SPECC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)5.11900226
2axon ensheathment in central nervous system (GO:0032291)4.81050770
3central nervous system myelination (GO:0022010)4.81050770
4amino acid import (GO:0043090)4.27430041
5protoporphyrinogen IX metabolic process (GO:0046501)4.26846479
6response to methylmercury (GO:0051597)4.26563479
7locomotory exploration behavior (GO:0035641)4.08367488
8cytoskeletal anchoring at plasma membrane (GO:0007016)4.04326290
9presynaptic membrane assembly (GO:0097105)3.96682016
10axon ensheathment (GO:0008366)3.81860616
11ensheathment of neurons (GO:0007272)3.81860616
12myelination (GO:0042552)3.79227105
13postsynaptic membrane organization (GO:0001941)3.67770065
14negative regulation of neurotransmitter secretion (GO:0046929)3.65539180
15regulation of hippo signaling (GO:0035330)3.63355455
16protein polyglutamylation (GO:0018095)3.61798781
17regulation of gene silencing by RNA (GO:0060966)3.59677108
18regulation of posttranscriptional gene silencing (GO:0060147)3.59677108
19regulation of gene silencing by miRNA (GO:0060964)3.59677108
20protoporphyrinogen IX biosynthetic process (GO:0006782)3.59261470
21negative regulation of neurotransmitter transport (GO:0051589)3.54192250
22cAMP catabolic process (GO:0006198)3.53759311
23import into cell (GO:0098657)3.53161038
24phosphorelay signal transduction system (GO:0000160)3.50413916
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.49735635
26protein K11-linked deubiquitination (GO:0035871)3.47303736
27cyclic nucleotide catabolic process (GO:0009214)3.43878628
28regulation of neurotransmitter uptake (GO:0051580)3.41271140
29synaptic vesicle maturation (GO:0016188)3.35534516
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34818578
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.34818578
32regulation of translation, ncRNA-mediated (GO:0045974)3.34818578
33cerebellar granule cell differentiation (GO:0021707)3.25389977
34establishment of protein localization to Golgi (GO:0072600)3.21847438
35protein localization to endosome (GO:0036010)3.21125456
36microtubule anchoring (GO:0034453)3.19289549
37neurotransmitter uptake (GO:0001504)3.16864848
38serotonin metabolic process (GO:0042428)3.13568826
39neuronal action potential propagation (GO:0019227)3.11286054
40negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.10803216
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09256896
42nerve growth factor signaling pathway (GO:0038180)3.08965318
43regulation of response to osmotic stress (GO:0047484)3.08496840
44protein K48-linked deubiquitination (GO:0071108)3.06521393
45peripheral nervous system axon ensheathment (GO:0032292)3.05059124
46myelination in peripheral nervous system (GO:0022011)3.05059124
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04166164
48cortical actin cytoskeleton organization (GO:0030866)3.03697892
49glutamate receptor signaling pathway (GO:0007215)3.03158021
50cellular potassium ion homeostasis (GO:0030007)2.98727750
51regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96228512
52interkinetic nuclear migration (GO:0022027)2.95910661
53glycine transport (GO:0015816)2.93789043
54adult walking behavior (GO:0007628)2.91688062
55dendrite morphogenesis (GO:0048813)2.89795019
56behavioral response to nicotine (GO:0035095)2.87069751
57primary amino compound metabolic process (GO:1901160)2.86821087
58long-chain fatty acid biosynthetic process (GO:0042759)2.86774476
59pyrimidine nucleobase catabolic process (GO:0006208)2.85497725
60positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.85399249
61vocalization behavior (GO:0071625)2.83884935
62piRNA metabolic process (GO:0034587)2.81974965
63transmission of nerve impulse (GO:0019226)2.81549369
64centriole replication (GO:0007099)2.80707468
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.80539576
66ovulation cycle (GO:0042698)2.77599400
67gamma-aminobutyric acid signaling pathway (GO:0007214)2.77280452
68regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.77064742
69cortical cytoskeleton organization (GO:0030865)2.76106378
70C4-dicarboxylate transport (GO:0015740)2.75588502
71regulation of ARF GTPase activity (GO:0032312)2.75111875
72cerebellar Purkinje cell differentiation (GO:0021702)2.73845619
73regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73842490
74cellular response to sterol (GO:0036315)2.73540204
75retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72876332
76DNA methylation involved in gamete generation (GO:0043046)2.71702286
77sodium ion export (GO:0071436)2.70702093
78protein targeting to Golgi (GO:0000042)2.70544044
79neuron cell-cell adhesion (GO:0007158)2.69967842
80retinal cone cell development (GO:0046549)2.69805196
81protein prenylation (GO:0018342)2.69453811
82prenylation (GO:0097354)2.69453811
83gamma-aminobutyric acid transport (GO:0015812)2.68475018
84neural tube formation (GO:0001841)2.68388063
85neuronal ion channel clustering (GO:0045161)2.67797889
86semaphorin-plexin signaling pathway (GO:0071526)2.67517084
87synaptic vesicle endocytosis (GO:0048488)2.65760258
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.64808225
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64808225
90protein localization to Golgi apparatus (GO:0034067)2.64740721
91neuromuscular process controlling balance (GO:0050885)2.63813048
92appendage development (GO:0048736)2.63427115
93limb development (GO:0060173)2.63427115
94hemoglobin metabolic process (GO:0020027)2.62813559
95glutamate secretion (GO:0014047)2.62552343
96response to lead ion (GO:0010288)2.61890488
97response to pheromone (GO:0019236)2.61826914
98synaptic vesicle exocytosis (GO:0016079)2.60620823
99neuronal stem cell maintenance (GO:0097150)2.59893091
100regulation of centriole replication (GO:0046599)2.59427522
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59262826
102musculoskeletal movement (GO:0050881)2.59184957
103multicellular organismal movement (GO:0050879)2.59184957
104cellular response to cholesterol (GO:0071397)2.58582214
105astrocyte development (GO:0014002)2.57168612
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56154453
107dorsal/ventral axis specification (GO:0009950)2.54567276
108dendritic spine morphogenesis (GO:0060997)2.54184431
109positive regulation of fibroblast migration (GO:0010763)2.53941175
110dermatan sulfate biosynthetic process (GO:0030208)2.52923336
111regulation of synaptic vesicle exocytosis (GO:2000300)2.52132814
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51663131
113neuroblast proliferation (GO:0007405)2.51525527
114synaptic transmission, glutamatergic (GO:0035249)2.51071027
115clathrin coat assembly (GO:0048268)2.50673659
116reciprocal DNA recombination (GO:0035825)2.49860584
117reciprocal meiotic recombination (GO:0007131)2.49860584
118regulation of neuronal synaptic plasticity (GO:0048168)2.49738940
119olfactory bulb development (GO:0021772)2.49713164
120monoubiquitinated protein deubiquitination (GO:0035520)2.46825866
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46148542
122sulfation (GO:0051923)2.45761541
123axonal fasciculation (GO:0007413)2.44998455
124cerebral cortex radially oriented cell migration (GO:0021799)2.44785867
125regulation of DNA endoreduplication (GO:0032875)2.44768488
126somite development (GO:0061053)2.44750193
127stress fiber assembly (GO:0043149)2.44705910
128behavioral response to cocaine (GO:0048148)2.44649552
129replicative senescence (GO:0090399)2.43038495
130nucleobase catabolic process (GO:0046113)2.42857875
131Rap protein signal transduction (GO:0032486)2.42850134
132acidic amino acid transport (GO:0015800)2.42555761
133cellular response to nerve growth factor stimulus (GO:1990090)2.42498537
134response to nerve growth factor (GO:1990089)2.42498537
135central nervous system neuron axonogenesis (GO:0021955)2.41847072
136potassium ion import (GO:0010107)2.41675402
137exploration behavior (GO:0035640)2.40655939
138cytoplasmic mRNA processing body assembly (GO:0033962)2.40308643
139rRNA catabolic process (GO:0016075)2.39811331
140cell proliferation in forebrain (GO:0021846)2.39776396
141microtubule organizing center organization (GO:0031023)2.39624456
142cornea development in camera-type eye (GO:0061303)2.37979570
143L-glutamate transport (GO:0015813)2.37694465
144regulation of glutamate receptor signaling pathway (GO:1900449)2.37314743
145regulation of oligodendrocyte differentiation (GO:0048713)2.37100224
146negative regulation of axonogenesis (GO:0050771)2.37008676
147neuron recognition (GO:0008038)2.36474004
148establishment of nucleus localization (GO:0040023)2.36370980
149central nervous system projection neuron axonogenesis (GO:0021952)2.35338361
150peptidyl-tyrosine autophosphorylation (GO:0038083)2.34972847
151protein K63-linked deubiquitination (GO:0070536)2.34354067
152negative regulation of astrocyte differentiation (GO:0048712)2.33595380
153neuron remodeling (GO:0016322)2.33141842
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.32780907
155neuron-neuron synaptic transmission (GO:0007270)2.32679922
156retina layer formation (GO:0010842)2.32532508
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.32266532
158long-term memory (GO:0007616)2.32174148
159nonmotile primary cilium assembly (GO:0035058)2.32127532
160membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32006629
161long-term synaptic potentiation (GO:0060291)2.31635604
162virion attachment to host cell (GO:0019062)2.30528956
163adhesion of symbiont to host cell (GO:0044650)2.30528956
164regulation of establishment of cell polarity (GO:2000114)2.30337563
165positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29170309
166vesicle transport along microtubule (GO:0047496)2.28372841
167regulation of clathrin-mediated endocytosis (GO:2000369)2.28309671
168microtubule polymerization or depolymerization (GO:0031109)2.28166634
169regulation of excitatory postsynaptic membrane potential (GO:0060079)2.28084578
170porphyrin-containing compound biosynthetic process (GO:0006779)2.26255715
171response to insecticide (GO:0017085)2.23931089
172layer formation in cerebral cortex (GO:0021819)2.22515617
173regulation of collateral sprouting (GO:0048670)2.21966783
174regulation of ARF protein signal transduction (GO:0032012)2.21660515
175presynaptic membrane organization (GO:0097090)2.21314733
176cell differentiation in hindbrain (GO:0021533)2.18466992
177Golgi to endosome transport (GO:0006895)2.17943934
178regulation of synaptic plasticity (GO:0048167)2.17904952
179myelin maintenance (GO:0043217)2.17874064
180actin filament capping (GO:0051693)2.17132753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.85664195
2GBX2_23144817_ChIP-Seq_PC3_Human2.74220373
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62435886
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.57316260
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.52889621
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40165376
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34203285
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34107213
9ZNF274_21170338_ChIP-Seq_K562_Hela2.31000232
10TAF15_26573619_Chip-Seq_HEK293_Human2.27086938
11IGF1R_20145208_ChIP-Seq_DFB_Human2.24949411
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24721433
13FUS_26573619_Chip-Seq_HEK293_Human2.21476085
14* DROSHA_22980978_ChIP-Seq_HELA_Human2.18277012
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16870556
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15976129
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01268188
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01268188
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00296059
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.96432349
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96376992
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95953621
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91066634
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90087034
25TP53_16413492_ChIP-PET_HCT116_Human1.89125205
26EWS_26573619_Chip-Seq_HEK293_Human1.88530886
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87737115
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87294855
29GATA1_19941826_ChIP-Seq_K562_Human1.87046647
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85217727
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.85207826
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82437795
33AR_21572438_ChIP-Seq_LNCaP_Human1.81165823
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79544727
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.78239784
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78006073
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78006073
38* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72480597
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.71198781
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.71048259
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68364450
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.67765523
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67188890
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66534440
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62297567
46VDR_22108803_ChIP-Seq_LS180_Human1.58723075
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57654681
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57010325
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56612460
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53909112
51AR_25329375_ChIP-Seq_VCAP_Human1.51946170
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50564183
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49957186
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49307311
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.49156623
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.47512524
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43050452
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41634227
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40021092
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39600473
61CBP_20019798_ChIP-Seq_JUKART_Human1.39163309
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39163309
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37780123
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35053971
65IRF1_19129219_ChIP-ChIP_H3396_Human1.34392791
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33777665
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33013181
68RUNX2_22187159_ChIP-Seq_PCA_Human1.32967867
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32875432
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.32856573
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31580451
72KDM2B_26808549_Chip-Seq_K562_Human1.30837731
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.29616257
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29358582
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27016519
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26807222
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.26712972
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26606129
79REST_21632747_ChIP-Seq_MESCs_Mouse1.24501633
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24294275
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24294275
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.23723185
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.23062285
84TP53_18474530_ChIP-ChIP_U2OS_Human1.22568472
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21806792
86BCAT_22108803_ChIP-Seq_LS180_Human1.21560743
87AHR_22903824_ChIP-Seq_MCF-7_Human1.21393815
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.21178241
89STAT3_23295773_ChIP-Seq_U87_Human1.19862779
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.19588393
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18301227
92TCF4_22108803_ChIP-Seq_LS180_Human1.18155668
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.17156657
94SMAD4_21799915_ChIP-Seq_A2780_Human1.17132590
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17022279
96* GATA2_19941826_ChIP-Seq_K562_Human1.15479123
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15101610
98JUN_21703547_ChIP-Seq_K562_Human1.15032790
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.14649004
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.14319444
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13815592
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13264424
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.12991053
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.12937167
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12143276
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11970664
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.11530994
108VDR_24787735_ChIP-Seq_THP-1_Human1.09907676
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09680099
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09345196
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.09283739
112RNF2_27304074_Chip-Seq_NSC_Mouse1.09252914
113* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09211969
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.08568223
115KDM2B_26808549_Chip-Seq_REH_Human1.08058367
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07561060
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07260743
118RXR_22108803_ChIP-Seq_LS180_Human1.07258439
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.06974896
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06644283
121TCF4_23295773_ChIP-Seq_U87_Human1.05600436
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04873907
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04800322
124PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04607812
125ER_23166858_ChIP-Seq_MCF-7_Human1.04437453
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.04316070
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04276541
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03193638
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00640119
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00431338
131* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00407076
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00392474
133* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00210581
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99214643
135* AR_19668381_ChIP-Seq_PC3_Human0.98958554
136P53_22387025_ChIP-Seq_ESCs_Mouse0.98689053
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98586060
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97667635
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97631613
140P300_19829295_ChIP-Seq_ESCs_Human0.97223541
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96541510
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.95994085
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.95832962
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95726612
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94208158
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94198686
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93933229
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93197868
149SPI1_23127762_ChIP-Seq_K562_Human0.93182533
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92416734
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.91208152
152KLF5_25053715_ChIP-Seq_YYC3_Human0.91011253
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90131607
154ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89447182
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.88853745
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88776523
157* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88590299
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88233850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98591163
2MP0000920_abnormal_myelination3.46446548
3MP0008877_abnormal_DNA_methylation3.30311027
4MP0003656_abnormal_erythrocyte_physiolo3.14405434
5MP0003690_abnormal_glial_cell3.01947956
6MP0009046_muscle_twitch2.99567223
7MP0004147_increased_porphyrin_level2.97147146
8MP0000569_abnormal_digit_pigmentation2.93740851
9MP0003880_abnormal_central_pattern2.86897707
10MP0003635_abnormal_synaptic_transmissio2.76186001
11MP0008057_abnormal_DNA_replication2.65701518
12MP0005623_abnormal_meninges_morphology2.63583762
13MP0002064_seizures2.62487780
14MP0009745_abnormal_behavioral_response2.27263087
15MP0004270_analgesia2.24587688
16MP0001486_abnormal_startle_reflex2.12381075
17MP0005171_absent_coat_pigmentation2.11699346
18MP0000427_abnormal_hair_cycle2.05872542
19MP0002063_abnormal_learning/memory/cond2.02631428
20MP0002272_abnormal_nervous_system1.99959759
21MP0003634_abnormal_glial_cell1.99229761
22MP0008438_abnormal_cutaneous_collagen1.96894295
23MP0004742_abnormal_vestibular_system1.93832773
24MP0005551_abnormal_eye_electrophysiolog1.93789328
25MP0001984_abnormal_olfaction1.85936617
26MP0003646_muscle_fatigue1.85716548
27MP0005174_abnormal_tail_pigmentation1.84262679
28MP0006292_abnormal_olfactory_placode1.83512315
29MP0004885_abnormal_endolymph1.78404083
30MP0003632_abnormal_nervous_system1.77685990
31MP0008569_lethality_at_weaning1.75381170
32MP0002572_abnormal_emotion/affect_behav1.73750901
33MP0000778_abnormal_nervous_system1.71573381
34MP0001968_abnormal_touch/_nociception1.70075211
35MP0001440_abnormal_grooming_behavior1.68168393
36MP0003329_amyloid_beta_deposits1.67779072
37MP0001299_abnormal_eye_distance/1.64302883
38MP0003890_abnormal_embryonic-extraembry1.64181674
39MP0004858_abnormal_nervous_system1.63825106
40MP0003091_abnormal_cell_migration1.63065913
41MP0002638_abnormal_pupillary_reflex1.60965433
42MP0005423_abnormal_somatic_nervous1.60639085
43MP0003950_abnormal_plasma_membrane1.60624528
44MP0002734_abnormal_mechanical_nocicepti1.58475189
45MP0002736_abnormal_nociception_after1.56400351
46MP0005646_abnormal_pituitary_gland1.54825069
47MP0003172_abnormal_lysosome_physiology1.54009453
48MP0002067_abnormal_sensory_capabilities1.53000462
49MP0005253_abnormal_eye_physiology1.50627801
50MP0005058_abnormal_lysosome_morphology1.48067341
51MP0001958_emphysema1.46283307
52MP0003631_nervous_system_phenotype1.44954589
53MP0003045_fibrosis1.44357086
54MP0008058_abnormal_DNA_repair1.43901248
55MP0005083_abnormal_biliary_tract1.42143149
56MP0000647_abnormal_sebaceous_gland1.41565297
57MP0003121_genomic_imprinting1.39523284
58MP0003937_abnormal_limbs/digits/tail_de1.37824085
59MP0009780_abnormal_chondrocyte_physiolo1.37685126
60MP0003633_abnormal_nervous_system1.37225557
61MP0003718_maternal_effect1.32673258
62MP0000579_abnormal_nail_morphology1.30266342
63MP0004811_abnormal_neuron_physiology1.29819578
64MP0004142_abnormal_muscle_tone1.29772658
65MP0002102_abnormal_ear_morphology1.28581875
66MP0002160_abnormal_reproductive_system1.27547329
67MP0003878_abnormal_ear_physiology1.27065090
68MP0005377_hearing/vestibular/ear_phenot1.27065090
69MP0000631_abnormal_neuroendocrine_gland1.26163470
70MP0003303_peritoneal_inflammation1.25940979
71MP0004134_abnormal_chest_morphology1.22540035
72MP0001970_abnormal_pain_threshold1.21704679
73MP0000604_amyloidosis1.21660917
74MP0002882_abnormal_neuron_morphology1.20674968
75MP0001177_atelectasis1.19796936
76MP0006276_abnormal_autonomic_nervous1.19216712
77MP0005187_abnormal_penis_morphology1.17557629
78MP0002733_abnormal_thermal_nociception1.17448097
79MP0005410_abnormal_fertilization1.16034983
80MP0003300_gastrointestinal_ulcer1.15700722
81MP0002837_dystrophic_cardiac_calcinosis1.15217080
82MP0005409_darkened_coat_color1.15164904
83MP0002735_abnormal_chemical_nociception1.14381155
84MP0002066_abnormal_motor_capabilities/c1.13180544
85MP0002095_abnormal_skin_pigmentation1.12971269
86MP0000955_abnormal_spinal_cord1.12555493
87MP0000733_abnormal_muscle_development1.12039411
88MP0003787_abnormal_imprinting1.10357546
89MP0010678_abnormal_skin_adnexa1.09507386
90MP0003075_altered_response_to1.07920120
91MP0002229_neurodegeneration1.07510631
92MP0003119_abnormal_digestive_system1.07189819
93MP0001501_abnormal_sleep_pattern1.06998871
94MP0008872_abnormal_physiological_respon1.06944884
95MP0003698_abnormal_male_reproductive1.05462736
96MP0006072_abnormal_retinal_apoptosis1.04926614
97MP0001485_abnormal_pinna_reflex1.03387986
98MP0005195_abnormal_posterior_eye1.03370667
99MP0002653_abnormal_ependyma_morphology1.02971106
100MP0005389_reproductive_system_phenotype1.01429525
101MP0002152_abnormal_brain_morphology1.01405468
102MP0004510_myositis1.00366151
103MP0000383_abnormal_hair_follicle0.99846519
104MP0001293_anophthalmia0.99185311
105MP0002752_abnormal_somatic_nervous0.97544755
106MP0004133_heterotaxia0.97184536
107MP0001929_abnormal_gametogenesis0.96950051
108MP0002928_abnormal_bile_duct0.95280353
109MP0002090_abnormal_vision0.94558711
110MP0004043_abnormal_pH_regulation0.91918749
111MP0002557_abnormal_social/conspecific_i0.91154100
112MP0003136_yellow_coat_color0.89499679
113MP0005386_behavior/neurological_phenoty0.88717512
114MP0004924_abnormal_behavior0.88717512
115MP0004130_abnormal_muscle_cell0.87108446
116MP0005391_vision/eye_phenotype0.87029880
117MP0001905_abnormal_dopamine_level0.85855140
118MP0000428_abnormal_craniofacial_morphol0.85513058
119MP0002184_abnormal_innervation0.85475994
120MP0004272_abnormal_basement_membrane0.85098279
121MP0002133_abnormal_respiratory_system0.81870035
122MP0005388_respiratory_system_phenotype0.81870035
123MP0002938_white_spotting0.81101932
124MP0003183_abnormal_peptide_metabolism0.80953384
125MP0005645_abnormal_hypothalamus_physiol0.79756085
126MP0000026_abnormal_inner_ear0.78326288
127MP0001286_abnormal_eye_development0.78045518
128MP0003566_abnormal_cell_adhesion0.77231430
129MP0010094_abnormal_chromosome_stability0.76958114
130MP0002234_abnormal_pharynx_morphology0.76427865
131MP0001502_abnormal_circadian_rhythm0.76300876
132MP0000462_abnormal_digestive_system0.72571521
133MP0005257_abnormal_intraocular_pressure0.71879564
134MP0002295_abnormal_pulmonary_circulatio0.71514948
135MP0005167_abnormal_blood-brain_barrier0.69044247
136MP0002998_abnormal_bone_remodeling0.66943574
137MP0001963_abnormal_hearing_physiology0.66137719
138MP0000747_muscle_weakness0.61585131
139MP0003385_abnormal_body_wall0.61212000
140MP0010307_abnormal_tumor_latency0.61138173
141MP0001943_abnormal_respiration0.60024776
142MP0005310_abnormal_salivary_gland0.58559403
143MP0008874_decreased_physiological_sensi0.58457999
144MP0003453_abnormal_keratinocyte_physiol0.58032022
145MP0001851_eye_inflammation0.56434179
146MP0003861_abnormal_nervous_system0.55125895
147MP0002877_abnormal_melanocyte_morpholog0.52892653
148MP0003279_aneurysm0.52026517
149MP0005164_abnormal_response_to0.51750266
150MP0001529_abnormal_vocalization0.51458412
151MP0005076_abnormal_cell_differentiation0.51085846

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)3.50012820
2Neurofibrillary tangles (HP:0002185)3.47310128
3Poikilocytosis (HP:0004447)3.43622178
4Pancreatic cysts (HP:0001737)3.40703309
5Hyperventilation (HP:0002883)3.35073126
6Pancreatic fibrosis (HP:0100732)3.30701919
7Supranuclear gaze palsy (HP:0000605)3.26974071
8Cerebellar dysplasia (HP:0007033)3.19451534
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.17214165
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.17214165
11Chronic hepatic failure (HP:0100626)3.16629502
12Cerebral inclusion bodies (HP:0100314)3.16266178
13True hermaphroditism (HP:0010459)3.12458711
14Focal motor seizures (HP:0011153)3.08471182
15Focal seizures (HP:0007359)3.07071455
16Molar tooth sign on MRI (HP:0002419)3.06734917
17Abnormality of midbrain morphology (HP:0002418)3.06734917
18Nephronophthisis (HP:0000090)3.03687392
19Insomnia (HP:0100785)2.93517741
20Abnormality of the renal medulla (HP:0100957)2.83690405
21Onion bulb formation (HP:0003383)2.81567803
22Peripheral hypomyelination (HP:0007182)2.81544744
23Partial agenesis of the corpus callosum (HP:0001338)2.80622114
24Premature rupture of membranes (HP:0001788)2.80462590
25Termporal pattern (HP:0011008)2.77486871
26Insidious onset (HP:0003587)2.77486871
27Dysmetria (HP:0001310)2.74956710
28Abnormal auditory evoked potentials (HP:0006958)2.74790007
29Type II lissencephaly (HP:0007260)2.72337043
30Protruding tongue (HP:0010808)2.69310917
31Intention tremor (HP:0002080)2.66671203
32Stomach cancer (HP:0012126)2.65323944
33Progressive cerebellar ataxia (HP:0002073)2.65232723
34Increased cerebral lipofuscin (HP:0011813)2.64970211
35Abnormality of the corticospinal tract (HP:0002492)2.64889568
36Oligodactyly (hands) (HP:0001180)2.64711444
37Atonic seizures (HP:0010819)2.63725250
38Aplasia involving bones of the upper limbs (HP:0009823)2.57992620
39Aplasia of the phalanges of the hand (HP:0009802)2.57992620
40Aplasia involving bones of the extremities (HP:0009825)2.57992620
41Epileptic encephalopathy (HP:0200134)2.52039632
42Drooling (HP:0002307)2.50073994
43Shallow orbits (HP:0000586)2.48587148
44Myokymia (HP:0002411)2.48353707
45Sensory axonal neuropathy (HP:0003390)2.47247998
46Lower limb amyotrophy (HP:0007210)2.46855428
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.45979672
48Dysdiadochokinesis (HP:0002075)2.39163767
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.38845673
50Aqueductal stenosis (HP:0002410)2.38761634
51Birth length less than 3rd percentile (HP:0003561)2.38561396
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.36534548
53Lissencephaly (HP:0001339)2.35597604
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34319010
55Chorioretinal atrophy (HP:0000533)2.33470302
56Spastic gait (HP:0002064)2.33228200
57Postural instability (HP:0002172)2.30433241
58Congenital stationary night blindness (HP:0007642)2.30235937
59Diaphragmatic weakness (HP:0009113)2.29923740
60Relative macrocephaly (HP:0004482)2.29818425
61Papillary thyroid carcinoma (HP:0002895)2.29254706
62Optic nerve hypoplasia (HP:0000609)2.28968149
63Diplopia (HP:0000651)2.27942307
64Abnormality of binocular vision (HP:0011514)2.27942307
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.27693986
66Abnormality of the renal cortex (HP:0011035)2.27102082
67Clumsiness (HP:0002312)2.26804130
68Gaze-evoked nystagmus (HP:0000640)2.26264527
69Arterial tortuosity (HP:0005116)2.26262702
70Glioma (HP:0009733)2.25293602
71Fair hair (HP:0002286)2.25140778
72Volvulus (HP:0002580)2.25124918
73Vascular tortuosity (HP:0004948)2.23858129
74Macroorchidism (HP:0000053)2.23241826
75Scanning speech (HP:0002168)2.20722919
76Excessive salivation (HP:0003781)2.18794149
77Medial flaring of the eyebrow (HP:0010747)2.18675122
78Tubular atrophy (HP:0000092)2.17751520
79Urinary bladder sphincter dysfunction (HP:0002839)2.17447469
80Neuronal loss in central nervous system (HP:0002529)2.16012760
81Reticulocytosis (HP:0001923)2.15740713
82Megalencephaly (HP:0001355)2.14027896
83Truncal ataxia (HP:0002078)2.12521778
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11190352
85Lower limb muscle weakness (HP:0007340)2.07076071
86Cystic liver disease (HP:0006706)2.05433528
87Hemiplegia (HP:0002301)2.05233620
88Colon cancer (HP:0003003)2.05086486
89Absent speech (HP:0001344)2.04167914
90Astrocytoma (HP:0009592)2.03807655
91Abnormality of the astrocytes (HP:0100707)2.03807655
92Slow saccadic eye movements (HP:0000514)2.01619261
93Coronal craniosynostosis (HP:0004440)2.00202820
94Acanthocytosis (HP:0001927)1.98310067
95Premature skin wrinkling (HP:0100678)1.98054857
96Attenuation of retinal blood vessels (HP:0007843)1.97824359
97Chromsome breakage (HP:0040012)1.97174089
98Abnormality of chromosome stability (HP:0003220)1.96080075
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95792681
100Hemiparesis (HP:0001269)1.94761450
101Ankle clonus (HP:0011448)1.94662754
102Visual hallucinations (HP:0002367)1.93379519
103Gait imbalance (HP:0002141)1.93336242
104Abnormality of alanine metabolism (HP:0010916)1.93197402
105Hyperalaninemia (HP:0003348)1.93197402
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93197402
107Depression (HP:0000716)1.93042443
108Abolished electroretinogram (ERG) (HP:0000550)1.92929841
109Cerebral aneurysm (HP:0004944)1.92617215
110Broad-based gait (HP:0002136)1.92298432
111Hypochromic microcytic anemia (HP:0004840)1.91956661
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.91042221
113Poor coordination (HP:0002370)1.90903089
114Generalized tonic-clonic seizures (HP:0002069)1.87891970
115Scapular winging (HP:0003691)1.87795759
116Pendular nystagmus (HP:0012043)1.85429342
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.84855258
118Axonal loss (HP:0003447)1.84355250
119Genital tract atresia (HP:0001827)1.83964892
120Esophageal atresia (HP:0002032)1.83609763
121Anencephaly (HP:0002323)1.83458653
122Mutism (HP:0002300)1.83164066
123Distal lower limb amyotrophy (HP:0008944)1.81859150
124Abnormality of DNA repair (HP:0003254)1.81789746
125Anteriorly placed anus (HP:0001545)1.80334656
126Genetic anticipation (HP:0003743)1.79493259
127Gastrointestinal atresia (HP:0002589)1.78756192
128Preaxial foot polydactyly (HP:0001841)1.77686902
129Abnormal drinking behavior (HP:0030082)1.77357158
130Polydipsia (HP:0001959)1.77357158
131Congenital primary aphakia (HP:0007707)1.77130109
132Dialeptic seizures (HP:0011146)1.77060833
133Decreased motor nerve conduction velocity (HP:0003431)1.75872755
134Inability to walk (HP:0002540)1.75722868
135Truncal obesity (HP:0001956)1.75147041
136Broad metatarsal (HP:0001783)1.74450798
137Abnormality of the nasal septum (HP:0000419)1.74180843
138Sclerocornea (HP:0000647)1.73590989
139Small hand (HP:0200055)1.73194940
140Progressive inability to walk (HP:0002505)1.73154565
141Medulloblastoma (HP:0002885)1.72382365
142Vaginal atresia (HP:0000148)1.72089865
143Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71921609
144Fragile skin (HP:0001030)1.71735216
145Postural tremor (HP:0002174)1.70386406
146Abnormality of the labia minora (HP:0012880)1.69708045
147Thickened helices (HP:0000391)1.69290195
148Patellar aplasia (HP:0006443)1.67886682
149Cholelithiasis (HP:0001081)1.67680490
150Buphthalmos (HP:0000557)1.67507693
151Papilledema (HP:0001085)1.66892487
152Widely spaced teeth (HP:0000687)1.66818941
153Postaxial foot polydactyly (HP:0001830)1.66745691
154Astigmatism (HP:0000483)1.66650887
155Preaxial hand polydactyly (HP:0001177)1.66457446
156Urinary urgency (HP:0000012)1.65940961
157Absence seizures (HP:0002121)1.65190812
158Generalized hypopigmentation of hair (HP:0011358)1.65044208
159Akinesia (HP:0002304)1.64568595
160Highly arched eyebrow (HP:0002553)1.64370488
161Hypoplastic labia majora (HP:0000059)1.64318636
162Short hallux (HP:0010109)1.63888214
163Keratoconus (HP:0000563)1.63631727
164Increased corneal curvature (HP:0100692)1.63631727
165Decreased central vision (HP:0007663)1.63482409
166Absent frontal sinuses (HP:0002688)1.63351547
167Congenital hepatic fibrosis (HP:0002612)1.63350212
168Segmental peripheral demyelination/remyelination (HP:0003481)1.62988590
169Atrophic scars (HP:0001075)1.62586053
170Overriding aorta (HP:0002623)1.62422611
171Increased circulating renin level (HP:0000848)1.61192097
172Febrile seizures (HP:0002373)1.60770293
173Abnormality of liposaccharide metabolism (HP:0010968)1.60244507
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.60244507
175Abnormality of glycolipid metabolism (HP:0010969)1.60244507
176Thick nail (HP:0001805)1.59812422
177Hammertoe (HP:0001765)1.58474457
178Arnold-Chiari malformation (HP:0002308)1.58446104
179Retinal dysplasia (HP:0007973)1.57425896
180Alacrima (HP:0000522)1.56275987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.03907266
2STK393.19345317
3ACVR1B3.17350358
4BMPR1B2.98137215
5PRPF4B2.71121109
6EPHB12.53496174
7OXSR12.43136700
8WNK12.23762813
9ZAK2.19916151
10TNIK2.16276393
11PNCK2.15964944
12EPHA42.13647886
13NTRK32.11761136
14PAK62.08586209
15STK38L1.99662277
16NTRK11.94646103
17MARK11.94273454
18FGR1.91908090
19MAPKAPK51.91840172
20BMX1.77279097
21CAMK1G1.76823773
22PINK11.76026808
23ICK1.73456482
24PKN11.72448044
25RIPK41.65395060
26SGK21.60247157
27FES1.57242358
28TYRO31.49782098
29WNK31.45228083
30CAMK1D1.43081109
31MAP3K91.42985055
32PTK2B1.39323300
33DDR21.39108619
34CDK121.38258320
35ROCK21.37032958
36ADRBK21.32197780
37PRKD31.29314533
38TAOK31.27578475
39PLK21.25559356
40CAMKK11.25174447
41MET1.23243300
42CDK51.20478458
43SGK2231.19847746
44SGK4941.19847746
45TRPM71.13405774
46UHMK11.09965859
47PDGFRB1.09909953
48PTK21.09474865
49DMPK1.08592132
50MAP3K131.08536408
51CAMKK21.08466886
52PLK41.08127400
53MKNK21.07349958
54MAP2K71.06707053
55CDC71.05239583
56MAP3K41.04727080
57MINK11.03625372
58PDK21.02868001
59CDK151.02456478
60DAPK21.00920449
61CDK140.99537784
62MAP4K20.99002481
63SIK20.98793706
64ADRBK10.96184187
65CDK180.95845793
66LIMK10.95743766
67NEK60.94855453
68AKT30.93223573
69MOS0.91445414
70SGK10.90970920
71CAMK2B0.88115941
72CDK190.88100387
73INSRR0.87776792
74CDK11A0.87283653
75CLK10.87239494
76FGFR20.87177586
77NTRK20.85875205
78DYRK1A0.85779435
79BRSK20.85404417
80FYN0.85215264
81GRK10.84973230
82TLK10.84676016
83LATS10.84660597
84CSNK1G20.83502566
85PBK0.83208478
86STK40.82423434
87ERBB20.80368723
88ALK0.78454238
89CASK0.77600996
90PAK30.77467465
91CSNK1G10.77247851
92RET0.75999774
93WNK40.74440374
94RIPK10.74203441
95PDPK10.74073033
96PRKCH0.73765717
97TTN0.73683694
98NUAK10.72604660
99STK110.72373517
100CSNK1A1L0.72133004
101ROCK10.71357949
102CDC42BPA0.71049672
103PAK20.70866703
104PIM10.69711448
105PDGFRA0.68636379
106SCYL20.68414761
107SGK30.67073924
108KSR20.65606086
109MAPK130.64646444
110MELK0.64514540
111CAMK10.63377331
112CAMK2D0.63361238
113MARK20.63005737
114RPS6KA50.62136892
115MAP2K40.61954513
116PLK30.61852061
117CAMK2A0.61205281
118DYRK20.60339553
119BMPR20.60082712
120PRKCQ0.59550981
121TGFBR10.57049223
122PTK60.55861243
123SRC0.55542592
124STK380.54196286
125STK30.53358565
126GRK50.52520913
127CSNK1D0.51774216
128TAOK10.50801141
129PDK10.50664942
130STK100.50208168
131INSR0.49219229
132PRKCE0.48463597
133RPS6KA30.47803158
134MKNK10.47014231
135PRKG10.47006566
136WEE10.46776655
137NEK90.46723001
138PLK10.46133871
139ATM0.45605800
140PRKCG0.45534924
141EGFR0.44806127
142KSR10.44802542
143PRKD10.44514354
144ATR0.44372361
145MAPK100.44069822
146CSNK1G30.44038966
147BCR0.43705201
148PRKCZ0.43483903
149TAF10.43217348
150CDK30.43068249
151CHEK20.42700894
152MAP3K20.41346191
153BRD40.39742442
154PRKAA10.39053907
155GSK3B0.38255533
156PIK3CA0.36804196
157NEK20.36566163
158CSNK1A10.35066658

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.11852822
2Fanconi anemia pathway_Homo sapiens_hsa034601.99611031
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91479448
4Nicotine addiction_Homo sapiens_hsa050331.87658501
5Glutamatergic synapse_Homo sapiens_hsa047241.86813665
6Synaptic vesicle cycle_Homo sapiens_hsa047211.74592641
7Fatty acid biosynthesis_Homo sapiens_hsa000611.69844969
8GABAergic synapse_Homo sapiens_hsa047271.67373644
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60642071
10Salivary secretion_Homo sapiens_hsa049701.59610785
11Morphine addiction_Homo sapiens_hsa050321.57445087
12Circadian entrainment_Homo sapiens_hsa047131.56372928
13Homologous recombination_Homo sapiens_hsa034401.55850012
14Long-term potentiation_Homo sapiens_hsa047201.55417121
15Axon guidance_Homo sapiens_hsa043601.53249533
16Long-term depression_Homo sapiens_hsa047301.50129205
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39892729
18Gastric acid secretion_Homo sapiens_hsa049711.39620490
19Collecting duct acid secretion_Homo sapiens_hsa049661.39221316
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34698407
21Dorso-ventral axis formation_Homo sapiens_hsa043201.34325205
22ABC transporters_Homo sapiens_hsa020101.34297406
23Olfactory transduction_Homo sapiens_hsa047401.33546090
24Glioma_Homo sapiens_hsa052141.33337798
25Basal transcription factors_Homo sapiens_hsa030221.28344407
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27613875
27Cholinergic synapse_Homo sapiens_hsa047251.27407931
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27191085
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26807413
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25880365
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.25107160
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25013561
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22976104
34Non-homologous end-joining_Homo sapiens_hsa034501.22861419
35Alcoholism_Homo sapiens_hsa050341.21878918
36Butanoate metabolism_Homo sapiens_hsa006501.20091538
37Renal cell carcinoma_Homo sapiens_hsa052111.16836339
38Selenocompound metabolism_Homo sapiens_hsa004501.16568292
39Gap junction_Homo sapiens_hsa045401.15900176
40Dopaminergic synapse_Homo sapiens_hsa047281.15221790
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14482739
42Lysine degradation_Homo sapiens_hsa003101.13521866
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12698669
44Systemic lupus erythematosus_Homo sapiens_hsa053221.12608682
45Serotonergic synapse_Homo sapiens_hsa047261.12516909
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12016010
47ErbB signaling pathway_Homo sapiens_hsa040121.10878328
48Oxytocin signaling pathway_Homo sapiens_hsa049211.10807575
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09367253
50Amphetamine addiction_Homo sapiens_hsa050311.08967190
51Renin secretion_Homo sapiens_hsa049241.08748514
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07997868
53GnRH signaling pathway_Homo sapiens_hsa049121.05290625
54Endocytosis_Homo sapiens_hsa041441.05271505
55Hippo signaling pathway_Homo sapiens_hsa043901.02275633
56Malaria_Homo sapiens_hsa051441.02159683
57Ether lipid metabolism_Homo sapiens_hsa005651.01543368
58ECM-receptor interaction_Homo sapiens_hsa045121.01133799
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00751726
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00060638
61Type II diabetes mellitus_Homo sapiens_hsa049300.98392657
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98285011
63Focal adhesion_Homo sapiens_hsa045100.98061142
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97158876
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.96873847
66Estrogen signaling pathway_Homo sapiens_hsa049150.96275132
67Lysosome_Homo sapiens_hsa041420.96189286
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96165752
69Histidine metabolism_Homo sapiens_hsa003400.96026541
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95639716
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95488680
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94685972
73Glycerolipid metabolism_Homo sapiens_hsa005610.94562805
74Cocaine addiction_Homo sapiens_hsa050300.94016531
75Proteoglycans in cancer_Homo sapiens_hsa052050.93551530
76cAMP signaling pathway_Homo sapiens_hsa040240.91892100
77Chronic myeloid leukemia_Homo sapiens_hsa052200.91681392
78Regulation of autophagy_Homo sapiens_hsa041400.91637156
79TGF-beta signaling pathway_Homo sapiens_hsa043500.90813629
80Phagosome_Homo sapiens_hsa041450.90660480
81Hedgehog signaling pathway_Homo sapiens_hsa043400.89598507
82Pancreatic cancer_Homo sapiens_hsa052120.88729571
83Choline metabolism in cancer_Homo sapiens_hsa052310.88554827
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86073061
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86001994
86Platelet activation_Homo sapiens_hsa046110.85224067
87Ras signaling pathway_Homo sapiens_hsa040140.84867640
88Chemokine signaling pathway_Homo sapiens_hsa040620.84299038
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83832952
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83297510
91Rap1 signaling pathway_Homo sapiens_hsa040150.82623594
92MAPK signaling pathway_Homo sapiens_hsa040100.82273402
93Dilated cardiomyopathy_Homo sapiens_hsa054140.81872195
94Nitrogen metabolism_Homo sapiens_hsa009100.81669442
95Calcium signaling pathway_Homo sapiens_hsa040200.81124181
96Non-small cell lung cancer_Homo sapiens_hsa052230.80887685
97Linoleic acid metabolism_Homo sapiens_hsa005910.79515953
98Insulin secretion_Homo sapiens_hsa049110.79338330
99Osteoclast differentiation_Homo sapiens_hsa043800.77007312
100Vibrio cholerae infection_Homo sapiens_hsa051100.76901854
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.76425014
102Ovarian steroidogenesis_Homo sapiens_hsa049130.76424584
103Vitamin B6 metabolism_Homo sapiens_hsa007500.76371016
104Cell cycle_Homo sapiens_hsa041100.75779782
105Steroid biosynthesis_Homo sapiens_hsa001000.75721006
106beta-Alanine metabolism_Homo sapiens_hsa004100.75581387
107Shigellosis_Homo sapiens_hsa051310.75401848
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.74937757
109Taste transduction_Homo sapiens_hsa047420.73817359
110Rheumatoid arthritis_Homo sapiens_hsa053230.73562160
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.73519945
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72762026
113Mineral absorption_Homo sapiens_hsa049780.71758808
114Tight junction_Homo sapiens_hsa045300.71576827
115Circadian rhythm_Homo sapiens_hsa047100.71343673
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71094843
117Amoebiasis_Homo sapiens_hsa051460.70893679
118Salmonella infection_Homo sapiens_hsa051320.70441734
119MicroRNAs in cancer_Homo sapiens_hsa052060.70381985
120Pancreatic secretion_Homo sapiens_hsa049720.69697544
121Melanoma_Homo sapiens_hsa052180.69425300
122Oocyte meiosis_Homo sapiens_hsa041140.69117004
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67894665
124Melanogenesis_Homo sapiens_hsa049160.67880124
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67819515
126Inositol phosphate metabolism_Homo sapiens_hsa005620.67640952
127Nucleotide excision repair_Homo sapiens_hsa034200.66844804
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66617338
129Tryptophan metabolism_Homo sapiens_hsa003800.65773978
130VEGF signaling pathway_Homo sapiens_hsa043700.64309201
131Basal cell carcinoma_Homo sapiens_hsa052170.63847525
132B cell receptor signaling pathway_Homo sapiens_hsa046620.63387327
133Thyroid hormone synthesis_Homo sapiens_hsa049180.63176808
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63008838
135Sphingolipid metabolism_Homo sapiens_hsa006000.62781273
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59533133
137RNA degradation_Homo sapiens_hsa030180.58666051
138FoxO signaling pathway_Homo sapiens_hsa040680.55712011
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.51852488
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50784826
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50377352
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50107985
143p53 signaling pathway_Homo sapiens_hsa041150.44886388
144Purine metabolism_Homo sapiens_hsa002300.44302204
145Bile secretion_Homo sapiens_hsa049760.44017945
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.43961030

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »