ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of telomere maintenance (GO:0032205)	4.25163555
2	mannosylation (GO:0097502)	4.21354641
3	DNA deamination (GO:0045006)	3.86007544
4	cellular response to exogenous dsRNA (GO:0071360)	3.79588787
5	piRNA metabolic process (GO:0034587)	3.76386796
6	preassembly of GPI anchor in ER membrane (GO:0016254)	3.75048815
7	mismatch repair (GO:0006298)	3.69370022
8	protein polyglutamylation (GO:0018095)	3.66574961
9	base-excision repair, AP site formation (GO:0006285)	3.52351781
10	regulation of telomere maintenance (GO:0032204)	3.47461560
11	centriole replication (GO:0007099)	3.33850424
12	regulation of cilium movement (GO:0003352)	3.33645868
13	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.32753014
14	seminiferous tubule development (GO:0072520)	3.24106127
15	behavioral response to nicotine (GO:0035095)	3.22465379
16	L-fucose catabolic process (GO:0042355)	3.22132175
17	fucose catabolic process (GO:0019317)	3.22132175
18	L-fucose metabolic process (GO:0042354)	3.22132175
19	GPI anchor metabolic process (GO:0006505)	3.18628614
20	rRNA catabolic process (GO:0016075)	3.15761348
21	DNA double-strand break processing (GO:0000729)	3.14913649
22	ubiquinone biosynthetic process (GO:0006744)	3.08089847
23	DNA methylation involved in gamete generation (GO:0043046)	3.07568407
24	axoneme assembly (GO:0035082)	3.06285994
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05785146
26	pyrimidine nucleotide catabolic process (GO:0006244)	3.04637592
27	NADH dehydrogenase complex assembly (GO:0010257)	3.03476138
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.03476138
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.03476138
30	recombinational repair (GO:0000725)	2.99916850
31	indolalkylamine metabolic process (GO:0006586)	2.98944787
32	replication fork processing (GO:0031297)	2.98654537
33	autophagic vacuole fusion (GO:0000046)	2.98090967
34	GPI anchor biosynthetic process (GO:0006506)	2.98038032
35	double-strand break repair via homologous recombination (GO:0000724)	2.97991523
36	histone H3-K9 methylation (GO:0051567)	2.97817415
37	protein complex biogenesis (GO:0070271)	2.93191748
38	indole-containing compound catabolic process (GO:0042436)	2.86053500
39	indolalkylamine catabolic process (GO:0046218)	2.86053500
40	tryptophan catabolic process (GO:0006569)	2.86053500
41	ubiquinone metabolic process (GO:0006743)	2.84207396
42	photoreceptor cell maintenance (GO:0045494)	2.83953741
43	cellular ketone body metabolic process (GO:0046950)	2.83185012
44	C-terminal protein lipidation (GO:0006501)	2.82867639
45	detection of light stimulus involved in sensory perception (GO:0050962)	2.82826070
46	detection of light stimulus involved in visual perception (GO:0050908)	2.82826070
47	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.81171495
48	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.80999782
49	tryptophan metabolic process (GO:0006568)	2.80836272
50	peptidyl-histidine modification (GO:0018202)	2.79634078
51	branched-chain amino acid catabolic process (GO:0009083)	2.78352699
52	DNA modification (GO:0006304)	2.77661285
53	respiratory chain complex IV assembly (GO:0008535)	2.77580678
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77414853
55	deoxyribonucleotide catabolic process (GO:0009264)	2.76632784
56	nonmotile primary cilium assembly (GO:0035058)	2.73900329
57	cytochrome complex assembly (GO:0017004)	2.72336278
58	reciprocal meiotic recombination (GO:0007131)	2.71290913
59	reciprocal DNA recombination (GO:0035825)	2.71290913
60	cell wall macromolecule metabolic process (GO:0044036)	2.71275921
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70615308
62	metallo-sulfur cluster assembly (GO:0031163)	2.70063818
63	iron-sulfur cluster assembly (GO:0016226)	2.70063818
64	anterograde synaptic vesicle transport (GO:0048490)	2.69698173
65	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.69141571
66	neural tube formation (GO:0001841)	2.68917311
67	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68842265
68	tRNA modification (GO:0006400)	2.68458586
69	kynurenine metabolic process (GO:0070189)	2.68267394
70	positive regulation of mitochondrial fission (GO:0090141)	2.67153875
71	inositol phosphate catabolic process (GO:0071545)	2.66945788
72	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.65644598
73	amino acid salvage (GO:0043102)	2.65489968
74	L-methionine salvage (GO:0071267)	2.65489968
75	L-methionine biosynthetic process (GO:0071265)	2.65489968
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65434231
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.62366583
78	DNA demethylation (GO:0080111)	2.61553533
79	DNA integration (GO:0015074)	2.60610947
80	positive regulation of developmental pigmentation (GO:0048087)	2.60446910
81	branched-chain amino acid metabolic process (GO:0009081)	2.59255685
82	intraciliary transport (GO:0042073)	2.58650890
83	ketone body metabolic process (GO:1902224)	2.58079524
84	epithelial cilium movement (GO:0003351)	2.57503631
85	pyrimidine dimer repair (GO:0006290)	2.57474359
86	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.57205570
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.57205570
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56943501
89	cilium or flagellum-dependent cell motility (GO:0001539)	2.55499863
90	platelet dense granule organization (GO:0060155)	2.54652052
91	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.52357859
92	inositol phosphate dephosphorylation (GO:0046855)	2.52357859
93	positive regulation of granulocyte differentiation (GO:0030854)	2.50883527
94	actin nucleation (GO:0045010)	2.50812775
95	DNA methylation or demethylation (GO:0044728)	2.50536857
96	deoxyribose phosphate catabolic process (GO:0046386)	2.49948398
97	organelle membrane fusion (GO:0090174)	2.49419898
98	arginine catabolic process (GO:0006527)	2.48031917
99	cilium organization (GO:0044782)	2.47851946
100	maturation of 5.8S rRNA (GO:0000460)	2.47494302

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74676008
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00988233
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94152386
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.90045920
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72771954
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55564174
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54044646
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47296529
9	VDR_22108803_ChIP-Seq_LS180_Human	2.45198931
10	CIITA_25753668_ChIP-Seq_RAJI_Human	2.34366308
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.33192848
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.26077696
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20148040
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.15006196
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14580259
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.13706535
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05508316
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.03214455
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02603796
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.01697426
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95817134
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85366884
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.80838748
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77602701
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.73151455
26	SCL_19346495_ChIP-Seq_HPC-7_Human	1.73085727
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.70553764
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.67963448
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67698107
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64494215
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64391997
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59187017
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.58104013
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.57682980
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.55078898
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54673138
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.51288719
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48157155
39	EWS_26573619_Chip-Seq_HEK293_Human	1.45628186
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44123096
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.43179301
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42897257
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36102163
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35546852
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.33786620
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33786620
47	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31946014
48	ERA_21632823_ChIP-Seq_H3396_Human	1.30500205
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27665786
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25836027
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24873277
52	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23803057
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22926408
54	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22778061
55	GATA3_26560356_Chip-Seq_TH2_Human	1.21755105
56	AR_20517297_ChIP-Seq_VCAP_Human	1.20222643
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16975220
58	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.15742649
59	NCOR_22424771_ChIP-Seq_293T_Human	1.15523607
60	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.14822974
61	FUS_26573619_Chip-Seq_HEK293_Human	1.14106794
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13320058
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12294677
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10184666
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.09893175
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08620389
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07164903
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07164903
69	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07060441
70	GATA3_27048872_Chip-Seq_THYMUS_Human	1.05488994
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04701240
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04701240
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02925168
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02398383
75	KDM5A_27292631_Chip-Seq_BREAST_Human	1.02380295
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00693745
77	TAF15_26573619_Chip-Seq_HEK293_Human	1.00295928
78	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.99990201
79	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99553883
80	* BCL6_27268052_Chip-Seq_Bcells_Human	0.99097466
81	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98460332
82	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97647139
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97186785
84	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96995900
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96972813
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96416294
87	TCF4_23295773_ChIP-Seq_U87_Human	0.96318408
88	P300_19829295_ChIP-Seq_ESCs_Human	0.95819493
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95589785
90	STAT3_23295773_ChIP-Seq_U87_Human	0.94829729
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94568302
92	* RAC3_21632823_ChIP-Seq_H3396_Human	0.94259908
93	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.93486313
94	E2F1_20622854_ChIP-Seq_HELA_Human	0.93353045
95	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.93341584
96	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93151026
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92928274
98	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91221121
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90366774
100	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.90208609

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	3.04649661
2	MP0008877_abnormal_DNA_methylation	2.76309911
3	MP0005645_abnormal_hypothalamus_physiol	2.61328047
4	MP0003787_abnormal_imprinting	2.59550715
5	MP0005075_abnormal_melanosome_morpholog	2.38807549
6	MP0008058_abnormal_DNA_repair	2.27412486
7	MP0002102_abnormal_ear_morphology	2.24005868
8	MP0006292_abnormal_olfactory_placode	2.17678307
9	MP0003880_abnormal_central_pattern	2.14256136
10	MP0001986_abnormal_taste_sensitivity	2.11583599
11	MP0006072_abnormal_retinal_apoptosis	2.07634519
12	MP0000372_irregular_coat_pigmentation	2.04887338
13	MP0005551_abnormal_eye_electrophysiolog	2.04368536
14	MP0005646_abnormal_pituitary_gland	1.99263625
15	MP0000569_abnormal_digit_pigmentation	1.97285204
16	MP0004043_abnormal_pH_regulation	1.96664645
17	MP0001968_abnormal_touch/_nociception	1.91542234
18	MP0004145_abnormal_muscle_electrophysio	1.88885140
19	MP0003646_muscle_fatigue	1.75862970
20	MP0005253_abnormal_eye_physiology	1.69264637
21	MP0002822_catalepsy	1.68003591
22	MP0000015_abnormal_ear_pigmentation	1.67131275
23	MP0006276_abnormal_autonomic_nervous	1.67031331
24	MP0009278_abnormal_bone_marrow	1.60924439
25	MP0008872_abnormal_physiological_respon	1.59083682
26	MP0002095_abnormal_skin_pigmentation	1.55485344
27	MP0005394_taste/olfaction_phenotype	1.44199172
28	MP0005499_abnormal_olfactory_system	1.44199172
29	MP0002736_abnormal_nociception_after	1.43691903
30	MP0005174_abnormal_tail_pigmentation	1.42630382
31	MP0004142_abnormal_muscle_tone	1.42507683
32	MP0008789_abnormal_olfactory_epithelium	1.41584655
33	MP0010094_abnormal_chromosome_stability	1.34016634
34	MP0002735_abnormal_chemical_nociception	1.32810933
35	MP0001545_abnormal_hematopoietic_system	1.32314005
36	MP0005397_hematopoietic_system_phenotyp	1.32314005
37	MP0003121_genomic_imprinting	1.32141181
38	MP0008995_early_reproductive_senescence	1.31850436
39	MP0001984_abnormal_olfaction	1.27940964
40	MP0009046_muscle_twitch	1.27891754
41	MP0001800_abnormal_humoral_immune	1.24831750
42	MP0001835_abnormal_antigen_presentation	1.23531692
43	MP0002837_dystrophic_cardiac_calcinosis	1.22802159
44	MP0008875_abnormal_xenobiotic_pharmacok	1.22392273
45	MP0003718_maternal_effect	1.22174833
46	MP0005671_abnormal_response_to	1.21553248
47	MP0002138_abnormal_hepatobiliary_system	1.20604636
48	MP0001905_abnormal_dopamine_level	1.14767849
49	MP0000631_abnormal_neuroendocrine_gland	1.14436860
50	MP0004147_increased_porphyrin_level	1.13563748
51	MP0002733_abnormal_thermal_nociception	1.13314801
52	MP0002557_abnormal_social/conspecific_i	1.11306348
53	MP0001486_abnormal_startle_reflex	1.10731864
54	MP0003122_maternal_imprinting	1.10416717
55	MP0009745_abnormal_behavioral_response	1.08355525
56	MP0002938_white_spotting	1.07729388
57	MP0000465_gastrointestinal_hemorrhage	1.07631992
58	MP0005423_abnormal_somatic_nervous	1.06548664
59	MP0003786_premature_aging	1.04821943
60	MP0001764_abnormal_homeostasis	1.03304204
61	MP0001929_abnormal_gametogenesis	1.01451764
62	MP0002272_abnormal_nervous_system	1.00287606
63	MP0003698_abnormal_male_reproductive	0.98597980
64	MP0006036_abnormal_mitochondrial_physio	0.97844546
65	MP0001970_abnormal_pain_threshold	0.96743736
66	MP0001501_abnormal_sleep_pattern	0.95755637
67	MP0000689_abnormal_spleen_morphology	0.95047682
68	MP0002572_abnormal_emotion/affect_behav	0.94618209
69	MP0000427_abnormal_hair_cycle	0.91741594
70	MP0004133_heterotaxia	0.91400611
71	MP0002751_abnormal_autonomic_nervous	0.90887292
72	MP0002398_abnormal_bone_marrow	0.87473672
73	MP0002234_abnormal_pharynx_morphology	0.87335494
74	MP0001529_abnormal_vocalization	0.87179741
75	MP0002723_abnormal_immune_serum	0.86681109
76	MP0002420_abnormal_adaptive_immunity	0.85253596
77	MP0002210_abnormal_sex_determination	0.85090325
78	MP0002752_abnormal_somatic_nervous	0.84553512
79	MP0006035_abnormal_mitochondrial_morpho	0.84551698
80	MP0003136_yellow_coat_color	0.84449941
81	MP0001819_abnormal_immune_cell	0.83450922
82	MP0002067_abnormal_sensory_capabilities	0.83057808
83	MP0004924_abnormal_behavior	0.82116003
84	MP0005386_behavior/neurological_phenoty	0.82116003
85	MP0002928_abnormal_bile_duct	0.82099918
86	MP0003195_calcinosis	0.81552825
87	MP0005195_abnormal_posterior_eye	0.80927107
88	MP0000778_abnormal_nervous_system	0.80421779
89	MP0002452_abnormal_antigen_presenting	0.80325793
90	MP0005410_abnormal_fertilization	0.80095474
91	MP0003045_fibrosis	0.78118896
92	MP0004381_abnormal_hair_follicle	0.77911117
93	MP0000653_abnormal_sex_gland	0.77795074
94	MP0000716_abnormal_immune_system	0.77750373
95	MP0005171_absent_coat_pigmentation	0.77582395
96	MP0001324_abnormal_eye_pigmentation	0.76787413
97	MP0001145_abnormal_male_reproductive	0.76150057
98	MP0002396_abnormal_hematopoietic_system	0.75854165
99	MP0003635_abnormal_synaptic_transmissio	0.75818832
100	MP0003763_abnormal_thymus_physiology	0.75664130

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.90630904
2	Congenital stationary night blindness (HP:0007642)	3.66121169
3	Nephronophthisis (HP:0000090)	3.63262145
4	Pancreatic fibrosis (HP:0100732)	3.56495067
5	Panhypogammaglobulinemia (HP:0003139)	3.36851211
6	True hermaphroditism (HP:0010459)	3.32509887
7	Molar tooth sign on MRI (HP:0002419)	3.29673555
8	Abnormality of midbrain morphology (HP:0002418)	3.29673555
9	Medial flaring of the eyebrow (HP:0010747)	3.28243927
10	Abnormality of the renal medulla (HP:0100957)	3.24562024
11	Abnormality of the renal cortex (HP:0011035)	3.24290998
12	Tubulointerstitial nephritis (HP:0001970)	2.78823176
13	Attenuation of retinal blood vessels (HP:0007843)	2.71605504
14	Cystic liver disease (HP:0006706)	2.70106686
15	Hepatocellular necrosis (HP:0001404)	2.69626328
16	Chronic hepatic failure (HP:0100626)	2.68413651
17	Gait imbalance (HP:0002141)	2.65164465
18	Genetic anticipation (HP:0003743)	2.63967785
19	3-Methylglutaconic aciduria (HP:0003535)	2.62441578
20	Renal cortical cysts (HP:0000803)	2.62008723
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.55979139
22	Congenital primary aphakia (HP:0007707)	2.54565028
23	Nephrogenic diabetes insipidus (HP:0009806)	2.49045129
24	Mitochondrial inheritance (HP:0001427)	2.48628186
25	Abnormality of DNA repair (HP:0003254)	2.47268021
26	Hepatic necrosis (HP:0002605)	2.46017166
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.44312063
28	Type I transferrin isoform profile (HP:0003642)	2.44276964
29	Type II lissencephaly (HP:0007260)	2.42459402
30	Pachygyria (HP:0001302)	2.35886562
31	Decreased central vision (HP:0007663)	2.32960227
32	Bile duct proliferation (HP:0001408)	2.32387695
33	Abnormal biliary tract physiology (HP:0012439)	2.32387695
34	Congenital hepatic fibrosis (HP:0002612)	2.28180869
35	Increased CSF lactate (HP:0002490)	2.26831303
36	Lissencephaly (HP:0001339)	2.23047849
37	Progressive cerebellar ataxia (HP:0002073)	2.21544424
38	Cerebellar dysplasia (HP:0007033)	2.21165954
39	Abnormality of B cell number (HP:0010975)	2.20869793
40	Stomach cancer (HP:0012126)	2.20571459
41	Elevated erythrocyte sedimentation rate (HP:0003565)	2.20180984
42	Acute necrotizing encephalopathy (HP:0006965)	2.18679128
43	Hyperventilation (HP:0002883)	2.18388994
44	Inability to walk (HP:0002540)	2.18111707
45	Severe combined immunodeficiency (HP:0004430)	2.17853153
46	Abnormal protein glycosylation (HP:0012346)	2.17590238
47	Abnormal glycosylation (HP:0012345)	2.17590238
48	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17590238
49	Abnormal protein N-linked glycosylation (HP:0012347)	2.17590238
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16608820
51	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14853188
52	Retinal dysplasia (HP:0007973)	2.14830446
53	Tubular atrophy (HP:0000092)	2.14542152
54	Absent thumb (HP:0009777)	2.13923997
55	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11913776
56	Colon cancer (HP:0003003)	2.09274469
57	Abolished electroretinogram (ERG) (HP:0000550)	2.05972703
58	Progressive microcephaly (HP:0000253)	2.04103639
59	Agammaglobulinemia (HP:0004432)	2.02994820
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02271569
61	Dicarboxylic aciduria (HP:0003215)	1.97934679
62	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.97934679
63	Tented upper lip vermilion (HP:0010804)	1.97377938
64	Poor coordination (HP:0002370)	1.96713893
65	Progressive inability to walk (HP:0002505)	1.96289880
66	Acute encephalopathy (HP:0006846)	1.95600929
67	Abnormal number of erythroid precursors (HP:0012131)	1.95240399
68	Severe visual impairment (HP:0001141)	1.94490933
69	Lipid accumulation in hepatocytes (HP:0006561)	1.94175063
70	Postaxial foot polydactyly (HP:0001830)	1.93841106
71	Absent speech (HP:0001344)	1.91903117
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91582956
73	Methylmalonic acidemia (HP:0002912)	1.90049939
74	Ketosis (HP:0001946)	1.88574266
75	Tubulointerstitial abnormality (HP:0001969)	1.88568054
76	Sclerocornea (HP:0000647)	1.87074434
77	IgG deficiency (HP:0004315)	1.87073427
78	Anencephaly (HP:0002323)	1.86883267
79	Patellar aplasia (HP:0006443)	1.84138134
80	Focal motor seizures (HP:0011153)	1.83478572
81	Retinitis pigmentosa (HP:0000510)	1.82920067
82	B lymphocytopenia (HP:0010976)	1.82547108
83	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.80815713
84	Neutropenia (HP:0001875)	1.80556768
85	Chromsome breakage (HP:0040012)	1.79626352
86	Polydipsia (HP:0001959)	1.79111947
87	Abnormal drinking behavior (HP:0030082)	1.79111947
88	Broad-based gait (HP:0002136)	1.78107300
89	Methylmalonic aciduria (HP:0012120)	1.77822174
90	Increased hepatocellular lipid droplets (HP:0006565)	1.77580432
91	Increased serum lactate (HP:0002151)	1.77428014
92	Progressive macrocephaly (HP:0004481)	1.76885047
93	Eosinophilia (HP:0001880)	1.75106535
94	Prominent nasal bridge (HP:0000426)	1.74119475
95	Sloping forehead (HP:0000340)	1.73501345
96	Aganglionic megacolon (HP:0002251)	1.72753897
97	Clubbing of toes (HP:0100760)	1.71509503
98	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71025814
99	Pendular nystagmus (HP:0012043)	1.71024143
100	Granulocytopenia (HP:0001913)	1.70416204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.78768368
2	FRK	4.04837497
3	MAP4K2	3.72686458
4	NUAK1	3.12209249
5	BCKDK	2.94155825
6	VRK2	2.16908844
7	MAP3K4	2.16640383
8	BMPR1B	2.00299313
9	WNK3	1.98927745
10	STK16	1.94186921
11	MAPK13	1.93301064
12	ZAK	1.90677022
13	WNK4	1.90624722
14	MAP4K1	1.79093215
15	MAP2K7	1.77532988
16	KIT	1.72891734
17	TRIM28	1.63702526
18	TNK2	1.59272259
19	ADRBK2	1.51106413
20	INSRR	1.46854236
21	MAPKAPK3	1.45524050
22	CSNK1A1L	1.44100747
23	TESK2	1.36182129
24	SYK	1.32039926
25	GRK1	1.31722585
26	CSNK1G3	1.29372281
27	NME1	1.28218288
28	TXK	1.27215944
29	NEK2	1.25188928
30	ATR	1.24771550
31	MUSK	1.23648913
32	MARK1	1.16778686
33	BTK	1.14400543
34	TEC	1.12879648
35	CSNK1G2	1.11907098
36	PLK4	1.03743795
37	DYRK2	1.02223941
38	FLT3	1.00592553
39	KDR	0.95310277
40	IKBKB	0.93712865
41	VRK1	0.93497488
42	ITK	0.93460317
43	CSNK1G1	0.89818822
44	TLK1	0.89481639
45	DAPK1	0.87558375
46	CCNB1	0.84913328
47	LATS1	0.83838928
48	PIK3CA	0.81777369
49	CDK19	0.76049327
50	PINK1	0.74897045
51	PTK2B	0.74646865
52	DAPK2	0.72910723
53	GRK6	0.72206689
54	SIK2	0.72158969
55	LCK	0.70268322
56	CDK8	0.70167238
57	MAPKAPK5	0.68797267
58	MAPK15	0.67583551
59	TNIK	0.65501085
60	CDK3	0.63600770
61	ADRBK1	0.63546133
62	PRKCQ	0.62472219
63	OXSR1	0.61113445
64	MAP3K6	0.61003448
65	MAP2K2	0.59916263
66	MAPK11	0.55748043
67	LYN	0.55571969
68	STK39	0.54570770
69	BCR	0.53488854
70	IKBKE	0.51100350
71	MARK3	0.49011020
72	FES	0.48871765
73	PRKCG	0.48823411
74	CDC7	0.48636489
75	OBSCN	0.46035356
76	MAP2K6	0.45381541
77	CAMK1	0.44901938
78	SRPK1	0.43851490
79	MAP2K4	0.43146808
80	MAPK3	0.42154967
81	EPHA3	0.41322424
82	CSF1R	0.40665390
83	PHKG2	0.40579262
84	PHKG1	0.40579262
85	RPS6KA5	0.40056684
86	CSNK1A1	0.39748439
87	CHEK2	0.39650256
88	ATM	0.38685371
89	PRKACA	0.38365040
90	SCYL2	0.38254294
91	CSNK1D	0.38118899
92	PRKAA1	0.37371547
93	PAK3	0.37250591
94	TBK1	0.35877351
95	PLK1	0.34022539
96	NTRK2	0.33391150
97	CASK	0.33219605
98	ABL1	0.32018811
99	CDK9	0.31598196
100	CHUK	0.30082703

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.61677204
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.83366839
3	Phototransduction_Homo sapiens_hsa04744	2.78392546
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.61848606
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.59971651
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.55963183
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.50089158
8	RNA polymerase_Homo sapiens_hsa03020	2.49317622
9	Asthma_Homo sapiens_hsa05310	2.44740148
10	Homologous recombination_Homo sapiens_hsa03440	2.37519516
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26118499
12	Butanoate metabolism_Homo sapiens_hsa00650	2.21372251
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.14467612
14	Base excision repair_Homo sapiens_hsa03410	2.05015287
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02265047
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84500816
17	Allograft rejection_Homo sapiens_hsa05330	1.82969793
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.82609177
19	Peroxisome_Homo sapiens_hsa04146	1.81420307
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80001778
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.77566709
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.71888471
23	RNA degradation_Homo sapiens_hsa03018	1.67463423
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.63169724
25	Regulation of autophagy_Homo sapiens_hsa04140	1.60043097
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.59418285
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.53210514
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52974189
29	Parkinsons disease_Homo sapiens_hsa05012	1.52189571
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31576091
31	Propanoate metabolism_Homo sapiens_hsa00640	1.30433705
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29370744
33	Nicotine addiction_Homo sapiens_hsa05033	1.15800127
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15166243
35	Basal transcription factors_Homo sapiens_hsa03022	1.12236406
36	Olfactory transduction_Homo sapiens_hsa04740	1.09665631
37	Purine metabolism_Homo sapiens_hsa00230	1.07255969
38	Huntingtons disease_Homo sapiens_hsa05016	1.07104972
39	Proteasome_Homo sapiens_hsa03050	1.05391739
40	Taste transduction_Homo sapiens_hsa04742	1.01604549
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.96222806
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95409898
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.94632973
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92754896
45	One carbon pool by folate_Homo sapiens_hsa00670	0.91920983
46	Lysine degradation_Homo sapiens_hsa00310	0.89958623
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87076268
48	Mismatch repair_Homo sapiens_hsa03430	0.85508714
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.83520176
50	RNA transport_Homo sapiens_hsa03013	0.81589904
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81443665
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81318162
53	Ribosome_Homo sapiens_hsa03010	0.77182842
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.77016891
55	Protein export_Homo sapiens_hsa03060	0.74382614
56	Morphine addiction_Homo sapiens_hsa05032	0.74204696
57	Alzheimers disease_Homo sapiens_hsa05010	0.72270425
58	Sulfur relay system_Homo sapiens_hsa04122	0.72100971
59	DNA replication_Homo sapiens_hsa03030	0.66955915
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65201908
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64564131
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64165181
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63103021
64	ABC transporters_Homo sapiens_hsa02010	0.62170918
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61870675
66	Viral myocarditis_Homo sapiens_hsa05416	0.61513132
67	Metabolic pathways_Homo sapiens_hsa01100	0.60156634
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59634248
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59563452
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59117349
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.58484048
72	Spliceosome_Homo sapiens_hsa03040	0.56863304
73	GABAergic synapse_Homo sapiens_hsa04727	0.55203559
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54947178
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.53439020
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53321104
77	Salivary secretion_Homo sapiens_hsa04970	0.53110572
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52900955
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52288182
80	Herpes simplex infection_Homo sapiens_hsa05168	0.50430437
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48076476
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46672237
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46667472
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.44320703
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43617171
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43539959
87	Circadian entrainment_Homo sapiens_hsa04713	0.43375764
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42988574
89	Fatty acid elongation_Homo sapiens_hsa00062	0.40967888
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.40080631
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38710858
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37849974
93	Caffeine metabolism_Homo sapiens_hsa00232	0.36904501
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35745495
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35713862
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33836785
97	* Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33720070
98	Serotonergic synapse_Homo sapiens_hsa04726	0.33678466
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.31389038
100	Fatty acid degradation_Homo sapiens_hsa00071	0.28381227

SPDYE3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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