SPEN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.84400026
2positive regulation of histone deacetylation (GO:0031065)4.63837600
3histone H3-K4 trimethylation (GO:0080182)4.30156807
4monoubiquitinated protein deubiquitination (GO:0035520)4.16123478
5histone H3-K4 methylation (GO:0051568)4.06931433
6cytoplasmic mRNA processing body assembly (GO:0033962)4.03996611
7histone H3-K36 demethylation (GO:0070544)3.87962491
8regulation of histone H3-K27 methylation (GO:0061085)3.84099680
9intracellular estrogen receptor signaling pathway (GO:0030520)3.77195845
10regulation of NFAT protein import into nucleus (GO:0051532)3.69955211
11negative regulation of erythrocyte differentiation (GO:0045647)3.60805135
12positive regulation by host of viral transcription (GO:0043923)3.58939548
13histone H4-K12 acetylation (GO:0043983)3.53740140
14positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.52221977
15positive regulation of gene expression, epigenetic (GO:0045815)3.50908124
16mitotic chromosome condensation (GO:0007076)3.49825423
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45367122
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.45367122
19regulation of translation, ncRNA-mediated (GO:0045974)3.45367122
20interkinetic nuclear migration (GO:0022027)3.42470171
21glucocorticoid receptor signaling pathway (GO:0042921)3.40089103
22nuclear pore complex assembly (GO:0051292)3.37829629
23sister chromatid segregation (GO:0000819)3.33847998
24negative regulation of histone modification (GO:0031057)3.31433319
25histone lysine methylation (GO:0034968)3.29526656
26N-terminal protein amino acid acetylation (GO:0006474)3.27954028
27negative regulation of histone methylation (GO:0031061)3.26442888
28mitotic sister chromatid cohesion (GO:0007064)3.21803967
29mRNA stabilization (GO:0048255)3.20150378
30RNA stabilization (GO:0043489)3.20150378
31negative regulation of gene expression, epigenetic (GO:0045814)3.12190973
32positive regulation of protein deacetylation (GO:0090312)3.11244016
33mitotic sister chromatid segregation (GO:0000070)3.10209562
34definitive hemopoiesis (GO:0060216)3.09384077
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.09255317
36heterochromatin organization (GO:0070828)3.08538316
37peripheral nervous system neuron development (GO:0048935)3.06254914
38regulation of RNA export from nucleus (GO:0046831)3.06204450
39NLS-bearing protein import into nucleus (GO:0006607)3.04206466
40negative regulation of chromatin modification (GO:1903309)3.03778506
41peptidyl-lysine trimethylation (GO:0018023)3.02868152
42nuclear pore organization (GO:0006999)3.02139523
43histone H4-K16 acetylation (GO:0043984)3.00887412
44DNA duplex unwinding (GO:0032508)3.00061180
45DNA topological change (GO:0006265)2.97351986
46histone deubiquitination (GO:0016578)2.96922308
47sister chromatid cohesion (GO:0007062)2.94963694
48DNA unwinding involved in DNA replication (GO:0006268)2.87477865
49corticosteroid receptor signaling pathway (GO:0031958)2.87307892
50histone H3-K9 demethylation (GO:0033169)2.86274428
51dosage compensation (GO:0007549)2.85743568
52DNA synthesis involved in DNA repair (GO:0000731)2.84970668
53peptidyl-lysine dimethylation (GO:0018027)2.84386573
54DNA geometric change (GO:0032392)2.84199368
55apoptotic process involved in morphogenesis (GO:0060561)2.84015637
56histone lysine demethylation (GO:0070076)2.83592718
57embryonic camera-type eye morphogenesis (GO:0048596)2.79890491
58histone methylation (GO:0016571)2.79462183
59stress granule assembly (GO:0034063)2.77370267
60negative regulation of mRNA processing (GO:0050686)2.76716308
61histone H4-K5 acetylation (GO:0043981)2.76180030
62histone H4-K8 acetylation (GO:0043982)2.76180030
63protein-DNA complex disassembly (GO:0032986)2.73682242
64nucleosome disassembly (GO:0006337)2.73682242
65negative regulation of cell cycle G2/M phase transition (GO:1902750)2.72066803
66regulation of protein polyubiquitination (GO:1902914)2.71770555
67positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.71747593
68embryonic placenta development (GO:0001892)2.71325038
69positive thymic T cell selection (GO:0045059)2.70206784
70positive regulation of DNA-templated transcription, initiation (GO:2000144)2.70103054
71regulation of histone deacetylation (GO:0031063)2.68072260
723-UTR-mediated mRNA stabilization (GO:0070935)2.67214986
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.66412410
74histone modification (GO:0016570)2.66059497
75peptidyl-lysine acetylation (GO:0018394)2.64914826
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.64379545
77histone demethylation (GO:0016577)2.63653135
78positive regulation of RNA splicing (GO:0033120)2.63232361
79negative regulation of mRNA metabolic process (GO:1903312)2.62380614
80covalent chromatin modification (GO:0016569)2.62137795
81spliceosomal tri-snRNP complex assembly (GO:0000244)2.60802978
82histone H3-K9 methylation (GO:0051567)2.59683512
83peptidyl-lysine methylation (GO:0018022)2.59627402
84regulation of nucleobase-containing compound transport (GO:0032239)2.59562570
85regulation of histone H3-K9 methylation (GO:0051570)2.56472966
86histone H3-K9 modification (GO:0061647)2.55448096
87mRNA splice site selection (GO:0006376)2.54709375
88protein alkylation (GO:0008213)2.53894713
89protein methylation (GO:0006479)2.53894713
90internal protein amino acid acetylation (GO:0006475)2.52607697
91nucleus localization (GO:0051647)2.52482256
92coronary vasculature morphogenesis (GO:0060977)2.52259546
93DNA conformation change (GO:0071103)2.50960567
94positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49855202
95regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49855202
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.49715089
97gene silencing (GO:0016458)2.49350203
98regulation of histone H3-K4 methylation (GO:0051569)2.49140044
99trophectodermal cell differentiation (GO:0001829)2.49137348
100membrane disassembly (GO:0030397)2.48912079
101nuclear envelope disassembly (GO:0051081)2.48912079
102negative regulation of myotube differentiation (GO:0010832)2.48909387
103regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.46026006
104positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.46026006
105mitotic nuclear envelope disassembly (GO:0007077)2.44250943
106establishment of nucleus localization (GO:0040023)2.44039109
107regulation of translational fidelity (GO:0006450)2.44008404
108histone H3 deacetylation (GO:0070932)2.43956106
109regulation of integrin activation (GO:0033623)2.42888333
110phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42182204
111lymph vessel development (GO:0001945)2.40682039
112regulation of protein deacetylation (GO:0090311)2.40408829
113chromatin silencing (GO:0006342)2.40397873
114pore complex assembly (GO:0046931)2.40347866
115regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.39220970
116paraxial mesoderm development (GO:0048339)2.38777806
117histone H4 deacetylation (GO:0070933)2.38333362
118protein demethylation (GO:0006482)2.36958971
119protein dealkylation (GO:0008214)2.36958971
120heart morphogenesis (GO:0003007)2.36902520
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.36849578
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36268575
123negative regulation of cell killing (GO:0031342)2.36268575
124embryonic eye morphogenesis (GO:0048048)2.35847623
125histone H4 acetylation (GO:0043967)2.34871553
126histone H3 acetylation (GO:0043966)2.33577525
127head development (GO:0060322)2.32809270
128establishment of apical/basal cell polarity (GO:0035089)2.32249786
129peptidyl-threonine phosphorylation (GO:0018107)2.31590196
130regulation of mRNA stability (GO:0043488)2.31006537
131neural tube closure (GO:0001843)2.29784038
132adherens junction assembly (GO:0034333)2.29408236
133regulation of DNA endoreduplication (GO:0032875)2.29089210
134chromatin assembly (GO:0031497)2.28584109
135histone acetylation (GO:0016573)2.28107995
136gene silencing by RNA (GO:0031047)2.27874013
137hippo signaling (GO:0035329)2.26456588
138internal peptidyl-lysine acetylation (GO:0018393)2.26412063
139peptidyl-threonine modification (GO:0018210)2.25800803
140positive T cell selection (GO:0043368)2.24948781
141regulation of p38MAPK cascade (GO:1900744)2.24623055
142tube closure (GO:0060606)2.24000009
143establishment of spindle localization (GO:0051293)2.23928276
144rRNA catabolic process (GO:0016075)2.23846806
145branching involved in mammary gland duct morphogenesis (GO:0060444)2.22978750
146regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.22448575
147regulation of histone methylation (GO:0031060)2.22221741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.21167796
2E2F7_22180533_ChIP-Seq_HELA_Human3.51133719
3MYC_22102868_ChIP-Seq_BL_Human3.48401277
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37748610
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.37282260
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.99214605
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.84695676
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.84126498
9TCF7_22412390_ChIP-Seq_EML_Mouse2.77695249
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64963353
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64063791
12* KDM2B_26808549_Chip-Seq_DND41_Human2.63076152
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.44973992
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37495873
15* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.25418948
16VDR_21846776_ChIP-Seq_THP-1_Human2.18367867
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13470161
18* KDM2B_26808549_Chip-Seq_K562_Human2.02009405
19SCL_19346495_ChIP-Seq_HPC-7_Human1.99363540
20* KDM2B_26808549_Chip-Seq_JURKAT_Human1.96200709
21* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.88737059
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88429568
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83952243
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83521927
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83521927
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83521927
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79010408
28* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78330973
29* E2F1_21310950_ChIP-Seq_MCF-7_Human1.76592734
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75485445
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68371349
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.67656992
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.67020877
34KDM5A_27292631_Chip-Seq_BREAST_Human1.65666144
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56999071
36UTX_26944678_Chip-Seq_JUKART_Human1.55321263
37* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53756528
38GATA1_22025678_ChIP-Seq_K562_Human1.52358902
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.51253360
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49836647
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46983241
42* SPI1_23127762_ChIP-Seq_K562_Human1.46793966
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46493023
44CHD1_26751641_Chip-Seq_LNCaP_Human1.46472529
45* MAF_26560356_Chip-Seq_TH1_Human1.46205177
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45652031
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43855017
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43687784
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40674891
50LXR_22292898_ChIP-Seq_THP-1_Human1.40546657
51DROSHA_22980978_ChIP-Seq_HELA_Human1.39059501
52* MAF_26560356_Chip-Seq_TH2_Human1.38969192
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36704555
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36545207
55* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35566079
56NCOR1_26117541_ChIP-Seq_K562_Human1.34809980
57VDR_24763502_ChIP-Seq_THP-1_Human1.33088371
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32568783
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31914875
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29912559
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.29297425
62RACK7_27058665_Chip-Seq_MCF-7_Human1.28892197
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.28155504
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27619490
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27318518
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26124076
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25418026
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24382760
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20318167
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19892134
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.18883775
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17797245
73* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14901302
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14765548
75* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12726909
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11596939
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.11442559
78* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11168966
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09093919
80GATA1_19941826_ChIP-Seq_K562_Human1.08576895
81RUNX_20019798_ChIP-Seq_JUKART_Human1.08302525
82* TP53_22127205_ChIP-Seq_IMR90_Human1.07626778
83* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06719270
84* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06510869
85MYB_26560356_Chip-Seq_TH1_Human1.04856843
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04643185
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03020107
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02977634
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.02484944
90* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02367866
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01729681
92AR_21572438_ChIP-Seq_LNCaP_Human1.01718293
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.01665038
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.01253895
95* GATA6_25053715_ChIP-Seq_YYC3_Human1.00582156
96* CIITA_25753668_ChIP-Seq_RAJI_Human0.99496058
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99179500
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98679720
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98450268
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98119705
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97620611
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97129147
103* RARB_27405468_Chip-Seq_BRAIN_Mouse0.95437590
104SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95391441
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94937103
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94660545
107* RUNX1_22412390_ChIP-Seq_EML_Mouse0.93089523
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.92614544
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.92614544
110TP53_16413492_ChIP-PET_HCT116_Human0.92487109
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.92265119
112UBF1/2_26484160_Chip-Seq_HMECs_Human0.90868071
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90809819
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90791598
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90249002
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90216854
117AHR_22903824_ChIP-Seq_MCF-7_Human0.90137061
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89814382
119MYB_26560356_Chip-Seq_TH2_Human0.89521775
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.89437709
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88780498
122* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88562640
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88512251
124GATA2_19941826_ChIP-Seq_K562_Human0.88396132
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.87517852
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86274276
127* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83663488
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81903457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.29088080
2MP0005076_abnormal_cell_differentiation3.92891204
3MP0003705_abnormal_hypodermis_morpholog3.38548730
4MP0000569_abnormal_digit_pigmentation3.17063018
5MP0003300_gastrointestinal_ulcer3.09003369
6MP0009278_abnormal_bone_marrow3.01879270
7MP0010352_gastrointestinal_tract_polyps2.97265778
8MP0003787_abnormal_imprinting2.56456279
9MP0003303_peritoneal_inflammation2.51911550
10MP0008961_abnormal_basal_metabolism2.49529952
11MP0005409_darkened_coat_color2.24783002
12MP0002249_abnormal_larynx_morphology2.11984376
13MP0004264_abnormal_extraembryonic_tissu2.10816118
14MP0010307_abnormal_tumor_latency2.09383735
15MP0003045_fibrosis2.05252828
16MP0002396_abnormal_hematopoietic_system1.86442307
17MP0004197_abnormal_fetal_growth/weight/1.83347863
18MP0000733_abnormal_muscle_development1.80545835
19MP0004808_abnormal_hematopoietic_stem1.80405785
20MP0003566_abnormal_cell_adhesion1.76994286
21MP0005248_abnormal_Harderian_gland1.71048569
22MP0008057_abnormal_DNA_replication1.69181733
23MP0005670_abnormal_white_adipose1.65583586
24MP0004858_abnormal_nervous_system1.53961743
25MP0005397_hematopoietic_system_phenotyp1.52467797
26MP0001545_abnormal_hematopoietic_system1.52467797
27MP0001849_ear_inflammation1.52091325
28MP0002084_abnormal_developmental_patter1.51247980
29MP0004510_myositis1.48146502
30MP0002086_abnormal_extraembryonic_tissu1.46375032
31MP0005623_abnormal_meninges_morphology1.44459269
32MP0003283_abnormal_digestive_organ1.43460288
33MP0003111_abnormal_nucleus_morphology1.42490535
34MP0003984_embryonic_growth_retardation1.41011379
35MP0001672_abnormal_embryogenesis/_devel1.40852900
36MP0005380_embryogenesis_phenotype1.40852900
37MP0002088_abnormal_embryonic_growth/wei1.39838133
38MP0003941_abnormal_skin_development1.38676202
39* MP0002925_abnormal_cardiovascular_devel1.37452971
40MP0001346_abnormal_lacrimal_gland1.32211479
41MP0008058_abnormal_DNA_repair1.31767055
42MP0003943_abnormal_hepatobiliary_system1.29339358
43MP0010630_abnormal_cardiac_muscle1.28385750
44MP0002877_abnormal_melanocyte_morpholog1.28051003
45MP0002085_abnormal_embryonic_tissue1.27839767
46MP0003693_abnormal_embryo_hatching1.27533659
47MP0003172_abnormal_lysosome_physiology1.26175699
48MP0000383_abnormal_hair_follicle1.25765284
49MP0000566_synostosis1.25370662
50MP0003119_abnormal_digestive_system1.23935313
51MP0000703_abnormal_thymus_morphology1.23544537
52MP0005187_abnormal_penis_morphology1.22598549
53MP0000428_abnormal_craniofacial_morphol1.22031036
54MP0003935_abnormal_craniofacial_develop1.20740980
55MP0004381_abnormal_hair_follicle1.19626632
56MP0003890_abnormal_embryonic-extraembry1.18280234
57MP0009703_decreased_birth_body1.17461642
58MP0009115_abnormal_fat_cell1.17110537
59MP0000350_abnormal_cell_proliferation1.16172195
60MP0009780_abnormal_chondrocyte_physiolo1.15676913
61MP0003121_genomic_imprinting1.15562836
62MP0003656_abnormal_erythrocyte_physiolo1.14573121
63MP0008995_early_reproductive_senescence1.12821183
64MP0002166_altered_tumor_susceptibility1.11712043
65MP0003115_abnormal_respiratory_system1.08782204
66MP0008770_decreased_survivor_rate1.07997350
67MP0005621_abnormal_cell_physiology1.05833710
68MP0008007_abnormal_cellular_replicative1.04552626
69MP0005310_abnormal_salivary_gland1.03538779
70MP0003091_abnormal_cell_migration1.03501211
71MP0005257_abnormal_intraocular_pressure1.02305465
72MP0000537_abnormal_urethra_morphology1.02262929
73MP0004233_abnormal_muscle_weight1.02056650
74MP0001293_anophthalmia1.01683477
75MP0005666_abnormal_adipose_tissue1.01101720
76MP0001697_abnormal_embryo_size1.00644597
77* MP0000266_abnormal_heart_morphology0.99548895
78MP0010094_abnormal_chromosome_stability0.97752075
79MP0000432_abnormal_head_morphology0.97517340
80MP0005375_adipose_tissue_phenotype0.97126090
81MP0004185_abnormal_adipocyte_glucose0.95539219
82MP0002970_abnormal_white_adipose0.95141437
83MP0002697_abnormal_eye_size0.93173700
84MP0000313_abnormal_cell_death0.92599104
85MP0002114_abnormal_axial_skeleton0.92159128
86MP0003448_altered_tumor_morphology0.92122291
87MP0001730_embryonic_growth_arrest0.92091270
88MP0010678_abnormal_skin_adnexa0.89847002
89MP0000516_abnormal_urinary_system0.88577811
90MP0005367_renal/urinary_system_phenotyp0.88577811
91MP0002098_abnormal_vibrissa_morphology0.88403929
92MP0001784_abnormal_fluid_regulation0.88062320
93MP0002089_abnormal_postnatal_growth/wei0.87020761
94MP0009672_abnormal_birth_weight0.86513525
95MP0004947_skin_inflammation0.85555832
96MP0008877_abnormal_DNA_methylation0.84644838
97MP0000490_abnormal_crypts_of0.84330808
98* MP0002080_prenatal_lethality0.84281094
99MP0002653_abnormal_ependyma_morphology0.83454015
100MP0000371_diluted_coat_color0.83391973
101MP0001915_intracranial_hemorrhage0.82581003
102MP0002116_abnormal_craniofacial_bone0.82296687
103MP0003861_abnormal_nervous_system0.82186347
104MP0002092_abnormal_eye_morphology0.82021270
105MP0005023_abnormal_wound_healing0.81612434
106MP0004087_abnormal_muscle_fiber0.81321711
107* MP0002398_abnormal_bone_marrow0.81101271
108MP0003828_pulmonary_edema0.80143305
109MP0002006_tumorigenesis0.80068072
110MP0003453_abnormal_keratinocyte_physiol0.79318485
111MP0002928_abnormal_bile_duct0.78845662
112MP0003077_abnormal_cell_cycle0.78683353
113MP0001873_stomach_inflammation0.78046643
114MP0003567_abnormal_fetal_cardiomyocyte0.76677560
115MP0000003_abnormal_adipose_tissue0.76407001
116MP0005174_abnormal_tail_pigmentation0.75840017
117MP0001790_abnormal_immune_system0.75590188
118MP0005387_immune_system_phenotype0.75590188
119MP0002081_perinatal_lethality0.75363829
120MP0008932_abnormal_embryonic_tissue0.75002379
121MP0000751_myopathy0.73969207
122MP0005384_cellular_phenotype0.73544130
123MP0003763_abnormal_thymus_physiology0.73304700
124MP0001502_abnormal_circadian_rhythm0.72450884
125MP0003942_abnormal_urinary_system0.72053414
126MP0004957_abnormal_blastocyst_morpholog0.71175156
127MP0002722_abnormal_immune_system0.70652120
128MP0004130_abnormal_muscle_cell0.70643738
129MP0010155_abnormal_intestine_physiology0.70636450
130MP0003786_premature_aging0.70627745
131MP0002405_respiratory_system_inflammati0.70106407
132MP0000678_abnormal_parathyroid_gland0.69880848
133MP0000778_abnormal_nervous_system0.69352846
134MP0005451_abnormal_body_composition0.68849615
135MP0002108_abnormal_muscle_morphology0.66822621
136MP0003221_abnormal_cardiomyocyte_apopto0.65216806
137MP0001270_distended_abdomen0.65075341

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.13103214
2Septate vagina (HP:0001153)3.41617518
3Acute myeloid leukemia (HP:0004808)3.20904376
4Hyperacusis (HP:0010780)3.19436070
5Obstructive sleep apnea (HP:0002870)3.12907302
6Macroorchidism (HP:0000053)3.06002811
7Long eyelashes (HP:0000527)3.04109780
8Neonatal hypoglycemia (HP:0001998)3.00365697
9Urethral obstruction (HP:0000796)2.88582570
10Heterotopia (HP:0002282)2.80275460
11High anterior hairline (HP:0009890)2.80217952
12Rib fusion (HP:0000902)2.79689210
13Abnormality of the columella (HP:0009929)2.72108590
14Cerebral aneurysm (HP:0004944)2.67302335
15Supernumerary ribs (HP:0005815)2.65045300
16Sandal gap (HP:0001852)2.57097403
17Volvulus (HP:0002580)2.55096096
18Short 4th metacarpal (HP:0010044)2.53718467
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53718467
20Shallow orbits (HP:0000586)2.50310458
21Abnormality of the phalanges of the hallux (HP:0010057)2.48170993
22Abnormality of the astrocytes (HP:0100707)2.44540513
23Astrocytoma (HP:0009592)2.44540513
24Hypoplastic ischia (HP:0003175)2.40392626
25Elfin facies (HP:0004428)2.40021344
26Neoplasm of the oral cavity (HP:0100649)2.39279717
27Abnormality of chromosome segregation (HP:0002916)2.38341902
28Tapered finger (HP:0001182)2.37997104
29Ependymoma (HP:0002888)2.37614874
30Abnormality of the incisor (HP:0000676)2.35470215
31Chromsome breakage (HP:0040012)2.31483360
32Papillary thyroid carcinoma (HP:0002895)2.27861725
33Renovascular hypertension (HP:0100817)2.26180767
34Prominent nose (HP:0000448)2.25659842
35Abnormality of the aortic arch (HP:0012303)2.25266844
36Laryngomalacia (HP:0001601)2.23732464
37Skull defect (HP:0001362)2.22096097
38Narrow palate (HP:0000189)2.21088208
39Anal stenosis (HP:0002025)2.19743742
40Supernumerary bones of the axial skeleton (HP:0009144)2.19533423
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.18505881
42Cubitus valgus (HP:0002967)2.18037625
43Renal duplication (HP:0000075)2.17079322
44Deep palmar crease (HP:0006191)2.16833565
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15069751
46Submucous cleft hard palate (HP:0000176)2.13850239
47Increased nuchal translucency (HP:0010880)2.12964266
48Obsessive-compulsive behavior (HP:0000722)2.12928494
49Bowel incontinence (HP:0002607)2.11649635
50Long clavicles (HP:0000890)2.11189278
51Trigonocephaly (HP:0000243)2.11152007
52Hepatoblastoma (HP:0002884)2.10801840
53Intestinal fistula (HP:0100819)2.09763273
54Persistence of primary teeth (HP:0006335)2.08722575
55Broad face (HP:0000283)2.05950277
56Pseudobulbar signs (HP:0002200)2.03687792
57Germ cell neoplasia (HP:0100728)2.03295257
58Abnormal large intestine physiology (HP:0012700)2.00249601
59Protruding tongue (HP:0010808)1.99289700
60Abnormality of incisor morphology (HP:0011063)1.99088560
61Abnormality of the radial head (HP:0003995)1.98878497
62Truncal obesity (HP:0001956)1.96076936
63Abnormality of the ischium (HP:0003174)1.95613730
64Abnormal hair whorl (HP:0010721)1.95189200
65Broad thumb (HP:0011304)1.94871245
66Abnormality of the nasal septum (HP:0000419)1.93024242
67Skin tags (HP:0010609)1.92523810
68Depressed nasal tip (HP:0000437)1.91441483
69Abnormality of the 4th metacarpal (HP:0010012)1.91371095
70Absent frontal sinuses (HP:0002688)1.91336073
71Sparse lateral eyebrow (HP:0005338)1.90560555
72Deviation of the thumb (HP:0009603)1.90385623
73Uterine leiomyosarcoma (HP:0002891)1.89447048
74Leiomyosarcoma (HP:0100243)1.89447048
75Acute lymphatic leukemia (HP:0006721)1.89359196
76Broad palm (HP:0001169)1.89225971
77Limited elbow extension (HP:0001377)1.86708875
78Insomnia (HP:0100785)1.86340914
79Ureteral obstruction (HP:0006000)1.85832473
80Glioma (HP:0009733)1.85641183
81Large earlobe (HP:0009748)1.84851503
82Smooth philtrum (HP:0000319)1.83668065
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83213914
84Gastrointestinal carcinoma (HP:0002672)1.82115456
85Malignant gastrointestinal tract tumors (HP:0006749)1.82115456
86Proximal placement of thumb (HP:0009623)1.82010455
87Deep philtrum (HP:0002002)1.81747251
88Lower limb amyotrophy (HP:0007210)1.81475962
89Ureteral stenosis (HP:0000071)1.80879442
90Underdeveloped nasal alae (HP:0000430)1.80105599
91Pointed chin (HP:0000307)1.79817353
92Transitional cell carcinoma of the bladder (HP:0006740)1.79032514
93Aneurysm (HP:0002617)1.77001794
942-3 toe syndactyly (HP:0004691)1.76151846
95Thick eyebrow (HP:0000574)1.76116342
96Sparse scalp hair (HP:0002209)1.76109751
97Hypoplasia of the maxilla (HP:0000327)1.75825884
98Low anterior hairline (HP:0000294)1.75799398
99Cafe-au-lait spot (HP:0000957)1.75500669
100Vertebral fusion (HP:0002948)1.75410340
101Synophrys (HP:0000664)1.75275646
102Relative macrocephaly (HP:0004482)1.75264605
103Vertebral arch anomaly (HP:0008438)1.74706009
104Flat cornea (HP:0007720)1.74667999
105Overriding aorta (HP:0002623)1.74221018
106Spina bifida occulta (HP:0003298)1.72984818
107Abnormality of the lower motor neuron (HP:0002366)1.72280410
108Increased density of long bones (HP:0006392)1.71316304
109Lip pit (HP:0100267)1.70616620
110Abnormality of the thoracic spine (HP:0100711)1.70593272
111Overgrowth (HP:0001548)1.70149360
112Cutis marmorata (HP:0000965)1.69865923
113Abnormal number of incisors (HP:0011064)1.68844689
114Midline defect of the nose (HP:0004122)1.68755441
115Short phalanx of the thumb (HP:0009660)1.68385496
116Ulnar bowing (HP:0003031)1.68128099
117Genetic anticipation (HP:0003743)1.68037770
118Neoplasm of the heart (HP:0100544)1.68013126
119Tented upper lip vermilion (HP:0010804)1.68007553
120Deeply set eye (HP:0000490)1.67596126
121Intestinal malrotation (HP:0002566)1.67429886
122Short middle phalanx of finger (HP:0005819)1.67328377
123Radioulnar synostosis (HP:0002974)1.66664543
124Bowel diverticulosis (HP:0005222)1.66150272
125Disproportionate tall stature (HP:0001519)1.65862683
126Bladder carcinoma (HP:0002862)1.65414054
127Bladder neoplasm (HP:0009725)1.65414054
128Hyperventilation (HP:0002883)1.65125216
129Attention deficit hyperactivity disorder (HP:0007018)1.64790700
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.64755671
131Dysmetric saccades (HP:0000641)1.64650659
132Truncus arteriosus (HP:0001660)1.64619412
133Low posterior hairline (HP:0002162)1.64543459
134Distal lower limb amyotrophy (HP:0008944)1.64011319
135Mask-like facies (HP:0000298)1.62083757
136Mitral valve prolapse (HP:0001634)1.61775334
137Open mouth (HP:0000194)1.61293924
138Abnormality of the diencephalon (HP:0010662)1.60387876
139Ankyloglossia (HP:0010296)1.60171732
140Abnormality of the 1st metacarpal (HP:0010009)1.60041365
141Sporadic (HP:0003745)1.56739711
142Rectal prolapse (HP:0002035)1.56518951
143Dislocated radial head (HP:0003083)1.54962949
144Ectopic kidney (HP:0000086)1.54792134
145Distal upper limb amyotrophy (HP:0007149)1.54452460
146Upper limb amyotrophy (HP:0009129)1.54452460
147Autoimmune thrombocytopenia (HP:0001973)1.54133315
148Preauricular skin tag (HP:0000384)1.54089225
149Neoplasm of striated muscle (HP:0009728)1.53372560
150Oligodontia (HP:0000677)1.53179006
151Abnormality of the labia minora (HP:0012880)1.52844112
152Hand muscle atrophy (HP:0009130)1.52264459
153Broad phalanges of the hand (HP:0009768)1.51757419
154Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.51742268
155Short 1st metacarpal (HP:0010034)1.51742268
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.51569165
157Basal cell carcinoma (HP:0002671)1.51158586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.73593544
2MAP3K103.06765151
3BRD43.04616402
4PRPF4B3.04408197
5ICK2.85252529
6CAMK1G2.63794694
7CAMK1D2.46750996
8SIK22.22413277
9TRIB32.19032460
10EEF2K2.17729352
11RIPK11.90219217
12EPHA21.86909104
13SMG11.79012465
14MTOR1.71333109
15ALK1.64884942
16PKN21.64680950
17SIK11.62219817
18PTK61.52918502
19MAP4K11.51785128
20AKT31.43971792
21PDGFRA1.43416714
22LATS11.42692433
23ERN11.37222280
24TYRO31.36350103
25DMPK1.35746195
26KSR21.23964220
27TTN1.23302849
28BMX1.21183992
29CDK61.19274476
30RIPK41.17316501
31STK31.15680387
32PRKD31.15259529
33TAOK11.13082403
34CDK41.08571605
35MAP3K71.08080904
36CHUK1.06228901
37MAP3K21.04681310
38PRKD21.00499473
39SGK30.99075062
40STK100.99031668
41MARK20.97759724
42FGFR30.95860927
43MAP3K140.94874172
44NEK20.94275150
45PDGFRB0.94145633
46CDC42BPA0.93497603
47MELK0.93324563
48CDK30.91026357
49EPHB10.90496461
50CDK70.89189869
51NTRK30.85262883
52HIPK20.85166852
53SGK2230.85035307
54SGK4940.85035307
55PRKCH0.84978232
56CDC70.82994338
57CSK0.82753368
58NLK0.81637212
59MAP2K30.79364213
60HCK0.77758374
61TAOK30.77570875
62MAPK110.77356251
63CDK90.76997648
64IRAK10.74705520
65IRAK30.74157767
66KSR10.73139792
67CAMK40.72233444
68STK40.71571674
69IRAK20.71042219
70TAOK20.70165832
71STK380.69999271
72ATM0.69973814
73MAP3K130.68845369
74* CHEK10.67274163
75ATR0.65880157
76PAK40.64118871
77RAF10.63943129
78WNK10.63412522
79CDK20.63076995
80STK110.62377511
81DDR20.62327365
82FGFR20.61737060
83CSNK1D0.61656536
84MKNK20.61647585
85JAK10.61141616
86MAP3K60.60811330
87GRK60.60803883
88SIK30.59978812
89MARK30.59170172
90PIM10.56945198
91PTK20.56745592
92TYK20.55855181
93MAPK80.55656880
94DYRK1B0.55142632
95MAPK10.55055519
96* MAPK140.54975655
97RET0.53833882
98PRKDC0.53747540
99* GSK3B0.53515597
100PAK20.53488217
101RPS6KA10.53073889
102TTK0.52377501
103CSF1R0.50851182
104MAPK100.50747706
105JAK20.49478663
106BTK0.48660779
107CLK10.48216960
108TNK20.48057372
109AKT10.47948882
110FGFR10.46996778
111SGK20.46840166
112TRPM70.46608195
113ERBB20.45421437
114FGFR40.44837603
115NTRK20.44640335
116PDPK10.44294078
117CHEK20.44070063
118IRAK40.44056484
119PDK10.43569505
120FRK0.43406092
121MAPK150.43201260
122PRKAA10.42702435
123RPS6KA60.42258253
124MAP3K90.41737711
125MKNK10.40811271
126RPS6KA20.40453749
127SGK10.40295507
128PNCK0.39475181
129* CDK10.38582885
130MATK0.37970567
131EGFR0.37476517
132GSK3A0.37246502
133PRKAA20.36744161
134MAPK70.36711674
135RPS6KC10.36135427
136RPS6KL10.36135427
137RPS6KB20.35963453

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.32909143
2Notch signaling pathway_Homo sapiens_hsa043301.96993581
3mTOR signaling pathway_Homo sapiens_hsa041501.70716777
4Dorso-ventral axis formation_Homo sapiens_hsa043201.68987823
5Chronic myeloid leukemia_Homo sapiens_hsa052201.62609874
6Acute myeloid leukemia_Homo sapiens_hsa052211.49694740
7Non-homologous end-joining_Homo sapiens_hsa034501.44528904
8Type II diabetes mellitus_Homo sapiens_hsa049301.44038609
9MicroRNAs in cancer_Homo sapiens_hsa052061.41968003
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.41607251
11B cell receptor signaling pathway_Homo sapiens_hsa046621.40026079
12Adherens junction_Homo sapiens_hsa045201.38907647
13Cell cycle_Homo sapiens_hsa041101.35861336
14Basal cell carcinoma_Homo sapiens_hsa052171.26790350
15Endometrial cancer_Homo sapiens_hsa052131.24583815
16mRNA surveillance pathway_Homo sapiens_hsa030151.23240201
17Osteoclast differentiation_Homo sapiens_hsa043801.17801456
18Small cell lung cancer_Homo sapiens_hsa052221.17524753
19Non-small cell lung cancer_Homo sapiens_hsa052231.16460608
20Proteoglycans in cancer_Homo sapiens_hsa052051.15455355
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13971507
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13400340
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13237974
24Viral myocarditis_Homo sapiens_hsa054161.12962622
25Glioma_Homo sapiens_hsa052141.11136101
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11047199
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09423884
28T cell receptor signaling pathway_Homo sapiens_hsa046601.08855606
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08523608
30Insulin resistance_Homo sapiens_hsa049311.06779599
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.06513672
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02845102
33Prolactin signaling pathway_Homo sapiens_hsa049171.02126369
34Thyroid cancer_Homo sapiens_hsa052161.01865399
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01697910
36Colorectal cancer_Homo sapiens_hsa052101.00807137
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99930705
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99122218
39HTLV-I infection_Homo sapiens_hsa051660.98272120
40Focal adhesion_Homo sapiens_hsa045100.95917182
41Pancreatic cancer_Homo sapiens_hsa052120.95446051
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95331843
43ErbB signaling pathway_Homo sapiens_hsa040120.95141619
44Estrogen signaling pathway_Homo sapiens_hsa049150.94647673
45Wnt signaling pathway_Homo sapiens_hsa043100.94010164
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.93863400
47VEGF signaling pathway_Homo sapiens_hsa043700.93087242
48Prostate cancer_Homo sapiens_hsa052150.90495106
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90049432
50Hippo signaling pathway_Homo sapiens_hsa043900.89865656
51Leishmaniasis_Homo sapiens_hsa051400.89726350
52Dilated cardiomyopathy_Homo sapiens_hsa054140.89029094
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.87800789
54Circadian rhythm_Homo sapiens_hsa047100.87758268
55Renal cell carcinoma_Homo sapiens_hsa052110.86608586
56MAPK signaling pathway_Homo sapiens_hsa040100.85017535
57Choline metabolism in cancer_Homo sapiens_hsa052310.84915416
58Toxoplasmosis_Homo sapiens_hsa051450.84467339
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84186016
60FoxO signaling pathway_Homo sapiens_hsa040680.82995997
61Hepatitis C_Homo sapiens_hsa051600.82904443
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82863504
63Spliceosome_Homo sapiens_hsa030400.82842642
64Hedgehog signaling pathway_Homo sapiens_hsa043400.81889686
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81853441
66Hepatitis B_Homo sapiens_hsa051610.81475926
67AMPK signaling pathway_Homo sapiens_hsa041520.80420849
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79734086
69Measles_Homo sapiens_hsa051620.79679312
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.79290953
71Primary immunodeficiency_Homo sapiens_hsa053400.78684045
72Pathways in cancer_Homo sapiens_hsa052000.78494758
73Rap1 signaling pathway_Homo sapiens_hsa040150.78227101
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.77182240
75Herpes simplex infection_Homo sapiens_hsa051680.76599439
76Chemokine signaling pathway_Homo sapiens_hsa040620.76167157
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76043692
78Insulin signaling pathway_Homo sapiens_hsa049100.75842418
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74690080
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.74244838
81DNA replication_Homo sapiens_hsa030300.73651131
82Bladder cancer_Homo sapiens_hsa052190.73582876
83Inositol phosphate metabolism_Homo sapiens_hsa005620.73266802
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72029681
85TNF signaling pathway_Homo sapiens_hsa046680.71420775
86Influenza A_Homo sapiens_hsa051640.71140788
87HIF-1 signaling pathway_Homo sapiens_hsa040660.68719431
88Amoebiasis_Homo sapiens_hsa051460.68665768
89Cholinergic synapse_Homo sapiens_hsa047250.68293469
90Viral carcinogenesis_Homo sapiens_hsa052030.67070521
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67035720
92Platelet activation_Homo sapiens_hsa046110.66999484
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.66960956
94Long-term depression_Homo sapiens_hsa047300.66875178
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66684845
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65914775
97TGF-beta signaling pathway_Homo sapiens_hsa043500.65330462
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65317752
99Epstein-Barr virus infection_Homo sapiens_hsa051690.64886047
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64417017
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.64379122
102Melanogenesis_Homo sapiens_hsa049160.64038615
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63134038
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62308784
105Glucagon signaling pathway_Homo sapiens_hsa049220.62146030
106RNA transport_Homo sapiens_hsa030130.61590958
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61345394
108GnRH signaling pathway_Homo sapiens_hsa049120.61210342
109Axon guidance_Homo sapiens_hsa043600.60443626
110Insulin secretion_Homo sapiens_hsa049110.60006471
111Apoptosis_Homo sapiens_hsa042100.59961816
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59377172
113ECM-receptor interaction_Homo sapiens_hsa045120.59108220
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58545150
115cAMP signaling pathway_Homo sapiens_hsa040240.57956510
116Melanoma_Homo sapiens_hsa052180.57200986
117Long-term potentiation_Homo sapiens_hsa047200.56979762
118Fanconi anemia pathway_Homo sapiens_hsa034600.55465860
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52550398
120Prion diseases_Homo sapiens_hsa050200.50388270
121Oocyte meiosis_Homo sapiens_hsa041140.48033467

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