SPHKAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.35227815
2regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.86103354
3regulation of actin filament-based movement (GO:1903115)6.08914264
4regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.05755060
5cell communication involved in cardiac conduction (GO:0086065)6.02189288
6cardiac muscle contraction (GO:0060048)5.95591266
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.82249960
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.69630376
9cardiac myofibril assembly (GO:0055003)5.67863363
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57498870
11sarcomere organization (GO:0045214)5.51025449
12regulation of cardiac muscle cell contraction (GO:0086004)5.40359825
13cardiac muscle hypertrophy (GO:0003300)5.10213221
14myofibril assembly (GO:0030239)5.08607753
15synaptic vesicle maturation (GO:0016188)5.07362966
16locomotory exploration behavior (GO:0035641)5.05604159
17regulation of relaxation of muscle (GO:1901077)4.98077393
18regulation of cell communication by electrical coupling (GO:0010649)4.89875713
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.85699832
20regulation of the force of heart contraction (GO:0002026)4.81218245
21striated muscle hypertrophy (GO:0014897)4.80623294
22regulation of synaptic vesicle exocytosis (GO:2000300)4.75994436
23synaptic vesicle exocytosis (GO:0016079)4.73470873
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58644404
25relaxation of cardiac muscle (GO:0055119)4.54241162
26ventricular cardiac muscle cell action potential (GO:0086005)4.43353757
27glutamate secretion (GO:0014047)4.40634999
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38468238
29cardiac chamber formation (GO:0003207)4.35208714
30vocalization behavior (GO:0071625)4.35053888
31response to pheromone (GO:0019236)4.34002534
32actin-myosin filament sliding (GO:0033275)4.31517746
33muscle filament sliding (GO:0030049)4.31517746
34neuronal action potential propagation (GO:0019227)4.27988485
35ionotropic glutamate receptor signaling pathway (GO:0035235)4.26987070
36synaptic vesicle docking involved in exocytosis (GO:0016081)4.24221166
37regulation of synaptic vesicle transport (GO:1902803)4.24033150
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.22976996
39striated muscle contraction (GO:0006941)4.22947543
40muscle hypertrophy (GO:0014896)4.22317697
41sarcoplasmic reticulum calcium ion transport (GO:0070296)4.14368383
42ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.12261750
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.10908225
44regulation of heart rate (GO:0002027)4.10713057
45synaptic transmission, glutamatergic (GO:0035249)4.08215472
46cardiac conduction (GO:0061337)4.07646674
47regulation of membrane repolarization (GO:0060306)4.06225023
48regulation of striated muscle contraction (GO:0006942)4.05699174
49neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.03255566
50cardiac muscle cell development (GO:0055013)4.01844084
51cellular potassium ion homeostasis (GO:0030007)4.01300195
52neurotransmitter secretion (GO:0007269)4.01100944
53glutamate receptor signaling pathway (GO:0007215)4.00939601
54cardiac muscle tissue morphogenesis (GO:0055008)4.00846057
55regulation of cardiac muscle contraction (GO:0055117)3.99420063
56adult heart development (GO:0007512)3.94642745
57cardiac ventricle formation (GO:0003211)3.94138287
58cardiac muscle cell action potential (GO:0086001)3.92624351
59detection of calcium ion (GO:0005513)3.92133181
60positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.90731382
61regulation of glutamate receptor signaling pathway (GO:1900449)3.83781679
62exploration behavior (GO:0035640)3.83191328
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.80887858
64cardiac muscle cell action potential involved in contraction (GO:0086002)3.79018814
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.79004324
66regulation of cardioblast differentiation (GO:0051890)3.77495696
67cerebellar Purkinje cell differentiation (GO:0021702)3.76384253
68neuron-neuron synaptic transmission (GO:0007270)3.73655564
69cardiac cell development (GO:0055006)3.73462494
70cerebellar granule cell differentiation (GO:0021707)3.72196630
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.72070417
72protein localization to synapse (GO:0035418)3.71288466
73positive regulation of synapse maturation (GO:0090129)3.69995204
74adrenergic receptor signaling pathway (GO:0071875)3.69092709
75actomyosin structure organization (GO:0031032)3.66919237
76long-term memory (GO:0007616)3.65812971
77cardiac muscle adaptation (GO:0014887)3.65462610
78cardiac muscle hypertrophy in response to stress (GO:0014898)3.65462610
79muscle hypertrophy in response to stress (GO:0003299)3.65462610
80chemosensory behavior (GO:0007635)3.64707514
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.63425141
82neuron cell-cell adhesion (GO:0007158)3.62976579
83negative regulation of potassium ion transmembrane transport (GO:1901380)3.59941010
84cellular response to epinephrine stimulus (GO:0071872)3.59416038
85gamma-aminobutyric acid transport (GO:0015812)3.59222577
86muscle tissue morphogenesis (GO:0060415)3.55736542
87actin-mediated cell contraction (GO:0070252)3.55642749
88sodium ion export (GO:0071436)3.54756656
89regulation of heart contraction (GO:0008016)3.53558703
90regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52589504
91regulation of neuronal synaptic plasticity (GO:0048168)3.52300881
92bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51744521
93innervation (GO:0060384)3.51217931
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46814690
95regulation of calcium ion transmembrane transport (GO:1903169)3.46659296
96regulation of calcium ion transmembrane transporter activity (GO:1901019)3.46659296
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44443400
98positive regulation of sodium ion transport (GO:0010765)3.43696219
99regulation of calcium ion-dependent exocytosis (GO:0017158)3.43632214
100activation of protein kinase A activity (GO:0034199)3.43059831
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42661897
102response to epinephrine (GO:0071871)3.42446491
103regulation of voltage-gated calcium channel activity (GO:1901385)3.40717336
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36122564
105cellular sodium ion homeostasis (GO:0006883)3.36099926
106layer formation in cerebral cortex (GO:0021819)3.35214972
107cell communication by electrical coupling (GO:0010644)3.34082601
108synaptic vesicle endocytosis (GO:0048488)3.33716467
109insulin secretion (GO:0030073)3.30104673
110regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28591997
111regulation of vesicle fusion (GO:0031338)3.27666792
112Golgi transport vesicle coating (GO:0048200)3.27545202
113COPI coating of Golgi vesicle (GO:0048205)3.27545202
114positive regulation of membrane potential (GO:0045838)3.27277541
115regulation of heart rate by cardiac conduction (GO:0086091)3.27046262
116neurotransmitter transport (GO:0006836)3.25939953
117protein targeting to Golgi (GO:0000042)3.24629102
118positive regulation of action potential (GO:0045760)3.22132883
119cerebellar Purkinje cell layer development (GO:0021680)3.19942470
120regulation of postsynaptic membrane potential (GO:0060078)3.19319897
121regulation of ATP catabolic process (GO:1903289)3.14041030
122regulation of ATPase activity (GO:0043462)3.14041030
123regulation of neurotransmitter secretion (GO:0046928)3.13438246
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12074130
125cell differentiation in hindbrain (GO:0021533)3.11880126
126membrane depolarization during action potential (GO:0086010)3.10930318
127dendritic spine morphogenesis (GO:0060997)3.10290857
128neurotransmitter-gated ion channel clustering (GO:0072578)3.10251883
129positive regulation of potassium ion transmembrane transport (GO:1901381)3.10184475
130positive regulation of exocytosis (GO:0045921)3.09552132
131long-term synaptic potentiation (GO:0060291)3.08073217
132presynaptic membrane organization (GO:0097090)3.07082780
133regulation of ARF protein signal transduction (GO:0032012)3.05916432
134relaxation of muscle (GO:0090075)3.05487339
135membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03176594
136multicellular organismal signaling (GO:0035637)3.00781399
137transmission of nerve impulse (GO:0019226)2.98939144
138neuromuscular process controlling posture (GO:0050884)2.98781490
139inner ear receptor cell development (GO:0060119)2.98403758
140vesicle transport along microtubule (GO:0047496)2.98200081
141positive regulation of heart rate (GO:0010460)2.97912886
142regulation of cation channel activity (GO:2001257)2.97813563
143positive regulation of cardiac muscle cell differentiation (GO:2000727)2.97346057
144potassium ion import (GO:0010107)2.96994937
145regulation of synaptic plasticity (GO:0048167)2.96221198
146neuron recognition (GO:0008038)2.95861424
147proline transport (GO:0015824)2.94206934
148establishment of protein localization to Golgi (GO:0072600)2.94097643
149regulation of sarcomere organization (GO:0060297)2.93869689
150dendrite morphogenesis (GO:0048813)2.92940156
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92875355
152regulation of neurotransmitter levels (GO:0001505)2.92206127
153long term synaptic depression (GO:0060292)2.90948787
154positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90167629
155regulation of exocytosis (GO:0017157)2.86983303
156positive regulation of vesicle fusion (GO:0031340)2.85739212
157positive regulation of cation channel activity (GO:2001259)2.85425890
158suckling behavior (GO:0001967)2.85330935
159regulation of synapse structural plasticity (GO:0051823)2.83584548
160membrane depolarization (GO:0051899)2.83189178
161regulation of sodium ion transmembrane transport (GO:1902305)2.82862161
162signal release (GO:0023061)2.82491777
163potassium ion homeostasis (GO:0055075)2.82014017
164cellular response to catecholamine stimulus (GO:0071870)2.81201987
165calcium ion-dependent exocytosis (GO:0017156)2.80987004
166neuromuscular process controlling balance (GO:0050885)2.79801427
167postsynaptic membrane organization (GO:0001941)2.79779466
168regulation of synaptic transmission, glutamatergic (GO:0051966)2.78830556
169synapse assembly (GO:0007416)2.78679601
170retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78602160
171negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78365889
172regulation of neurotransmitter transport (GO:0051588)2.78133129
173negative regulation of hormone metabolic process (GO:0032351)2.77602402
174negative regulation of hormone biosynthetic process (GO:0032353)2.77602402
175membrane repolarization (GO:0086009)2.76564199
176membrane repolarization during action potential (GO:0086011)2.75414825
177positive regulation of dendritic spine morphogenesis (GO:0061003)2.75262915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75238856
2GBX2_23144817_ChIP-Seq_PC3_Human3.44426560
3REST_21632747_ChIP-Seq_MESCs_Mouse2.92859706
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.89979031
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84056962
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81243125
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64521383
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58258925
9DROSHA_22980978_ChIP-Seq_HELA_Human2.46930001
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42853018
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37001237
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.32155660
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.31567817
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31522985
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30707692
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30707692
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27264916
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26517746
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16719137
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.14822809
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14742007
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.13439883
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11209523
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00307956
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.97644197
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.96537226
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92329837
28ZNF274_21170338_ChIP-Seq_K562_Hela1.89391836
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84366530
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.77978682
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74235208
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71570283
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70777206
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64009472
35IGF1R_20145208_ChIP-Seq_DFB_Human1.58902907
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58043230
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55903724
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55288990
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51475453
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.46417623
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.46417623
42* STAT3_23295773_ChIP-Seq_U87_Human1.46312474
43* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45056405
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41576081
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.38838532
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38386593
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36329020
48AR_19668381_ChIP-Seq_PC3_Human1.34315815
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34249289
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33983822
51* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31555942
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31325900
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30516524
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.29686888
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28803621
56* P300_19829295_ChIP-Seq_ESCs_Human1.27563750
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26905989
58AR_25329375_ChIP-Seq_VCAP_Human1.26303071
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.24991468
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24490819
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24362089
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.23483160
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22578761
64* TCF4_23295773_ChIP-Seq_U87_Human1.22291028
65VDR_22108803_ChIP-Seq_LS180_Human1.21798747
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21433164
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21052202
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20614985
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.20188389
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18340491
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.17938062
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.14499328
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14385534
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13987451
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13623210
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13373347
77TP53_16413492_ChIP-PET_HCT116_Human1.12014990
78AR_21572438_ChIP-Seq_LNCaP_Human1.12008518
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11706039
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11429454
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08933282
82TAF15_26573619_Chip-Seq_HEK293_Human1.08069060
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07543363
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.07093848
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06689416
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06435494
87* SMAD3_21741376_ChIP-Seq_ESCs_Human1.06198815
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04150442
89RUNX2_22187159_ChIP-Seq_PCA_Human1.03058522
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02906048
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02539872
92SOX9_26525672_Chip-Seq_HEART_Mouse1.00694742
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00311842
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99990574
95* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99688862
96BCAT_22108803_ChIP-Seq_LS180_Human0.99109257
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98222649
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98085655
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97965221
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97167446
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97143142
102KDM2B_26808549_Chip-Seq_K562_Human0.96692727
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96603816
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.96008658
105AHR_22903824_ChIP-Seq_MCF-7_Human0.95765519
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.94678273
107* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94071495
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.92431989
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91907136
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91715607
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.90369453
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90041744
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89739396
114RNF2_27304074_Chip-Seq_NSC_Mouse0.89109047
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89093741
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.88546798
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88302698
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87473275
119GATA1_22025678_ChIP-Seq_K562_Human0.87411119
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86964880
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.86917304
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86525966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.38380077
2MP0004084_abnormal_cardiac_muscle4.92132068
3MP0000751_myopathy4.05591937
4MP0003635_abnormal_synaptic_transmissio3.68654489
5MP0004270_analgesia3.63996174
6MP0003880_abnormal_central_pattern3.46998009
7MP0009046_muscle_twitch3.01127415
8MP0009780_abnormal_chondrocyte_physiolo3.00351488
9MP0002909_abnormal_adrenal_gland2.97345662
10MP0002063_abnormal_learning/memory/cond2.82058201
11MP0009745_abnormal_behavioral_response2.81386557
12MP0002064_seizures2.68907453
13MP0008775_abnormal_heart_ventricle2.59876395
14MP0005330_cardiomyopathy2.59513086
15MP0002972_abnormal_cardiac_muscle2.59030382
16MP0002734_abnormal_mechanical_nocicepti2.49836527
17MP0002572_abnormal_emotion/affect_behav2.49266589
18MP0002272_abnormal_nervous_system2.48000473
19MP0001968_abnormal_touch/_nociception2.39967534
20MP0004484_altered_response_of2.38928820
21MP0005423_abnormal_somatic_nervous2.21768685
22MP0003283_abnormal_digestive_organ2.20848746
23MP0000749_muscle_degeneration2.15727165
24MP0000013_abnormal_adipose_tissue2.15422388
25MP0008569_lethality_at_weaning2.09896814
26MP0002735_abnormal_chemical_nociception2.07965267
27MP0004043_abnormal_pH_regulation2.05424724
28MP0001501_abnormal_sleep_pattern2.02941930
29MP0005620_abnormal_muscle_contractility2.00496526
30MP0001486_abnormal_startle_reflex1.97894556
31MP0004145_abnormal_muscle_electrophysio1.97734787
32MP0004087_abnormal_muscle_fiber1.93484484
33MP0002067_abnormal_sensory_capabilities1.91824222
34MP0001440_abnormal_grooming_behavior1.90831804
35MP0010386_abnormal_urinary_bladder1.88342659
36MP0002733_abnormal_thermal_nociception1.87205281
37MP0005385_cardiovascular_system_phenoty1.87087867
38MP0001544_abnormal_cardiovascular_syste1.87087867
39MP0010630_abnormal_cardiac_muscle1.81601828
40MP0002736_abnormal_nociception_after1.80539589
41MP0002877_abnormal_melanocyte_morpholog1.77072934
42MP0002184_abnormal_innervation1.76704507
43MP0006072_abnormal_retinal_apoptosis1.75304597
44MP0006138_congestive_heart_failure1.73414986
45MP0001970_abnormal_pain_threshold1.72246098
46MP0003329_amyloid_beta_deposits1.68658418
47MP0002837_dystrophic_cardiac_calcinosis1.65962755
48MP0005646_abnormal_pituitary_gland1.64662668
49MP0002693_abnormal_pancreas_physiology1.63088496
50MP0003183_abnormal_peptide_metabolism1.61554202
51MP0004130_abnormal_muscle_cell1.61447466
52MP0002557_abnormal_social/conspecific_i1.60723928
53MP0002106_abnormal_muscle_physiology1.59107643
54MP0005551_abnormal_eye_electrophysiolog1.56988319
55MP0003879_abnormal_hair_cell1.56702844
56MP0004924_abnormal_behavior1.54169716
57MP0005386_behavior/neurological_phenoty1.54169716
58MP0001502_abnormal_circadian_rhythm1.50843595
59MP0001944_abnormal_pancreas_morphology1.50676129
60MP0000955_abnormal_spinal_cord1.49797795
61MP0003787_abnormal_imprinting1.49765753
62MP0004811_abnormal_neuron_physiology1.47245856
63MP0005645_abnormal_hypothalamus_physiol1.46686484
64MP0002638_abnormal_pupillary_reflex1.44416476
65MP0002127_abnormal_cardiovascular_syste1.44205634
66MP0003122_maternal_imprinting1.40626187
67MP0000747_muscle_weakness1.39949428
68MP0001984_abnormal_olfaction1.36659879
69MP0000750_abnormal_muscle_regeneration1.35280887
70MP0003646_muscle_fatigue1.35178615
71MP0005670_abnormal_white_adipose1.34304478
72MP0005379_endocrine/exocrine_gland_phen1.33295732
73MP0000778_abnormal_nervous_system1.33169258
74MP0004885_abnormal_endolymph1.31506169
75MP0002882_abnormal_neuron_morphology1.31300951
76MP0003633_abnormal_nervous_system1.30990793
77MP0004858_abnormal_nervous_system1.29761573
78MP0005369_muscle_phenotype1.29397378
79MP0002269_muscular_atrophy1.29337280
80MP0002066_abnormal_motor_capabilities/c1.29010550
81MP0002229_neurodegeneration1.21344607
82MP0002234_abnormal_pharynx_morphology1.20580565
83MP0000678_abnormal_parathyroid_gland1.16527745
84MP0006276_abnormal_autonomic_nervous1.14124920
85MP0005253_abnormal_eye_physiology1.12611044
86MP0005165_increased_susceptibility_to1.12185445
87MP0003195_calcinosis1.06982141
88MP0003172_abnormal_lysosome_physiology1.06439764
89MP0008961_abnormal_basal_metabolism1.06252070
90MP0003631_nervous_system_phenotype1.05363441
91MP0005535_abnormal_body_temperature1.02751694
92MP0002078_abnormal_glucose_homeostasis1.02690920
93MP0004142_abnormal_muscle_tone1.00496241
94MP0000631_abnormal_neuroendocrine_gland0.99585582
95MP0000759_abnormal_skeletal_muscle0.99399187
96MP0002152_abnormal_brain_morphology0.96322124
97MP0002822_catalepsy0.96222809
98MP0010368_abnormal_lymphatic_system0.95770470
99MP0001188_hyperpigmentation0.94268619
100MP0002069_abnormal_eating/drinking_beha0.93731906
101MP0001765_abnormal_ion_homeostasis0.91968224
102MP0005187_abnormal_penis_morphology0.91745850
103MP0004215_abnormal_myocardial_fiber0.90614758
104MP0001986_abnormal_taste_sensitivity0.90404196
105MP0004085_abnormal_heartbeat0.90143728
106MP0000003_abnormal_adipose_tissue0.88874030
107MP0002332_abnormal_exercise_endurance0.86700638
108MP0003632_abnormal_nervous_system0.86460637
109MP0000920_abnormal_myelination0.85934684
110MP0003690_abnormal_glial_cell0.85774100
111MP0003634_abnormal_glial_cell0.83653198
112MP0002876_abnormal_thyroid_physiology0.82685162
113MP0001299_abnormal_eye_distance/0.80566143
114MP0004233_abnormal_muscle_weight0.77810567
115MP0002090_abnormal_vision0.77472174
116MP0003953_abnormal_hormone_level0.76049902
117MP0004742_abnormal_vestibular_system0.74276728
118MP0004147_increased_porphyrin_level0.71710450
119MP0005623_abnormal_meninges_morphology0.70207648
120MP0003045_fibrosis0.69807411
121MP0001348_abnormal_lacrimal_gland0.68833488
122MP0001963_abnormal_hearing_physiology0.68776192
123MP0005409_darkened_coat_color0.68284543
124MP0000569_abnormal_digit_pigmentation0.66385552
125MP0000266_abnormal_heart_morphology0.66244788
126MP0002752_abnormal_somatic_nervous0.64588216
127MP0004510_myositis0.64190987
128MP0003123_paternal_imprinting0.63968013
129MP0004036_abnormal_muscle_relaxation0.63885422
130MP0003567_abnormal_fetal_cardiomyocyte0.63272649
131MP0003279_aneurysm0.61788751
132MP0000604_amyloidosis0.61008706
133MP0001905_abnormal_dopamine_level0.60906537
134MP0001529_abnormal_vocalization0.59573215
135MP0006292_abnormal_olfactory_placode0.59256495
136MP0003137_abnormal_impulse_conducting0.56604295
137MP0002896_abnormal_bone_mineralization0.55374366
138MP0003828_pulmonary_edema0.54290539

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.62058060
2Atrial fibrillation (HP:0005110)6.74598343
3Syncope (HP:0001279)6.57833045
4Ventricular tachycardia (HP:0004756)6.25630632
5Primary atrial arrhythmia (HP:0001692)6.19621815
6Focal motor seizures (HP:0011153)5.96200867
7Supraventricular tachycardia (HP:0004755)5.95718617
8Supraventricular arrhythmia (HP:0005115)5.80144907
9Visual hallucinations (HP:0002367)5.63577837
10Heart block (HP:0012722)5.12363461
11Right ventricular cardiomyopathy (HP:0011663)5.04199338
12Ventricular arrhythmia (HP:0004308)4.84743772
13Lipoatrophy (HP:0100578)4.79553531
14Abnormal atrioventricular conduction (HP:0005150)4.77516797
15Hyporeflexia of lower limbs (HP:0002600)4.72829314
16Abnormality of the calf musculature (HP:0001430)4.50930041
17Focal seizures (HP:0007359)4.47464595
18Progressive cerebellar ataxia (HP:0002073)4.36797050
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.28406147
20Epileptic encephalopathy (HP:0200134)4.28335677
21Action tremor (HP:0002345)4.22361282
22Atonic seizures (HP:0010819)4.18794112
23Myokymia (HP:0002411)4.13096014
24Muscle fiber splitting (HP:0003555)4.08068858
25Dilated cardiomyopathy (HP:0001644)3.97446424
26Subaortic stenosis (HP:0001682)3.94580166
27Abnormality of the left ventricular outflow tract (HP:0011103)3.94580166
28Prolonged QT interval (HP:0001657)3.93434401
29Atrioventricular block (HP:0001678)3.92978907
30Absence seizures (HP:0002121)3.80971414
31Hyperinsulinemic hypoglycemia (HP:0000825)3.78048222
32Febrile seizures (HP:0002373)3.68809729
33Abnormal EKG (HP:0003115)3.66024326
34Asymmetric septal hypertrophy (HP:0001670)3.54529107
35Impaired smooth pursuit (HP:0007772)3.43480546
36Gaze-evoked nystagmus (HP:0000640)3.41709729
37EMG: neuropathic changes (HP:0003445)3.41530992
38Dialeptic seizures (HP:0011146)3.40130562
39Calf muscle hypertrophy (HP:0008981)3.31829499
40Truncal ataxia (HP:0002078)3.27083135
41Left ventricular hypertrophy (HP:0001712)3.25713825
42Agitation (HP:0000713)3.24221872
43Epileptiform EEG discharges (HP:0011182)3.22523030
44Generalized tonic-clonic seizures (HP:0002069)3.21792007
45EMG: myopathic abnormalities (HP:0003458)3.18765048
46EEG with generalized epileptiform discharges (HP:0011198)3.16717084
47Palpitations (HP:0001962)3.13721454
48Depression (HP:0000716)3.02328058
49Dysdiadochokinesis (HP:0002075)3.00939731
50Hypsarrhythmia (HP:0002521)2.99628096
51Hemiparesis (HP:0001269)2.99097030
52Papilledema (HP:0001085)2.98309944
53Abnormality of ocular smooth pursuit (HP:0000617)2.97776783
54Hypoglycemic seizures (HP:0002173)2.97637552
55Supranuclear gaze palsy (HP:0000605)2.97603647
56Decreased circulating renin level (HP:0003351)2.97182521
57Broad-based gait (HP:0002136)2.94387192
58Muscle hypertrophy of the lower extremities (HP:0008968)2.86044154
59Anxiety (HP:0000739)2.77483715
60Poor eye contact (HP:0000817)2.71560161
61Abnormality of calcium-phosphate metabolism (HP:0100530)2.71353956
62Dysmetria (HP:0001310)2.69683969
63Symptomatic seizures (HP:0011145)2.68536092
64Genetic anticipation (HP:0003743)2.68405142
65Diplopia (HP:0000651)2.64623742
66Abnormality of binocular vision (HP:0011514)2.64623742
67Scanning speech (HP:0002168)2.64433924
68Hyperventilation (HP:0002883)2.60440424
69Abnormality of the lower motor neuron (HP:0002366)2.60121271
70Intention tremor (HP:0002080)2.56507484
71Excessive salivation (HP:0003781)2.55888327
72Drooling (HP:0002307)2.55888327
73Distal lower limb muscle weakness (HP:0009053)2.54285656
74Insulin-resistant diabetes mellitus (HP:0000831)2.52201907
75Abnormality of the foot musculature (HP:0001436)2.51418755
76Pheochromocytoma (HP:0002666)2.49506760
77Bradycardia (HP:0001662)2.48499929
78Abnormal social behavior (HP:0012433)2.47344232
79Impaired social interactions (HP:0000735)2.47344232
80Dysmetric saccades (HP:0000641)2.43313934
81Cerebral inclusion bodies (HP:0100314)2.39665913
82Congenital malformation of the right heart (HP:0011723)2.37617293
83Double outlet right ventricle (HP:0001719)2.37617293
84Hemiplegia (HP:0002301)2.36019613
85Sudden cardiac death (HP:0001645)2.35542165
86Neurofibrillary tangles (HP:0002185)2.30895049
87Increased circulating renin level (HP:0000848)2.30469363
88Postural tremor (HP:0002174)2.30120582
89Hypoplastic left heart (HP:0004383)2.26111041
90Amblyopia (HP:0000646)2.24238097
91Ragged-red muscle fibers (HP:0003200)2.23960747
92Ankle clonus (HP:0011448)2.23472868
93Pancreatic islet-cell hyperplasia (HP:0004510)2.22759934
94Ventricular fibrillation (HP:0001663)2.21580316
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.18839915
96Hyperglycemia (HP:0003074)2.18501786
97Postural instability (HP:0002172)2.17102053
98Impaired vibration sensation in the lower limbs (HP:0002166)2.17069400
99Abnormality of the pancreatic islet cells (HP:0006476)2.16695855
100Abnormality of endocrine pancreas physiology (HP:0012093)2.16695855
101Ketoacidosis (HP:0001993)2.16519296
102Amyotrophic lateral sclerosis (HP:0007354)2.14184560
103Central scotoma (HP:0000603)2.13760051
104Foot dorsiflexor weakness (HP:0009027)2.13481517
105Large for gestational age (HP:0001520)2.13210250
106Steppage gait (HP:0003376)2.12351276
107Spastic gait (HP:0002064)2.08418881
108Neuroendocrine neoplasm (HP:0100634)2.07043533
109Abnormal eating behavior (HP:0100738)2.06827016
110Gait ataxia (HP:0002066)2.04836665
111Megalencephaly (HP:0001355)2.03778679
112Limb ataxia (HP:0002070)2.03575943
113Neck muscle weakness (HP:0000467)2.01743633
114Bradykinesia (HP:0002067)2.01737052
115Palmoplantar keratoderma (HP:0000982)2.01120914
116Retinal atrophy (HP:0001105)1.99706139
117Menstrual irregularities (HP:0000858)1.98293219
118Type 1 muscle fiber predominance (HP:0003803)1.97630803
119Bundle branch block (HP:0011710)1.97214779
120Abnormality of renin-angiotensin system (HP:0000847)1.93692371
121Urinary bladder sphincter dysfunction (HP:0002839)1.93318974
122Absent speech (HP:0001344)1.92938059
123Abnormality of macular pigmentation (HP:0008002)1.91781988
124Restlessness (HP:0000711)1.90531848
125Hypoplastic heart (HP:0001961)1.88783187
126Blue irides (HP:0000635)1.87697506
127Mutism (HP:0002300)1.87462383
128Stereotypic behavior (HP:0000733)1.86693747
129Macroorchidism (HP:0000053)1.85715872
130Psychosis (HP:0000709)1.84995741
131Difficulty running (HP:0009046)1.83359675
132Areflexia of lower limbs (HP:0002522)1.83284650
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82703261
134Obstructive sleep apnea (HP:0002870)1.82176627
135Type II lissencephaly (HP:0007260)1.82051129
136Status epilepticus (HP:0002133)1.80842509
137Tetraplegia (HP:0002445)1.79698091
138Gait imbalance (HP:0002141)1.78342392
139Myotonia (HP:0002486)1.77108046
140Neoplasm of the heart (HP:0100544)1.76021833
141Neuronal loss in central nervous system (HP:0002529)1.75557138
142Hypoglycemic coma (HP:0001325)1.74826770
143Rimmed vacuoles (HP:0003805)1.74256679
144Mildly elevated creatine phosphokinase (HP:0008180)1.73571049
145Abnormality of the corticospinal tract (HP:0002492)1.73363962
146Hyperkalemia (HP:0002153)1.72407074
147Global brain atrophy (HP:0002283)1.71684103
148Clonus (HP:0002169)1.71636478
149Resting tremor (HP:0002322)1.71313649
150Anomalous pulmonary venous return (HP:0010772)1.71022512
151Lower limb muscle weakness (HP:0007340)1.70458342
152Limb dystonia (HP:0002451)1.69943722
153Failure to thrive in infancy (HP:0001531)1.69898617
154Slow progression (HP:0003677)1.69884845
155Hypokalemia (HP:0002900)1.69482469
156Periauricular skin pits (HP:0100277)1.68148405
157Preauricular pit (HP:0004467)1.68148405
158Lymphangioma (HP:0100764)1.68050739
159Congestive heart failure (HP:0001635)1.62128934
160Lower limb amyotrophy (HP:0007210)1.56725650
161Hip contracture (HP:0003273)1.54273822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.64033325
2OBSCN3.69199863
3MYLK3.69002963
4DMPK3.34868213
5MAP3K93.00545841
6INSRR2.96001945
7PRKD32.85578169
8MAP3K42.82844850
9MARK12.79702171
10CAMKK22.57656948
11EPHA42.51508535
12MINK12.25186808
13TTN2.22998921
14MAP2K72.22598965
15MAP3K22.05927720
16CAMKK12.00544303
17DAPK21.94221104
18PAK61.84935767
19NTRK11.82869596
20MAP2K41.70119817
21PNCK1.66287376
22UHMK11.63285021
23NTRK21.63068366
24KSR21.62916859
25RIPK41.60424998
26PKN21.58306727
27CASK1.51737675
28WNK31.51192943
29STK381.47225065
30MAPK151.46442970
31MAPK121.45857829
32WNK11.39892662
33GRK71.39680859
34CDK51.38990112
35GRK51.38193650
36PRPF4B1.36224231
37PIK3CA1.35968506
38HIPK21.32793960
39PRKCG1.27634386
40LMTK21.25584228
41PRKCH1.23133003
42RIPK11.19614006
43SCYL21.16416670
44DAPK11.16057364
45CDC42BPA1.15896282
46KSR11.14539926
47FRK1.14328137
48TAOK31.13992461
49PLK21.13830601
50LATS21.13479261
51PRKD11.12048371
52ROCK11.07321278
53PASK1.07041630
54MAP3K11.06346241
55STK38L1.05716079
56MAPK131.05387496
57SGK4941.02870342
58SGK2231.02870342
59WNK41.00585611
60CAMK2B1.00229287
61MUSK0.98789800
62CAMK2A0.97931297
63RET0.97336601
64TNIK0.96732372
65ROCK20.95897284
66LIMK10.94961879
67DYRK1A0.94575412
68SGK20.93648335
69SIK20.91355136
70PAK30.88219104
71BMPR20.88170542
72AKT30.85865844
73PINK10.85440551
74PKN10.85433930
75CAMK2D0.84238681
76MAP3K120.83996186
77MAP3K70.82980130
78CAMK10.82631074
79FES0.80196853
80STK110.80065524
81CDK190.77739604
82SGK30.75681164
83CAMK1G0.75205692
84SGK10.72822105
85MAP3K50.72324236
86PHKG10.71858434
87PHKG20.71858434
88MARK20.71735278
89FER0.71529173
90TRPM70.69080492
91ARAF0.66590177
92PRKCE0.64916665
93CDK150.64727465
94PDK20.64253152
95CDK180.64230141
96CDK140.63473555
97ALK0.62382591
98PDK10.59981062
99PTK2B0.58905013
100MAPK70.58571756
101TYRO30.57344894
102PTK20.57321438
103PDGFRA0.56550782
104RPS6KA30.54729986
105CDK11A0.53852525
106PDPK10.52432687
107FGFR20.51102956
108PRKD20.50945132
109CAMK2G0.48780932
110MAP3K130.47489841
111MAPK40.46640209
112MAPK100.46446013
113PRKAA10.45998979
114DAPK30.45389375
115NEK60.45038463
116MAP3K60.43393106
117LATS10.43153123
118DDR20.42888647
119PRKG10.42813306
120CSNK1G20.42652785
121PRKACA0.41830350
122PRKAA20.39776088
123NEK90.39406619
124FYN0.38969477
125STK40.38606025
126PRKCZ0.38448313
127OXSR10.38194425
128PRKCB0.38014974
129PRKCA0.37573085
130CAMK40.37332346
131RPS6KB10.36289837
132PRKACG0.36208771
133MAP2K10.35856349

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36946377
2Insulin secretion_Homo sapiens_hsa049112.90886420
3Synaptic vesicle cycle_Homo sapiens_hsa047212.82526827
4Long-term potentiation_Homo sapiens_hsa047202.79489296
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.78747508
6Circadian entrainment_Homo sapiens_hsa047132.64865370
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60999804
8GABAergic synapse_Homo sapiens_hsa047272.53891143
9Glutamatergic synapse_Homo sapiens_hsa047242.47755779
10Amphetamine addiction_Homo sapiens_hsa050312.47015025
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34744067
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28633125
13Morphine addiction_Homo sapiens_hsa050322.24319636
14Taste transduction_Homo sapiens_hsa047422.12498930
15Dopaminergic synapse_Homo sapiens_hsa047282.06928161
16Type II diabetes mellitus_Homo sapiens_hsa049302.03343796
17Salivary secretion_Homo sapiens_hsa049701.95944834
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93323579
19Olfactory transduction_Homo sapiens_hsa047401.89814627
20Cholinergic synapse_Homo sapiens_hsa047251.79801040
21Long-term depression_Homo sapiens_hsa047301.79235347
22Gastric acid secretion_Homo sapiens_hsa049711.65563471
23Cocaine addiction_Homo sapiens_hsa050301.60439675
24Renin secretion_Homo sapiens_hsa049241.58682379
25Serotonergic synapse_Homo sapiens_hsa047261.57643385
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52227655
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46366761
28Oxytocin signaling pathway_Homo sapiens_hsa049211.42931525
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42337836
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.38903160
31Calcium signaling pathway_Homo sapiens_hsa040201.38685185
32Pancreatic secretion_Homo sapiens_hsa049721.37545762
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37226680
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35819313
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33386652
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31947168
37Phototransduction_Homo sapiens_hsa047441.27914010
38Estrogen signaling pathway_Homo sapiens_hsa049151.27259347
39Collecting duct acid secretion_Homo sapiens_hsa049661.25765339
40GnRH signaling pathway_Homo sapiens_hsa049121.23526050
41cAMP signaling pathway_Homo sapiens_hsa040241.21974489
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19290845
43Vibrio cholerae infection_Homo sapiens_hsa051101.19210788
44Thyroid hormone synthesis_Homo sapiens_hsa049181.14125163
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13962788
46Gap junction_Homo sapiens_hsa045401.13514938
47Type I diabetes mellitus_Homo sapiens_hsa049401.12248324
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06367094
49Circadian rhythm_Homo sapiens_hsa047101.04747141
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.00864793
51Glucagon signaling pathway_Homo sapiens_hsa049220.96211193
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88459658
53Melanogenesis_Homo sapiens_hsa049160.87453015
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84824828
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83124324
56Dorso-ventral axis formation_Homo sapiens_hsa043200.82606790
57Glioma_Homo sapiens_hsa052140.82262978
58Cardiac muscle contraction_Homo sapiens_hsa042600.81123009
59Inositol phosphate metabolism_Homo sapiens_hsa005620.74959650
60Tight junction_Homo sapiens_hsa045300.74405069
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72515549
62Oocyte meiosis_Homo sapiens_hsa041140.70488214
63ErbB signaling pathway_Homo sapiens_hsa040120.69378323
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68358090
65mTOR signaling pathway_Homo sapiens_hsa041500.66886085
66Dilated cardiomyopathy_Homo sapiens_hsa054140.66128605
67Protein export_Homo sapiens_hsa030600.64617497
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.64007214
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63910969
70PPAR signaling pathway_Homo sapiens_hsa033200.63415639
71Axon guidance_Homo sapiens_hsa043600.61115300
72Arginine biosynthesis_Homo sapiens_hsa002200.58806574
73Choline metabolism in cancer_Homo sapiens_hsa052310.56901857
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56778641
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56329187
76MAPK signaling pathway_Homo sapiens_hsa040100.55658970
77Propanoate metabolism_Homo sapiens_hsa006400.54629241
78Focal adhesion_Homo sapiens_hsa045100.54586231
79AMPK signaling pathway_Homo sapiens_hsa041520.50583893
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50326108
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49581912
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.49273642
83Sulfur metabolism_Homo sapiens_hsa009200.47537276
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47236144
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46985937
86Alcoholism_Homo sapiens_hsa050340.46763167
87Prion diseases_Homo sapiens_hsa050200.46645052
88Bile secretion_Homo sapiens_hsa049760.45552657
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44698463
90Adherens junction_Homo sapiens_hsa045200.43638834
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43500946
92ECM-receptor interaction_Homo sapiens_hsa045120.43458418
93Insulin signaling pathway_Homo sapiens_hsa049100.43265401
94Arginine and proline metabolism_Homo sapiens_hsa003300.42578402
95VEGF signaling pathway_Homo sapiens_hsa043700.42028005
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39413174
97Prolactin signaling pathway_Homo sapiens_hsa049170.39280213
98Protein digestion and absorption_Homo sapiens_hsa049740.38966444
99Phenylalanine metabolism_Homo sapiens_hsa003600.37964867
100Ras signaling pathway_Homo sapiens_hsa040140.37766196
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34669884
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34659673
103Ovarian steroidogenesis_Homo sapiens_hsa049130.34082992
104Butanoate metabolism_Homo sapiens_hsa006500.33298820
105Endometrial cancer_Homo sapiens_hsa052130.33055090
106Wnt signaling pathway_Homo sapiens_hsa043100.32986428
107Insulin resistance_Homo sapiens_hsa049310.32946464
108N-Glycan biosynthesis_Homo sapiens_hsa005100.32839911
109Parkinsons disease_Homo sapiens_hsa050120.32836034
110Endocytosis_Homo sapiens_hsa041440.32545505
111Carbon metabolism_Homo sapiens_hsa012000.31765681
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.31348632
113Amoebiasis_Homo sapiens_hsa051460.30590767
114Lysosome_Homo sapiens_hsa041420.30261757
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29440800
116Renal cell carcinoma_Homo sapiens_hsa052110.29113485
117Alzheimers disease_Homo sapiens_hsa050100.29076658
118Fatty acid metabolism_Homo sapiens_hsa012120.28855717
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28347204
120Pyruvate metabolism_Homo sapiens_hsa006200.27327095
121Nitrogen metabolism_Homo sapiens_hsa009100.27292252
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27253492
123Rap1 signaling pathway_Homo sapiens_hsa040150.27051744
124Mineral absorption_Homo sapiens_hsa049780.26819240

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »