ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	6.84754278
2	establishment of protein localization to Golgi (GO:0072600)	6.21623448
3	protein targeting to Golgi (GO:0000042)	6.17575688
4	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.82985663
5	maintenance of gastrointestinal epithelium (GO:0030277)	5.62942032
6	protein localization to Golgi apparatus (GO:0034067)	4.75361104
7	L-fucose catabolic process (GO:0042355)	4.45705365
8	fucose catabolic process (GO:0019317)	4.45705365
9	L-fucose metabolic process (GO:0042354)	4.45705365
10	multicellular organism reproduction (GO:0032504)	4.43169681
11	regulation of glucokinase activity (GO:0033131)	4.41705166
12	regulation of hexokinase activity (GO:1903299)	4.41705166
13	indole-containing compound catabolic process (GO:0042436)	4.39249020
14	indolalkylamine catabolic process (GO:0046218)	4.39249020
15	tryptophan catabolic process (GO:0006569)	4.39249020
16	kynurenine metabolic process (GO:0070189)	4.06384557
17	tryptophan metabolic process (GO:0006568)	4.02416243
18	centriole replication (GO:0007099)	4.01452830
19	positive regulation of granulocyte differentiation (GO:0030854)	3.99067568
20	mannosylation (GO:0097502)	3.88640736
21	epithelial structure maintenance (GO:0010669)	3.86460598
22	sperm motility (GO:0030317)	3.77103807
23	piRNA metabolic process (GO:0034587)	3.76109025
24	NAD biosynthetic process (GO:0009435)	3.73158486
25	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.68496432
26	regulation of ARF GTPase activity (GO:0032312)	3.63927795
27	cellular response to exogenous dsRNA (GO:0071360)	3.58698595
28	O-glycan processing (GO:0016266)	3.54782649
29	DNA methylation involved in gamete generation (GO:0043046)	3.41260041
30	rRNA catabolic process (GO:0016075)	3.34454049
31	preassembly of GPI anchor in ER membrane (GO:0016254)	3.33852107
32	regulation of MHC class I biosynthetic process (GO:0045343)	3.32105118
33	indolalkylamine metabolic process (GO:0006586)	3.31221689
34	double-strand break repair via homologous recombination (GO:0000724)	3.29537953
35	nephron epithelium morphogenesis (GO:0072088)	3.29491520
36	nephron tubule morphogenesis (GO:0072078)	3.29491520
37	intra-Golgi vesicle-mediated transport (GO:0006891)	3.26004327
38	rRNA modification (GO:0000154)	3.25809168
39	recombinational repair (GO:0000725)	3.23986126
40	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.23241770
41	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.23241770
42	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.23241770
43	acrosome reaction (GO:0007340)	3.21135681
44	rRNA methylation (GO:0031167)	3.17884377
45	replication fork processing (GO:0031297)	3.16867533
46	centriole assembly (GO:0098534)	3.16366188
47	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.15925676
48	regulation of granulocyte differentiation (GO:0030852)	3.14484768
49	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14104694
50	regulation of G0 to G1 transition (GO:0070316)	3.09958159
51	photoreceptor cell maintenance (GO:0045494)	3.08996842
52	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.07041966
53	cilium or flagellum-dependent cell motility (GO:0001539)	3.02949860
54	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.02722372
55	negative regulation of multicellular organism growth (GO:0040015)	2.98379191
56	DNA catabolic process, exonucleolytic (GO:0000738)	2.97086774
57	reproduction (GO:0000003)	2.93207100
58	spermatid development (GO:0007286)	2.91725742
59	Golgi to endosome transport (GO:0006895)	2.86321498
60	cytochrome complex assembly (GO:0017004)	2.85861421
61	fusion of sperm to egg plasma membrane (GO:0007342)	2.84075656
62	protein O-linked glycosylation (GO:0006493)	2.83930861
63	double-strand break repair via nonhomologous end joining (GO:0006303)	2.82849775
64	non-recombinational repair (GO:0000726)	2.82849775
65	protein import into peroxisome matrix (GO:0016558)	2.79245629
66	renal tubule morphogenesis (GO:0061333)	2.73715711
67	histone H3-K9 methylation (GO:0051567)	2.69860073
68	auditory receptor cell stereocilium organization (GO:0060088)	2.69375343
69	single fertilization (GO:0007338)	2.68104295
70	cellular ketone body metabolic process (GO:0046950)	2.67389738
71	mast cell degranulation (GO:0043303)	2.66575137
72	mast cell activation involved in immune response (GO:0002279)	2.66575137
73	negative regulation of mast cell activation (GO:0033004)	2.64581797
74	histone H3-K4 methylation (GO:0051568)	2.63963978
75	cellular response to ethanol (GO:0071361)	2.60648551
76	glial cell proliferation (GO:0014009)	2.59184494
77	interleukin-6-mediated signaling pathway (GO:0070102)	2.57682871
78	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.57113958
79	maturation of 5.8S rRNA (GO:0000460)	2.56314006
80	mitochondrial DNA replication (GO:0006264)	2.56076847
81	histone H3-K4 trimethylation (GO:0080182)	2.55361729
82	cellular biogenic amine catabolic process (GO:0042402)	2.54602057
83	amine catabolic process (GO:0009310)	2.54602057
84	protein polyglutamylation (GO:0018095)	2.53512943
85	transcription from mitochondrial promoter (GO:0006390)	2.50990603
86	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.50822955
87	regulation of hippo signaling (GO:0035330)	2.50125261
88	positive regulation of DNA repair (GO:0045739)	2.49438649
89	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.47416329
90	pyridine nucleotide biosynthetic process (GO:0019363)	2.47416329
91	regulation of cilium movement (GO:0003352)	2.47309975
92	brain morphogenesis (GO:0048854)	2.47222116
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.46089862
94	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.46089862
95	fucosylation (GO:0036065)	2.45992321
96	ketone body metabolic process (GO:1902224)	2.40846924
97	adaptation of signaling pathway (GO:0023058)	2.40398428
98	indole-containing compound metabolic process (GO:0042430)	2.39791060
99	regulation of acrosome reaction (GO:0060046)	2.38806415
100	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.38017043

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.66676975
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.60716835
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27470949
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.26089664
5	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.80271443
6	ER_23166858_ChIP-Seq_MCF-7_Human	2.67053144
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.59537063
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47857244
9	VDR_22108803_ChIP-Seq_LS180_Human	2.43533097
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34705446
11	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.29347471
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04908989
13	DROSHA_22980978_ChIP-Seq_HELA_Human	1.83675009
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82976919
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80197991
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.76124625
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.74918282
18	GATA3_26560356_Chip-Seq_TH2_Human	1.74166091
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.71849434
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68578812
21	FUS_26573619_Chip-Seq_HEK293_Human	1.67648566
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67575028
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66646824
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65484660
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.65309665
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64163332
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63363942
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.62605535
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.61997232
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61997232
31	RUNX_20019798_ChIP-Seq_JUKART_Human	1.57421032
32	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55122658
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48283474
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43730310
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.43699347
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.43050239
37	TCF4_23295773_ChIP-Seq_U87_Human	1.40323664
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39973148
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34413782
40	AR_25329375_ChIP-Seq_VCAP_Human	1.31799876
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30450340
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30450340
43	ERA_21632823_ChIP-Seq_H3396_Human	1.29546089
44	GATA3_27048872_Chip-Seq_THYMUS_Human	1.28187712
45	P300_19829295_ChIP-Seq_ESCs_Human	1.28142483
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28114879
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28103603
48	STAT3_23295773_ChIP-Seq_U87_Human	1.28041863
49	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.26155774
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26004731
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24948309
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.24857219
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.24801560
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23859535
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.22242566
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.18999285
57	NCOR_22424771_ChIP-Seq_293T_Human	1.17281118
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16473780
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14952016
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14847023
61	OCT4_20526341_ChIP-Seq_ESCs_Human	1.11155743
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10895549
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08152651
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08054340
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07983890
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07444974
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06862873
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06092643
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05856273
70	EWS_26573619_Chip-Seq_HEK293_Human	1.05709748
71	SCL_19346495_ChIP-Seq_HPC-7_Human	1.05705811
72	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04910785
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03651916
74	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03139900
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02950219
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01885652
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01885652
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01776130
79	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00827330
80	MYB_26560356_Chip-Seq_TH2_Human	1.00250048
81	GATA3_26560356_Chip-Seq_TH1_Human	1.00032302
82	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99555878
83	AR_20517297_ChIP-Seq_VCAP_Human	0.99491175
84	RXR_22108803_ChIP-Seq_LS180_Human	0.98937461
85	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98508248
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97530933
87	EZH2_22144423_ChIP-Seq_EOC_Human	0.97473830
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.97239595
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.96440434
90	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.95304653
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.94797361
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94205331
93	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.93705839
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93344480
95	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93318317
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92975386
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92855631
98	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92605479
99	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.92591344
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92486110

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000465_gastrointestinal_hemorrhage	3.38058961
2	MP0008004_abnormal_stomach_pH	2.86087543
3	MP0003195_calcinosis	2.76030241
4	MP0008058_abnormal_DNA_repair	2.63763584
5	MP0010094_abnormal_chromosome_stability	2.61795851
6	MP0005410_abnormal_fertilization	2.57162070
7	MP0004043_abnormal_pH_regulation	2.48346410
8	MP0003866_abnormal_defecation	2.40508722
9	MP0005551_abnormal_eye_electrophysiolog	2.19759613
10	MP0001485_abnormal_pinna_reflex	1.96067502
11	MP0008995_early_reproductive_senescence	1.89231499
12	MP0005220_abnormal_exocrine_pancreas	1.87571179
13	MP0008057_abnormal_DNA_replication	1.84008980
14	MP0006072_abnormal_retinal_apoptosis	1.83762297
15	MP0000427_abnormal_hair_cycle	1.82221935
16	MP0005310_abnormal_salivary_gland	1.79955131
17	MP0003786_premature_aging	1.73467587
18	MP0008875_abnormal_xenobiotic_pharmacok	1.70891028
19	MP0000538_abnormal_urinary_bladder	1.70873109
20	MP0005671_abnormal_response_to	1.69110262
21	MP0001835_abnormal_antigen_presentation	1.68623654
22	MP0004147_increased_porphyrin_level	1.64130682
23	MP0001666_abnormal_nutrient_absorption	1.62899104
24	MP0001765_abnormal_ion_homeostasis	1.57090146
25	MP0005253_abnormal_eye_physiology	1.55051995
26	MP0003763_abnormal_thymus_physiology	1.53667107
27	MP0008872_abnormal_physiological_respon	1.52449470
28	MP0002166_altered_tumor_susceptibility	1.50599386
29	MP0001984_abnormal_olfaction	1.50471422
30	MP0010307_abnormal_tumor_latency	1.47895553
31	MP0003806_abnormal_nucleotide_metabolis	1.45156124
32	MP0004145_abnormal_muscle_electrophysio	1.39538676
33	MP0010155_abnormal_intestine_physiology	1.38969919
34	MP0002138_abnormal_hepatobiliary_system	1.36538700
35	MP0003698_abnormal_male_reproductive	1.36473145
36	MP0001968_abnormal_touch/_nociception	1.35222640
37	MP0005645_abnormal_hypothalamus_physiol	1.34350292
38	MP0002735_abnormal_chemical_nociception	1.33414615
39	MP0005377_hearing/vestibular/ear_phenot	1.33047536
40	MP0003878_abnormal_ear_physiology	1.33047536
41	MP0000470_abnormal_stomach_morphology	1.32556504
42	MP0001929_abnormal_gametogenesis	1.31794872
43	MP0005646_abnormal_pituitary_gland	1.29931815
44	MP0001663_abnormal_digestive_system	1.22730722
45	MP0001664_abnormal_digestion	1.21569008
46	MP0001800_abnormal_humoral_immune	1.20668403
47	MP0008877_abnormal_DNA_methylation	1.20538888
48	MP0001501_abnormal_sleep_pattern	1.20172129
49	MP0005448_abnormal_energy_balance	1.14785277
50	MP0003718_maternal_effect	1.14014662
51	MP0002928_abnormal_bile_duct	1.13208445
52	MP0004742_abnormal_vestibular_system	1.11746868
53	MP0002006_tumorigenesis	1.09227343
54	MP0005083_abnormal_biliary_tract	1.08023788
55	MP0010386_abnormal_urinary_bladder	1.07413181
56	MP0005167_abnormal_blood-brain_barrier	1.06551521
57	MP0003693_abnormal_embryo_hatching	1.02603385
58	MP0001873_stomach_inflammation	1.01722607
59	MP0002822_catalepsy	0.99821990
60	MP0002396_abnormal_hematopoietic_system	0.99694307
61	MP0001986_abnormal_taste_sensitivity	0.98603036
62	MP0004924_abnormal_behavior	0.97711318
63	MP0005386_behavior/neurological_phenoty	0.97711318
64	MP0002148_abnormal_hypersensitivity_rea	0.97256022
65	MP0009046_muscle_twitch	0.96543922
66	MP0002160_abnormal_reproductive_system	0.94997172
67	MP0002229_neurodegeneration	0.94621204
68	MP0004264_abnormal_extraembryonic_tissu	0.92798060
69	MP0001790_abnormal_immune_system	0.92754241
70	MP0005387_immune_system_phenotype	0.92754241
71	MP0000703_abnormal_thymus_morphology	0.91380994
72	MP0002210_abnormal_sex_determination	0.90796867
73	MP0005397_hematopoietic_system_phenotyp	0.90320094
74	MP0001545_abnormal_hematopoietic_system	0.90320094
75	MP0000383_abnormal_hair_follicle	0.89650801
76	MP0008961_abnormal_basal_metabolism	0.89031815
77	MP0005266_abnormal_metabolism	0.88822531
78	MP0005389_reproductive_system_phenotype	0.88139041
79	MP0002733_abnormal_thermal_nociception	0.87528871
80	MP0001270_distended_abdomen	0.86786065
81	MP0002398_abnormal_bone_marrow	0.86595948
82	MP0002452_abnormal_antigen_presenting	0.84473613
83	MP0003252_abnormal_bile_duct	0.83937776
84	MP0002876_abnormal_thyroid_physiology	0.83519803
85	MP0000372_irregular_coat_pigmentation	0.80978248
86	MP0002420_abnormal_adaptive_immunity	0.80295507
87	MP0002693_abnormal_pancreas_physiology	0.80072569
88	MP0001819_abnormal_immune_cell	0.79745893
89	MP0001905_abnormal_dopamine_level	0.79585495
90	MP0005381_digestive/alimentary_phenotyp	0.79575688
91	MP0002837_dystrophic_cardiac_calcinosis	0.79250082
92	MP0002722_abnormal_immune_system	0.76788871
93	MP0004808_abnormal_hematopoietic_stem	0.76538019
94	MP0005395_other_phenotype	0.75345488
95	MP0000689_abnormal_spleen_morphology	0.75271924
96	MP0001764_abnormal_homeostasis	0.75108345
97	MP0001502_abnormal_circadian_rhythm	0.73908810
98	MP0001963_abnormal_hearing_physiology	0.73807331
99	MP0002723_abnormal_immune_serum	0.73797484
100	MP0000230_abnormal_systemic_arterial	0.73274308

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the fingertips (HP:0001211)	3.41847518
2	Abnormality of the renal cortex (HP:0011035)	3.20809897
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.17934343
4	Impulsivity (HP:0100710)	3.10124878
5	Cerebellar dysplasia (HP:0007033)	2.92799566
6	Tubulointerstitial nephritis (HP:0001970)	2.88814024
7	Panhypogammaglobulinemia (HP:0003139)	2.88610775
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.84130167
9	Hyperventilation (HP:0002883)	2.83968317
10	Chromsome breakage (HP:0040012)	2.81818616
11	Attenuation of retinal blood vessels (HP:0007843)	2.80848810
12	Enlarged epiphyses (HP:0010580)	2.80436187
13	Thyroiditis (HP:0100646)	2.78985902
14	Abnormality of the renal collecting system (HP:0004742)	2.70938052
15	Stomach cancer (HP:0012126)	2.70432887
16	Abnormality of the renal medulla (HP:0100957)	2.67160350
17	Renal cortical cysts (HP:0000803)	2.66877611
18	Congenital sensorineural hearing impairment (HP:0008527)	2.64398769
19	Congenital, generalized hypertrichosis (HP:0004540)	2.62412677
20	Hyperkalemia (HP:0002153)	2.62290945
21	Abnormality of chloride homeostasis (HP:0011422)	2.60793682
22	Duplicated collecting system (HP:0000081)	2.60439397
23	Palpebral edema (HP:0100540)	2.55611490
24	Type II lissencephaly (HP:0007260)	2.55375530
25	Abnormality of B cell number (HP:0010975)	2.55278392
26	Abnormality of the preputium (HP:0100587)	2.49701227
27	Cystic liver disease (HP:0006706)	2.48149590
28	Ectopic kidney (HP:0000086)	2.45327016
29	Adactyly (HP:0009776)	2.45301207
30	Pancreatic cysts (HP:0001737)	2.42918750
31	Severe combined immunodeficiency (HP:0004430)	2.40892842
32	Abnormality of the columella (HP:0009929)	2.40419462
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.37310963
34	Autoimmune thrombocytopenia (HP:0001973)	2.32745277
35	Nephronophthisis (HP:0000090)	2.32309792
36	Hypergonadotropic hypogonadism (HP:0000815)	2.31641000
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.31577310
38	Pancreatic fibrosis (HP:0100732)	2.30598808
39	Spinal muscular atrophy (HP:0007269)	2.29282980
40	Clubbing of toes (HP:0100760)	2.26089095
41	Stomatitis (HP:0010280)	2.25518829
42	Autoimmune hemolytic anemia (HP:0001890)	2.23418456
43	Gaze-evoked nystagmus (HP:0000640)	2.18980802
44	Abnormality of the ileum (HP:0001549)	2.18662093
45	Abnormality of chromosome stability (HP:0003220)	2.17288227
46	Abnormal biliary tract physiology (HP:0012439)	2.16931242
47	Bile duct proliferation (HP:0001408)	2.16931242
48	Abnormality of midbrain morphology (HP:0002418)	2.15446805
49	Molar tooth sign on MRI (HP:0002419)	2.15446805
50	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.14283106
51	Glioma (HP:0009733)	2.13806970
52	Abnormality of vitamin B metabolism (HP:0004340)	2.10830976
53	Severe visual impairment (HP:0001141)	2.08640420
54	Pendular nystagmus (HP:0012043)	2.06584818
55	Tubulointerstitial abnormality (HP:0001969)	2.04688835
56	Keratoconus (HP:0000563)	2.02494194
57	Increased corneal curvature (HP:0100692)	2.02494194
58	IgM deficiency (HP:0002850)	2.01741883
59	Abnormality of the nasal septum (HP:0000419)	2.01433255
60	Tongue fasciculations (HP:0001308)	2.00808952
61	Abnormality of the carotid arteries (HP:0005344)	1.98686657
62	Meckel diverticulum (HP:0002245)	1.97981132
63	Tubular atrophy (HP:0000092)	1.96863550
64	Congenital hepatic fibrosis (HP:0002612)	1.96336727
65	Broad-based gait (HP:0002136)	1.95648606
66	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.95459684
67	Methylmalonic acidemia (HP:0002912)	1.95296714
68	Abnormality of dental color (HP:0011073)	1.93854781
69	Delayed CNS myelination (HP:0002188)	1.93680103
70	Tented upper lip vermilion (HP:0010804)	1.92598857
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91530501
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.91530501
73	Abnormal protein glycosylation (HP:0012346)	1.91530501
74	Abnormal glycosylation (HP:0012345)	1.91530501
75	Prominent nose (HP:0000448)	1.91126382
76	Hypoplasia of the pons (HP:0012110)	1.90747696
77	Abnormal hair whorl (HP:0010721)	1.90549181
78	Fair hair (HP:0002286)	1.90151046
79	Bulbous nose (HP:0000414)	1.90024532
80	Neurodegeneration (HP:0002180)	1.89977570
81	Abnormality of dentin (HP:0010299)	1.89483665
82	Volvulus (HP:0002580)	1.88820608
83	Neoplasm of the adrenal cortex (HP:0100641)	1.88432405
84	Abnormality of lateral ventricle (HP:0030047)	1.86718891
85	Absent speech (HP:0001344)	1.86543933
86	True hermaphroditism (HP:0010459)	1.85854153
87	Hypophosphatemic rickets (HP:0004912)	1.85668960
88	Congenital stationary night blindness (HP:0007642)	1.84878847
89	Eosinophilia (HP:0001880)	1.84026820
90	Ependymoma (HP:0002888)	1.83699780
91	Tubulointerstitial fibrosis (HP:0005576)	1.83408197
92	Thyroid-stimulating hormone excess (HP:0002925)	1.82887392
93	Protruding tongue (HP:0010808)	1.82687403
94	Pili torti (HP:0003777)	1.82538836
95	Sloping forehead (HP:0000340)	1.81121495
96	Hypoproteinemia (HP:0003075)	1.80775683
97	Clumsiness (HP:0002312)	1.79972075
98	Methylmalonic aciduria (HP:0012120)	1.77348078
99	Abnormality of small intestinal villus morphology (HP:0011472)	1.77172120
100	Villous atrophy (HP:0011473)	1.77172120

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.03358923
2	WNK4	4.85129572
3	MST1R	3.88219523
4	BMPR1B	3.54961959
5	NME1	2.95855969
6	INSRR	2.72727113
7	MET	2.48067352
8	ZAK	2.37423088
9	STK39	2.03880431
10	CDK12	1.91833209
11	PINK1	1.79461563
12	ACVR1B	1.73983005
13	MAP4K2	1.73562188
14	PLK4	1.69868971
15	WNK1	1.68133810
16	NUAK1	1.55886257
17	FGFR2	1.45730894
18	CAMK1D	1.36038401
19	OXSR1	1.30852889
20	GRK1	1.27014748
21	STK38	1.26315597
22	MAPK13	1.25097109
23	ADRBK2	1.24348714
24	AKT3	1.22296000
25	MAP2K6	1.22243092
26	PIK3CA	1.19914975
27	BLK	1.18279568
28	TEC	1.11165250
29	TAOK3	1.10553347
30	TNIK	1.06745159
31	MAP4K1	1.05796954
32	TXK	1.05016422
33	KIT	1.02955745
34	STK38L	0.99217075
35	CAMK1G	0.96760038
36	CAMKK2	0.94925342
37	NEK2	0.93057516
38	CASK	0.92815646
39	ATR	0.90080937
40	WNK3	0.89292754
41	TGFBR1	0.83928054
42	TNK2	0.80655397
43	MUSK	0.80548201
44	EPHA3	0.78565295
45	PDK2	0.77413305
46	CSNK1A1L	0.77128681
47	SYK	0.75707272
48	MKNK2	0.73521345
49	CSNK1G3	0.72058492
50	CDK8	0.69498503
51	CDK3	0.69343117
52	MST4	0.67807701
53	CSNK1G1	0.67606373
54	NLK	0.67438861
55	ERBB2	0.66641746
56	SIK2	0.66251074
57	PTK2B	0.66237491
58	PHKG1	0.64708543
59	PHKG2	0.64708543
60	CSF1R	0.64438971
61	DAPK2	0.64088010
62	PLK2	0.62823043
63	MKNK1	0.61415225
64	ITK	0.60589757
65	BRSK2	0.59920807
66	BRD4	0.58490424
67	CHUK	0.58431095
68	TLK1	0.58349082
69	OBSCN	0.56398946
70	MAPK11	0.55533510
71	PRKAA2	0.54353671
72	GRK7	0.52258290
73	PDK1	0.50298300
74	IKBKB	0.50217422
75	MAPK15	0.49471669
76	PAK3	0.48215532
77	MARK3	0.46036050
78	ATM	0.45768891
79	LYN	0.45310810
80	BTK	0.45073994
81	LCK	0.42609283
82	EIF2AK3	0.39392308
83	HIPK2	0.39154365
84	PKN1	0.38693043
85	RPS6KA5	0.38637763
86	FGFR3	0.38527129
87	CHEK1	0.37703808
88	PRKCQ	0.37466163
89	ADRBK1	0.34364873
90	FER	0.33425760
91	MAPK1	0.32825053
92	CSNK1A1	0.32582068
93	CSNK1G2	0.31596402
94	PRKCE	0.31098780
95	PRKAA1	0.30468268
96	PBK	0.29886281
97	HCK	0.29841042
98	FES	0.29667066
99	MAP3K4	0.29223510
100	TRPM7	0.27759645

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	6.27409124
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.92177174
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.71951171
4	* Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.60099750
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.40002635
6	Asthma_Homo sapiens_hsa05310	2.36919969
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30407309
8	Olfactory transduction_Homo sapiens_hsa04740	2.26500175
9	RNA polymerase_Homo sapiens_hsa03020	2.21562680
10	Homologous recombination_Homo sapiens_hsa03440	2.17571877
11	Butanoate metabolism_Homo sapiens_hsa00650	2.16516112
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.09945143
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.05333335
14	* Oocyte meiosis_Homo sapiens_hsa04114	2.01205463
15	Phototransduction_Homo sapiens_hsa04744	2.00712829
16	Lysine degradation_Homo sapiens_hsa00310	1.81676597
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78117863
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68819389
19	Allograft rejection_Homo sapiens_hsa05330	1.65601177
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.58992701
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56697895
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53888962
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49046072
24	ABC transporters_Homo sapiens_hsa02010	1.45053397
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.36456470
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31707487
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30587386
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.30344112
29	Salivary secretion_Homo sapiens_hsa04970	1.29423161
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27149503
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21479782
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.18226410
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.15628889
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.14041815
35	Taste transduction_Homo sapiens_hsa04742	1.12113844
36	Basal transcription factors_Homo sapiens_hsa03022	1.10930288
37	Peroxisome_Homo sapiens_hsa04146	1.05788212
38	Propanoate metabolism_Homo sapiens_hsa00640	1.04145007
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99710538
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99489035
41	Base excision repair_Homo sapiens_hsa03410	0.97127772
42	RNA degradation_Homo sapiens_hsa03018	0.95681812
43	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.94317532
44	Non-homologous end-joining_Homo sapiens_hsa03450	0.93718133
45	Purine metabolism_Homo sapiens_hsa00230	0.90394029
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81673568
47	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78979743
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.78241415
49	Protein digestion and absorption_Homo sapiens_hsa04974	0.76911963
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76494832
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76226720
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.76056753
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72221133
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70245824
55	RNA transport_Homo sapiens_hsa03013	0.69730964
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69723330
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.69425829
58	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.69406915
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.68107158
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66993792
61	Gastric acid secretion_Homo sapiens_hsa04971	0.66696941
62	Other glycan degradation_Homo sapiens_hsa00511	0.65336652
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64783464
64	Insulin secretion_Homo sapiens_hsa04911	0.64036522
65	One carbon pool by folate_Homo sapiens_hsa00670	0.62625421
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61486629
67	Renin secretion_Homo sapiens_hsa04924	0.57271318
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57200276
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52948123
70	Pancreatic secretion_Homo sapiens_hsa04972	0.52859094
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.52809306
72	DNA replication_Homo sapiens_hsa03030	0.50399654
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48906490
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48516241
75	Platelet activation_Homo sapiens_hsa04611	0.48425529
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46630890
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45956117
78	African trypanosomiasis_Homo sapiens_hsa05143	0.45899273
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45793057
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45641874
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44984416
82	Sulfur relay system_Homo sapiens_hsa04122	0.43781624
83	Herpes simplex infection_Homo sapiens_hsa05168	0.42354513
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42263654
85	Proteasome_Homo sapiens_hsa03050	0.40295630
86	Long-term depression_Homo sapiens_hsa04730	0.37862746
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36974196
88	Metabolic pathways_Homo sapiens_hsa01100	0.33610344
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.32130134
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31010972
91	Retinol metabolism_Homo sapiens_hsa00830	0.29740086
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29477486
93	Protein export_Homo sapiens_hsa03060	0.29313145
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25496134
95	Fatty acid degradation_Homo sapiens_hsa00071	0.25147886
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.22663745
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.22294649
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21912665
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.21522068
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.21311244

SPDYE2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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