SPDYE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein targeting to Golgi (GO:0000042)7.43627929
2establishment of protein localization to Golgi (GO:0072600)7.20019127
3retrograde transport, vesicle recycling within Golgi (GO:0000301)7.12347629
4sperm motility (GO:0030317)6.80574523
5acrosome reaction (GO:0007340)6.33101380
6protein localization to Golgi apparatus (GO:0034067)5.99562511
7response to pheromone (GO:0019236)5.92398417
8glomerular visceral epithelial cell development (GO:0072015)5.74130410
9L-fucose catabolic process (GO:0042355)5.47242832
10fucose catabolic process (GO:0019317)5.47242832
11L-fucose metabolic process (GO:0042354)5.47242832
12cellular response to ATP (GO:0071318)5.32533653
13glomerular epithelial cell development (GO:0072310)5.06242015
14multicellular organism reproduction (GO:0032504)5.04207912
15maintenance of gastrointestinal epithelium (GO:0030277)5.02975477
16cellular ketone body metabolic process (GO:0046950)4.96591582
17protein polyglutamylation (GO:0018095)4.73124621
18protein K63-linked deubiquitination (GO:0070536)4.69158140
19spermatid development (GO:0007286)4.64522571
20fusion of sperm to egg plasma membrane (GO:0007342)4.55639124
21rRNA methylation (GO:0031167)4.52819732
22seminiferous tubule development (GO:0072520)4.47638282
23regulation of cilium movement (GO:0003352)4.44929754
24sperm capacitation (GO:0048240)4.35841570
25ketone body metabolic process (GO:1902224)4.30618151
26regulation of ARF GTPase activity (GO:0032312)4.26667736
27reproduction (GO:0000003)4.24259669
28single strand break repair (GO:0000012)4.19252400
29rRNA catabolic process (GO:0016075)4.16230118
30sperm-egg recognition (GO:0035036)4.07287746
31regulation of phosphoprotein phosphatase activity (GO:0043666)4.04511911
32intra-Golgi vesicle-mediated transport (GO:0006891)4.03471728
33protein K48-linked deubiquitination (GO:0071108)3.91934976
34cilium or flagellum-dependent cell motility (GO:0001539)3.88801233
35positive regulation of Rab GTPase activity (GO:0032851)3.88169161
36regulation of Rab GTPase activity (GO:0032313)3.88169161
37Golgi to endosome transport (GO:0006895)3.81990182
38rRNA modification (GO:0000154)3.81801956
39response to lipoprotein particle (GO:0055094)3.71605921
40single fertilization (GO:0007338)3.66137079
41cell-cell recognition (GO:0009988)3.62061735
42GDP-mannose metabolic process (GO:0019673)3.56940307
43epithelial cilium movement (GO:0003351)3.54043420
44indolalkylamine metabolic process (GO:0006586)3.46899228
45coenzyme catabolic process (GO:0009109)3.46431307
46axonemal dynein complex assembly (GO:0070286)3.45373081
47cell wall macromolecule catabolic process (GO:0016998)3.44742683
48phosphatidylethanolamine biosynthetic process (GO:0006646)3.39706554
49plasma membrane fusion (GO:0045026)3.38592452
50male meiosis (GO:0007140)3.36004011
51epithelial structure maintenance (GO:0010669)3.34954126
52regulation of cilium assembly (GO:1902017)3.33775849
53binding of sperm to zona pellucida (GO:0007339)3.33459678
54phosphatidylethanolamine metabolic process (GO:0046337)3.33037772
55cell wall macromolecule metabolic process (GO:0044036)3.32471665
56spermatogenesis (GO:0007283)3.31034584
57male gamete generation (GO:0048232)3.29666634
58regulation of G0 to G1 transition (GO:0070316)3.25170126
59interleukin-6-mediated signaling pathway (GO:0070102)3.24106894
60RNA localization (GO:0006403)3.22567716
61sequestering of metal ion (GO:0051238)3.21739383
62DNA packaging (GO:0006323)3.19923027
63negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.17601463
64isoprenoid biosynthetic process (GO:0008299)3.14559331
65chromosome condensation (GO:0030261)3.12703212
66fucosylation (GO:0036065)3.12690165
67cranial nerve morphogenesis (GO:0021602)3.11834216
68urinary tract smooth muscle contraction (GO:0014848)3.09570460
69appendage development (GO:0048736)3.07622818
70limb development (GO:0060173)3.07622818
71O-glycan processing (GO:0016266)3.06971640
72auditory receptor cell differentiation (GO:0042491)3.06773739
73centriole replication (GO:0007099)3.05088911
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03866982
75gamete generation (GO:0007276)3.03635784
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.01886131
77mannosylation (GO:0097502)2.97822212
78negative regulation of telomere maintenance (GO:0032205)2.97353944
79tryptophan metabolic process (GO:0006568)2.95178947
80fertilization (GO:0009566)2.94148130
81peroxisome fission (GO:0016559)2.93581544
82histone mRNA catabolic process (GO:0071044)2.93024359
83nephron tubule morphogenesis (GO:0072078)2.92922100
84nephron epithelium morphogenesis (GO:0072088)2.92922100
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89794036
86ncRNA catabolic process (GO:0034661)2.88847595
87DNA methylation involved in gamete generation (GO:0043046)2.87592976
88resolution of meiotic recombination intermediates (GO:0000712)2.85624751
89intraciliary transport (GO:0042073)2.84923735
90photoreceptor cell maintenance (GO:0045494)2.84085077
91motile cilium assembly (GO:0044458)2.83098197
92negative regulation of organelle assembly (GO:1902116)2.80347677
93regulation of transcription involved in cell fate commitment (GO:0060850)2.79673369
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79001614
95sexual reproduction (GO:0019953)2.75335800
96cell proliferation in forebrain (GO:0021846)2.73550067
97thrombin receptor signaling pathway (GO:0070493)2.72804137
98cellular response to epidermal growth factor stimulus (GO:0071364)2.72690339
99cilium movement (GO:0003341)2.72562991
100muscle organ morphogenesis (GO:0048644)2.69367088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.06421684
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31306849
3EZH2_22144423_ChIP-Seq_EOC_Human3.19825388
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.98640625
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.97445353
6ER_23166858_ChIP-Seq_MCF-7_Human2.86515824
7ZNF274_21170338_ChIP-Seq_K562_Hela2.67843107
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.65928244
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58266809
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50916413
11DROSHA_22980978_ChIP-Seq_HELA_Human2.34667014
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31754733
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22144483
14WDR5_24793694_ChIP-Seq_LNCAP_Human2.20867623
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.18864228
16GBX2_23144817_ChIP-Seq_PC3_Human2.16832372
17AR_21572438_ChIP-Seq_LNCaP_Human2.15859902
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.08678670
19CBP_20019798_ChIP-Seq_JUKART_Human2.08678670
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07291439
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83803217
22TAF15_26573619_Chip-Seq_HEK293_Human1.83046440
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79701226
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79701226
25VDR_22108803_ChIP-Seq_LS180_Human1.76527361
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63619303
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61860928
28ERA_21632823_ChIP-Seq_H3396_Human1.59443288
29STAT3_23295773_ChIP-Seq_U87_Human1.58568987
30NANOG_20526341_ChIP-Seq_ESCs_Human1.56225934
31P300_19829295_ChIP-Seq_ESCs_Human1.53836189
32SMAD4_21799915_ChIP-Seq_A2780_Human1.50926850
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.49784269
34TAF2_19829295_ChIP-Seq_ESCs_Human1.48275622
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47039798
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.46003022
37TP53_22573176_ChIP-Seq_HFKS_Human1.45663667
38MYC_19829295_ChIP-Seq_ESCs_Human1.45365406
39TCF4_23295773_ChIP-Seq_U87_Human1.45000950
40OCT4_20526341_ChIP-Seq_ESCs_Human1.43734734
41FUS_26573619_Chip-Seq_HEK293_Human1.43493876
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.41432883
43P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39227082
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36691807
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33009746
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32521276
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32447686
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31595794
49BCAT_22108803_ChIP-Seq_LS180_Human1.30074415
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29824722
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.28824611
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28640338
53* TCF4_22108803_ChIP-Seq_LS180_Human1.26638900
54IRF1_19129219_ChIP-ChIP_H3396_Human1.26066929
55RUNX2_22187159_ChIP-Seq_PCA_Human1.25995428
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.25208381
57AR_25329375_ChIP-Seq_VCAP_Human1.24702159
58IGF1R_20145208_ChIP-Seq_DFB_Human1.23656263
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23305164
60RUNX_20019798_ChIP-Seq_JUKART_Human1.22628023
61HOXB7_26014856_ChIP-Seq_BT474_Human1.20021434
62AR_20517297_ChIP-Seq_VCAP_Human1.19843752
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18228990
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18002476
65E2F1_20622854_ChIP-Seq_HELA_Human1.17685663
66NCOR_22424771_ChIP-Seq_293T_Human1.16206364
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15646752
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15060479
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14975482
70CDX2_22108803_ChIP-Seq_LS180_Human1.14742949
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13943600
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13881262
73* RAC3_21632823_ChIP-Seq_H3396_Human1.13060404
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10859281
75TBL1_22424771_ChIP-Seq_293T_Human1.09199063
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08844612
77SMRT_27268052_Chip-Seq_Bcells_Human1.08742931
78BCL6_27268052_Chip-Seq_Bcells_Human1.07884686
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07485830
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06933791
81ETV1_20927104_ChIP-Seq_GIST48_Human1.05052345
82NFYA_21822215_ChIP-Seq_K562_Human1.03751442
83BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.02167928
84P53_21459846_ChIP-Seq_SAOS-2_Human1.01551512
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01170532
86CJUN_26792858_Chip-Seq_BT549_Human1.00715003
87HNFA_21074721_ChIP-Seq_CACO-2_Human1.00333775
88NFYB_21822215_ChIP-Seq_K562_Human1.00069299
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99277932
90SOX2_19829295_ChIP-Seq_ESCs_Human0.97338059
91NANOG_19829295_ChIP-Seq_ESCs_Human0.97338059
92EWS_26573619_Chip-Seq_HEK293_Human0.97205469
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.96790283
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96571832
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96474371
96GATA3_26560356_Chip-Seq_TH1_Human0.96014233
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95733654
98P300_27268052_Chip-Seq_Bcells_Human0.95723775
99RBPJ_21746931_ChIP-Seq_IB4_Human0.95499115
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94604675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.66584263
2MP0008004_abnormal_stomach_pH4.24977724
3MP0001348_abnormal_lacrimal_gland4.03771672
4MP0003045_fibrosis2.81565697
5MP0000465_gastrointestinal_hemorrhage2.61713825
6MP0003698_abnormal_male_reproductive2.61363713
7MP0005253_abnormal_eye_physiology2.42786259
8MP0005551_abnormal_eye_electrophysiolog2.35942019
9MP0001485_abnormal_pinna_reflex2.32472972
10MP0005423_abnormal_somatic_nervous2.32107231
11MP0002822_catalepsy2.25554957
12MP0001929_abnormal_gametogenesis2.20062683
13MP0003693_abnormal_embryo_hatching2.16593649
14MP0003879_abnormal_hair_cell2.12718586
15MP0000470_abnormal_stomach_morphology2.06407087
16MP0003300_gastrointestinal_ulcer1.95198299
17MP0004742_abnormal_vestibular_system1.90154736
18MP0005377_hearing/vestibular/ear_phenot1.84132878
19MP0003878_abnormal_ear_physiology1.84132878
20MP0003011_delayed_dark_adaptation1.81941061
21MP0005408_hypopigmentation1.77180944
22MP0001486_abnormal_startle_reflex1.71084926
23MP0003646_muscle_fatigue1.69201785
24MP0004145_abnormal_muscle_electrophysio1.68832563
25MP0000569_abnormal_digit_pigmentation1.65456062
26MP0001765_abnormal_ion_homeostasis1.65167424
27MP0003890_abnormal_embryonic-extraembry1.60286359
28MP0001664_abnormal_digestion1.59571940
29MP0004084_abnormal_cardiac_muscle1.50136929
30MP0001270_distended_abdomen1.46080327
31MP0006072_abnormal_retinal_apoptosis1.39414070
32MP0001963_abnormal_hearing_physiology1.37948873
33MP0008961_abnormal_basal_metabolism1.37168584
34MP0010155_abnormal_intestine_physiology1.36328450
35MP0000026_abnormal_inner_ear1.35446977
36MP0001666_abnormal_nutrient_absorption1.35095806
37MP0005379_endocrine/exocrine_gland_phen1.32543834
38MP0003866_abnormal_defecation1.25376855
39MP0004885_abnormal_endolymph1.24051786
40MP0002102_abnormal_ear_morphology1.23545007
41MP0002229_neurodegeneration1.22838548
42MP0002098_abnormal_vibrissa_morphology1.21936762
43MP0004142_abnormal_muscle_tone1.21851311
44MP0002127_abnormal_cardiovascular_syste1.20799496
45MP0004036_abnormal_muscle_relaxation1.20370787
46MP0008995_early_reproductive_senescence1.19064613
47MP0003880_abnormal_central_pattern1.18414466
48MP0002168_other_aberrant_phenotype1.16705286
49MP0008775_abnormal_heart_ventricle1.16019604
50MP0005503_abnormal_tendon_morphology1.12664604
51MP0001529_abnormal_vocalization1.11844362
52MP0005670_abnormal_white_adipose1.09602791
53MP0002736_abnormal_nociception_after1.06903381
54MP0009764_decreased_sensitivity_to1.06893928
55MP0002161_abnormal_fertility/fecundity1.06225422
56MP0000579_abnormal_nail_morphology1.04552132
57MP0003195_calcinosis1.02354681
58MP0005310_abnormal_salivary_gland1.01590523
59MP0002210_abnormal_sex_determination1.01274902
60MP0004147_increased_porphyrin_level0.99828360
61MP0002184_abnormal_innervation0.98136170
62MP0001968_abnormal_touch/_nociception0.94851192
63MP0001501_abnormal_sleep_pattern0.93820986
64MP0005391_vision/eye_phenotype0.92766835
65MP0005395_other_phenotype0.92764885
66MP0005646_abnormal_pituitary_gland0.91940956
67MP0002160_abnormal_reproductive_system0.91553456
68MP0008877_abnormal_DNA_methylation0.91333773
69MP0009785_altered_susceptibility_to0.88992546
70MP0000230_abnormal_systemic_arterial0.87655621
71MP0005275_abnormal_skin_tensile0.86305266
72MP0005360_urolithiasis0.85907388
73MP0002557_abnormal_social/conspecific_i0.85177244
74MP0005083_abnormal_biliary_tract0.84875194
75MP0002067_abnormal_sensory_capabilities0.81481581
76MP0000733_abnormal_muscle_development0.79701783
77MP0002132_abnormal_respiratory_system0.77957445
78MP0001663_abnormal_digestive_system0.77918618
79MP0003279_aneurysm0.76185603
80MP0003091_abnormal_cell_migration0.75731402
81MP0000747_muscle_weakness0.75478650
82MP0005508_abnormal_skeleton_morphology0.74879200
83MP0002751_abnormal_autonomic_nervous0.72733705
84MP0003718_maternal_effect0.70851638
85MP0002272_abnormal_nervous_system0.69346730
86MP0005636_abnormal_mineral_homeostasis0.67729150
87MP0001835_abnormal_antigen_presentation0.67224183
88MP0000049_abnormal_middle_ear0.66657635
89MP0002572_abnormal_emotion/affect_behav0.66646643
90MP0000653_abnormal_sex_gland0.66513313
91MP0005645_abnormal_hypothalamus_physiol0.66503509
92MP0002638_abnormal_pupillary_reflex0.65741764
93MP0001145_abnormal_male_reproductive0.65669935
94MP0002752_abnormal_somatic_nervous0.65530621
95MP0000955_abnormal_spinal_cord0.65322071
96MP0005386_behavior/neurological_phenoty0.64400278
97MP0004924_abnormal_behavior0.64400278
98MP0000566_synostosis0.62574384
99MP0000427_abnormal_hair_cycle0.60054422
100MP0002249_abnormal_larynx_morphology0.59498411

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of DNA repair (HP:0003254)4.97419666
2Reduced antithrombin III activity (HP:0001976)4.58001485
3Abnormality of lateral ventricle (HP:0030047)4.03148011
4Abnormal glycosylation (HP:0012345)3.71996059
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.71996059
6Abnormal protein N-linked glycosylation (HP:0012347)3.71996059
7Abnormal protein glycosylation (HP:0012346)3.71996059
8Mesomelia (HP:0003027)3.58127620
9Type I transferrin isoform profile (HP:0003642)3.55419762
10Absent/shortened dynein arms (HP:0200106)3.52891483
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.52891483
12Hypoproteinemia (HP:0003075)3.47323713
13Enlarged epiphyses (HP:0010580)3.34796550
14Abnormality of the renal cortex (HP:0011035)3.27762397
15Renal cortical cysts (HP:0000803)3.26800067
16Heterotopia (HP:0002282)3.19418739
17Congenital sensorineural hearing impairment (HP:0008527)3.13264102
18Macular degeneration (HP:0000608)3.00106803
19Chronic hepatic failure (HP:0100626)2.92502381
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.88102205
21Tubulointerstitial nephritis (HP:0001970)2.82897111
22Attenuation of retinal blood vessels (HP:0007843)2.82642943
23Retinal dysplasia (HP:0007973)2.70530365
24Hyperkalemia (HP:0002153)2.70406508
25Cerebellar dysplasia (HP:0007033)2.69486988
26Hypoplastic ischia (HP:0003175)2.69135635
27Abnormality of the renal medulla (HP:0100957)2.63442853
28Abnormal rod and cone electroretinograms (HP:0008323)2.63350175
29Hypochromic microcytic anemia (HP:0004840)2.60410879
30Nephronophthisis (HP:0000090)2.60208388
31Methylmalonic acidemia (HP:0002912)2.58821428
32Severe visual impairment (HP:0001141)2.58285384
33Peritonitis (HP:0002586)2.52604234
34Type II lissencephaly (HP:0007260)2.52269064
35Bell-shaped thorax (HP:0001591)2.48578166
36Abnormality of the aortic arch (HP:0012303)2.47156672
37Abnormality of dentin (HP:0010299)2.46759106
38Impulsivity (HP:0100710)2.42905241
39Short tibia (HP:0005736)2.42277264
40Stomatitis (HP:0010280)2.40119922
41Delayed CNS myelination (HP:0002188)2.39630071
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.37146884
43Increased corneal curvature (HP:0100692)2.36998192
44Keratoconus (HP:0000563)2.36998192
45Spinal muscular atrophy (HP:0007269)2.36226323
46Abnormality of chloride homeostasis (HP:0011422)2.36178866
47Bony spicule pigmentary retinopathy (HP:0007737)2.35706690
48Abnormality of the epiphysis of the femoral head (HP:0010574)2.34785755
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.33119845
50Abnormality of the fingertips (HP:0001211)2.31352046
51Prolonged neonatal jaundice (HP:0006579)2.30323949
52Abnormality of the preputium (HP:0100587)2.29952670
53Abnormality of femoral epiphyses (HP:0006499)2.27850560
54Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.27850560
55Duplicated collecting system (HP:0000081)2.24702393
56Abnormality of the femoral head (HP:0003368)2.22249391
57Widely patent fontanelles and sutures (HP:0004492)2.17492693
58Esophageal atresia (HP:0002032)2.17132340
59Poor coordination (HP:0002370)2.17072422
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16592546
61Tibial bowing (HP:0002982)2.15830385
62Abnormality of the vertebral endplates (HP:0005106)2.14975330
63Abnormal respiratory motile cilium morphology (HP:0005938)2.14820794
64Abnormal respiratory epithelium morphology (HP:0012253)2.14820794
65Hypoplasia of the pons (HP:0012110)2.13643537
66Prolonged QT interval (HP:0001657)2.13350211
67Flattened epiphyses (HP:0003071)2.12595618
68Abnormality of the ileum (HP:0001549)2.11546912
69Progressive cerebellar ataxia (HP:0002073)2.08582976
70Pancreatic fibrosis (HP:0100732)2.08448759
71Abnormality of the ischium (HP:0003174)2.06985982
72Irregular vertebral endplates (HP:0003301)2.06745970
73Long clavicles (HP:0000890)2.05609358
74Abnormal ciliary motility (HP:0012262)2.05378939
75Abnormality of the renal collecting system (HP:0004742)2.05210175
76Abnormal biliary tract morphology (HP:0012440)2.04187039
77Gastrointestinal atresia (HP:0002589)2.03625902
78Thoracic kyphosis (HP:0002942)2.02144846
79Cystic liver disease (HP:0006706)2.00330315
80Abnormality of vitamin B metabolism (HP:0004340)2.00313544
81Truncal obesity (HP:0001956)1.99992412
82Decreased central vision (HP:0007663)1.99587397
83Clubbing of toes (HP:0100760)1.97960171
84Adrenal hypoplasia (HP:0000835)1.97470637
85Abnormality of the nasal septum (HP:0000419)1.95999630
86Hypophosphatemic rickets (HP:0004912)1.94844667
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94519221
88Short 4th metacarpal (HP:0010044)1.91543797
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91543797
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90542971
91Absent thumb (HP:0009777)1.90273512
92Pancreatic cysts (HP:0001737)1.90200299
93Vitreoretinal degeneration (HP:0000655)1.87896989
94Cone-rod dystrophy (HP:0000548)1.86874247
95Abnormality of the right ventricle (HP:0001707)1.86839887
96Abnormality of chromosome stability (HP:0003220)1.86275126
97Abnormality of the carotid arteries (HP:0005344)1.84977779
98Meckel diverticulum (HP:0002245)1.83098541
99Hypoplasia of dental enamel (HP:0006297)1.78376152
100Metaphyseal dysplasia (HP:0100255)1.78123594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.83545063
2MST1R4.36982859
3MET4.33757516
4PLK43.55040195
5MAP4K23.39954315
6MUSK3.10688964
7BMPR1B2.66868345
8NME12.52234554
9STK162.29539255
10WNK12.21158305
11PINK12.08153787
12STK381.87243538
13NEK91.84945744
14STK391.82843263
15FRK1.80971694
16IKBKE1.71453507
17CDK121.67169427
18BLK1.62538487
19PDK21.52920025
20MAP3K61.43371614
21TIE11.37990640
22INSRR1.37324311
23PLK21.35792572
24TLK11.33384418
25ADRBK21.26530428
26LMTK21.23750306
27OXSR11.22401583
28NEK61.13883121
29TAOK31.12382181
30DDR21.12376151
31MARK31.11867045
32EPHA31.11296488
33PAK31.05516141
34ZAK1.04506608
35NEK21.03479480
36GRK11.03415535
37ERBB21.02851598
38PBK1.02391474
39MAP2K71.02018073
40IKBKB0.99115852
41MAP3K40.96533122
42JAK30.95764362
43BCKDK0.89056811
44PIM20.88481574
45STK38L0.87391336
46CAMK1D0.85760285
47DYRK1B0.84072852
48PTK2B0.80055413
49CHUK0.78164970
50CAMK1G0.75803160
51ERN10.75622178
52MKNK10.69897091
53CDK60.69258885
54PRKD30.63416124
55EIF2AK30.62874196
56ZAP700.60205192
57MAP2K60.59973718
58TNK20.57458884
59PRKCE0.56408559
60MAPK150.54321088
61MAPK10.50893621
62MARK10.50320409
63PRKG20.48340863
64TEC0.48328413
65CAMK40.47176796
66OBSCN0.47150030
67MAPK100.45930398
68BRD40.45686564
69FER0.42226344
70SYK0.40164261
71MAP3K50.39397137
72ATR0.38679168
73PIM10.38385028
74GSK3B0.37987511
75TXK0.37821149
76RPS6KA60.37631970
77NTRK20.37319723
78HCK0.37230257
79SGK10.37099070
80RPS6KC10.35574689
81RPS6KL10.35574689
82PDK10.35514548
83IGF1R0.35502171
84PRKG10.35479720
85LYN0.35115944
86WNK30.34917650
87CDK20.33747860
88KIT0.32895235
89CDK10.32764823
90RPS6KA50.32464970
91RPS6KA20.32302152
92CASK0.31099320
93CDK90.30253947
94CSNK1A10.30094877
95PRKACA0.29808785
96CDK30.28351403
97MAPK30.28313456
98AKT10.27973886
99CHEK10.27496839
100BTK0.27280705

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.90601035
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.28175104
3Olfactory transduction_Homo sapiens_hsa047403.10613630
4* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.71576188
5Butanoate metabolism_Homo sapiens_hsa006502.44008028
6Taste transduction_Homo sapiens_hsa047422.37582008
7ABC transporters_Homo sapiens_hsa020102.28901827
8Fanconi anemia pathway_Homo sapiens_hsa034602.26740882
9Tryptophan metabolism_Homo sapiens_hsa003802.21367530
10* Oocyte meiosis_Homo sapiens_hsa041141.89396355
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69417575
12RNA transport_Homo sapiens_hsa030131.65297417
13Renin-angiotensin system_Homo sapiens_hsa046141.62338199
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60920095
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57209620
16Lysine degradation_Homo sapiens_hsa003101.55900497
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53796223
18Propanoate metabolism_Homo sapiens_hsa006401.53415005
19Salivary secretion_Homo sapiens_hsa049701.47257195
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37137447
21Peroxisome_Homo sapiens_hsa041461.37050041
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37037986
23N-Glycan biosynthesis_Homo sapiens_hsa005101.32264984
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30351411
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21957803
26Fatty acid degradation_Homo sapiens_hsa000711.16193740
27Vitamin digestion and absorption_Homo sapiens_hsa049771.12356258
28Protein digestion and absorption_Homo sapiens_hsa049741.09077546
29Nitrogen metabolism_Homo sapiens_hsa009101.07570086
30Glycerolipid metabolism_Homo sapiens_hsa005611.04296491
31Linoleic acid metabolism_Homo sapiens_hsa005911.03856253
32Arginine and proline metabolism_Homo sapiens_hsa003301.03581640
33beta-Alanine metabolism_Homo sapiens_hsa004101.01507117
34Gap junction_Homo sapiens_hsa045400.98202992
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97505974
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96371811
37Histidine metabolism_Homo sapiens_hsa003400.95202407
38Thyroid hormone synthesis_Homo sapiens_hsa049180.94543922
39Circadian entrainment_Homo sapiens_hsa047130.93454480
40Fatty acid biosynthesis_Homo sapiens_hsa000610.92481544
41African trypanosomiasis_Homo sapiens_hsa051430.90565165
42Retinol metabolism_Homo sapiens_hsa008300.89216373
43Basal transcription factors_Homo sapiens_hsa030220.88420369
44Fructose and mannose metabolism_Homo sapiens_hsa000510.88199282
45Fatty acid elongation_Homo sapiens_hsa000620.87203800
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.85828858
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85294858
48Base excision repair_Homo sapiens_hsa034100.85037977
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81391663
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80503550
51Herpes simplex infection_Homo sapiens_hsa051680.80082912
52cAMP signaling pathway_Homo sapiens_hsa040240.71111215
53Calcium signaling pathway_Homo sapiens_hsa040200.70576601
54Serotonergic synapse_Homo sapiens_hsa047260.69942038
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69799063
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.69129510
57Long-term depression_Homo sapiens_hsa047300.65991989
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64966330
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64189025
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.63855471
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63793876
62Mineral absorption_Homo sapiens_hsa049780.62338633
63Chemical carcinogenesis_Homo sapiens_hsa052040.62181638
64Primary immunodeficiency_Homo sapiens_hsa053400.61945628
65Ether lipid metabolism_Homo sapiens_hsa005650.61376481
66Dorso-ventral axis formation_Homo sapiens_hsa043200.61151691
67Arachidonic acid metabolism_Homo sapiens_hsa005900.60373081
68Phototransduction_Homo sapiens_hsa047440.58972352
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58536231
70Hedgehog signaling pathway_Homo sapiens_hsa043400.56528966
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.56214816
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53167978
73Renin secretion_Homo sapiens_hsa049240.52592282
74Platelet activation_Homo sapiens_hsa046110.49039120
75Glutamatergic synapse_Homo sapiens_hsa047240.48918378
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48038712
77Homologous recombination_Homo sapiens_hsa034400.47450236
78Allograft rejection_Homo sapiens_hsa053300.45525796
79Type II diabetes mellitus_Homo sapiens_hsa049300.43717584
80Insulin secretion_Homo sapiens_hsa049110.43260267
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.43239046
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42407746
83Inositol phosphate metabolism_Homo sapiens_hsa005620.41829091
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40965755
85Type I diabetes mellitus_Homo sapiens_hsa049400.40630125
86Graft-versus-host disease_Homo sapiens_hsa053320.40291731
87Steroid biosynthesis_Homo sapiens_hsa001000.39699145
88Gastric acid secretion_Homo sapiens_hsa049710.37938293
89Autoimmune thyroid disease_Homo sapiens_hsa053200.37194664
90Phagosome_Homo sapiens_hsa041450.35242867
91Pancreatic secretion_Homo sapiens_hsa049720.34629225
92mRNA surveillance pathway_Homo sapiens_hsa030150.34624810
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33990360
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33162005
95Galactose metabolism_Homo sapiens_hsa000520.32469190
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.31205959
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30628371
98Influenza A_Homo sapiens_hsa051640.30442826
99Antigen processing and presentation_Homo sapiens_hsa046120.30416299
100Estrogen signaling pathway_Homo sapiens_hsa049150.30407115

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