ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to misfolded protein (GO:0051788)	6.50413167
2	response to pheromone (GO:0019236)	5.18093756
3	dendritic spine morphogenesis (GO:0060997)	5.15204103
4	superoxide anion generation (GO:0042554)	4.89596865
5	retinal rod cell development (GO:0046548)	4.78207978
6	protein polyglutamylation (GO:0018095)	4.66176142
7	photoreceptor cell maintenance (GO:0045494)	4.43472615
8	nonmotile primary cilium assembly (GO:0035058)	4.37217136
9	regulation of cilium movement (GO:0003352)	3.86644963
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82272311
11	termination of RNA polymerase III transcription (GO:0006386)	3.66925625
12	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.66925625
13	indolalkylamine metabolic process (GO:0006586)	3.64158746
14	behavioral response to nicotine (GO:0035095)	3.61384837
15	lysine metabolic process (GO:0006553)	3.61247733
16	lysine catabolic process (GO:0006554)	3.61247733
17	regulation of helicase activity (GO:0051095)	3.57344017
18	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.56641482
19	reciprocal DNA recombination (GO:0035825)	3.52291812
20	reciprocal meiotic recombination (GO:0007131)	3.52291812
21	ubiquinone metabolic process (GO:0006743)	3.43765864
22	inner ear receptor stereocilium organization (GO:0060122)	3.40927274
23	GTP biosynthetic process (GO:0006183)	3.39429937
24	ubiquinone biosynthetic process (GO:0006744)	3.38714321
25	negative regulation of appetite (GO:0032099)	3.38623580
26	negative regulation of response to food (GO:0032096)	3.38623580
27	ribosomal small subunit assembly (GO:0000028)	3.31953722
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31437963
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31437963
30	auditory receptor cell stereocilium organization (GO:0060088)	3.30816089
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.29847758
32	pyrimidine nucleobase catabolic process (GO:0006208)	3.20942024
33	cilium morphogenesis (GO:0060271)	3.19809434
34	protein neddylation (GO:0045116)	3.15752437
35	protein-cofactor linkage (GO:0018065)	3.15747279
36	epithelial cilium movement (GO:0003351)	3.13598163
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.13415433
38	dendritic spine organization (GO:0097061)	3.10231340
39	photoreceptor cell development (GO:0042461)	3.09730146
40	transmission of nerve impulse (GO:0019226)	3.08082683
41	platelet dense granule organization (GO:0060155)	3.05492787
42	intraciliary transport (GO:0042073)	3.01242958
43	mismatch repair (GO:0006298)	2.98420011
44	UTP biosynthetic process (GO:0006228)	2.96724278
45	presynaptic membrane assembly (GO:0097105)	2.96038994
46	aspartate family amino acid catabolic process (GO:0009068)	2.95490994
47	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.93510765
48	neuron cell-cell adhesion (GO:0007158)	2.91896092
49	protein complex biogenesis (GO:0070271)	2.91048813
50	regulation of respiratory system process (GO:0044065)	2.90855824
51	ATP synthesis coupled proton transport (GO:0015986)	2.90840180
52	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.90840180
53	mannosylation (GO:0097502)	2.90153227
54	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.89339556
55	axoneme assembly (GO:0035082)	2.87935541
56	anterograde synaptic vesicle transport (GO:0048490)	2.87822714
57	opioid receptor signaling pathway (GO:0038003)	2.85714611
58	regulation of telomere maintenance (GO:0032204)	2.82309917
59	regulation of meiosis I (GO:0060631)	2.81595698
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81568519
61	cellular ketone body metabolic process (GO:0046950)	2.80735297
62	retinal ganglion cell axon guidance (GO:0031290)	2.80191426
63	quinone biosynthetic process (GO:1901663)	2.78286693
64	eye photoreceptor cell development (GO:0042462)	2.76924702
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75456940
66	regulation of plasminogen activation (GO:0010755)	2.75223080
67	succinate metabolic process (GO:0006105)	2.73371771
68	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.71861114
69	interferon-gamma production (GO:0032609)	2.71160067
70	regulation of microtubule-based movement (GO:0060632)	2.71146906
71	short-chain fatty acid metabolic process (GO:0046459)	2.70555380
72	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.68973290
73	NADH dehydrogenase complex assembly (GO:0010257)	2.68973290
74	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.68973290
75	regulation of timing of cell differentiation (GO:0048505)	2.67768035
76	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.67278261
77	histone H3-K36 demethylation (GO:0070544)	2.66814351
78	regulation of appetite (GO:0032098)	2.66700898
79	cullin deneddylation (GO:0010388)	2.66523008
80	anterograde axon cargo transport (GO:0008089)	2.64068055
81	CTP metabolic process (GO:0046036)	2.64040212
82	CTP biosynthetic process (GO:0006241)	2.64040212
83	protein deneddylation (GO:0000338)	2.63908058
84	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.62923338
85	UTP metabolic process (GO:0046051)	2.62254386
86	cilium movement (GO:0003341)	2.61826389
87	regulation of development, heterochronic (GO:0040034)	2.60489056
88	cilium organization (GO:0044782)	2.60047218
89	protein localization to synapse (GO:0035418)	2.59858306
90	urogenital system development (GO:0001655)	2.58898347
91	limb development (GO:0060173)	2.57094547
92	appendage development (GO:0048736)	2.57094547
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56285990
94	establishment of protein localization to Golgi (GO:0072600)	2.56218903
95	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.55923580
96	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.55923580
97	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.55257076
98	detection of light stimulus involved in sensory perception (GO:0050962)	2.55178785
99	detection of light stimulus involved in visual perception (GO:0050908)	2.55178785
100	protein targeting to Golgi (GO:0000042)	2.53338006

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.42003873
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.77484860
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.45510717
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39905695
5	VDR_22108803_ChIP-Seq_LS180_Human	2.73186433
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.67016563
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.56257621
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53176421
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.39513431
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38515142
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36258714
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.31174107
13	FUS_26573619_Chip-Seq_HEK293_Human	2.17469719
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14161041
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.10053773
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09108586
17	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.08153273
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.98263530
19	EWS_26573619_Chip-Seq_HEK293_Human	1.93034617
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.87112718
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85654322
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79679243
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.72570020
24	P300_19829295_ChIP-Seq_ESCs_Human	1.70286579
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.69781636
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61607153
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.61607153
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54739502
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.53389703
30	NCOR_22424771_ChIP-Seq_293T_Human	1.52967954
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52552226
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51917393
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.49519036
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47687270
35	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.45522907
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44734308
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.42445726
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41690388
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.41184461
40	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.40370946
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39563791
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.39051771
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37134195
44	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.36997502
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.36773189
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.35656523
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34758591
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34401385
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.29833047
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.27665431
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27216316
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27150116
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26752975
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23781199
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22862481
56	AR_20517297_ChIP-Seq_VCAP_Human	1.20800458
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.20612176
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19410799
59	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.18849597
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18814107
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18702622
62	* ERA_21632823_ChIP-Seq_H3396_Human	1.16873889
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16475911
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16073784
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16073784
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.16056016
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15643117
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15176090
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15176090
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.09589082
71	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09087007
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07154890
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03270087
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02971581
75	TCF4_23295773_ChIP-Seq_U87_Human	1.01475911
76	TTF2_22483619_ChIP-Seq_HELA_Human	0.98913141
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.98689456
78	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98644752
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98242326
80	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96172045
81	RAC3_21632823_ChIP-Seq_H3396_Human	0.96116532
82	STAT3_23295773_ChIP-Seq_U87_Human	0.95885663
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95757599
84	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95621763
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93429135
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91996934
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91996934
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.91640169
89	AR_25329375_ChIP-Seq_VCAP_Human	0.90909952
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90133224
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89848989
92	DROSHA_22980978_ChIP-Seq_HELA_Human	0.89751823
93	GABP_19822575_ChIP-Seq_HepG2_Human	0.88736292
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88704003
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.88352342
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88257935
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.87841840
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86982700
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86269083
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86267392

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001348_abnormal_lacrimal_gland	4.80665023
2	MP0000566_synostosis	3.54538001
3	MP0006072_abnormal_retinal_apoptosis	2.93718541
4	MP0001299_abnormal_eye_distance/	2.93421783
5	MP0005253_abnormal_eye_physiology	2.78674618
6	MP0008877_abnormal_DNA_methylation	2.64586835
7	MP0002102_abnormal_ear_morphology	2.54234207
8	MP0003646_muscle_fatigue	2.53653756
9	MP0003880_abnormal_central_pattern	2.44297584
10	MP0002736_abnormal_nociception_after	2.41471273
11	MP0003890_abnormal_embryonic-extraembry	2.39048794
12	MP0002653_abnormal_ependyma_morphology	2.31288561
13	MP0005551_abnormal_eye_electrophysiolog	2.23677908
14	MP0001968_abnormal_touch/_nociception	2.21168508
15	MP0001529_abnormal_vocalization	2.15733348
16	MP0006276_abnormal_autonomic_nervous	2.04278879
17	MP0008058_abnormal_DNA_repair	2.03928903
18	MP0009046_muscle_twitch	1.96569849
19	MP0003195_calcinosis	1.93165531
20	MP0004145_abnormal_muscle_electrophysio	1.91500141
21	MP0004133_heterotaxia	1.81328909
22	MP0001984_abnormal_olfaction	1.80393052
23	MP0004742_abnormal_vestibular_system	1.74215870
24	MP0002751_abnormal_autonomic_nervous	1.73391442
25	MP0003136_yellow_coat_color	1.70732556
26	MP0003567_abnormal_fetal_cardiomyocyte	1.69552860
27	MP0008789_abnormal_olfactory_epithelium	1.64151114
28	MP0001486_abnormal_startle_reflex	1.60455651
29	MP0008775_abnormal_heart_ventricle	1.59869520
30	MP0000569_abnormal_digit_pigmentation	1.59804531
31	MP0003786_premature_aging	1.58600289
32	MP0005499_abnormal_olfactory_system	1.58254545
33	MP0005394_taste/olfaction_phenotype	1.58254545
34	MP0004885_abnormal_endolymph	1.57088110
35	MP0000372_irregular_coat_pigmentation	1.55239808
36	MP0002272_abnormal_nervous_system	1.48565539
37	MP0000026_abnormal_inner_ear	1.45135091
38	MP0006035_abnormal_mitochondrial_morpho	1.40748337
39	MP0009745_abnormal_behavioral_response	1.36402527
40	MP0002837_dystrophic_cardiac_calcinosis	1.36166584
41	MP0005391_vision/eye_phenotype	1.34272169
42	MP0002557_abnormal_social/conspecific_i	1.30994744
43	MP0003635_abnormal_synaptic_transmissio	1.26045716
44	MP0008872_abnormal_physiological_respon	1.23284146
45	MP0001963_abnormal_hearing_physiology	1.18089151
46	MP0002572_abnormal_emotion/affect_behav	1.16176719
47	MP0002067_abnormal_sensory_capabilities	1.11334901
48	MP0010094_abnormal_chromosome_stability	1.09538300
49	MP0002938_white_spotting	1.05669743
50	MP0000631_abnormal_neuroendocrine_gland	1.05501371
51	MP0003950_abnormal_plasma_membrane	1.04853889
52	MP0002909_abnormal_adrenal_gland	1.03538198
53	MP0003011_delayed_dark_adaptation	1.02320478
54	MP0006292_abnormal_olfactory_placode	1.00769566
55	MP0001501_abnormal_sleep_pattern	1.00766768
56	MP0005195_abnormal_posterior_eye	1.00613462
57	MP0000537_abnormal_urethra_morphology	1.00117900
58	MP0004142_abnormal_muscle_tone	0.99063641
59	MP0000049_abnormal_middle_ear	0.99040463
60	MP0002063_abnormal_learning/memory/cond	0.99007383
61	MP0003866_abnormal_defecation	0.97317407
62	MP0005671_abnormal_response_to	0.96914173
63	MP0009384_cardiac_valve_regurgitation	0.96390528
64	MP0005410_abnormal_fertilization	0.96163218
65	MP0005171_absent_coat_pigmentation	0.94939616
66	MP0009764_decreased_sensitivity_to	0.94226457
67	MP0000427_abnormal_hair_cycle	0.93314879
68	MP0001664_abnormal_digestion	0.92629547
69	MP0002090_abnormal_vision	0.92377350
70	MP0000778_abnormal_nervous_system	0.90205493
71	MP0003937_abnormal_limbs/digits/tail_de	0.89730069
72	MP0001970_abnormal_pain_threshold	0.89229431
73	MP0002752_abnormal_somatic_nervous	0.89185961
74	MP0003121_genomic_imprinting	0.88934231
75	MP0005075_abnormal_melanosome_morpholog	0.86998978
76	MP0004147_increased_porphyrin_level	0.85029460
77	MP0003119_abnormal_digestive_system	0.82131230
78	MP0005646_abnormal_pituitary_gland	0.81760827
79	MP0002882_abnormal_neuron_morphology	0.81568833
80	MP0004043_abnormal_pH_regulation	0.80313731
81	MP0002064_seizures	0.79694720
82	MP0005083_abnormal_biliary_tract	0.78848313
83	MP0003698_abnormal_male_reproductive	0.77787445
84	MP0002876_abnormal_thyroid_physiology	0.76027045
85	MP0002229_neurodegeneration	0.74859603
86	MP0003186_abnormal_redox_activity	0.74592180
87	MP0008995_early_reproductive_senescence	0.73942047
88	MP0002928_abnormal_bile_duct	0.73901167
89	MP0000955_abnormal_spinal_cord	0.73397811
90	MP0003878_abnormal_ear_physiology	0.73016282
91	MP0005377_hearing/vestibular/ear_phenot	0.73016282
92	MP0002210_abnormal_sex_determination	0.71876508
93	MP0003045_fibrosis	0.71781497
94	MP0005408_hypopigmentation	0.70248948
95	MP0001919_abnormal_reproductive_system	0.69457528
96	MP0001324_abnormal_eye_pigmentation	0.69292542
97	MP0001145_abnormal_male_reproductive	0.69049352
98	MP0003633_abnormal_nervous_system	0.68240509
99	MP0008007_abnormal_cellular_replicative	0.67666391
100	MP0005360_urolithiasis	0.67345620

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	5.06394738
2	Retrobulbar optic neuritis (HP:0100654)	3.98243240
3	Optic neuritis (HP:0100653)	3.98243240
4	True hermaphroditism (HP:0010459)	3.57938142
5	Pancreatic cysts (HP:0001737)	3.55247621
6	Abnormal number of erythroid precursors (HP:0012131)	3.51505103
7	Orchitis (HP:0100796)	3.28706607
8	Gait imbalance (HP:0002141)	3.07567345
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.04117719
10	Congenital primary aphakia (HP:0007707)	2.97548792
11	Medial flaring of the eyebrow (HP:0010747)	2.97108422
12	Abnormality of midbrain morphology (HP:0002418)	2.92092691
13	Molar tooth sign on MRI (HP:0002419)	2.92092691
14	Chronic hepatic failure (HP:0100626)	2.90516268
15	Cystic liver disease (HP:0006706)	2.89702111
16	Myositis (HP:0100614)	2.88450159
17	Tubulointerstitial fibrosis (HP:0005576)	2.84665304
18	Colon cancer (HP:0003003)	2.70070616
19	Nephrogenic diabetes insipidus (HP:0009806)	2.69341031
20	Congenital stationary night blindness (HP:0007642)	2.66870259
21	Type II lissencephaly (HP:0007260)	2.61396000
22	Postaxial foot polydactyly (HP:0001830)	2.54654441
23	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.53183877
24	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.53183877
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51415763
26	Absent/shortened dynein arms (HP:0200106)	2.51415763
27	Tubulointerstitial abnormality (HP:0001969)	2.50997517
28	Ketoacidosis (HP:0001993)	2.45249863
29	Keratoconjunctivitis sicca (HP:0001097)	2.43948592
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.43056817
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.43056817
32	Hyperglycinemia (HP:0002154)	2.42758959
33	Nephronophthisis (HP:0000090)	2.40490850
34	Rectal prolapse (HP:0002035)	2.40356568
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35743499
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35743499
37	Tetraparesis (HP:0002273)	2.35193533
38	Abnormal ciliary motility (HP:0012262)	2.31225345
39	Genital tract atresia (HP:0001827)	2.30846625
40	Abnormality of the renal cortex (HP:0011035)	2.29912196
41	Keratoconjunctivitis (HP:0001096)	2.29522787
42	Humeroradial synostosis (HP:0003041)	2.29439145
43	Synostosis involving the elbow (HP:0003938)	2.29439145
44	Sclerocornea (HP:0000647)	2.29264185
45	Abnormality of the renal medulla (HP:0100957)	2.28753018
46	Poor coordination (HP:0002370)	2.24996551
47	Vaginal atresia (HP:0000148)	2.22875642
48	Congenital hepatic fibrosis (HP:0002612)	2.21695202
49	Occipital encephalocele (HP:0002085)	2.21601034
50	Pachygyria (HP:0001302)	2.19886549
51	Intestinal atresia (HP:0011100)	2.17567372
52	Ketosis (HP:0001946)	2.17155655
53	Preaxial hand polydactyly (HP:0001177)	2.14312418
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.14305015
55	Increased corneal curvature (HP:0100692)	2.09901628
56	Keratoconus (HP:0000563)	2.09901628
57	CNS hypomyelination (HP:0003429)	2.08755356
58	Double outlet right ventricle (HP:0001719)	2.07086262
59	Congenital malformation of the right heart (HP:0011723)	2.07086262
60	Biliary tract neoplasm (HP:0100574)	2.06712655
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06275297
62	Anencephaly (HP:0002323)	2.03780056
63	Chromsome breakage (HP:0040012)	2.02507193
64	Ependymoma (HP:0002888)	2.00768518
65	Progressive microcephaly (HP:0000253)	1.97427823
66	Tubular atrophy (HP:0000092)	1.96442916
67	Shawl scrotum (HP:0000049)	1.93626184
68	Aganglionic megacolon (HP:0002251)	1.91651113
69	Glioma (HP:0009733)	1.90366842
70	Prolonged partial thromboplastin time (HP:0003645)	1.88432354
71	Degeneration of anterior horn cells (HP:0002398)	1.87887049
72	Abnormality of the anterior horn cell (HP:0006802)	1.87887049
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87464511
74	Abnormality of glycine metabolism (HP:0010895)	1.87362719
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87362719
76	Retinitis pigmentosa (HP:0000510)	1.87077506
77	Abnormal biliary tract physiology (HP:0012439)	1.86419437
78	Bile duct proliferation (HP:0001408)	1.86419437
79	Abnormality of chromosome stability (HP:0003220)	1.85979624
80	Conical tooth (HP:0000698)	1.85383890
81	Increased CSF lactate (HP:0002490)	1.84192232
82	Hyperventilation (HP:0002883)	1.83388453
83	Pendular nystagmus (HP:0012043)	1.83334679
84	Hypoplastic iliac wings (HP:0002866)	1.82817997
85	Oligodontia (HP:0000677)	1.82635399
86	Intestinal polyposis (HP:0200008)	1.81930639
87	Cerebral hypomyelination (HP:0006808)	1.81901993
88	Abnormality of the labia minora (HP:0012880)	1.81197565
89	Postaxial hand polydactyly (HP:0001162)	1.80724404
90	Acute necrotizing encephalopathy (HP:0006965)	1.79381619
91	Retinal dysplasia (HP:0007973)	1.79201236
92	Medulloblastoma (HP:0002885)	1.77581214
93	Reticulocytopenia (HP:0001896)	1.77176138
94	Focal motor seizures (HP:0011153)	1.76889464
95	Abnormal mitochondria in muscle tissue (HP:0008316)	1.76545911
96	Broad-based gait (HP:0002136)	1.76115806
97	Abnormal albumin level (HP:0012116)	1.75755262
98	Hypoalbuminemia (HP:0003073)	1.75755262
99	Cerebellar dysplasia (HP:0007033)	1.75594353
100	Thyroid-stimulating hormone excess (HP:0002925)	1.74890068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	5.14437172
2	MAP4K2	4.61838727
3	MAP2K6	3.85747745
4	ADRBK2	3.18116338
5	INSRR	2.84597363
6	PINK1	2.76617780
7	TXK	2.52520655
8	EPHB2	2.38566493
9	BCR	2.17375732
10	EPHA4	2.07400427
11	FRK	1.99254418
12	STK16	1.87171470
13	EPHB1	1.80496978
14	NLK	1.74667330
15	MAP3K4	1.62469228
16	PAK3	1.60423784
17	WNK3	1.58025389
18	IRAK1	1.52391194
19	WNK4	1.52391001
20	DYRK2	1.47799064
21	PDK2	1.42665689
22	FGFR2	1.42575226
23	MAP3K11	1.37929927
24	MAP3K13	1.36803092
25	ZAK	1.32236366
26	CSNK1G2	1.29386402
27	MARK1	1.27434455
28	BCKDK	1.21036100
29	BMPR1B	1.17628758
30	ERBB2	1.16382872
31	NEK2	1.14382056
32	MAPK13	1.13409261
33	MAP2K7	1.12532694
34	CSNK1A1L	1.11895609
35	SRPK1	1.09976506
36	GRK1	1.09956396
37	SIK2	1.05051856
38	CSNK1G3	1.03978014
39	PASK	1.02437045
40	ITK	0.98777460
41	TLK1	0.97686968
42	VRK2	0.93822355
43	RPS6KA4	0.93440224
44	CSNK1G1	0.90366914
45	TYRO3	0.85780350
46	KSR1	0.85123124
47	PRKCE	0.84693991
48	CAMKK2	0.82094648
49	DYRK3	0.81925810
50	PRKCZ	0.77812490
51	TGFBR1	0.74709230
52	PAK6	0.74365935
53	MINK1	0.72878891
54	PRKCG	0.72630763
55	CCNB1	0.68508917
56	CASK	0.68507390
57	PLK4	0.68038747
58	ADRBK1	0.66968728
59	FER	0.63960227
60	RPS6KA5	0.62152409
61	MAPK15	0.61354769
62	PRKCQ	0.60573569
63	TEC	0.58694512
64	OXSR1	0.58526119
65	VRK1	0.57241189
66	CHUK	0.54572562
67	NME1	0.54179287
68	ERBB3	0.53871470
69	TGFBR2	0.53609281
70	CSNK1A1	0.49071946
71	GRK5	0.46851165
72	FGFR1	0.46698581
73	NEK1	0.45770361
74	TNK2	0.44432774
75	FLT3	0.44166425
76	TRIM28	0.43226422
77	CAMK4	0.43184121
78	TAF1	0.42984612
79	BTK	0.41832561
80	NUAK1	0.38781923
81	CAMK2A	0.38620919
82	PLK1	0.38159624
83	GRK6	0.37897190
84	PHKG2	0.37555555
85	PHKG1	0.37555555
86	ATR	0.35936287
87	PRKACA	0.35758804
88	PNCK	0.33471578
89	FGFR4	0.31263507
90	KIT	0.29224190
91	WEE1	0.27766806
92	BMPR2	0.27604711
93	PRKCA	0.27479862
94	PRKCB	0.24984808
95	IGF1R	0.24381510
96	PRKAA2	0.24375117
97	IKBKB	0.24112323
98	TIE1	0.23846710
99	PLK2	0.23093313
100	OBSCN	0.21198171

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.74896999
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.34108440
3	Homologous recombination_Homo sapiens_hsa03440	3.30913540
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74940692
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.65930834
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.54657716
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.50583359
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.41465972
9	Protein export_Homo sapiens_hsa03060	2.40172753
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20534326
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12771585
12	Butanoate metabolism_Homo sapiens_hsa00650	2.07399087
13	Parkinsons disease_Homo sapiens_hsa05012	2.02602187
14	Ribosome_Homo sapiens_hsa03010	1.99762142
15	Huntingtons disease_Homo sapiens_hsa05016	1.89835064
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.89048433
17	Propanoate metabolism_Homo sapiens_hsa00640	1.82932584
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81113036
19	Phototransduction_Homo sapiens_hsa04744	1.78369749
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77614534
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74744514
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.46942127
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46586538
24	Nicotine addiction_Homo sapiens_hsa05033	1.44883041
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44402054
26	Mismatch repair_Homo sapiens_hsa03430	1.42897524
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.42205150
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.37837920
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32905305
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.30870801
31	Basal transcription factors_Homo sapiens_hsa03022	1.29197957
32	Alzheimers disease_Homo sapiens_hsa05010	1.27144967
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.20403212
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.13300283
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09944765
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08493350
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07886100
38	Sulfur relay system_Homo sapiens_hsa04122	1.07410442
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07233541
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06139111
41	Peroxisome_Homo sapiens_hsa04146	1.04747331
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00446268
43	Purine metabolism_Homo sapiens_hsa00230	0.96546255
44	Olfactory transduction_Homo sapiens_hsa04740	0.93640120
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.91546563
46	Taste transduction_Homo sapiens_hsa04742	0.90583637
47	Asthma_Homo sapiens_hsa05310	0.90319394
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86623054
49	Proteasome_Homo sapiens_hsa03050	0.85949978
50	Regulation of autophagy_Homo sapiens_hsa04140	0.85848753
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85807607
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.84198868
53	RNA degradation_Homo sapiens_hsa03018	0.84179843
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80279443
55	Metabolic pathways_Homo sapiens_hsa01100	0.79234972
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76996318
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.75523175
58	Morphine addiction_Homo sapiens_hsa05032	0.72891048
59	GABAergic synapse_Homo sapiens_hsa04727	0.71247019
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71093015
61	Fatty acid elongation_Homo sapiens_hsa00062	0.69578712
62	Base excision repair_Homo sapiens_hsa03410	0.67627609
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.65986609
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65241346
65	Lysine degradation_Homo sapiens_hsa00310	0.64749020
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63966451
67	Retinol metabolism_Homo sapiens_hsa00830	0.63628998
68	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.62977577
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60572559
70	Caffeine metabolism_Homo sapiens_hsa00232	0.60564927
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59434326
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57305117
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.56910409
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55969956
75	Oocyte meiosis_Homo sapiens_hsa04114	0.53929863
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52950110
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.52668562
78	Allograft rejection_Homo sapiens_hsa05330	0.51693100
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50777665
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50238624
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50132756
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49888807
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49864485
84	One carbon pool by folate_Homo sapiens_hsa00670	0.49585476
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49354132
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48673436
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48011133
88	Salivary secretion_Homo sapiens_hsa04970	0.46722579
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43979859
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43285136
91	ABC transporters_Homo sapiens_hsa02010	0.43013014
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42379043
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37697959
94	Circadian entrainment_Homo sapiens_hsa04713	0.35482837
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33786913
96	Fatty acid degradation_Homo sapiens_hsa00071	0.32278013
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29667779
98	Serotonergic synapse_Homo sapiens_hsa04726	0.29087742
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.27421115
100	RNA transport_Homo sapiens_hsa03013	0.24396388

SPDYE7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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