SPIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.73867760
2positive regulation of gamma-delta T cell activation (GO:0046645)8.77756437
3positive regulation of B cell differentiation (GO:0045579)7.20328348
4regulation of gamma-delta T cell differentiation (GO:0045586)6.44938018
5regulation of B cell differentiation (GO:0045577)6.34127296
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.22015326
7regulation of gamma-delta T cell activation (GO:0046643)6.07264509
8serine transport (GO:0032329)5.92864702
9antigen processing and presentation of endogenous antigen (GO:0019883)5.81210038
10regulation of superoxide anion generation (GO:0032928)5.51739503
11L-serine transport (GO:0015825)5.49272367
12regulation of B cell receptor signaling pathway (GO:0050855)5.15269620
13immunoglobulin mediated immune response (GO:0016064)5.13882831
14cellular response to zinc ion (GO:0071294)5.11812546
15B cell proliferation (GO:0042100)4.99255608
16neutrophil activation involved in immune response (GO:0002283)4.95044934
17regulation of histone H3-K9 methylation (GO:0051570)4.86003087
18neutrophil activation (GO:0042119)4.84822665
19V(D)J recombination (GO:0033151)4.73419467
20regulation of antigen processing and presentation (GO:0002577)4.73158699
21positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.72951293
22regulation of platelet aggregation (GO:0090330)4.66728429
23positive regulation of mast cell activation involved in immune response (GO:0033008)4.41831562
24positive regulation of mast cell degranulation (GO:0043306)4.41831562
25negative regulation of histone methylation (GO:0031061)4.28467067
26granulocyte activation (GO:0036230)4.28123472
27lymph vessel development (GO:0001945)4.24022983
28negative regulation of phagocytosis (GO:0050765)4.23585532
29regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.21558940
30positive regulation by symbiont of host defense response (GO:0052509)4.17653025
31modulation by symbiont of host defense response (GO:0052031)4.17653025
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17653025
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17653025
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.17653025
35modulation by symbiont of host immune response (GO:0052553)4.17653025
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16137817
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16137817
38B cell mediated immunity (GO:0019724)4.14609642
39antigen receptor-mediated signaling pathway (GO:0050851)4.13059417
40macrophage activation involved in immune response (GO:0002281)4.11141817
41regulation of alpha-beta T cell proliferation (GO:0046640)4.05902729
42regulation of dendritic cell antigen processing and presentation (GO:0002604)4.03700099
43positive regulation of antigen processing and presentation (GO:0002579)4.03112307
44regulation of B cell proliferation (GO:0030888)4.02940463
45regulation of interferon-gamma biosynthetic process (GO:0045072)4.01558949
46T cell homeostasis (GO:0043029)3.99172954
47mature B cell differentiation (GO:0002335)3.98739976
48positive regulation of interferon-alpha production (GO:0032727)3.93630507
49negative regulation of B cell proliferation (GO:0030889)3.89573364
50lymphocyte homeostasis (GO:0002260)3.87710106
51positive thymic T cell selection (GO:0045059)3.87699229
52positive regulation of cell adhesion mediated by integrin (GO:0033630)3.84963034
53regulation of interferon-alpha production (GO:0032647)3.75731907
54negative regulation of bone resorption (GO:0045779)3.71545006
55hepatocyte apoptotic process (GO:0097284)3.70882155
56negative thymic T cell selection (GO:0045060)3.70715561
57response to type I interferon (GO:0034340)3.69410689
58natural killer cell differentiation (GO:0001779)3.68777729
59regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.65777705
60B cell homeostasis (GO:0001782)3.65521773
61T cell selection (GO:0045058)3.64942042
62cellular response to type I interferon (GO:0071357)3.63965071
63type I interferon signaling pathway (GO:0060337)3.63965071
64B cell activation (GO:0042113)3.61323785
65positive regulation of B cell activation (GO:0050871)3.60755144
66regulation of B cell apoptotic process (GO:0002902)3.57913275
67NIK/NF-kappaB signaling (GO:0038061)3.56899942
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56117060
69negative regulation of cell killing (GO:0031342)3.56117060
70positive regulation of mast cell activation (GO:0033005)3.55009832
71tachykinin receptor signaling pathway (GO:0007217)3.50910345
72immune response-activating cell surface receptor signaling pathway (GO:0002429)3.49975675
73B cell differentiation (GO:0030183)3.49490105
74negative T cell selection (GO:0043383)3.49111435
75germinal center formation (GO:0002467)3.47726743
76positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.47323154
77positive regulation of B cell proliferation (GO:0030890)3.46052360
78vesicle targeting (GO:0006903)3.45162944
79tolerance induction (GO:0002507)3.44836251
80negative regulation of telomere maintenance (GO:0032205)3.44739247
81detection of bacterium (GO:0016045)3.43903135
82regulation of interferon-beta biosynthetic process (GO:0045357)3.43661487
83CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40425879
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40363838
85positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38869804
86positive T cell selection (GO:0043368)3.37029585
87regulation of superoxide metabolic process (GO:0090322)3.36635536
88leukocyte homeostasis (GO:0001776)3.34841083
89Peyers patch development (GO:0048541)3.34755478
90mucosal-associated lymphoid tissue development (GO:0048537)3.34755478
91defense response to protozoan (GO:0042832)3.33692010
92positive regulation of interferon-beta production (GO:0032728)3.30039144
93regulation of B cell activation (GO:0050864)3.28206632
94positive regulation of gene expression, epigenetic (GO:0045815)3.27617521
95regulation of interferon-beta production (GO:0032648)3.25597049
96regulation of interleukin-12 biosynthetic process (GO:0045075)3.23766143
97behavioral response to nicotine (GO:0035095)3.23176760
98thymic T cell selection (GO:0045061)3.21772421
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19664120
100regulation of germinal center formation (GO:0002634)3.19629509
101mononuclear cell proliferation (GO:0032943)3.18660916
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17363057
103T cell costimulation (GO:0031295)3.16629608
104regulation of mast cell degranulation (GO:0043304)3.16615189
105lymphocyte proliferation (GO:0046651)3.16196118
106positive regulation of bone remodeling (GO:0046852)3.15637950
107positive regulation of bone resorption (GO:0045780)3.15637950
108positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.15536131
109interferon-gamma-mediated signaling pathway (GO:0060333)3.14782572
110Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.14320929
111immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.14320929
112Fc-gamma receptor signaling pathway (GO:0038094)3.14320929
113positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13743883
114positive regulation of protein homooligomerization (GO:0032464)3.13639538
115DNA deamination (GO:0045006)3.13273609
116lymphocyte costimulation (GO:0031294)3.13157089
117cellular response to interleukin-15 (GO:0071350)3.11368408
118lymph node development (GO:0048535)3.09751641
119Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.09624185
120production of molecular mediator involved in inflammatory response (GO:0002532)3.09004570
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07562922
122response to protozoan (GO:0001562)3.07227547
123negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.06736674
124positive regulation of leukocyte degranulation (GO:0043302)3.06332190
125pyrimidine ribonucleoside catabolic process (GO:0046133)3.06252714
126detection of other organism (GO:0098543)3.03916580
127response to interleukin-15 (GO:0070672)3.01667661
128positive regulation of defense response to virus by host (GO:0002230)3.00051719
129adaptation of signaling pathway (GO:0023058)2.99856092
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98256739
131positive regulation by host of viral transcription (GO:0043923)2.97155260
132negative regulation of bone remodeling (GO:0046851)2.96064371
133regulation of T cell mediated cytotoxicity (GO:0001914)2.96019577
134positive regulation of histone deacetylation (GO:0031065)2.94188291
135fucose catabolic process (GO:0019317)2.93979645
136L-fucose metabolic process (GO:0042354)2.93979645
137L-fucose catabolic process (GO:0042355)2.93979645
138positive regulation of alpha-beta T cell differentiation (GO:0046638)2.92154729
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91998472
140response to host immune response (GO:0052572)2.91998472
141myeloid dendritic cell activation (GO:0001773)2.91276795
142respiratory burst (GO:0045730)2.91142046
143mature B cell differentiation involved in immune response (GO:0002313)2.91131855
144positive regulation of interferon-gamma production (GO:0032729)2.89833716
145cellular response to interferon-gamma (GO:0071346)2.88025694
146cytidine deamination (GO:0009972)2.87143191
147cytidine metabolic process (GO:0046087)2.87143191
148cytidine catabolic process (GO:0006216)2.87143191
149regulation of mast cell activation involved in immune response (GO:0033006)2.86720170
150activation of JUN kinase activity (GO:0007257)2.86618387
151positive regulation of interleukin-12 production (GO:0032735)2.85887426
152I-kappaB phosphorylation (GO:0007252)2.84392411
153regulation of MHC class I biosynthetic process (GO:0045343)2.82502275
154T-helper 1 type immune response (GO:0042088)2.81755010
155microglial cell activation (GO:0001774)2.75800873
156cellular response to interferon-beta (GO:0035458)2.74810739
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71057638
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.67894373
159purinergic nucleotide receptor signaling pathway (GO:0035590)2.65576890
160T cell migration (GO:0072678)2.64829351
161adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.62553012
162cellular response to exogenous dsRNA (GO:0071360)2.61214679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.67398934
2E2F7_22180533_ChIP-Seq_HELA_Human5.36566874
3* MYC_22102868_ChIP-Seq_BL_Human5.17205134
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.81476238
5* SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.52481145
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.52281199
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16476044
8* VDR_21846776_ChIP-Seq_THP-1_Human3.76061199
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.75105271
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60760743
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.37102768
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23983152
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.20137866
14ZNF274_21170338_ChIP-Seq_K562_Hela3.13726713
15RUNX_20019798_ChIP-Seq_JUKART_Human3.13721436
16IRF8_27001747_Chip-Seq_BMDM_Mouse3.05743894
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.81312037
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.74781521
19MYB_26560356_Chip-Seq_TH2_Human2.65164109
20MAF_26560356_Chip-Seq_TH1_Human2.61606938
21MYB_26560356_Chip-Seq_TH1_Human2.57653766
22VDR_24763502_ChIP-Seq_THP-1_Human2.52041509
23UTX_26944678_Chip-Seq_JUKART_Human2.50407624
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34566343
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34068484
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24592990
27SCL_19346495_ChIP-Seq_HPC-7_Human2.19416483
28TCF7_22412390_ChIP-Seq_EML_Mouse2.18177240
29CIITA_25753668_ChIP-Seq_RAJI_Human2.17395429
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11717851
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11641879
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04057620
33IRF1_19129219_ChIP-ChIP_H3396_Human2.00282424
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99653640
35SPI1_23547873_ChIP-Seq_NB4_Human1.96161001
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96094377
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94624500
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88241845
39KDM2B_26808549_Chip-Seq_DND41_Human1.82199321
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.75959806
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74521093
42SPI1_23127762_ChIP-Seq_K562_Human1.72671305
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71615610
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70928824
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70079332
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.69103489
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.60631877
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58180192
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56709440
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54668587
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52165943
52* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52001588
53GATA1_22025678_ChIP-Seq_K562_Human1.50803639
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47967657
55MAF_26560356_Chip-Seq_TH2_Human1.45031834
56* BCL6_27268052_Chip-Seq_Bcells_Human1.44802043
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44524248
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.42704267
59GATA3_27048872_Chip-Seq_THYMUS_Human1.42227271
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41705015
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38967990
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35425161
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35400060
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32107350
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.31868598
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31830409
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28405409
68BCOR_27268052_Chip-Seq_Bcells_Human1.27691475
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26909821
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26739364
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26289952
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21606577
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20792517
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20401159
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19536866
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19005043
77VDR_22108803_ChIP-Seq_LS180_Human1.18968835
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18395309
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17558978
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17532779
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.17478069
82NANOG_20526341_ChIP-Seq_ESCs_Human1.17027227
83PU_27001747_Chip-Seq_BMDM_Mouse1.15802598
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15668321
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14657680
86TAF2_19829295_ChIP-Seq_ESCs_Human1.10323224
87TP53_22573176_ChIP-Seq_HFKS_Human1.09062358
88VDR_24787735_ChIP-Seq_THP-1_Human1.07680198
89IGF1R_20145208_ChIP-Seq_DFB_Human1.07185022
90ERA_21632823_ChIP-Seq_H3396_Human1.06446111
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06431328
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05497101
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05033603
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.05033603
95* E2F1_20622854_ChIP-Seq_HELA_Human1.04631412
96MYC_18940864_ChIP-ChIP_HL60_Human1.04493059
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.04075094
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02727541
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02353362
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02261117
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01704960
102SMRT_27268052_Chip-Seq_Bcells_Human1.01453943
103RAC3_21632823_ChIP-Seq_H3396_Human1.00604715
104ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99675508
105* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.98937095
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98667720
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98220924
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97720754
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.97407675
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97197628
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.97135872
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96559646
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95942581
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.95292643
115* ELF1_20517297_ChIP-Seq_JURKAT_Human0.94345939
116GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93590860
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93466012
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92592819
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92239166
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.91551984
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91266724
122BCAT_22108803_ChIP-Seq_LS180_Human0.91021217
123* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90647323
124EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90639224
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90170188
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90067139
127MYC_19829295_ChIP-Seq_ESCs_Human0.90023338
128NCOR1_26117541_ChIP-Seq_K562_Human0.89474704
129SPI1_20517297_ChIP-Seq_HL60_Human0.88377825
130CEBPB_22108803_ChIP-Seq_LS180_Human0.87415529
131DROSHA_22980978_ChIP-Seq_HELA_Human0.87153074
132NCOR_22424771_ChIP-Seq_293T_Human0.86816229
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.86022198
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.84849994
135FOXP3_21729870_ChIP-Seq_TREG_Human0.82376367
136GATA3_26560356_Chip-Seq_TH2_Human0.82110529
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79273214
138ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77551430
139* P300_27268052_Chip-Seq_Bcells_Human0.76138773
140EZH2_22144423_ChIP-Seq_EOC_Human0.75897677
141GATA3_26560356_Chip-Seq_TH1_Human0.74761291
142SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74707736
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71784784
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70161400
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65445564
146VDR_23849224_ChIP-Seq_CD4+_Human0.64667583
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.64317299
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.64159220
149KDM5A_27292631_Chip-Seq_BREAST_Human0.63977211
150RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63496522
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.61574813
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.61108140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.28494344
2MP0001790_abnormal_immune_system4.89601029
3MP0005387_immune_system_phenotype4.89601029
4* MP0001800_abnormal_humoral_immune4.82585879
5MP0000685_abnormal_immune_system4.36990767
6* MP0002452_abnormal_antigen_presenting3.66371109
7MP0003303_peritoneal_inflammation3.56670739
8MP0005000_abnormal_immune_tolerance3.09933857
9* MP0002723_abnormal_immune_serum2.99645107
10* MP0002420_abnormal_adaptive_immunity2.97102702
11* MP0002398_abnormal_bone_marrow2.95506914
12* MP0001819_abnormal_immune_cell2.89249990
13MP0005671_abnormal_response_to2.87064756
14* MP0000716_abnormal_immune_system2.69078251
15* MP0000689_abnormal_spleen_morphology2.59642552
16MP0002166_altered_tumor_susceptibility2.44141705
17MP0006054_spinal_hemorrhage2.43159587
18MP0002396_abnormal_hematopoietic_system2.36577514
19MP0002722_abnormal_immune_system2.32955479
20* MP0002429_abnormal_blood_cell2.17435658
21MP0003763_abnormal_thymus_physiology2.09633170
22MP0009785_altered_susceptibility_to2.05681170
23MP0005025_abnormal_response_to2.03036400
24MP0003300_gastrointestinal_ulcer1.98842788
25MP0003436_decreased_susceptibility_to1.98837459
26MP0001873_stomach_inflammation1.98610410
27MP0000703_abnormal_thymus_morphology1.96024806
28MP0004808_abnormal_hematopoietic_stem1.92125422
29MP0003724_increased_susceptibility_to1.83665185
30MP0002148_abnormal_hypersensitivity_rea1.80701421
31MP0010155_abnormal_intestine_physiology1.77342585
32MP0002419_abnormal_innate_immunity1.72967230
33MP0002405_respiratory_system_inflammati1.68782729
34MP0002006_tumorigenesis1.68199223
35MP0001879_abnormal_lymphatic_vessel1.66100916
36MP0008057_abnormal_DNA_replication1.61697859
37MP0005310_abnormal_salivary_gland1.61130731
38MP0001845_abnormal_inflammatory_respons1.57107268
39MP0008872_abnormal_physiological_respon1.49732134
40MP0004947_skin_inflammation1.45985824
41MP0004510_myositis1.41779307
42MP0003866_abnormal_defecation1.37197029
43MP0002933_joint_inflammation1.33836247
44MP0000372_irregular_coat_pigmentation1.33190015
45MP0000465_gastrointestinal_hemorrhage1.30398006
46MP0005075_abnormal_melanosome_morpholog1.29562035
47MP0002254_reproductive_system_inflammat1.28409474
48MP0001853_heart_inflammation1.27196704
49MP0010094_abnormal_chromosome_stability1.26165553
50MP0003787_abnormal_imprinting1.26080011
51MP0003183_abnormal_peptide_metabolism1.25031097
52MP0002019_abnormal_tumor_incidence1.22653629
53MP0009278_abnormal_bone_marrow1.19756679
54MP0001348_abnormal_lacrimal_gland1.19053670
55MP0002163_abnormal_gland_morphology1.16077190
56MP0002638_abnormal_pupillary_reflex1.11932582
57MP0003252_abnormal_bile_duct1.09489303
58MP0003646_muscle_fatigue1.06684049
59MP0010234_abnormal_vibrissa_follicle1.01889692
60MP0005464_abnormal_platelet_physiology1.01699339
61MP0003077_abnormal_cell_cycle0.98135934
62MP0002138_abnormal_hepatobiliary_system0.97953204
63MP0002009_preneoplasia0.96881633
64MP0004142_abnormal_muscle_tone0.96347554
65MP0005551_abnormal_eye_electrophysiolog0.96141497
66MP0002095_abnormal_skin_pigmentation0.95297994
67MP0002136_abnormal_kidney_physiology0.93494253
68MP0000490_abnormal_crypts_of0.91685548
69MP0009333_abnormal_splenocyte_physiolog0.89462324
70MP0010352_gastrointestinal_tract_polyps0.87498763
71MP0003091_abnormal_cell_migration0.86529393
72MP0005076_abnormal_cell_differentiation0.85337927
73MP0003195_calcinosis0.83035678
74MP0004742_abnormal_vestibular_system0.81936618
75MP0002653_abnormal_ependyma_morphology0.80425817
76MP0009046_muscle_twitch0.79813789
77MP0009764_decreased_sensitivity_to0.79306241
78MP0002132_abnormal_respiratory_system0.78034714
79MP0008469_abnormal_protein_level0.71616718
80MP0005084_abnormal_gallbladder_morpholo0.71588190
81MP0001986_abnormal_taste_sensitivity0.71251181
82MP0004043_abnormal_pH_regulation0.71170841
83MP0001968_abnormal_touch/_nociception0.71148937
84MP0005381_digestive/alimentary_phenotyp0.70024139
85MP0001485_abnormal_pinna_reflex0.69506478
86MP0002876_abnormal_thyroid_physiology0.68526116
87MP0001663_abnormal_digestive_system0.68262951
88MP0002928_abnormal_bile_duct0.68109537
89MP0003111_abnormal_nucleus_morphology0.67572549
90MP0005397_hematopoietic_system_phenotyp0.67563567
91MP0001545_abnormal_hematopoietic_system0.67563567
92MP0000350_abnormal_cell_proliferation0.67207117
93MP0003453_abnormal_keratinocyte_physiol0.66454299
94MP0008874_decreased_physiological_sensi0.66061923
95MP0005645_abnormal_hypothalamus_physiol0.65614806
96MP0003045_fibrosis0.64619070
97MP0006082_CNS_inflammation0.64456107
98MP0002102_abnormal_ear_morphology0.63943331
99MP0000015_abnormal_ear_pigmentation0.63533744
100MP0005379_endocrine/exocrine_gland_phen0.63446584
101MP0004145_abnormal_muscle_electrophysio0.62368052
102MP0001764_abnormal_homeostasis0.60943071
103MP0005174_abnormal_tail_pigmentation0.60604213
104MP0009745_abnormal_behavioral_response0.60346888
105MP0005621_abnormal_cell_physiology0.59970292
106MP0008877_abnormal_DNA_methylation0.58121248
107MP0001533_abnormal_skeleton_physiology0.57445490
108MP0004381_abnormal_hair_follicle0.56069742
109MP0009931_abnormal_skin_appearance0.56025990
110MP0002693_abnormal_pancreas_physiology0.55636624
111MP0000470_abnormal_stomach_morphology0.55467343
112MP0000313_abnormal_cell_death0.54254722
113MP0002735_abnormal_chemical_nociception0.54197656
114MP0008058_abnormal_DNA_repair0.53590762
115MP0003279_aneurysm0.51729244
116MP0008961_abnormal_basal_metabolism0.51518772
117MP0005085_abnormal_gallbladder_physiolo0.51155547
118MP0000631_abnormal_neuroendocrine_gland0.50995151
119MP0009643_abnormal_urine_homeostasis0.50833515
120MP0002083_premature_death0.50297261
121MP0002139_abnormal_hepatobiliary_system0.50188209
122MP0005501_abnormal_skin_physiology0.49299600
123MP0002909_abnormal_adrenal_gland0.49016210
124MP0003693_abnormal_embryo_hatching0.48507783
125MP0002277_abnormal_respiratory_mucosa0.48497788
126MP0000767_abnormal_smooth_muscle0.47259235
127MP0000249_abnormal_blood_vessel0.47086002
128MP0001784_abnormal_fluid_regulation0.46715595
129MP0010386_abnormal_urinary_bladder0.46635264
130MP0003566_abnormal_cell_adhesion0.45856318
131MP0003943_abnormal_hepatobiliary_system0.42860938
132MP0001919_abnormal_reproductive_system0.41418428
133MP0001915_intracranial_hemorrhage0.40854449
134MP0005451_abnormal_body_composition0.40150135
135MP0000569_abnormal_digit_pigmentation0.39927289

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.91045508
2Cellulitis (HP:0100658)7.08800566
3Papilloma (HP:0012740)6.92222043
4Verrucae (HP:0200043)6.92222043
5Gastrointestinal stroma tumor (HP:0100723)6.33437045
6Recurrent bronchitis (HP:0002837)6.16588275
7Abnormality of B cell number (HP:0010975)5.84872215
8B lymphocytopenia (HP:0010976)5.84872215
9Recurrent sinusitis (HP:0011108)5.69459670
10Colitis (HP:0002583)5.63976855
11Small epiphyses (HP:0010585)5.38967283
12Panhypogammaglobulinemia (HP:0003139)5.22506719
13Recurrent viral infections (HP:0004429)5.16597410
14Thyroiditis (HP:0100646)5.03179106
15Meningitis (HP:0001287)5.00950633
16Inflammation of the large intestine (HP:0002037)4.80270691
17Chronic sinusitis (HP:0011109)4.66892165
18Gastrointestinal inflammation (HP:0004386)4.63812570
19Osteomyelitis (HP:0002754)4.32128660
20IgM deficiency (HP:0002850)4.20854826
21Recurrent pneumonia (HP:0006532)4.15331402
22Lymphopenia (HP:0001888)4.08691301
23Sepsis (HP:0100806)3.96518606
24Vertebral arch anomaly (HP:0008438)3.91284797
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.90681913
26Abnormality of cells of the lymphoid lineage (HP:0012140)3.90329640
27Mitral stenosis (HP:0001718)3.78866045
28Recurrent lower respiratory tract infections (HP:0002783)3.76310800
29Emphysema (HP:0002097)3.74945748
30Recurrent otitis media (HP:0000403)3.73559806
31Recurrent fungal infections (HP:0002841)3.68514623
32Bronchitis (HP:0012387)3.53864244
33Abnormality of the intervertebral disk (HP:0005108)3.44290817
34Hypoplasia of the capital femoral epiphysis (HP:0003090)3.39711469
35Flattened epiphyses (HP:0003071)3.38572232
36Vasculitis (HP:0002633)3.35900433
37Congenital stationary night blindness (HP:0007642)3.26291563
38IgG deficiency (HP:0004315)3.19947656
39Chronic otitis media (HP:0000389)3.17881780
40Chronic mucocutaneous candidiasis (HP:0002728)3.11383055
41Recurrent cutaneous fungal infections (HP:0011370)3.11383055
42Severe combined immunodeficiency (HP:0004430)3.07759159
43Restrictive lung disease (HP:0002091)3.06210565
44T lymphocytopenia (HP:0005403)2.90012631
45Combined immunodeficiency (HP:0005387)2.89584117
46Abnormality of the fingertips (HP:0001211)2.86562292
47Arthropathy (HP:0003040)2.82045728
48Abnormality of T cell number (HP:0011839)2.80532899
49Ulnar bowing (HP:0003031)2.75847781
50IgA deficiency (HP:0002720)2.75246777
51Hypoplasia of the thymus (HP:0000778)2.71505449
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.69407041
53Absent epiphyses (HP:0010577)2.69407041
54Recurrent bacterial skin infections (HP:0005406)2.63114776
55Recurrent abscess formation (HP:0002722)2.62651899
56Irregular vertebral endplates (HP:0003301)2.60674741
57Skin rash (HP:0000988)2.57146622
58Abnormality of T cells (HP:0002843)2.55557643
59Stomatitis (HP:0010280)2.54342429
60Eosinophilia (HP:0001880)2.52558890
61Lymphoma (HP:0002665)2.52500709
62Mediastinal lymphadenopathy (HP:0100721)2.52487932
63Recurrent skin infections (HP:0001581)2.38699772
64Pulmonary infiltrates (HP:0002113)2.33896946
65Abnormality of the prostate (HP:0008775)2.32393204
66Leukopenia (HP:0001882)2.31671302
67Pancreatic cysts (HP:0001737)2.30862517
68Viral hepatitis (HP:0006562)2.28181021
69Neutropenia (HP:0001875)2.25729248
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20824299
71Abnormality of T cell physiology (HP:0011840)2.19720536
72Barrel-shaped chest (HP:0001552)2.19372177
73Limited elbow extension (HP:0001377)2.15866774
74Skin ulcer (HP:0200042)2.14444850
75Granulocytopenia (HP:0001913)2.14073600
76Abnormality of midbrain morphology (HP:0002418)2.12640696
77Molar tooth sign on MRI (HP:0002419)2.12640696
78Elevated erythrocyte sedimentation rate (HP:0003565)2.11593405
79Increased IgE level (HP:0003212)2.07451971
80Abnormality of eosinophils (HP:0001879)2.07409672
81Urticaria (HP:0001025)2.04746404
82Attenuation of retinal blood vessels (HP:0007843)2.04599335
83Retrobulbar optic neuritis (HP:0100654)2.04178762
84Optic neuritis (HP:0100653)2.04178762
85Stomach cancer (HP:0012126)2.02297086
86Eczematoid dermatitis (HP:0000976)2.01880914
87Obstructive lung disease (HP:0006536)1.99676500
88Chronic obstructive pulmonary disease (HP:0006510)1.99676500
89Abnormality of the vertebral endplates (HP:0005106)1.98250402
90Increased IgM level (HP:0003496)1.98163590
91Progressive inability to walk (HP:0002505)1.95287300
92Encephalitis (HP:0002383)1.94397887
93Vertebral clefting (HP:0008428)1.92575167
94Dehydration (HP:0001944)1.91643329
95Visual hallucinations (HP:0002367)1.89600839
96Hypoproteinemia (HP:0003075)1.86455340
97Abnormal rod and cone electroretinograms (HP:0008323)1.85163854
98Spontaneous hematomas (HP:0007420)1.84997226
993-Methylglutaconic aciduria (HP:0003535)1.84576328
100Decreased circulating renin level (HP:0003351)1.83252991
101Abnormality of the pleura (HP:0002103)1.82313621
102Keratoconjunctivitis (HP:0001096)1.82224819
103Bronchiectasis (HP:0002110)1.82095595
104Aortic regurgitation (HP:0001659)1.81761331
105Nephronophthisis (HP:0000090)1.79591803
106Interstitial pulmonary disease (HP:0006530)1.78052930
107Hemoptysis (HP:0002105)1.77792785
108Bile duct proliferation (HP:0001408)1.77443643
109Abnormal biliary tract physiology (HP:0012439)1.77443643
110Chronic diarrhea (HP:0002028)1.75757269
111Chronic hepatic failure (HP:0100626)1.75053719
112Long eyelashes (HP:0000527)1.73735649
113Pustule (HP:0200039)1.73252497
114Abnormality of macrophages (HP:0004311)1.71560536
115Facial diplegia (HP:0001349)1.71263781
116Global brain atrophy (HP:0002283)1.70820737
117Myositis (HP:0100614)1.70567895
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.69439427
119Methylmalonic aciduria (HP:0012120)1.69399587
120Recurrent gram-negative bacterial infections (HP:0005420)1.68254513
121Volvulus (HP:0002580)1.67253739
122Hypoplasia of the pons (HP:0012110)1.66938196
123Aqueductal stenosis (HP:0002410)1.66721907
124Abnormality of the renal cortex (HP:0011035)1.66679194
125Orchitis (HP:0100796)1.65755416
126Gastrointestinal infarctions (HP:0005244)1.65515346
127Autoimmune thrombocytopenia (HP:0001973)1.64600871
128Chest pain (HP:0100749)1.64303138
129Villous atrophy (HP:0011473)1.63682995
130Abnormality of small intestinal villus morphology (HP:0011472)1.63682995
131Abnormality of the pons (HP:0007361)1.63622506
132Hematochezia (HP:0002573)1.63350422
133Hypochromic anemia (HP:0001931)1.63272917
134Acute lymphatic leukemia (HP:0006721)1.63035292
135Thrombocytosis (HP:0001894)1.62695339
136External ear malformation (HP:0008572)1.61677549
137True hermaphroditism (HP:0010459)1.61478392
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.61464031
139Pancreatic fibrosis (HP:0100732)1.61067914
140Focal motor seizures (HP:0011153)1.61020938
141Abnormality of male internal genitalia (HP:0000022)1.60607728
142Short femoral neck (HP:0100864)1.60518161
143Nasal polyposis (HP:0100582)1.57832481
144Abnormality of carpal bone ossification (HP:0006257)1.57438869
145Leukocytosis (HP:0001974)1.56427393
146Arthralgia (HP:0002829)1.54618514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K107.57551110
2MAP4K15.08200160
3GRK64.31123705
4ERN13.19435396
5BLK3.13125407
6SYK2.66870276
7RIPK42.64132009
8BTK2.38987604
9CSF1R2.34871425
10ACVR1B2.19580423
11ADRBK22.13291971
12MAP3K142.05589604
13SIK21.99326329
14STK101.90639257
15TAOK31.84371355
16EEF2K1.84016984
17TXK1.69724768
18LYN1.69445025
19BMPR1B1.63882327
20LRRK21.59020871
21CDK121.55205216
22CLK11.38991057
23MAP3K131.38760821
24TLK11.37870929
25FRK1.37207861
26STK41.35241747
27TYK21.34551297
28NUAK11.32133392
29VRK21.29692283
30CSK1.26876105
31HCK1.25785889
32VRK11.22096533
33JAK11.19756413
34CDK191.19706767
35PIM11.17889711
36FES1.17073929
37TAF11.17057273
38DYRK1B1.15023572
39CDK41.14925996
40CDK91.13980399
41SIK31.11576644
42EIF2AK31.11463334
43MST41.11299403
44TNK21.10858402
45MARK31.07046756
46GRK11.05217420
47INSRR1.02910117
48IKBKB1.00962879
49NEK20.99343277
50WNK30.98142245
51TBK10.97493006
52PASK0.97261345
53LCK0.96182600
54FGFR30.95539781
55MAP2K20.94932019
56MAPK70.94448167
57OXSR10.94414256
58IRAK40.93363683
59WNK10.92996353
60BRD40.92929168
61ITK0.88300255
62DYRK30.86034770
63HIPK20.83208055
64TEC0.81857197
65MAP4K20.81440798
66ADRBK10.81301548
67MATK0.80280100
68PRKD20.79465302
69PRKCQ0.75013983
70MAPK40.74815961
71MAP3K110.73014596
72ZAP700.71971791
73RPS6KB20.71267687
74TRIB30.70445554
75IRAK30.69105337
76MELK0.68972955
77PRKD10.68721781
78JAK30.68195710
79NEK90.67698407
80FGFR20.67471750
81MAPK120.65292030
82MAP3K70.63243190
83CHUK0.62587309
84PRKCI0.61823865
85DAPK20.61811064
86NLK0.59824714
87IRAK10.59672725
88IKBKE0.55935901
89CDC42BPA0.55693135
90SIK10.55494868
91KIT0.53087066
92FYN0.52456565
93PKN10.51902239
94DYRK20.51140542
95TGFBR20.49873932
96INSR0.48283537
97MAPK110.47015741
98PRKCZ0.44866886
99ABL10.44651587
100MAP2K60.42496376
101SMG10.42387517
102SGK30.42129920
103TGFBR10.42002552
104JAK20.39632877
105CDK30.38384435
106ALK0.37347576
107DYRK1A0.37309879
108MAPKAPK30.37113034
109MAP3K80.36855864
110RPS6KA40.36786946
111BMPR20.36394645
112CHEK10.35838512
113MAPKAPK20.35686373
114FGFR40.35513452
115STK240.34660415
116CDK60.34344746
117PRKCH0.34313115
118KDR0.33716474
119ZAK0.32890980
120MARK20.32684402
121MAPKAPK50.32581809
122PDK10.31058680
123PKN20.30827683
124WNK40.29492005
125PTK60.28854780
126RPS6KA50.28679491
127MKNK20.28626657
128STK110.27453942
129EGFR0.26670462
130FGR0.26524586
131MAPK130.26466394
132PRKCD0.26277648
133PINK10.25844997
134BCKDK0.25736628
135YES10.24998597
136RPS6KB10.24476696
137CSNK1A10.22349906

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.30998818
2B cell receptor signaling pathway_Homo sapiens_hsa046625.98686272
3Asthma_Homo sapiens_hsa053104.49661333
4Autoimmune thyroid disease_Homo sapiens_hsa053204.28383025
5Graft-versus-host disease_Homo sapiens_hsa053324.11845491
6Type I diabetes mellitus_Homo sapiens_hsa049403.62332021
7Non-homologous end-joining_Homo sapiens_hsa034503.06805442
8NF-kappa B signaling pathway_Homo sapiens_hsa040643.04573361
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.76273025
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.38027271
11Hematopoietic cell lineage_Homo sapiens_hsa046402.35678676
12Staphylococcus aureus infection_Homo sapiens_hsa051502.23684284
13Osteoclast differentiation_Homo sapiens_hsa043802.16314091
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11894304
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.01041379
16Antigen processing and presentation_Homo sapiens_hsa046121.87646629
17Base excision repair_Homo sapiens_hsa034101.67772266
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65419111
19Leishmaniasis_Homo sapiens_hsa051401.65147686
20Systemic lupus erythematosus_Homo sapiens_hsa053221.58299535
21T cell receptor signaling pathway_Homo sapiens_hsa046601.47623439
22Non-small cell lung cancer_Homo sapiens_hsa052231.43771044
23Chemokine signaling pathway_Homo sapiens_hsa040621.43686705
24Measles_Homo sapiens_hsa051621.39132228
25Epstein-Barr virus infection_Homo sapiens_hsa051691.36423891
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33271974
27Herpes simplex infection_Homo sapiens_hsa051681.33121640
28Tuberculosis_Homo sapiens_hsa051521.31630186
29Rheumatoid arthritis_Homo sapiens_hsa053231.30198609
30Viral carcinogenesis_Homo sapiens_hsa052031.29285079
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28003276
32Phototransduction_Homo sapiens_hsa047441.25263558
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22460344
34Chronic myeloid leukemia_Homo sapiens_hsa052201.21564292
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17356548
36Linoleic acid metabolism_Homo sapiens_hsa005911.14106830
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13891629
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.10770203
39Hepatitis B_Homo sapiens_hsa051611.10209749
40Mismatch repair_Homo sapiens_hsa034301.09894758
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09371167
42Pancreatic cancer_Homo sapiens_hsa052121.09299286
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08843684
44Platelet activation_Homo sapiens_hsa046111.04155648
45Toxoplasmosis_Homo sapiens_hsa051450.99819310
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.95361338
47Influenza A_Homo sapiens_hsa051640.95317018
48Apoptosis_Homo sapiens_hsa042100.94848491
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92646601
50Alcoholism_Homo sapiens_hsa050340.91891842
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88924255
52Acute myeloid leukemia_Homo sapiens_hsa052210.86706015
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86348356
54HTLV-I infection_Homo sapiens_hsa051660.86300765
55Shigellosis_Homo sapiens_hsa051310.86278344
56Ether lipid metabolism_Homo sapiens_hsa005650.86069250
57Small cell lung cancer_Homo sapiens_hsa052220.85315607
58Selenocompound metabolism_Homo sapiens_hsa004500.85276134
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84865152
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.84197552
61FoxO signaling pathway_Homo sapiens_hsa040680.83979695
62DNA replication_Homo sapiens_hsa030300.80643583
63MicroRNAs in cancer_Homo sapiens_hsa052060.79602729
64African trypanosomiasis_Homo sapiens_hsa051430.79447455
65Glioma_Homo sapiens_hsa052140.78397464
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77516089
67Nitrogen metabolism_Homo sapiens_hsa009100.77467402
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.77193184
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74476369
70TNF signaling pathway_Homo sapiens_hsa046680.71868842
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71402907
72Homologous recombination_Homo sapiens_hsa034400.69287838
73Inositol phosphate metabolism_Homo sapiens_hsa005620.69270557
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69147316
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67192369
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64215148
77Prostate cancer_Homo sapiens_hsa052150.62724439
78Hepatitis C_Homo sapiens_hsa051600.61649555
79Tryptophan metabolism_Homo sapiens_hsa003800.60676490
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.60001895
81MAPK signaling pathway_Homo sapiens_hsa040100.57522552
82VEGF signaling pathway_Homo sapiens_hsa043700.56526815
83Butanoate metabolism_Homo sapiens_hsa006500.56117586
84p53 signaling pathway_Homo sapiens_hsa041150.56096776
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55028336
86Spliceosome_Homo sapiens_hsa030400.54329572
87RNA polymerase_Homo sapiens_hsa030200.54267597
88Malaria_Homo sapiens_hsa051440.53901060
89Choline metabolism in cancer_Homo sapiens_hsa052310.53714840
90Caffeine metabolism_Homo sapiens_hsa002320.53103236
91Lysine degradation_Homo sapiens_hsa003100.52604686
92mRNA surveillance pathway_Homo sapiens_hsa030150.51159560
93Fanconi anemia pathway_Homo sapiens_hsa034600.50669581
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50190663
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49222961
96Insulin resistance_Homo sapiens_hsa049310.49030121
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48812290
98Arachidonic acid metabolism_Homo sapiens_hsa005900.48074288
99Cell cycle_Homo sapiens_hsa041100.46744553
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46368054
101Pertussis_Homo sapiens_hsa051330.46130076
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46095735
103Colorectal cancer_Homo sapiens_hsa052100.45537220
104Viral myocarditis_Homo sapiens_hsa054160.43458133
105Phagosome_Homo sapiens_hsa041450.43187053
106ABC transporters_Homo sapiens_hsa020100.40544918
107Salmonella infection_Homo sapiens_hsa051320.40221982
108mTOR signaling pathway_Homo sapiens_hsa041500.40020733
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39328745
110Fat digestion and absorption_Homo sapiens_hsa049750.38668151
111Prolactin signaling pathway_Homo sapiens_hsa049170.38121278
112Allograft rejection_Homo sapiens_hsa053300.37947166
113Type II diabetes mellitus_Homo sapiens_hsa049300.36148619
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35913630
115Endocytosis_Homo sapiens_hsa041440.35618037
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35268557
117Olfactory transduction_Homo sapiens_hsa047400.33782146
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32958042
119Legionellosis_Homo sapiens_hsa051340.31448160
120Vitamin digestion and absorption_Homo sapiens_hsa049770.30975683
121Ribosome_Homo sapiens_hsa030100.30827753
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29404576
123Taste transduction_Homo sapiens_hsa047420.29129872
124RNA degradation_Homo sapiens_hsa030180.28967698
125Pathways in cancer_Homo sapiens_hsa052000.28908229
126Notch signaling pathway_Homo sapiens_hsa043300.28818070
127ErbB signaling pathway_Homo sapiens_hsa040120.28502070
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28225330
129Renal cell carcinoma_Homo sapiens_hsa052110.27421721
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27124010
131Morphine addiction_Homo sapiens_hsa050320.26510729
132Serotonergic synapse_Homo sapiens_hsa047260.26197989
133Proteoglycans in cancer_Homo sapiens_hsa052050.26038587
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.25898370
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.25682372
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25234028
137Endometrial cancer_Homo sapiens_hsa052130.24281431
138One carbon pool by folate_Homo sapiens_hsa006700.24184577
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22179167
140Oxidative phosphorylation_Homo sapiens_hsa001900.22111105
141Glycerolipid metabolism_Homo sapiens_hsa005610.21015266
142Pyrimidine metabolism_Homo sapiens_hsa002400.20608593
143Parkinsons disease_Homo sapiens_hsa050120.19204862
144Peroxisome_Homo sapiens_hsa041460.15107370
145Regulation of autophagy_Homo sapiens_hsa041400.14645677
146Nicotine addiction_Homo sapiens_hsa050330.13623303
147Sulfur relay system_Homo sapiens_hsa041220.13506355
148Basal transcription factors_Homo sapiens_hsa030220.12559995
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12248767
150Dorso-ventral axis formation_Homo sapiens_hsa043200.10418818
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10259251
152Calcium signaling pathway_Homo sapiens_hsa040200.07577789
153Ovarian steroidogenesis_Homo sapiens_hsa049130.06443919

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