SPG21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06432313
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.53715871
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.53715871
4modulation by symbiont of host immune response (GO:0052553)4.53715871
5positive regulation by symbiont of host defense response (GO:0052509)4.53715871
6modulation by symbiont of host defense response (GO:0052031)4.53715871
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.53715871
8Arp2/3 complex-mediated actin nucleation (GO:0034314)4.37358421
9ribosomal small subunit assembly (GO:0000028)4.30566049
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17618133
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17618133
12viral transcription (GO:0019083)3.91210400
13antigen processing and presentation of endogenous antigen (GO:0019883)3.80335188
14DNA deamination (GO:0045006)3.76111958
15translational termination (GO:0006415)3.75346860
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56404142
17negative regulation of interleukin-12 production (GO:0032695)3.56346534
18regulation of mast cell degranulation (GO:0043304)3.55425195
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49762520
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39226131
21protein targeting to ER (GO:0045047)3.38198196
22response to interferon-beta (GO:0035456)3.37392462
23cotranslational protein targeting to membrane (GO:0006613)3.36036950
24translational elongation (GO:0006414)3.33093034
25detection of other organism (GO:0098543)3.32651951
26macrophage activation involved in immune response (GO:0002281)3.30157144
27negative regulation of phagocytosis (GO:0050765)3.25444703
28response to host immune response (GO:0052572)3.24744972
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24744972
30protein localization to endoplasmic reticulum (GO:0070972)3.24454618
31regulation of mast cell activation involved in immune response (GO:0033006)3.21905695
32immunoglobulin mediated immune response (GO:0016064)3.20004958
33positive regulation of mast cell activation (GO:0033005)3.19657195
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19058090
35detection of bacterium (GO:0016045)3.18661141
36positive regulation of mast cell degranulation (GO:0043306)3.17821324
37positive regulation of mast cell activation involved in immune response (GO:0033008)3.17821324
38antigen processing and presentation via MHC class Ib (GO:0002475)3.16424552
39regulation of mast cell activation (GO:0033003)3.11756920
40actin nucleation (GO:0045010)3.11488937
41viral life cycle (GO:0019058)3.09312772
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08199322
43translational initiation (GO:0006413)2.99890214
44amino sugar catabolic process (GO:0046348)2.98742294
45pentose-phosphate shunt (GO:0006098)2.98054257
46cellular response to interferon-beta (GO:0035458)2.97381710
47B cell mediated immunity (GO:0019724)2.97355233
48regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96898650
49neutrophil activation (GO:0042119)2.95661967
50regulation of leukocyte degranulation (GO:0043300)2.95616679
51cellular extravasation (GO:0045123)2.94818675
52positive regulation of antigen processing and presentation (GO:0002579)2.92099758
53response to host (GO:0075136)2.91780081
54response to host defenses (GO:0052200)2.91780081
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91780081
56granulocyte activation (GO:0036230)2.91148258
57amyloid precursor protein catabolic process (GO:0042987)2.90472614
58response to interferon-alpha (GO:0035455)2.90005428
59purine deoxyribonucleotide catabolic process (GO:0009155)2.89786633
60detection of external biotic stimulus (GO:0098581)2.87118991
61endosome to pigment granule transport (GO:0043485)2.86998502
62endosome to melanosome transport (GO:0035646)2.86998502
63formation of translation preinitiation complex (GO:0001731)2.86402193
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85629612
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85118155
66glycosphingolipid catabolic process (GO:0046479)2.81432859
67maturation of SSU-rRNA (GO:0030490)2.81380344
68positive regulation of interferon-alpha production (GO:0032727)2.80875804
69NADPH regeneration (GO:0006740)2.80539114
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80399805
71microglial cell activation (GO:0001774)2.80098482
72phagosome maturation (GO:0090382)2.79963333
73positive regulation of gamma-delta T cell activation (GO:0046645)2.78250218
74ribosomal small subunit biogenesis (GO:0042274)2.77200004
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77136579
76barbed-end actin filament capping (GO:0051016)2.77026939
77pentose metabolic process (GO:0019321)2.75744200
78positive regulation of lamellipodium assembly (GO:0010592)2.75649406
79cellular protein complex disassembly (GO:0043624)2.74202093
80response to type I interferon (GO:0034340)2.72772877
81detection of molecule of bacterial origin (GO:0032490)2.72213419
82type I interferon signaling pathway (GO:0060337)2.72039408
83cellular response to type I interferon (GO:0071357)2.72039408
84myeloid cell activation involved in immune response (GO:0002275)2.71925685
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70836559
86autophagic vacuole fusion (GO:0000046)2.70679904
87cellular response to zinc ion (GO:0071294)2.69412492
88base-excision repair, AP site formation (GO:0006285)2.68960881
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68906399
90deoxyribonucleotide catabolic process (GO:0009264)2.68750668
91ribosomal large subunit biogenesis (GO:0042273)2.68552892
92negative regulation of B cell apoptotic process (GO:0002903)2.67497927
93regulation of hypersensitivity (GO:0002883)2.67110746
94negative regulation of cell killing (GO:0031342)2.66632471
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66632471
96regulation of protein heterodimerization activity (GO:0043497)2.66535888
97neutrophil activation involved in immune response (GO:0002283)2.65902122
98telomere maintenance via semi-conservative replication (GO:0032201)2.65853817
99macrophage activation (GO:0042116)2.64798645
100platelet dense granule organization (GO:0060155)2.64345077
101regulation of interferon-alpha production (GO:0032647)2.63293223
102reactive oxygen species biosynthetic process (GO:1903409)2.62346444
103deoxyribose phosphate catabolic process (GO:0046386)2.60946705
104positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.58815893
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58245507
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58169811
107glycolipid catabolic process (GO:0019377)2.57396324
108hydrogen peroxide biosynthetic process (GO:0050665)2.57294199
109neutrophil mediated immunity (GO:0002446)2.56736892
110regulation of B cell apoptotic process (GO:0002902)2.56334746
111positive regulation of leukocyte degranulation (GO:0043302)2.56145120
112detection of biotic stimulus (GO:0009595)2.56134383
113pyrimidine nucleotide catabolic process (GO:0006244)2.55107987
114DNA strand elongation involved in DNA replication (GO:0006271)2.54078054
115positive regulation of regulated secretory pathway (GO:1903307)2.53461457
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53413549
117positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.52660086
118oligosaccharide catabolic process (GO:0009313)2.52480333
119cellular response to thyroid hormone stimulus (GO:0097067)2.52313208
120positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.50439987
121regulation of regulated secretory pathway (GO:1903305)2.49771689
122regulation of response to interferon-gamma (GO:0060330)2.48904082
123negative regulation of granulocyte differentiation (GO:0030853)2.47298613
124lysosome organization (GO:0007040)2.47026447
125lytic vacuole organization (GO:0080171)2.47026447
126polyketide metabolic process (GO:0030638)2.46274253
127doxorubicin metabolic process (GO:0044598)2.46274253
128daunorubicin metabolic process (GO:0044597)2.46274253
129regulation of interferon-beta biosynthetic process (GO:0045357)2.45066819
130defense response to protozoan (GO:0042832)2.45032377
131leukocyte degranulation (GO:0043299)2.43711810
132response to xenobiotic stimulus (GO:0009410)2.43676344
133protein complex disassembly (GO:0043241)2.42266972
134regulation of superoxide anion generation (GO:0032928)2.42207862
135regulation of B cell receptor signaling pathway (GO:0050855)2.42178868
136killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.41766383
137disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.41766383
138sequestering of actin monomers (GO:0042989)2.41230828
139response to peptidoglycan (GO:0032494)2.40771989
140purine-containing compound salvage (GO:0043101)2.39815880
141regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.39540807
142regulation of monocyte differentiation (GO:0045655)2.38955887
143negative regulation of interleukin-6 production (GO:0032715)2.38791572
144DNA strand elongation (GO:0022616)2.38499508
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.37500809
146ceramide catabolic process (GO:0046514)2.36646848
147glycoside metabolic process (GO:0016137)2.35932403
148respiratory burst (GO:0045730)2.34712900
149telomere maintenance via recombination (GO:0000722)2.32906178
150pinocytosis (GO:0006907)2.32603933
151response to protozoan (GO:0001562)2.31954680
152antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.31527300
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.29960628
154protein targeting to membrane (GO:0006612)2.28580989
155translation (GO:0006412)2.27702511
156positive regulation of lamellipodium organization (GO:1902745)2.27341749
157positive regulation of B cell differentiation (GO:0045579)2.27158796
158interferon-gamma-mediated signaling pathway (GO:0060333)2.26740298
159macromolecular complex disassembly (GO:0032984)2.26452556
160leukocyte aggregation (GO:0070486)2.25996504
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25800967
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.21929308
163NIK/NF-kappaB signaling (GO:0038061)2.21422339
164negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.19516731
165ribonucleoprotein complex biogenesis (GO:0022613)2.19199188
166signal peptide processing (GO:0006465)2.18528103
167DNA replication initiation (GO:0006270)2.18432495
168regulation of B cell differentiation (GO:0045577)2.17038928
169positive regulation of interferon-beta production (GO:0032728)2.16705587
170proteasome assembly (GO:0043248)2.16597325
171muscle organ morphogenesis (GO:0048644)2.16561785
172nuclear-transcribed mRNA catabolic process (GO:0000956)2.16015333
173macrophage differentiation (GO:0030225)2.15768490
174T cell apoptotic process (GO:0070231)2.15128765
175Golgi transport vesicle coating (GO:0048200)2.14315057
176COPI coating of Golgi vesicle (GO:0048205)2.14315057
177regulation of antigen processing and presentation (GO:0002577)2.12908106
178morphogenesis of an endothelium (GO:0003159)2.12540000
179endothelial tube morphogenesis (GO:0061154)2.12540000
180dendritic cell differentiation (GO:0097028)2.11716207
181phospholipid scrambling (GO:0017121)2.09827950
182regulation of necroptotic process (GO:0060544)2.09708957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.35998718
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35258213
3* IRF8_22096565_ChIP-ChIP_GC-B_Human2.98857546
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.80064414
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.59302639
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.53161200
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46751917
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40085463
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35746338
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34028709
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.22996453
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21263750
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21063336
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15263995
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10552825
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09697092
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04373645
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00073218
19VDR_21846776_ChIP-Seq_THP-1_Human1.97774849
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93968936
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91654197
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88779224
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87841978
24MYC_22102868_ChIP-Seq_BL_Human1.85408838
25SPI1_23547873_ChIP-Seq_NB4_Human1.83058567
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81949389
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80526709
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.80521083
29SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80036176
30VDR_23849224_ChIP-Seq_CD4+_Human1.77265936
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76870413
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73640711
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.73574827
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72378194
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68702051
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68080537
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.65970982
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65921309
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64248120
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64187343
41XRN2_22483619_ChIP-Seq_HELA_Human1.64063231
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63884517
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63673598
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63151808
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62410448
46DCP1A_22483619_ChIP-Seq_HELA_Human1.62008965
47BCL6_27268052_Chip-Seq_Bcells_Human1.61291887
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60996116
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60201595
50* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57887527
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57759087
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56843204
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54331710
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.53804431
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53428518
56* TFEB_21752829_ChIP-Seq_HELA_Human1.51650049
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51000286
58LXR_22292898_ChIP-Seq_THP-1_Human1.49309906
59* MAF_26560356_Chip-Seq_TH1_Human1.48410240
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48239820
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.47533166
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47279806
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47069908
64SPI1_23127762_ChIP-Seq_K562_Human1.46372859
65MYB_26560356_Chip-Seq_TH2_Human1.46208278
66VDR_24763502_ChIP-Seq_THP-1_Human1.43383634
67FOXP3_21729870_ChIP-Seq_TREG_Human1.42578161
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.42412812
69GABP_19822575_ChIP-Seq_HepG2_Human1.42226011
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40797520
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40796179
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39393530
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38592781
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36025175
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.35123551
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34909549
77ZNF263_19887448_ChIP-Seq_K562_Human1.34645990
78* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33272184
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31781954
80UTX_26944678_Chip-Seq_JUKART_Human1.31648913
81MYB_26560356_Chip-Seq_TH1_Human1.31084231
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30289745
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.29184492
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28471577
85BCOR_27268052_Chip-Seq_Bcells_Human1.27387223
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.27054090
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26818506
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25883842
89ELK1_19687146_ChIP-ChIP_HELA_Human1.25510405
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24683462
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24602856
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23723774
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23204655
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22917319
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22577705
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.22193855
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20664394
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20473694
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18708848
100TTF2_22483619_ChIP-Seq_HELA_Human1.17882606
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17243435
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16921258
103SCL_19346495_ChIP-Seq_HPC-7_Human1.16861608
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16317797
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.15798766
106BP1_19119308_ChIP-ChIP_Hs578T_Human1.15254233
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14770189
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.14384686
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12728561
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12354435
111P68_20966046_ChIP-Seq_HELA_Human1.11755304
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11420418
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.09414748
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08546829
115CLOCK_20551151_ChIP-Seq_293T_Human1.08141403
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06066587
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05552999
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05531340
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05277556
120CIITA_25753668_ChIP-Seq_RAJI_Human1.05063668
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04329400
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03719452
123* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03420742
124E2F1_20622854_ChIP-Seq_HELA_Human1.02397471
125MAF_26560356_Chip-Seq_TH2_Human1.02291963
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.00580694
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00126682
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99446434
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99335284
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98361396
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97255514
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95921775
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95913943
134TCF7_22412390_ChIP-Seq_EML_Mouse0.95422317
135PU_27001747_Chip-Seq_BMDM_Mouse0.95231539
136NCOR1_26117541_ChIP-Seq_K562_Human0.94985829
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.94772517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.24905816
2MP0003806_abnormal_nucleotide_metabolis2.77444832
3MP0009785_altered_susceptibility_to2.74430045
4MP0000685_abnormal_immune_system2.65952579
5MP0005360_urolithiasis2.55339986
6MP0003436_decreased_susceptibility_to2.55094164
7MP0002166_altered_tumor_susceptibility2.28025019
8MP0005058_abnormal_lysosome_morphology2.23167748
9MP0003724_increased_susceptibility_to2.11784267
10MP0005025_abnormal_response_to2.10743648
11MP0008438_abnormal_cutaneous_collagen2.08398254
12MP0006082_CNS_inflammation2.06163352
13MP0005671_abnormal_response_to2.06141583
14MP0005000_abnormal_immune_tolerance1.96447188
15MP0002148_abnormal_hypersensitivity_rea1.94784903
16MP0002452_abnormal_antigen_presenting1.91148233
17MP0002419_abnormal_innate_immunity1.90701864
18MP0003693_abnormal_embryo_hatching1.88127005
19MP0002006_tumorigenesis1.87654993
20MP0002396_abnormal_hematopoietic_system1.84009191
21MP0002139_abnormal_hepatobiliary_system1.81280233
22MP0001800_abnormal_humoral_immune1.80761396
23MP0001853_heart_inflammation1.80705872
24MP0003763_abnormal_thymus_physiology1.78201985
25MP0000372_irregular_coat_pigmentation1.78168379
26MP0003303_peritoneal_inflammation1.77584147
27MP0002420_abnormal_adaptive_immunity1.76563523
28MP0001819_abnormal_immune_cell1.76105723
29MP0000858_altered_metastatic_potential1.74503915
30MP0002723_abnormal_immune_serum1.73909631
31MP0001790_abnormal_immune_system1.73080676
32MP0005387_immune_system_phenotype1.73080676
33MP0008007_abnormal_cellular_replicative1.72702521
34MP0002405_respiratory_system_inflammati1.68684706
35MP0009333_abnormal_splenocyte_physiolog1.68515033
36MP0002132_abnormal_respiratory_system1.67588766
37MP0000490_abnormal_crypts_of1.63852496
38MP0002398_abnormal_bone_marrow1.57991605
39MP0004957_abnormal_blastocyst_morpholog1.57071465
40MP0003183_abnormal_peptide_metabolism1.56796040
41MP0005397_hematopoietic_system_phenotyp1.55979868
42MP0001545_abnormal_hematopoietic_system1.55979868
43MP0000604_amyloidosis1.54541531
44MP0010155_abnormal_intestine_physiology1.51309220
45MP0010352_gastrointestinal_tract_polyps1.51286583
46MP0003191_abnormal_cellular_cholesterol1.50591297
47MP0005464_abnormal_platelet_physiology1.49816523
48MP0000716_abnormal_immune_system1.44816297
49MP0005451_abnormal_body_composition1.44402048
50MP0000371_diluted_coat_color1.44369511
51MP0003186_abnormal_redox_activity1.44324670
52MP0000689_abnormal_spleen_morphology1.44261286
53MP0001873_stomach_inflammation1.43131102
54MP0003300_gastrointestinal_ulcer1.43113425
55MP0006054_spinal_hemorrhage1.42625990
56MP0001533_abnormal_skeleton_physiology1.40611790
57MP0001845_abnormal_inflammatory_respons1.39590776
58MP0002722_abnormal_immune_system1.39327953
59MP0004947_skin_inflammation1.38671235
60MP0010307_abnormal_tumor_latency1.37250684
61MP0009840_abnormal_foam_cell1.35796163
62MP0003448_altered_tumor_morphology1.35578506
63MP0004808_abnormal_hematopoietic_stem1.34607917
64MP0002429_abnormal_blood_cell1.32923026
65MP0001764_abnormal_homeostasis1.28160522
66MP0005365_abnormal_bile_salt1.27027276
67MP0002877_abnormal_melanocyte_morpholog1.24367357
68MP0003656_abnormal_erythrocyte_physiolo1.24182444
69MP0003705_abnormal_hypodermis_morpholog1.23801244
70MP0002653_abnormal_ependyma_morphology1.22119807
71MP0000343_altered_response_to1.21746004
72MP0000465_gastrointestinal_hemorrhage1.20515851
73MP0008469_abnormal_protein_level1.19343745
74MP0000015_abnormal_ear_pigmentation1.18890508
75MP0005023_abnormal_wound_healing1.17275779
76MP0003077_abnormal_cell_cycle1.14983002
77MP0003172_abnormal_lysosome_physiology1.14607440
78MP0005085_abnormal_gallbladder_physiolo1.13661451
79MP0003075_altered_response_to1.13604102
80MP0002019_abnormal_tumor_incidence1.11979237
81MP0008260_abnormal_autophagy1.11674937
82MP0010094_abnormal_chromosome_stability1.11092489
83MP0001958_emphysema1.09605150
84MP0005174_abnormal_tail_pigmentation1.09358232
85MP0003566_abnormal_cell_adhesion1.06674846
86MP0005319_abnormal_enzyme/_coenzyme1.06491572
87MP0009278_abnormal_bone_marrow1.05956114
88MP0000703_abnormal_thymus_morphology1.05374168
89MP0002095_abnormal_skin_pigmentation1.02110330
90MP0004147_increased_porphyrin_level1.00527494
91MP0005257_abnormal_intraocular_pressure0.99886316
92MP0001542_abnormal_bone_strength0.98998618
93MP0002933_joint_inflammation0.98890093
94MP0004782_abnormal_surfactant_physiolog0.98437810
95MP0008875_abnormal_xenobiotic_pharmacok0.97440320
96MP0000609_abnormal_liver_physiology0.94503946
97MP0005075_abnormal_melanosome_morpholog0.92164380
98MP0003111_abnormal_nucleus_morphology0.90584582
99MP0003828_pulmonary_edema0.90413692
100MP0003195_calcinosis0.88228809
101MP0009643_abnormal_urine_homeostasis0.88110212
102MP0005310_abnormal_salivary_gland0.88065973
103MP0005584_abnormal_enzyme/coenzyme_acti0.87183794
104MP0004883_abnormal_blood_vessel0.85122971
105MP0002277_abnormal_respiratory_mucosa0.84054535
106MP0003866_abnormal_defecation0.83590157
107MP0002138_abnormal_hepatobiliary_system0.83079880
108MP0001348_abnormal_lacrimal_gland0.82942675
109MP0009764_decreased_sensitivity_to0.82516808
110MP0003011_delayed_dark_adaptation0.79394539
111MP0009379_abnormal_foot_pigmentation0.79324424
112MP0000681_abnormal_thyroid_gland0.79227685
113MP0005164_abnormal_response_to0.78550112
114MP0003786_premature_aging0.77619384
115MP0003453_abnormal_keratinocyte_physiol0.77572321
116MP0002163_abnormal_gland_morphology0.76898768
117MP0009765_abnormal_xenobiotic_induced0.76735050
118MP0005390_skeleton_phenotype0.76555664
119MP0003638_abnormal_response/metabolism_0.76507438
120MP0006036_abnormal_mitochondrial_physio0.75929415
121MP0008058_abnormal_DNA_repair0.75286956
122MP0001663_abnormal_digestive_system0.74691396
123MP0003279_aneurysm0.73634568
124MP0004510_myositis0.73191622
125MP0000313_abnormal_cell_death0.73101007
126MP0009763_increased_sensitivity_to0.72572512
127MP0000477_abnormal_intestine_morphology0.72036006
128MP0002075_abnormal_coat/hair_pigmentati0.71855888
129MP0003329_amyloid_beta_deposits0.71213646
130MP0005379_endocrine/exocrine_gland_phen0.70232558
131MP0000350_abnormal_cell_proliferation0.69479629
132MP0000358_abnormal_cell_content/0.69091610
133MP0002254_reproductive_system_inflammat0.68873358
134MP0002998_abnormal_bone_remodeling0.68814527
135MP0005408_hypopigmentation0.68685161
136MP0003795_abnormal_bone_structure0.68663734
137MP0000750_abnormal_muscle_regeneration0.68526532
138MP0002118_abnormal_lipid_homeostasis0.68044629
139MP0001756_abnormal_urination0.66439139

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.25230446
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.25230446
3Abnormality of glycolipid metabolism (HP:0010969)6.25230446
4Elevated erythrocyte sedimentation rate (HP:0003565)4.58374136
5Recurrent abscess formation (HP:0002722)3.97678350
6Vacuolated lymphocytes (HP:0001922)3.97054553
7Eczematoid dermatitis (HP:0000976)3.96754369
8Thrombocytosis (HP:0001894)3.74716117
9Myositis (HP:0100614)3.48569545
10Abnormality of macrophages (HP:0004311)3.41748004
11Stomatitis (HP:0010280)3.41151606
12Nasal polyposis (HP:0100582)3.31236774
13Recurrent bacterial skin infections (HP:0005406)3.30394964
14Interstitial pulmonary disease (HP:0006530)3.11705876
15Abnormality of the nasal mucosa (HP:0000433)3.10090282
16Increased cerebral lipofuscin (HP:0011813)3.08121578
17Increased neuronal autofluorescent lipopigment (HP:0002074)2.94320541
18Dysostosis multiplex (HP:0000943)2.92390176
19Reticulocytopenia (HP:0001896)2.91423199
20Abnormality of cells of the erythroid lineage (HP:0012130)2.87716496
21Abnormal number of erythroid precursors (HP:0012131)2.82231818
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82058621
23Recurrent gram-negative bacterial infections (HP:0005420)2.80616126
24J-shaped sella turcica (HP:0002680)2.79057189
25Vertebral compression fractures (HP:0002953)2.78773606
26IgM deficiency (HP:0002850)2.77124597
27Recurrent fungal infections (HP:0002841)2.73407803
28Reduced antithrombin III activity (HP:0001976)2.71816740
29Poor head control (HP:0002421)2.64928340
30Chronic otitis media (HP:0000389)2.62384112
31Urinary glycosaminoglycan excretion (HP:0003541)2.61215579
32Mucopolysacchariduria (HP:0008155)2.61215579
33Retrobulbar optic neuritis (HP:0100654)2.59926308
34Optic neuritis (HP:0100653)2.59926308
35Autoimmune thrombocytopenia (HP:0001973)2.58760697
36Generalized aminoaciduria (HP:0002909)2.56185459
37Disinhibition (HP:0000734)2.56042828
38Recurrent bronchitis (HP:0002837)2.54248331
39Mediastinal lymphadenopathy (HP:0100721)2.53758841
40Abnormality of iron homeostasis (HP:0011031)2.53757510
41Petechiae (HP:0000967)2.52534516
42Abnormality of T cell physiology (HP:0011840)2.50896765
43Prolonged neonatal jaundice (HP:0006579)2.45654025
44Multiple enchondromatosis (HP:0005701)2.44829394
45Upper motor neuron abnormality (HP:0002127)2.42680557
46Cardiomegaly (HP:0001640)2.38603898
47Mutism (HP:0002300)2.37342904
48Orchitis (HP:0100796)2.36272440
49Recurrent viral infections (HP:0004429)2.34673615
50Beaking of vertebral bodies (HP:0004568)2.34160138
51Loss of speech (HP:0002371)2.31106786
52Recurrent skin infections (HP:0001581)2.30381623
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28395975
54Abnormality of polysaccharide metabolism (HP:0011012)2.28395975
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28395975
56Encephalitis (HP:0002383)2.26118133
57Abnormality of the anterior horn cell (HP:0006802)2.25341510
58Degeneration of anterior horn cells (HP:0002398)2.25341510
59Obstructive lung disease (HP:0006536)2.24548206
60Chronic obstructive pulmonary disease (HP:0006510)2.24548206
61Protrusio acetabuli (HP:0003179)2.21794192
62Pustule (HP:0200039)2.19849552
63Cervical subluxation (HP:0003308)2.19197054
64Abnormality of T cells (HP:0002843)2.18533578
65Type I transferrin isoform profile (HP:0003642)2.18341008
66Albinism (HP:0001022)2.17845194
67Purpura (HP:0000979)2.17784775
68Abnormality of transition element cation homeostasis (HP:0011030)2.17283950
69Agammaglobulinemia (HP:0004432)2.13620045
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.10651471
71IgG deficiency (HP:0004315)2.10097685
72Pallor (HP:0000980)2.09955520
73Hematochezia (HP:0002573)2.08832978
74Eosinophilia (HP:0001880)2.08467742
75Microretrognathia (HP:0000308)2.06749838
76Granulocytopenia (HP:0001913)2.06495214
77Abnormal protein glycosylation (HP:0012346)2.06422704
78Abnormal glycosylation (HP:0012345)2.06422704
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06422704
80Abnormal protein N-linked glycosylation (HP:0012347)2.06422704
81Amyloidosis (HP:0011034)2.04987350
82Hemoptysis (HP:0002105)2.04484675
83Cellulitis (HP:0100658)2.04264815
84Abnormal hemoglobin (HP:0011902)2.02819214
85Periodontitis (HP:0000704)2.02503542
863-Methylglutaconic aciduria (HP:0003535)2.02024595
87Episodic fever (HP:0001954)2.02014656
88Leukocytosis (HP:0001974)2.01500451
89Lymphopenia (HP:0001888)2.00998371
90Entropion (HP:0000621)1.99866758
91* Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99703834
92Abnormal delayed hypersensitivity skin test (HP:0002963)1.99292245
93Thoracic kyphosis (HP:0002942)1.98847252
94Panhypogammaglobulinemia (HP:0003139)1.98227887
95Hyperammonemia (HP:0001987)1.97373773
96Chronic mucocutaneous candidiasis (HP:0002728)1.96954260
97Recurrent cutaneous fungal infections (HP:0011370)1.96954260
98Abnormality of fatty-acid metabolism (HP:0004359)1.96447689
99Basal ganglia calcification (HP:0002135)1.96359536
100Pulmonary infiltrates (HP:0002113)1.96204074
101Poikiloderma (HP:0001029)1.96104509
102Recurrent pneumonia (HP:0006532)1.95070613
103Gingivitis (HP:0000230)1.94939353
104Hypergammaglobulinemia (HP:0010702)1.94749379
105Systemic lupus erythematosus (HP:0002725)1.93061540
106Combined immunodeficiency (HP:0005387)1.91797082
107Hepatic necrosis (HP:0002605)1.91458633
108Ankle contracture (HP:0006466)1.87315164
109Severe combined immunodeficiency (HP:0004430)1.87035430
110Meningitis (HP:0001287)1.86383989
111Gastrointestinal infarctions (HP:0005244)1.86258974
112Nausea (HP:0002018)1.86067598
113Ragged-red muscle fibers (HP:0003200)1.85847939
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84770268
115Abnormality of B cell number (HP:0010975)1.84521862
116B lymphocytopenia (HP:0010976)1.84521862
117Autoimmune hemolytic anemia (HP:0001890)1.84490417
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83328344
119Selective tooth agenesis (HP:0001592)1.83235767
120Urticaria (HP:0001025)1.82183023
121Deformed sella turcica (HP:0002681)1.80833683
122Increased muscle lipid content (HP:0009058)1.80406037
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80298821
124Aplastic anemia (HP:0001915)1.80176048
125Spontaneous hematomas (HP:0007420)1.79632172
126Recurrent lower respiratory tract infections (HP:0002783)1.78830711
127Abnormality of the prostate (HP:0008775)1.78724134
128Increased serum ferritin (HP:0003281)1.78577629
129Vasculitis (HP:0002633)1.78155909
130Reduced subcutaneous adipose tissue (HP:0003758)1.78125948
131Prolonged bleeding time (HP:0003010)1.75619010
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75537886
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75537886
134Cutaneous melanoma (HP:0012056)1.75492045
135Osteomyelitis (HP:0002754)1.75461774
136Micronodular cirrhosis (HP:0001413)1.75069967
137Macrocytic anemia (HP:0001972)1.74908493
138Anorexia (HP:0002039)1.74904014
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74781259
140Dicarboxylic aciduria (HP:0003215)1.74781259
141Trismus (HP:0000211)1.74009697
142Hepatosplenomegaly (HP:0001433)1.73835576
143Abnormal platelet function (HP:0011869)1.73795255
144Impaired platelet aggregation (HP:0003540)1.73795255
145Abnormality of eosinophils (HP:0001879)1.73646963
146Progressive neurologic deterioration (HP:0002344)1.73074547
147Hepatocellular necrosis (HP:0001404)1.72915518
148Abnormality of alanine metabolism (HP:0010916)1.70818402
149Hyperalaninemia (HP:0003348)1.70818402
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70818402
151Skin rash (HP:0000988)1.68945880
152Axonal loss (HP:0003447)1.65103941
153Abnormality of the pleura (HP:0002103)1.64815231
154Hypokinesia (HP:0002375)1.63494210
155Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62202370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB12.65395095
2BLK2.64574816
3TRIB32.52394710
4MAP4K12.50053070
5NME22.39029226
6ERN12.37444427
7TBK12.37037325
8FLT32.32068671
9PIM22.29474174
10PKN22.14625930
11RIPK42.09931489
12EIF2AK12.05981699
13IRAK42.05732773
14TLK12.05600014
15TESK22.01766067
16KIT1.92296484
17WEE11.88560479
18ZAP701.83586768
19IRAK31.82086025
20TYK21.81762410
21ACVR1B1.79922931
22CDK191.79611999
23STK161.76298675
24KDR1.75282135
25ARAF1.74317753
26JAK31.72894494
27RPS6KA41.68918122
28NEK91.66311335
29IKBKE1.57104517
30BCKDK1.54680027
31LRRK21.53667802
32SCYL21.53607842
33TESK11.51085731
34TEC1.47446353
35MAP3K101.46235954
36TAOK21.40287024
37MAP3K111.39202662
38EIF2AK31.37248277
39FGFR41.36810403
40MAP3K131.35617668
41SIK31.33526973
42EEF2K1.33120727
43FES1.32078469
44BTK1.29111438
45MST1R1.27745951
46PAK41.26300431
47TGFBR21.25901277
48CSF1R1.24585027
49MAP3K11.21223890
50DYRK31.20660182
51EPHB11.16360845
52TNK21.14418897
53TGFBR11.10883581
54ILK1.09577066
55TXK1.09135058
56PIM11.07156810
57IKBKB1.06528139
58MAP2K31.04362106
59MAPKAPK31.04026167
60TAOK11.01659470
61BRSK20.97620624
62JAK10.96649938
63RPS6KB20.95037606
64STK100.94870228
65MAP4K20.94200370
66DYRK1B0.91864097
67NLK0.91238452
68ADRBK20.88900531
69VRK20.83052856
70NEK20.82394980
71SYK0.80130349
72CHUK0.78153415
73PRKD20.78009333
74MAP3K80.76536404
75LYN0.76090702
76FGFR30.75664181
77MAP3K140.74368512
78IRAK20.73923784
79IRAK10.73390990
80CDK60.73103119
81LCK0.72891506
82CDK80.72550260
83PASK0.72116403
84GRK70.72056432
85MAP2K60.69680932
86CAMKK20.68093110
87BMPR1B0.67177251
88FGR0.65691565
89MAP3K120.64829951
90GRK60.63571393
91CDK40.62307748
92ITK0.60711066
93EIF2AK20.60460048
94PRPF4B0.59759699
95PDPK10.59696014
96HCK0.58694830
97KSR20.57643141
98CSK0.56972219
99CDK90.55485050
100RPS6KA60.55402002
101VRK10.54709524
102CDK70.54643006
103ABL20.53967739
104JAK20.53822230
105RPS6KL10.53534280
106RPS6KC10.53534280
107DAPK30.51763357
108SIK20.51534900
109AURKB0.51348974
110MAP2K20.50884909
111YES10.50121915
112MAP3K50.50110579
113EPHA30.49631394
114MAP2K40.48232064
115MAPKAPK20.47974347
116MARK20.47493835
117MAPK110.46782877
118RPS6KA50.46281628
119MAP3K30.44963343
120MOS0.44025831
121MARK30.43740574
122BRAF0.43661532
123BMX0.42825172
124BMPR20.42508433
125PRKCD0.42269794
126ATR0.40856739
127PRKG20.40716824
128LIMK10.40316040
129ABL10.40202568
130MATK0.39569395
131PLK10.38966638
132MST40.38751177
133RPS6KA20.38590209
134SIK10.38082573
135TAOK30.37352524
136PDK10.36614612
137PTK60.34380116
138STK40.34257219

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.18228990
2Ribosome_Homo sapiens_hsa030103.18041924
3Proteasome_Homo sapiens_hsa030502.38204301
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17759829
5Rheumatoid arthritis_Homo sapiens_hsa053232.03096653
6Leishmaniasis_Homo sapiens_hsa051402.02843335
7Sulfur relay system_Homo sapiens_hsa041221.98642491
8Antigen processing and presentation_Homo sapiens_hsa046121.90050202
9Base excision repair_Homo sapiens_hsa034101.88378889
10Mismatch repair_Homo sapiens_hsa034301.85527467
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75477532
12Primary immunodeficiency_Homo sapiens_hsa053401.75052162
13Other glycan degradation_Homo sapiens_hsa005111.72755477
14Legionellosis_Homo sapiens_hsa051341.71470181
15Spliceosome_Homo sapiens_hsa030401.67567015
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.67522588
17Measles_Homo sapiens_hsa051621.67089832
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60683483
19Type I diabetes mellitus_Homo sapiens_hsa049401.60499230
20Lysosome_Homo sapiens_hsa041421.55292637
21RNA polymerase_Homo sapiens_hsa030201.53642769
22Oxidative phosphorylation_Homo sapiens_hsa001901.49640816
23Pentose phosphate pathway_Homo sapiens_hsa000301.47169585
24Herpes simplex infection_Homo sapiens_hsa051681.46632696
25Homologous recombination_Homo sapiens_hsa034401.43659746
26Pyrimidine metabolism_Homo sapiens_hsa002401.43462590
27Nucleotide excision repair_Homo sapiens_hsa034201.40452634
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.40050198
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37652295
30Shigellosis_Homo sapiens_hsa051311.34861340
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.33716987
32p53 signaling pathway_Homo sapiens_hsa041151.28814567
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27603475
34Folate biosynthesis_Homo sapiens_hsa007901.26157659
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25802208
36Osteoclast differentiation_Homo sapiens_hsa043801.24858216
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24699486
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.24031145
39Collecting duct acid secretion_Homo sapiens_hsa049661.22525334
40Sulfur metabolism_Homo sapiens_hsa009201.21872216
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19861110
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19318744
43Cell cycle_Homo sapiens_hsa041101.17505187
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15908277
45Protein export_Homo sapiens_hsa030601.15719572
46Malaria_Homo sapiens_hsa051441.15197329
47Pertussis_Homo sapiens_hsa051331.14304099
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12371481
49Apoptosis_Homo sapiens_hsa042101.10992917
50One carbon pool by folate_Homo sapiens_hsa006701.09310927
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09195906
52Allograft rejection_Homo sapiens_hsa053301.08810350
53B cell receptor signaling pathway_Homo sapiens_hsa046621.06070115
54RNA transport_Homo sapiens_hsa030131.03380136
55Hematopoietic cell lineage_Homo sapiens_hsa046401.03168721
56Staphylococcus aureus infection_Homo sapiens_hsa051501.03054704
57Caffeine metabolism_Homo sapiens_hsa002321.02833253
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.02803952
59Tuberculosis_Homo sapiens_hsa051521.01488130
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99350860
61Epstein-Barr virus infection_Homo sapiens_hsa051690.99317110
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98426269
63Systemic lupus erythematosus_Homo sapiens_hsa053220.97692402
64Influenza A_Homo sapiens_hsa051640.97101505
65Acute myeloid leukemia_Homo sapiens_hsa052210.94771996
66Parkinsons disease_Homo sapiens_hsa050120.94402813
67Hepatitis B_Homo sapiens_hsa051610.94166547
68Fructose and mannose metabolism_Homo sapiens_hsa000510.92388063
69N-Glycan biosynthesis_Homo sapiens_hsa005100.92058752
70Toxoplasmosis_Homo sapiens_hsa051450.91978606
71Peroxisome_Homo sapiens_hsa041460.91654987
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90742745
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90661543
74Fatty acid elongation_Homo sapiens_hsa000620.89218279
75Viral carcinogenesis_Homo sapiens_hsa052030.88160790
76Asthma_Homo sapiens_hsa053100.87866844
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87117262
78Chronic myeloid leukemia_Homo sapiens_hsa052200.86754583
79Thyroid cancer_Homo sapiens_hsa052160.85033187
80Vibrio cholerae infection_Homo sapiens_hsa051100.84954245
81Arachidonic acid metabolism_Homo sapiens_hsa005900.83223196
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82384026
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82242521
84Galactose metabolism_Homo sapiens_hsa000520.81972683
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.81758700
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80674695
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80405565
88Viral myocarditis_Homo sapiens_hsa054160.79013750
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78857573
90HTLV-I infection_Homo sapiens_hsa051660.78610062
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78580460
92Salmonella infection_Homo sapiens_hsa051320.75118361
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72583808
94TNF signaling pathway_Homo sapiens_hsa046680.70615106
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70412538
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70243799
97Small cell lung cancer_Homo sapiens_hsa052220.68930152
98Non-homologous end-joining_Homo sapiens_hsa034500.66091325
99Chemokine signaling pathway_Homo sapiens_hsa040620.64928816
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63460186
101Phagosome_Homo sapiens_hsa041450.62975201
102Renin-angiotensin system_Homo sapiens_hsa046140.62736965
103T cell receptor signaling pathway_Homo sapiens_hsa046600.62457257
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61529936
105Selenocompound metabolism_Homo sapiens_hsa004500.60090824
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.59964260
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58809609
108Graft-versus-host disease_Homo sapiens_hsa053320.56385421
109Chemical carcinogenesis_Homo sapiens_hsa052040.56350169
110Pancreatic cancer_Homo sapiens_hsa052120.56268477
111Hepatitis C_Homo sapiens_hsa051600.55924727
112Bladder cancer_Homo sapiens_hsa052190.55853410
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55338805
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53219748
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52786528
116Basal transcription factors_Homo sapiens_hsa030220.52155974
117RNA degradation_Homo sapiens_hsa030180.51259850
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51230212
119Tryptophan metabolism_Homo sapiens_hsa003800.49893350
120Purine metabolism_Homo sapiens_hsa002300.49662799
121Autoimmune thyroid disease_Homo sapiens_hsa053200.48258175
122Complement and coagulation cascades_Homo sapiens_hsa046100.47008288
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44929078
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44267115
125Metabolic pathways_Homo sapiens_hsa011000.42674183
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42266789
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.41459241
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41073320
129Carbon metabolism_Homo sapiens_hsa012000.40601747
130Glutathione metabolism_Homo sapiens_hsa004800.38477255
131Fanconi anemia pathway_Homo sapiens_hsa034600.37534011
132Alzheimers disease_Homo sapiens_hsa050100.35317673
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34824536
134Butanoate metabolism_Homo sapiens_hsa006500.33614410
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.32591069
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.30239359
137Starch and sucrose metabolism_Homo sapiens_hsa005000.30164396

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