SPEF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.58889222
2ventricular system development (GO:0021591)9.37019793
3UTP biosynthetic process (GO:0006228)9.19352751
4nucleoside diphosphate phosphorylation (GO:0006165)8.73170648
5UTP metabolic process (GO:0046051)8.49624205
6left/right axis specification (GO:0070986)8.06752225
7motile cilium assembly (GO:0044458)7.17856334
8CTP biosynthetic process (GO:0006241)6.90995349
9CTP metabolic process (GO:0046036)6.90995349
10guanosine-containing compound biosynthetic process (GO:1901070)6.79632069
11intraciliary transport (GO:0042073)6.36709514
12pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)6.28363310
13pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)5.94253741
14cilium organization (GO:0044782)5.81993068
15otic vesicle formation (GO:0030916)5.43097819
16cilium assembly (GO:0042384)5.33256085
17pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)5.11652983
18cilium morphogenesis (GO:0060271)5.02920749
19nucleotide phosphorylation (GO:0046939)4.83381131
20retinal cone cell development (GO:0046549)4.79825045
21retinal rod cell development (GO:0046548)4.69624452
22* microtubule bundle formation (GO:0001578)4.57800071
23pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.50554607
24microtubule-based movement (GO:0007018)4.47732834
25negative regulation of inclusion body assembly (GO:0090084)4.40962899
26regulation of cilium movement (GO:0003352)4.40905366
27* cellular component assembly involved in morphogenesis (GO:0010927)4.38795337
28fusion of sperm to egg plasma membrane (GO:0007342)4.38131771
29regulation of pigment cell differentiation (GO:0050932)4.31519319
30sperm motility (GO:0030317)4.14732095
31photoreceptor cell maintenance (GO:0045494)4.01941930
32nucleoside diphosphate metabolic process (GO:0009132)3.94871643
33photoreceptor cell differentiation (GO:0046530)3.93251538
34eye photoreceptor cell differentiation (GO:0001754)3.93251538
35protein localization to cilium (GO:0061512)3.91899556
36sensory perception of smell (GO:0007608)3.78459920
37limb bud formation (GO:0060174)3.76613340
38lateral sprouting from an epithelium (GO:0060601)3.75617984
39central nervous system myelination (GO:0022010)3.72116054
40axon ensheathment in central nervous system (GO:0032291)3.72116054
41acrosome assembly (GO:0001675)3.67613673
42single fertilization (GO:0007338)3.67001592
43pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.63292977
44* cell projection assembly (GO:0030031)3.58113159
45multicellular organism reproduction (GO:0032504)3.56853093
46acrosome reaction (GO:0007340)3.54329686
47nonmotile primary cilium assembly (GO:0035058)3.50784910
48spermatid development (GO:0007286)3.48198026
49pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.43901626
50lateral ventricle development (GO:0021670)3.43576292
51sperm-egg recognition (GO:0035036)3.41128614
52one-carbon compound transport (GO:0019755)3.39546046
53positive regulation of developmental pigmentation (GO:0048087)3.38065075
54neural tube formation (GO:0001841)3.37425220
55binding of sperm to zona pellucida (GO:0007339)3.34189919
56regulation of glucose import in response to insulin stimulus (GO:2001273)3.30296710
57regulation of inclusion body assembly (GO:0090083)3.25963927
58heart valve formation (GO:0003188)3.22467119
59plasma membrane fusion (GO:0045026)3.22331771
60vitamin transmembrane transport (GO:0035461)3.20398487
61primary alcohol catabolic process (GO:0034310)3.16687715
62regulation of macrophage chemotaxis (GO:0010758)3.16034728
63pyrimidine ribonucleotide metabolic process (GO:0009218)3.11269469
64smoothened signaling pathway (GO:0007224)3.04834308
65indole-containing compound catabolic process (GO:0042436)3.04707274
66indolalkylamine catabolic process (GO:0046218)3.04707274
67tryptophan catabolic process (GO:0006569)3.04707274
68exogenous drug catabolic process (GO:0042738)3.03375056
69male meiosis (GO:0007140)3.03365955
70cell-cell recognition (GO:0009988)3.02956480
71regulation of mononuclear cell migration (GO:0071675)2.95595245
72response to xenobiotic stimulus (GO:0009410)2.94676338
73microtubule severing (GO:0051013)2.92652601
74meiotic cell cycle (GO:0051321)2.92302290
75microtubule polymerization or depolymerization (GO:0031109)2.92127357
76regulation of interleukin-5 production (GO:0032674)2.87213623
77determination of left/right symmetry (GO:0007368)2.87013270
78diterpenoid biosynthetic process (GO:0016102)2.86571648
79indolalkylamine metabolic process (GO:0006586)2.86351160
80negative regulation of T cell differentiation in thymus (GO:0033085)2.84593771
81ethanol metabolic process (GO:0006067)2.84527118
82photoreceptor cell development (GO:0042461)2.83053826
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.81419565
84drug catabolic process (GO:0042737)2.78427925
85determination of bilateral symmetry (GO:0009855)2.75457975
86microtubule depolymerization (GO:0007019)2.74362615
87specification of symmetry (GO:0009799)2.73885605
88reproduction (GO:0000003)2.71842526
89male meiosis I (GO:0007141)2.71069118
90appendage development (GO:0048736)2.69818877
91limb development (GO:0060173)2.69818877
92purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69307703
93oligodendrocyte differentiation (GO:0048709)2.69141224
94regulation of collateral sprouting (GO:0048670)2.67923522
95eye photoreceptor cell development (GO:0042462)2.67431832
96negative regulation of immunoglobulin mediated immune response (GO:0002890)2.67317428
97negative regulation of B cell mediated immunity (GO:0002713)2.67317428
98benzene-containing compound metabolic process (GO:0042537)2.67273558
99pyrimidine ribonucleoside metabolic process (GO:0046131)2.66655837
100thyroid hormone metabolic process (GO:0042403)2.66169499
101piRNA metabolic process (GO:0034587)2.63703332
102* fertilization (GO:0009566)2.62678918
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62015675
104epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.61243566
105protein polyglutamylation (GO:0018095)2.60788142
106L-fucose metabolic process (GO:0042354)2.59798636
107L-fucose catabolic process (GO:0042355)2.59798636
108fucose catabolic process (GO:0019317)2.59798636
109centriole replication (GO:0007099)2.58312375
110cell wall macromolecule metabolic process (GO:0044036)2.56454214
111cell wall macromolecule catabolic process (GO:0016998)2.56454214
112behavioral response to nicotine (GO:0035095)2.55652425
113positive regulation of meiosis (GO:0045836)2.54866528
114positive regulation of cellular response to insulin stimulus (GO:1900078)2.54435811
115response to pheromone (GO:0019236)2.54424129
116left/right pattern formation (GO:0060972)2.53341099
117negative regulation of humoral immune response (GO:0002921)2.53279492
118tryptophan metabolic process (GO:0006568)2.52804198
119glutathione derivative metabolic process (GO:1901685)2.52643654
120glutathione derivative biosynthetic process (GO:1901687)2.52643654
121oxygen transport (GO:0015671)2.52430731
122organelle assembly (GO:0070925)2.51899993
123regulation of germinal center formation (GO:0002634)2.51498180
124centriole assembly (GO:0098534)2.50846135
125regulation of mesenchymal cell apoptotic process (GO:2001053)2.50347737
126retinoic acid metabolic process (GO:0042573)2.50275913
127regulation of smoothened signaling pathway (GO:0008589)2.50120353
128regulation of microtubule-based movement (GO:0060632)2.49828376
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49233926
130embryonic camera-type eye development (GO:0031076)2.49214205
131pyrimidine nucleotide biosynthetic process (GO:0006221)2.49187404
132spermatid nucleus differentiation (GO:0007289)2.48693596
133kynurenine metabolic process (GO:0070189)2.48588127
134cytoplasmic microtubule organization (GO:0031122)2.48027414
135spinal cord motor neuron differentiation (GO:0021522)2.46181808
136* spermatogenesis (GO:0007283)2.44740557
137* male gamete generation (GO:0048232)2.42753304
138natural killer cell mediated immunity (GO:0002228)2.40167600
139natural killer cell mediated cytotoxicity (GO:0042267)2.40167600
140endocardial cushion morphogenesis (GO:0003203)2.39455810
141inner ear receptor stereocilium organization (GO:0060122)2.39337371
142establishment of protein localization to Golgi (GO:0072600)2.38555995
143positive regulation of meiotic cell cycle (GO:0051446)2.38400671
144rRNA catabolic process (GO:0016075)2.36320445
145sperm capacitation (GO:0048240)2.33360618
146pyrimidine-containing compound transmembrane transport (GO:0072531)2.32719380
147cellular ketone body metabolic process (GO:0046950)2.32549704
148interkinetic nuclear migration (GO:0022027)2.30155153
149cornea development in camera-type eye (GO:0061303)2.29828666
150detection of light stimulus involved in sensory perception (GO:0050962)2.28726566
151detection of light stimulus involved in visual perception (GO:0050908)2.28726566
152* microtubule-based process (GO:0007017)2.27707283
153lung epithelium development (GO:0060428)2.25809814
154tolerance induction (GO:0002507)2.23692694
155indole-containing compound metabolic process (GO:0042430)2.23496854
156thyroid hormone generation (GO:0006590)2.23470440
157neurotransmitter metabolic process (GO:0042133)2.18867166
158nucleus localization (GO:0051647)2.17829516
159glomerular epithelial cell development (GO:0072310)2.17603831
160ethanol oxidation (GO:0006069)2.17060076
161embryonic epithelial tube formation (GO:0001838)2.15052571
162cilium movement (GO:0003341)16.0437656
163axonemal dynein complex assembly (GO:0070286)13.5352494
164cilium or flagellum-dependent cell motility (GO:0001539)13.2683656
165epithelial cilium movement (GO:0003351)12.1969452
166GTP biosynthetic process (GO:0006183)10.3613655
167* axoneme assembly (GO:0035082)10.1663697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.05355275
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01861069
3EZH2_22144423_ChIP-Seq_EOC_Human2.83833272
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77881962
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.65341961
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65315050
7ZNF274_21170338_ChIP-Seq_K562_Hela2.43288671
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42219020
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.12370968
10IGF1R_20145208_ChIP-Seq_DFB_Human2.05657425
11PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91349011
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87843187
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.85933025
14GBX2_23144817_ChIP-Seq_PC3_Human1.81301571
15* SMAD4_21799915_ChIP-Seq_A2780_Human1.78671085
16P300_19829295_ChIP-Seq_ESCs_Human1.77098103
17EWS_26573619_Chip-Seq_HEK293_Human1.76299440
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76085516
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73905287
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71349343
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69603377
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63346041
23TAF15_26573619_Chip-Seq_HEK293_Human1.62611875
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61615480
25CBP_20019798_ChIP-Seq_JUKART_Human1.60450292
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60450292
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60346534
28* DROSHA_22980978_ChIP-Seq_HELA_Human1.57080309
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55733073
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52718701
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52327562
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52263751
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52263751
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50992474
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50933427
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.50753642
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50298768
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49328988
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48554105
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.48308878
41AR_25329375_ChIP-Seq_VCAP_Human1.46440390
42SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.44783000
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44555082
44ER_23166858_ChIP-Seq_MCF-7_Human1.43908926
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.42566641
46AR_21572438_ChIP-Seq_LNCaP_Human1.40720030
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40509831
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40392111
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.40368066
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38678176
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38385721
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.38202148
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37801266
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37281787
55LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36808002
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35662811
57BCAT_22108803_ChIP-Seq_LS180_Human1.35625423
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35357474
59RNF2_27304074_Chip-Seq_NSC_Mouse1.35075203
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.34894459
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.34435426
62RUNX2_22187159_ChIP-Seq_PCA_Human1.33907491
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32614734
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32558834
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.31476303
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.31264274
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30719205
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.29490459
69* STAT3_23295773_ChIP-Seq_U87_Human1.29440239
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28879401
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28110143
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26709310
73TP53_16413492_ChIP-PET_HCT116_Human1.25980532
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25385486
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.24452613
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24004964
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.23790272
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22887267
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22625342
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22560410
81FUS_26573619_Chip-Seq_HEK293_Human1.22423108
82NANOG_19829295_ChIP-Seq_ESCs_Human1.21144907
83SOX2_19829295_ChIP-Seq_ESCs_Human1.21144907
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20871937
85AHR_22903824_ChIP-Seq_MCF-7_Human1.20544880
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19761376
87CDX2_22108803_ChIP-Seq_LS180_Human1.18705458
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.18253273
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18253273
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18024340
91P53_22387025_ChIP-Seq_ESCs_Mouse1.17564732
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17355133
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17316339
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.16768527
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16516816
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16400515
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16333884
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16282892
99* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16219035
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15459656
101* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15304920
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.14895990
103P300_18555785_Chip-Seq_ESCs_Mouse1.14127792
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13933120
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.13135107
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13022935
107ETV1_20927104_ChIP-Seq_GIST48_Human1.12992814
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.12672143
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.12639174
110TP53_18474530_ChIP-ChIP_U2OS_Human1.12050540
111TBL1_22424771_ChIP-Seq_293T_Human1.11323143
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11242534
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.11015871
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10686065
115* TCF4_23295773_ChIP-Seq_U87_Human1.10663242
116JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10621731
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09186027
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08771394
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.08299702
120TP53_22573176_ChIP-Seq_HFKS_Human1.08148720
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.08094041
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08092973
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08043806
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07803888
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06570398
126RNF2_27304074_Chip-Seq_ESCs_Mouse1.06513749
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06362577
128* SMRT_27268052_Chip-Seq_Bcells_Human1.06288501
129TCF4_22108803_ChIP-Seq_LS180_Human1.06254226
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.06066134
131REST_21632747_ChIP-Seq_MESCs_Mouse1.05825130
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.05465760
133PHF8_20622853_ChIP-Seq_HELA_Human1.04685997
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04635046
135NFYB_21822215_ChIP-Seq_K562_Human1.02040635
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00659203
137NFYA_21822215_ChIP-Seq_K562_Human1.00426135
138TP63_23658742_ChIP-Seq_EP156T_Human0.99441751
139RXR_22108803_ChIP-Seq_LS180_Human0.99380981
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99234886
141NCOR_22424771_ChIP-Seq_293T_Human0.98801815
142AR_20517297_ChIP-Seq_VCAP_Human0.97928314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.09305661
2MP0005410_abnormal_fertilization4.52199846
3MP0001984_abnormal_olfaction4.32429353
4MP0008875_abnormal_xenobiotic_pharmacok3.84802994
5MP0002653_abnormal_ependyma_morphology3.80457345
6MP0005623_abnormal_meninges_morphology3.59564347
7MP0004043_abnormal_pH_regulation3.21301637
8MP0004381_abnormal_hair_follicle2.93460985
9MP0008004_abnormal_stomach_pH2.66963910
10MP0002282_abnormal_trachea_morphology2.44393190
11MP0002938_white_spotting2.30991766
12MP0005646_abnormal_pituitary_gland2.27768041
13MP0003195_calcinosis2.22805341
14MP0002638_abnormal_pupillary_reflex2.19178590
15MP0003698_abnormal_male_reproductive2.08845451
16MP0004133_heterotaxia1.99197356
17MP0005075_abnormal_melanosome_morpholog1.90136771
18MP0002876_abnormal_thyroid_physiology1.85905986
19MP0002102_abnormal_ear_morphology1.83506866
20MP0001851_eye_inflammation1.81759921
21MP0001929_abnormal_gametogenesis1.81623039
22MP0004885_abnormal_endolymph1.77780454
23MP0003937_abnormal_limbs/digits/tail_de1.72335901
24MP0000569_abnormal_digit_pigmentation1.71636517
25MP0004742_abnormal_vestibular_system1.70044401
26MP0010678_abnormal_skin_adnexa1.68761989
27MP0003938_abnormal_ear_development1.66073150
28MP0000427_abnormal_hair_cycle1.64377235
29MP0000428_abnormal_craniofacial_morphol1.63049777
30MP0001485_abnormal_pinna_reflex1.62930631
31MP0003724_increased_susceptibility_to1.62450545
32MP0002928_abnormal_bile_duct1.59919415
33MP0003878_abnormal_ear_physiology1.59176687
34MP0005377_hearing/vestibular/ear_phenot1.59176687
35MP0002160_abnormal_reproductive_system1.58522256
36MP0002249_abnormal_larynx_morphology1.56602512
37MP0008877_abnormal_DNA_methylation1.54882301
38MP0000566_synostosis1.54133826
39MP0000778_abnormal_nervous_system1.54120097
40MP0001968_abnormal_touch/_nociception1.51823242
41MP0009250_abnormal_appendicular_skeleto1.50847926
42MP0009046_muscle_twitch1.50375997
43MP0004858_abnormal_nervous_system1.49965889
44MP0001501_abnormal_sleep_pattern1.47834238
45MP0006276_abnormal_autonomic_nervous1.45449142
46MP0003690_abnormal_glial_cell1.44918403
47MP0009780_abnormal_chondrocyte_physiolo1.42572094
48MP0002734_abnormal_mechanical_nocicepti1.41273844
49MP0010386_abnormal_urinary_bladder1.40675171
50MP0002735_abnormal_chemical_nociception1.34004056
51MP0001440_abnormal_grooming_behavior1.33946854
52MP0003880_abnormal_central_pattern1.33064496
53MP0004147_increased_porphyrin_level1.32511016
54MP0002405_respiratory_system_inflammati1.32386284
55MP0002557_abnormal_social/conspecific_i1.28576421
56MP0005645_abnormal_hypothalamus_physiol1.27900332
57MP0001970_abnormal_pain_threshold1.26879396
58MP0008872_abnormal_physiological_respon1.26787156
59MP0003634_abnormal_glial_cell1.24576357
60MP0002132_abnormal_respiratory_system1.21797491
61MP0001299_abnormal_eye_distance/1.21211185
62MP0002210_abnormal_sex_determination1.21037005
63MP0001293_anophthalmia1.20731900
64MP0000049_abnormal_middle_ear1.20541207
65MP0005388_respiratory_system_phenotype1.20181898
66MP0002133_abnormal_respiratory_system1.20181898
67MP0005551_abnormal_eye_electrophysiolog1.19969167
68MP0001765_abnormal_ion_homeostasis1.19865172
69MP0002254_reproductive_system_inflammat1.17145169
70MP0001486_abnormal_startle_reflex1.15427004
71MP0002116_abnormal_craniofacial_bone1.11821657
72MP0005195_abnormal_posterior_eye1.11316643
73MP0001958_emphysema1.10981375
74MP0002277_abnormal_respiratory_mucosa1.08718860
75MP0000383_abnormal_hair_follicle1.06469936
76MP0005174_abnormal_tail_pigmentation1.06219321
77MP0003950_abnormal_plasma_membrane1.05604348
78MP0002909_abnormal_adrenal_gland1.05460078
79MP0001324_abnormal_eye_pigmentation1.04691051
80MP0003303_peritoneal_inflammation1.04345245
81MP0008995_early_reproductive_senescence1.03741842
82MP0002161_abnormal_fertility/fecundity1.03333915
83MP0002229_neurodegeneration1.03145301
84MP0004019_abnormal_vitamin_homeostasis0.99717976
85MP0005085_abnormal_gallbladder_physiolo0.99328566
86MP0002736_abnormal_nociception_after0.98945826
87MP0002822_catalepsy0.98730317
88MP0005083_abnormal_biliary_tract0.98629464
89MP0000026_abnormal_inner_ear0.96767964
90MP0002067_abnormal_sensory_capabilities0.95740091
91MP0001270_distended_abdomen0.95626692
92MP0004142_abnormal_muscle_tone0.95186255
93MP0000372_irregular_coat_pigmentation0.95118008
94MP0003279_aneurysm0.94945968
95MP0001145_abnormal_male_reproductive0.94865341
96MP0002837_dystrophic_cardiac_calcinosis0.92701779
97MP0001340_abnormal_eyelid_morphology0.92697273
98MP0003942_abnormal_urinary_system0.92430014
99MP0002092_abnormal_eye_morphology0.90774453
100MP0004134_abnormal_chest_morphology0.90676117
101MP0005391_vision/eye_phenotype0.89500046
102MP0000631_abnormal_neuroendocrine_gland0.89445721
103MP0000653_abnormal_sex_gland0.88189376
104MP0001177_atelectasis0.87611950
105MP0005389_reproductive_system_phenotype0.87047043
106MP0002233_abnormal_nose_morphology0.86590422
107MP0000470_abnormal_stomach_morphology0.86259513
108MP0003763_abnormal_thymus_physiology0.86033634
109MP0003635_abnormal_synaptic_transmissio0.83952664
110MP0002733_abnormal_thermal_nociception0.83243844
111MP0002168_other_aberrant_phenotype0.82024040
112MP0006072_abnormal_retinal_apoptosis0.81752499
113MP0003646_muscle_fatigue0.81600677
114MP0003633_abnormal_nervous_system0.80905457
115MP0000920_abnormal_myelination0.80845964
116MP0002572_abnormal_emotion/affect_behav0.79491400
117MP0005220_abnormal_exocrine_pancreas0.79122574
118MP0000432_abnormal_head_morphology0.78805356
119MP0002064_seizures0.78777900
120MP0001986_abnormal_taste_sensitivity0.78617095
121MP0002272_abnormal_nervous_system0.78080715
122MP0003861_abnormal_nervous_system0.77617350
123MP0006292_abnormal_olfactory_placode0.77594266
124MP0001502_abnormal_circadian_rhythm0.77085756
125MP0005636_abnormal_mineral_homeostasis0.77048298
126MP0002109_abnormal_limb_morphology0.76993087
127MP0002063_abnormal_learning/memory/cond0.76941288
128MP0002752_abnormal_somatic_nervous0.76924014
129MP0005395_other_phenotype0.76029986
130MP0005310_abnormal_salivary_gland0.75589252
131MP0003787_abnormal_imprinting0.74730127
132MP0000762_abnormal_tongue_morphology0.74376721
133MP0002152_abnormal_brain_morphology0.72473919
134MP0005394_taste/olfaction_phenotype0.72218881
135MP0005499_abnormal_olfactory_system0.72218881
136MP0009745_abnormal_behavioral_response0.71995610
137MP0003943_abnormal_hepatobiliary_system0.71108012
138MP0001664_abnormal_digestion0.70674861
139MP0001963_abnormal_hearing_physiology0.70416847
140MP0008789_abnormal_olfactory_epithelium0.69538127
141MP0001346_abnormal_lacrimal_gland0.69022612
142MP0005187_abnormal_penis_morphology0.68433732
143MP0005253_abnormal_eye_physiology0.68292954
144MP0000955_abnormal_spinal_cord0.67881388
145MP0004145_abnormal_muscle_electrophysio0.67663571
146MP0003075_altered_response_to0.66936720
147MP0002882_abnormal_neuron_morphology0.66819701
148MP0001663_abnormal_digestive_system0.66154081
149MP0006054_spinal_hemorrhage0.66139180
150MP0003045_fibrosis0.65397995
151MP0001873_stomach_inflammation0.65195725

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.64068676
2Abnormal respiratory motile cilium morphology (HP:0005938)8.94213539
3Abnormal respiratory epithelium morphology (HP:0012253)8.94213539
4Absent/shortened dynein arms (HP:0200106)8.38587944
5Dynein arm defect of respiratory motile cilia (HP:0012255)8.38587944
6Chronic bronchitis (HP:0004469)6.71190933
7Bronchiectasis (HP:0002110)5.61851327
8Nasal polyposis (HP:0100582)4.60250753
9True hermaphroditism (HP:0010459)4.54985950
10Pancreatic fibrosis (HP:0100732)4.45032387
11Recurrent sinusitis (HP:0011108)4.08774459
12Chronic sinusitis (HP:0011109)3.74032758
13Abnormality of the nasal mucosa (HP:0000433)3.73914008
14Bronchitis (HP:0012387)3.73703913
15Nephronophthisis (HP:0000090)3.51939513
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.32320839
17Pancreatic cysts (HP:0001737)3.10707033
18Occipital encephalocele (HP:0002085)3.07663413
19Median cleft lip (HP:0000161)3.07447622
20Molar tooth sign on MRI (HP:0002419)3.02642089
21Abnormality of midbrain morphology (HP:0002418)3.02642089
22Postaxial foot polydactyly (HP:0001830)2.88446576
23Cystic liver disease (HP:0006706)2.88356207
24Abnormal rod and cone electroretinograms (HP:0008323)2.79946667
25Supernumerary spleens (HP:0009799)2.79657467
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.78160299
27Congenital hepatic fibrosis (HP:0002612)2.77045891
28Abnormality of the renal medulla (HP:0100957)2.76156423
29Infertility (HP:0000789)2.75525534
30Recurrent otitis media (HP:0000403)2.75440952
31Tubulointerstitial nephritis (HP:0001970)2.69167295
32Abnormal biliary tract physiology (HP:0012439)2.63494012
33Bile duct proliferation (HP:0001408)2.63494012
34Medial flaring of the eyebrow (HP:0010747)2.60696926
35Chronic hepatic failure (HP:0100626)2.49390269
36Fibular hypoplasia (HP:0003038)2.47157384
37Gait imbalance (HP:0002141)2.35741654
38Congenital primary aphakia (HP:0007707)2.33419973
39Chronic otitis media (HP:0000389)2.29969744
40Decreased circulating renin level (HP:0003351)2.29922503
41Tubular atrophy (HP:0000092)2.27112064
42Abnormality of permanent molar morphology (HP:0011071)2.26118836
43Abnormality of the dental root (HP:0006486)2.26118836
44Taurodontia (HP:0000679)2.26118836
45Abnormality of dentin (HP:0010299)2.24138320
46Preaxial hand polydactyly (HP:0001177)2.20807736
47Hyperactive renin-angiotensin system (HP:0000841)2.19475309
48Abnormality of molar (HP:0011077)2.15537541
49Abnormality of molar morphology (HP:0011070)2.15537541
50Anencephaly (HP:0002323)2.10629308
51Genital tract atresia (HP:0001827)2.09526891
52Abnormality of the dental pulp (HP:0006479)2.06234566
53Male pseudohermaphroditism (HP:0000037)2.01948910
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9283872
55Abnormal respiratory motile cilium physiology (HP:0012261)12.0848419
56Abnormal ciliary motility (HP:0012262)11.7054629
57Nephrogenic diabetes insipidus (HP:0009806)1.99617357
58Postaxial hand polydactyly (HP:0001162)1.99085747
59Sclerocornea (HP:0000647)1.98884253
60Facial cleft (HP:0002006)1.93156451
61Tubulointerstitial abnormality (HP:0001969)1.92360093
62Bony spicule pigmentary retinopathy (HP:0007737)1.91976251
63Vaginal atresia (HP:0000148)1.91303750
64Congenital stationary night blindness (HP:0007642)1.85207995
65Esophageal neoplasm (HP:0100751)1.81722138
66Neoplasm of head and neck (HP:0012288)1.81722138
67Stage 5 chronic kidney disease (HP:0003774)1.77443330
68Abnormal sex determination (HP:0012244)1.77309765
69Sex reversal (HP:0012245)1.77309765
70Recurrent bronchitis (HP:0002837)1.75379233
71Bifid tongue (HP:0010297)1.72036190
72Midline defect of the nose (HP:0004122)1.70704927
73Neonatal short-limb short stature (HP:0008921)1.70695397
74Abnormality of the renal cortex (HP:0011035)1.67404904
75Oculomotor apraxia (HP:0000657)1.67029787
76Poor coordination (HP:0002370)1.65060354
77Bronchomalacia (HP:0002780)1.64785115
78Atelectasis (HP:0100750)1.64757189
79Retinitis pigmentosa (HP:0000510)1.64662256
80Gaze-evoked nystagmus (HP:0000640)1.61814390
81Abnormal drinking behavior (HP:0030082)1.61639744
82Polydipsia (HP:0001959)1.61639744
83Bell-shaped thorax (HP:0001591)1.61238849
84Cone-rod dystrophy (HP:0000548)1.59490858
85Polyuria (HP:0000103)1.59388991
86Attenuation of retinal blood vessels (HP:0007843)1.58597770
87Hypotelorism (HP:0000601)1.58181298
88Abolished electroretinogram (ERG) (HP:0000550)1.57641426
89Abnormality of macular pigmentation (HP:0008002)1.56849343
90Concave nail (HP:0001598)1.56267171
91Hyperaldosteronism (HP:0000859)1.55140126
92Abnormality of renin-angiotensin system (HP:0000847)1.53376427
93Ectopic anus (HP:0004397)1.53266803
94Hyperventilation (HP:0002883)1.52296354
95Hypokalemic alkalosis (HP:0001949)1.51503058
96Nephropathy (HP:0000112)1.51261173
97Progressive cerebellar ataxia (HP:0002073)1.50828977
98Asplenia (HP:0001746)1.50510381
99Renal salt wasting (HP:0000127)1.50392440
100Hyperkalemia (HP:0002153)1.50220226
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.47816989
102Central scotoma (HP:0000603)1.46872743
103Furrowed tongue (HP:0000221)1.46583193
104Absent speech (HP:0001344)1.45795556
105Aplasia involving bones of the upper limbs (HP:0009823)1.45636937
106Aplasia of the phalanges of the hand (HP:0009802)1.45636937
107Aplasia involving bones of the extremities (HP:0009825)1.45636937
108Microglossia (HP:0000171)1.44789858
109Type II lissencephaly (HP:0007260)1.44622303
110Omphalocele (HP:0001539)1.44471727
111Abnormality of abdominal situs (HP:0011620)1.42208079
112Abdominal situs inversus (HP:0003363)1.42208079
113Broad distal phalanx of finger (HP:0009836)1.42127841
114Prominent nasal bridge (HP:0000426)1.39656771
115Aplasia/Hypoplasia of the lens (HP:0008063)1.39103693
116Narrow forehead (HP:0000341)1.37680788
117Multicystic kidney dysplasia (HP:0000003)1.36283126
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.35834937
119Tubulointerstitial fibrosis (HP:0005576)1.34541792
120Hypodontia (HP:0000668)1.32060915
121Abnormality of renal excretion (HP:0011036)1.30972638
122Aganglionic megacolon (HP:0002251)1.30269121
12311 pairs of ribs (HP:0000878)1.29759996
124Genetic anticipation (HP:0003743)1.28579673
125Broad foot (HP:0001769)1.28372926
126Specific learning disability (HP:0001328)1.26304975
127Coronal craniosynostosis (HP:0004440)1.24695598
128Abnormality of chloride homeostasis (HP:0011422)1.24512966
129Abnormal urine output (HP:0012590)1.23935166
130Decreased central vision (HP:0007663)1.23817674
131Abnormality of the parietal bone (HP:0002696)1.23121633
132Male infertility (HP:0003251)1.20066134
133Short ribs (HP:0000773)1.19237346
134Constricted visual fields (HP:0001133)1.17932136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.47732777
2PNCK6.85098970
3FRK6.05589347
4MST42.92751312
5NLK2.85258119
6MAP4K22.47672337
7MAP2K22.41943107
8STK392.17583604
9ACVR1B1.91563711
10PDK31.87807656
11PDK41.87807656
12TNIK1.84972642
13IRAK11.76902640
14TAOK31.74132282
15PINK11.71535472
16WNK31.68368266
17VRK11.64464690
18INSRR1.61284601
19STK38L1.54905442
20CSNK1G11.54559183
21MAP3K41.49955079
22SIK11.49834018
23DYRK31.40176171
24MAPKAPK31.38111511
25GRK11.36044980
26LATS11.31716002
27TEC1.25199658
28FGFR21.19182222
29CDK31.18055514
30ADRBK11.16562130
31NTRK21.16178932
32WEE11.13492896
33TLK11.12986323
34STK101.12130354
35PAK31.11096496
36ITK1.06277658
37ZAK1.04848290
38DAPK21.02227215
39MAPKAPK51.02062554
40GSK3A0.99864353
41EPHB10.98975625
42MAP2K70.96544369
43RPS6KA20.96222156
44WNK10.93788795
45NTRK30.93387070
46WNK40.92829343
47MAP3K70.92189773
48PTK2B0.92181899
49NME10.91085820
50PDK20.90272932
51CAMKK20.89845533
52MKNK20.89777768
53EPHA40.89390259
54PKN10.89155383
55ADRBK20.88003621
56SGK20.84921484
57RPS6KA40.83247040
58ERBB20.82586684
59TNK20.82113562
60PAK20.81523500
61SGK2230.80582838
62SGK4940.80582838
63CSNK1A1L0.78538275
64STK160.78412423
65ROCK20.78246299
66MUSK0.76944637
67RPS6KA50.74854217
68DYRK1A0.72471153
69HIPK20.71830896
70LMTK20.71487479
71ICK0.68698363
72STK30.67302808
73IRAK20.66907660
74EPHA20.66617404
75CASK0.66308570
76STK380.66218317
77OXSR10.65766418
78PHKG10.65604721
79PHKG20.65604721
80PRKCQ0.63506275
81PLK20.61271823
82ROCK10.60421805
83PRKAA20.60340137
84NUAK10.59843623
85EPHA30.58572817
86TGFBR10.57778276
87GRK70.57686182
88MARK20.57225311
89BCKDK0.55463119
90CAMK2A0.55351778
91CSNK1G30.54761333
92DMPK0.54655537
93AURKA0.53217268
94PIK3CA0.52665141
95STK110.51846887
96FER0.51645755
97MAPKAPK20.51440481
98SGK30.50528621
99RPS6KL10.48501085
100RPS6KC10.48501085
101PRKCG0.47712622
102STK240.47102847
103BTK0.47064485
104CAMK1G0.45588334
105TXK0.44826916
106FES0.44152740
107CDK190.43658072
108CSK0.43628127
109BMPR1B0.43076451
110RPS6KA60.42746640
111MAP3K120.42355749
112CAMK2B0.41741384
113NEK60.41517253
114MAPK70.39728535
115TRPM70.38722148
116MAP2K40.38721365
117PRKG10.37863990
118CAMK10.37327780
119SIK20.37187978
120BCR0.37036322
121CAMKK10.36074401
122MAPK40.35709863
123ABL10.35622144
124PRKCA0.34962355
125BRSK20.34596018
126TIE10.34507368
127CSNK1G20.33810748
128PRKCI0.32777533
129MKNK10.32180007
130MAP3K20.31930628
131BLK0.31879013
132SGK10.31793767
133CHUK0.30637123
134IKBKB0.29970614
135OBSCN0.29794395
136MAPK90.29350627
137CSNK1A10.28507678
138KIT0.28476253
139FYN0.28465766
140ERBB30.28144410
141CAMK2D0.27874510
142PRKCE0.27158135
143MAPK130.26626521
144MAPK30.25981226
145PRKACA0.25943701
146TGFBR20.25540840
147MARK10.24810755

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.77879094
2Huntingtons disease_Homo sapiens_hsa050162.49513238
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38698939
4Vitamin B6 metabolism_Homo sapiens_hsa007502.34672706
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.27163560
6Nitrogen metabolism_Homo sapiens_hsa009102.26940063
7Histidine metabolism_Homo sapiens_hsa003402.24967147
8Caffeine metabolism_Homo sapiens_hsa002321.97394855
9beta-Alanine metabolism_Homo sapiens_hsa004101.90914241
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90857950
11Hedgehog signaling pathway_Homo sapiens_hsa043401.88612872
12Amphetamine addiction_Homo sapiens_hsa050311.86404020
13Dorso-ventral axis formation_Homo sapiens_hsa043201.86050317
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84534071
15Tryptophan metabolism_Homo sapiens_hsa003801.79811548
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.68363913
17Basal cell carcinoma_Homo sapiens_hsa052171.67366595
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.63041626
19Gastric acid secretion_Homo sapiens_hsa049711.62832394
20Phototransduction_Homo sapiens_hsa047441.61013040
21Circadian rhythm_Homo sapiens_hsa047101.57599340
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56859769
23Ether lipid metabolism_Homo sapiens_hsa005651.52895407
24Tyrosine metabolism_Homo sapiens_hsa003501.48043334
25Circadian entrainment_Homo sapiens_hsa047131.36596714
26Taste transduction_Homo sapiens_hsa047421.34008282
27Cocaine addiction_Homo sapiens_hsa050301.33125328
28Estrogen signaling pathway_Homo sapiens_hsa049151.29516847
29Phenylalanine metabolism_Homo sapiens_hsa003601.28770339
30cAMP signaling pathway_Homo sapiens_hsa040241.28488642
31Propanoate metabolism_Homo sapiens_hsa006401.28254661
32Peroxisome_Homo sapiens_hsa041461.26562414
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.26135921
34Glutamatergic synapse_Homo sapiens_hsa047241.25346949
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23114134
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22161343
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21059794
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18157397
39Wnt signaling pathway_Homo sapiens_hsa043101.16111566
40Thyroid hormone synthesis_Homo sapiens_hsa049181.14236874
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13575341
42Renin secretion_Homo sapiens_hsa049241.12090284
43Insulin secretion_Homo sapiens_hsa049111.11490044
44PPAR signaling pathway_Homo sapiens_hsa033201.10827687
45Axon guidance_Homo sapiens_hsa043601.08100989
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08048756
47T cell receptor signaling pathway_Homo sapiens_hsa046601.05955982
48Calcium signaling pathway_Homo sapiens_hsa040201.02319963
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02052968
50B cell receptor signaling pathway_Homo sapiens_hsa046621.00300399
51Allograft rejection_Homo sapiens_hsa053300.98755171
52Morphine addiction_Homo sapiens_hsa050320.97151515
53Ovarian steroidogenesis_Homo sapiens_hsa049130.95370276
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92544550
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92537982
56ABC transporters_Homo sapiens_hsa020100.91055846
57GABAergic synapse_Homo sapiens_hsa047270.90233095
58Mineral absorption_Homo sapiens_hsa049780.89782979
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88814246
60Glucagon signaling pathway_Homo sapiens_hsa049220.85994444
61Arachidonic acid metabolism_Homo sapiens_hsa005900.85218609
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84892082
63Pyruvate metabolism_Homo sapiens_hsa006200.84283002
64Salivary secretion_Homo sapiens_hsa049700.84114671
65Fatty acid degradation_Homo sapiens_hsa000710.83124706
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.82636860
67Retinol metabolism_Homo sapiens_hsa008300.81254738
68Fatty acid biosynthesis_Homo sapiens_hsa000610.80973158
69Linoleic acid metabolism_Homo sapiens_hsa005910.79423837
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79116413
71Rheumatoid arthritis_Homo sapiens_hsa053230.76715114
72Prostate cancer_Homo sapiens_hsa052150.76237403
73Nicotine addiction_Homo sapiens_hsa050330.75678217
74Autoimmune thyroid disease_Homo sapiens_hsa053200.75522747
75Osteoclast differentiation_Homo sapiens_hsa043800.74892820
76Fatty acid elongation_Homo sapiens_hsa000620.74674006
77Glutathione metabolism_Homo sapiens_hsa004800.74533510
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71188860
79Sphingolipid metabolism_Homo sapiens_hsa006000.71109177
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.70564286
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69897326
82Glycerolipid metabolism_Homo sapiens_hsa005610.68707170
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.67288658
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67088335
85MAPK signaling pathway_Homo sapiens_hsa040100.65967344
86Regulation of autophagy_Homo sapiens_hsa041400.65910616
87Fanconi anemia pathway_Homo sapiens_hsa034600.65788873
88Antigen processing and presentation_Homo sapiens_hsa046120.65393788
89Chemical carcinogenesis_Homo sapiens_hsa052040.64808292
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64229520
91Dopaminergic synapse_Homo sapiens_hsa047280.64012154
92Malaria_Homo sapiens_hsa051440.63694237
93Serotonergic synapse_Homo sapiens_hsa047260.63679435
94Pathways in cancer_Homo sapiens_hsa052000.63015736
95Selenocompound metabolism_Homo sapiens_hsa004500.62574699
96Cholinergic synapse_Homo sapiens_hsa047250.62232612
97Protein export_Homo sapiens_hsa030600.59764828
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58760877
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57971429
100Melanogenesis_Homo sapiens_hsa049160.57784324
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57731976
102Ras signaling pathway_Homo sapiens_hsa040140.54143234
103Graft-versus-host disease_Homo sapiens_hsa053320.53206319
104Sulfur metabolism_Homo sapiens_hsa009200.52332152
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52300507
106Pancreatic secretion_Homo sapiens_hsa049720.52137030
107Hippo signaling pathway_Homo sapiens_hsa043900.51764060
108Collecting duct acid secretion_Homo sapiens_hsa049660.50032154
109Oxidative phosphorylation_Homo sapiens_hsa001900.49841678
110Alcoholism_Homo sapiens_hsa050340.49519245
111Butanoate metabolism_Homo sapiens_hsa006500.48957165
112Salmonella infection_Homo sapiens_hsa051320.48585202
113Asthma_Homo sapiens_hsa053100.46699039
114Tight junction_Homo sapiens_hsa045300.45030930
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.44596688
116Primary immunodeficiency_Homo sapiens_hsa053400.44530497
117Basal transcription factors_Homo sapiens_hsa030220.44377211
118Arginine and proline metabolism_Homo sapiens_hsa003300.44046541
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43724853
120Oxytocin signaling pathway_Homo sapiens_hsa049210.43408093
121TGF-beta signaling pathway_Homo sapiens_hsa043500.42212580
122Metabolic pathways_Homo sapiens_hsa011000.41063819
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40568751
124Homologous recombination_Homo sapiens_hsa034400.40281809
125Hematopoietic cell lineage_Homo sapiens_hsa046400.39840708
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39803547
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39712435
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39605272
129Choline metabolism in cancer_Homo sapiens_hsa052310.38921328
130ECM-receptor interaction_Homo sapiens_hsa045120.38240631
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.37948664
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37837966
133Notch signaling pathway_Homo sapiens_hsa043300.37673924
134Cardiac muscle contraction_Homo sapiens_hsa042600.37296428
135Type I diabetes mellitus_Homo sapiens_hsa049400.33894837
136Starch and sucrose metabolism_Homo sapiens_hsa005000.32565288
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32377809
138Long-term depression_Homo sapiens_hsa047300.27528035
139Purine metabolism_Homo sapiens_hsa002300.26976297

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