ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.95098129
2	piRNA metabolic process (GO:0034587)	4.78531921
3	ether lipid metabolic process (GO:0046485)	4.24093454
4	opioid receptor signaling pathway (GO:0038003)	4.15961899
5	regulation of cilium movement (GO:0003352)	4.02730589
6	behavioral response to ethanol (GO:0048149)	3.96093301
7	ubiquinone biosynthetic process (GO:0006744)	3.92732686
8	epithelial cilium movement (GO:0003351)	3.90292911
9	tryptophan catabolic process (GO:0006569)	3.84166783
10	indole-containing compound catabolic process (GO:0042436)	3.84166783
11	indolalkylamine catabolic process (GO:0046218)	3.84166783
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73235974
13	response to pheromone (GO:0019236)	3.73171574
14	mannosylation (GO:0097502)	3.71216649
15	platelet dense granule organization (GO:0060155)	3.70010968
16	indolalkylamine metabolic process (GO:0006586)	3.65253526
17	intraciliary transport (GO:0042073)	3.56794596
18	ubiquinone metabolic process (GO:0006743)	3.56400326
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.55878903
20	tryptophan metabolic process (GO:0006568)	3.55629934
21	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.54208330
22	quinone biosynthetic process (GO:1901663)	3.47762470
23	GPI anchor metabolic process (GO:0006505)	3.47479128
24	neural tube formation (GO:0001841)	3.46124843
25	axoneme assembly (GO:0035082)	3.44741413
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42813301
27	protein complex biogenesis (GO:0070271)	3.42601190
28	replication fork processing (GO:0031297)	3.42342784
29	photoreceptor cell maintenance (GO:0045494)	3.40265342
30	DNA integration (GO:0015074)	3.36382122
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26373188
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26373188
33	NADH dehydrogenase complex assembly (GO:0010257)	3.26373188
34	cytochrome complex assembly (GO:0017004)	3.19019068
35	retinal cone cell development (GO:0046549)	3.16388988
36	respiratory chain complex IV assembly (GO:0008535)	3.15420242
37	cellular biogenic amine catabolic process (GO:0042402)	3.13124841
38	amine catabolic process (GO:0009310)	3.13124841
39	GPI anchor biosynthetic process (GO:0006506)	3.12329127
40	cilium movement (GO:0003341)	3.10730882
41	DNA double-strand break processing (GO:0000729)	3.08406096
42	glycerol ether metabolic process (GO:0006662)	3.08253006
43	DNA methylation involved in gamete generation (GO:0043046)	3.02157290
44	C4-dicarboxylate transport (GO:0015740)	3.01947614
45	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.01766376
46	seminiferous tubule development (GO:0072520)	3.00969648
47	adult feeding behavior (GO:0008343)	2.98463557
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98423751
49	centriole replication (GO:0007099)	2.98268122
50	detection of light stimulus involved in visual perception (GO:0050908)	2.97104324
51	detection of light stimulus involved in sensory perception (GO:0050962)	2.97104324
52	GMP metabolic process (GO:0046037)	2.89515986
53	branched-chain amino acid catabolic process (GO:0009083)	2.88611455
54	ether metabolic process (GO:0018904)	2.88307378
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.88220542
56	cilium or flagellum-dependent cell motility (GO:0001539)	2.87955611
57	nonmotile primary cilium assembly (GO:0035058)	2.84446928
58	C-terminal protein lipidation (GO:0006501)	2.84439945
59	cilium organization (GO:0044782)	2.81405458
60	protein polyglutamylation (GO:0018095)	2.79268476
61	cilium morphogenesis (GO:0060271)	2.79246532
62	male meiosis (GO:0007140)	2.78028139
63	spermatid development (GO:0007286)	2.77753916
64	cilium assembly (GO:0042384)	2.76685822
65	anterograde synaptic vesicle transport (GO:0048490)	2.75286098
66	glyoxylate metabolic process (GO:0046487)	2.73638455
67	regulation of microtubule-based movement (GO:0060632)	2.70544687
68	cellular ketone body metabolic process (GO:0046950)	2.69219857
69	aldehyde catabolic process (GO:0046185)	2.68867033
70	short-chain fatty acid metabolic process (GO:0046459)	2.67540816
71	cornea development in camera-type eye (GO:0061303)	2.67480059
72	sperm motility (GO:0030317)	2.67351491
73	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.66711828
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.66711828
75	C-terminal protein amino acid modification (GO:0018410)	2.65010032
76	gamma-aminobutyric acid transport (GO:0015812)	2.62839417
77	DNA deamination (GO:0045006)	2.62778590
78	histone H2A acetylation (GO:0043968)	2.61994371
79	ncRNA catabolic process (GO:0034661)	2.61844372
80	aspartate family amino acid catabolic process (GO:0009068)	2.61240495
81	fucose catabolic process (GO:0019317)	2.61171966
82	L-fucose metabolic process (GO:0042354)	2.61171966
83	L-fucose catabolic process (GO:0042355)	2.61171966
84	negative regulation of cAMP-mediated signaling (GO:0043951)	2.61145768
85	adenosine metabolic process (GO:0046085)	2.60897886
86	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.58711464
87	inositol phosphate catabolic process (GO:0071545)	2.57601217
88	glycolipid biosynthetic process (GO:0009247)	2.56972109
89	branched-chain amino acid metabolic process (GO:0009081)	2.56443653
90	protein K6-linked ubiquitination (GO:0085020)	2.56031098
91	synapsis (GO:0007129)	2.54687695
92	positive regulation of developmental pigmentation (GO:0048087)	2.53638480
93	mitochondrial RNA metabolic process (GO:0000959)	2.53132972
94	pyrimidine dimer repair (GO:0006290)	2.51564392
95	recombinational repair (GO:0000725)	2.51510719
96	estrogen biosynthetic process (GO:0006703)	2.51427177
97	thrombin receptor signaling pathway (GO:0070493)	2.51194980
98	regulation of MHC class II biosynthetic process (GO:0045346)	2.50966054
99	pyrimidine nucleotide catabolic process (GO:0006244)	2.48678852
100	double-strand break repair via homologous recombination (GO:0000724)	2.47603747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.11734206
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.10806236
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.89178961
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.85353218
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.83585599
6	VDR_22108803_ChIP-Seq_LS180_Human	2.78603214
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.72647662
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67930724
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44871397
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33102179
11	FUS_26573619_Chip-Seq_HEK293_Human	2.29768174
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.27328218
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.26425550
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.22886069
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20241028
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16841994
17	EWS_26573619_Chip-Seq_HEK293_Human	2.15563655
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13976221
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.09607691
20	IRF1_19129219_ChIP-ChIP_H3396_Human	2.01578330
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92600676
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90484661
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87612276
24	P300_19829295_ChIP-Seq_ESCs_Human	1.85922374
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83591057
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.70945917
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70945917
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67108752
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.64948058
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.64626473
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.64143157
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61936777
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61936777
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60170858
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57448828
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.56559958
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56106542
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56040289
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.55028513
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48595633
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48595633
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46794704
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.45489135
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45200328
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44570353
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42296851
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41504345
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40002101
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39296796
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.36746442
51	STAT3_23295773_ChIP-Seq_U87_Human	1.35426581
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33512441
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28521426
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26229148
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25729782
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24855073
57	TCF4_23295773_ChIP-Seq_U87_Human	1.24760379
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24153543
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23155502
60	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.22952635
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21088265
62	AR_25329375_ChIP-Seq_VCAP_Human	1.17675652
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14631271
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14463517
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14215723
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12569839
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12569839
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11772351
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10389518
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09886402
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.09042196
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08529041
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07980013
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.07484987
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.06957004
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05098549
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04733666
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04173541
79	NCOR_22424771_ChIP-Seq_293T_Human	1.03601054
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02829979
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02481343
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02268998
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02173022
84	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00819465
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99853588
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99468492
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99292202
88	AR_20517297_ChIP-Seq_VCAP_Human	0.99009624
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98442636
90	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98275423
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97830456
92	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96164747
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95445162
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95266995
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95214376
96	SCL_19346495_ChIP-Seq_HPC-7_Human	0.95061767
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93724649
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92976048
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91307772
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90707363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.07020281
2	MP0001968_abnormal_touch/_nociception	2.93009287
3	MP0009278_abnormal_bone_marrow	2.88999558
4	MP0008877_abnormal_DNA_methylation	2.65950556
5	MP0000015_abnormal_ear_pigmentation	2.58752693
6	MP0000372_irregular_coat_pigmentation	2.51170688
7	MP0005551_abnormal_eye_electrophysiolog	2.50126291
8	MP0008058_abnormal_DNA_repair	2.49029945
9	MP0002876_abnormal_thyroid_physiology	2.24993760
10	MP0003136_yellow_coat_color	2.23334429
11	MP0002638_abnormal_pupillary_reflex	2.13539411
12	MP0006292_abnormal_olfactory_placode	2.12197336
13	MP0003718_maternal_effect	2.06737276
14	MP0002102_abnormal_ear_morphology	2.03324950
15	MP0005075_abnormal_melanosome_morpholog	2.01151651
16	MP0005174_abnormal_tail_pigmentation	1.99157381
17	MP0005646_abnormal_pituitary_gland	1.93067186
18	MP0001986_abnormal_taste_sensitivity	1.87423112
19	MP0006276_abnormal_autonomic_nervous	1.85640517
20	MP0005645_abnormal_hypothalamus_physiol	1.85141562
21	MP0008995_early_reproductive_senescence	1.79515782
22	MP0008875_abnormal_xenobiotic_pharmacok	1.78232839
23	MP0000569_abnormal_digit_pigmentation	1.76218312
24	MP0002736_abnormal_nociception_after	1.75187159
25	MP0002095_abnormal_skin_pigmentation	1.73664989
26	MP0003195_calcinosis	1.72465244
27	MP0005397_hematopoietic_system_phenotyp	1.69484800
28	MP0001545_abnormal_hematopoietic_system	1.69484800
29	MP0006072_abnormal_retinal_apoptosis	1.67101684
30	MP0001529_abnormal_vocalization	1.64676096
31	MP0002938_white_spotting	1.63687307
32	MP0010094_abnormal_chromosome_stability	1.62338461
33	MP0001486_abnormal_startle_reflex	1.60977554
34	MP0006035_abnormal_mitochondrial_morpho	1.60562981
35	MP0002234_abnormal_pharynx_morphology	1.54107021
36	MP0002735_abnormal_chemical_nociception	1.52646884
37	MP0009046_muscle_twitch	1.52126389
38	MP0008872_abnormal_physiological_respon	1.51273076
39	MP0005253_abnormal_eye_physiology	1.51166889
40	MP0003787_abnormal_imprinting	1.43062703
41	MP0005410_abnormal_fertilization	1.42741900
42	MP0001984_abnormal_olfaction	1.39695554
43	MP0004043_abnormal_pH_regulation	1.38050074
44	MP0001501_abnormal_sleep_pattern	1.36147132
45	MP0002653_abnormal_ependyma_morphology	1.31582429
46	MP0004147_increased_porphyrin_level	1.29445135
47	MP0005171_absent_coat_pigmentation	1.28700173
48	MP0009745_abnormal_behavioral_response	1.27341997
49	MP0003806_abnormal_nucleotide_metabolis	1.24088094
50	MP0006036_abnormal_mitochondrial_physio	1.23880405
51	MP0003121_genomic_imprinting	1.23829777
52	MP0003698_abnormal_male_reproductive	1.19276603
53	MP0003122_maternal_imprinting	1.17469293
54	MP0001764_abnormal_homeostasis	1.17271092
55	MP0001929_abnormal_gametogenesis	1.16284745
56	MP0008789_abnormal_olfactory_epithelium	1.12954411
57	MP0000566_synostosis	1.12542117
58	MP0001905_abnormal_dopamine_level	1.12112279
59	MP0002272_abnormal_nervous_system	1.09271851
60	MP0010386_abnormal_urinary_bladder	1.08875161
61	MP0005423_abnormal_somatic_nervous	1.07242387
62	MP0002160_abnormal_reproductive_system	1.03478315
63	MP0002751_abnormal_autonomic_nervous	0.99771062
64	MP0009764_decreased_sensitivity_to	0.99421865
65	MP0002064_seizures	0.97632361
66	MP0000465_gastrointestinal_hemorrhage	0.97133848
67	MP0004133_heterotaxia	0.95463471
68	MP0005084_abnormal_gallbladder_morpholo	0.95425541
69	MP0000631_abnormal_neuroendocrine_gland	0.94319989
70	MP0002733_abnormal_thermal_nociception	0.94314504
71	MP0009697_abnormal_copulation	0.93838158
72	MP0001324_abnormal_eye_pigmentation	0.93819566
73	MP0001970_abnormal_pain_threshold	0.91474758
74	MP0001664_abnormal_digestion	0.91373519
75	MP0005085_abnormal_gallbladder_physiolo	0.90656750
76	MP0005195_abnormal_posterior_eye	0.90579356
77	MP0002067_abnormal_sensory_capabilities	0.89990710
78	MP0002557_abnormal_social/conspecific_i	0.89433650
79	MP0002572_abnormal_emotion/affect_behav	0.87522440
80	MP0005499_abnormal_olfactory_system	0.87402261
81	MP0005394_taste/olfaction_phenotype	0.87402261
82	MP0002282_abnormal_trachea_morphology	0.86726653
83	MP0004142_abnormal_muscle_tone	0.86518272
84	MP0005395_other_phenotype	0.82118519
85	MP0002210_abnormal_sex_determination	0.82109816
86	MP0000653_abnormal_sex_gland	0.81638651
87	MP0001963_abnormal_hearing_physiology	0.80532582
88	MP0002752_abnormal_somatic_nervous	0.79900721
89	MP0003646_muscle_fatigue	0.78128977
90	MP0003635_abnormal_synaptic_transmissio	0.77886855
91	MP0001145_abnormal_male_reproductive	0.76618242
92	MP0004742_abnormal_vestibular_system	0.71263960
93	MP0005389_reproductive_system_phenotype	0.70359078
94	MP0003567_abnormal_fetal_cardiomyocyte	0.69430527
95	MP0002069_abnormal_eating/drinking_beha	0.69222525
96	MP0000358_abnormal_cell_content/	0.67990657
97	MP0002837_dystrophic_cardiac_calcinosis	0.67873432
98	MP0001485_abnormal_pinna_reflex	0.67319018
99	MP0002229_neurodegeneration	0.67227766
100	MP0001293_anophthalmia	0.66938691

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	4.42580672
2	Pancreatic fibrosis (HP:0100732)	3.77208531
3	Pancreatic cysts (HP:0001737)	3.74432789
4	True hermaphroditism (HP:0010459)	3.70511221
5	Medial flaring of the eyebrow (HP:0010747)	3.48693274
6	Molar tooth sign on MRI (HP:0002419)	3.28873230
7	Abnormality of midbrain morphology (HP:0002418)	3.28873230
8	Focal motor seizures (HP:0011153)	3.26018431
9	Congenital stationary night blindness (HP:0007642)	3.11918923
10	Nephronophthisis (HP:0000090)	3.05909392
11	Hyperventilation (HP:0002883)	3.04165511
12	Congenital primary aphakia (HP:0007707)	2.98416073
13	Gait imbalance (HP:0002141)	2.97854827
14	Nephrogenic diabetes insipidus (HP:0009806)	2.88393641
15	Tubulointerstitial nephritis (HP:0001970)	2.87647538
16	Hepatocellular necrosis (HP:0001404)	2.84976656
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.68486417
18	Inability to walk (HP:0002540)	2.68239581
19	Abnormality of the renal medulla (HP:0100957)	2.67556268
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.63705904
21	Intestinal atresia (HP:0011100)	2.61878846
22	Hyperglycinemia (HP:0002154)	2.60630623
23	Genital tract atresia (HP:0001827)	2.60491022
24	Cerebellar dysplasia (HP:0007033)	2.59421066
25	Progressive inability to walk (HP:0002505)	2.58664454
26	Volvulus (HP:0002580)	2.58411741
27	Attenuation of retinal blood vessels (HP:0007843)	2.57663657
28	Decreased central vision (HP:0007663)	2.57075120
29	Cystic liver disease (HP:0006706)	2.54013460
30	Type II lissencephaly (HP:0007260)	2.53358869
31	Hepatic necrosis (HP:0002605)	2.52058277
32	Abnormality of macular pigmentation (HP:0008002)	2.50374825
33	Type I transferrin isoform profile (HP:0003642)	2.48521592
34	Vaginal atresia (HP:0000148)	2.48194360
35	Absent speech (HP:0001344)	2.47701994
36	Hyperglycinuria (HP:0003108)	2.45224365
37	Colon cancer (HP:0003003)	2.41113458
38	Gaze-evoked nystagmus (HP:0000640)	2.34912602
39	Mitochondrial inheritance (HP:0001427)	2.32747166
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31568000
41	Abnormality of the ileum (HP:0001549)	2.30156978
42	Poor head control (HP:0002421)	2.27908721
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26344646
44	Absent/shortened dynein arms (HP:0200106)	2.26344646
45	Increased CSF lactate (HP:0002490)	2.25855972
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25333262
47	Abnormal protein N-linked glycosylation (HP:0012347)	2.25333262
48	Abnormal protein glycosylation (HP:0012346)	2.25333262
49	Abnormal glycosylation (HP:0012345)	2.25333262
50	Short tibia (HP:0005736)	2.23598363
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23403720
52	Postaxial foot polydactyly (HP:0001830)	2.19024338
53	Abnormality of the renal cortex (HP:0011035)	2.18399096
54	Abnormality of the labia minora (HP:0012880)	2.17062265
55	Lissencephaly (HP:0001339)	2.16752158
56	Congenital hepatic fibrosis (HP:0002612)	2.16673302
57	Acute encephalopathy (HP:0006846)	2.16653775
58	Renal cortical cysts (HP:0000803)	2.15181371
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14985114
60	Methylmalonic acidemia (HP:0002912)	2.14402250
61	Methylmalonic aciduria (HP:0012120)	2.13229917
62	Abnormality of glycine metabolism (HP:0010895)	2.13124317
63	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13124317
64	Chronic hepatic failure (HP:0100626)	2.12649399
65	Optic nerve hypoplasia (HP:0000609)	2.12385478
66	Chromsome breakage (HP:0040012)	2.10152330
67	Hypothermia (HP:0002045)	2.09708133
68	Tented upper lip vermilion (HP:0010804)	2.07730991
69	Astigmatism (HP:0000483)	2.05174404
70	Retinitis pigmentosa (HP:0000510)	2.04804701
71	Acute necrotizing encephalopathy (HP:0006965)	2.04584992
72	Broad-based gait (HP:0002136)	2.03847445
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03779263
74	Pendular nystagmus (HP:0012043)	2.03518093
75	Abnormal respiratory epithelium morphology (HP:0012253)	2.02889675
76	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02889675
77	Abnormal ciliary motility (HP:0012262)	1.97809381
78	Male pseudohermaphroditism (HP:0000037)	1.97331898
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95604086
80	Retinal dysplasia (HP:0007973)	1.95285039
81	Sclerocornea (HP:0000647)	1.94975920
82	Anencephaly (HP:0002323)	1.94351779
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.93420911
84	Optic disc pallor (HP:0000543)	1.93391377
85	Stomach cancer (HP:0012126)	1.92972642
86	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92887369
87	Poor coordination (HP:0002370)	1.92880223
88	Abolished electroretinogram (ERG) (HP:0000550)	1.92700478
89	Keratoconus (HP:0000563)	1.91483877
90	Increased corneal curvature (HP:0100692)	1.91483877
91	Bile duct proliferation (HP:0001408)	1.91252434
92	Abnormal biliary tract physiology (HP:0012439)	1.91252434
93	Focal seizures (HP:0007359)	1.89018613
94	Pancreatic islet-cell hyperplasia (HP:0004510)	1.88398063
95	Abnormality of B cell number (HP:0010975)	1.88023801
96	Dialeptic seizures (HP:0011146)	1.87926696
97	Albinism (HP:0001022)	1.87102697
98	Postaxial hand polydactyly (HP:0001162)	1.85163337
99	Meckel diverticulum (HP:0002245)	1.84990928
100	Lipid accumulation in hepatocytes (HP:0006561)	1.84151767

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.07452252
2	FRK	3.75374140
3	ADRBK2	3.36872781
4	NUAK1	2.80437496
5	VRK2	2.75481533
6	WNK3	2.75273899
7	PINK1	2.75219757
8	BCKDK	2.74856334
9	ZAK	2.63369663
10	MAPK13	2.33631059
11	MAP3K4	2.24312297
12	MAP2K7	2.23339962
13	NEK1	2.08726597
14	TAOK3	2.05782875
15	BMPR1B	1.99451867
16	TRIM28	1.91527988
17	INSRR	1.81565987
18	CASK	1.63455423
19	CCNB1	1.58102197
20	VRK1	1.49613805
21	DYRK3	1.44318931
22	MARK1	1.37558516
23	FLT3	1.35754997
24	CSNK1G3	1.29736243
25	MKNK1	1.25601078
26	EIF2AK3	1.24642056
27	NEK2	1.24444828
28	GRK1	1.18152185
29	CSNK1G1	1.15838869
30	CSNK1A1L	1.15294982
31	DYRK2	1.13404222
32	CSNK1G2	1.12456755
33	TAF1	1.12222149
34	ADRBK1	1.09320239
35	PLK2	1.08998130
36	PLK4	1.04228705
37	WEE1	0.98265503
38	MAPKAPK5	0.92634257
39	PRKCE	0.91969254
40	PNCK	0.90048984
41	PBK	0.86218834
42	ATR	0.82885273
43	TGFBR1	0.82120684
44	BCR	0.80347979
45	TLK1	0.80280544
46	STK38L	0.79858355
47	MKNK2	0.78452349
48	PRKCG	0.75617774
49	PLK3	0.74041840
50	PKN1	0.73834615
51	EPHA4	0.73466946
52	RPS6KA4	0.72205537
53	BRSK2	0.71565417
54	ACVR1B	0.71324096
55	SRPK1	0.70312212
56	RPS6KA5	0.70018570
57	TNK2	0.69825154
58	FER	0.67867515
59	PIM2	0.67610259
60	PAK3	0.67517030
61	KIT	0.67375675
62	CDK3	0.65635352
63	MARK3	0.65626168
64	CDC7	0.63785554
65	TEC	0.61752635
66	ERBB3	0.59668151
67	PLK1	0.58715908
68	TNIK	0.57228844
69	WNK4	0.54954620
70	OXSR1	0.54187664
71	DYRK1A	0.53534034
72	CSNK1A1	0.50681187
73	CHEK2	0.50006442
74	STK39	0.49580969
75	MAP2K4	0.48895512
76	ATM	0.48034161
77	PDK2	0.45025543
78	IRAK1	0.44941146
79	MAPKAPK3	0.44542050
80	CAMK2A	0.43791974
81	NTRK2	0.39150222
82	CLK1	0.38415457
83	TIE1	0.37384787
84	CAMK1	0.37372018
85	PTK2B	0.35424606
86	PIK3CA	0.34562079
87	BRD4	0.33663129
88	PRKACA	0.32443637
89	KDR	0.30484172
90	CSNK2A1	0.30258062
91	AURKB	0.29960509
92	TTK	0.29530796
93	AKT3	0.29140917
94	CSNK2A2	0.28940249
95	GRK5	0.28884375
96	STK16	0.28436022
97	PRKCI	0.28134023
98	CSNK1D	0.26662377
99	PRKACB	0.26615686
100	EIF2AK2	0.25490285

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.13993731
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.91412792
3	Butanoate metabolism_Homo sapiens_hsa00650	2.91351282
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.84942361
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.77121668
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.50574914
7	Homologous recombination_Homo sapiens_hsa03440	2.50536506
8	Phototransduction_Homo sapiens_hsa04744	2.37086444
9	Propanoate metabolism_Homo sapiens_hsa00640	2.30105417
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.21988782
11	Base excision repair_Homo sapiens_hsa03410	2.20754004
12	RNA polymerase_Homo sapiens_hsa03020	1.99242905
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97939819
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.82909985
15	Basal transcription factors_Homo sapiens_hsa03022	1.74033276
16	Peroxisome_Homo sapiens_hsa04146	1.69131514
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.67035779
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.63485724
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.62315077
20	Olfactory transduction_Homo sapiens_hsa04740	1.57827268
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56757882
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.54992183
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53461965
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47210151
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43008711
26	Parkinsons disease_Homo sapiens_hsa05012	1.42954558
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37891206
28	RNA degradation_Homo sapiens_hsa03018	1.35328924
29	DNA replication_Homo sapiens_hsa03030	1.30015073
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27096093
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.26632830
32	Mismatch repair_Homo sapiens_hsa03430	1.25914755
33	Protein export_Homo sapiens_hsa03060	1.25688005
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24914627
35	Taste transduction_Homo sapiens_hsa04742	1.24784492
36	Purine metabolism_Homo sapiens_hsa00230	1.24283744
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21781533
38	Caffeine metabolism_Homo sapiens_hsa00232	1.20332219
39	Fatty acid elongation_Homo sapiens_hsa00062	1.18950196
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18768832
41	One carbon pool by folate_Homo sapiens_hsa00670	1.17903178
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17898737
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.17542196
44	Nicotine addiction_Homo sapiens_hsa05033	1.12490796
45	ABC transporters_Homo sapiens_hsa02010	1.12011863
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07837968
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.07328384
48	Huntingtons disease_Homo sapiens_hsa05016	1.06006403
49	Fatty acid degradation_Homo sapiens_hsa00071	1.04420791
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03971491
51	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02941788
52	Proteasome_Homo sapiens_hsa03050	1.01153202
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00118887
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98569105
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98548657
56	Glutathione metabolism_Homo sapiens_hsa00480	0.97965509
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.95909545
58	Regulation of autophagy_Homo sapiens_hsa04140	0.95830921
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91385521
60	Metabolic pathways_Homo sapiens_hsa01100	0.90095478
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88926917
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79265561
63	RNA transport_Homo sapiens_hsa03013	0.79167108
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71761398
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66290729
66	Retinol metabolism_Homo sapiens_hsa00830	0.65504087
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60395320
68	Alzheimers disease_Homo sapiens_hsa05010	0.59704180
69	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59427070
70	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56676307
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.55118377
72	Carbon metabolism_Homo sapiens_hsa01200	0.55103442
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53964023
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.50880230
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50232876
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49548676
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49374152
78	Lysine degradation_Homo sapiens_hsa00310	0.49204320
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48980750
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.48139449
81	Spliceosome_Homo sapiens_hsa03040	0.46799160
82	Morphine addiction_Homo sapiens_hsa05032	0.46352539
83	Asthma_Homo sapiens_hsa05310	0.45522148
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45430564
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.45280243
86	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45174562
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44383752
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44267098
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43332759
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42385844
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39678916
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.39632803
93	Salivary secretion_Homo sapiens_hsa04970	0.38676488
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38146631
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36858489
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34792739
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34780079
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34185838
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33326649
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32723057

SPDYE8P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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