SPESP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.94702606
2cell-cell recognition (GO:0009988)9.72217960
3epithelial cilium movement (GO:0003351)9.57331907
4spermatid development (GO:0007286)9.16183095
5motile cilium assembly (GO:0044458)9.06500533
6* acrosome reaction (GO:0007340)8.84886048
7male meiosis (GO:0007140)8.80730236
8reproduction (GO:0000003)8.61178209
9synaptonemal complex organization (GO:0070193)8.53728978
10* plasma membrane fusion (GO:0045026)8.35706476
11synaptonemal complex assembly (GO:0007130)8.31450077
12cilium movement (GO:0003341)8.14221264
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.97450001
14regulation of cilium movement (GO:0003352)7.76552109
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.06671752
16single fertilization (GO:0007338)7.03135407
17sperm capacitation (GO:0048240)6.49991636
18DNA methylation involved in gamete generation (GO:0043046)6.41490258
19male meiosis I (GO:0007141)6.33279646
20fertilization (GO:0009566)6.20440931
21negative regulation of inclusion body assembly (GO:0090084)6.11960505
22spermatogenesis (GO:0007283)6.11100209
23male gamete generation (GO:0048232)6.09126960
24regulation of retinoic acid receptor signaling pathway (GO:0048385)5.99938021
25melanin biosynthetic process (GO:0042438)5.98469744
26microtubule depolymerization (GO:0007019)5.91462755
27chromosome organization involved in meiosis (GO:0070192)5.84272893
28gamete generation (GO:0007276)5.61556764
29meiotic nuclear division (GO:0007126)5.43565162
30positive regulation of meiosis (GO:0045836)5.37630244
31germ cell development (GO:0007281)5.33972183
32organic cation transport (GO:0015695)5.25515500
33meiosis I (GO:0007127)5.24626897
34* cellular process involved in reproduction in multicellular organism (GO:0022412)5.23737411
35melanin metabolic process (GO:0006582)5.23040681
36ventricular system development (GO:0021591)5.21247113
37regulation of inclusion body assembly (GO:0090083)5.11922259
38positive regulation of meiotic cell cycle (GO:0051446)5.09313510
39seminiferous tubule development (GO:0072520)5.04631443
40rRNA modification (GO:0000154)4.86763749
41rRNA methylation (GO:0031167)4.85362601
42secondary metabolite biosynthetic process (GO:0044550)4.74753193
43microtubule severing (GO:0051013)4.71272929
44cell recognition (GO:0008037)4.62284856
45regulation of microtubule-based movement (GO:0060632)4.56458091
46monoubiquitinated protein deubiquitination (GO:0035520)4.54972140
47meiotic cell cycle (GO:0051321)4.54762187
48gonadal mesoderm development (GO:0007506)4.52889857
49multicellular organismal reproductive process (GO:0048609)4.40663334
50oogenesis (GO:0048477)4.21139701
51proteasome assembly (GO:0043248)4.18379086
52left/right pattern formation (GO:0060972)4.17983235
53protein localization to cilium (GO:0061512)4.03410665
54chromosome condensation (GO:0030261)4.00939401
55female gamete generation (GO:0007292)3.97112867
56resolution of meiotic recombination intermediates (GO:0000712)3.95378358
57genitalia morphogenesis (GO:0035112)3.93608453
58DNA packaging (GO:0006323)3.92116267
59negative regulation of meiosis (GO:0045835)3.91919814
60spermatid nucleus differentiation (GO:0007289)3.87283063
61meiotic chromosome segregation (GO:0045132)3.86558338
62chaperone-mediated protein complex assembly (GO:0051131)3.83223691
63gene silencing by RNA (GO:0031047)3.80277979
64* calcium ion-dependent exocytosis (GO:0017156)3.78221542
65regulation of meiosis (GO:0040020)3.75009742
66meiotic cell cycle process (GO:1903046)3.73613060
67regulation of meiotic cell cycle (GO:0051445)3.68206013
68amino-acid betaine transport (GO:0015838)3.62719842
69carnitine transport (GO:0015879)3.62719842
70mitotic chromosome condensation (GO:0007076)3.61488591
71carnitine transmembrane transport (GO:1902603)3.61463011
72protein K6-linked ubiquitination (GO:0085020)3.55741189
73protein polyglutamylation (GO:0018095)3.51764845
74glycerol ether metabolic process (GO:0006662)3.47819543
75nuclear pore complex assembly (GO:0051292)3.47218983
76* multicellular organismal development (GO:0007275)3.45336006
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45052407
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45052407
79positive regulation of mitotic sister chromatid separation (GO:1901970)3.45052407
80mitotic metaphase plate congression (GO:0007080)3.44226793
81cellular copper ion homeostasis (GO:0006878)3.44068087
82regulation of spindle checkpoint (GO:0090231)3.43054337
83synapsis (GO:0007129)3.42268779
84intraciliary transport (GO:0042073)3.40540302
85ketone body metabolic process (GO:1902224)3.39307161
86regulation of meiosis I (GO:0060631)3.34621664
87inositol phosphate dephosphorylation (GO:0046855)3.31910015
88phosphorylated carbohydrate dephosphorylation (GO:0046838)3.31910015
89regulation of centriole replication (GO:0046599)3.30054994
90axoneme assembly (GO:0035082)3.29943694
91DNA synthesis involved in DNA repair (GO:0000731)3.29596016
92negative regulation of organelle assembly (GO:1902116)3.27097343
93mitotic sister chromatid cohesion (GO:0007064)3.27015966
94protein targeting to Golgi (GO:0000042)3.26693537
95protein K11-linked deubiquitination (GO:0035871)3.20719702
96ether metabolic process (GO:0018904)3.20573260
97attachment of spindle microtubules to kinetochore (GO:0008608)3.17920085
98microtubule-based movement (GO:0007018)3.14768480
99microtubule polymerization or depolymerization (GO:0031109)3.10224884
100nucleus organization (GO:0006997)3.07732355
101regulation of DNA endoreduplication (GO:0032875)3.05528971
102establishment of protein localization to Golgi (GO:0072600)3.05003667
103inositol phosphate catabolic process (GO:0071545)3.04343628
104regulation of early endosome to late endosome transport (GO:2000641)3.02556596
105protein refolding (GO:0042026)3.01832458
106sequestering of actin monomers (GO:0042989)3.00073499
107single strand break repair (GO:0000012)3.00057432
108polyol catabolic process (GO:0046174)2.96743474
109positive regulation of chromosome segregation (GO:0051984)2.96069827
110cilium organization (GO:0044782)2.93552306
111reciprocal meiotic recombination (GO:0007131)2.92981191
112reciprocal DNA recombination (GO:0035825)2.92981191
113alditol metabolic process (GO:0019400)2.88468295
114nuclear pore organization (GO:0006999)2.87393307
115metaphase plate congression (GO:0051310)2.84572766
116gene silencing (GO:0016458)2.84289332
117negative regulation of meiotic cell cycle (GO:0051447)2.83944716
118centriole replication (GO:0007099)2.82834981
119nucleoside diphosphate phosphorylation (GO:0006165)2.82627419
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.82538023
121histone exchange (GO:0043486)2.79886464
122centriole assembly (GO:0098534)2.78919781
123copper ion homeostasis (GO:0055070)2.78890174
124lactate metabolic process (GO:0006089)2.78668195
125cilium assembly (GO:0042384)2.76863718
126cilium morphogenesis (GO:0060271)2.76727199
127sister chromatid cohesion (GO:0007062)2.76387320
128regulation of oxidative phosphorylation (GO:0002082)2.75856103
129interferon-gamma secretion (GO:0072643)2.73103061
130protein localization to chromosome, centromeric region (GO:0071459)2.72461535
131cellular component assembly involved in morphogenesis (GO:0010927)2.71535362
132regulation of protein polyubiquitination (GO:1902914)2.70314516
133pore complex assembly (GO:0046931)2.68543384
134cellular response to zinc ion (GO:0071294)2.67855335
135oocyte development (GO:0048599)2.66923105
136response to pheromone (GO:0019236)2.64051992
137regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61109377
138tyrosine metabolic process (GO:0006570)2.57252364
139mitochondrial fission (GO:0000266)2.56152811
140nucleotide transmembrane transport (GO:1901679)2.54419214
141phenol-containing compound biosynthetic process (GO:0046189)2.52231598
142cellular ketone body metabolic process (GO:0046950)2.50249482
143histone H3-K9 demethylation (GO:0033169)2.48500009
144cilium or flagellum-dependent cell motility (GO:0001539)12.8529257
145sperm motility (GO:0030317)11.9914322
146* fusion of sperm to egg plasma membrane (GO:0007342)11.3303160
147acrosome assembly (GO:0001675)10.9650791
148sperm-egg recognition (GO:0035036)10.8785650
149cell wall macromolecule catabolic process (GO:0016998)10.5465231
150cell wall macromolecule metabolic process (GO:0044036)10.5465231
151multicellular organism reproduction (GO:0032504)10.4059907
152axonemal dynein complex assembly (GO:0070286)10.2464966
153binding of sperm to zona pellucida (GO:0007339)10.0698362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66013105
2EZH2_22144423_ChIP-Seq_EOC_Human4.45819677
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12900704
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.66713613
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54994131
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.79426750
7* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.55731248
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52046616
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45890918
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41301900
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29781388
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.26446808
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26367061
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23974242
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.16559817
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.12023442
17TFEB_21752829_ChIP-Seq_HELA_Human2.09268204
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.01505904
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01091429
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00299584
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7518645
22IGF1R_20145208_ChIP-Seq_DFB_Human1.98917660
23ZNF274_21170338_ChIP-Seq_K562_Hela1.98628597
24ELK1_19687146_ChIP-ChIP_HELA_Human1.98568673
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97560040
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96834665
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.96791615
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96133031
29DCP1A_22483619_ChIP-Seq_HELA_Human1.94758177
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93258909
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89147883
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82536839
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73345486
34VDR_22108803_ChIP-Seq_LS180_Human1.70752360
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.70637562
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67932205
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66033760
38FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65410279
39STAT1_17558387_ChIP-Seq_HELA_Human1.63767683
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62621400
41AR_21909140_ChIP-Seq_LNCAP_Human1.61338728
42GABP_19822575_ChIP-Seq_HepG2_Human1.59930710
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59073179
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56473653
45VDR_23849224_ChIP-Seq_CD4+_Human1.55977873
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53440148
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.52451224
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50938124
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49477334
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46957252
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45394080
52SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42930749
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42691218
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42641619
55GATA3_21867929_ChIP-Seq_CD8_Mouse1.41778506
56ER_23166858_ChIP-Seq_MCF-7_Human1.36640097
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.35903654
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34413062
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32676603
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.32137530
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31126808
62RBPJ_21746931_ChIP-Seq_IB4_Human1.30382761
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29942120
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29153648
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.28259548
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27916963
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26846161
68CBP_20019798_ChIP-Seq_JUKART_Human1.26846161
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26449776
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24921803
71FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24908858
72FOXP3_21729870_ChIP-Seq_TREG_Human1.24140661
73SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23838941
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22369349
75KDM2B_26808549_Chip-Seq_REH_Human1.22278353
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21872615
77* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21732262
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21630183
79TTF2_22483619_ChIP-Seq_HELA_Human1.21604149
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21572991
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21444222
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20853802
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19207561
84P53_21459846_ChIP-Seq_SAOS-2_Human1.18794090
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18522484
86ETV1_20927104_ChIP-Seq_GIST48_Human1.17662541
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17643771
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17491751
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.17447747
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.17087142
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15171562
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15077223
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.14407769
94RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13751298
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13747933
96FUS_26573619_Chip-Seq_HEK293_Human1.13526421
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13079502
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12905025
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.11016132
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10468519
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09383056
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.07518201
103PHF8_20622853_ChIP-Seq_HELA_Human1.06929467
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05930443
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05930443
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05213226
107HTT_18923047_ChIP-ChIP_STHdh_Human1.04428880
108REST_21632747_ChIP-Seq_MESCs_Mouse1.04039600
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03640423
110* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03477786
111GF1_26923725_Chip-Seq_HPCs_Mouse1.03395561
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.03034997
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02303008
114* FOXA1_25329375_ChIP-Seq_VCAP_Human1.02074931
115* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02074931
116AR_25329375_ChIP-Seq_VCAP_Human1.01547445
117MYC_18940864_ChIP-ChIP_HL60_Human1.00606469
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99674062
119NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99549575
120* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99217492
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98993822
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.98394441
123MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98356774
124SPI1_26923725_Chip-Seq_HPCs_Mouse0.97548007
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.97040425
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96990755
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96878322
128LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96620774
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96613678
130GATA3_26560356_Chip-Seq_TH1_Human0.96509158
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.96469500
132TP63_23658742_ChIP-Seq_EP156T_Human0.96329582
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96054660
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95901918
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.95862497
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95556231
137BRD4_25478319_ChIP-Seq_HGPS_Human0.95199786
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95123239
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.94962652
140TP53_22573176_ChIP-Seq_HFKS_Human0.94943229
141HOXB7_26014856_ChIP-Seq_BT474_Human0.94870391
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94728644
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.94582047
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.94451148
145BCAT_22108803_ChIP-Seq_LS180_Human0.93485282
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93314469
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93121804
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93015953
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92785630
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.92551502
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91299086
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91248909
153P53_22387025_ChIP-Seq_ESCs_Mouse0.91157631
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90942730
155RNF2_27304074_Chip-Seq_NSC_Mouse0.90817605
156HNFA_21074721_ChIP-Seq_CACO-2_Human0.90796721
157* FLI1_21867929_ChIP-Seq_CD8_Mouse0.90697898
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89810643
159SOX2_21211035_ChIP-Seq_LN229_Human0.89521164
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89462814
161TP53_18474530_ChIP-ChIP_U2OS_Human0.89426528
162* ERG_20517297_ChIP-Seq_VCAP_Human0.89093943
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.88548382
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88503252
165TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88275932
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88233945
167RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88116575
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87528877
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87063109
170* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86692539
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85339234
172EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84301291
173P300_18555785_Chip-Seq_ESCs_Mouse0.84259648
174MYC_27129775_Chip-Seq_CORNEA_Mouse0.83525163
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83180140
176ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83108946
177ELF1_20517297_ChIP-Seq_JURKAT_Human0.82530935
178NFYB_21822215_ChIP-Seq_K562_Human0.82370522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.54963488
2* MP0003698_abnormal_male_reproductive5.95462303
3* MP0001929_abnormal_gametogenesis5.61483782
4MP0008877_abnormal_DNA_methylation5.53777301
5MP0005171_absent_coat_pigmentation4.50404851
6MP0002210_abnormal_sex_determination3.96786130
7MP0003806_abnormal_nucleotide_metabolis3.68857007
8MP0005408_hypopigmentation3.63196754
9MP0001145_abnormal_male_reproductive3.36672908
10MP0002161_abnormal_fertility/fecundity3.30869392
11MP0002653_abnormal_ependyma_morphology3.17427553
12MP0000653_abnormal_sex_gland2.94017569
13MP0010368_abnormal_lymphatic_system2.72802136
14MP0000015_abnormal_ear_pigmentation2.67991448
15MP0009697_abnormal_copulation2.55726610
16MP0002877_abnormal_melanocyte_morpholog2.28266022
17MP0002160_abnormal_reproductive_system2.26132096
18MP0003136_yellow_coat_color2.24412928
19MP0003718_maternal_effect2.24251937
20MP0003186_abnormal_redox_activity2.17869847
21MP0008057_abnormal_DNA_replication2.15067093
22MP0002095_abnormal_skin_pigmentation2.09581282
23MP0008438_abnormal_cutaneous_collagen2.08210225
24MP0005075_abnormal_melanosome_morpholog2.06193372
25MP0005670_abnormal_white_adipose2.05075320
26* MP0005410_abnormal_fertilization14.6601320
27MP0005174_abnormal_tail_pigmentation1.87906478
28MP0005623_abnormal_meninges_morphology1.84182703
29MP0000371_diluted_coat_color1.77255252
30MP0003646_muscle_fatigue1.71060052
31MP0008260_abnormal_autophagy1.71028057
32MP0010094_abnormal_chromosome_stability1.69383672
33MP0008058_abnormal_DNA_repair1.66746391
34MP0005058_abnormal_lysosome_morphology1.64261630
35MP0009780_abnormal_chondrocyte_physiolo1.57431123
36MP0003283_abnormal_digestive_organ1.57253308
37MP0005275_abnormal_skin_tensile1.53312075
38MP0010234_abnormal_vibrissa_follicle1.52049269
39MP0005257_abnormal_intraocular_pressure1.44960710
40MP0004381_abnormal_hair_follicle1.43981537
41MP0002060_abnormal_skin_morphology1.38834867
42MP0003941_abnormal_skin_development1.28226077
43MP0000013_abnormal_adipose_tissue1.27765234
44MP0003111_abnormal_nucleus_morphology1.26912934
45MP0004233_abnormal_muscle_weight1.26869442
46MP0002638_abnormal_pupillary_reflex1.22366850
47MP0008995_early_reproductive_senescence1.21965918
48MP0002295_abnormal_pulmonary_circulatio1.20766994
49MP0008007_abnormal_cellular_replicative1.20064989
50MP0000678_abnormal_parathyroid_gland1.19740874
51MP0010386_abnormal_urinary_bladder1.19633039
52MP0005389_reproductive_system_phenotype1.16207151
53MP0005503_abnormal_tendon_morphology1.15139336
54MP0002282_abnormal_trachea_morphology1.14965978
55MP0005647_abnormal_sex_gland1.14827678
56MP0005379_endocrine/exocrine_gland_phen1.10563916
57MP0003786_premature_aging1.04052763
58MP0001879_abnormal_lymphatic_vessel1.02709199
59MP0002075_abnormal_coat/hair_pigmentati1.00919054
60MP0005409_darkened_coat_color1.00912108
61MP0005395_other_phenotype1.00700208
62MP0002938_white_spotting0.97780830
63MP0009046_muscle_twitch0.94531979
64MP0010678_abnormal_skin_adnexa0.91541954
65MP0001186_pigmentation_phenotype0.90764659
66MP0003077_abnormal_cell_cycle0.90323061
67MP0001984_abnormal_olfaction0.86812223
68MP0001765_abnormal_ion_homeostasis0.85448154
69MP0000427_abnormal_hair_cycle0.83594337
70MP0003183_abnormal_peptide_metabolism0.81436169
71MP0001730_embryonic_growth_arrest0.79931030
72MP0000462_abnormal_digestive_system0.79366610
73MP0010307_abnormal_tumor_latency0.79090654
74MP0003693_abnormal_embryo_hatching0.78225209
75MP0003878_abnormal_ear_physiology0.77095771
76MP0005377_hearing/vestibular/ear_phenot0.77095771
77MP0000383_abnormal_hair_follicle0.76513881
78MP0003011_delayed_dark_adaptation0.74038080
79MP0000358_abnormal_cell_content/0.72898449
80MP0005330_cardiomyopathy0.72774259
81MP0004215_abnormal_myocardial_fiber0.70892970
82MP0004782_abnormal_surfactant_physiolog0.69253372
83MP0001944_abnormal_pancreas_morphology0.67928897
84MP0003115_abnormal_respiratory_system0.67788959
85MP0003699_abnormal_female_reproductive0.65945528
86MP0003950_abnormal_plasma_membrane0.65342693
87MP0002837_dystrophic_cardiac_calcinosis0.61840543
88MP0005397_hematopoietic_system_phenotyp0.61060968
89MP0001545_abnormal_hematopoietic_system0.61060968
90MP0003123_paternal_imprinting0.60236670
91MP0001119_abnormal_female_reproductive0.57950289
92MP0000569_abnormal_digit_pigmentation0.57408534
93MP0002177_abnormal_outer_ear0.56275182
94MP0004957_abnormal_blastocyst_morpholog0.55729181
95MP0005666_abnormal_adipose_tissue0.54794102
96MP0004808_abnormal_hematopoietic_stem0.54647196
97MP0002090_abnormal_vision0.52178553
98MP0001293_anophthalmia0.51887734
99MP0002163_abnormal_gland_morphology0.51259827
100MP0002108_abnormal_muscle_morphology0.50999573
101MP0002102_abnormal_ear_morphology0.50769445
102MP0002084_abnormal_developmental_patter0.50289197
103MP0002234_abnormal_pharynx_morphology0.50116575
104MP0003943_abnormal_hepatobiliary_system0.49344623
105MP0001672_abnormal_embryogenesis/_devel0.49142652
106MP0005380_embryogenesis_phenotype0.49142652
107MP0010771_integument_phenotype0.49111954
108MP0001661_extended_life_span0.48853074
109MP0005197_abnormal_uvea_morphology0.48422004
110MP0002332_abnormal_exercise_endurance0.48357286
111MP0000003_abnormal_adipose_tissue0.48011160
112MP0003453_abnormal_keratinocyte_physiol0.46106175
113MP0001697_abnormal_embryo_size0.45192069
114MP0009278_abnormal_bone_marrow0.45183506
115MP0000313_abnormal_cell_death0.43239150
116MP0004134_abnormal_chest_morphology0.42484717
117MP0005636_abnormal_mineral_homeostasis0.41659449
118MP0002269_muscular_atrophy0.41530686
119MP0004019_abnormal_vitamin_homeostasis0.39988420
120MP0006036_abnormal_mitochondrial_physio0.39539950
121MP0003984_embryonic_growth_retardation0.38985459
122MP0001727_abnormal_embryo_implantation0.38397738
123MP0003861_abnormal_nervous_system0.37838531
124MP0002928_abnormal_bile_duct0.37359914
125MP0002085_abnormal_embryonic_tissue0.36968575
126MP0008932_abnormal_embryonic_tissue0.36870223
127MP0002088_abnormal_embryonic_growth/wei0.36168289
128MP0002080_prenatal_lethality0.35847179
129MP0005391_vision/eye_phenotype0.33437236
130MP0004036_abnormal_muscle_relaxation0.33426145
131MP0001324_abnormal_eye_pigmentation0.33392592
132MP0001764_abnormal_homeostasis0.31779497
133MP0001849_ear_inflammation0.31698407
134MP0002971_abnormal_brown_adipose0.30753314
135MP0009115_abnormal_fat_cell0.30675780
136MP0005253_abnormal_eye_physiology0.30174906
137MP0002092_abnormal_eye_morphology0.29845884
138MP0000350_abnormal_cell_proliferation0.29363029
139MP0003936_abnormal_reproductive_system0.29355324
140MP0004197_abnormal_fetal_growth/weight/0.28689074
141MP0003787_abnormal_imprinting0.25005661
142MP0002152_abnormal_brain_morphology0.24817087
143MP0005551_abnormal_eye_electrophysiolog0.24630981
144MP0003329_amyloid_beta_deposits0.24511219
145MP0005076_abnormal_cell_differentiation0.24389564
146MP0003879_abnormal_hair_cell0.23607875
147MP0006035_abnormal_mitochondrial_morpho0.21965140
148MP0002169_no_abnormal_phenotype0.21073353
149MP0000534_abnormal_ureter_morphology0.21014808
150MP0009672_abnormal_birth_weight0.20920095
151MP0004264_abnormal_extraembryonic_tissu0.20776455
152MP0002873_normal_phenotype0.20714867
153MP0004133_heterotaxia0.19962153
154MP0002086_abnormal_extraembryonic_tissu0.18482005
155MP0004811_abnormal_neuron_physiology0.18410750
156MP0000432_abnormal_head_morphology0.18367160
157MP0005451_abnormal_body_composition0.17671954
158MP0002796_impaired_skin_barrier0.16445849
159MP0000001_mammalian_phenotype0.15792859
160MP0003315_abnormal_perineum_morphology0.15250191

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.19489837
2Abnormal respiratory motile cilium morphology (HP:0005938)8.76874540
3Abnormal respiratory epithelium morphology (HP:0012253)8.76874540
4Rhinitis (HP:0012384)7.95707920
5Chronic bronchitis (HP:0004469)7.27813891
6Abnormal ciliary motility (HP:0012262)7.24203306
7Infertility (HP:0000789)6.44989035
8Nasal polyposis (HP:0100582)6.24113933
9Abnormality of the nasal mucosa (HP:0000433)5.09931494
10Hypoplasia of the fovea (HP:0007750)4.63092333
11Aplasia/Hypoplasia of the fovea (HP:0008060)4.63092333
12Bronchiectasis (HP:0002110)4.56960524
13Nephronophthisis (HP:0000090)4.56285640
14Bronchitis (HP:0012387)4.44294484
15Abnormality of the fovea (HP:0000493)4.38389108
16Aplasia/Hypoplasia of the macula (HP:0008059)4.37430348
17Patchy hypopigmentation of hair (HP:0011365)4.27005979
18Osteomalacia (HP:0002749)4.20792747
19Aplasia/Hypoplasia affecting the retina (HP:0008061)3.99619962
20White forelock (HP:0002211)3.96753754
21Renal Fanconi syndrome (HP:0001994)3.80812881
22Male infertility (HP:0003251)3.68680583
23Horizontal nystagmus (HP:0000666)3.67909469
24Abnormal spermatogenesis (HP:0008669)3.49702864
25Abnormality of the renal medulla (HP:0100957)3.44701559
26Abnormality of the lower motor neuron (HP:0002366)3.35608101
27Recurrent otitis media (HP:0000403)3.26456690
28Recurrent sinusitis (HP:0011108)3.17051110
29Proximal tubulopathy (HP:0000114)3.17026493
30Abnormal auditory evoked potentials (HP:0006958)3.11344151
31Gonadotropin excess (HP:0000837)3.04982200
32Generalized hypopigmentation (HP:0007513)2.97930503
33Ocular albinism (HP:0001107)2.95460632
34Tubulointerstitial nephritis (HP:0001970)2.92577459
35Cutaneous melanoma (HP:0012056)2.90937678
36Abnormality of renal resorption (HP:0011038)2.86607153
37Impulsivity (HP:0100710)2.85933491
38Atrophic scars (HP:0001075)2.78707042
39Azoospermia (HP:0000027)2.78294628
40Abnormality of the costochondral junction (HP:0000919)2.77136969
41Molar tooth sign on MRI (HP:0002419)2.75481803
42Abnormality of midbrain morphology (HP:0002418)2.75481803
43Tubular atrophy (HP:0000092)2.73394631
44Lip pit (HP:0100267)2.69313893
45Septate vagina (HP:0001153)2.66660127
46Symptomatic seizures (HP:0011145)2.64622417
47Amyotrophic lateral sclerosis (HP:0007354)2.60363899
48Recurrent bronchitis (HP:0002837)2.55281545
49Hypoglycemic seizures (HP:0002173)2.55053412
50Type I transferrin isoform profile (HP:0003642)2.48982096
51Tubulointerstitial abnormality (HP:0001969)2.47961416
52Medial flaring of the eyebrow (HP:0010747)2.47085429
53Menstrual irregularities (HP:0000858)2.45509850
54Spinal muscular atrophy (HP:0007269)2.44795992
55Resting tremor (HP:0002322)2.40195900
56Iris hypopigmentation (HP:0007730)2.39221956
57Hypokinesia (HP:0002375)2.37093349
58Insulin-resistant diabetes mellitus (HP:0000831)2.36751162
59Hyperinsulinemic hypoglycemia (HP:0000825)2.35529659
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34671957
61Scotoma (HP:0000575)2.33486918
62Acute necrotizing encephalopathy (HP:0006965)2.31823461
63Prolonged neonatal jaundice (HP:0006579)2.31372850
64Fibular hypoplasia (HP:0003038)2.25616727
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24920989
66Abnormal protein N-linked glycosylation (HP:0012347)2.24920989
67Abnormal protein glycosylation (HP:0012346)2.24920989
68Abnormal glycosylation (HP:0012345)2.24920989
69Rickets (HP:0002748)2.24012041
70Fatigue (HP:0012378)2.24010877
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21641478
72Progressive macrocephaly (HP:0004481)2.21439086
73Fragile nails (HP:0001808)2.19080070
74Deep philtrum (HP:0002002)2.19011513
75Sensory axonal neuropathy (HP:0003390)2.17657881
76Hypopigmentation of the fundus (HP:0007894)2.15804242
77Hypoglycemic coma (HP:0001325)2.13947521
78Blue irides (HP:0000635)2.10576847
79Hypothermia (HP:0002045)2.09836045
80Postaxial foot polydactyly (HP:0001830)2.09646666
81Reduced antithrombin III activity (HP:0001976)2.07385792
82Abnormal mitochondria in muscle tissue (HP:0008316)2.03992119
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.03513820
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03513820
85Buphthalmos (HP:0000557)2.03372317
86Ankle contracture (HP:0006466)2.03372282
87Increased CSF lactate (HP:0002490)2.02863318
88Volvulus (HP:0002580)2.02694842
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02423132
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02423132
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3131730
92Absent/shortened dynein arms (HP:0200106)12.4693577
93Dynein arm defect of respiratory motile cilia (HP:0012255)12.4693577
94Diminished movement (HP:0002374)1.98528407
95Hypoplasia of dental enamel (HP:0006297)1.97952221
96Redundant skin (HP:0001582)1.97765199
97Impaired proprioception (HP:0010831)1.97312085
98Tubulointerstitial fibrosis (HP:0005576)1.96914803
99Asymmetric septal hypertrophy (HP:0001670)1.94685745
100Freckling (HP:0001480)1.93665590
101Stage 5 chronic kidney disease (HP:0003774)1.93230329
102Congenital sensorineural hearing impairment (HP:0008527)1.91762317
103Generalized aminoaciduria (HP:0002909)1.91522479
104Congenital glaucoma (HP:0001087)1.90324528
105Upper motor neuron abnormality (HP:0002127)1.89339301
106Short ribs (HP:0000773)1.88924736
107Upper limb muscle weakness (HP:0003484)1.88098937
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87282030
109Heterotopia (HP:0002282)1.87018782
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85135888
111Microglossia (HP:0000171)1.85061346
112Supernumerary spleens (HP:0009799)1.85012560
113Congenital hepatic fibrosis (HP:0002612)1.83188050
114Polydipsia (HP:0001959)1.83164084
115Abnormal drinking behavior (HP:0030082)1.83164084
116Onycholysis (HP:0001806)1.82866338
117Spastic tetraparesis (HP:0001285)1.81863302
118Abnormality of the anterior horn cell (HP:0006802)1.81833284
119Degeneration of anterior horn cells (HP:0002398)1.81833284
120Hyponatremia (HP:0002902)1.79966584
121Oculomotor apraxia (HP:0000657)1.78809954
122Abnormality of the renal cortex (HP:0011035)1.77649790
123Acute encephalopathy (HP:0006846)1.76969038
124Short nail (HP:0001799)1.76684209
125Enlarged epiphyses (HP:0010580)1.75502980
126Large for gestational age (HP:0001520)1.73555159
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73477471
128Absent epiphyses (HP:0010577)1.73477471
129Hypergonadotropic hypogonadism (HP:0000815)1.72055722
130Steatorrhea (HP:0002570)1.71199064
131Renal dysplasia (HP:0000110)1.69955870
132Follicular hyperkeratosis (HP:0007502)1.69533286
133Abnormality of macular pigmentation (HP:0008002)1.68714596
134Hyperkalemia (HP:0002153)1.68264117
135Poor suck (HP:0002033)1.67858631
136Hypoplasia of the uterus (HP:0000013)1.67703755
137Hyperparathyroidism (HP:0000843)1.66798590
138Abnormality of the corticospinal tract (HP:0002492)1.66686033
139Facial cleft (HP:0002006)1.66513847
140Mitochondrial inheritance (HP:0001427)1.66146784
141Abnormality of permanent molar morphology (HP:0011071)1.63338584
142Abnormality of the dental root (HP:0006486)1.63338584
143Taurodontia (HP:0000679)1.63338584
144Abnormal gallbladder physiology (HP:0012438)1.63223910
145Cholecystitis (HP:0001082)1.63223910
146Absent frontal sinuses (HP:0002688)1.62364464
147Postaxial hand polydactyly (HP:0001162)1.57392759
148Abnormality of renal excretion (HP:0011036)1.56785503
149Abnormality of dentin (HP:0010299)1.56520090
150Abnormality of molar (HP:0011077)1.51509654
151Abnormality of molar morphology (HP:0011070)1.51509654
152J-shaped sella turcica (HP:0002680)1.50936262
153Bell-shaped thorax (HP:0001591)1.49542845
154Median cleft lip (HP:0000161)1.49296911
155Abnormality of the dental pulp (HP:0006479)1.48087581
156Pancreatic fibrosis (HP:0100732)1.46985875
157Chronic sinusitis (HP:0011109)1.45589112
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.45000069
159Dyschromatopsia (HP:0007641)1.44681870
160Abdominal situs inversus (HP:0003363)1.43434565
161Abnormality of abdominal situs (HP:0011620)1.43434565
162Broad distal phalanx of finger (HP:0009836)1.41244470
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41237335
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.41082842
165Abnormal biliary tract physiology (HP:0012439)1.39532302
166Bile duct proliferation (HP:0001408)1.39532302
167Cystic liver disease (HP:0006706)1.38186469
168Short thorax (HP:0010306)1.37783698
16911 pairs of ribs (HP:0000878)1.34742865
170Abnormality of ocular smooth pursuit (HP:0000617)1.31402850
171Deformed sella turcica (HP:0002681)1.31322440
172Congenital primary aphakia (HP:0007707)1.31264292
173Gait imbalance (HP:0002141)1.29610789
174Breast carcinoma (HP:0003002)1.29580735
175Sloping forehead (HP:0000340)1.24778631
176Short femoral neck (HP:0100864)1.24215823
177Abnormal urine output (HP:0012590)1.24108730
178Conjunctival telangiectasia (HP:0000524)1.22725531
179Nephropathy (HP:0000112)1.21809677
180Choroideremia (HP:0001139)1.19029532
181Aplasia/Hypoplasia of the lens (HP:0008063)1.17963019
182Cerebellar dysplasia (HP:0007033)1.17932612
183Poor coordination (HP:0002370)1.16889115
184Decreased central vision (HP:0007663)1.16336692
185Hemiparesis (HP:0001269)1.14215846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.61475238
2PDK38.61475238
3PDK25.57892603
4TESK15.30320797
5PRKD34.04385328
6ICK3.54723412
7PBK2.96378067
8INSRR2.75703816
9NEK12.60557728
10MST1R2.56665667
11PLK22.52045103
12TRIM282.44365137
13NEK22.37842062
14PTK2B2.33080622
15PNCK2.28890444
16MAP3K122.21239948
17WNK42.12614257
18STK392.07050378
19MAP3K21.87480094
20MET1.86111873
21MST41.79511274
22STK381.67525732
23EIF2AK31.64196450
24ARAF1.60406193
25PIK3CG1.51355822
26DDR21.50052789
27STK241.48706858
28STK161.44141368
29FRK1.38915561
30CDK191.34210806
31WEE11.22905311
32MYLK1.20602792
33MAP3K31.18935200
34SCYL21.18891752
35DYRK31.13790853
36CDC71.11572590
37STK31.04799348
38MAP4K21.02566504
39TTK1.00124008
40DYRK1B0.98197864
41CCNB10.96412278
42TYRO30.95350119
43WNK10.90632386
44PDK10.89770802
45ABL20.87449561
46BMPR20.87104950
47MAPK150.84521907
48PASK0.83845285
49KSR20.79997725
50CDK120.79973851
51PTK20.79296712
52CHEK20.77112187
53LIMK10.75945125
54PRKCI0.73846328
55PHKG10.70907252
56PHKG20.70907252
57KSR10.69130891
58PIM20.69112302
59PLK40.68067495
60CHEK10.66795391
61PINK10.64166827
62TESK20.62880569
63SIK30.62818481
64STK38L0.60101865
65ATR0.58866668
66FER0.58573080
67MAP3K90.57510754
68IRAK10.55633419
69PLK10.55228361
70BRSK20.54320842
71NTRK30.54243974
72ADRBK10.53182257
73GRK10.52710613
74CAMK1G0.51639044
75CLK10.48612616
76NME20.48499897
77MAP3K10.48385896
78BCR0.47042628
79ATM0.44139448
80NME10.42081259
81AKT20.41694875
82PAK10.40394255
83YES10.39803304
84EEF2K0.39540964
85MTOR0.38488442
86BUB10.38477317
87IRAK30.37913431
88LMTK20.37614257
89PDPK10.37005503
90TRPM70.36430688
91GRK50.36413560
92RAF10.34679382
93TGFBR20.33970529
94ADRBK20.33884578
95STK40.33367623
96ERBB30.33140807
97PRKG20.33099682
98RPS6KB20.32359377
99GRK70.31592357
100PRKAA10.29950923
101MAP2K60.29894269
102MAP3K80.26970139
103PAK20.26762442
104NEK90.25577330
105BRSK10.22364470
106CDK40.20933035
107IRAK20.20384574
108PRKCG0.19596261
109NTRK20.19388357
110NEK60.19193062
111CDK20.18970661
112MUSK0.18806050
113MARK30.18173124
114CDK10.16001973
115RPS6KB10.15977542
116AURKB0.15938782
117BMPR1B0.15873087
118CDK30.15181996
119PAK60.13648932
120RIPK40.12172155
121AURKA0.11758408
122LATS20.11747252
123CAMKK10.11703259
124BRAF0.11204596
125CDK70.11113006
126SRPK10.11009862
127EIF2AK10.10641925
128CSNK2A10.10611977
129WNK30.10516411
130ACVR1B0.10420396
131GSK3B0.09078937
132PAK40.08103595
133STK100.08024378
134CSNK1D0.07954372
135ZAP700.07311089
136CSNK2A20.05410641
137MARK20.05230377
138MAP3K40.04677721
139CDK150.04355305
140MAPK80.04262125
141MAP3K50.03971832
142PRKDC0.03434752
143CDK60.02286949
144CDK180.01664093
145CDK11A0.01608412
146MAPK100.01481776
147AKT30.01479384
148PRKACB0.01331142
149MAPKAPK50.00942901
150RPS6KA10.00893638
151PRKCZ0.00836660
152PRKG10.00387811
153STK110.00368139
154LATS1-0.0104196
155PIM1-0.0091935
156MAPK1-0.0066584
157PLK3-0.0066401
158CDK9-0.0040428

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.98571819
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.88912491
3Pyruvate metabolism_Homo sapiens_hsa006203.72674665
4Protein export_Homo sapiens_hsa030603.59472747
5Basal transcription factors_Homo sapiens_hsa030223.35440773
6Fatty acid biosynthesis_Homo sapiens_hsa000613.19182220
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.04111741
8Fanconi anemia pathway_Homo sapiens_hsa034602.91675687
9Propanoate metabolism_Homo sapiens_hsa006402.79740134
10Glucagon signaling pathway_Homo sapiens_hsa049222.71650732
11Selenocompound metabolism_Homo sapiens_hsa004502.66541485
12Folate biosynthesis_Homo sapiens_hsa007902.57280692
13Pentose phosphate pathway_Homo sapiens_hsa000302.56457343
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54799359
15Oxidative phosphorylation_Homo sapiens_hsa001902.54602677
16Linoleic acid metabolism_Homo sapiens_hsa005912.47737721
17Regulation of autophagy_Homo sapiens_hsa041402.43893008
18Oocyte meiosis_Homo sapiens_hsa041142.34934051
19Dorso-ventral axis formation_Homo sapiens_hsa043202.31961483
20RNA transport_Homo sapiens_hsa030132.05621852
21Parkinsons disease_Homo sapiens_hsa050121.97215300
22Glycerolipid metabolism_Homo sapiens_hsa005611.92302335
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88950004
24mRNA surveillance pathway_Homo sapiens_hsa030151.88547427
25Ribosome_Homo sapiens_hsa030101.87568819
26Fatty acid elongation_Homo sapiens_hsa000621.83501344
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78280585
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74217849
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.66802658
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65876810
31Sulfur metabolism_Homo sapiens_hsa009201.64035954
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63353919
33Huntingtons disease_Homo sapiens_hsa050161.59757978
34RNA polymerase_Homo sapiens_hsa030201.58893473
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.52304786
36Amphetamine addiction_Homo sapiens_hsa050311.45823464
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45408142
38PPAR signaling pathway_Homo sapiens_hsa033201.44536308
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44372623
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42316961
41Carbon metabolism_Homo sapiens_hsa012001.37538309
42Fructose and mannose metabolism_Homo sapiens_hsa000511.37430074
43One carbon pool by folate_Homo sapiens_hsa006701.36940865
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36376697
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.30602213
46Alzheimers disease_Homo sapiens_hsa050101.26014868
47Purine metabolism_Homo sapiens_hsa002301.25651055
48Antigen processing and presentation_Homo sapiens_hsa046121.13685610
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10075340
50Ether lipid metabolism_Homo sapiens_hsa005651.09886612
51Cardiac muscle contraction_Homo sapiens_hsa042601.08359315
52Biosynthesis of amino acids_Homo sapiens_hsa012301.06723230
53Fat digestion and absorption_Homo sapiens_hsa049751.05686817
54Sphingolipid metabolism_Homo sapiens_hsa006001.04935596
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04369221
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01402746
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00076764
58Cell cycle_Homo sapiens_hsa041100.98850172
59Renin secretion_Homo sapiens_hsa049240.98245424
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95582339
61Homologous recombination_Homo sapiens_hsa034400.93042435
62Circadian rhythm_Homo sapiens_hsa047100.92390354
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91798675
64Mineral absorption_Homo sapiens_hsa049780.91791086
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91258248
66Tyrosine metabolism_Homo sapiens_hsa003500.90997747
67Vibrio cholerae infection_Homo sapiens_hsa051100.90876721
68Synaptic vesicle cycle_Homo sapiens_hsa047210.89394383
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86236508
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85194198
71Glutathione metabolism_Homo sapiens_hsa004800.83089468
72Fatty acid metabolism_Homo sapiens_hsa012120.82600549
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81344698
74Lysosome_Homo sapiens_hsa041420.77646940
75Sulfur relay system_Homo sapiens_hsa041220.77548635
76Fatty acid degradation_Homo sapiens_hsa000710.76629270
77Pyrimidine metabolism_Homo sapiens_hsa002400.76482721
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74285501
79DNA replication_Homo sapiens_hsa030300.73911658
80RNA degradation_Homo sapiens_hsa030180.71098685
81Long-term potentiation_Homo sapiens_hsa047200.70945803
82Systemic lupus erythematosus_Homo sapiens_hsa053220.70647308
83Arginine and proline metabolism_Homo sapiens_hsa003300.68711831
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68671873
85Spliceosome_Homo sapiens_hsa030400.65399755
86Small cell lung cancer_Homo sapiens_hsa052220.64694699
87TGF-beta signaling pathway_Homo sapiens_hsa043500.62374257
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61444513
89Estrogen signaling pathway_Homo sapiens_hsa049150.60326491
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60019488
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.59794977
92Hedgehog signaling pathway_Homo sapiens_hsa043400.59699770
93Butanoate metabolism_Homo sapiens_hsa006500.59060652
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58588021
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58515632
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.56152011
97ABC transporters_Homo sapiens_hsa020100.55447045
98Arachidonic acid metabolism_Homo sapiens_hsa005900.55396930
99AMPK signaling pathway_Homo sapiens_hsa041520.54342118
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.50730977
101Nucleotide excision repair_Homo sapiens_hsa034200.49866945
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49091987
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47877159
104Steroid biosynthesis_Homo sapiens_hsa001000.47853270
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47151870
106ECM-receptor interaction_Homo sapiens_hsa045120.47056033
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46759685
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46377911
109Inositol phosphate metabolism_Homo sapiens_hsa005620.45956404
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44653575
111Chemical carcinogenesis_Homo sapiens_hsa052040.44620989
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43607014
113Legionellosis_Homo sapiens_hsa051340.43179547
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43134310
115Peroxisome_Homo sapiens_hsa041460.42754369
116VEGF signaling pathway_Homo sapiens_hsa043700.38710812
117Endocytosis_Homo sapiens_hsa041440.38476039
118Calcium signaling pathway_Homo sapiens_hsa040200.38454496
119Viral carcinogenesis_Homo sapiens_hsa052030.38406164
120mTOR signaling pathway_Homo sapiens_hsa041500.37372661
121Collecting duct acid secretion_Homo sapiens_hsa049660.36664505
122Metabolic pathways_Homo sapiens_hsa011000.36117043
123Renin-angiotensin system_Homo sapiens_hsa046140.34171241
124Epstein-Barr virus infection_Homo sapiens_hsa051690.33573122
125N-Glycan biosynthesis_Homo sapiens_hsa005100.32182079
126Thyroid hormone synthesis_Homo sapiens_hsa049180.31908151
127Insulin secretion_Homo sapiens_hsa049110.30674960
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30514248
129Base excision repair_Homo sapiens_hsa034100.29378260
130p53 signaling pathway_Homo sapiens_hsa041150.29176322
131Alcoholism_Homo sapiens_hsa050340.29121336
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.29002652
133Phenylalanine metabolism_Homo sapiens_hsa003600.28983285
134Proteasome_Homo sapiens_hsa030500.27839423
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26145383
136Bile secretion_Homo sapiens_hsa049760.24476011
137Olfactory transduction_Homo sapiens_hsa047400.23739521
138Prostate cancer_Homo sapiens_hsa052150.21911030
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21713498
140Wnt signaling pathway_Homo sapiens_hsa043100.20835314
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.19644595
142Type II diabetes mellitus_Homo sapiens_hsa049300.19112254
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18882828
144Taste transduction_Homo sapiens_hsa047420.16572802
145Mismatch repair_Homo sapiens_hsa034300.16277429
146Protein digestion and absorption_Homo sapiens_hsa049740.13281581
147Pancreatic secretion_Homo sapiens_hsa049720.13099179
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12597290
149Non-homologous end-joining_Homo sapiens_hsa034500.10700294

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