SPDYE9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.60717318
2negative regulation of cytosolic calcium ion concentration (GO:0051481)5.11835447
3regulation of cilium movement (GO:0003352)4.80847399
4piRNA metabolic process (GO:0034587)4.35399051
5behavioral response to ethanol (GO:0048149)4.05267159
6epithelial cilium movement (GO:0003351)3.92626409
7protein polyglutamylation (GO:0018095)3.89095828
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79377885
9nonmotile primary cilium assembly (GO:0035058)3.71898279
10centriole replication (GO:0007099)3.66261467
11ubiquinone biosynthetic process (GO:0006744)3.64219780
12axoneme assembly (GO:0035082)3.63203733
13sperm motility (GO:0030317)3.58936356
14intraciliary transport (GO:0042073)3.57745193
15DNA deamination (GO:0045006)3.57061108
16photoreceptor cell maintenance (GO:0045494)3.53792935
17platelet dense granule organization (GO:0060155)3.47681250
18cellular ketone body metabolic process (GO:0046950)3.44704108
19DNA double-strand break processing (GO:0000729)3.42220370
20neural tube formation (GO:0001841)3.40795443
21GPI anchor metabolic process (GO:0006505)3.36201378
22ubiquinone metabolic process (GO:0006743)3.32560226
23replication fork processing (GO:0031297)3.31390766
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30650263
25respiratory chain complex IV assembly (GO:0008535)3.24611720
26protein complex biogenesis (GO:0070271)3.24274289
27cilium movement (GO:0003341)3.22769150
28cilium or flagellum-dependent cell motility (GO:0001539)3.22400015
29indolalkylamine metabolic process (GO:0006586)3.21855487
30seminiferous tubule development (GO:0072520)3.21702930
31retinal cone cell development (GO:0046549)3.21508784
32preassembly of GPI anchor in ER membrane (GO:0016254)3.20358966
33detection of light stimulus involved in sensory perception (GO:0050962)3.18889274
34detection of light stimulus involved in visual perception (GO:0050908)3.18889274
35mitochondrial respiratory chain complex assembly (GO:0033108)3.16354672
36quinone biosynthetic process (GO:1901663)3.15291710
37ketone body metabolic process (GO:1902224)3.11243341
38cytochrome complex assembly (GO:0017004)3.10866226
39cilium morphogenesis (GO:0060271)3.09361084
40regulation of microtubule-based movement (GO:0060632)3.09029620
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05598902
42opioid receptor signaling pathway (GO:0038003)3.05546258
43cilium organization (GO:0044782)3.05285846
44microtubule severing (GO:0051013)3.05173791
45L-fucose catabolic process (GO:0042355)3.02367326
46fucose catabolic process (GO:0019317)3.02367326
47L-fucose metabolic process (GO:0042354)3.02367326
48cilium assembly (GO:0042384)3.01756394
49acrosome reaction (GO:0007340)3.01201648
50negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.00961176
51mitochondrial respiratory chain complex I assembly (GO:0032981)2.99602160
52NADH dehydrogenase complex assembly (GO:0010257)2.99602160
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99602160
54GPI anchor biosynthetic process (GO:0006506)2.98667423
55spermatid development (GO:0007286)2.96027330
56tryptophan catabolic process (GO:0006569)2.93912521
57indole-containing compound catabolic process (GO:0042436)2.93912521
58indolalkylamine catabolic process (GO:0046218)2.93912521
59microtubule depolymerization (GO:0007019)2.93859097
60C4-dicarboxylate transport (GO:0015740)2.90528795
61mannosylation (GO:0097502)2.88389317
62gamma-aminobutyric acid transport (GO:0015812)2.86565670
63microtubule polymerization or depolymerization (GO:0031109)2.85407222
64ether lipid metabolic process (GO:0046485)2.85224350
65adult feeding behavior (GO:0008343)2.82757325
66behavioral response to nicotine (GO:0035095)2.82522398
67DNA integration (GO:0015074)2.81370203
68histone mRNA catabolic process (GO:0071044)2.79194009
69tachykinin receptor signaling pathway (GO:0007217)2.78634939
70tryptophan metabolic process (GO:0006568)2.76283008
71cornea development in camera-type eye (GO:0061303)2.75152179
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73714821
73anterograde synaptic vesicle transport (GO:0048490)2.72793999
74recombinational repair (GO:0000725)2.71958949
75photoreceptor cell development (GO:0042461)2.71909692
76DNA methylation involved in gamete generation (GO:0043046)2.70997777
77multicellular organism reproduction (GO:0032504)2.70863307
78double-strand break repair via homologous recombination (GO:0000724)2.70233524
79resolution of meiotic recombination intermediates (GO:0000712)2.70169712
80negative regulation of cAMP-mediated signaling (GO:0043951)2.64801038
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64564696
82mismatch repair (GO:0006298)2.64544699
83neuronal action potential (GO:0019228)2.64302812
84negative regulation of telomere maintenance (GO:0032205)2.64118706
85estrogen biosynthetic process (GO:0006703)2.63369872
86water-soluble vitamin biosynthetic process (GO:0042364)2.61905477
87positive regulation of mitochondrial fission (GO:0090141)2.60842084
88branched-chain amino acid catabolic process (GO:0009083)2.60783153
89ncRNA catabolic process (GO:0034661)2.59988508
90glycolipid biosynthetic process (GO:0009247)2.59694819
91GMP metabolic process (GO:0046037)2.56769067
92regulation of meiosis I (GO:0060631)2.55700615
93single strand break repair (GO:0000012)2.53822001
94positive regulation of developmental pigmentation (GO:0048087)2.53766798
95amine catabolic process (GO:0009310)2.53629288
96cellular biogenic amine catabolic process (GO:0042402)2.53629288
97regulation of telomere maintenance (GO:0032204)2.53256229
98C-terminal protein lipidation (GO:0006501)2.51525696
99glycerol ether metabolic process (GO:0006662)2.49102586
100pyrimidine nucleobase catabolic process (GO:0006208)2.48882634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.83219213
2IGF1R_20145208_ChIP-Seq_DFB_Human3.17532246
3GBX2_23144817_ChIP-Seq_PC3_Human3.12469909
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07000920
5VDR_22108803_ChIP-Seq_LS180_Human2.85509141
6TAF15_26573619_Chip-Seq_HEK293_Human2.85486493
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56406018
8EZH2_22144423_ChIP-Seq_EOC_Human2.51507674
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44563368
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40456827
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37759035
12FUS_26573619_Chip-Seq_HEK293_Human2.35356995
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24360266
14EWS_26573619_Chip-Seq_HEK293_Human2.14465642
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.14273311
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09362592
17P300_19829295_ChIP-Seq_ESCs_Human2.01457175
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00063668
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.96037357
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.88577478
21CBP_20019798_ChIP-Seq_JUKART_Human1.88577478
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.88394608
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85732152
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.83256549
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81835019
26ER_23166858_ChIP-Seq_MCF-7_Human1.81047443
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78759354
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78759354
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67697562
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63439722
31IRF1_19129219_ChIP-ChIP_H3396_Human1.60376121
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58690237
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57642228
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54006618
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51330309
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51271022
37STAT3_23295773_ChIP-Seq_U87_Human1.48779239
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48730945
39TP53_22573176_ChIP-Seq_HFKS_Human1.48352500
40SMAD4_21799915_ChIP-Seq_A2780_Human1.47676971
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46728870
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45817835
43SOX2_19829295_ChIP-Seq_ESCs_Human1.45031343
44NANOG_19829295_ChIP-Seq_ESCs_Human1.45031343
45TCF4_23295773_ChIP-Seq_U87_Human1.40909490
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37197323
47AR_25329375_ChIP-Seq_VCAP_Human1.35854354
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33252242
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32942144
50MYC_18940864_ChIP-ChIP_HL60_Human1.32558748
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.31114535
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30851643
53VDR_23849224_ChIP-Seq_CD4+_Human1.30442881
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28623492
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26923311
56ELK1_19687146_ChIP-ChIP_HELA_Human1.26157436
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25626859
58BCAT_22108803_ChIP-Seq_LS180_Human1.25584002
59RUNX2_22187159_ChIP-Seq_PCA_Human1.23918012
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.23547870
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.23287025
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.21846256
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.19892125
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.19513793
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19513793
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.17945035
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17639103
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16819143
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15448982
70TCF4_22108803_ChIP-Seq_LS180_Human1.14908501
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13463237
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13374231
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.13301321
74RNF2_27304074_Chip-Seq_NSC_Mouse1.13183235
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.10642818
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08941869
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08894658
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06939560
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06764637
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.05724000
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05207230
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04997551
83REST_21632747_ChIP-Seq_MESCs_Mouse1.04504193
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04315564
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.02680516
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.01850930
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01348289
88NCOR_22424771_ChIP-Seq_293T_Human1.01229859
89FOXP3_21729870_ChIP-Seq_TREG_Human1.01063402
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00231360
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.99956430
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99891308
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98545914
94HOXB7_26014856_ChIP-Seq_BT474_Human0.98089574
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.98028429
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97650724
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.96553795
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95854133
99P53_22387025_ChIP-Seq_ESCs_Mouse0.95823632
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.95323066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.00599819
2MP0001968_abnormal_touch/_nociception2.93084187
3MP0005551_abnormal_eye_electrophysiolog2.67088482
4MP0008877_abnormal_DNA_methylation2.62957871
5MP0002102_abnormal_ear_morphology2.23168121
6MP0006292_abnormal_olfactory_placode2.14223092
7MP0003136_yellow_coat_color2.06072063
8MP0005410_abnormal_fertilization2.03065988
9MP0003787_abnormal_imprinting1.98624179
10MP0008058_abnormal_DNA_repair1.98198688
11MP0002638_abnormal_pupillary_reflex1.95793004
12MP0001486_abnormal_startle_reflex1.92739022
13MP0002876_abnormal_thyroid_physiology1.92523017
14MP0000015_abnormal_ear_pigmentation1.89232583
15MP0002736_abnormal_nociception_after1.85772097
16MP0000372_irregular_coat_pigmentation1.83604533
17MP0005645_abnormal_hypothalamus_physiol1.81629675
18MP0005646_abnormal_pituitary_gland1.77933786
19MP0002735_abnormal_chemical_nociception1.75261677
20MP0001986_abnormal_taste_sensitivity1.74676750
21MP0005423_abnormal_somatic_nervous1.73246900
22MP0006276_abnormal_autonomic_nervous1.73224452
23MP0006072_abnormal_retinal_apoptosis1.73055402
24MP0001529_abnormal_vocalization1.66945114
25MP0005253_abnormal_eye_physiology1.66705116
26MP0003718_maternal_effect1.63165096
27MP0009745_abnormal_behavioral_response1.60373371
28MP0008789_abnormal_olfactory_epithelium1.60228311
29MP0000569_abnormal_digit_pigmentation1.58793492
30MP0009278_abnormal_bone_marrow1.57855289
31MP0002653_abnormal_ependyma_morphology1.57571282
32MP0001984_abnormal_olfaction1.57043446
33MP0008872_abnormal_physiological_respon1.55631466
34MP0009046_muscle_twitch1.51722041
35MP0002272_abnormal_nervous_system1.50300324
36MP0008995_early_reproductive_senescence1.49049390
37MP0002234_abnormal_pharynx_morphology1.48902229
38MP0001501_abnormal_sleep_pattern1.44349264
39MP0008875_abnormal_xenobiotic_pharmacok1.42921992
40MP0006035_abnormal_mitochondrial_morpho1.41815236
41MP0003195_calcinosis1.38726388
42MP0003698_abnormal_male_reproductive1.38700765
43MP0002095_abnormal_skin_pigmentation1.38184149
44MP0005075_abnormal_melanosome_morpholog1.37868249
45MP0010386_abnormal_urinary_bladder1.35378488
46MP0004147_increased_porphyrin_level1.35009350
47MP0004043_abnormal_pH_regulation1.33912846
48MP0002938_white_spotting1.33205084
49MP0005499_abnormal_olfactory_system1.30556387
50MP0005394_taste/olfaction_phenotype1.30556387
51MP0001929_abnormal_gametogenesis1.30234302
52MP0001485_abnormal_pinna_reflex1.25567470
53MP0003646_muscle_fatigue1.24811916
54MP0002837_dystrophic_cardiac_calcinosis1.21929671
55MP0001764_abnormal_homeostasis1.21508554
56MP0003121_genomic_imprinting1.19659298
57MP0002572_abnormal_emotion/affect_behav1.19267203
58MP0001970_abnormal_pain_threshold1.19139230
59MP0002733_abnormal_thermal_nociception1.17163755
60MP0001324_abnormal_eye_pigmentation1.15875121
61MP0002067_abnormal_sensory_capabilities1.13504742
62MP0000778_abnormal_nervous_system1.12257234
63MP0005174_abnormal_tail_pigmentation1.10879273
64MP0000631_abnormal_neuroendocrine_gland1.08767830
65MP0003122_maternal_imprinting1.08517046
66MP0001905_abnormal_dopamine_level1.08215586
67MP0002064_seizures1.07071686
68MP0003011_delayed_dark_adaptation1.06838872
69MP0005084_abnormal_gallbladder_morpholo1.06502296
70MP0002160_abnormal_reproductive_system1.05815057
71MP0002557_abnormal_social/conspecific_i1.05613702
72MP0003635_abnormal_synaptic_transmissio1.04810587
73MP0004133_heterotaxia1.04573607
74MP0005171_absent_coat_pigmentation1.03569510
75MP0001963_abnormal_hearing_physiology1.03113264
76MP0004742_abnormal_vestibular_system1.02850011
77MP0004142_abnormal_muscle_tone1.01109991
78MP0010094_abnormal_chromosome_stability1.00451626
79MP0002751_abnormal_autonomic_nervous1.00197848
80MP0000516_abnormal_urinary_system0.98714217
81MP0005367_renal/urinary_system_phenotyp0.98714217
82MP0005377_hearing/vestibular/ear_phenot0.97956606
83MP0003878_abnormal_ear_physiology0.97956606
84MP0009764_decreased_sensitivity_to0.97110586
85MP0005195_abnormal_posterior_eye0.96906825
86MP0002752_abnormal_somatic_nervous0.94027633
87MP0002734_abnormal_mechanical_nocicepti0.89877632
88MP0006036_abnormal_mitochondrial_physio0.89693862
89MP0000566_synostosis0.87792389
90MP0002282_abnormal_trachea_morphology0.86251627
91MP0002210_abnormal_sex_determination0.85935634
92MP0002229_neurodegeneration0.85219229
93MP0005397_hematopoietic_system_phenotyp0.84557234
94MP0001545_abnormal_hematopoietic_system0.84557234
95MP0004859_abnormal_synaptic_plasticity0.84247430
96MP0003567_abnormal_fetal_cardiomyocyte0.83478000
97MP0000653_abnormal_sex_gland0.82367253
98MP0000026_abnormal_inner_ear0.81090104
99MP0002822_catalepsy0.79788943
100MP0002063_abnormal_learning/memory/cond0.79712050

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.17503409
2Pancreatic fibrosis (HP:0100732)4.16489318
3True hermaphroditism (HP:0010459)4.04001830
4Thyroid-stimulating hormone excess (HP:0002925)3.73634769
5Medial flaring of the eyebrow (HP:0010747)3.61919767
6Abnormality of midbrain morphology (HP:0002418)3.56685347
7Molar tooth sign on MRI (HP:0002419)3.56685347
8Nephronophthisis (HP:0000090)3.48104039
9Gait imbalance (HP:0002141)3.18370454
10Congenital primary aphakia (HP:0007707)3.14291199
11Nephrogenic diabetes insipidus (HP:0009806)3.02911832
12Abnormality of the renal medulla (HP:0100957)2.92904864
13Focal motor seizures (HP:0011153)2.90841416
14Aplasia/Hypoplasia of the tibia (HP:0005772)2.86110695
15Congenital stationary night blindness (HP:0007642)2.84535631
16Attenuation of retinal blood vessels (HP:0007843)2.82925881
17Intestinal atresia (HP:0011100)2.73457189
18Cystic liver disease (HP:0006706)2.73106093
19Progressive inability to walk (HP:0002505)2.72565771
20Genital tract atresia (HP:0001827)2.70187623
21Volvulus (HP:0002580)2.65547143
22Hepatocellular necrosis (HP:0001404)2.62135099
23Abnormality of the renal cortex (HP:0011035)2.61909718
24Hyperventilation (HP:0002883)2.59123498
25Abnormality of macular pigmentation (HP:0008002)2.58994860
26Gaze-evoked nystagmus (HP:0000640)2.58246781
27Chronic hepatic failure (HP:0100626)2.57326688
28Tubulointerstitial nephritis (HP:0001970)2.57042140
29Vaginal atresia (HP:0000148)2.55980431
30Inability to walk (HP:0002540)2.55858833
31Abnormal rod and cone electroretinograms (HP:0008323)2.55610679
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.55608212
33Renal cortical cysts (HP:0000803)2.54692866
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.41932555
35Absent/shortened dynein arms (HP:0200106)2.41932555
36Hepatic necrosis (HP:0002605)2.39840659
37Postaxial foot polydactyly (HP:0001830)2.38360779
38Short tibia (HP:0005736)2.37965653
39Mitochondrial inheritance (HP:0001427)2.31837721
40Severe visual impairment (HP:0001141)2.30838000
41Abnormality of the labia minora (HP:0012880)2.30792504
42Increased CSF lactate (HP:0002490)2.28275850
43Abnormality of the ileum (HP:0001549)2.27701594
44Congenital hepatic fibrosis (HP:0002612)2.27196198
45Anencephaly (HP:0002323)2.21897714
46Broad-based gait (HP:0002136)2.21003116
47Abolished electroretinogram (ERG) (HP:0000550)2.20584206
48Poor coordination (HP:0002370)2.20151843
49Sclerocornea (HP:0000647)2.18129329
50Abnormal respiratory epithelium morphology (HP:0012253)2.17879706
51Abnormal respiratory motile cilium morphology (HP:0005938)2.17879706
52Bony spicule pigmentary retinopathy (HP:0007737)2.17036026
53Abnormal ciliary motility (HP:0012262)2.15754524
54Colon cancer (HP:0003003)2.15478093
55Type II lissencephaly (HP:0007260)2.14377407
56Lissencephaly (HP:0001339)2.13107819
57Hyperglycinemia (HP:0002154)2.12910088
58Optic nerve hypoplasia (HP:0000609)2.11524729
59Absent speech (HP:0001344)2.11274797
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.10002606
61Pendular nystagmus (HP:0012043)2.09371275
62Astigmatism (HP:0000483)2.07984911
63Retinitis pigmentosa (HP:0000510)2.07572814
64Decreased central vision (HP:0007663)2.05891574
65Hyperglycinuria (HP:0003108)2.03133827
66Methylmalonic acidemia (HP:0002912)2.01572856
67Male pseudohermaphroditism (HP:0000037)2.01242516
68Large for gestational age (HP:0001520)2.00079812
69Sloping forehead (HP:0000340)2.00041925
70Focal seizures (HP:0007359)1.99759515
71Acute encephalopathy (HP:0006846)1.98229029
72Abnormal biliary tract physiology (HP:0012439)1.97972376
73Bile duct proliferation (HP:0001408)1.97972376
74Postaxial hand polydactyly (HP:0001162)1.97884908
75Preaxial hand polydactyly (HP:0001177)1.97877892
76Acute necrotizing encephalopathy (HP:0006965)1.95536754
77Cerebellar dysplasia (HP:0007033)1.93832387
78Dialeptic seizures (HP:0011146)1.93270173
79Tubular atrophy (HP:0000092)1.93062570
80Atonic seizures (HP:0010819)1.91794133
81Keratoconus (HP:0000563)1.89915910
82Increased corneal curvature (HP:0100692)1.89915910
83Progressive cerebellar ataxia (HP:0002073)1.88780426
84Pancreatic islet-cell hyperplasia (HP:0004510)1.86598342
85Aganglionic megacolon (HP:0002251)1.85620367
86Lipid accumulation in hepatocytes (HP:0006561)1.84570716
87Meckel diverticulum (HP:0002245)1.84547449
88Hypothermia (HP:0002045)1.84530094
89Clubbing of toes (HP:0100760)1.83776265
90Polydipsia (HP:0001959)1.83112808
91Abnormal drinking behavior (HP:0030082)1.83112808
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82680672
93Increased hepatocellular lipid droplets (HP:0006565)1.81533843
94Optic disc pallor (HP:0000543)1.81382190
95Abnormality of glycine metabolism (HP:0010895)1.80335659
96Abnormality of serine family amino acid metabolism (HP:0010894)1.80335659
97Occipital encephalocele (HP:0002085)1.80152040
98Broad foot (HP:0001769)1.79932696
99Tubulointerstitial abnormality (HP:0001969)1.78438283
100Methylmalonic aciduria (HP:0012120)1.78279969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86369245
2MAP4K24.19397284
3ADRBK23.08404144
4WNK32.96244983
5NUAK12.66687047
6MAPK132.51447638
7MAP3K42.41293026
8INSRR2.34933709
9BCKDK2.30101115
10BMPR1B2.16768250
11CASK2.09176769
12ZAK1.99200895
13MAP2K71.98449542
14PLK41.98206793
15TRIM281.94122521
16NEK11.92430582
17VRK21.78517557
18PINK11.78048491
19MARK11.72681530
20TAOK31.56766381
21PLK21.53566970
22EIF2AK31.42118079
23CSNK1G31.34057868
24CSNK1G21.24518928
25VRK11.21153203
26CSNK1A1L1.20802511
27CCNB11.18568134
28PNCK1.16553604
29ACVR1B1.16378990
30GRK11.16025238
31CSNK1G11.13898999
32MKNK11.13560440
33MKNK21.09702393
34WEE11.09322414
35BRSK21.07038950
36ADRBK11.04460406
37BCR1.03589111
38TNIK1.02867184
39PRKCE1.02434468
40DYRK20.94800528
41STK390.93870444
42STK38L0.93854732
43PRKCG0.89980810
44PAK30.87767570
45FLT30.87176496
46MAPKAPK50.86353530
47PLK30.85980426
48TGFBR10.81514571
49DYRK30.80331648
50OXSR10.77884843
51EPHA40.76852367
52PKN10.70674879
53MAPKAPK30.68704952
54NEK20.68118532
55SRPK10.66254335
56ERBB30.65902794
57FER0.65675621
58TLK10.63495796
59ATR0.62183664
60CDC70.61717314
61PDK20.61496931
62CDK30.61463797
63WNK40.60876682
64RPS6KA40.58359383
65AKT30.58040107
66PIK3CA0.57045973
67CAMK2A0.55947483
68TIE10.54708048
69PLK10.54255464
70NTRK20.52410609
71TAF10.52035229
72STK160.51908344
73IRAK10.49384570
74PIM20.47484894
75CHEK20.47314222
76TEC0.45325372
77CSNK1A10.45274873
78ATM0.44439768
79MAP2K40.43758676
80TNK20.41563406
81EIF2AK20.40687929
82MST40.40034134
83PTK2B0.39767577
84PRKACA0.38054535
85SIK20.37881783
86PRKCQ0.37875152
87KIT0.37041634
88BRD40.35727896
89DYRK1A0.35216877
90MAPK150.34611521
91IKBKB0.32234193
92CSNK1D0.32157380
93GRK50.30729335
94CAMK10.30603375
95RPS6KA50.29388737
96PRKG10.28232104
97CSNK2A10.26678514
98MARK30.26597170
99MINK10.26077946
100NTRK30.26048179

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.81954200
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.09285375
3Butanoate metabolism_Homo sapiens_hsa006503.06419774
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.91341195
5Fanconi anemia pathway_Homo sapiens_hsa034602.84303113
6Phototransduction_Homo sapiens_hsa047442.53413570
7Homologous recombination_Homo sapiens_hsa034402.39418682
8Propanoate metabolism_Homo sapiens_hsa006402.38296284
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32499344
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16187204
11Protein export_Homo sapiens_hsa030601.99316030
12Basal transcription factors_Homo sapiens_hsa030221.97142480
13RNA polymerase_Homo sapiens_hsa030201.71552746
14Olfactory transduction_Homo sapiens_hsa047401.69810811
15Linoleic acid metabolism_Homo sapiens_hsa005911.68530639
16Non-homologous end-joining_Homo sapiens_hsa034501.68366913
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68096032
18Nicotine addiction_Homo sapiens_hsa050331.67068433
19Nitrogen metabolism_Homo sapiens_hsa009101.62866001
20Peroxisome_Homo sapiens_hsa041461.62541538
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59571386
22Oxidative phosphorylation_Homo sapiens_hsa001901.58525592
23Base excision repair_Homo sapiens_hsa034101.57714537
24RNA degradation_Homo sapiens_hsa030181.54436460
25Taste transduction_Homo sapiens_hsa047421.54094572
26Tryptophan metabolism_Homo sapiens_hsa003801.52986932
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.49538211
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49088745
29Selenocompound metabolism_Homo sapiens_hsa004501.46771510
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45299979
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40318934
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.37030343
33Parkinsons disease_Homo sapiens_hsa050121.35026755
34Proteasome_Homo sapiens_hsa030501.35022080
35Caffeine metabolism_Homo sapiens_hsa002321.30857206
36ABC transporters_Homo sapiens_hsa020101.18055531
37Regulation of autophagy_Homo sapiens_hsa041401.17425857
38Ether lipid metabolism_Homo sapiens_hsa005651.16476922
39Huntingtons disease_Homo sapiens_hsa050161.13526830
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11452010
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09426814
42Purine metabolism_Homo sapiens_hsa002301.04258564
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02836996
44Dorso-ventral axis formation_Homo sapiens_hsa043201.01473286
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98685878
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96631303
47Chemical carcinogenesis_Homo sapiens_hsa052040.92513700
48Fatty acid degradation_Homo sapiens_hsa000710.92222113
49Fatty acid metabolism_Homo sapiens_hsa012120.90425243
50Nucleotide excision repair_Homo sapiens_hsa034200.88729876
51One carbon pool by folate_Homo sapiens_hsa006700.86257861
52RNA transport_Homo sapiens_hsa030130.86013501
53Pyrimidine metabolism_Homo sapiens_hsa002400.84183424
54Fatty acid elongation_Homo sapiens_hsa000620.83734030
55Metabolic pathways_Homo sapiens_hsa011000.83242362
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82395375
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82233566
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81570235
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.77755616
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75919898
61Steroid biosynthesis_Homo sapiens_hsa001000.75025182
62Morphine addiction_Homo sapiens_hsa050320.74702110
63Retinol metabolism_Homo sapiens_hsa008300.74607098
64Mismatch repair_Homo sapiens_hsa034300.73987461
65Glycerolipid metabolism_Homo sapiens_hsa005610.70872283
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70339328
67Arachidonic acid metabolism_Homo sapiens_hsa005900.69598134
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66560397
69Alzheimers disease_Homo sapiens_hsa050100.65821188
70beta-Alanine metabolism_Homo sapiens_hsa004100.61212391
71Glutathione metabolism_Homo sapiens_hsa004800.60538790
72Primary immunodeficiency_Homo sapiens_hsa053400.59841460
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57336521
74Salivary secretion_Homo sapiens_hsa049700.56986431
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.56688748
76Circadian entrainment_Homo sapiens_hsa047130.56001248
77GABAergic synapse_Homo sapiens_hsa047270.54105686
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53691011
79Glutamatergic synapse_Homo sapiens_hsa047240.53298031
80Collecting duct acid secretion_Homo sapiens_hsa049660.51528679
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.51011318
82Cardiac muscle contraction_Homo sapiens_hsa042600.49904029
83Calcium signaling pathway_Homo sapiens_hsa040200.46066160
84Sphingolipid metabolism_Homo sapiens_hsa006000.43559345
85Serotonergic synapse_Homo sapiens_hsa047260.42452275
86Ovarian steroidogenesis_Homo sapiens_hsa049130.40865613
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39591852
88Pyruvate metabolism_Homo sapiens_hsa006200.38054734
89Oocyte meiosis_Homo sapiens_hsa041140.36762615
90Sulfur relay system_Homo sapiens_hsa041220.36159419
91Lysine degradation_Homo sapiens_hsa003100.34794943
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.33742569
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.32891437
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32680985
95Fat digestion and absorption_Homo sapiens_hsa049750.31350605
96Spliceosome_Homo sapiens_hsa030400.30417318
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30159872
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29601144
99DNA replication_Homo sapiens_hsa030300.29196831
100Arginine and proline metabolism_Homo sapiens_hsa003300.27443479

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