SPIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenylpropanoid metabolic process (GO:0009698)7.23029520
2purine nucleobase biosynthetic process (GO:0009113)7.17899931
3vitamin transmembrane transport (GO:0035461)6.28566014
4mitotic metaphase plate congression (GO:0007080)6.19032628
5urea metabolic process (GO:0019627)6.08310912
6nitrogen cycle metabolic process (GO:0071941)6.07602027
7nucleobase biosynthetic process (GO:0046112)6.06958105
8omega-hydroxylase P450 pathway (GO:0097267)6.04423875
9ribosome assembly (GO:0042255)5.79175036
10urea cycle (GO:0000050)5.66896920
11epoxygenase P450 pathway (GO:0019373)5.65912731
12glyoxylate metabolic process (GO:0046487)5.57825016
13NADH metabolic process (GO:0006734)5.50208149
14regulation of spindle organization (GO:0090224)5.39897571
15serine family amino acid catabolic process (GO:0009071)5.35296684
16protein-cofactor linkage (GO:0018065)5.32514972
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.23437713
18ribosome biogenesis (GO:0042254)5.14318073
19oxidative demethylation (GO:0070989)5.06905530
20transcription elongation from RNA polymerase III promoter (GO:0006385)5.00278017
21termination of RNA polymerase III transcription (GO:0006386)5.00278017
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.96463457
23rRNA modification (GO:0000154)4.89754228
24alkaloid metabolic process (GO:0009820)4.87784886
25L-phenylalanine catabolic process (GO:0006559)4.80543871
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80543871
27transcription elongation from RNA polymerase I promoter (GO:0006362)4.68644290
28drug catabolic process (GO:0042737)4.67675012
29metaphase plate congression (GO:0051310)4.67597015
30termination of RNA polymerase I transcription (GO:0006363)4.67141047
31DNA replication checkpoint (GO:0000076)4.64981200
32protein carboxylation (GO:0018214)4.64333741
33peptidyl-glutamic acid carboxylation (GO:0017187)4.64333741
34complement activation, alternative pathway (GO:0006957)4.51298705
35bile acid biosynthetic process (GO:0006699)4.48635828
36regulation of protein activation cascade (GO:2000257)4.48031587
377-methylguanosine mRNA capping (GO:0006370)4.46547041
38transcription from RNA polymerase I promoter (GO:0006360)4.45375001
39lung-associated mesenchyme development (GO:0060484)4.42773375
40protein K6-linked ubiquitination (GO:0085020)4.42615144
41regulation of mitotic spindle organization (GO:0060236)4.39070757
42folic acid metabolic process (GO:0046655)4.38657417
43RNA capping (GO:0036260)4.37515417
447-methylguanosine RNA capping (GO:0009452)4.37515417
45regulation of bile acid biosynthetic process (GO:0070857)4.31892908
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.31052745
47blood coagulation, intrinsic pathway (GO:0007597)4.27057300
48oxaloacetate metabolic process (GO:0006107)4.26772965
49folic acid transport (GO:0015884)4.24853248
50proteasome assembly (GO:0043248)4.23555616
51positive regulation of chromosome segregation (GO:0051984)4.23374607
52diterpenoid biosynthetic process (GO:0016102)4.20990696
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.19907944
54imidazole-containing compound metabolic process (GO:0052803)4.19739358
55flavonoid metabolic process (GO:0009812)4.17768182
56drug metabolic process (GO:0017144)4.17115267
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.17017284
58L-phenylalanine metabolic process (GO:0006558)4.17017284
59regulation of fibrinolysis (GO:0051917)4.16978674
60transcription initiation from RNA polymerase I promoter (GO:0006361)4.14870182
61intestinal epithelial cell development (GO:0060576)4.14524618
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12504951
63regulation of complement activation (GO:0030449)4.05042936
64glycine metabolic process (GO:0006544)4.02564567
65ethanol oxidation (GO:0006069)4.01320989
66positive regulation of triglyceride lipase activity (GO:0061365)3.91833921
67positive regulation of lipoprotein lipase activity (GO:0051006)3.91833921
68spindle checkpoint (GO:0031577)3.91515870
69regulation of G0 to G1 transition (GO:0070316)3.89950208
70protein localization to kinetochore (GO:0034501)3.85922412
71maturation of 5.8S rRNA (GO:0000460)3.85127655
72serine family amino acid biosynthetic process (GO:0009070)3.82300668
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81691010
74methionine biosynthetic process (GO:0009086)3.79013002
75rRNA methylation (GO:0031167)3.75456406
76sulfur amino acid catabolic process (GO:0000098)3.75285906
77GMP metabolic process (GO:0046037)3.75028985
78regulation of exit from mitosis (GO:0007096)3.73535686
79regulation of gene expression by genetic imprinting (GO:0006349)3.73227786
80bile acid metabolic process (GO:0008206)3.71918360
81attachment of spindle microtubules to kinetochore (GO:0008608)3.69910149
82xenobiotic catabolic process (GO:0042178)3.68241664
83ribonucleoprotein complex biogenesis (GO:0022613)3.67271890
84establishment of chromosome localization (GO:0051303)3.65837636
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65498040
86mitotic spindle checkpoint (GO:0071174)3.63922708
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63902316
88pantothenate metabolic process (GO:0015939)3.62470051
89arginine metabolic process (GO:0006525)3.61229721
90serine family amino acid metabolic process (GO:0009069)3.60432797
91regulation of triglyceride catabolic process (GO:0010896)3.59020344
92S-adenosylmethionine metabolic process (GO:0046500)3.57531905
93meiosis I (GO:0007127)3.56516694
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.55945926
95amino acid salvage (GO:0043102)3.55339177
96L-methionine salvage (GO:0071267)3.55339177
97L-methionine biosynthetic process (GO:0071265)3.55339177
98regulation of chromosome segregation (GO:0051983)3.55306128
99DNA-templated transcription, elongation (GO:0006354)3.54853709
100CENP-A containing nucleosome assembly (GO:0034080)3.53717542
101sulfur amino acid biosynthetic process (GO:0000097)3.53564642
102negative regulation of fibrinolysis (GO:0051918)3.53321799
103DNA deamination (GO:0045006)3.53272148
104transcription elongation from RNA polymerase II promoter (GO:0006368)3.51977545
105transcription from mitochondrial promoter (GO:0006390)3.51557477
106kinetochore assembly (GO:0051382)3.48435655
107regulation of translation in response to stress (GO:0043555)3.47720947
108high-density lipoprotein particle remodeling (GO:0034375)3.47287808
109rRNA processing (GO:0006364)3.47101828
110negative regulation of chromosome segregation (GO:0051985)3.47093327
111steroid catabolic process (GO:0006706)3.47021193
112negative regulation of mitotic sister chromatid separation (GO:2000816)3.46179483
113negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46179483
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46179483
115negative regulation of sister chromatid segregation (GO:0033046)3.46179483
116protein localization to chromosome, centromeric region (GO:0071459)3.45754184
117mitotic spindle assembly checkpoint (GO:0007094)3.41894256
118pentose metabolic process (GO:0019321)3.41735930
119ethanol metabolic process (GO:0006067)3.41306579
120positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.41243653
121regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39012278
122rRNA metabolic process (GO:0016072)3.38818493
123spliceosomal snRNP assembly (GO:0000387)3.36996794
124spindle assembly checkpoint (GO:0071173)3.36598676
125triglyceride homeostasis (GO:0070328)3.36388560
126acylglycerol homeostasis (GO:0055090)3.36388560
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35523237
128positive regulation of viral transcription (GO:0050434)3.34696375
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34328427
130sterol catabolic process (GO:0016127)3.31758178
131cholesterol catabolic process (GO:0006707)3.31758178
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30940797
133ubiquinone biosynthetic process (GO:0006744)3.29767230
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28814916
135alpha-amino acid catabolic process (GO:1901606)3.28722716
136inner cell mass cell proliferation (GO:0001833)3.28225396
137aromatic amino acid family catabolic process (GO:0009074)3.27979402
138complement activation, classical pathway (GO:0006958)3.27657008
139oocyte maturation (GO:0001556)3.25570168
140negative regulation of microtubule polymerization (GO:0031115)3.25508164
141histone exchange (GO:0043486)3.25105749
142histone-serine phosphorylation (GO:0035404)3.23798726
143mitochondrial RNA metabolic process (GO:0000959)3.23316162
144chromatin remodeling at centromere (GO:0031055)3.22800468
145methionine metabolic process (GO:0006555)3.20624316
146protein activation cascade (GO:0072376)3.20045725
147L-serine metabolic process (GO:0006563)3.19893259
148DNA-dependent DNA replication (GO:0006261)3.19097564
149regulation of sister chromatid segregation (GO:0033045)3.17932793
150regulation of mitotic sister chromatid separation (GO:0010965)3.17932793
151regulation of mitotic sister chromatid segregation (GO:0033047)3.17932793
152DNA replication-independent nucleosome organization (GO:0034724)3.17197010
153DNA replication-independent nucleosome assembly (GO:0006336)3.17197010
154monoubiquitinated protein deubiquitination (GO:0035520)3.15281293
155mitotic nuclear envelope disassembly (GO:0007077)3.14511418
156DNA replication initiation (GO:0006270)3.13991139
157very-low-density lipoprotein particle assembly (GO:0034379)3.13970108
158fibrinolysis (GO:0042730)3.13585520
159regulation of nuclear cell cycle DNA replication (GO:0033262)3.13151504
160microtubule depolymerization (GO:0007019)3.13041101
161complement activation (GO:0006956)3.13009451
162replication fork processing (GO:0031297)3.12589243
163regulation of double-strand break repair via homologous recombination (GO:0010569)3.12518845
164regulation of DNA methylation (GO:0044030)3.12365487
165synaptonemal complex assembly (GO:0007130)3.12258580
166positive regulation of ligase activity (GO:0051351)3.11761445
167ribonucleoprotein complex disassembly (GO:0032988)3.10947835
168vitamin D metabolic process (GO:0042359)3.10620520
169transcription from RNA polymerase III promoter (GO:0006383)3.09900061
170response to xenobiotic stimulus (GO:0009410)3.09640458
171negative regulation of macroautophagy (GO:0016242)3.08977383
172transcription-coupled nucleotide-excision repair (GO:0006283)3.08285053
173protein-lipid complex remodeling (GO:0034368)3.07962079
174macromolecular complex remodeling (GO:0034367)3.07962079
175plasma lipoprotein particle remodeling (GO:0034369)3.07962079
176bile acid and bile salt transport (GO:0015721)3.07484044
177fat-soluble vitamin biosynthetic process (GO:0042362)3.06284258
178hydrogen peroxide biosynthetic process (GO:0050665)3.05811387
179cellular response to fluid shear stress (GO:0071498)3.05047625
180nucleotide transmembrane transport (GO:1901679)3.04270035
181epithelial cell differentiation involved in kidney development (GO:0035850)3.03061364
182nucleotide transport (GO:0006862)3.02398104
183mitochondrion distribution (GO:0048311)3.01982564
184aspartate family amino acid biosynthetic process (GO:0009067)2.98542760
185germinal center formation (GO:0002467)2.97407761
186regulation of humoral immune response (GO:0002920)2.95935387
187positive regulation of protein homodimerization activity (GO:0090073)2.93950368
188cellular amino acid catabolic process (GO:0009063)2.91233962
189quinone biosynthetic process (GO:1901663)2.91229854
190secondary heart field specification (GO:0003139)2.90539501
191heart field specification (GO:0003128)2.90539501
192tricarboxylic acid cycle (GO:0006099)2.80319839
193cysteine metabolic process (GO:0006534)2.79832176
194cellular glucuronidation (GO:0052695)2.79451060
195uronic acid metabolic process (GO:0006063)2.78616727
196glucuronate metabolic process (GO:0019585)2.78616727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.29687396
2E2F7_22180533_ChIP-Seq_HELA_Human5.70850986
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.48026807
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45501260
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.04583819
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04174559
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77476410
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.74086047
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.61720854
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53038858
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.53015072
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.46842124
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.40465127
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.27108988
15E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20167485
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.19129366
17RXR_22158963_ChIP-Seq_LIVER_Mouse3.04299603
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.98207688
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94075514
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78392464
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62259838
22VDR_23849224_ChIP-Seq_CD4+_Human2.59320479
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55237100
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51494888
25AR_21909140_ChIP-Seq_LNCAP_Human2.46969352
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.41777299
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38928112
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29286565
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24438925
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22436570
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18146098
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09927430
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05593606
34LXR_22158963_ChIP-Seq_LIVER_Mouse2.04612415
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04464092
36IRF1_19129219_ChIP-ChIP_H3396_Human2.01802705
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00327775
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95826577
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94059170
40GABP_19822575_ChIP-Seq_HepG2_Human1.93820683
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89697666
42XRN2_22483619_ChIP-Seq_HELA_Human1.89108733
43FOXP3_21729870_ChIP-Seq_TREG_Human1.88751483
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.87824713
45* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.85764642
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85238308
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84528020
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81425026
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78477315
50DCP1A_22483619_ChIP-Seq_HELA_Human1.74954148
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71092422
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70844699
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70087189
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.62221177
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.61944009
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61492812
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59839404
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.57617901
59ELK1_19687146_ChIP-ChIP_HELA_Human1.55947013
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52200576
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49911391
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49172404
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46657391
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.46257007
65KDM5A_27292631_Chip-Seq_BREAST_Human1.45697120
66* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.44307576
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.42962604
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.42196261
69BCOR_27268052_Chip-Seq_Bcells_Human1.42013459
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39860492
71HTT_18923047_ChIP-ChIP_STHdh_Human1.39525063
72TTF2_22483619_ChIP-Seq_HELA_Human1.38809148
73ERA_21632823_ChIP-Seq_H3396_Human1.37048815
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36029709
75ZNF263_19887448_ChIP-Seq_K562_Human1.35375629
76E2F1_20622854_ChIP-Seq_HELA_Human1.29004405
77* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28748263
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26881283
79P300_27268052_Chip-Seq_Bcells_Human1.25479733
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23219761
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22397932
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20692796
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20679477
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19598308
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18817491
86* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17608786
87RAC3_21632823_ChIP-Seq_H3396_Human1.16176483
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15796527
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14124125
90* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13089740
91STAT1_20625510_ChIP-Seq_HELA_Human1.12777241
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10123297
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09722405
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.08903511
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08885667
96* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08284924
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08117588
98OCT4_20526341_ChIP-Seq_ESCs_Human1.06749506
99* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05226279
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05050791
101* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02509938
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01425117
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01372995
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00924985
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00917510
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99989940
107CTCF_20526341_ChIP-Seq_ESCs_Human0.99288275
108BCL6_27268052_Chip-Seq_Bcells_Human0.98749619
109MYC_19829295_ChIP-Seq_ESCs_Human0.97181998
110LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96414427
111* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96225879
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96213971
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96056677
114CIITA_25753668_ChIP-Seq_RAJI_Human0.95965134
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95519689
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93492855
117PHF8_20622854_ChIP-Seq_HELA_Human0.93020439
118* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91977577
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91785117
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.91125149
121* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89796181
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89338451
123* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88931760
124* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88276882
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87763934
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85854274
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84107965
128* KAP1_27257070_Chip-Seq_ESCs_Mouse0.83889641
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83800064
130* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82191834
131* NANOG_21062744_ChIP-ChIP_HESCs_Human0.81824055
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81359706
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80873793
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80399736
135* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78999660
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78777011
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76879628
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76879628
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76879628
140* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76511277
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75376278
142* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75026372
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74679252
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74529674
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74325735
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.73901902
147FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73267515
148* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.72340410
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71861808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.63531928
2MP0003693_abnormal_embryo_hatching6.59528504
3MP0005360_urolithiasis6.29218549
4MP0003718_maternal_effect5.26816314
5MP0003111_abnormal_nucleus_morphology5.14820143
6MP0002138_abnormal_hepatobiliary_system4.98217952
7MP0005085_abnormal_gallbladder_physiolo4.83378411
8MP0003806_abnormal_nucleotide_metabolis4.63308489
9MP0005365_abnormal_bile_salt4.20117908
10MP0008260_abnormal_autophagy3.98192053
11MP0010094_abnormal_chromosome_stability3.96276882
12MP0008875_abnormal_xenobiotic_pharmacok3.85534010
13MP0004957_abnormal_blastocyst_morpholog3.74381926
14MP0003077_abnormal_cell_cycle3.73995840
15MP0008058_abnormal_DNA_repair3.52225596
16MP0008057_abnormal_DNA_replication3.46017393
17MP0003868_abnormal_feces_composition2.83540410
18MP0003786_premature_aging2.74866402
19MP0002876_abnormal_thyroid_physiology2.48659486
20MP0003123_paternal_imprinting2.44562511
21MP0008007_abnormal_cellular_replicative2.40393447
22MP0002254_reproductive_system_inflammat2.37153859
23MP0003191_abnormal_cellular_cholesterol2.36647197
24MP0009697_abnormal_copulation2.35287458
25MP0008877_abnormal_DNA_methylation2.30002133
26MP0003878_abnormal_ear_physiology2.26302701
27MP0005377_hearing/vestibular/ear_phenot2.26302701
28MP0010329_abnormal_lipoprotein_level2.19139052
29MP0002396_abnormal_hematopoietic_system2.14374029
30MP0008932_abnormal_embryonic_tissue2.14329148
31MP0005451_abnormal_body_composition2.10867604
32MP0006292_abnormal_olfactory_placode2.06715094
33MP0003195_calcinosis1.98970167
34MP0009840_abnormal_foam_cell1.97645015
35MP0001730_embryonic_growth_arrest1.95731634
36MP0005395_other_phenotype1.93562420
37MP0001661_extended_life_span1.87482356
38MP0003252_abnormal_bile_duct1.80685888
39MP0005084_abnormal_gallbladder_morpholo1.79734641
40MP0000350_abnormal_cell_proliferation1.78102197
41MP0010307_abnormal_tumor_latency1.76772531
42MP0009333_abnormal_splenocyte_physiolog1.75657272
43MP0003941_abnormal_skin_development1.75564196
44MP0001542_abnormal_bone_strength1.68189746
45MP0002102_abnormal_ear_morphology1.62463139
46MP0001672_abnormal_embryogenesis/_devel1.61225382
47MP0005380_embryogenesis_phenotype1.61225382
48MP0001666_abnormal_nutrient_absorption1.58014171
49MP0002090_abnormal_vision1.57766452
50MP0003646_muscle_fatigue1.53290184
51MP0002210_abnormal_sex_determination1.53132729
52MP0008872_abnormal_physiological_respon1.52802290
53MP0001986_abnormal_taste_sensitivity1.49319739
54MP0003315_abnormal_perineum_morphology1.46963840
55MP0003938_abnormal_ear_development1.46184037
56MP0002132_abnormal_respiratory_system1.45286348
57MP0008874_decreased_physiological_sensi1.37985138
58MP0002163_abnormal_gland_morphology1.37569598
59MP0009278_abnormal_bone_marrow1.35260742
60MP0003984_embryonic_growth_retardation1.29626808
61MP0003221_abnormal_cardiomyocyte_apopto1.28021579
62MP0001929_abnormal_gametogenesis1.27444438
63MP0002277_abnormal_respiratory_mucosa1.27116573
64MP0001145_abnormal_male_reproductive1.27048241
65MP0003787_abnormal_imprinting1.25167690
66MP0002088_abnormal_embryonic_growth/wei1.25026412
67MP0005319_abnormal_enzyme/_coenzyme1.23248908
68MP0000653_abnormal_sex_gland1.20996792
69MP0008961_abnormal_basal_metabolism1.20076049
70MP0005397_hematopoietic_system_phenotyp1.19186436
71MP0001545_abnormal_hematopoietic_system1.19186436
72MP0000750_abnormal_muscle_regeneration1.18961184
73MP0000609_abnormal_liver_physiology1.18157823
74MP0009765_abnormal_xenobiotic_induced1.17921246
75MP0003303_peritoneal_inflammation1.17523045
76MP0009046_muscle_twitch1.15747987
77* MP0002080_prenatal_lethality1.14526078
78MP0003136_yellow_coat_color1.13041705
79MP0006036_abnormal_mitochondrial_physio1.11405150
80MP0001697_abnormal_embryo_size1.10556869
81MP0001984_abnormal_olfaction1.09825155
82MP0001119_abnormal_female_reproductive1.09349648
83MP0003567_abnormal_fetal_cardiomyocyte1.09231491
84MP0003890_abnormal_embryonic-extraembry1.08995080
85MP0005058_abnormal_lysosome_morphology1.06649552
86MP0005584_abnormal_enzyme/coenzyme_acti1.04076943
87MP0003699_abnormal_female_reproductive1.03467362
88MP0004019_abnormal_vitamin_homeostasis1.02980858
89MP0003879_abnormal_hair_cell1.02833220
90MP0009764_decreased_sensitivity_to1.01883430
91MP0002118_abnormal_lipid_homeostasis1.00772098
92MP0000313_abnormal_cell_death0.97463792
93MP0000566_synostosis0.97037322
94MP0002909_abnormal_adrenal_gland0.96682640
95MP0001756_abnormal_urination0.94417268
96MP0000627_abnormal_mammary_gland0.94169864
97MP0002085_abnormal_embryonic_tissue0.93873921
98MP0005621_abnormal_cell_physiology0.93371696
99MP0009785_altered_susceptibility_to0.92874878
100MP0000598_abnormal_liver_morphology0.90922361
101MP0008995_early_reproductive_senescence0.90469284
102MP0009763_increased_sensitivity_to0.89575683
103MP0009672_abnormal_birth_weight0.88666794
104MP0002086_abnormal_extraembryonic_tissu0.88290126
105MP0008873_increased_physiological_sensi0.85935100
106MP0005376_homeostasis/metabolism_phenot0.85576354
107MP0001188_hyperpigmentation0.85464710
108MP0005464_abnormal_platelet_physiology0.85109070
109MP0005083_abnormal_biliary_tract0.84299841
110MP0003937_abnormal_limbs/digits/tail_de0.84173967
111MP0005384_cellular_phenotype0.83358523
112MP0000647_abnormal_sebaceous_gland0.82978498
113MP0005647_abnormal_sex_gland0.82732530
114MP0000383_abnormal_hair_follicle0.78723258
115MP0005389_reproductive_system_phenotype0.78197014
116MP0002735_abnormal_chemical_nociception0.78117224
117MP0002019_abnormal_tumor_incidence0.76352041
118MP0000685_abnormal_immune_system0.75609081
119MP0005646_abnormal_pituitary_gland0.74607754
120MP0002161_abnormal_fertility/fecundity0.73883979
121MP0005408_hypopigmentation0.72845983
122MP0005187_abnormal_penis_morphology0.72472050
123MP0001764_abnormal_homeostasis0.72298824
124MP0000639_abnormal_adrenal_gland0.72086391
125MP0009643_abnormal_urine_homeostasis0.71736862
126MP0000604_amyloidosis0.70461838
127MP0000490_abnormal_crypts_of0.70418360
128MP0003698_abnormal_male_reproductive0.70368806
129MP0004808_abnormal_hematopoietic_stem0.68302925
130MP0000428_abnormal_craniofacial_morphol0.68032779
131MP0004859_abnormal_synaptic_plasticity0.67959829
132MP0002084_abnormal_developmental_patter0.65701450
133MP0001293_anophthalmia0.65603687
134MP0004885_abnormal_endolymph0.65322706
135MP0000358_abnormal_cell_content/0.64707996
136MP0003936_abnormal_reproductive_system0.64266216
137MP0002160_abnormal_reproductive_system0.64237178
138MP0004233_abnormal_muscle_weight0.62848370
139MP0005310_abnormal_salivary_gland0.62743854
140MP0002009_preneoplasia0.62741993
141MP0000751_myopathy0.61662711
142MP0003186_abnormal_redox_activity0.60469363
143MP0003656_abnormal_erythrocyte_physiolo0.59465201
144MP0003828_pulmonary_edema0.58747847
145MP0006035_abnormal_mitochondrial_morpho0.58696883
146MP0003763_abnormal_thymus_physiology0.56658867
147MP0002653_abnormal_ependyma_morphology0.56628115
148MP0000015_abnormal_ear_pigmentation0.56534333
149MP0005670_abnormal_white_adipose0.55928729
150MP0009703_decreased_birth_body0.55873597
151MP0005671_abnormal_response_to0.55838622
152MP0005025_abnormal_response_to0.55804637
153MP0001873_stomach_inflammation0.55347534
154MP0003121_genomic_imprinting0.54862211
155MP0003075_altered_response_to0.54583539
156MP0002092_abnormal_eye_morphology0.54441174
157MP0005379_endocrine/exocrine_gland_phen0.54357152
158MP0009642_abnormal_blood_homeostasis0.54341747
159MP0001346_abnormal_lacrimal_gland0.54104326
160MP0005257_abnormal_intraocular_pressure0.53850829
161MP0004381_abnormal_hair_follicle0.53532884
162MP0004142_abnormal_muscle_tone0.53434978
163MP0008469_abnormal_protein_level0.53051265
164MP0008789_abnormal_olfactory_epithelium0.50981125
165MP0001845_abnormal_inflammatory_respons0.50230965
166MP0005166_decreased_susceptibility_to0.49789721
167MP0002095_abnormal_skin_pigmentation0.49745434
168MP0004924_abnormal_behavior0.49651241
169MP0005386_behavior/neurological_phenoty0.49651241
170MP0004084_abnormal_cardiac_muscle0.49556275
171MP0005076_abnormal_cell_differentiation0.49267894
172MP0005332_abnormal_amino_acid0.49149451
173MP0000470_abnormal_stomach_morphology0.48340804
174* MP0005636_abnormal_mineral_homeostasis0.48158264
175MP0002127_abnormal_cardiovascular_syste0.45662273
176MP0003183_abnormal_peptide_metabolism0.45329159
177MP0002332_abnormal_exercise_endurance0.45120005
178MP0004883_abnormal_blood_vessel0.44463815
179MP0000467_abnormal_esophagus_morphology0.43557884
180MP0005266_abnormal_metabolism0.43225370
181MP0010386_abnormal_urinary_bladder0.43185392
182MP0009115_abnormal_fat_cell0.42418847

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98613013
2Deep venous thrombosis (HP:0002625)5.88832135
3Birth length less than 3rd percentile (HP:0003561)5.52949918
4Breast hypoplasia (HP:0003187)5.40684873
5Prolonged partial thromboplastin time (HP:0003645)5.10785274
6Hyperglycinemia (HP:0002154)5.06402254
7Impulsivity (HP:0100710)4.82471294
8Hyperlipoproteinemia (HP:0010980)4.66115266
9Limb dystonia (HP:0002451)4.65699947
10Carpal bone hypoplasia (HP:0001498)4.65146337
11Abnormality of pyrimidine metabolism (HP:0004353)4.43949765
12Rough bone trabeculation (HP:0100670)4.18709937
13Cerebral hypomyelination (HP:0006808)4.12658154
14Hyperglycinuria (HP:0003108)4.12634677
15Systemic lupus erythematosus (HP:0002725)4.08286632
16Patellar aplasia (HP:0006443)3.99147732
17Dysphonia (HP:0001618)3.96819483
18Aplasia/Hypoplasia of the patella (HP:0006498)3.91143512
19Hyperammonemia (HP:0001987)3.72042360
20Delayed CNS myelination (HP:0002188)3.66275702
21Complement deficiency (HP:0004431)3.64703797
223-Methylglutaconic aciduria (HP:0003535)3.64228646
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.63519964
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63318112
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.62516805
26Entropion (HP:0000621)3.60768500
27Gout (HP:0001997)3.40489779
28Ureteral duplication (HP:0000073)3.38921218
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.35011459
30Cerebral edema (HP:0002181)3.31004287
31Chromsome breakage (HP:0040012)3.28999276
32Sensorimotor neuropathy (HP:0007141)3.22222967
33Abnormal trabecular bone morphology (HP:0100671)3.20994123
34Abnormality of glycine metabolism (HP:0010895)3.19738922
35Abnormality of serine family amino acid metabolism (HP:0010894)3.19738922
36Abnormality of the labia minora (HP:0012880)3.18296793
37Pustule (HP:0200039)3.17935355
38Generalized aminoaciduria (HP:0002909)3.08855512
39Absent radius (HP:0003974)3.08025214
40Abnormal spermatogenesis (HP:0008669)3.06515852
41Microvesicular hepatic steatosis (HP:0001414)3.05835602
42Meckel diverticulum (HP:0002245)3.05425956
43Multiple enchondromatosis (HP:0005701)3.04025747
44Abnormality of the preputium (HP:0100587)3.02759871
45Increased muscle lipid content (HP:0009058)3.02670964
46Oligodactyly (hands) (HP:0001180)3.01332587
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.99254302
48Abnormal mitochondria in muscle tissue (HP:0008316)2.98919744
49Split foot (HP:0001839)2.97885301
50Lethargy (HP:0001254)2.94661649
51Abnormality of complement system (HP:0005339)2.94533699
52Acute necrotizing encephalopathy (HP:0006965)2.94332915
53Joint hemorrhage (HP:0005261)2.93826880
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89379977
55Aplasia involving forearm bones (HP:0009822)2.88354691
56Absent forearm bone (HP:0003953)2.88354691
57Hypobetalipoproteinemia (HP:0003563)2.87217259
58Secondary amenorrhea (HP:0000869)2.84959494
59Acute encephalopathy (HP:0006846)2.83865902
60Abnormal gallbladder physiology (HP:0012438)2.82694088
61Cholecystitis (HP:0001082)2.82694088
62Spontaneous abortion (HP:0005268)2.80310696
63Abnormality of the ileum (HP:0001549)2.80189720
64Tetraplegia (HP:0002445)2.79735969
65Areflexia of lower limbs (HP:0002522)2.75061349
66Abnormality of the umbilical cord (HP:0010881)2.74493190
67Lipid accumulation in hepatocytes (HP:0006561)2.74312531
68Abnormality of serum amino acid levels (HP:0003112)2.74153417
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71945088
70Poor suck (HP:0002033)2.71905093
71Reduced antithrombin III activity (HP:0001976)2.71186662
72Increased CSF lactate (HP:0002490)2.66525199
73Pancreatic fibrosis (HP:0100732)2.64383059
74Azoospermia (HP:0000027)2.63790720
75Conjugated hyperbilirubinemia (HP:0002908)2.62610919
76Myokymia (HP:0002411)2.61512392
77Progressive muscle weakness (HP:0003323)2.60732967
78Increased serum lactate (HP:0002151)2.60625811
79Congenital, generalized hypertrichosis (HP:0004540)2.59864705
80Death in infancy (HP:0001522)2.58476816
81Premature ovarian failure (HP:0008209)2.56081454
82CNS hypomyelination (HP:0003429)2.51191915
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.50508863
84Intrahepatic cholestasis (HP:0001406)2.49723588
85Abnormality of chromosome stability (HP:0003220)2.49584151
86Prostate neoplasm (HP:0100787)2.49403171
87Sparse eyelashes (HP:0000653)2.48652424
88Atrioventricular block (HP:0001678)2.47315024
89Abnormality of alanine metabolism (HP:0010916)2.45645540
90Hyperalaninemia (HP:0003348)2.45645540
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45645540
92Lactic acidosis (HP:0003128)2.45044026
93Capillary hemangiomas (HP:0005306)2.44613027
94Increased intramyocellular lipid droplets (HP:0012240)2.42188080
95Facial hemangioma (HP:0000329)2.41429141
96Asplenia (HP:0001746)2.41264443
97Sparse lateral eyebrow (HP:0005338)2.41101136
98Breast aplasia (HP:0100783)2.41005510
99Degeneration of anterior horn cells (HP:0002398)2.40231993
100Abnormality of the anterior horn cell (HP:0006802)2.40231993
101Increased serum ferritin (HP:0003281)2.39607471
102Oral leukoplakia (HP:0002745)2.39377504
103Mitochondrial inheritance (HP:0001427)2.37876017
104Flat capital femoral epiphysis (HP:0003370)2.37116059
105Bone marrow hypocellularity (HP:0005528)2.34042908
106Xanthomatosis (HP:0000991)2.33299737
107Dicarboxylic aciduria (HP:0003215)2.32299895
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32299895
109Oligodactyly (HP:0012165)2.32086172
110Abnormality of fatty-acid metabolism (HP:0004359)2.31763031
111Cholelithiasis (HP:0001081)2.31706899
112Osteolytic defects of the hand bones (HP:0009699)2.31434740
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.31434740
114Stillbirth (HP:0003826)2.30970359
115Horseshoe kidney (HP:0000085)2.30886031
116Abnormality of nucleobase metabolism (HP:0010932)2.28861710
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28359178
118Irregular epiphyses (HP:0010582)2.28245766
119Bundle branch block (HP:0011710)2.27478910
120Dysautonomia (HP:0002459)2.27199477
121Microretrognathia (HP:0000308)2.26954549
122Aplasia/Hypoplasia of the breasts (HP:0010311)2.26001411
123Segmental peripheral demyelination/remyelination (HP:0003481)2.23274255
124Aplasia/hypoplasia of the uterus (HP:0008684)2.23118191
125Progressive cerebellar ataxia (HP:0002073)2.22353193
126Action tremor (HP:0002345)2.21790395
127Mutism (HP:0002300)2.21380940
128Muscle fiber splitting (HP:0003555)2.20971558
129Absent hand (HP:0004050)2.20607153
130Aplasia/Hypoplasia of the spleen (HP:0010451)2.20412945
131Submucous cleft hard palate (HP:0000176)2.18934655
132Purpura (HP:0000979)2.18609127
133Small epiphyses (HP:0010585)2.18502637
134Short nail (HP:0001799)2.17731848
135Glomerulonephritis (HP:0000099)2.17190480
136Diaphragmatic weakness (HP:0009113)2.16805099
137Alopecia of scalp (HP:0002293)2.15387015
138Torticollis (HP:0000473)2.14776583
139Male infertility (HP:0003251)2.14756909
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13770327
141Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13770327
142Rhabdomyolysis (HP:0003201)2.13205420
143Delusions (HP:0000746)2.12846370
144Progressive macrocephaly (HP:0004481)2.12691168
145Osteomalacia (HP:0002749)2.12354439
146Respiratory difficulties (HP:0002880)2.12287081
147Small intestinal stenosis (HP:0012848)2.10873772
148Duodenal stenosis (HP:0100867)2.10873772
149Paralysis (HP:0003470)2.09847963
150Cleft eyelid (HP:0000625)2.09802389
151Glucose intolerance (HP:0000833)2.09259757
152Metabolic acidosis (HP:0001942)2.09024897
153Abnormality of urine glucose concentration (HP:0011016)2.08908041
154Glycosuria (HP:0003076)2.08908041
155Hypoplasia of the fovea (HP:0007750)2.08614759
156Aplasia/Hypoplasia of the fovea (HP:0008060)2.08614759
157Irritability (HP:0000737)2.07215279
158Ventricular fibrillation (HP:0001663)2.06681128
159Leukodystrophy (HP:0002415)2.06396416
160Absent epiphyses (HP:0010577)2.06354196
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06354196
162Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05926006
163Premature rupture of membranes (HP:0001788)2.05335704
164Hepatocellular necrosis (HP:0001404)2.04547660
165Aplasia/Hypoplasia of the earlobes (HP:0009906)2.03369195
166Amelogenesis imperfecta (HP:0000705)2.01953523
167Abnormal gallbladder morphology (HP:0012437)2.00964901
168Hypomagnesemia (HP:0002917)1.97464079
169Hepatic necrosis (HP:0002605)1.97457370
170Personality changes (HP:0000751)1.96523893
171Craniofacial dystonia (HP:0012179)1.96373190
172Premature graying of hair (HP:0002216)1.94951199
173Hypoplasia of the uterus (HP:0000013)1.93388353
174Spinal muscular atrophy (HP:0007269)1.93161228
175Abnormality of the proximal phalanges of the hand (HP:0009834)1.93096823
176Pancreatic cysts (HP:0001737)1.92699679
177Exercise intolerance (HP:0003546)1.92096540
178Limb hypertonia (HP:0002509)1.91516687
179Abnormality of iron homeostasis (HP:0011031)1.91090520
180Abnormality of the distal phalanges of the toes (HP:0010182)1.90654065
181Methylmalonic aciduria (HP:0012120)1.90549385
182Abnormalities of placenta or umbilical cord (HP:0001194)1.89422645
183Adrenal hypoplasia (HP:0000835)1.86542622
184Prolonged neonatal jaundice (HP:0006579)1.84869282
185Short middle phalanx of the 5th finger (HP:0004220)1.81557131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.29557311
2BUB15.88148961
3WEE14.99942362
4LMTK24.56153757
5AKT34.05417714
6PLK43.86220262
7MAP3K113.60762209
8MAP3K123.41487285
9EIF2AK13.18936963
10SRPK12.94755607
11BRSK22.89275458
12PINK12.78478151
13NEK22.64546845
14PHKG12.58850917
15PHKG22.58850917
16STK162.52098244
17TAOK32.51388819
18MKNK22.33821145
19TSSK62.24794509
20PLK32.23724496
21PLK12.18112039
22MAPK132.07377196
23CCNB12.06153773
24ZAK2.01203292
25SMG11.99718651
26EIF2AK31.96296745
27VRK21.94575461
28BRSK11.86266917
29TTK1.85140027
30ACVR1B1.78004151
31IRAK31.75058420
32MKNK11.71594106
33NME21.60321985
34PRKG21.59639973
35MAP3K141.55651085
36UHMK11.55650538
37WNK41.51237704
38NEK11.48948991
39DYRK31.48162032
40STK391.47214916
41EIF2AK21.44146675
42LATS21.35002251
43STK31.34031440
44STK38L1.33974949
45PIM21.33594007
46CSF1R1.33536407
47CHEK21.33416645
48ARAF1.32588022
49MST41.29246400
50AURKB1.28972010
51TNK21.24618790
52EEF2K1.23425674
53VRK11.22927773
54KDR1.21136129
55CDC71.20805889
56MAP4K11.18667246
57OXSR11.17962114
58PNCK1.13689368
59BRAF1.11466545
60EPHA21.10355039
61MAPK121.06028982
62CDK31.05968763
63DAPK31.04238757
64AURKA1.03787181
65PDK21.01170539
66MAPK70.99791758
67BMX0.99097591
68CDK70.98241115
69PDK40.97303050
70PDK30.97303050
71CAMK40.95903854
72DAPK10.95161208
73CDK120.92584049
74MAP2K40.89351705
75RPS6KA40.84050441
76CHEK10.83445324
77ALK0.80887890
78BCKDK0.80145098
79MAPK40.79297678
80MAP3K60.78600103
81NUAK10.77408388
82NEK60.74869142
83FGR0.73711401
84MAP3K10.72163927
85CDK40.71493289
86STK240.71358988
87ATR0.70640608
88DYRK20.69110069
89PIM10.65347442
90CSNK1G30.60265955
91PRKCI0.59715451
92MAP3K80.59595581
93TESK10.58346004
94CDK20.57346149
95CAMK2B0.56266992
96CSNK1G10.53666115
97CSNK2A10.52032251
98MAP2K20.51848865
99STK40.51632120
100PAK10.50968337
101PRKAA10.50256433
102CDK10.48737895
103FES0.47960442
104BLK0.47791169
105CSNK1A1L0.47237588
106PRKCQ0.47033544
107GRK10.44957521
108PRKACG0.44070482
109MELK0.43944685
110MARK30.42170222
111IKBKB0.40726016
112DMPK0.40528655
113CSNK2A20.39952910
114PRKACB0.39881801
115PKN10.39626150
116RPS6KA50.39569686
117LYN0.39420845
118WNK30.39276936
119LATS10.39084596
120ATM0.38965344
121CSNK1A10.37435998
122LRRK20.35908691
123ABL20.35783736
124JAK30.35401075
125FGFR40.34743890
126RPS6KA20.34381816
127CSNK1G20.31023645
128CSNK1E0.30942643
129PRKACA0.30886270
130PRKCZ0.30463995
131NME10.30443157
132TESK20.29981455
133RAF10.28740193
134PRKG10.28368969
135TYK20.27594135
136PRKCA0.27231602
137PRKCG0.26657624
138GRK60.25992293
139IKBKE0.25953144
140MAPKAPK50.25717651
141RPS6KA60.24737466
142RPS6KA10.23413167
143RIPK40.23180452
144IRAK40.22457721
145TEC0.21873017
146CDK80.21693077
147STK380.21182504
148MAPKAPK30.21178534
149CHUK0.20112210
150CDK150.20095905
151TXK0.12045676
152AKT20.11705697
153MAPK100.11149997
154TAOK20.10852811
155CAMKK20.10433133
156MAP3K50.08860091
157TLK10.08835933
158STK100.08364589
159GSK3B0.08208407
160DYRK1A0.06694353
161PRKAA20.05556236
162MAPK90.05303939

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.56830734
2RNA polymerase_Homo sapiens_hsa030205.28794225
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.72191057
4Primary bile acid biosynthesis_Homo sapiens_hsa001204.09358297
5Proteasome_Homo sapiens_hsa030503.40421693
6Arginine biosynthesis_Homo sapiens_hsa002203.14009209
7RNA transport_Homo sapiens_hsa030133.10694415
8Pyrimidine metabolism_Homo sapiens_hsa002402.75527416
9Complement and coagulation cascades_Homo sapiens_hsa046102.73205960
10Cell cycle_Homo sapiens_hsa041102.58612232
11DNA replication_Homo sapiens_hsa030302.58449793
12Regulation of autophagy_Homo sapiens_hsa041402.51411913
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49997175
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49287513
15Basal transcription factors_Homo sapiens_hsa030222.40196093
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.39340931
17Homologous recombination_Homo sapiens_hsa034402.36002141
18Spliceosome_Homo sapiens_hsa030402.31904251
19Folate biosynthesis_Homo sapiens_hsa007902.25243161
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21965181
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18966428
22Chemical carcinogenesis_Homo sapiens_hsa052042.17793018
23Mismatch repair_Homo sapiens_hsa034302.10903765
24Fanconi anemia pathway_Homo sapiens_hsa034601.98802021
25Nucleotide excision repair_Homo sapiens_hsa034201.94052511
26Purine metabolism_Homo sapiens_hsa002301.89477768
27Vitamin digestion and absorption_Homo sapiens_hsa049771.88878833
28p53 signaling pathway_Homo sapiens_hsa041151.84786528
29Tryptophan metabolism_Homo sapiens_hsa003801.81772463
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80696068
31Pentose phosphate pathway_Homo sapiens_hsa000301.79695145
32Histidine metabolism_Homo sapiens_hsa003401.78950256
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78750661
34Oxidative phosphorylation_Homo sapiens_hsa001901.75872261
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74877180
36Fatty acid degradation_Homo sapiens_hsa000711.73963211
37Base excision repair_Homo sapiens_hsa034101.73167540
38Pyruvate metabolism_Homo sapiens_hsa006201.68810259
39Phenylalanine metabolism_Homo sapiens_hsa003601.67825469
40Parkinsons disease_Homo sapiens_hsa050121.67456066
41Bile secretion_Homo sapiens_hsa049761.67072249
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65249606
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63380024
44Sulfur metabolism_Homo sapiens_hsa009201.59857128
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.51402346
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.49728659
47Tyrosine metabolism_Homo sapiens_hsa003501.42656931
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36635462
49PPAR signaling pathway_Homo sapiens_hsa033201.36107955
50Fatty acid elongation_Homo sapiens_hsa000621.35846851
51Ribosome_Homo sapiens_hsa030101.35342968
52Epstein-Barr virus infection_Homo sapiens_hsa051691.30994850
53Oocyte meiosis_Homo sapiens_hsa041141.26866145
54RNA degradation_Homo sapiens_hsa030181.23355645
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17074515
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.15065847
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14140879
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14023972
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12360358
60Peroxisome_Homo sapiens_hsa041461.11893264
61Staphylococcus aureus infection_Homo sapiens_hsa051501.10566020
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06424343
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05714216
64Systemic lupus erythematosus_Homo sapiens_hsa053220.98733437
65mRNA surveillance pathway_Homo sapiens_hsa030150.97956044
66One carbon pool by folate_Homo sapiens_hsa006700.95212327
67Starch and sucrose metabolism_Homo sapiens_hsa005000.93732090
68Circadian rhythm_Homo sapiens_hsa047100.90878099
69Cardiac muscle contraction_Homo sapiens_hsa042600.78337856
70Fructose and mannose metabolism_Homo sapiens_hsa000510.76964609
71Non-homologous end-joining_Homo sapiens_hsa034500.75819350
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75522325
73Sulfur relay system_Homo sapiens_hsa041220.75188053
74Biosynthesis of amino acids_Homo sapiens_hsa012300.74563956
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71567866
76Butanoate metabolism_Homo sapiens_hsa006500.70488297
77Prion diseases_Homo sapiens_hsa050200.70430381
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.69972082
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65367646
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.63390466
81Propanoate metabolism_Homo sapiens_hsa006400.62488185
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59748142
83N-Glycan biosynthesis_Homo sapiens_hsa005100.58417404
84Alzheimers disease_Homo sapiens_hsa050100.57192420
85Herpes simplex infection_Homo sapiens_hsa051680.55556818
86Fatty acid metabolism_Homo sapiens_hsa012120.55044475
87Sphingolipid metabolism_Homo sapiens_hsa006000.51451675
88Metabolic pathways_Homo sapiens_hsa011000.47919853
89Arachidonic acid metabolism_Homo sapiens_hsa005900.47433360
90Linoleic acid metabolism_Homo sapiens_hsa005910.46036874
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45051991
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44194845
93Antigen processing and presentation_Homo sapiens_hsa046120.43919770
94Caffeine metabolism_Homo sapiens_hsa002320.42843159
95ABC transporters_Homo sapiens_hsa020100.41799101
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.41343836
97Phototransduction_Homo sapiens_hsa047440.39529695
98FoxO signaling pathway_Homo sapiens_hsa040680.38553155
99African trypanosomiasis_Homo sapiens_hsa051430.37962586
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32656493
101Arginine and proline metabolism_Homo sapiens_hsa003300.32422325
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31719357
103Vibrio cholerae infection_Homo sapiens_hsa051100.31368947
104Glutathione metabolism_Homo sapiens_hsa004800.31055505
105Asthma_Homo sapiens_hsa053100.30492342
106Viral carcinogenesis_Homo sapiens_hsa052030.30201727
107Lysosome_Homo sapiens_hsa041420.29985246
108Primary immunodeficiency_Homo sapiens_hsa053400.29533542
109Selenocompound metabolism_Homo sapiens_hsa004500.28189121
110Mineral absorption_Homo sapiens_hsa049780.27036807
111Glycerolipid metabolism_Homo sapiens_hsa005610.26799085
112Rheumatoid arthritis_Homo sapiens_hsa053230.26496414
113Steroid biosynthesis_Homo sapiens_hsa001000.26283423
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.24333676
115Synaptic vesicle cycle_Homo sapiens_hsa047210.24257130
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21735188
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21379751
118beta-Alanine metabolism_Homo sapiens_hsa004100.20793941
119Retinol metabolism_Homo sapiens_hsa008300.20498231
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19741701
121Carbon metabolism_Homo sapiens_hsa012000.18574973
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17108834
123Fat digestion and absorption_Homo sapiens_hsa049750.15981196
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15731639
125Ether lipid metabolism_Homo sapiens_hsa005650.14809069
126Alcoholism_Homo sapiens_hsa050340.14570563
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14481209
128Apoptosis_Homo sapiens_hsa042100.14120845
129HTLV-I infection_Homo sapiens_hsa051660.14058616
130Small cell lung cancer_Homo sapiens_hsa052220.13793229
131Graft-versus-host disease_Homo sapiens_hsa053320.11378321
132Glucagon signaling pathway_Homo sapiens_hsa049220.11018029
133mTOR signaling pathway_Homo sapiens_hsa041500.09320773
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09293252
135Inositol phosphate metabolism_Homo sapiens_hsa005620.08062014
136Measles_Homo sapiens_hsa051620.07387140
137Influenza A_Homo sapiens_hsa051640.06878875
138Renin-angiotensin system_Homo sapiens_hsa046140.06409861
139MicroRNAs in cancer_Homo sapiens_hsa052060.05843931
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05825823
141Legionellosis_Homo sapiens_hsa051340.05576856
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03984953
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.03715517
144Galactose metabolism_Homo sapiens_hsa000520.03708410
145Huntingtons disease_Homo sapiens_hsa050160.03363573
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01990864
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01087003
148HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0095771
149Collecting duct acid secretion_Homo sapiens_hsa04966-0.0058918
150Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0046827
151Allograft rejection_Homo sapiens_hsa05330-0.0024605
152Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0017753

Most similar genes based on co-expression Upload to Enrichr

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