SPEG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.19954436
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.83487515
3cardiac myofibril assembly (GO:0055003)5.83107129
4plasma membrane repair (GO:0001778)5.72256183
5myofibril assembly (GO:0030239)5.53888442
6actin-myosin filament sliding (GO:0033275)5.52506638
7muscle filament sliding (GO:0030049)5.52506638
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.38101336
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.32371335
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.28141945
11regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.08880384
12cardiac muscle contraction (GO:0060048)5.03068903
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.02274255
14regulation of skeletal muscle contraction (GO:0014819)5.01108894
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.95602235
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.91234507
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.90857983
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.89898919
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.60857814
20actin-mediated cell contraction (GO:0070252)4.52170907
21cell communication by electrical coupling (GO:0010644)4.49896899
22regulation of membrane repolarization (GO:0060306)4.39466690
23regulation of actin filament-based movement (GO:1903115)4.38165857
24striated muscle contraction (GO:0006941)4.36954735
25regulation of cell communication by electrical coupling (GO:0010649)4.36040894
26creatine metabolic process (GO:0006600)4.31825329
27response to muscle activity (GO:0014850)4.28124676
28skeletal muscle fiber development (GO:0048741)4.27986550
29actomyosin structure organization (GO:0031032)4.24130659
30regulation of synapse structural plasticity (GO:0051823)4.21329366
31cell communication involved in cardiac conduction (GO:0086065)4.17773170
32adult heart development (GO:0007512)4.10634062
33regulation of relaxation of muscle (GO:1901077)4.07709230
34ventricular cardiac muscle cell action potential (GO:0086005)4.03883429
35myotube cell development (GO:0014904)3.94581071
36cardiac muscle hypertrophy (GO:0003300)3.91078913
37positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.89604687
38regulation of striated muscle contraction (GO:0006942)3.85301850
39regulation of calcium ion transmembrane transporter activity (GO:1901019)3.78678899
40regulation of calcium ion transmembrane transport (GO:1903169)3.78678899
41striated muscle hypertrophy (GO:0014897)3.77364030
42muscle fiber development (GO:0048747)3.76300036
43* cardiac muscle cell development (GO:0055013)3.75631548
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.73461113
45skeletal muscle adaptation (GO:0043501)3.72033267
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71628049
47actin filament-based movement (GO:0030048)3.56138574
48cardiac muscle tissue morphogenesis (GO:0055008)3.52568502
49* cardiac cell development (GO:0055006)3.49794704
50skeletal muscle tissue development (GO:0007519)3.49317386
51cardiac muscle cell action potential (GO:0086001)3.46553011
52negative regulation of protein localization to cell surface (GO:2000009)3.43700319
53cardiac muscle cell action potential involved in contraction (GO:0086002)3.42955372
54regulation of sarcomere organization (GO:0060297)3.42814681
55detection of calcium ion (GO:0005513)3.39686638
56regulation of the force of heart contraction (GO:0002026)3.39623398
57muscle cell fate commitment (GO:0042693)3.39105441
58cardiac conduction (GO:0061337)3.36249740
59skeletal muscle contraction (GO:0003009)3.34929648
60* muscle organ development (GO:0007517)3.34907074
61positive regulation of potassium ion transmembrane transport (GO:1901381)3.32221660
62* muscle structure development (GO:0061061)3.31364685
63muscle hypertrophy (GO:0014896)3.30804738
64positive regulation of cation channel activity (GO:2001259)3.29790346
65response to inactivity (GO:0014854)3.29270670
66regulation of cardiac muscle contraction (GO:0055117)3.27506887
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27263916
68locomotory exploration behavior (GO:0035641)3.26706609
69ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.26214757
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.23527052
71positive regulation of myotube differentiation (GO:0010831)3.23243532
72negative regulation of potassium ion transport (GO:0043267)3.23109695
73muscle tissue morphogenesis (GO:0060415)3.21693511
74potassium ion import (GO:0010107)3.19227904
75vocalization behavior (GO:0071625)3.18500097
76regulation of cardiac muscle cell contraction (GO:0086004)3.18307839
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18091247
78synaptic vesicle maturation (GO:0016188)3.17956991
79membrane depolarization during action potential (GO:0086010)3.17702840
80* striated muscle cell development (GO:0055002)3.17309404
81muscle cell cellular homeostasis (GO:0046716)3.15824822
82relaxation of cardiac muscle (GO:0055119)3.15691890
83regulation of cation channel activity (GO:2001257)3.15018055
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14104756
85regulation of heart rate by cardiac conduction (GO:0086091)3.13819857
86tricarboxylic acid cycle (GO:0006099)3.13083068
87glycogen catabolic process (GO:0005980)3.12940215
88carnitine shuttle (GO:0006853)3.12735255
89regulation of heart rate (GO:0002027)3.12052047
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.11780364
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.11098981
92regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10171094
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09675710
94regulation of skeletal muscle cell differentiation (GO:2001014)3.09000821
95heart trabecula formation (GO:0060347)3.08838673
96myoblast fusion (GO:0007520)3.08668994
97neuronal action potential propagation (GO:0019227)3.06713568
98muscle contraction (GO:0006936)3.05591206
99regulation of heart contraction (GO:0008016)3.02632207
100regulation of voltage-gated calcium channel activity (GO:1901385)3.00471360
101cardiac chamber formation (GO:0003207)2.99486401
102sodium ion export (GO:0071436)2.97108640
103regulation of acyl-CoA biosynthetic process (GO:0050812)2.96017867
104activation of protein kinase A activity (GO:0034199)2.93446477
105cardiac muscle adaptation (GO:0014887)2.92321344
106cardiac muscle hypertrophy in response to stress (GO:0014898)2.92321344
107muscle hypertrophy in response to stress (GO:0003299)2.92321344
108glucan biosynthetic process (GO:0009250)2.91979032
109glycogen biosynthetic process (GO:0005978)2.91979032
110negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.90958308
111negative regulation of calcium ion transmembrane transport (GO:1903170)2.90958308
112regulation of muscle system process (GO:0090257)2.88826676
113regulation of myoblast differentiation (GO:0045661)2.88335893
114glucan catabolic process (GO:0009251)2.87729693
115regulation of glutamate receptor signaling pathway (GO:1900449)2.87395783
116relaxation of muscle (GO:0090075)2.87165648
117regulation of muscle contraction (GO:0006937)2.86535400
118muscle system process (GO:0003012)2.85184686
119cardiac ventricle formation (GO:0003211)2.83518306
120* muscle cell development (GO:0055001)2.82666914
121striated muscle tissue development (GO:0014706)2.81539068
122positive regulation of ion transmembrane transporter activity (GO:0032414)2.81329980
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78383489
124syncytium formation by plasma membrane fusion (GO:0000768)2.77557441
125positive regulation of potassium ion transport (GO:0043268)2.77286194
126regulation of potassium ion transmembrane transport (GO:1901379)2.77060414
127muscle adaptation (GO:0043500)2.76772076
128NADH metabolic process (GO:0006734)2.76239699
129striated muscle atrophy (GO:0014891)2.75938246
130synaptic vesicle docking involved in exocytosis (GO:0016081)2.75799027
131regulation of cofactor metabolic process (GO:0051193)2.73330882
132regulation of coenzyme metabolic process (GO:0051196)2.73330882
133regulation of potassium ion transmembrane transporter activity (GO:1901016)2.72059081
134striated muscle adaptation (GO:0014888)2.71924871
135neuromuscular junction development (GO:0007528)2.70807795
136metanephric mesenchyme development (GO:0072075)2.69492497
137regulation of ATPase activity (GO:0043462)2.68118437
138regulation of ATP catabolic process (GO:1903289)2.68118437
139muscle tissue development (GO:0060537)2.64022752
140cellular polysaccharide catabolic process (GO:0044247)2.64000024
141positive regulation of myoblast differentiation (GO:0045663)2.63851350
142cell-substrate adherens junction assembly (GO:0007045)2.62903356
143focal adhesion assembly (GO:0048041)2.62903356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26419668
2DROSHA_22980978_ChIP-Seq_HELA_Human2.74882252
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73891780
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58563077
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54793304
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54793304
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.48067630
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46230807
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.31787638
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.31687059
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29236637
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27047861
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.20968057
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19796547
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11992038
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11890896
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09668771
18GBX2_23144817_ChIP-Seq_PC3_Human2.04929057
19* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.00828218
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99091049
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98383844
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97553804
23* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90917589
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85321214
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.82141363
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.80591270
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.78019769
28TBX20_22080862_ChIP-Seq_HEART_Mouse1.78019769
29* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75693252
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.66564558
31REST_21632747_ChIP-Seq_MESCs_Mouse1.62701087
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61657637
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60759939
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51054053
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50734977
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47798756
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.46459438
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46048934
39AR_21572438_ChIP-Seq_LNCaP_Human1.45690728
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44037581
41KDM2B_26808549_Chip-Seq_K562_Human1.39862818
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36865444
43* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36583477
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35547446
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34291280
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34106236
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28409947
48SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27942111
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27834854
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26728979
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.26645168
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23679000
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23170686
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22839162
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22538933
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.21969765
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.21634449
58CTCF_27219007_Chip-Seq_Bcells_Human1.21307505
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20201541
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20115426
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.20055755
62ZNF274_21170338_ChIP-Seq_K562_Hela1.19235180
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19148281
64* TET1_21490601_ChIP-Seq_MESCs_Mouse1.18034589
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.17660310
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15766101
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.15729958
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15572762
69SMAD4_21799915_ChIP-Seq_A2780_Human1.14908650
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14397909
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14186741
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14138165
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12993399
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11346790
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11027300
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.11009126
77CLOCK_20551151_ChIP-Seq_293T_Human1.09826491
78AR_19668381_ChIP-Seq_PC3_Human1.09677594
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08136802
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.07855766
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07811159
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07708415
83RACK7_27058665_Chip-Seq_MCF-7_Human1.06388199
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05925669
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05871130
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05122369
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04075641
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03918069
89SMC4_20622854_ChIP-Seq_HELA_Human1.03765693
90MYC_27129775_Chip-Seq_CORNEA_Mouse1.03714219
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.02000860
92AHR_22903824_ChIP-Seq_MCF-7_Human1.01942426
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01685631
94KDM2B_26808549_Chip-Seq_DND41_Human0.99820680
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99471655
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99467231
97TP53_16413492_ChIP-PET_HCT116_Human0.99273735
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98797179
99ZNF263_19887448_ChIP-Seq_K562_Human0.98311764
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98025368
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.97471475
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97401258
103GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96628002
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95967740
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94949013
106* LXR_22292898_ChIP-Seq_THP-1_Human0.94723630
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94540124
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94344851
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94334043
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94237053
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.93042098
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93032233
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.92515392
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.91954649
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91270969
116* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91057994
117CREB1_26743006_Chip-Seq_LNCaP_Human0.89557112
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.89257746
119SMAD3_21741376_ChIP-Seq_EPCs_Human0.89208932
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88085243
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86919385
122* TP63_22573176_ChIP-Seq_HFKS_Human0.86603216
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.86594102
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.86567291
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86046208
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85695883
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83950668
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83749162
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83374828
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.83144205
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83086434
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82977338
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81884457
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81437652
135KLF4_19829295_ChIP-Seq_ESCs_Human0.80770210
136* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78972244
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78019719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.35124566
2MP0000751_myopathy5.15546432
3MP0003646_muscle_fatigue4.75854914
4MP0004084_abnormal_cardiac_muscle4.16766388
5MP0004215_abnormal_myocardial_fiber3.80900906
6MP0000749_muscle_degeneration3.75763820
7MP0004036_abnormal_muscle_relaxation3.60963254
8MP0004859_abnormal_synaptic_plasticity3.51913703
9MP0004145_abnormal_muscle_electrophysio3.45464886
10MP0005330_cardiomyopathy2.88553628
11MP0004087_abnormal_muscle_fiber2.68984261
12MP0003137_abnormal_impulse_conducting2.53278581
13MP0002106_abnormal_muscle_physiology2.46417023
14* MP0005620_abnormal_muscle_contractility2.44748623
15MP0000750_abnormal_muscle_regeneration2.35485917
16* MP0002972_abnormal_cardiac_muscle2.35168686
17MP0008438_abnormal_cutaneous_collagen2.25244342
18MP0000747_muscle_weakness2.23583571
19MP0002822_catalepsy2.20969686
20MP0004510_myositis2.16041556
21MP0004484_altered_response_of2.11943864
22MP0004130_abnormal_muscle_cell2.11818506
23MP0008775_abnormal_heart_ventricle2.11259839
24MP0002269_muscular_atrophy2.11203037
25MP0005369_muscle_phenotype2.05924361
26MP0000759_abnormal_skeletal_muscle2.03024619
27MP0003635_abnormal_synaptic_transmissio2.00321910
28MP0004085_abnormal_heartbeat1.92183906
29MP0001544_abnormal_cardiovascular_syste1.89954972
30MP0005385_cardiovascular_system_phenoty1.89954972
31MP0010630_abnormal_cardiac_muscle1.88377319
32MP0004233_abnormal_muscle_weight1.87627905
33MP0003880_abnormal_central_pattern1.86521926
34MP0003705_abnormal_hypodermis_morpholog1.77158758
35MP0004270_analgesia1.76729490
36MP0006138_congestive_heart_failure1.76610257
37MP0005451_abnormal_body_composition1.71410532
38MP0005503_abnormal_tendon_morphology1.65305945
39MP0009745_abnormal_behavioral_response1.59910387
40MP0009046_muscle_twitch1.58349511
41MP0009384_cardiac_valve_regurgitation1.52812614
42MP0002063_abnormal_learning/memory/cond1.47531699
43MP0001958_emphysema1.46712930
44MP0002064_seizures1.42758090
45MP0010030_abnormal_orbit_morphology1.36047307
46MP0005623_abnormal_meninges_morphology1.35126486
47MP0003828_pulmonary_edema1.31795676
48MP0008569_lethality_at_weaning1.29472790
49MP0005275_abnormal_skin_tensile1.23653951
50MP0002909_abnormal_adrenal_gland1.22342357
51MP0002332_abnormal_exercise_endurance1.20572772
52MP0002272_abnormal_nervous_system1.20309346
53MP0002127_abnormal_cardiovascular_syste1.16365478
54MP0002572_abnormal_emotion/affect_behav1.14532417
55MP0003221_abnormal_cardiomyocyte_apopto1.14167632
56MP0001486_abnormal_startle_reflex1.12654494
57MP0004272_abnormal_basement_membrane1.11930281
58MP0002234_abnormal_pharynx_morphology1.04703605
59MP0002108_abnormal_muscle_morphology1.03255662
60MP0009780_abnormal_chondrocyte_physiolo1.02411605
61MP0004858_abnormal_nervous_system1.01209699
62MP0001440_abnormal_grooming_behavior1.01155945
63MP0003950_abnormal_plasma_membrane0.98619952
64MP0000013_abnormal_adipose_tissue0.96357133
65MP0004924_abnormal_behavior0.96112457
66MP0005386_behavior/neurological_phenoty0.96112457
67MP0001968_abnormal_touch/_nociception0.95496781
68MP0002734_abnormal_mechanical_nocicepti0.94359331
69MP0005423_abnormal_somatic_nervous0.89253559
70MP0002067_abnormal_sensory_capabilities0.88501803
71MP0005666_abnormal_adipose_tissue0.86132607
72MP0002249_abnormal_larynx_morphology0.86116534
73MP0001661_extended_life_span0.85973228
74MP0000767_abnormal_smooth_muscle0.83641362
75MP0001501_abnormal_sleep_pattern0.82091274
76MP0002735_abnormal_chemical_nociception0.82082729
77MP0008961_abnormal_basal_metabolism0.81821365
78MP0003279_aneurysm0.81035629
79MP0000534_abnormal_ureter_morphology0.77414981
80MP0006036_abnormal_mitochondrial_physio0.76546250
81MP0003879_abnormal_hair_cell0.76125008
82MP0009250_abnormal_appendicular_skeleto0.75716758
83MP0000733_abnormal_muscle_development0.74975963
84MP0005165_increased_susceptibility_to0.74533312
85* MP0000266_abnormal_heart_morphology0.74455975
86MP0005375_adipose_tissue_phenotype0.74427571
87MP0000762_abnormal_tongue_morphology0.73607770
88MP0005167_abnormal_blood-brain_barrier0.72746250
89MP0001970_abnormal_pain_threshold0.71246976
90MP0002066_abnormal_motor_capabilities/c0.71010164
91MP0000230_abnormal_systemic_arterial0.70626387
92MP0004811_abnormal_neuron_physiology0.70202890
93MP0002184_abnormal_innervation0.69492372
94MP0003633_abnormal_nervous_system0.69471131
95MP0002971_abnormal_brown_adipose0.69186263
96MP0003329_amyloid_beta_deposits0.68953136
97MP0001849_ear_inflammation0.67576882
98MP0004134_abnormal_chest_morphology0.66054800
99MP0005266_abnormal_metabolism0.65705544
100MP0002896_abnormal_bone_mineralization0.65643257
101MP0003385_abnormal_body_wall0.64709640
102MP0004185_abnormal_adipocyte_glucose0.64604656
103MP0005670_abnormal_white_adipose0.63836254
104MP0003045_fibrosis0.63082803
105MP0001502_abnormal_circadian_rhythm0.63055502
106MP0001348_abnormal_lacrimal_gland0.62269695
107MP0005595_abnormal_vascular_smooth0.60922307
108MP0010368_abnormal_lymphatic_system0.60467882
109MP0000579_abnormal_nail_morphology0.60370153
110MP0000462_abnormal_digestive_system0.59733459
111MP0002114_abnormal_axial_skeleton0.59645049
112MP0000003_abnormal_adipose_tissue0.59521258
113MP0002736_abnormal_nociception_after0.59093642
114MP0002557_abnormal_social/conspecific_i0.58667537
115MP0003566_abnormal_cell_adhesion0.58360248
116MP0000343_altered_response_to0.57821733
117MP0008874_decreased_physiological_sensi0.57611478
118MP0003283_abnormal_digestive_organ0.55818395
119MP0006035_abnormal_mitochondrial_morpho0.55676729
120MP0002882_abnormal_neuron_morphology0.55519202
121MP0002733_abnormal_thermal_nociception0.55014396
122MP0001299_abnormal_eye_distance/0.54626804
123MP0003075_altered_response_to0.54173292
124MP0005409_darkened_coat_color0.53566514
125MP0000955_abnormal_spinal_cord0.53099097
126MP0005535_abnormal_body_temperature0.52039600
127MP0002128_abnormal_blood_circulation0.51077165
128MP0005508_abnormal_skeleton_morphology0.49833830
129MP0003631_nervous_system_phenotype0.49029278
130MP0003942_abnormal_urinary_system0.48821141
131MP0005257_abnormal_intraocular_pressure0.47409003
132MP0003091_abnormal_cell_migration0.45166710
133MP0001542_abnormal_bone_strength0.40280114
134MP0002116_abnormal_craniofacial_bone0.40093514
135MP0000049_abnormal_middle_ear0.38390804

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.27758478
2Exercise-induced myalgia (HP:0003738)6.10343718
3Calf muscle hypertrophy (HP:0008981)6.01715548
4Muscle hypertrophy of the lower extremities (HP:0008968)5.83163555
5Exercise-induced muscle cramps (HP:0003710)5.69883831
6Muscle fiber splitting (HP:0003555)5.39176089
7Abnormality of the calf musculature (HP:0001430)5.17656621
8Atrial fibrillation (HP:0005110)5.15467187
9Ventricular tachycardia (HP:0004756)4.93793296
10Primary atrial arrhythmia (HP:0001692)4.87800746
11Hyporeflexia of lower limbs (HP:0002600)4.68215776
12Supraventricular tachycardia (HP:0004755)4.66959718
13Abnormality of the left ventricular outflow tract (HP:0011103)4.61032600
14Subaortic stenosis (HP:0001682)4.61032600
15Supraventricular arrhythmia (HP:0005115)4.57558577
16Bundle branch block (HP:0011710)4.44527239
17Prolonged QT interval (HP:0001657)4.36990320
18EMG: myopathic abnormalities (HP:0003458)4.34125004
19Syncope (HP:0001279)4.31089013
20Difficulty running (HP:0009046)4.14721339
21Myotonia (HP:0002486)3.95247787
22Type 1 muscle fiber predominance (HP:0003803)3.93744272
23Lipoatrophy (HP:0100578)3.92901300
24Ventricular fibrillation (HP:0001663)3.88788118
25Myoglobinuria (HP:0002913)3.82080872
26Calcaneovalgus deformity (HP:0001848)3.79963357
27Increased connective tissue (HP:0009025)3.79733197
28Muscle fiber inclusion bodies (HP:0100299)3.78640958
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.70958465
30Ventricular arrhythmia (HP:0004308)3.68369427
31Right ventricular cardiomyopathy (HP:0011663)3.63053034
32Heart block (HP:0012722)3.60668007
33Asymmetric septal hypertrophy (HP:0001670)3.48344055
34Abnormal EKG (HP:0003115)3.43078747
35Abnormal atrioventricular conduction (HP:0005150)3.39540873
36Deformed tarsal bones (HP:0008119)3.39339419
37Atrioventricular block (HP:0001678)3.35407174
38Difficulty climbing stairs (HP:0003551)3.21001738
39Focal motor seizures (HP:0011153)3.20232005
40Increased variability in muscle fiber diameter (HP:0003557)3.15927825
41* Dilated cardiomyopathy (HP:0001644)3.14307634
42Absent phalangeal crease (HP:0006109)3.02610637
43Myokymia (HP:0002411)2.99792296
44Palpitations (HP:0001962)2.98622953
45Nemaline bodies (HP:0003798)2.96985608
46Abnormality of skeletal muscle fiber size (HP:0012084)2.95729634
47Distal lower limb amyotrophy (HP:0008944)2.83417175
48Dysmetric saccades (HP:0000641)2.73797505
49Lower limb amyotrophy (HP:0007210)2.69377845
50Slender build (HP:0001533)2.66099890
51Abnormality of the calcaneus (HP:0008364)2.63429841
52Muscle stiffness (HP:0003552)2.61585759
53Round ear (HP:0100830)2.54761184
54Rhabdomyolysis (HP:0003201)2.53195617
55Malignant hyperthermia (HP:0002047)2.51523531
56Neck muscle weakness (HP:0000467)2.50671377
57Mildly elevated creatine phosphokinase (HP:0008180)2.50637369
58Left ventricular hypertrophy (HP:0001712)2.50432304
59Abnormal finger flexion creases (HP:0006143)2.42894300
60Fetal akinesia sequence (HP:0001989)2.40625583
61Distal arthrogryposis (HP:0005684)2.37323665
62Testicular atrophy (HP:0000029)2.35154200
63Focal seizures (HP:0007359)2.35079487
64Protrusio acetabuli (HP:0003179)2.34818082
65Bulbar palsy (HP:0001283)2.30146084
66Visual hallucinations (HP:0002367)2.28302370
67EMG: neuropathic changes (HP:0003445)2.27511496
68Aortic aneurysm (HP:0004942)2.22754709
69Abnormality of the foot musculature (HP:0001436)2.21637955
70Scapular winging (HP:0003691)2.21336093
71Myopathic facies (HP:0002058)2.21291651
72Limb-girdle muscle atrophy (HP:0003797)2.17931935
73* Hip contracture (HP:0003273)2.17546586
74Muscular dystrophy (HP:0003560)2.17491887
75Obstructive sleep apnea (HP:0002870)2.16030152
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.14960116
77Premature rupture of membranes (HP:0001788)2.14757229
78Gowers sign (HP:0003391)2.14188209
79Rapidly progressive (HP:0003678)2.12765331
80Foot dorsiflexor weakness (HP:0009027)2.12075248
81Distal lower limb muscle weakness (HP:0009053)2.11845438
82Areflexia of lower limbs (HP:0002522)2.09504999
83Waddling gait (HP:0002515)2.03386280
84Hypoplastic ischia (HP:0003175)2.02990260
85Frequent falls (HP:0002359)2.02202696
86Stridor (HP:0010307)1.98714318
87Rimmed vacuoles (HP:0003805)1.96717849
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95797202
89Proximal amyotrophy (HP:0007126)1.95263743
90Broad-based gait (HP:0002136)1.94417953
91Weak cry (HP:0001612)1.93430095
92Broad metatarsal (HP:0001783)1.91327862
93Facial diplegia (HP:0001349)1.86808436
94Generalized muscle weakness (HP:0003324)1.84382548
95Action tremor (HP:0002345)1.84005276
96Cerebral aneurysm (HP:0004944)1.81874250
97Poor eye contact (HP:0000817)1.81758690
98Palmoplantar keratoderma (HP:0000982)1.81592696
99Pheochromocytoma (HP:0002666)1.79083873
100Dysdiadochokinesis (HP:0002075)1.78849717
101Sudden cardiac death (HP:0001645)1.78560170
102Metatarsus adductus (HP:0001840)1.77720842
103Aortic dissection (HP:0002647)1.76255458
104Hyperkalemia (HP:0002153)1.72238267
105Abnormality of the ischium (HP:0003174)1.70236432
106Anxiety (HP:0000739)1.70067125
107Abnormal social behavior (HP:0012433)1.69795010
108Impaired social interactions (HP:0000735)1.69795010
109Depression (HP:0000716)1.69572864
110Infantile muscular hypotonia (HP:0008947)1.68264616
111Bradycardia (HP:0001662)1.67861086
112Respiratory insufficiency due to muscle weakness (HP:0002747)1.67487934
113* Limited hip movement (HP:0008800)1.67109722
114Central scotoma (HP:0000603)1.66433484
115Congestive heart failure (HP:0001635)1.64736230
116Generalized tonic-clonic seizures (HP:0002069)1.64565346
117Shallow orbits (HP:0000586)1.63705327
118Progressive cerebellar ataxia (HP:0002073)1.59878172
119Abnormality of the shoulder girdle musculature (HP:0001435)1.59051855
120Febrile seizures (HP:0002373)1.58844160
121Thin ribs (HP:0000883)1.58560262
122Spinal rigidity (HP:0003306)1.56759585
123Limb-girdle muscle weakness (HP:0003325)1.56758560
124Ulnar deviation of the wrist (HP:0003049)1.56441668
125Fatigable weakness (HP:0003473)1.55143371
126Abnormality of the neuromuscular junction (HP:0003398)1.55143371
127Generalized amyotrophy (HP:0003700)1.54091166
128Atrophic scars (HP:0001075)1.52128148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.52257422
2OBSCN4.30670965
3PHKG13.87113353
4PHKG23.87113353
5EPHA42.92947501
6DMPK2.85506835
7LMTK22.56576610
8MUSK2.49301746
9NTRK32.26162552
10MYLK2.16121930
11TRIB32.04807202
12PINK11.94526342
13MAP3K91.72793479
14PRKD31.71589150
15PAK61.62941337
16STK381.61811969
17DAPK21.61314167
18PDK41.60718444
19PDK31.60718444
20PKN21.57445463
21NEK11.55295703
22PIK3CA1.43637603
23RIPK11.41425542
24EEF2K1.41094018
25MAP3K41.37098941
26CAMKK11.34711904
27TRPM71.31308889
28KSR21.30163990
29MAP3K71.29754980
30LIMK11.28058691
31DDR21.26893218
32MAP2K61.19197949
33MAPKAPK31.18414033
34PAK31.18149287
35CAMK2D1.12144380
36MAPK121.09458834
37MAP2K41.09067792
38PTK2B1.08940270
39MINK11.07490283
40SIK11.06390209
41CAMK11.05253533
42MAP3K61.05196837
43TIE11.04714739
44TNIK1.04551293
45MARK11.03289842
46PRKD11.01083368
47TAOK10.97766781
48CDC42BPA0.96476767
49PTK20.96278139
50CAMK2A0.93242725
51ROCK10.91076130
52NME10.90057088
53CAMKK20.89221221
54RIPK40.88084833
55MAPK70.87552507
56CDK50.86204818
57DAPK30.84464374
58WNK10.83135557
59MOS0.83103129
60SIK20.82489520
61NTRK10.82416677
62PRKCH0.82301193
63CAMK40.81368438
64PDK20.80725436
65NTRK20.77166427
66PDGFRA0.77049559
67RPS6KA20.75765033
68PRPF4B0.74503371
69NEK90.74233748
70MAP2K70.72437172
71MAPK150.70148374
72MET0.70144553
73DYRK1B0.70132224
74ILK0.69867324
75STK110.69813702
76CAMK1G0.68709322
77PKN10.67971976
78INSRR0.67484038
79SGK10.66826151
80KSR10.66213065
81PRKAA10.65587634
82LATS20.64531375
83STK240.64301986
84WNK40.64204589
85PDPK10.62019935
86MTOR0.61836079
87EPHB10.61173574
88SGK30.60048411
89MAP3K50.59764069
90PAK20.59410302
91MARK20.59312421
92MAPK40.58388863
93ROCK20.56923294
94FES0.54923746
95PDK10.53612016
96PRKCE0.52749699
97RPS6KC10.52446882
98RPS6KL10.52446882
99GRK70.52353251
100MAP3K10.51620642
101PRKD20.51451018
102MAP3K130.51344972
103TESK10.50539117
104RET0.50322467
105PRKAA20.49734863
106CAMK2G0.49583158
107MAP2K30.49565798
108PIK3CG0.49533227
109RPS6KA30.47634916
110UHMK10.47205403
111PRKACB0.46673181
112EPHB20.46161656
113FLT30.46144328
114PRKG10.44971997
115MAP2K10.44823769
116PRKCG0.44798357
117AKT20.44543797
118SGK20.44406424
119DAPK10.43566596
120CAMK2B0.43463754
121RPS6KA60.42605371
122GRK50.42009921
123LATS10.41662981
124PRKACA0.41071311
125MAPK100.39767440
126DYRK1A0.39718961
127SGK4940.38242539
128SGK2230.38242539
129ICK0.38041709
130BCKDK0.35557087
131TYRO30.35525422
132FER0.34928752
133PDGFRB0.34272014
134MAPK110.29671428
135STK38L0.26738079
136MAPK130.26043454

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.35026060
2Cardiac muscle contraction_Homo sapiens_hsa042603.32668418
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.08956725
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.68628922
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41425479
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.41373294
7Circadian entrainment_Homo sapiens_hsa047132.09847028
8Olfactory transduction_Homo sapiens_hsa047402.02923490
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84037763
10Oxytocin signaling pathway_Homo sapiens_hsa049211.84031551
11Nicotine addiction_Homo sapiens_hsa050331.83122914
12Calcium signaling pathway_Homo sapiens_hsa040201.79207248
13Long-term potentiation_Homo sapiens_hsa047201.74614900
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70033195
15Morphine addiction_Homo sapiens_hsa050321.68073868
16Glutamatergic synapse_Homo sapiens_hsa047241.67428676
17Gastric acid secretion_Homo sapiens_hsa049711.66831939
18GABAergic synapse_Homo sapiens_hsa047271.65447681
19Insulin secretion_Homo sapiens_hsa049111.62214249
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60405169
21Salivary secretion_Homo sapiens_hsa049701.54723443
22Renin secretion_Homo sapiens_hsa049241.52946561
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.51787069
24Amphetamine addiction_Homo sapiens_hsa050311.51633490
25Synaptic vesicle cycle_Homo sapiens_hsa047211.51470590
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50625787
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48801050
28Cholinergic synapse_Homo sapiens_hsa047251.47183821
29Parkinsons disease_Homo sapiens_hsa050121.35557619
30Type II diabetes mellitus_Homo sapiens_hsa049301.34852999
31Dopaminergic synapse_Homo sapiens_hsa047281.32549488
32Alzheimers disease_Homo sapiens_hsa050101.28759957
33GnRH signaling pathway_Homo sapiens_hsa049121.28376952
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.25165198
35cAMP signaling pathway_Homo sapiens_hsa040241.22302104
36Oxidative phosphorylation_Homo sapiens_hsa001901.19714185
37Taste transduction_Homo sapiens_hsa047421.13581347
38Arginine and proline metabolism_Homo sapiens_hsa003301.11386192
39Gap junction_Homo sapiens_hsa045401.07088198
40Glucagon signaling pathway_Homo sapiens_hsa049221.06693945
41Viral myocarditis_Homo sapiens_hsa054160.99149048
42Cocaine addiction_Homo sapiens_hsa050300.98598997
43Arginine biosynthesis_Homo sapiens_hsa002200.98564566
44Long-term depression_Homo sapiens_hsa047300.98546238
45Insulin signaling pathway_Homo sapiens_hsa049100.94867726
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94133391
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93294992
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91763389
49Protein digestion and absorption_Homo sapiens_hsa049740.91568751
50Serotonergic synapse_Homo sapiens_hsa047260.90904229
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88315303
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85871494
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84933751
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84915713
55Fructose and mannose metabolism_Homo sapiens_hsa000510.83990797
56Melanogenesis_Homo sapiens_hsa049160.82603054
57Pentose phosphate pathway_Homo sapiens_hsa000300.82078641
58Focal adhesion_Homo sapiens_hsa045100.82078019
59Estrogen signaling pathway_Homo sapiens_hsa049150.81168836
60Propanoate metabolism_Homo sapiens_hsa006400.81064603
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80043259
62Insulin resistance_Homo sapiens_hsa049310.78889242
63Glioma_Homo sapiens_hsa052140.78783268
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.76134345
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.75820354
66Carbon metabolism_Homo sapiens_hsa012000.75078599
67Circadian rhythm_Homo sapiens_hsa047100.75053485
68VEGF signaling pathway_Homo sapiens_hsa043700.72478741
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71746552
70Pancreatic secretion_Homo sapiens_hsa049720.71451928
71Dorso-ventral axis formation_Homo sapiens_hsa043200.70719446
72Huntingtons disease_Homo sapiens_hsa050160.70108505
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68551727
74HIF-1 signaling pathway_Homo sapiens_hsa040660.67475841
75Axon guidance_Homo sapiens_hsa043600.67264355
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65894591
77Tight junction_Homo sapiens_hsa045300.65799380
78MAPK signaling pathway_Homo sapiens_hsa040100.64254269
79Notch signaling pathway_Homo sapiens_hsa043300.63916868
80Lysine degradation_Homo sapiens_hsa003100.63024012
81mTOR signaling pathway_Homo sapiens_hsa041500.58639773
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58418387
83AMPK signaling pathway_Homo sapiens_hsa041520.57924809
84Bile secretion_Homo sapiens_hsa049760.56905263
85Hippo signaling pathway_Homo sapiens_hsa043900.55311604
86Rap1 signaling pathway_Homo sapiens_hsa040150.54951283
87Hedgehog signaling pathway_Homo sapiens_hsa043400.54804211
88Amoebiasis_Homo sapiens_hsa051460.54509329
89ErbB signaling pathway_Homo sapiens_hsa040120.53613475
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53009105
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52811088
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52291895
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52153198
94Biosynthesis of amino acids_Homo sapiens_hsa012300.51778109
95Fatty acid degradation_Homo sapiens_hsa000710.50905664
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.49810698
97Basal cell carcinoma_Homo sapiens_hsa052170.49566930
98Platelet activation_Homo sapiens_hsa046110.47827102
99Renal cell carcinoma_Homo sapiens_hsa052110.47293962
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.46498273
101Pyruvate metabolism_Homo sapiens_hsa006200.45923801
102FoxO signaling pathway_Homo sapiens_hsa040680.45384533
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45260855
104Proteoglycans in cancer_Homo sapiens_hsa052050.44879145
105ECM-receptor interaction_Homo sapiens_hsa045120.44061458
106Collecting duct acid secretion_Homo sapiens_hsa049660.43887948
107Other glycan degradation_Homo sapiens_hsa005110.43725728
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.42929911
109Inositol phosphate metabolism_Homo sapiens_hsa005620.42663187
110Fatty acid metabolism_Homo sapiens_hsa012120.41593287
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41050483
112Choline metabolism in cancer_Homo sapiens_hsa052310.40625486
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39531869
114PPAR signaling pathway_Homo sapiens_hsa033200.39212558
115Ovarian steroidogenesis_Homo sapiens_hsa049130.38934634
116Ras signaling pathway_Homo sapiens_hsa040140.38817650
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38058560
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37813949
119Endometrial cancer_Homo sapiens_hsa052130.37626901
120Thyroid hormone synthesis_Homo sapiens_hsa049180.37613307
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37337741
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35856998
123Adherens junction_Homo sapiens_hsa045200.33880445

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