SPDYE6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.51223306
2histone H3-K4 methylation (GO:0051568)5.07243035
3establishment of protein localization to Golgi (GO:0072600)4.59484641
4regulation of ARF GTPase activity (GO:0032312)4.45260434
5positive regulation of granulocyte differentiation (GO:0030854)4.36824791
6retrograde transport, vesicle recycling within Golgi (GO:0000301)4.36779109
7histone H3-K36 demethylation (GO:0070544)4.33977416
8peptidyl-lysine trimethylation (GO:0018023)4.22204096
9protein targeting to Golgi (GO:0000042)4.18076394
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.14491119
11negative regulation of translation, ncRNA-mediated (GO:0040033)4.14491119
12regulation of translation, ncRNA-mediated (GO:0045974)4.14491119
13cellular response to ethanol (GO:0071361)3.98210702
14DNA double-strand break processing (GO:0000729)3.95941112
15histone lysine methylation (GO:0034968)3.88385301
16regulation of MHC class I biosynthetic process (GO:0045343)3.79366042
17N-terminal protein amino acid acetylation (GO:0006474)3.62442037
18maintenance of gastrointestinal epithelium (GO:0030277)3.58886888
19regulation of histone H3-K4 methylation (GO:0051569)3.54530732
20pre-miRNA processing (GO:0031054)3.52365166
21monoubiquitinated protein deubiquitination (GO:0035520)3.51798688
22regulation of B cell receptor signaling pathway (GO:0050855)3.42758925
23TOR signaling (GO:0031929)3.38580184
24positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.32887529
25regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.32887529
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31213737
27mannose metabolic process (GO:0006013)3.31034997
28regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.28564252
29positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.28564252
30histone H3-K9 methylation (GO:0051567)3.28056735
31cytoplasmic mRNA processing body assembly (GO:0033962)3.25586214
32histone H3-K9 modification (GO:0061647)3.23996589
33positive regulation of gamma-delta T cell activation (GO:0046645)3.23496159
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.23218944
35peptidyl-lysine methylation (GO:0018022)3.18705245
36muscle atrophy (GO:0014889)3.18665585
37negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.16180504
38regulation of mRNA catabolic process (GO:0061013)3.15138525
39striated muscle atrophy (GO:0014891)3.12436403
40regulation of DNA endoreduplication (GO:0032875)3.12303172
41regulation of granulocyte differentiation (GO:0030852)3.09940549
42regulation of histone H3-K27 methylation (GO:0061085)3.03946134
43positive regulation of mRNA catabolic process (GO:0061014)3.03798804
44negative regulation of cell cycle G2/M phase transition (GO:1902750)3.02265647
45histone lysine demethylation (GO:0070076)2.99369830
46histone methylation (GO:0016571)2.94227054
47positive regulation by host of viral transcription (GO:0043923)2.92364528
48positive regulation of CREB transcription factor activity (GO:0032793)2.92134461
49histone demethylation (GO:0016577)2.92085123
50protein K48-linked deubiquitination (GO:0071108)2.91056521
51T-helper cell differentiation (GO:0042093)2.90469139
52CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.90469139
53skeletal muscle adaptation (GO:0043501)2.89711889
54cellular response to exogenous dsRNA (GO:0071360)2.88466381
55hepatocyte apoptotic process (GO:0097284)2.86708308
56epithelial structure maintenance (GO:0010669)2.85939863
57auditory receptor cell differentiation (GO:0042491)2.85297061
58histone deubiquitination (GO:0016578)2.79136204
59histone H3-K9 demethylation (GO:0033169)2.77788805
60response to muramyl dipeptide (GO:0032495)2.75180475
61double-strand break repair via homologous recombination (GO:0000724)2.74816166
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.74594692
63protein localization to Golgi apparatus (GO:0034067)2.73721999
64mRNA cleavage (GO:0006379)2.72688221
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.70116536
66modulation by symbiont of host immune response (GO:0052553)2.70116536
67positive regulation by symbiont of host defense response (GO:0052509)2.70116536
68modulation by symbiont of host defense response (GO:0052031)2.70116536
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70116536
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70116536
71regulation of histone methylation (GO:0031060)2.68331089
72regulation of gamma-delta T cell activation (GO:0046643)2.67787371
73protein dealkylation (GO:0008214)2.66970229
74protein demethylation (GO:0006482)2.66970229
75V(D)J recombination (GO:0033151)2.66182609
76recombinational repair (GO:0000725)2.64525409
77fibroblast migration (GO:0010761)2.64452348
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61751605
79receptor catabolic process (GO:0032801)2.61284580
80mitochondrial DNA replication (GO:0006264)2.59941735
81coronary vasculature morphogenesis (GO:0060977)2.57311764
82regulation of hippo signaling (GO:0035330)2.56327134
83positive regulation of developmental pigmentation (GO:0048087)2.55109066
84negative regulation of macroautophagy (GO:0016242)2.52468178
85alpha-beta T cell differentiation (GO:0046632)2.52075189
86interkinetic nuclear migration (GO:0022027)2.51426155
87rRNA catabolic process (GO:0016075)2.51112301
88cellular extravasation (GO:0045123)2.50623604
89intra-Golgi vesicle-mediated transport (GO:0006891)2.49191756
90histone mRNA catabolic process (GO:0071044)2.48644538
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47519095
92regulation of gamma-delta T cell differentiation (GO:0045586)2.47079033
93corticosteroid receptor signaling pathway (GO:0031958)2.46552409
94snRNA transcription (GO:0009301)2.46320986
95protein K63-linked deubiquitination (GO:0070536)2.45121218
96negative T cell selection (GO:0043383)2.43200270
97definitive hemopoiesis (GO:0060216)2.42832594
98glucocorticoid receptor signaling pathway (GO:0042921)2.42450253
99negative thymic T cell selection (GO:0045060)2.42256569
100nuclear pore complex assembly (GO:0051292)2.41096724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77232928
2GATA1_22025678_ChIP-Seq_K562_Human3.75338911
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70126616
4E2F7_22180533_ChIP-Seq_HELA_Human3.58123392
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04544048
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91588723
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79862373
8SCL_19346495_ChIP-Seq_HPC-7_Human2.54062231
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53868834
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.52820241
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.52367055
12SPI1_23127762_ChIP-Seq_K562_Human2.34652602
13RUNX_20019798_ChIP-Seq_JUKART_Human2.32470162
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.26584579
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.20118782
16ER_23166858_ChIP-Seq_MCF-7_Human2.04480417
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02561075
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.00812378
19MYC_22102868_ChIP-Seq_BL_Human1.95450720
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91969178
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87932441
22* MYB_26560356_Chip-Seq_TH2_Human1.87562735
23MYB_26560356_Chip-Seq_TH1_Human1.84598687
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.78066663
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70270264
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65790422
27GATA3_27048872_Chip-Seq_THYMUS_Human1.65523179
28AR_21572438_ChIP-Seq_LNCaP_Human1.61364542
29TP53_16413492_ChIP-PET_HCT116_Human1.58400219
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.58037019
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51893725
32AHR_22903824_ChIP-Seq_MCF-7_Human1.51349253
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50556557
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49192697
35CIITA_25753668_ChIP-Seq_RAJI_Human1.47488496
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.47123906
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46888460
38GATA3_26560356_Chip-Seq_TH2_Human1.45979160
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45858072
40CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45587178
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45409388
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44158945
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40766603
44VDR_24787735_ChIP-Seq_THP-1_Human1.38698083
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.37330980
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37096851
47VDR_21846776_ChIP-Seq_THP-1_Human1.36721575
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.35939754
49DROSHA_22980978_ChIP-Seq_HELA_Human1.35334911
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.33867298
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33131702
52MAF_26560356_Chip-Seq_TH2_Human1.32921177
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32525574
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.30059156
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28423976
56VDR_24763502_ChIP-Seq_THP-1_Human1.28004516
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27061401
58TCF7_22412390_ChIP-Seq_EML_Mouse1.26409048
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25800928
60UTX_26944678_Chip-Seq_JUKART_Human1.25347028
61MAF_26560356_Chip-Seq_TH1_Human1.24792985
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.24179838
63SPI1_23547873_ChIP-Seq_NB4_Human1.23790356
64GATA1_19941826_ChIP-Seq_K562_Human1.23123518
65IGF1R_20145208_ChIP-Seq_DFB_Human1.22654043
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21697759
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20224246
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19452676
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.18496391
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.17536040
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17096841
72GATA2_19941826_ChIP-Seq_K562_Human1.15895937
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12482011
74STAT3_23295773_ChIP-Seq_U87_Human1.12065214
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.12041412
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08253741
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.06705970
78KDM2B_26808549_Chip-Seq_DND41_Human1.05419242
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04924772
80ZNF274_21170338_ChIP-Seq_K562_Hela1.04901142
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03789152
82GATA6_25053715_ChIP-Seq_YYC3_Human1.02468755
83SMRT_27268052_Chip-Seq_Bcells_Human1.01978718
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.00722119
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99543845
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99159122
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98299622
88RUNX1_22412390_ChIP-Seq_EML_Mouse0.98083123
89BP1_19119308_ChIP-ChIP_Hs578T_Human0.95404052
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95217981
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.94904474
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94774481
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92927310
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92927310
95TCF4_23295773_ChIP-Seq_U87_Human0.92371224
96BCAT_22108803_ChIP-Seq_LS180_Human0.92141415
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92130790
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.90442080
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89027565
100VDR_22108803_ChIP-Seq_LS180_Human0.88446800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.88420288
2MP0000569_abnormal_digit_pigmentation3.57470557
3MP0003763_abnormal_thymus_physiology3.34255052
4MP0004381_abnormal_hair_follicle2.68665450
5MP0002396_abnormal_hematopoietic_system2.65992703
6MP0010094_abnormal_chromosome_stability2.58024501
7MP0000465_gastrointestinal_hemorrhage2.50210896
8MP0002009_preneoplasia2.41330723
9MP0000015_abnormal_ear_pigmentation2.24923092
10MP0004808_abnormal_hematopoietic_stem2.18303142
11MP0005076_abnormal_cell_differentiation2.16068235
12MP0000372_irregular_coat_pigmentation2.05089010
13MP0004233_abnormal_muscle_weight2.03694480
14MP0005174_abnormal_tail_pigmentation1.97348756
15MP0003045_fibrosis1.95338200
16MP0001800_abnormal_humoral_immune1.85379342
17MP0005310_abnormal_salivary_gland1.84707981
18MP0004043_abnormal_pH_regulation1.78931659
19MP0000703_abnormal_thymus_morphology1.77443384
20MP0001835_abnormal_antigen_presentation1.71139414
21MP0003646_muscle_fatigue1.61041142
22MP0003172_abnormal_lysosome_physiology1.60986474
23MP0000371_diluted_coat_color1.59830328
24MP0008004_abnormal_stomach_pH1.57130249
25MP0005171_absent_coat_pigmentation1.56487859
26MP0002398_abnormal_bone_marrow1.55539367
27MP0002168_other_aberrant_phenotype1.51081403
28MP0005451_abnormal_body_composition1.50344550
29MP0002405_respiratory_system_inflammati1.43706726
30MP0008961_abnormal_basal_metabolism1.43242887
31MP0000749_muscle_degeneration1.40472491
32MP0003111_abnormal_nucleus_morphology1.39891137
33MP0002452_abnormal_antigen_presenting1.39287900
34MP0002723_abnormal_immune_serum1.37196557
35MP0002722_abnormal_immune_system1.36834753
36MP0008995_early_reproductive_senescence1.34932442
37MP0001819_abnormal_immune_cell1.34575380
38MP0002420_abnormal_adaptive_immunity1.34249189
39MP0005075_abnormal_melanosome_morpholog1.32588847
40MP0001873_stomach_inflammation1.32537739
41MP0000689_abnormal_spleen_morphology1.32480231
42MP0004264_abnormal_extraembryonic_tissu1.32007922
43MP0005397_hematopoietic_system_phenotyp1.31834580
44MP0001545_abnormal_hematopoietic_system1.31834580
45MP0009278_abnormal_bone_marrow1.31656157
46MP0002166_altered_tumor_susceptibility1.31099087
47MP0001790_abnormal_immune_system1.31020088
48MP0005387_immune_system_phenotype1.31020088
49MP0000716_abnormal_immune_system1.27777046
50MP0005408_hypopigmentation1.26945010
51MP0003866_abnormal_defecation1.26785983
52MP0010307_abnormal_tumor_latency1.21150704
53MP0005409_darkened_coat_color1.20485032
54MP0003656_abnormal_erythrocyte_physiolo1.18630851
55MP0003436_decreased_susceptibility_to1.17896448
56MP0002095_abnormal_skin_pigmentation1.17829013
57MP0002138_abnormal_hepatobiliary_system1.17773307
58MP0002419_abnormal_innate_immunity1.17298611
59MP0000427_abnormal_hair_cycle1.16039187
60MP0003077_abnormal_cell_cycle1.13864700
61MP0000383_abnormal_hair_follicle1.13051828
62MP0005000_abnormal_immune_tolerance1.12251626
63MP0001270_distended_abdomen1.09298642
64MP0003091_abnormal_cell_migration1.06552032
65MP0003195_calcinosis1.06281734
66MP0005025_abnormal_response_to1.05792294
67MP0004134_abnormal_chest_morphology1.05673155
68MP0002132_abnormal_respiratory_system1.05615863
69MP0002429_abnormal_blood_cell1.03193616
70MP0008058_abnormal_DNA_repair1.02942060
71MP0010155_abnormal_intestine_physiology1.02418496
72MP0009697_abnormal_copulation0.99711005
73MP0003300_gastrointestinal_ulcer0.99505285
74MP0002098_abnormal_vibrissa_morphology0.96616516
75MP0002075_abnormal_coat/hair_pigmentati0.95615267
76MP0002928_abnormal_bile_duct0.93126583
77MP0003786_premature_aging0.92337221
78MP0005083_abnormal_biliary_tract0.90400360
79MP0001661_extended_life_span0.86871747
80MP0009115_abnormal_fat_cell0.86112740
81MP0002970_abnormal_white_adipose0.82798468
82MP0002127_abnormal_cardiovascular_syste0.82365620
83MP0000470_abnormal_stomach_morphology0.81409285
84MP0005671_abnormal_response_to0.80162608
85MP0002019_abnormal_tumor_incidence0.79205331
86MP0005621_abnormal_cell_physiology0.78553791
87MP0000685_abnormal_immune_system0.77557700
88MP0005395_other_phenotype0.77397029
89MP0005058_abnormal_lysosome_morphology0.76955122
90MP0003252_abnormal_bile_duct0.75068117
91MP0003828_pulmonary_edema0.73503934
92MP0003984_embryonic_growth_retardation0.72695757
93MP0010678_abnormal_skin_adnexa0.71400408
94MP0000733_abnormal_muscle_development0.70359730
95MP0001845_abnormal_inflammatory_respons0.69911311
96MP0003943_abnormal_hepatobiliary_system0.69890155
97MP0002108_abnormal_muscle_morphology0.69635783
98MP0003705_abnormal_hypodermis_morpholog0.68026355
99MP0004947_skin_inflammation0.67685711
100MP0002088_abnormal_embryonic_growth/wei0.67213891

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.10892466
2Abnormality of the columella (HP:0009929)4.41510200
3Genetic anticipation (HP:0003743)3.75362228
4Ectopic kidney (HP:0000086)3.27834619
5Long eyelashes (HP:0000527)3.27193518
6Obstructive sleep apnea (HP:0002870)3.27105003
7Chromsome breakage (HP:0040012)3.17327703
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16099704
9Narrow palate (HP:0000189)3.04144465
10Colitis (HP:0002583)2.98796553
11Prominent nose (HP:0000448)2.96157365
12Abnormality of chromosome stability (HP:0003220)2.86922863
13Abnormal delayed hypersensitivity skin test (HP:0002963)2.84335635
14Spondylolisthesis (HP:0003302)2.84202767
15Hypoplastic iliac wings (HP:0002866)2.81927426
16Panhypogammaglobulinemia (HP:0003139)2.76237088
17Protruding tongue (HP:0010808)2.74362251
18Urethral obstruction (HP:0000796)2.68627082
19Clumsiness (HP:0002312)2.67838696
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.62651057
21Tented upper lip vermilion (HP:0010804)2.61908450
22Clubbing of toes (HP:0100760)2.61689718
23Tubulointerstitial nephritis (HP:0001970)2.58545063
24Heterotopia (HP:0002282)2.56787177
25Self-mutilation (HP:0000742)2.53820564
26Recurrent cutaneous fungal infections (HP:0011370)2.50210545
27Chronic mucocutaneous candidiasis (HP:0002728)2.50210545
28Broad face (HP:0000283)2.47965168
29Truncal obesity (HP:0001956)2.45255140
30Hypoplastic ischia (HP:0003175)2.43969979
31Abnormality of DNA repair (HP:0003254)2.43362311
32Abnormal hair whorl (HP:0010721)2.40769212
33Recurrent fungal infections (HP:0002841)2.40349723
34Lip pit (HP:0100267)2.39213448
35Abnormality of the preputium (HP:0100587)2.37664033
36Abnormality of the nasal septum (HP:0000419)2.35982229
37Inflammation of the large intestine (HP:0002037)2.31585767
38Progressive cerebellar ataxia (HP:0002073)2.28883576
39Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.28163714
40Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.23970538
41Gastrointestinal inflammation (HP:0004386)2.21735027
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17182554
43Submucous cleft hard palate (HP:0000176)2.15211971
44Abnormality of the incisor (HP:0000676)2.13764972
45Sparse lateral eyebrow (HP:0005338)2.12999284
46Low anterior hairline (HP:0000294)2.12929222
47Long clavicles (HP:0000890)2.12557446
48Severe combined immunodeficiency (HP:0004430)2.11876160
49Recurrent viral infections (HP:0004429)2.11566966
50Abnormality of the sella turcica (HP:0002679)2.11455695
51Cafe-au-lait spot (HP:0000957)2.11400574
52Thick eyebrow (HP:0000574)2.10233555
53Abnormality of the ileum (HP:0001549)2.07166671
54Depressed nasal tip (HP:0000437)2.05905476
55Albinism (HP:0001022)2.03065000
56Sloping forehead (HP:0000340)2.01875680
57High anterior hairline (HP:0009890)2.00956199
58Acute lymphatic leukemia (HP:0006721)2.00592301
59Hypopigmentation of the fundus (HP:0007894)1.99812994
60Granulocytopenia (HP:0001913)1.99281689
61Thoracic kyphosis (HP:0002942)1.98009061
62T lymphocytopenia (HP:0005403)1.97185050
63Hypoplasia of the thymus (HP:0000778)1.97004213
64Meckel diverticulum (HP:0002245)1.96268367
65Increased number of teeth (HP:0011069)1.90778591
66Duplicated collecting system (HP:0000081)1.89354143
67Gaze-evoked nystagmus (HP:0000640)1.89222753
68Hyperkalemia (HP:0002153)1.88747839
69Slow saccadic eye movements (HP:0000514)1.88737792
70Chronic hepatic failure (HP:0100626)1.87724074
71Prolonged bleeding time (HP:0003010)1.86336905
72Abnormality of lateral ventricle (HP:0030047)1.84857445
73Ependymoma (HP:0002888)1.84155476
74Abnormality of the epiphyses of the hand (HP:0005924)1.82263484
75Eosinophilia (HP:0001880)1.81893664
76Ocular albinism (HP:0001107)1.79672155
77Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.78304261
78Abnormality of the wing of the ilium (HP:0011867)1.77500788
79Cerebral aneurysm (HP:0004944)1.76847649
80Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.76402682
81Abnormality of the frontal sinuses (HP:0002687)1.76226855
82Abnormality of eosinophils (HP:0001879)1.75288366
83Sandal gap (HP:0001852)1.74902056
84Abnormality of the ischium (HP:0003174)1.73890984
85Volvulus (HP:0002580)1.72081870
86Leukopenia (HP:0001882)1.71082152
87Abnormality of chromosome segregation (HP:0002916)1.70027803
88Mask-like facies (HP:0000298)1.69600728
89Impulsivity (HP:0100710)1.69526852
90Smooth philtrum (HP:0000319)1.68166710
91Acute myeloid leukemia (HP:0004808)1.68105072
92Abnormality of the thoracic spine (HP:0100711)1.67779277
93Abnormality of T cell number (HP:0011839)1.64833780
94Fatigue (HP:0012378)1.63818709
95Abnormality of incisor morphology (HP:0011063)1.62877876
96Tapered finger (HP:0001182)1.62849236
97Spinal muscular atrophy (HP:0007269)1.61259584
98High pitched voice (HP:0001620)1.60539002
99Duodenal stenosis (HP:0100867)1.58167175
100Small intestinal stenosis (HP:0012848)1.58167175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.29732659
2FRK3.38746080
3BLK2.66969268
4CAMK1G2.61931636
5MST1R2.55342753
6CAMK1D2.51458659
7MARK32.46336261
8BRD42.33291737
9NLK2.06366353
10WNK42.00786493
11ICK1.92756563
12NME11.71348210
13MAP4K11.63200898
14TRIB31.58210932
15CDC42BPA1.58158651
16MAP3K141.55798088
17ACVR1B1.53969058
18AKT31.53030567
19TNK21.52115120
20BMPR1B1.46463084
21GRK61.41457977
22MELK1.32291575
23WNK11.27289803
24MAP3K71.23122117
25SIK31.20537412
26PNCK1.19226234
27MTOR1.17856036
28MAP3K131.16276918
29PKN21.15951694
30NEK21.10544979
31MAPK111.10183785
32FGFR21.09885444
33MAP3K101.08439238
34STK391.07485347
35MARK21.05550512
36INSRR1.03176812
37PDK21.01942110
38PTK2B1.01634434
39BTK0.99287702
40EIF2AK30.98751924
41FES0.98711178
42MAP2K30.98560098
43FGFR30.98367588
44TAOK30.95562697
45CHUK0.94293077
46TYK20.91277140
47IKBKE0.90892354
48PRKAA20.90380778
49TXK0.90148690
50WNK30.89695013
51SGK20.87352776
52CDK80.87277077
53RIPK40.86993532
54SIK20.86841266
55JAK10.83462163
56TEC0.82724187
57ZAP700.81197852
58MKNK20.79409380
59IRAK40.79095857
60ERN10.78820030
61TRPM70.78586148
62IKBKB0.78104427
63ATR0.77925577
64HCK0.77154586
65FGFR40.77081162
66OBSCN0.74548769
67CAMK40.74285672
68PINK10.70913404
69CHEK10.70606886
70CDK40.67949052
71SYK0.65484739
72CDK90.62690563
73TNIK0.59308601
74PAK30.58743158
75MET0.58570173
76SGK30.57825672
77FGR0.57436951
78TAOK10.55303948
79ITK0.54998552
80NUAK10.52558306
81ATM0.52362068
82STK40.51370747
83LATS10.51088581
84STK380.48880012
85MAPK150.48203845
86PRKAA10.47934948
87MAPK10.47270540
88PIK3CG0.47063928
89CHEK20.46791601
90HIPK20.45460938
91TRIM280.44256343
92PDGFRB0.42706480
93MAP3K30.42538785
94BRSK20.42442648
95LYN0.41177860
96TBK10.40480850
97EEF2K0.39230713
98IRAK10.39006447
99WEE10.38357893
100PIM10.37947475

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.73380026
2Fanconi anemia pathway_Homo sapiens_hsa034602.38137759
3* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.16799211
4Other glycan degradation_Homo sapiens_hsa005111.99866480
5Phosphatidylinositol signaling system_Homo sapiens_hsa040701.87980322
6Acute myeloid leukemia_Homo sapiens_hsa052211.87401477
7Non-homologous end-joining_Homo sapiens_hsa034501.86018130
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.85267404
9Dorso-ventral axis formation_Homo sapiens_hsa043201.65212100
10Prostate cancer_Homo sapiens_hsa052151.62859918
11Primary immunodeficiency_Homo sapiens_hsa053401.61549960
12B cell receptor signaling pathway_Homo sapiens_hsa046621.60217057
13Inositol phosphate metabolism_Homo sapiens_hsa005621.59309005
14Osteoclast differentiation_Homo sapiens_hsa043801.54958802
15Notch signaling pathway_Homo sapiens_hsa043301.54878086
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53897475
17T cell receptor signaling pathway_Homo sapiens_hsa046601.46956474
18Measles_Homo sapiens_hsa051621.45975431
19Homologous recombination_Homo sapiens_hsa034401.44084478
20Hepatitis B_Homo sapiens_hsa051611.41343900
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37667043
22FoxO signaling pathway_Homo sapiens_hsa040681.35974304
23Non-small cell lung cancer_Homo sapiens_hsa052231.35456164
24Herpes simplex infection_Homo sapiens_hsa051681.33379920
25Choline metabolism in cancer_Homo sapiens_hsa052311.27046344
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24893162
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22591064
28ABC transporters_Homo sapiens_hsa020101.20186218
29TNF signaling pathway_Homo sapiens_hsa046681.15443444
30mTOR signaling pathway_Homo sapiens_hsa041501.15135836
31Chronic myeloid leukemia_Homo sapiens_hsa052201.15068329
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.13406683
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09098171
34Influenza A_Homo sapiens_hsa051641.08989711
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03242502
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02532933
37MicroRNAs in cancer_Homo sapiens_hsa052061.02194233
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01668781
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01430875
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00738794
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99722692
42RNA polymerase_Homo sapiens_hsa030200.98925746
43Endometrial cancer_Homo sapiens_hsa052130.98757895
44Insulin resistance_Homo sapiens_hsa049310.98608228
45Platelet activation_Homo sapiens_hsa046110.94504954
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93915386
47* Oocyte meiosis_Homo sapiens_hsa041140.92759385
48Pancreatic cancer_Homo sapiens_hsa052120.88099007
49Epstein-Barr virus infection_Homo sapiens_hsa051690.87426209
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.86972574
51Basal transcription factors_Homo sapiens_hsa030220.86332928
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84624995
53Tuberculosis_Homo sapiens_hsa051520.83311868
54Hepatitis C_Homo sapiens_hsa051600.82301269
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81752556
56Apoptosis_Homo sapiens_hsa042100.81378138
57mRNA surveillance pathway_Homo sapiens_hsa030150.80456007
58Type II diabetes mellitus_Homo sapiens_hsa049300.79713184
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78790037
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77983118
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77549517
62Colorectal cancer_Homo sapiens_hsa052100.76798341
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76332968
64Leishmaniasis_Homo sapiens_hsa051400.75619731
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.75573803
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.75206466
67Olfactory transduction_Homo sapiens_hsa047400.74833634
68DNA replication_Homo sapiens_hsa030300.74527708
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.74089007
70Glucagon signaling pathway_Homo sapiens_hsa049220.73644312
71Viral carcinogenesis_Homo sapiens_hsa052030.71515770
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70688269
73Cell cycle_Homo sapiens_hsa041100.69916422
74Malaria_Homo sapiens_hsa051440.69403399
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67153026
76Calcium signaling pathway_Homo sapiens_hsa040200.67006110
77GnRH signaling pathway_Homo sapiens_hsa049120.66804524
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66405960
79Estrogen signaling pathway_Homo sapiens_hsa049150.65120944
80Small cell lung cancer_Homo sapiens_hsa052220.65118117
81p53 signaling pathway_Homo sapiens_hsa041150.64015952
82Toxoplasmosis_Homo sapiens_hsa051450.63323616
83Staphylococcus aureus infection_Homo sapiens_hsa051500.62770562
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61768463
85Glioma_Homo sapiens_hsa052140.59985170
86Renal cell carcinoma_Homo sapiens_hsa052110.58928429
87Glycerolipid metabolism_Homo sapiens_hsa005610.55538945
88Prolactin signaling pathway_Homo sapiens_hsa049170.55368249
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54496077
90VEGF signaling pathway_Homo sapiens_hsa043700.53812132
91Thyroid cancer_Homo sapiens_hsa052160.53150576
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.52126731
93Hematopoietic cell lineage_Homo sapiens_hsa046400.51758588
94Insulin signaling pathway_Homo sapiens_hsa049100.51476349
95HTLV-I infection_Homo sapiens_hsa051660.51471525
96African trypanosomiasis_Homo sapiens_hsa051430.51057746
97RNA degradation_Homo sapiens_hsa030180.50936981
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50268526
99Adherens junction_Homo sapiens_hsa045200.50026386
100HIF-1 signaling pathway_Homo sapiens_hsa040660.49871665

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