ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.94507934
2	establishment of protein localization to Golgi (GO:0072600)	4.39277033
3	tryptophan catabolic process (GO:0006569)	4.24894496
4	indole-containing compound catabolic process (GO:0042436)	4.24894496
5	indolalkylamine catabolic process (GO:0046218)	4.24894496
6	kynurenine metabolic process (GO:0070189)	4.03257795
7	replication fork processing (GO:0031297)	3.95413960
8	neural tube formation (GO:0001841)	3.94765158
9	tryptophan metabolic process (GO:0006568)	3.91844971
10	protein targeting to Golgi (GO:0000042)	3.88364993
11	DNA deamination (GO:0045006)	3.69483799
12	indolalkylamine metabolic process (GO:0006586)	3.67553569
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.66201628
14	multicellular organism reproduction (GO:0032504)	3.51808863
15	centriole replication (GO:0007099)	3.47409520
16	double-strand break repair via homologous recombination (GO:0000724)	3.47321412
17	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.46354744
18	recombinational repair (GO:0000725)	3.45282958
19	mannosylation (GO:0097502)	3.44937934
20	cytochrome complex assembly (GO:0017004)	3.39258627
21	intra-S DNA damage checkpoint (GO:0031573)	3.38391381
22	photoreceptor cell maintenance (GO:0045494)	3.36982859
23	positive regulation of mRNA catabolic process (GO:0061014)	3.33804429
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.25500181
25	protein localization to Golgi apparatus (GO:0034067)	3.24541340
26	respiratory chain complex IV assembly (GO:0008535)	3.17356155
27	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.16057759
28	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.16057759
29	snRNA transcription (GO:0009301)	3.12868841
30	DNA integration (GO:0015074)	3.12563299
31	protein complex biogenesis (GO:0070271)	3.09868497
32	regulation of hexokinase activity (GO:1903299)	3.08859850
33	regulation of glucokinase activity (GO:0033131)	3.08859850
34	prenylation (GO:0097354)	3.08033662
35	protein prenylation (GO:0018342)	3.08033662
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04846391
37	axoneme assembly (GO:0035082)	3.04691126
38	histone H3-K4 trimethylation (GO:0080182)	3.04453391
39	regulation of MHC class I biosynthetic process (GO:0045343)	3.04200888
40	DNA demethylation (GO:0080111)	3.03765560
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.02628798
42	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.01349259
43	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.01349259
44	response to pheromone (GO:0019236)	3.01133720
45	sperm motility (GO:0030317)	3.00453979
46	cellular ketone body metabolic process (GO:0046950)	2.99697878
47	natural killer cell activation involved in immune response (GO:0002323)	2.98652162
48	acrosome reaction (GO:0007340)	2.98386477
49	auditory receptor cell stereocilium organization (GO:0060088)	2.98092898
50	regulation of cilium movement (GO:0003352)	2.95732486
51	L-fucose metabolic process (GO:0042354)	2.92885151
52	L-fucose catabolic process (GO:0042355)	2.92885151
53	fucose catabolic process (GO:0019317)	2.92885151
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91976965
55	NADH dehydrogenase complex assembly (GO:0010257)	2.91976965
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91976965
57	male meiosis (GO:0007140)	2.90219464
58	nonmotile primary cilium assembly (GO:0035058)	2.87341361
59	peptidyl-lysine trimethylation (GO:0018023)	2.85577238
60	ketone body metabolic process (GO:1902224)	2.78674764
61	regulation of mRNA catabolic process (GO:0061013)	2.75448950
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74679547
63	histone H2A acetylation (GO:0043968)	2.74044165
64	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.73875432
65	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.73875432
66	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71741302
67	amino acid salvage (GO:0043102)	2.71464442
68	L-methionine salvage (GO:0071267)	2.71464442
69	L-methionine biosynthetic process (GO:0071265)	2.71464442
70	tachykinin receptor signaling pathway (GO:0007217)	2.69310168
71	positive regulation of mRNA metabolic process (GO:1903313)	2.66900958
72	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.66562371
73	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.66562371
74	regulation of translation, ncRNA-mediated (GO:0045974)	2.66562371
75	epithelial cilium movement (GO:0003351)	2.63188919
76	reciprocal meiotic recombination (GO:0007131)	2.62325364
77	reciprocal DNA recombination (GO:0035825)	2.62325364
78	intra-Golgi vesicle-mediated transport (GO:0006891)	2.60838691
79	NAD biosynthetic process (GO:0009435)	2.59442805
80	cilium organization (GO:0044782)	2.58873558
81	negative regulation of cAMP-mediated signaling (GO:0043951)	2.58550329
82	anterograde synaptic vesicle transport (GO:0048490)	2.58452659
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58258524
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.58258524
85	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57637824
86	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.57497999
87	protein K6-linked ubiquitination (GO:0085020)	2.57152986
88	DNA strand renaturation (GO:0000733)	2.56159728
89	detection of light stimulus involved in visual perception (GO:0050908)	2.55812428
90	detection of light stimulus involved in sensory perception (GO:0050962)	2.55812428
91	microtubule anchoring (GO:0034453)	2.55429983
92	positive regulation of granulocyte differentiation (GO:0030854)	2.54903662
93	response to misfolded protein (GO:0051788)	2.54136817
94	methionine biosynthetic process (GO:0009086)	2.53686970
95	cellular biogenic amine catabolic process (GO:0042402)	2.52746626
96	amine catabolic process (GO:0009310)	2.52746626
97	phosphatidylethanolamine metabolic process (GO:0046337)	2.51924617
98	cilium assembly (GO:0042384)	2.49409110
99	DNA dealkylation (GO:0035510)	2.48781659
100	mismatch repair (GO:0006298)	2.47162123

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68806105
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97559147
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.96382150
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.88252832
5	VDR_22108803_ChIP-Seq_LS180_Human	2.65613792
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59749290
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.44030791
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34534206
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32366983
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.30238563
11	FUS_26573619_Chip-Seq_HEK293_Human	2.20803919
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14685577
13	EWS_26573619_Chip-Seq_HEK293_Human	2.12298342
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04154761
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.01945015
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94446155
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.92206019
18	P300_19829295_ChIP-Seq_ESCs_Human	1.89944996
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85567570
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85386816
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85051475
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81212382
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.77215249
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77018730
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.76778834
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76778834
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75109976
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70743130
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69560192
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62434187
31	STAT3_23295773_ChIP-Seq_U87_Human	1.58897518
32	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.53706547
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.52699837
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52610648
35	TCF4_23295773_ChIP-Seq_U87_Human	1.51769522
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50695774
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50695774
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.48918563
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46881172
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45938596
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43729416
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41432507
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41366618
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41269800
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.40954900
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39373652
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.38817433
48	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.36904581
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.35145042
50	GATA3_26560356_Chip-Seq_TH2_Human	1.34148162
51	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32612175
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31897669
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30108017
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.29645970
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.28234373
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26969397
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26265580
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25072218
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24956745
60	AR_25329375_ChIP-Seq_VCAP_Human	1.24775034
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24653858
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20998500
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20520763
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19872831
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.18922280
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18841322
67	FOXP3_21729870_ChIP-Seq_TREG_Human	1.18322095
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18255222
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18255222
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16938536
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16594628
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14656690
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14656690
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13229175
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11921172
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11639471
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11228499
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.10368920
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09580115
80	AR_21572438_ChIP-Seq_LNCaP_Human	1.09100682
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08858469
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08627147
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08501964
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08369930
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07482183
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07270700
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06586952
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05858447
89	NCOR_22424771_ChIP-Seq_293T_Human	1.04958003
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.04948240
91	RXR_22108803_ChIP-Seq_LS180_Human	1.04558665
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04122563
93	* AR_20517297_ChIP-Seq_VCAP_Human	1.03615113
94	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03596060
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03160226
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03073070
97	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.01012133
98	GATA3_27048872_Chip-Seq_THYMUS_Human	1.00811259
99	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00738506
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00596432

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.47843786
2	MP0000569_abnormal_digit_pigmentation	3.18247367
3	MP0008057_abnormal_DNA_replication	3.12414092
4	MP0008877_abnormal_DNA_methylation	3.08927492
5	MP0008058_abnormal_DNA_repair	2.85985348
6	MP0006072_abnormal_retinal_apoptosis	2.66365995
7	MP0010094_abnormal_chromosome_stability	2.62705918
8	MP0005551_abnormal_eye_electrophysiolog	2.44863711
9	MP0005253_abnormal_eye_physiology	2.27758553
10	MP0001984_abnormal_olfaction	2.25980316
11	MP0004043_abnormal_pH_regulation	2.21358729
12	MP0002102_abnormal_ear_morphology	2.19244306
13	MP0003787_abnormal_imprinting	2.12084488
14	MP0001968_abnormal_touch/_nociception	1.92462866
15	MP0000427_abnormal_hair_cycle	1.91850520
16	MP0004147_increased_porphyrin_level	1.91336517
17	MP0005410_abnormal_fertilization	1.76942291
18	MP0002638_abnormal_pupillary_reflex	1.76904240
19	MP0008995_early_reproductive_senescence	1.71023598
20	MP0009697_abnormal_copulation	1.63545352
21	MP0003195_calcinosis	1.62233306
22	MP0003136_yellow_coat_color	1.60629619
23	MP0005174_abnormal_tail_pigmentation	1.49425478
24	MP0000383_abnormal_hair_follicle	1.48204550
25	MP0005645_abnormal_hypothalamus_physiol	1.46883723
26	MP0003786_premature_aging	1.45089482
27	MP0003718_maternal_effect	1.39757100
28	MP0002751_abnormal_autonomic_nervous	1.39011797
29	MP0008872_abnormal_physiological_respon	1.36788047
30	MP0002735_abnormal_chemical_nociception	1.36066020
31	MP0002653_abnormal_ependyma_morphology	1.35529858
32	MP0010386_abnormal_urinary_bladder	1.33141154
33	MP0001929_abnormal_gametogenesis	1.32105113
34	MP0005075_abnormal_melanosome_morpholog	1.29089269
35	MP0003698_abnormal_male_reproductive	1.25984882
36	MP0008875_abnormal_xenobiotic_pharmacok	1.23107322
37	MP0009780_abnormal_chondrocyte_physiolo	1.22347364
38	MP0002736_abnormal_nociception_after	1.21549349
39	MP0001485_abnormal_pinna_reflex	1.20374256
40	MP0002928_abnormal_bile_duct	1.17250713
41	MP0009046_muscle_twitch	1.16105969
42	MP0005083_abnormal_biliary_tract	1.15254827
43	MP0003646_muscle_fatigue	1.14713372
44	MP0005671_abnormal_response_to	1.13262796
45	MP0002396_abnormal_hematopoietic_system	1.12960759
46	MP0006276_abnormal_autonomic_nervous	1.10300408
47	MP0005646_abnormal_pituitary_gland	1.07130723
48	MP0001486_abnormal_startle_reflex	1.06753242
49	MP0003252_abnormal_bile_duct	1.02453808
50	MP0005171_absent_coat_pigmentation	1.02040349
51	MP0002166_altered_tumor_susceptibility	1.01898801
52	MP0002163_abnormal_gland_morphology	0.98256654
53	MP0005386_behavior/neurological_phenoty	0.96727989
54	MP0004924_abnormal_behavior	0.96727989
55	MP0008789_abnormal_olfactory_epithelium	0.96511227
56	MP0001764_abnormal_homeostasis	0.95229317
57	MP0002210_abnormal_sex_determination	0.94042041
58	MP0002837_dystrophic_cardiac_calcinosis	0.93930872
59	MP0006035_abnormal_mitochondrial_morpho	0.93412087
60	MP0000647_abnormal_sebaceous_gland	0.92624265
61	MP0004142_abnormal_muscle_tone	0.92238789
62	MP0002095_abnormal_skin_pigmentation	0.91022048
63	MP0003693_abnormal_embryo_hatching	0.89578465
64	MP0008961_abnormal_basal_metabolism	0.89296389
65	MP0000653_abnormal_sex_gland	0.87894217
66	MP0005310_abnormal_salivary_gland	0.87084484
67	MP0002938_white_spotting	0.86904184
68	MP0008775_abnormal_heart_ventricle	0.85637641
69	MP0002138_abnormal_hepatobiliary_system	0.85480397
70	MP0005379_endocrine/exocrine_gland_phen	0.84967580
71	MP0003763_abnormal_thymus_physiology	0.83921365
72	MP0001800_abnormal_humoral_immune	0.82757429
73	MP0006036_abnormal_mitochondrial_physio	0.82365393
74	MP0002876_abnormal_thyroid_physiology	0.82074775
75	MP0003943_abnormal_hepatobiliary_system	0.81888227
76	MP0001970_abnormal_pain_threshold	0.81278707
77	MP0002572_abnormal_emotion/affect_behav	0.79557663
78	MP0002229_neurodegeneration	0.78429911
79	MP0005220_abnormal_exocrine_pancreas	0.78254938
80	MP0009745_abnormal_behavioral_response	0.77896608
81	MP0001145_abnormal_male_reproductive	0.77370416
82	MP0008007_abnormal_cellular_replicative	0.76869160
83	MP0004885_abnormal_endolymph	0.76589950
84	MP0002067_abnormal_sensory_capabilities	0.76176533
85	MP0003121_genomic_imprinting	0.75959867
86	MP0002733_abnormal_thermal_nociception	0.75901837
87	MP0004381_abnormal_hair_follicle	0.75592727
88	MP0000230_abnormal_systemic_arterial	0.75244871
89	MP0001501_abnormal_sleep_pattern	0.74874686
90	MP0001963_abnormal_hearing_physiology	0.74838603
91	MP0000465_gastrointestinal_hemorrhage	0.74619161
92	MP0001324_abnormal_eye_pigmentation	0.74581447
93	MP0004133_heterotaxia	0.73173844
94	MP0005391_vision/eye_phenotype	0.72991304
95	MP0001529_abnormal_vocalization	0.71959274
96	MP0005167_abnormal_blood-brain_barrier	0.71484261
97	MP0010678_abnormal_skin_adnexa	0.70309010
98	MP0002006_tumorigenesis	0.69530213
99	MP0000538_abnormal_urinary_bladder	0.68956455
100	MP0002272_abnormal_nervous_system	0.67544700

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.93042956
2	Pancreatic cysts (HP:0001737)	3.89248788
3	Pancreatic fibrosis (HP:0100732)	3.67630161
4	Medial flaring of the eyebrow (HP:0010747)	3.48254616
5	Gaze-evoked nystagmus (HP:0000640)	3.30684814
6	True hermaphroditism (HP:0010459)	3.28500112
7	Abnormality of midbrain morphology (HP:0002418)	3.19917308
8	Molar tooth sign on MRI (HP:0002419)	3.19917308
9	Attenuation of retinal blood vessels (HP:0007843)	3.17353083
10	Congenital stationary night blindness (HP:0007642)	3.12527342
11	Nephronophthisis (HP:0000090)	3.04236887
12	Congenital primary aphakia (HP:0007707)	3.03624139
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.00920072
14	Gait imbalance (HP:0002141)	2.99864307
15	Abnormality of the renal medulla (HP:0100957)	2.90678394
16	Thyroiditis (HP:0100646)	2.88071108
17	Abnormality of the renal cortex (HP:0011035)	2.87772572
18	Cerebellar dysplasia (HP:0007033)	2.85199411
19	Fair hair (HP:0002286)	2.73705804
20	Nephrogenic diabetes insipidus (HP:0009806)	2.71868099
21	Tubulointerstitial nephritis (HP:0001970)	2.68324993
22	Genetic anticipation (HP:0003743)	2.66631525
23	Severe visual impairment (HP:0001141)	2.64240295
24	Decreased central vision (HP:0007663)	2.56169009
25	Cystic liver disease (HP:0006706)	2.56039092
26	Chronic hepatic failure (HP:0100626)	2.52939514
27	Severe combined immunodeficiency (HP:0004430)	2.44444027
28	Poor coordination (HP:0002370)	2.42047712
29	Genital tract atresia (HP:0001827)	2.29660569
30	Type II lissencephaly (HP:0007260)	2.27684283
31	Astigmatism (HP:0000483)	2.27069382
32	Hypoproteinemia (HP:0003075)	2.26330195
33	Abnormality of B cell number (HP:0010975)	2.22654691
34	Bile duct proliferation (HP:0001408)	2.20073977
35	Abnormal biliary tract physiology (HP:0012439)	2.20073977
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19976892
37	Chromsome breakage (HP:0040012)	2.18341102
38	Hepatocellular necrosis (HP:0001404)	2.17637276
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.17421517
40	Absent speech (HP:0001344)	2.14469992
41	Abnormality of chromosome stability (HP:0003220)	2.13872309
42	Vaginal atresia (HP:0000148)	2.12385481
43	Progressive inability to walk (HP:0002505)	2.11741097
44	Abolished electroretinogram (ERG) (HP:0000550)	2.10906307
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.10423452
46	Ependymoma (HP:0002888)	2.07831120
47	Volvulus (HP:0002580)	2.07521007
48	Generalized hypopigmentation of hair (HP:0011358)	2.07474001
49	Intestinal atresia (HP:0011100)	2.06629227
50	Congenital hepatic fibrosis (HP:0002612)	2.06431127
51	Broad-based gait (HP:0002136)	2.06001966
52	Clubbing of toes (HP:0100760)	2.05382360
53	Renal cortical cysts (HP:0000803)	2.04529667
54	Sloping forehead (HP:0000340)	2.02920517
55	Postaxial foot polydactyly (HP:0001830)	2.02318081
56	Abnormal protein glycosylation (HP:0012346)	2.01809446
57	Abnormal glycosylation (HP:0012345)	2.01809446
58	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01809446
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.01809446
60	Clumsiness (HP:0002312)	2.01547671
61	Panhypogammaglobulinemia (HP:0003139)	2.00675899
62	Progressive cerebellar ataxia (HP:0002073)	1.99872064
63	Increased CSF lactate (HP:0002490)	1.98979362
64	Tubular atrophy (HP:0000092)	1.97874735
65	Concave nail (HP:0001598)	1.96752976
66	Stomatitis (HP:0010280)	1.95088603
67	Abnormality of the astrocytes (HP:0100707)	1.94922059
68	Astrocytoma (HP:0009592)	1.94922059
69	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.94233440
70	Eosinophilia (HP:0001880)	1.94058818
71	Abnormality of the ileum (HP:0001549)	1.93777709
72	Abnormality of eosinophils (HP:0001879)	1.93687586
73	Widely spaced teeth (HP:0000687)	1.93447339
74	B lymphocytopenia (HP:0010976)	1.93289489
75	Abnormality of macular pigmentation (HP:0008002)	1.93238537
76	Stomach cancer (HP:0012126)	1.92391844
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88701585
78	Retinal dysplasia (HP:0007973)	1.87840927
79	Bifid tongue (HP:0010297)	1.86632261
80	Abnormality of alanine metabolism (HP:0010916)	1.85632025
81	Hyperalaninemia (HP:0003348)	1.85632025
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85632025
83	Protruding tongue (HP:0010808)	1.85376771
84	Glioma (HP:0009733)	1.83969771
85	Polydipsia (HP:0001959)	1.83390977
86	Abnormal drinking behavior (HP:0030082)	1.83390977
87	Hypoplastic iliac wings (HP:0002866)	1.83272298
88	Meckel diverticulum (HP:0002245)	1.82238705
89	Mitochondrial inheritance (HP:0001427)	1.81908946
90	Hepatic necrosis (HP:0002605)	1.80638390
91	Impulsivity (HP:0100710)	1.80343647
92	Type I transferrin isoform profile (HP:0003642)	1.80090085
93	Hemiparesis (HP:0001269)	1.79953247
94	Ectopic kidney (HP:0000086)	1.78649637
95	Increased corneal curvature (HP:0100692)	1.76615283
96	Keratoconus (HP:0000563)	1.76615283
97	Aganglionic megacolon (HP:0002251)	1.76548930
98	Postaxial hand polydactyly (HP:0001162)	1.76430449
99	Neonatal respiratory distress (HP:0002643)	1.76325144
100	Albinism (HP:0001022)	1.74028510

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.02365736
2	BMPR1B	4.83451987
3	ACVR1B	2.98086573
4	NUAK1	2.61888810
5	TRIM28	2.15991486
6	INSRR	2.09741015
7	MAP4K2	2.08166828
8	PINK1	2.02834997
9	WNK4	1.94472001
10	PDK2	1.84503582
11	WNK3	1.82900203
12	TGFBR1	1.79009461
13	TAOK3	1.74424113
14	CDK8	1.68759880
15	MKNK2	1.48627137
16	MST4	1.44125230
17	PLK4	1.41894015
18	GRK1	1.37947900
19	FGFR2	1.37707852
20	ADRBK2	1.36281513
21	MAPK13	1.34174090
22	VRK1	1.28879042
23	STK39	1.28462320
24	PIK3CA	1.27463686
25	OXSR1	1.21314104
26	TEC	1.19427633
27	ZAK	1.18940510
28	TNIK	1.14114402
29	EIF2AK3	1.13437752
30	BRD4	1.12147796
31	KIT	1.09696638
32	TXK	1.08543274
33	AKT3	1.05461026
34	STK38L	1.03100769
35	CSNK1A1L	1.02224523
36	TNK2	0.99510242
37	PLK2	0.96702000
38	CDK12	0.94078626
39	PAK3	0.88113887
40	ATR	0.85858698
41	MKNK1	0.84940151
42	IRAK1	0.83761323
43	FLT3	0.82605279
44	MARK3	0.81530292
45	BCR	0.80511295
46	CSNK1G1	0.79402335
47	BRSK2	0.76735275
48	CASK	0.76728705
49	BLK	0.76361547
50	EPHA3	0.74984250
51	MAP3K4	0.74336211
52	ADRBK1	0.74333002
53	CDK3	0.73861144
54	RPS6KA4	0.72412897
55	CSNK1G3	0.71024455
56	ITK	0.68089051
57	SRPK1	0.67234808
58	PRKCE	0.65910077
59	PLK3	0.65748035
60	CAMK1D	0.65429908
61	NLK	0.64885741
62	CDK9	0.64847164
63	CAMKK2	0.64302244
64	LATS1	0.63943241
65	TLK1	0.62759124
66	ATM	0.61517112
67	ERBB3	0.61145938
68	RPS6KA5	0.61107705
69	CSNK1G2	0.61013086
70	STK38	0.60770938
71	EIF2AK1	0.58112048
72	PTK2B	0.57811103
73	BCKDK	0.56352623
74	IKBKB	0.55729788
75	PRKCQ	0.53813432
76	SYK	0.52840092
77	FER	0.51574401
78	CSNK1A1	0.48562099
79	MAPK11	0.45988550
80	WNK1	0.45071916
81	CAMK1G	0.44707437
82	MAP4K1	0.43665967
83	MAPK15	0.43450914
84	VRK2	0.43317635
85	CHUK	0.41301434
86	CDC7	0.40769094
87	LCK	0.39432621
88	DYRK3	0.38406855
89	LYN	0.37566756
90	GRK6	0.37113696
91	CSNK1D	0.35342661
92	MAPKAPK3	0.35067080
93	TIE1	0.35037886
94	ERBB2	0.35034543
95	PKN1	0.34329772
96	MAPK1	0.31842610
97	TRPM7	0.31770029
98	BMPR2	0.31753582
99	PIK3CG	0.31489064
100	FES	0.30251285

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	5.04755970
2	Homologous recombination_Homo sapiens_hsa03440	3.30392337
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.09540812
4	Phototransduction_Homo sapiens_hsa04744	2.78600255
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.77920274
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52158244
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39647012
8	RNA polymerase_Homo sapiens_hsa03020	2.37478591
9	Basal transcription factors_Homo sapiens_hsa03022	2.30246950
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.19633054
11	Butanoate metabolism_Homo sapiens_hsa00650	2.04801485
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87576177
13	Olfactory transduction_Homo sapiens_hsa04740	1.78456944
14	RNA degradation_Homo sapiens_hsa03018	1.77158712
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73861191
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71081353
17	Lysine degradation_Homo sapiens_hsa00310	1.66513657
18	Propanoate metabolism_Homo sapiens_hsa00640	1.62646286
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.60620091
20	Protein export_Homo sapiens_hsa03060	1.56201340
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54068208
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44738118
23	Taste transduction_Homo sapiens_hsa04742	1.44056484
24	One carbon pool by folate_Homo sapiens_hsa00670	1.42513921
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42315826
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.39495177
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.35249850
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33003719
29	Mismatch repair_Homo sapiens_hsa03430	1.25671061
30	Peroxisome_Homo sapiens_hsa04146	1.21470412
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20008129
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.11736909
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.09741924
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.08526231
35	* Oocyte meiosis_Homo sapiens_hsa04114	1.06977042
36	Asthma_Homo sapiens_hsa05310	1.03352223
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03342403
38	ABC transporters_Homo sapiens_hsa02010	1.02953900
39	Purine metabolism_Homo sapiens_hsa00230	1.01458517
40	Nicotine addiction_Homo sapiens_hsa05033	1.00950145
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98690323
42	RNA transport_Homo sapiens_hsa03013	0.97881893
43	* Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.95407975
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94925308
45	Proteasome_Homo sapiens_hsa03050	0.94163973
46	Regulation of autophagy_Homo sapiens_hsa04140	0.91244487
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.89235867
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87263812
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84802769
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82802031
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81462468
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.80308954
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74698095
54	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.74470955
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72655682
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.72524807
57	Salivary secretion_Homo sapiens_hsa04970	0.72435117
58	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72010454
59	Oxidative phosphorylation_Homo sapiens_hsa00190	0.71981392
60	Base excision repair_Homo sapiens_hsa03410	0.70908087
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.70620414
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70592620
63	Circadian rhythm_Homo sapiens_hsa04710	0.68987119
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67155503
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63828273
66	Huntingtons disease_Homo sapiens_hsa05016	0.62202407
67	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61870927
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61746610
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61025445
70	Metabolic pathways_Homo sapiens_hsa01100	0.59036857
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.58556480
72	Insulin secretion_Homo sapiens_hsa04911	0.58533418
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57860515
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55358767
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53583196
76	Fatty acid elongation_Homo sapiens_hsa00062	0.52872720
77	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52031526
78	Allograft rejection_Homo sapiens_hsa05330	0.51559035
79	Parkinsons disease_Homo sapiens_hsa05012	0.50719256
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50604560
81	Retinol metabolism_Homo sapiens_hsa00830	0.50057259
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49455891
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49215091
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45061153
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42033721
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41312172
87	Amphetamine addiction_Homo sapiens_hsa05031	0.39874637
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38867137
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38738260
90	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37564885
91	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36668022
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35428885
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34685126
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34614845
95	Circadian entrainment_Homo sapiens_hsa04713	0.34202012
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33463488
97	Fatty acid degradation_Homo sapiens_hsa00071	0.31249054
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28915873
99	DNA replication_Homo sapiens_hsa03030	0.27639027
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.26005252

SPDYE5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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