital stationary night blindness (HP:0007642)	1.92493700
79	Patellar aplasia (HP:0006443)	1.91004543
80	Agitation (HP:0000713)	1.89327398
81	Clubbing of toes (HP:0100760)	1.87003356
82	Abnormality of serum amino acid levels (HP:0003112)	1.86062547
83	Gastrointestinal atresia (HP:0002589)	1.85099884
84	Nasal polyposis (HP:0100582)	1.84677294
85	Neoplasm of head and neck (HP:0012288)	1.84398847
86	Esophageal neoplasm (HP:0100751)	1.84398847
87	Pendular nystagmus (HP:0012043)	1.82831366
88	Tubulointerstitial abnormality (HP:0001969)	1.82635960
89	Abnormality of chromosome stability (HP:0003220)	1.82334165
90	Morphological abnormality of the pyramidal tract (HP:0002062)	1.79748500
91	Fair hair (HP:0002286)	1.79272940
92	Neoplasm of the rectum (HP:0100743)	1.79089393
93	Abnormality of the carotid arteries (HP:0005344)	1.77646218
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77104315
95	Azoospermia (HP:0000027)	1.76313589
96	Encephalitis (HP:0002383)	1.76268810
97	Small intestinal stenosis (HP:0012848)	1.74890105
98	Duodenal stenosis (HP:0100867)	1.74890105
99	Sloping forehead (HP:0000340)	1.74708788
100	3-Methylglutaconic aciduria (HP:0003535)	1.74419607

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK3	7.43175212
2	BMPR1B	5.02082571
3	CDK8	3.56166104
4	TRIM28	3.50725476
5	BCKDK	3.37711941
6	INSRR	3.10259877
7	FRK	2.94161146
8	TGFBR1	2.63536092
9	SIK1	2.58595127
10	MARK3	2.06377119
11	NEK1	1.99976419
12	WNK4	1.94883767
13	ADRBK2	1.83480831
14	WNK3	1.76147432
15	SIK2	1.68052242
16	BCR	1.52455714
17	GRK1	1.50191299
18	KSR1	1.49134081
19	MET	1.45663464
20	BUB1	1.36597358
21	TAOK3	1.31656805
22	TRPM7	1.28896132
23	PLK2	1.21079302
24	PRKCG	1.20757351
25	ZAK	1.20430427
26	MAPK13	1.12977206
27	CAMK1D	1.06226216
28	STK39	1.01099348
29	OXSR1	0.96718245
30	TLK1	0.96259758
31	WEE1	0.95977796
32	RPS6KA5	0.92602453
33	PIK3CA	0.92189979
34	PIM2	0.89710210
35	PRKCH	0.86810538
36	NEK2	0.83416996
37	CDK9	0.81535392
38	MINK1	0.80632183
39	PRKCE	0.80537855
40	PLK4	0.80535108
41	PRKCZ	0.77850742
42	RPS6KA6	0.77154819
43	RPS6KA2	0.75470784
44	ERBB4	0.75102975
45	RAF1	0.69406700
46	CAMK1G	0.68183596
47	MKNK2	0.66428518
48	MUSK	0.63345655
49	EIF2AK3	0.62203873
50	KIT	0.59568074
51	MAPKAPK3	0.59383328
52	TYRO3	0.58003594
53	ACVR1B	0.57455118
54	RPS6KL1	0.56783134
55	RPS6KC1	0.56783134
56	PINK1	0.55502566
57	MKNK1	0.55333096
58	NUAK1	0.55215648
59	VRK2	0.54372684
60	ATR	0.53673304
61	MAP2K1	0.52845908
62	ITK	0.51433997
63	PLK3	0.48920748
64	MAP4K2	0.47041792
65	ADRBK1	0.46838784
66	VRK1	0.45083860
67	MARK1	0.44212605
68	FLT3	0.42926041
69	PRKAA1	0.41246706
70	CDK3	0.40820682
71	PDK2	0.40515778
72	CAMK2A	0.40176138
73	PLK1	0.39807857
74	MST1R	0.39411095
75	NME1	0.38515595
76	FES	0.38195766
77	TEC	0.37292025
78	ERBB3	0.36774768
79	NTRK1	0.35432317
80	CSF1R	0.33226051
81	PTK2B	0.32280340
82	STK3	0.31889729
83	CDK7	0.30595397
84	ATM	0.29403472
85	PRKCD	0.28835966
86	BRSK2	0.28734951
87	IGF1R	0.28243331
88	EIF2AK2	0.25484877
89	MAPKAPK5	0.25073225
90	MAPK11	0.24966344
91	DYRK2	0.24800715
92	CDK12	0.24720947
93	PHKG2	0.24660198
94	PHKG1	0.24660198
95	NTRK3	0.24431794
96	CAMK4	0.24427427
97	CAMK2G	0.23820094
98	CDC7	0.23317402
99	TTK	0.22194584
100	TAF1	0.21994997

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.23858119
2	Butanoate metabolism_Homo sapiens_hsa00650	3.22739090
3	Homologous recombination_Homo sapiens_hsa03440	3.09011594
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.99485423
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.78101005
6	One carbon pool by folate_Homo sapiens_hsa00670	2.67177034
7	Asthma_Homo sapiens_hsa05310	2.58637051
8	Basal transcription factors_Homo sapiens_hsa03022	2.58339353
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.49585452
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.47488356
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.37276940
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36068526
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.26900361
14	Phototransduction_Homo sapiens_hsa04744	2.21324047
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00712079
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96334714
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91362173
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80464974
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.77454685
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72337460
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.71394742
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67077086
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63274344
24	Allograft rejection_Homo sapiens_hsa05330	1.61632515
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60929215
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.49143120
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44720709
28	RNA degradation_Homo sapiens_hsa03018	1.41288565
29	Mismatch repair_Homo sapiens_hsa03430	1.38159853
30	Nicotine addiction_Homo sapiens_hsa05033	1.36070405
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.24914424
32	Basal cell carcinoma_Homo sapiens_hsa05217	1.18662823
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17456998
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.17315214
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14421789
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13432342
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10340316
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.08725640
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08433487
40	Sulfur relay system_Homo sapiens_hsa04122	1.06918882
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06559083
42	Parkinsons disease_Homo sapiens_hsa05012	1.02908971
43	Huntingtons disease_Homo sapiens_hsa05016	1.00013621
44	Taste transduction_Homo sapiens_hsa04742	0.98512512
45	Lysine degradation_Homo sapiens_hsa00310	0.97694793
46	Oxidative phosphorylation_Homo sapiens_hsa00190	0.96635062
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95581244
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94382233
49	Alcoholism_Homo sapiens_hsa05034	0.94352519
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.90832891
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89427052
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88200907
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.84593613
54	Olfactory transduction_Homo sapiens_hsa04740	0.84133106
55	Mineral absorption_Homo sapiens_hsa04978	0.79006532
56	Cell cycle_Homo sapiens_hsa04110	0.78149465
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.73687920
58	RNA polymerase_Homo sapiens_hsa03020	0.73301106
59	Oocyte meiosis_Homo sapiens_hsa04114	0.73015249
60	ABC transporters_Homo sapiens_hsa02010	0.68609892
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67041032
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.66938407
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66068655
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64621534
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62319206
66	RNA transport_Homo sapiens_hsa03013	0.59711016
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59143364
68	Alzheimers disease_Homo sapiens_hsa05010	0.58604634
69	Ribosome_Homo sapiens_hsa03010	0.57910787
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57886107
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56093581
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54046256
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52422730
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52330067
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51899874
76	DNA replication_Homo sapiens_hsa03030	0.51532816
77	Protein export_Homo sapiens_hsa03060	0.50669333
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50047754
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47146452
80	Spliceosome_Homo sapiens_hsa03040	0.46899621
81	Histidine metabolism_Homo sapiens_hsa00340	0.44004155
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43682923
83	Metabolic pathways_Homo sapiens_hsa01100	0.43408188
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.43219195
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42699446
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41902558
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40875811
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.40832622
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40608585
90	Retinol metabolism_Homo sapiens_hsa00830	0.37339691
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36587021
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34730543
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33840987
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31862414
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28390538
96	Amphetamine addiction_Homo sapiens_hsa05031	0.25842087
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.24358554
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.23168736
99	Caffeine metabolism_Homo sapiens_hsa00232	0.20906345
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.19336757

SPDYE22P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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