ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transmission of nerve impulse (GO:0019226)	3.97811916
2	behavioral response to nicotine (GO:0035095)	3.87235554
3	inner mitochondrial membrane organization (GO:0007007)	3.85118676
4	ATP synthesis coupled proton transport (GO:0015986)	3.72928181
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.72928181
6	presynaptic membrane organization (GO:0097090)	3.67073143
7	thalamus development (GO:0021794)	3.67017724
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.43676387
9	parturition (GO:0007567)	3.40032916
10	negative regulation of appetite (GO:0032099)	3.39955735
11	negative regulation of response to food (GO:0032096)	3.39955735
12	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.37892171
13	substrate-independent telencephalic tangential migration (GO:0021826)	3.37892171
14	organic cation transport (GO:0015695)	3.32970654
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.32328515
16	axon ensheathment in central nervous system (GO:0032291)	3.28725601
17	central nervous system myelination (GO:0022010)	3.28725601
18	nonmotile primary cilium assembly (GO:0035058)	3.27757036
19	adult walking behavior (GO:0007628)	3.19522325
20	detection of light stimulus involved in sensory perception (GO:0050962)	3.16226457
21	detection of light stimulus involved in visual perception (GO:0050908)	3.16226457
22	photoreceptor cell maintenance (GO:0045494)	3.14464330
23	dopamine transport (GO:0015872)	3.13361947
24	regulation of chromatin binding (GO:0035561)	3.10841115
25	ribosomal small subunit assembly (GO:0000028)	3.10502329
26	neurofilament cytoskeleton organization (GO:0060052)	3.08670366
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.08293203
28	receptor recycling (GO:0001881)	3.06512029
29	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.05617971
30	axoneme assembly (GO:0035082)	3.01396598
31	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.00373451
32	potassium ion export (GO:0071435)	2.99103711
33	neuron remodeling (GO:0016322)	2.95170891
34	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.94701490
35	piRNA metabolic process (GO:0034587)	2.93968689
36	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.90769744
37	positive regulation of urine volume (GO:0035810)	2.88896160
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86532924
39	NADH dehydrogenase complex assembly (GO:0010257)	2.86532924
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86532924
41	cerebellar Purkinje cell differentiation (GO:0021702)	2.85719339
42	viral transcription (GO:0019083)	2.85484715
43	protein complex biogenesis (GO:0070271)	2.84002480
44	synaptic transmission, cholinergic (GO:0007271)	2.81356614
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.79767217
46	negative regulation of heart rate (GO:0010459)	2.77097820
47	regulation of action potential (GO:0098900)	2.76875254
48	membrane repolarization during action potential (GO:0086011)	2.76580275
49	behavioral fear response (GO:0001662)	2.75796058
50	behavioral defense response (GO:0002209)	2.75796058
51	glycerophospholipid catabolic process (GO:0046475)	2.74284320
52	energy homeostasis (GO:0097009)	2.74238707
53	startle response (GO:0001964)	2.73011639
54	behavioral response to ethanol (GO:0048149)	2.71756896
55	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71391836
56	cell differentiation in hindbrain (GO:0021533)	2.70662990
57	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.70567393
58	presynaptic membrane assembly (GO:0097105)	2.69468506
59	synaptic transmission, glutamatergic (GO:0035249)	2.69327614
60	action potential (GO:0001508)	2.68513153
61	neuron-neuron synaptic transmission (GO:0007270)	2.68382292
62	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.68138116
63	positive regulation of cAMP-mediated signaling (GO:0043950)	2.67883420
64	neuronal action potential propagation (GO:0019227)	2.67055952
65	phosphorelay signal transduction system (GO:0000160)	2.64666983
66	retina layer formation (GO:0010842)	2.63527212
67	endoderm formation (GO:0001706)	2.63017676
68	left/right axis specification (GO:0070986)	2.62857106
69	regulation of response to food (GO:0032095)	2.62143071
70	translational termination (GO:0006415)	2.61904209
71	membrane repolarization (GO:0086009)	2.60073130
72	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.59143320
73	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	2.59089966
74	regulation of membrane repolarization (GO:0060306)	2.57886815
75	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.57221048
76	epithelial cell maturation (GO:0002070)	2.57043927
77	prepulse inhibition (GO:0060134)	2.55970960
78	regulation of potassium ion transmembrane transport (GO:1901379)	2.55695579
79	fear response (GO:0042596)	2.55419177
80	cellular anion homeostasis (GO:0030002)	2.55336246
81	GTP biosynthetic process (GO:0006183)	2.55253656
82	nucleotide transmembrane transport (GO:1901679)	2.54619128
83	neuron maturation (GO:0042551)	2.54563358
84	regulation of glutamate receptor signaling pathway (GO:1900449)	2.52953580
85	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.52393823
86	gamma-aminobutyric acid transport (GO:0015812)	2.51645477
87	protein polyglutamylation (GO:0018095)	2.51436597
88	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.50906787
89	inner ear receptor stereocilium organization (GO:0060122)	2.50518963
90	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.49103158
91	respiratory electron transport chain (GO:0022904)	2.48984567
92	electron transport chain (GO:0022900)	2.48314581
93	cornea development in camera-type eye (GO:0061303)	2.47675351
94	negative regulation of adenylate cyclase activity (GO:0007194)	2.46492476
95	regulation of synapse structural plasticity (GO:0051823)	2.45536211
96	multicellular organismal signaling (GO:0035637)	2.45022874
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.44608908
98	pyrimidine nucleobase catabolic process (GO:0006208)	2.42730601
99	negative regulation of sodium ion transport (GO:0010766)	2.42589868
100	short-term memory (GO:0007614)	2.42552253

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.47406837
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.79106566
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.11127575
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.03597261
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.98411533
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.48542523
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47977307
8	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.33660483
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.32445140
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29710338
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.28303386
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.26845450
13	REST_21632747_ChIP-Seq_MESCs_Mouse	2.23257751
14	VDR_22108803_ChIP-Seq_LS180_Human	2.17404080
15	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.10787070
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08318846
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.06096662
18	FUS_26573619_Chip-Seq_HEK293_Human	2.03967131
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.01856260
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.99230769
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96635456
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96139923
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95111553
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91640406
25	P300_19829295_ChIP-Seq_ESCs_Human	1.91633524
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90296353
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.83306584
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.82831357
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.81629208
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.78765010
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.77381530
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.74923426
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.74923426
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74792991
35	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.74210223
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.68775794
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.63885812
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.63559436
39	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.63164134
40	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.62089517
41	EWS_26573619_Chip-Seq_HEK293_Human	1.60711559
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59304864
43	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.54786540
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54449892
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.50666493
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50567044
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49033323
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.48139508
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.40420582
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38976385
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36620834
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34892845
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33038982
54	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.32215372
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31992262
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31594515
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.31594515
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30303773
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30197603
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30197603
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29963378
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28639968
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27754741
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.23711789
65	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.22825524
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21708826
67	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.20526173
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19763578
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19696210
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18216566
71	JUN_21703547_ChIP-Seq_K562_Human	1.17628006
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15500012
73	TCF4_23295773_ChIP-Seq_U87_Human	1.15215770
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14917126
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14837497
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14419271
77	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.14068114
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.12454337
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11602455
80	AR_25329375_ChIP-Seq_VCAP_Human	1.10730108
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10253633
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.09875000
83	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.08611139
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08287681
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06093965
86	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06080488
87	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.05544008
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03665011
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02043195
90	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.00173994
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99490625
92	STAT3_23295773_ChIP-Seq_U87_Human	0.99312695
93	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98842055
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98749935
95	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.98603969
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98575535
97	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97935697
98	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97887755
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97205750
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94989211

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.08897955
2	MP0005423_abnormal_somatic_nervous	3.42485272
3	MP0002736_abnormal_nociception_after	2.80214625
4	MP0000372_irregular_coat_pigmentation	2.77123518
5	MP0003880_abnormal_central_pattern	2.74017009
6	MP0003787_abnormal_imprinting	2.64935710
7	MP0008004_abnormal_stomach_pH	2.49600198
8	MP0001968_abnormal_touch/_nociception	2.41028763
9	MP0002837_dystrophic_cardiac_calcinosis	2.25661992
10	MP0002638_abnormal_pupillary_reflex	2.19624199
11	MP0005646_abnormal_pituitary_gland	2.16009348
12	MP0008877_abnormal_DNA_methylation	2.14622465
13	MP0002272_abnormal_nervous_system	2.13361558
14	MP0002102_abnormal_ear_morphology	2.11965175
15	MP0001486_abnormal_startle_reflex	2.09057052
16	MP0003635_abnormal_synaptic_transmissio	2.08616052
17	MP0005551_abnormal_eye_electrophysiolog	2.07184405
18	MP0003646_muscle_fatigue	2.06946466
19	MP0004142_abnormal_muscle_tone	2.05550248
20	MP0003123_paternal_imprinting	1.99902906
21	MP0009745_abnormal_behavioral_response	1.92081115
22	MP0003136_yellow_coat_color	1.87234942
23	MP0006276_abnormal_autonomic_nervous	1.84617618
24	MP0001984_abnormal_olfaction	1.80902780
25	MP0002909_abnormal_adrenal_gland	1.75631197
26	MP0001963_abnormal_hearing_physiology	1.72268863
27	MP0009379_abnormal_foot_pigmentation	1.69278627
28	MP0002572_abnormal_emotion/affect_behav	1.67300552
29	MP0002063_abnormal_learning/memory/cond	1.67187142
30	MP0004742_abnormal_vestibular_system	1.64661349
31	MP0002064_seizures	1.64078757
32	MP0004859_abnormal_synaptic_plasticity	1.62707551
33	MP0002163_abnormal_gland_morphology	1.61638971
34	MP0008875_abnormal_xenobiotic_pharmacok	1.59075262
35	MP0002184_abnormal_innervation	1.58440985
36	MP0009046_muscle_twitch	1.56194158
37	MP0002653_abnormal_ependyma_morphology	1.56148781
38	MP0000026_abnormal_inner_ear	1.55243429
39	MP0003122_maternal_imprinting	1.54948850
40	MP0000778_abnormal_nervous_system	1.54513838
41	MP0001970_abnormal_pain_threshold	1.49410875
42	MP0004885_abnormal_endolymph	1.49176360
43	MP0002138_abnormal_hepatobiliary_system	1.48201472
44	MP0005645_abnormal_hypothalamus_physiol	1.46537847
45	MP0002067_abnormal_sensory_capabilities	1.46437695
46	MP0002557_abnormal_social/conspecific_i	1.43841896
47	MP0003121_genomic_imprinting	1.43559863
48	MP0000631_abnormal_neuroendocrine_gland	1.40916947
49	MP0002822_catalepsy	1.38178697
50	MP0002229_neurodegeneration	1.34421563
51	MP0002160_abnormal_reproductive_system	1.34177343
52	MP0004145_abnormal_muscle_electrophysio	1.33692569
53	MP0002734_abnormal_mechanical_nocicepti	1.31441665
54	MP0002733_abnormal_thermal_nociception	1.30097183
55	MP0002752_abnormal_somatic_nervous	1.29089228
56	MP0000955_abnormal_spinal_cord	1.26105547
57	MP0001440_abnormal_grooming_behavior	1.24817524
58	MP0010386_abnormal_urinary_bladder	1.24675449
59	MP0005075_abnormal_melanosome_morpholog	1.19374025
60	MP0005085_abnormal_gallbladder_physiolo	1.17204359
61	MP0005084_abnormal_gallbladder_morpholo	1.15520302
62	MP0002882_abnormal_neuron_morphology	1.12926276
63	MP0001664_abnormal_digestion	1.12616438
64	MP0002735_abnormal_chemical_nociception	1.12614793
65	MP0001188_hyperpigmentation	1.11757323
66	MP0001905_abnormal_dopamine_level	1.07926849
67	MP0005253_abnormal_eye_physiology	1.06566565
68	MP0008872_abnormal_physiological_respon	1.03837757
69	MP0008569_lethality_at_weaning	1.01366940
70	MP0001485_abnormal_pinna_reflex	1.01187452
71	MP0003252_abnormal_bile_duct	1.01145029
72	MP0005195_abnormal_posterior_eye	0.99387769
73	MP0003011_delayed_dark_adaptation	0.97876203
74	MP0004133_heterotaxia	0.88812417
75	MP0005670_abnormal_white_adipose	0.86800376
76	MP0002234_abnormal_pharynx_morphology	0.86554985
77	MP0005379_endocrine/exocrine_gland_phen	0.85080290
78	MP0002066_abnormal_motor_capabilities/c	0.84975449
79	MP0001529_abnormal_vocalization	0.84008030
80	MP0003724_increased_susceptibility_to	0.83576117
81	MP0003137_abnormal_impulse_conducting	0.80606766
82	MP0001502_abnormal_circadian_rhythm	0.77666568
83	MP0000465_gastrointestinal_hemorrhage	0.75494314
84	MP0006072_abnormal_retinal_apoptosis	0.75041039
85	MP0004924_abnormal_behavior	0.73423993
86	MP0005386_behavior/neurological_phenoty	0.73423993
87	MP0003879_abnormal_hair_cell	0.73101231
88	MP0001324_abnormal_eye_pigmentation	0.72608044
89	MP0000013_abnormal_adipose_tissue	0.72442929
90	MP0005535_abnormal_body_temperature	0.72234507
91	MP0000230_abnormal_systemic_arterial	0.71366526
92	MP0000049_abnormal_middle_ear	0.70046330
93	MP0003119_abnormal_digestive_system	0.69799709
94	MP0004484_altered_response_of	0.69768732
95	MP0003633_abnormal_nervous_system	0.69583214
96	MP0001293_anophthalmia	0.67231950
97	MP0002152_abnormal_brain_morphology	0.64187497
98	MP0005410_abnormal_fertilization	0.63931114
99	MP0002938_white_spotting	0.63917782
100	MP0004270_analgesia	0.63386862

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the corticospinal tract (HP:0002492)	4.52718235
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.42915599
3	Congenital stationary night blindness (HP:0007642)	3.97717299
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.88412959
5	Abnormality of macular pigmentation (HP:0008002)	3.75216523
6	Decreased central vision (HP:0007663)	3.73898269
7	Genetic anticipation (HP:0003743)	3.40959398
8	Acute necrotizing encephalopathy (HP:0006965)	3.30964258
9	Limb dystonia (HP:0002451)	3.17478241
10	Amyotrophic lateral sclerosis (HP:0007354)	3.16637335
11	Febrile seizures (HP:0002373)	3.15823211
12	Medial flaring of the eyebrow (HP:0010747)	3.14826491
13	Abnormality of the lower motor neuron (HP:0002366)	3.01096516
14	Myokymia (HP:0002411)	3.00566424
15	Agitation (HP:0000713)	2.96600714
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94130449
17	Growth hormone deficiency (HP:0000824)	2.90076972
18	Polyphagia (HP:0002591)	2.89402066
19	Progressive macrocephaly (HP:0004481)	2.87336301
20	Stenosis of the external auditory canal (HP:0000402)	2.83688053
21	Abnormality of the labia minora (HP:0012880)	2.72980056
22	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.72303297
23	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.72303297
24	Mitochondrial inheritance (HP:0001427)	2.71096629
25	Gait imbalance (HP:0002141)	2.69613432
26	Absent/shortened dynein arms (HP:0200106)	2.68203566
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68203566
28	Short 1st metacarpal (HP:0010034)	2.66920029
29	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.66920029
30	Optic nerve hypoplasia (HP:0000609)	2.65938725
31	Atonic seizures (HP:0010819)	2.64175031
32	Restlessness (HP:0000711)	2.61849849
33	Progressive cerebellar ataxia (HP:0002073)	2.59769571
34	Acute encephalopathy (HP:0006846)	2.58087796
35	Type II lissencephaly (HP:0007260)	2.57685475
36	Focal seizures (HP:0007359)	2.57221556
37	Attenuation of retinal blood vessels (HP:0007843)	2.56666740
38	Septo-optic dysplasia (HP:0100842)	2.56200080
39	Dyskinesia (HP:0100660)	2.51166713
40	Morphological abnormality of the pyramidal tract (HP:0002062)	2.49752542
41	Hemiparesis (HP:0001269)	2.49283779
42	Congenital primary aphakia (HP:0007707)	2.49054504
43	True hermaphroditism (HP:0010459)	2.47276215
44	Abnormal hair whorl (HP:0010721)	2.47194870
45	Molar tooth sign on MRI (HP:0002419)	2.45080488
46	Abnormality of midbrain morphology (HP:0002418)	2.45080488
47	Bony spicule pigmentary retinopathy (HP:0007737)	2.42518781
48	Pancreatic fibrosis (HP:0100732)	2.39061614
49	Abnormality of the 1st metacarpal (HP:0010009)	2.38471173
50	Nephronophthisis (HP:0000090)	2.34269876
51	Hepatoblastoma (HP:0002884)	2.33468495
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.32532756
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31738623
54	Pendular nystagmus (HP:0012043)	2.29683343
55	Pancreatic cysts (HP:0001737)	2.27962320
56	Increased CSF lactate (HP:0002490)	2.26839389
57	Hepatic necrosis (HP:0002605)	2.25258735
58	Nephrogenic diabetes insipidus (HP:0009806)	2.25170816
59	Optic disc pallor (HP:0000543)	2.24928027
60	Facial hemangioma (HP:0000329)	2.22648393
61	J-shaped sella turcica (HP:0002680)	2.21643870
62	Poor suck (HP:0002033)	2.21527221
63	Type 2 muscle fiber atrophy (HP:0003554)	2.21196681
64	Epileptic encephalopathy (HP:0200134)	2.20978787
65	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.19522339
66	Specific learning disability (HP:0001328)	2.18980585
67	Adrenal hypoplasia (HP:0000835)	2.18593584
68	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.14017051
69	Gaze-evoked nystagmus (HP:0000640)	2.13166589
70	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.11834576
71	Retinal dysplasia (HP:0007973)	2.10057933
72	Abolished electroretinogram (ERG) (HP:0000550)	2.04896283
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.03611980
74	Hepatocellular necrosis (HP:0001404)	2.03349355
75	Abnormal number of erythroid precursors (HP:0012131)	2.00563653
76	Vaginal atresia (HP:0000148)	1.97622146
77	Muscle fiber atrophy (HP:0100295)	1.95638955
78	Amblyopia (HP:0000646)	1.95343186
79	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.93564479
80	Abnormal eating behavior (HP:0100738)	1.93247335
81	Sclerocornea (HP:0000647)	1.92320854
82	Genital tract atresia (HP:0001827)	1.89278397
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88001333
84	Abnormal respiratory motile cilium physiology (HP:0012261)	1.85184101
85	Rib fusion (HP:0000902)	1.84414384
86	Conjugated hyperbilirubinemia (HP:0002908)	1.84273532
87	Abnormality of the renal medulla (HP:0100957)	1.83039876
88	Macrocytic anemia (HP:0001972)	1.82895663
89	Dialeptic seizures (HP:0011146)	1.79714682
90	Drooling (HP:0002307)	1.77554206
91	Spastic gait (HP:0002064)	1.77273906
92	Hypothermia (HP:0002045)	1.75039288
93	Absence seizures (HP:0002121)	1.74951668
94	Sleep apnea (HP:0010535)	1.74418931
95	Cerebral edema (HP:0002181)	1.72316217
96	Prolonged QT interval (HP:0001657)	1.71339933
97	Poor coordination (HP:0002370)	1.69241692
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.68160271
99	Cone-rod dystrophy (HP:0000548)	1.66807171
100	Abnormal drinking behavior (HP:0030082)	1.66749453

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	3.71470493
2	BMPR1B	2.90226941
3	NUAK1	2.88177636
4	CASK	2.70812567
5	ARAF	2.59718084
6	FRK	2.46180101
7	ADRBK2	2.42016299
8	PINK1	2.30237872
9	MAP2K7	2.02546885
10	TEC	2.00233262
11	CDK19	1.98490458
12	CAMK1D	1.93464443
13	GRK5	1.92926759
14	DYRK2	1.91006754
15	WNK3	1.88011475
16	TAF1	1.80759542
17	MAPK13	1.79198156
18	MAP4K2	1.70453790
19	MARK1	1.64618397
20	TAOK3	1.62559602
21	STK39	1.61703937
22	PIM2	1.48024967
23	CAMK1G	1.46636968
24	DMPK	1.46271911
25	OXSR1	1.45972684
26	GRK1	1.35630456
27	UHMK1	1.29805845
28	STK16	1.27779563
29	VRK2	1.26653591
30	LMTK2	1.25490106
31	DAPK2	1.23181376
32	BRAF	1.15537619
33	MAPKAPK5	1.13099523
34	PRKG2	1.06943179
35	TIE1	1.06189089
36	NTRK3	1.06036373
37	PRKCG	1.05657503
38	MAP2K4	1.05169313
39	PDK2	1.02092871
40	PRKCE	0.97894966
41	LIMK1	0.96541103
42	RIPK4	0.96095874
43	MINK1	0.94413489
44	WNK4	0.94173843
45	CSNK1G2	0.93704205
46	MUSK	0.92884714
47	CAMK2A	0.92231370
48	PLK4	0.87617596
49	CDK3	0.86123677
50	RPS6KA6	0.83789965
51	PRKCQ	0.83327558
52	RAF1	0.80561886
53	NTRK2	0.79659206
54	PHKG2	0.78002684
55	PHKG1	0.78002684
56	ADRBK1	0.77873242
57	PAK3	0.76186024
58	CSNK1G3	0.75058106
59	ZAK	0.74377136
60	MAPK15	0.69968729
61	VRK1	0.69248117
62	TYRO3	0.68060329
63	TNIK	0.66826762
64	ITK	0.66574863
65	RPS6KC1	0.65791645
66	RPS6KL1	0.65791645
67	DYRK3	0.65501498
68	BMPR2	0.65455008
69	PRKACA	0.64652521
70	ACVR1B	0.63348376
71	BCR	0.62077779
72	SYK	0.61902029
73	KDR	0.61883361
74	INSRR	0.58096579
75	PLK2	0.57461448
76	MKNK2	0.56729586
77	TXK	0.55764327
78	EPHB2	0.55756474
79	DYRK1A	0.53987142
80	CAMK1	0.53724410
81	CAMK2D	0.53548391
82	CSNK1G1	0.53488249
83	CAMK2G	0.51820574
84	EPHA4	0.51791803
85	MAPK10	0.51707528
86	CDK5	0.50922184
87	PRKG1	0.49395027
88	FES	0.47905875
89	ERBB3	0.46879271
90	CAMK2B	0.46677993
91	STK11	0.46486953
92	ABL2	0.45523826
93	RPS6KB2	0.45462630
94	CSNK1D	0.44877474
95	CSNK1A1L	0.44543141
96	RPS6KA2	0.44492004
97	PRKCA	0.43332804
98	EIF2AK2	0.42307992
99	OBSCN	0.41312985
100	CSNK1E	0.40705511

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.60632809
2	Nicotine addiction_Homo sapiens_hsa05033	3.35281182
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88481066
4	Parkinsons disease_Homo sapiens_hsa05012	2.73127696
5	Ribosome_Homo sapiens_hsa03010	2.50174990
6	Phototransduction_Homo sapiens_hsa04744	2.47956728
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.30403934
8	Olfactory transduction_Homo sapiens_hsa04740	2.15920712
9	Morphine addiction_Homo sapiens_hsa05032	2.15109049
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.12460377
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04641352
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01585995
13	beta-Alanine metabolism_Homo sapiens_hsa00410	2.00662651
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83182176
15	Caffeine metabolism_Homo sapiens_hsa00232	1.79598833
16	GABAergic synapse_Homo sapiens_hsa04727	1.77682911
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.76363864
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.71931675
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71913000
20	Long-term depression_Homo sapiens_hsa04730	1.71059874
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.69796546
22	Circadian entrainment_Homo sapiens_hsa04713	1.64631469
23	Butanoate metabolism_Homo sapiens_hsa00650	1.60771752
24	Alzheimers disease_Homo sapiens_hsa05010	1.58922529
25	Huntingtons disease_Homo sapiens_hsa05016	1.57315147
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.52111146
27	Insulin secretion_Homo sapiens_hsa04911	1.42503425
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.40847566
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.37803123
30	Salivary secretion_Homo sapiens_hsa04970	1.35065231
31	Sulfur metabolism_Homo sapiens_hsa00920	1.34864341
32	Serotonergic synapse_Homo sapiens_hsa04726	1.33670171
33	Cocaine addiction_Homo sapiens_hsa05030	1.28094088
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21119210
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20064798
36	Protein export_Homo sapiens_hsa03060	1.17761234
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.16551111
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15819759
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.14829553
40	Taste transduction_Homo sapiens_hsa04742	1.13454029
41	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.10938972
42	Renin secretion_Homo sapiens_hsa04924	1.10781620
43	Amphetamine addiction_Homo sapiens_hsa05031	1.10611878
44	Basal transcription factors_Homo sapiens_hsa03022	1.04405657
45	Gastric acid secretion_Homo sapiens_hsa04971	1.03397485
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.02007570
47	Tyrosine metabolism_Homo sapiens_hsa00350	1.01198759
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.01183044
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99221419
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95469562
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94318661
52	Gap junction_Homo sapiens_hsa04540	0.89009664
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88034300
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86485689
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.83719894
56	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.81623230
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80400668
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79854257
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76909141
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75846712
61	RNA polymerase_Homo sapiens_hsa03020	0.74482414
62	Retinol metabolism_Homo sapiens_hsa00830	0.73321306
63	Fatty acid degradation_Homo sapiens_hsa00071	0.69658142
64	Cholinergic synapse_Homo sapiens_hsa04725	0.66754937
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.65686068
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.65368029
67	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.64934354
68	Propanoate metabolism_Homo sapiens_hsa00640	0.64507118
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62753422
70	Pancreatic secretion_Homo sapiens_hsa04972	0.62614341
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58962988
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.56995573
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56538719
74	Fatty acid elongation_Homo sapiens_hsa00062	0.54737606
75	Homologous recombination_Homo sapiens_hsa03440	0.54260121
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52429505
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52328737
78	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51688761
79	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49969394
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48484806
81	Bile secretion_Homo sapiens_hsa04976	0.46718216
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46509257
83	Metabolic pathways_Homo sapiens_hsa01100	0.45912087
84	Purine metabolism_Homo sapiens_hsa00230	0.45876018
85	Peroxisome_Homo sapiens_hsa04146	0.45180943
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.43599026
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41089837
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39409851
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39151768
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38573015
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38486385
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.37910235
93	Long-term potentiation_Homo sapiens_hsa04720	0.37278111
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.36935161
95	Histidine metabolism_Homo sapiens_hsa00340	0.36910087
96	Axon guidance_Homo sapiens_hsa04360	0.36814478
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.36638041
98	Asthma_Homo sapiens_hsa05310	0.36227920
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35890140
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35066443

SPHAR

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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