SPHAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transmission of nerve impulse (GO:0019226)3.97811916
2behavioral response to nicotine (GO:0035095)3.87235554
3inner mitochondrial membrane organization (GO:0007007)3.85118676
4ATP synthesis coupled proton transport (GO:0015986)3.72928181
5energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72928181
6presynaptic membrane organization (GO:0097090)3.67073143
7thalamus development (GO:0021794)3.67017724
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43676387
9parturition (GO:0007567)3.40032916
10negative regulation of response to food (GO:0032096)3.39955735
11negative regulation of appetite (GO:0032099)3.39955735
12substrate-independent telencephalic tangential migration (GO:0021826)3.37892171
13substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.37892171
14organic cation transport (GO:0015695)3.32970654
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.32328515
16central nervous system myelination (GO:0022010)3.28725601
17axon ensheathment in central nervous system (GO:0032291)3.28725601
18nonmotile primary cilium assembly (GO:0035058)3.27757036
19adult walking behavior (GO:0007628)3.19522325
20detection of light stimulus involved in sensory perception (GO:0050962)3.16226457
21detection of light stimulus involved in visual perception (GO:0050908)3.16226457
22photoreceptor cell maintenance (GO:0045494)3.14464330
23dopamine transport (GO:0015872)3.13361947
24regulation of chromatin binding (GO:0035561)3.10841115
25ribosomal small subunit assembly (GO:0000028)3.10502329
26neurofilament cytoskeleton organization (GO:0060052)3.08670366
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08293203
28receptor recycling (GO:0001881)3.06512029
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.05617971
30axoneme assembly (GO:0035082)3.01396598
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00373451
32potassium ion export (GO:0071435)2.99103711
33neuron remodeling (GO:0016322)2.95170891
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94701490
35piRNA metabolic process (GO:0034587)2.93968689
36negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90769744
37positive regulation of urine volume (GO:0035810)2.88896160
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86532924
39mitochondrial respiratory chain complex I assembly (GO:0032981)2.86532924
40NADH dehydrogenase complex assembly (GO:0010257)2.86532924
41cerebellar Purkinje cell differentiation (GO:0021702)2.85719339
42viral transcription (GO:0019083)2.85484715
43protein complex biogenesis (GO:0070271)2.84002480
44synaptic transmission, cholinergic (GO:0007271)2.81356614
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79767217
46negative regulation of heart rate (GO:0010459)2.77097820
47regulation of action potential (GO:0098900)2.76875254
48membrane repolarization during action potential (GO:0086011)2.76580275
49behavioral defense response (GO:0002209)2.75796058
50behavioral fear response (GO:0001662)2.75796058
51glycerophospholipid catabolic process (GO:0046475)2.74284320
52energy homeostasis (GO:0097009)2.74238707
53startle response (GO:0001964)2.73011639
54behavioral response to ethanol (GO:0048149)2.71756896
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71391836
56cell differentiation in hindbrain (GO:0021533)2.70662990
57positive regulation of potassium ion transmembrane transport (GO:1901381)2.70567393
58presynaptic membrane assembly (GO:0097105)2.69468506
59synaptic transmission, glutamatergic (GO:0035249)2.69327614
60action potential (GO:0001508)2.68513153
61neuron-neuron synaptic transmission (GO:0007270)2.68382292
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68138116
63positive regulation of cAMP-mediated signaling (GO:0043950)2.67883420
64neuronal action potential propagation (GO:0019227)2.67055952
65phosphorelay signal transduction system (GO:0000160)2.64666983
66retina layer formation (GO:0010842)2.63527212
67endoderm formation (GO:0001706)2.63017676
68left/right axis specification (GO:0070986)2.62857106
69regulation of response to food (GO:0032095)2.62143071
70translational termination (GO:0006415)2.61904209
71membrane repolarization (GO:0086009)2.60073130
72regulation of potassium ion transmembrane transporter activity (GO:1901016)2.59143320
73heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.59089966
74regulation of membrane repolarization (GO:0060306)2.57886815
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57221048
76epithelial cell maturation (GO:0002070)2.57043927
77prepulse inhibition (GO:0060134)2.55970960
78regulation of potassium ion transmembrane transport (GO:1901379)2.55695579
79fear response (GO:0042596)2.55419177
80cellular anion homeostasis (GO:0030002)2.55336246
81GTP biosynthetic process (GO:0006183)2.55253656
82nucleotide transmembrane transport (GO:1901679)2.54619128
83neuron maturation (GO:0042551)2.54563358
84regulation of glutamate receptor signaling pathway (GO:1900449)2.52953580
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52393823
86gamma-aminobutyric acid transport (GO:0015812)2.51645477
87protein polyglutamylation (GO:0018095)2.51436597
88ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50906787
89inner ear receptor stereocilium organization (GO:0060122)2.50518963
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.49103158
91respiratory electron transport chain (GO:0022904)2.48984567
92electron transport chain (GO:0022900)2.48314581
93cornea development in camera-type eye (GO:0061303)2.47675351
94negative regulation of adenylate cyclase activity (GO:0007194)2.46492476
95regulation of synapse structural plasticity (GO:0051823)2.45536211
96multicellular organismal signaling (GO:0035637)2.45022874
97mitochondrial respiratory chain complex assembly (GO:0033108)2.44608908
98pyrimidine nucleobase catabolic process (GO:0006208)2.42730601
99negative regulation of sodium ion transport (GO:0010766)2.42589868
100short-term memory (GO:0007614)2.42552253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47406837
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.79106566
3GBX2_23144817_ChIP-Seq_PC3_Human3.11127575
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.03597261
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98411533
6TAF15_26573619_Chip-Seq_HEK293_Human2.48542523
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47977307
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33660483
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.32445140
10ZNF274_21170338_ChIP-Seq_K562_Hela2.29710338
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28303386
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.26845450
13REST_21632747_ChIP-Seq_MESCs_Mouse2.23257751
14VDR_22108803_ChIP-Seq_LS180_Human2.17404080
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10787070
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08318846
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06096662
18FUS_26573619_Chip-Seq_HEK293_Human2.03967131
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01856260
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99230769
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.96635456
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96139923
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95111553
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91640406
25P300_19829295_ChIP-Seq_ESCs_Human1.91633524
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.90296353
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83306584
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82831357
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81629208
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78765010
31RNF2_27304074_Chip-Seq_NSC_Mouse1.77381530
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74923426
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74923426
34IGF1R_20145208_ChIP-Seq_DFB_Human1.74792991
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74210223
36BCAT_22108803_ChIP-Seq_LS180_Human1.68775794
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63885812
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63559436
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.63164134
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62089517
41EWS_26573619_Chip-Seq_HEK293_Human1.60711559
42SMAD4_21799915_ChIP-Seq_A2780_Human1.59304864
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54786540
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.54449892
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.50666493
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.50567044
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49033323
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48139508
49ER_23166858_ChIP-Seq_MCF-7_Human1.40420582
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38976385
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36620834
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34892845
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33038982
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32215372
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31992262
56CBP_20019798_ChIP-Seq_JUKART_Human1.31594515
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31594515
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30303773
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30197603
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30197603
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29963378
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28639968
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27754741
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.23711789
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22825524
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21708826
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.20526173
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19763578
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19696210
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.18216566
71JUN_21703547_ChIP-Seq_K562_Human1.17628006
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15500012
73TCF4_23295773_ChIP-Seq_U87_Human1.15215770
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14917126
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14837497
76RUNX2_22187159_ChIP-Seq_PCA_Human1.14419271
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.14068114
78TCF4_22108803_ChIP-Seq_LS180_Human1.12454337
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.11602455
80AR_25329375_ChIP-Seq_VCAP_Human1.10730108
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10253633
82TP53_22573176_ChIP-Seq_HFKS_Human1.09875000
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08611139
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08287681
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06093965
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06080488
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.05544008
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03665011
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.02043195
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.00173994
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99490625
92STAT3_23295773_ChIP-Seq_U87_Human0.99312695
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98842055
94HTT_18923047_ChIP-ChIP_STHdh_Human0.98749935
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.98603969
96P53_22387025_ChIP-Seq_ESCs_Mouse0.98575535
97DROSHA_22980978_ChIP-Seq_HELA_Human0.97935697
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.97887755
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.97205750
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94989211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.08897955
2MP0005423_abnormal_somatic_nervous3.42485272
3MP0002736_abnormal_nociception_after2.80214625
4MP0000372_irregular_coat_pigmentation2.77123518
5MP0003880_abnormal_central_pattern2.74017009
6MP0003787_abnormal_imprinting2.64935710
7MP0008004_abnormal_stomach_pH2.49600198
8MP0001968_abnormal_touch/_nociception2.41028763
9MP0002837_dystrophic_cardiac_calcinosis2.25661992
10MP0002638_abnormal_pupillary_reflex2.19624199
11MP0005646_abnormal_pituitary_gland2.16009348
12MP0008877_abnormal_DNA_methylation2.14622465
13MP0002272_abnormal_nervous_system2.13361558
14MP0002102_abnormal_ear_morphology2.11965175
15MP0001486_abnormal_startle_reflex2.09057052
16MP0003635_abnormal_synaptic_transmissio2.08616052
17MP0005551_abnormal_eye_electrophysiolog2.07184405
18MP0003646_muscle_fatigue2.06946466
19MP0004142_abnormal_muscle_tone2.05550248
20MP0003123_paternal_imprinting1.99902906
21MP0009745_abnormal_behavioral_response1.92081115
22MP0003136_yellow_coat_color1.87234942
23MP0006276_abnormal_autonomic_nervous1.84617618
24MP0001984_abnormal_olfaction1.80902780
25MP0002909_abnormal_adrenal_gland1.75631197
26MP0001963_abnormal_hearing_physiology1.72268863
27MP0009379_abnormal_foot_pigmentation1.69278627
28MP0002572_abnormal_emotion/affect_behav1.67300552
29MP0002063_abnormal_learning/memory/cond1.67187142
30MP0004742_abnormal_vestibular_system1.64661349
31MP0002064_seizures1.64078757
32MP0004859_abnormal_synaptic_plasticity1.62707551
33MP0002163_abnormal_gland_morphology1.61638971
34MP0008875_abnormal_xenobiotic_pharmacok1.59075262
35MP0002184_abnormal_innervation1.58440985
36MP0009046_muscle_twitch1.56194158
37MP0002653_abnormal_ependyma_morphology1.56148781
38MP0000026_abnormal_inner_ear1.55243429
39MP0003122_maternal_imprinting1.54948850
40MP0000778_abnormal_nervous_system1.54513838
41MP0001970_abnormal_pain_threshold1.49410875
42MP0004885_abnormal_endolymph1.49176360
43MP0002138_abnormal_hepatobiliary_system1.48201472
44MP0005645_abnormal_hypothalamus_physiol1.46537847
45MP0002067_abnormal_sensory_capabilities1.46437695
46MP0002557_abnormal_social/conspecific_i1.43841896
47MP0003121_genomic_imprinting1.43559863
48MP0000631_abnormal_neuroendocrine_gland1.40916947
49MP0002822_catalepsy1.38178697
50MP0002229_neurodegeneration1.34421563
51MP0002160_abnormal_reproductive_system1.34177343
52MP0004145_abnormal_muscle_electrophysio1.33692569
53MP0002734_abnormal_mechanical_nocicepti1.31441665
54MP0002733_abnormal_thermal_nociception1.30097183
55MP0002752_abnormal_somatic_nervous1.29089228
56MP0000955_abnormal_spinal_cord1.26105547
57MP0001440_abnormal_grooming_behavior1.24817524
58MP0010386_abnormal_urinary_bladder1.24675449
59MP0005075_abnormal_melanosome_morpholog1.19374025
60MP0005085_abnormal_gallbladder_physiolo1.17204359
61MP0005084_abnormal_gallbladder_morpholo1.15520302
62MP0002882_abnormal_neuron_morphology1.12926276
63MP0001664_abnormal_digestion1.12616438
64MP0002735_abnormal_chemical_nociception1.12614793
65MP0001188_hyperpigmentation1.11757323
66MP0001905_abnormal_dopamine_level1.07926849
67MP0005253_abnormal_eye_physiology1.06566565
68MP0008872_abnormal_physiological_respon1.03837757
69MP0008569_lethality_at_weaning1.01366940
70MP0001485_abnormal_pinna_reflex1.01187452
71MP0003252_abnormal_bile_duct1.01145029
72MP0005195_abnormal_posterior_eye0.99387769
73MP0003011_delayed_dark_adaptation0.97876203
74MP0004133_heterotaxia0.88812417
75MP0005670_abnormal_white_adipose0.86800376
76MP0002234_abnormal_pharynx_morphology0.86554985
77MP0005379_endocrine/exocrine_gland_phen0.85080290
78MP0002066_abnormal_motor_capabilities/c0.84975449
79MP0001529_abnormal_vocalization0.84008030
80MP0003724_increased_susceptibility_to0.83576117
81MP0003137_abnormal_impulse_conducting0.80606766
82MP0001502_abnormal_circadian_rhythm0.77666568
83MP0000465_gastrointestinal_hemorrhage0.75494314
84MP0006072_abnormal_retinal_apoptosis0.75041039
85MP0004924_abnormal_behavior0.73423993
86MP0005386_behavior/neurological_phenoty0.73423993
87MP0003879_abnormal_hair_cell0.73101231
88MP0001324_abnormal_eye_pigmentation0.72608044
89MP0000013_abnormal_adipose_tissue0.72442929
90MP0005535_abnormal_body_temperature0.72234507
91MP0000230_abnormal_systemic_arterial0.71366526
92MP0000049_abnormal_middle_ear0.70046330
93MP0003119_abnormal_digestive_system0.69799709
94MP0004484_altered_response_of0.69768732
95MP0003633_abnormal_nervous_system0.69583214
96MP0001293_anophthalmia0.67231950
97MP0002152_abnormal_brain_morphology0.64187497
98MP0005410_abnormal_fertilization0.63931114
99MP0002938_white_spotting0.63917782
100MP0004270_analgesia0.63386862

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the corticospinal tract (HP:0002492)4.52718235
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.42915599
3Congenital stationary night blindness (HP:0007642)3.97717299
4Abnormal rod and cone electroretinograms (HP:0008323)3.88412959
5Abnormality of macular pigmentation (HP:0008002)3.75216523
6Decreased central vision (HP:0007663)3.73898269
7Genetic anticipation (HP:0003743)3.40959398
8Acute necrotizing encephalopathy (HP:0006965)3.30964258
9Limb dystonia (HP:0002451)3.17478241
10Amyotrophic lateral sclerosis (HP:0007354)3.16637335
11Febrile seizures (HP:0002373)3.15823211
12Medial flaring of the eyebrow (HP:0010747)3.14826491
13Abnormality of the lower motor neuron (HP:0002366)3.01096516
14Myokymia (HP:0002411)3.00566424
15Agitation (HP:0000713)2.96600714
16Abnormal mitochondria in muscle tissue (HP:0008316)2.94130449
17Growth hormone deficiency (HP:0000824)2.90076972
18Polyphagia (HP:0002591)2.89402066
19Progressive macrocephaly (HP:0004481)2.87336301
20Stenosis of the external auditory canal (HP:0000402)2.83688053
21Abnormality of the labia minora (HP:0012880)2.72980056
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.72303297
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.72303297
24Mitochondrial inheritance (HP:0001427)2.71096629
25Gait imbalance (HP:0002141)2.69613432
26Absent/shortened dynein arms (HP:0200106)2.68203566
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.68203566
28Short 1st metacarpal (HP:0010034)2.66920029
29Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.66920029
30Optic nerve hypoplasia (HP:0000609)2.65938725
31Atonic seizures (HP:0010819)2.64175031
32Restlessness (HP:0000711)2.61849849
33Progressive cerebellar ataxia (HP:0002073)2.59769571
34Acute encephalopathy (HP:0006846)2.58087796
35Type II lissencephaly (HP:0007260)2.57685475
36Focal seizures (HP:0007359)2.57221556
37Attenuation of retinal blood vessels (HP:0007843)2.56666740
38Septo-optic dysplasia (HP:0100842)2.56200080
39Dyskinesia (HP:0100660)2.51166713
40Morphological abnormality of the pyramidal tract (HP:0002062)2.49752542
41Hemiparesis (HP:0001269)2.49283779
42Congenital primary aphakia (HP:0007707)2.49054504
43True hermaphroditism (HP:0010459)2.47276215
44Abnormal hair whorl (HP:0010721)2.47194870
45Molar tooth sign on MRI (HP:0002419)2.45080488
46Abnormality of midbrain morphology (HP:0002418)2.45080488
47Bony spicule pigmentary retinopathy (HP:0007737)2.42518781
48Pancreatic fibrosis (HP:0100732)2.39061614
49Abnormality of the 1st metacarpal (HP:0010009)2.38471173
50Nephronophthisis (HP:0000090)2.34269876
51Hepatoblastoma (HP:0002884)2.33468495
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32532756
53Abnormality of cells of the erythroid lineage (HP:0012130)2.31738623
54Pendular nystagmus (HP:0012043)2.29683343
55Pancreatic cysts (HP:0001737)2.27962320
56Increased CSF lactate (HP:0002490)2.26839389
57Hepatic necrosis (HP:0002605)2.25258735
58Nephrogenic diabetes insipidus (HP:0009806)2.25170816
59Optic disc pallor (HP:0000543)2.24928027
60Facial hemangioma (HP:0000329)2.22648393
61J-shaped sella turcica (HP:0002680)2.21643870
62Poor suck (HP:0002033)2.21527221
63Type 2 muscle fiber atrophy (HP:0003554)2.21196681
64Epileptic encephalopathy (HP:0200134)2.20978787
65Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19522339
66Specific learning disability (HP:0001328)2.18980585
67Adrenal hypoplasia (HP:0000835)2.18593584
68Abnormality of the phalanges of the 5th finger (HP:0004213)2.14017051
69Gaze-evoked nystagmus (HP:0000640)2.13166589
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.11834576
71Retinal dysplasia (HP:0007973)2.10057933
72Abolished electroretinogram (ERG) (HP:0000550)2.04896283
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03611980
74Hepatocellular necrosis (HP:0001404)2.03349355
75Abnormal number of erythroid precursors (HP:0012131)2.00563653
76Vaginal atresia (HP:0000148)1.97622146
77Muscle fiber atrophy (HP:0100295)1.95638955
78Amblyopia (HP:0000646)1.95343186
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93564479
80Abnormal eating behavior (HP:0100738)1.93247335
81Sclerocornea (HP:0000647)1.92320854
82Genital tract atresia (HP:0001827)1.89278397
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88001333
84Abnormal respiratory motile cilium physiology (HP:0012261)1.85184101
85Rib fusion (HP:0000902)1.84414384
86Conjugated hyperbilirubinemia (HP:0002908)1.84273532
87Abnormality of the renal medulla (HP:0100957)1.83039876
88Macrocytic anemia (HP:0001972)1.82895663
89Dialeptic seizures (HP:0011146)1.79714682
90Drooling (HP:0002307)1.77554206
91Spastic gait (HP:0002064)1.77273906
92Hypothermia (HP:0002045)1.75039288
93Absence seizures (HP:0002121)1.74951668
94Sleep apnea (HP:0010535)1.74418931
95Cerebral edema (HP:0002181)1.72316217
96Prolonged QT interval (HP:0001657)1.71339933
97Poor coordination (HP:0002370)1.69241692
98Symphalangism affecting the phalanges of the hand (HP:0009773)1.68160271
99Cone-rod dystrophy (HP:0000548)1.66807171
100Abnormal drinking behavior (HP:0030082)1.66749453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.71470493
2BMPR1B2.90226941
3NUAK12.88177636
4CASK2.70812567
5ARAF2.59718084
6FRK2.46180101
7ADRBK22.42016299
8PINK12.30237872
9MAP2K72.02546885
10TEC2.00233262
11CDK191.98490458
12CAMK1D1.93464443
13GRK51.92926759
14DYRK21.91006754
15WNK31.88011475
16TAF11.80759542
17MAPK131.79198156
18MAP4K21.70453790
19MARK11.64618397
20TAOK31.62559602
21STK391.61703937
22PIM21.48024967
23CAMK1G1.46636968
24DMPK1.46271911
25OXSR11.45972684
26GRK11.35630456
27UHMK11.29805845
28STK161.27779563
29VRK21.26653591
30LMTK21.25490106
31DAPK21.23181376
32BRAF1.15537619
33MAPKAPK51.13099523
34PRKG21.06943179
35TIE11.06189089
36NTRK31.06036373
37PRKCG1.05657503
38MAP2K41.05169313
39PDK21.02092871
40PRKCE0.97894966
41LIMK10.96541103
42RIPK40.96095874
43MINK10.94413489
44WNK40.94173843
45CSNK1G20.93704205
46MUSK0.92884714
47CAMK2A0.92231370
48PLK40.87617596
49CDK30.86123677
50RPS6KA60.83789965
51PRKCQ0.83327558
52RAF10.80561886
53NTRK20.79659206
54PHKG20.78002684
55PHKG10.78002684
56ADRBK10.77873242
57PAK30.76186024
58CSNK1G30.75058106
59ZAK0.74377136
60MAPK150.69968729
61VRK10.69248117
62TYRO30.68060329
63TNIK0.66826762
64ITK0.66574863
65RPS6KL10.65791645
66RPS6KC10.65791645
67DYRK30.65501498
68BMPR20.65455008
69PRKACA0.64652521
70ACVR1B0.63348376
71BCR0.62077779
72SYK0.61902029
73KDR0.61883361
74INSRR0.58096579
75PLK20.57461448
76MKNK20.56729586
77TXK0.55764327
78EPHB20.55756474
79DYRK1A0.53987142
80CAMK10.53724410
81CAMK2D0.53548391
82CSNK1G10.53488249
83CAMK2G0.51820574
84EPHA40.51791803
85MAPK100.51707528
86CDK50.50922184
87PRKG10.49395027
88FES0.47905875
89ERBB30.46879271
90CAMK2B0.46677993
91STK110.46486953
92ABL20.45523826
93RPS6KB20.45462630
94CSNK1D0.44877474
95CSNK1A1L0.44543141
96RPS6KA20.44492004
97PRKCA0.43332804
98EIF2AK20.42307992
99OBSCN0.41312985
100CSNK1E0.40705511

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.60632809
2Nicotine addiction_Homo sapiens_hsa050333.35281182
3Oxidative phosphorylation_Homo sapiens_hsa001902.88481066
4Parkinsons disease_Homo sapiens_hsa050122.73127696
5Ribosome_Homo sapiens_hsa030102.50174990
6Phototransduction_Homo sapiens_hsa047442.47956728
7Cardiac muscle contraction_Homo sapiens_hsa042602.30403934
8Olfactory transduction_Homo sapiens_hsa047402.15920712
9Morphine addiction_Homo sapiens_hsa050322.15109049
10Nitrogen metabolism_Homo sapiens_hsa009102.12460377
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04641352
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.01585995
13beta-Alanine metabolism_Homo sapiens_hsa004102.00662651
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83182176
15Caffeine metabolism_Homo sapiens_hsa002321.79598833
16GABAergic synapse_Homo sapiens_hsa047271.77682911
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76363864
18Linoleic acid metabolism_Homo sapiens_hsa005911.71931675
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71913000
20Long-term depression_Homo sapiens_hsa047301.71059874
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69796546
22Circadian entrainment_Homo sapiens_hsa047131.64631469
23Butanoate metabolism_Homo sapiens_hsa006501.60771752
24Alzheimers disease_Homo sapiens_hsa050101.58922529
25Huntingtons disease_Homo sapiens_hsa050161.57315147
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52111146
27Insulin secretion_Homo sapiens_hsa049111.42503425
28Glutamatergic synapse_Homo sapiens_hsa047241.40847566
29Dopaminergic synapse_Homo sapiens_hsa047281.37803123
30Salivary secretion_Homo sapiens_hsa049701.35065231
31Sulfur metabolism_Homo sapiens_hsa009201.34864341
32Serotonergic synapse_Homo sapiens_hsa047261.33670171
33Cocaine addiction_Homo sapiens_hsa050301.28094088
34Arachidonic acid metabolism_Homo sapiens_hsa005901.21119210
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20064798
36Protein export_Homo sapiens_hsa030601.17761234
37Tryptophan metabolism_Homo sapiens_hsa003801.16551111
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15819759
39Ether lipid metabolism_Homo sapiens_hsa005651.14829553
40Taste transduction_Homo sapiens_hsa047421.13454029
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10938972
42Renin secretion_Homo sapiens_hsa049241.10781620
43Amphetamine addiction_Homo sapiens_hsa050311.10611878
44Basal transcription factors_Homo sapiens_hsa030221.04405657
45Gastric acid secretion_Homo sapiens_hsa049711.03397485
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02007570
47Tyrosine metabolism_Homo sapiens_hsa003501.01198759
48Synaptic vesicle cycle_Homo sapiens_hsa047211.01183044
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99221419
50Ovarian steroidogenesis_Homo sapiens_hsa049130.95469562
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.94318661
52Gap junction_Homo sapiens_hsa045400.89009664
53Chemical carcinogenesis_Homo sapiens_hsa052040.88034300
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86485689
55Fatty acid biosynthesis_Homo sapiens_hsa000610.83719894
56Oxytocin signaling pathway_Homo sapiens_hsa049210.81623230
57Arginine and proline metabolism_Homo sapiens_hsa003300.80400668
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79854257
59Collecting duct acid secretion_Homo sapiens_hsa049660.76909141
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75846712
61RNA polymerase_Homo sapiens_hsa030200.74482414
62Retinol metabolism_Homo sapiens_hsa008300.73321306
63Fatty acid degradation_Homo sapiens_hsa000710.69658142
64Cholinergic synapse_Homo sapiens_hsa047250.66754937
65Fatty acid metabolism_Homo sapiens_hsa012120.65686068
66cAMP signaling pathway_Homo sapiens_hsa040240.65368029
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64934354
68Propanoate metabolism_Homo sapiens_hsa006400.64507118
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62753422
70Pancreatic secretion_Homo sapiens_hsa049720.62614341
71Glycerolipid metabolism_Homo sapiens_hsa005610.58962988
72Calcium signaling pathway_Homo sapiens_hsa040200.56995573
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56538719
74Fatty acid elongation_Homo sapiens_hsa000620.54737606
75Homologous recombination_Homo sapiens_hsa034400.54260121
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.52429505
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.52328737
78Dilated cardiomyopathy_Homo sapiens_hsa054140.51688761
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49969394
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48484806
81Bile secretion_Homo sapiens_hsa049760.46718216
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46509257
83Metabolic pathways_Homo sapiens_hsa011000.45912087
84Purine metabolism_Homo sapiens_hsa002300.45876018
85Peroxisome_Homo sapiens_hsa041460.45180943
86MAPK signaling pathway_Homo sapiens_hsa040100.43599026
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.41089837
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39409851
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39151768
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38573015
91Dorso-ventral axis formation_Homo sapiens_hsa043200.38486385
92Pyruvate metabolism_Homo sapiens_hsa006200.37910235
93Long-term potentiation_Homo sapiens_hsa047200.37278111
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36935161
95Histidine metabolism_Homo sapiens_hsa003400.36910087
96Axon guidance_Homo sapiens_hsa043600.36814478
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36638041
98Asthma_Homo sapiens_hsa053100.36227920
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35890140
100Phenylalanine metabolism_Homo sapiens_hsa003600.35066443

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