SPICE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.95199827
2DNA strand elongation involved in DNA replication (GO:0006271)4.86067016
3telomere maintenance via semi-conservative replication (GO:0032201)4.82738165
4DNA replication initiation (GO:0006270)4.79405445
5DNA strand elongation (GO:0022616)4.60872513
6mitotic metaphase plate congression (GO:0007080)4.54928064
7telomere maintenance via recombination (GO:0000722)4.43576594
8mitotic recombination (GO:0006312)4.40080349
9centriole replication (GO:0007099)4.38273483
10* metaphase plate congression (GO:0051310)4.36805580
11meiotic chromosome segregation (GO:0045132)4.29862718
12protein localization to kinetochore (GO:0034501)4.20592192
13attachment of spindle microtubules to kinetochore (GO:0008608)4.17579649
14protein localization to chromosome, centromeric region (GO:0071459)4.07521933
15mitotic chromosome condensation (GO:0007076)4.06271183
16DNA replication checkpoint (GO:0000076)4.04451366
17telomere maintenance via telomere lengthening (GO:0010833)3.99783859
18nucleotide-excision repair, DNA gap filling (GO:0006297)3.99309206
19regulation of DNA endoreduplication (GO:0032875)3.96738606
20* regulation of centriole replication (GO:0046599)3.90260532
21kinetochore organization (GO:0051383)3.89607073
22establishment of integrated proviral latency (GO:0075713)3.85430305
23intra-S DNA damage checkpoint (GO:0031573)3.84873780
24CENP-A containing nucleosome assembly (GO:0034080)3.84842752
25chromatin remodeling at centromere (GO:0031055)3.83497696
26DNA double-strand break processing (GO:0000729)3.72401705
27cell wall macromolecule catabolic process (GO:0016998)3.70511261
28* establishment of chromosome localization (GO:0051303)3.69232273
29reciprocal DNA recombination (GO:0035825)3.61005593
30reciprocal meiotic recombination (GO:0007131)3.61005593
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60891413
32IMP biosynthetic process (GO:0006188)3.59952060
33non-recombinational repair (GO:0000726)3.59007814
34double-strand break repair via nonhomologous end joining (GO:0006303)3.59007814
35intraciliary transport (GO:0042073)3.58751828
36mismatch repair (GO:0006298)3.57487019
37DNA replication-independent nucleosome organization (GO:0034724)3.57297473
38DNA replication-independent nucleosome assembly (GO:0006336)3.57297473
39nuclear pore organization (GO:0006999)3.57197189
40mitotic sister chromatid segregation (GO:0000070)3.56168600
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.51836168
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51836168
43recombinational repair (GO:0000725)3.49014942
44double-strand break repair via homologous recombination (GO:0000724)3.48931906
45mitotic nuclear envelope disassembly (GO:0007077)3.46616914
46regulation of sister chromatid cohesion (GO:0007063)3.45503753
47sister chromatid segregation (GO:0000819)3.42717070
48DNA replication-dependent nucleosome assembly (GO:0006335)3.41230249
49DNA replication-dependent nucleosome organization (GO:0034723)3.41230249
50regulation of helicase activity (GO:0051095)3.39588537
51ribosomal small subunit assembly (GO:0000028)3.38580629
52telomere organization (GO:0032200)3.37505596
53telomere maintenance (GO:0000723)3.37382864
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37071425
55DNA strand renaturation (GO:0000733)3.34852236
56nuclear pore complex assembly (GO:0051292)3.34622904
57histone exchange (GO:0043486)3.33777011
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33334054
59protein K6-linked ubiquitination (GO:0085020)3.33300686
60establishment of viral latency (GO:0019043)3.30869531
61synapsis (GO:0007129)3.30755683
62translesion synthesis (GO:0019985)3.29165364
63DNA duplex unwinding (GO:0032508)3.28399618
64DNA geometric change (GO:0032392)3.27160479
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26473903
66regulation of mitotic spindle checkpoint (GO:1903504)3.26473903
67kinetochore assembly (GO:0051382)3.26453673
68* regulation of centrosome duplication (GO:0010824)3.24385326
69membrane disassembly (GO:0030397)3.21700617
70nuclear envelope disassembly (GO:0051081)3.21700617
71IMP metabolic process (GO:0046040)3.21248298
72sister chromatid cohesion (GO:0007062)3.19610909
73regulation of histone H3-K9 methylation (GO:0051570)3.16399111
74cilium or flagellum-dependent cell motility (GO:0001539)3.14909768
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.14182091
76* regulation of centrosome cycle (GO:0046605)3.13182824
77prenylation (GO:0097354)3.13007866
78protein prenylation (GO:0018342)3.13007866
79cilium movement (GO:0003341)3.11512403
80epithelial cilium movement (GO:0003351)3.10413333
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09864927
82histone H2A acetylation (GO:0043968)3.08878742
83DNA ligation (GO:0006266)3.08178658
84interkinetic nuclear migration (GO:0022027)3.07714473
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.06074161
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06074161
87protein localization to chromosome (GO:0034502)3.05633184
88cell wall macromolecule metabolic process (GO:0044036)3.05417774
89DNA topological change (GO:0006265)3.01061716
90snRNA processing (GO:0016180)3.00787966
91DNA conformation change (GO:0071103)2.99607299
92centriole assembly (GO:0098534)2.99458815
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.98669689
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97642480
95negative regulation of mRNA processing (GO:0050686)2.97481691
96monoubiquitinated protein deubiquitination (GO:0035520)2.96490609
97viral transcription (GO:0019083)2.96424000
98maturation of SSU-rRNA (GO:0030490)2.96108246
99pore complex assembly (GO:0046931)2.93888593
100chromatin assembly or disassembly (GO:0006333)2.93555554
101positive regulation of chromosome segregation (GO:0051984)2.93344646
102snRNA metabolic process (GO:0016073)2.92837501
103cilium organization (GO:0044782)2.91955719
104negative regulation of DNA repair (GO:0045738)2.90768346
105meiotic cell cycle (GO:0051321)2.90754092
106translational termination (GO:0006415)2.90578294
107negative regulation of chromosome segregation (GO:0051985)2.90282831
108spindle assembly checkpoint (GO:0071173)2.90070724
109regulation of chromosome segregation (GO:0051983)2.89353884
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.88156344
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88156344
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88156344
113negative regulation of sister chromatid segregation (GO:0033046)2.88156344
114spindle checkpoint (GO:0031577)2.87846023
115chromosome segregation (GO:0007059)2.86746320
116ribosomal small subunit biogenesis (GO:0042274)2.86527702
117mitotic sister chromatid cohesion (GO:0007064)2.86491134
118cilium assembly (GO:0042384)2.86445197
119regulation of spindle organization (GO:0090224)2.86021483
120double-strand break repair (GO:0006302)2.85043775
121mitotic DNA integrity checkpoint (GO:0044774)2.84896936
122formation of translation preinitiation complex (GO:0001731)2.84505010
123microtubule anchoring (GO:0034453)2.84248445
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84238777
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83647425
126RNA-dependent DNA replication (GO:0006278)2.83459010
127negative regulation of histone methylation (GO:0031061)2.83383322
128mitotic spindle assembly checkpoint (GO:0007094)2.82955834
129telomere maintenance via telomerase (GO:0007004)2.82904649
130centrosome organization (GO:0051297)2.81720836
131histone-serine phosphorylation (GO:0035404)2.81172564
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80722690
133rRNA catabolic process (GO:0016075)2.80719625
134microtubule depolymerization (GO:0007019)2.80347501
135replication fork processing (GO:0031297)2.79562171
136negative regulation of RNA splicing (GO:0033119)2.79270486
137resolution of meiotic recombination intermediates (GO:0000712)2.79064054
138negative regulation of DNA recombination (GO:0045910)2.78235750
139cilium morphogenesis (GO:0060271)2.76299620
140regulation of sister chromatid segregation (GO:0033045)2.75733755
141regulation of mitotic sister chromatid separation (GO:0010965)2.75733755
142regulation of mitotic sister chromatid segregation (GO:0033047)2.75733755
143mitotic spindle checkpoint (GO:0071174)2.75486752
144positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74570952
145somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74395790
146somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74395790
147isotype switching (GO:0045190)2.74395790
148RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72703580
149somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.71115795
150somatic cell DNA recombination (GO:0016444)2.71115795
151neural tube formation (GO:0001841)2.70423164
152microtubule organizing center organization (GO:0031023)2.69469155
153somatic recombination of immunoglobulin gene segments (GO:0016447)2.68947049
154postreplication repair (GO:0006301)2.65624816
155response to X-ray (GO:0010165)2.65359321
156response to pheromone (GO:0019236)2.62913544
157DNA recombination (GO:0006310)2.61684318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.95082217
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43803491
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.59779478
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58641623
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76169711
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65436445
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61323503
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55470088
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55116448
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53782298
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49702633
12FUS_26573619_Chip-Seq_HEK293_Human2.48218324
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40493181
14ZNF274_21170338_ChIP-Seq_K562_Hela2.37243750
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.35789299
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28557184
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26528878
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.21079880
19AR_21909140_ChIP-Seq_LNCAP_Human2.16576974
20TAF15_26573619_Chip-Seq_HEK293_Human2.10499638
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09776668
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08787347
23GBX2_23144817_ChIP-Seq_PC3_Human2.07468325
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06890897
25VDR_23849224_ChIP-Seq_CD4+_Human2.06335361
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.06007264
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03506147
28E2F7_22180533_ChIP-Seq_HELA_Human11.1759565
29VDR_22108803_ChIP-Seq_LS180_Human1.98307542
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.97916933
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97701014
32CIITA_25753668_ChIP-Seq_RAJI_Human1.97050642
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96507136
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96186843
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.95997223
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.94261036
37FOXP3_21729870_ChIP-Seq_TREG_Human1.93146255
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92952568
39XRN2_22483619_ChIP-Seq_HELA_Human1.91016979
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86347648
41IGF1R_20145208_ChIP-Seq_DFB_Human1.85949107
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84628523
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81778907
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79522073
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76593578
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72834780
47TTF2_22483619_ChIP-Seq_HELA_Human1.71211711
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70317063
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68722124
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63511612
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62951828
52DCP1A_22483619_ChIP-Seq_HELA_Human1.62598582
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62069775
54P300_19829295_ChIP-Seq_ESCs_Human1.61371513
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58567294
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58145511
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57029890
58ER_23166858_ChIP-Seq_MCF-7_Human1.56843394
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56833285
60MYC_22102868_ChIP-Seq_BL_Human1.56047685
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54164579
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54124738
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53496960
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53450721
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.52967350
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52436374
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51792135
68ELK1_19687146_ChIP-ChIP_HELA_Human1.50344026
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48030510
70STAT3_23295773_ChIP-Seq_U87_Human1.47998144
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47414052
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47292001
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46674896
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45655725
75GABP_19822575_ChIP-Seq_HepG2_Human1.45497367
76SCL_19346495_ChIP-Seq_HPC-7_Human1.44622874
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40767656
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40291643
79SMAD4_21799915_ChIP-Seq_A2780_Human1.37832806
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.35309300
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34243185
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33525569
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32865841
84KDM5A_27292631_Chip-Seq_BREAST_Human1.31586124
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31230820
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27766595
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.27664913
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.27493451
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26398397
90TCF4_23295773_ChIP-Seq_U87_Human1.25950534
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25865631
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25707728
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25278021
94CBP_20019798_ChIP-Seq_JUKART_Human1.25278021
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24338211
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23283086
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23003507
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.22313088
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21365070
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21151418
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.19534398
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19158732
103VDR_21846776_ChIP-Seq_THP-1_Human1.19151824
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18476556
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18365163
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.17281535
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.17086902
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17007983
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16024348
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14685334
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14469506
112MYC_18940864_ChIP-ChIP_HL60_Human1.13302705
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13208246
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12692350
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.11998610
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10891668
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.10585189
118TCF4_22108803_ChIP-Seq_LS180_Human1.10524302
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09568891
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09001189
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09001189
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07766846
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05552827
124SPI1_23547873_ChIP-Seq_NB4_Human1.05205538
125MYB_26560356_Chip-Seq_TH1_Human1.04863973
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04237217
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02916396
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02513769
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.02238687
130AR_25329375_ChIP-Seq_VCAP_Human1.01889000
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98533075
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98231177
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97679090
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97602846
135CDX2_22108803_ChIP-Seq_LS180_Human0.97358615
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97323980
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97043674
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95500550
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95080709
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94713054
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93795644
142P53_22387025_ChIP-Seq_ESCs_Mouse0.93745402
143TFEB_21752829_ChIP-Seq_HELA_Human0.93575129
144MYB_26560356_Chip-Seq_TH2_Human0.92266422
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92143709
146P300_18555785_Chip-Seq_ESCs_Mouse0.92062511
147TP53_16413492_ChIP-PET_HCT116_Human0.91897105
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91767248
149MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91141715
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90453779
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90277793
152RUNX2_22187159_ChIP-Seq_PCA_Human0.90185582
153BCAT_22108803_ChIP-Seq_LS180_Human0.89853861
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.89603122
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.89388222
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84249311
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83480862
158UTX_26944678_Chip-Seq_JUKART_Human0.81053382
159MAF_26560356_Chip-Seq_TH1_Human0.80771796
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77260991
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76766189
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76675705
163SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74882413
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74225476
165GATA1_22025678_ChIP-Seq_K562_Human0.74038342
166IRF1_19129219_ChIP-ChIP_H3396_Human0.73915863
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73607251
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.72644935
169EWS_26573619_Chip-Seq_HEK293_Human0.70884042
170IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70455262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.12168329
2MP0008057_abnormal_DNA_replication4.79494322
3MP0008877_abnormal_DNA_methylation4.38862279
4MP0003693_abnormal_embryo_hatching4.08487350
5MP0004957_abnormal_blastocyst_morpholog3.94127205
6MP0003111_abnormal_nucleus_morphology3.90302760
7MP0008058_abnormal_DNA_repair3.72558293
8MP0000569_abnormal_digit_pigmentation3.63001222
9MP0003077_abnormal_cell_cycle3.49862867
10MP0002396_abnormal_hematopoietic_system2.99023021
11MP0008007_abnormal_cellular_replicative2.51721803
12MP0003718_maternal_effect2.47435489
13MP0000383_abnormal_hair_follicle2.34554996
14MP0008932_abnormal_embryonic_tissue2.31663162
15MP0003121_genomic_imprinting2.23672888
16MP0000427_abnormal_hair_cycle2.20791779
17MP0009697_abnormal_copulation2.10650269
18MP0010678_abnormal_skin_adnexa2.10531721
19MP0003787_abnormal_imprinting2.05208653
20MP0004808_abnormal_hematopoietic_stem2.05169437
21MP0003763_abnormal_thymus_physiology1.97775040
22MP0003786_premature_aging1.90870430
23MP0003123_paternal_imprinting1.77115618
24MP0000350_abnormal_cell_proliferation1.75169684
25MP0002210_abnormal_sex_determination1.75041393
26MP0001730_embryonic_growth_arrest1.74263639
27MP0005171_absent_coat_pigmentation1.69105147
28MP0003941_abnormal_skin_development1.64589431
29MP0000490_abnormal_crypts_of1.62954710
30MP0003315_abnormal_perineum_morphology1.57217735
31MP0003950_abnormal_plasma_membrane1.55313086
32MP0010352_gastrointestinal_tract_polyps1.54798463
33MP0001929_abnormal_gametogenesis1.49891042
34MP0000703_abnormal_thymus_morphology1.49697941
35MP0005248_abnormal_Harderian_gland1.47838946
36MP0005380_embryogenesis_phenotype1.44765282
37MP0001672_abnormal_embryogenesis/_devel1.44765282
38MP0002009_preneoplasia1.44339826
39MP0005253_abnormal_eye_physiology1.42028470
40MP0001697_abnormal_embryo_size1.39847427
41MP0002398_abnormal_bone_marrow1.38989386
42MP0002019_abnormal_tumor_incidence1.37916049
43MP0001145_abnormal_male_reproductive1.36789842
44MP0002928_abnormal_bile_duct1.34975855
45MP0003984_embryonic_growth_retardation1.33248314
46MP0000313_abnormal_cell_death1.31946665
47MP0002102_abnormal_ear_morphology1.30235190
48MP0002085_abnormal_embryonic_tissue1.29989397
49MP0002084_abnormal_developmental_patter1.29962305
50MP0002088_abnormal_embryonic_growth/wei1.29900646
51MP0005395_other_phenotype1.26613587
52MP0006292_abnormal_olfactory_placode1.26303130
53MP0002080_prenatal_lethality1.25223689
54MP0003122_maternal_imprinting1.25145371
55MP0002233_abnormal_nose_morphology1.24254039
56MP0000653_abnormal_sex_gland1.21609331
57MP0005646_abnormal_pituitary_gland1.19443637
58MP0002086_abnormal_extraembryonic_tissu1.18411040
59MP0005397_hematopoietic_system_phenotyp1.18256881
60MP0001545_abnormal_hematopoietic_system1.18256881
61MP0002722_abnormal_immune_system1.18139045
62MP0000689_abnormal_spleen_morphology1.15728790
63MP0005389_reproductive_system_phenotype1.12572471
64MP0000372_irregular_coat_pigmentation1.12479748
65MP0005551_abnormal_eye_electrophysiolog1.11685508
66MP0002653_abnormal_ependyma_morphology1.10606629
67MP0005671_abnormal_response_to1.08850296
68MP0006054_spinal_hemorrhage1.08642855
69MP0004197_abnormal_fetal_growth/weight/1.07051632
70MP0008995_early_reproductive_senescence1.06056980
71MP0008789_abnormal_olfactory_epithelium1.05997798
72MP0005391_vision/eye_phenotype1.04632796
73MP0001293_anophthalmia1.04349535
74MP0010234_abnormal_vibrissa_follicle1.02396842
75MP0001984_abnormal_olfaction1.02167820
76MP0000631_abnormal_neuroendocrine_gland1.01852178
77MP0010307_abnormal_tumor_latency1.01719116
78MP0001324_abnormal_eye_pigmentation0.99335836
79MP0010030_abnormal_orbit_morphology0.99100167
80MP0003567_abnormal_fetal_cardiomyocyte0.98906180
81MP0001346_abnormal_lacrimal_gland0.98872654
82MP0002638_abnormal_pupillary_reflex0.98682114
83MP0003698_abnormal_male_reproductive0.98636089
84MP0000647_abnormal_sebaceous_gland0.98307297
85MP0002429_abnormal_blood_cell0.97989222
86MP0002938_white_spotting0.97774529
87MP0004133_heterotaxia0.95935425
88MP0005187_abnormal_penis_morphology0.94062482
89MP0000716_abnormal_immune_system0.93985036
90MP0000358_abnormal_cell_content/0.93556278
91MP0002697_abnormal_eye_size0.92981756
92MP0002132_abnormal_respiratory_system0.92194515
93MP0001119_abnormal_female_reproductive0.90482535
94MP0002837_dystrophic_cardiac_calcinosis0.88731627
95MP0002751_abnormal_autonomic_nervous0.85309790
96MP0002095_abnormal_skin_pigmentation0.82475937
97MP0002160_abnormal_reproductive_system0.81919212
98MP0001800_abnormal_humoral_immune0.81600607
99MP0002420_abnormal_adaptive_immunity0.81485274
100MP0003755_abnormal_palate_morphology0.81477460
101MP0002166_altered_tumor_susceptibility0.81093307
102MP0005408_hypopigmentation0.81038951
103MP0003136_yellow_coat_color0.80990475
104MP0000465_gastrointestinal_hemorrhage0.80984634
105MP0004215_abnormal_myocardial_fiber0.80839914
106MP0000015_abnormal_ear_pigmentation0.80385588
107MP0009703_decreased_birth_body0.79770494
108MP0002111_abnormal_tail_morphology0.79402214
109MP0001819_abnormal_immune_cell0.78966316
110MP0002282_abnormal_trachea_morphology0.78064656
111MP0002249_abnormal_larynx_morphology0.76678926
112MP0003195_calcinosis0.76629498
113MP0002234_abnormal_pharynx_morphology0.76075849
114MP0003936_abnormal_reproductive_system0.74862533
115MP0001299_abnormal_eye_distance/0.74350230
116MP0005499_abnormal_olfactory_system0.74333410
117MP0005394_taste/olfaction_phenotype0.74333410
118MP0000685_abnormal_immune_system0.73186760
119MP0000371_diluted_coat_color0.72974657
120MP0005075_abnormal_melanosome_morpholog0.72385485
121MP0001188_hyperpigmentation0.72005317
122MP0000579_abnormal_nail_morphology0.71944443
123MP0001873_stomach_inflammation0.70905243
124MP0002177_abnormal_outer_ear0.69960220
125MP0002006_tumorigenesis0.69584504
126MP0003890_abnormal_embryonic-extraembry0.69505400
127MP0000858_altered_metastatic_potential0.65616992
128MP0003943_abnormal_hepatobiliary_system0.65499081
129MP0002092_abnormal_eye_morphology0.65394461
130MP0000566_synostosis0.65362065
131MP0002452_abnormal_antigen_presenting0.64691664
132MP0003866_abnormal_defecation0.64584574
133MP0009333_abnormal_splenocyte_physiolog0.64225508
134MP0003937_abnormal_limbs/digits/tail_de0.63452006
135MP0002161_abnormal_fertility/fecundity0.63426748
136MP0002723_abnormal_immune_serum0.62389791
137MP0006072_abnormal_retinal_apoptosis0.62375795
138MP0005174_abnormal_tail_pigmentation0.62005313
139MP0001485_abnormal_pinna_reflex0.61734499
140MP0005623_abnormal_meninges_morphology0.59559250
141MP0010368_abnormal_lymphatic_system0.59265332
142MP0000477_abnormal_intestine_morphology0.57242318
143MP0001286_abnormal_eye_development0.57180944
144MP0000470_abnormal_stomach_morphology0.56548724
145MP0004147_increased_porphyrin_level0.56040370
146MP0002075_abnormal_coat/hair_pigmentati0.55427929
147MP0002925_abnormal_cardiovascular_devel0.55060128

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.50058379
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.05931163
3Reticulocytopenia (HP:0001896)3.91909532
4Colon cancer (HP:0003003)3.73250987
5Ependymoma (HP:0002888)3.71003553
6Pancreatic cysts (HP:0001737)3.67738476
7Aplastic anemia (HP:0001915)3.67166035
8Medulloblastoma (HP:0002885)3.65269049
9Pancreatic fibrosis (HP:0100732)3.61731872
10Chronic hepatic failure (HP:0100626)3.52986769
11Supernumerary spleens (HP:0009799)3.49722109
12Tubulointerstitial nephritis (HP:0001970)3.47470546
13Agnosia (HP:0010524)3.43408617
14Duplicated collecting system (HP:0000081)3.38961220
15True hermaphroditism (HP:0010459)3.29239598
16Abnormality of chromosome stability (HP:0003220)3.25423863
17Asplenia (HP:0001746)3.15382820
18Birth length less than 3rd percentile (HP:0003561)3.10842686
19Nephronophthisis (HP:0000090)3.08821822
20Abnormality of the renal collecting system (HP:0004742)3.06780246
21Medial flaring of the eyebrow (HP:0010747)3.03284641
22Abnormality of midbrain morphology (HP:0002418)2.95777683
23Molar tooth sign on MRI (HP:0002419)2.95777683
24Congenital primary aphakia (HP:0007707)2.94584302
25Basal cell carcinoma (HP:0002671)2.83823982
26Abnormality of the renal medulla (HP:0100957)2.81760369
27Aplasia/Hypoplasia of the spleen (HP:0010451)2.79733978
28IgM deficiency (HP:0002850)2.78047548
29Amaurosis fugax (HP:0100576)2.77689874
30Nephroblastoma (Wilms tumor) (HP:0002667)2.75604574
31Myelodysplasia (HP:0002863)2.75468479
32Meckel diverticulum (HP:0002245)2.74320605
33Gait imbalance (HP:0002141)2.71821207
34Abnormality of the preputium (HP:0100587)2.70358140
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.70192874
36Nephrogenic diabetes insipidus (HP:0009806)2.68796495
37Abnormality of the renal cortex (HP:0011035)2.68567802
38Genital tract atresia (HP:0001827)2.67683249
39Selective tooth agenesis (HP:0001592)2.67118690
40Abnormality of the ileum (HP:0001549)2.66038150
41Clubbing of toes (HP:0100760)2.62228976
42Intestinal atresia (HP:0011100)2.62224681
43Abnormality of cells of the erythroid lineage (HP:0012130)2.60021896
44Lymphoma (HP:0002665)2.58724650
45Embryonal renal neoplasm (HP:0011794)2.55587367
46Poor coordination (HP:0002370)2.54994420
47Volvulus (HP:0002580)2.54073321
48Abnormal number of erythroid precursors (HP:0012131)2.53308746
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53091284
50Ectopic kidney (HP:0000086)2.53015164
51Vaginal atresia (HP:0000148)2.53003897
52Rhabdomyosarcoma (HP:0002859)2.51900101
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.51474327
54Abnormal number of incisors (HP:0011064)2.51231702
55Absent radius (HP:0003974)2.49063357
56Oligodactyly (hands) (HP:0001180)2.46905588
57Abnormal lung lobation (HP:0002101)2.46445052
5811 pairs of ribs (HP:0000878)2.46080066
59Cystic liver disease (HP:0006706)2.45657606
60Increased nuchal translucency (HP:0010880)2.45577077
61Postaxial foot polydactyly (HP:0001830)2.44602609
62Proximal placement of thumb (HP:0009623)2.40473567
63Astrocytoma (HP:0009592)2.35276441
64Abnormality of the astrocytes (HP:0100707)2.35276441
65Absent forearm bone (HP:0003953)2.33969576
66Aplasia involving forearm bones (HP:0009822)2.33969576
67Preaxial hand polydactyly (HP:0001177)2.32734813
68Acute myeloid leukemia (HP:0004808)2.32316547
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.31416565
70Pallor (HP:0000980)2.30682778
71Neoplasm of the pancreas (HP:0002894)2.27841487
72Bone marrow hypocellularity (HP:0005528)2.26216741
73Biliary tract neoplasm (HP:0100574)2.26068486
74Renal cortical cysts (HP:0000803)2.25722548
75Impulsivity (HP:0100710)2.25355586
76Premature graying of hair (HP:0002216)2.22178180
77Median cleft lip (HP:0000161)2.22096936
78Abnormality of DNA repair (HP:0003254)2.21834703
79High pitched voice (HP:0001620)2.19258190
80Abnormality of the fingertips (HP:0001211)2.19235199
81Astigmatism (HP:0000483)2.18255259
82Sloping forehead (HP:0000340)2.17969076
83Oral leukoplakia (HP:0002745)2.17272344
84Papillary thyroid carcinoma (HP:0002895)2.16969828
85Pancytopenia (HP:0001876)2.16581775
86Congenital hepatic fibrosis (HP:0002612)2.16473673
87Deviation of the thumb (HP:0009603)2.15620068
88Absent thumb (HP:0009777)2.15418484
89Bile duct proliferation (HP:0001408)2.15257196
90Abnormal biliary tract physiology (HP:0012439)2.15257196
91Tubular atrophy (HP:0000092)2.14901765
92Abnormal ciliary motility (HP:0012262)2.13823003
93Short tibia (HP:0005736)2.10495096
94Patellar aplasia (HP:0006443)2.10356985
95Neoplasm of the oral cavity (HP:0100649)2.10243903
96Small intestinal stenosis (HP:0012848)2.10157381
97Duodenal stenosis (HP:0100867)2.10157381
98Occipital encephalocele (HP:0002085)2.10128049
99Bifid tongue (HP:0010297)2.05177085
100Neoplasm of striated muscle (HP:0009728)2.04713875
101Abnormality of the carotid arteries (HP:0005344)2.02972534
102Prominent nose (HP:0000448)2.01726419
103Neoplasm of the adrenal cortex (HP:0100641)2.01716517
104Postaxial hand polydactyly (HP:0001162)2.01215567
105Renal duplication (HP:0000075)2.01064231
106Degeneration of anterior horn cells (HP:0002398)2.00672374
107Abnormality of the anterior horn cell (HP:0006802)2.00672374
108Thrombocytosis (HP:0001894)2.00196490
109Duplication of thumb phalanx (HP:0009942)1.97212277
110Abnormality of chromosome segregation (HP:0002916)1.97011749
111Oculomotor apraxia (HP:0000657)1.96665410
112Short 4th metacarpal (HP:0010044)1.95987101
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95987101
114Abnormality of the labia minora (HP:0012880)1.94586135
115Abnormality of the pons (HP:0007361)1.92827623
116Rhinitis (HP:0012384)1.91495456
117Abnormal spermatogenesis (HP:0008669)1.91345041
118Abnormal respiratory motile cilium physiology (HP:0012261)1.91308680
119Aplasia/Hypoplasia of the patella (HP:0006498)1.90781411
120Tubulointerstitial abnormality (HP:0001969)1.90706915
121Papilledema (HP:0001085)1.88620521
122Abnormal respiratory epithelium morphology (HP:0012253)1.86621890
123Abnormal respiratory motile cilium morphology (HP:0005938)1.86621890
124Hyperacusis (HP:0010780)1.86480083
125Gaze-evoked nystagmus (HP:0000640)1.85650285
126Furrowed tongue (HP:0000221)1.84823270
127Neoplasm of the colon (HP:0100273)1.84371237
128Glioma (HP:0009733)1.83191828
129Macrocytic anemia (HP:0001972)1.82891160
130Anencephaly (HP:0002323)1.81795362
131Squamous cell carcinoma (HP:0002860)1.81306377
132Tracheoesophageal fistula (HP:0002575)1.81051448
133Gastrointestinal atresia (HP:0002589)1.80939037
134Abnormality of lateral ventricle (HP:0030047)1.79891162
135Broad palm (HP:0001169)1.79868047
136Abnormality of the duodenum (HP:0002246)1.79059413
137Breast hypoplasia (HP:0003187)1.78586433
138Hypoplastic labia majora (HP:0000059)1.78456319
139Oligodactyly (HP:0012165)1.77971462
140Ovarian neoplasm (HP:0100615)1.77379462
141Supernumerary ribs (HP:0005815)1.77335780
142Aganglionic megacolon (HP:0002251)1.77222370
143Rough bone trabeculation (HP:0100670)1.77011232
144Gonadotropin excess (HP:0000837)1.76905345
145Trigonocephaly (HP:0000243)1.75991010
146Missing ribs (HP:0000921)1.75600023
147Broad foot (HP:0001769)1.75263390
148Oligohydramnios (HP:0001562)1.74174388
149Cerebral hypomyelination (HP:0006808)1.73581039
150Cafe-au-lait spot (HP:0000957)1.71386230
151Cellular immunodeficiency (HP:0005374)1.70705441
152Attenuation of retinal blood vessels (HP:0007843)1.69380153
153Prominent nasal bridge (HP:0000426)1.68784034
154Overriding aorta (HP:0002623)1.68497225
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68391048
156Sclerocornea (HP:0000647)1.68334141
157Neoplasm of the rectum (HP:0100743)1.67864922
158Triphalangeal thumb (HP:0001199)1.67583689
159Facial cleft (HP:0002006)1.67407723
160Abdominal situs inversus (HP:0003363)1.67094659
161Abnormality of abdominal situs (HP:0011620)1.67094659
162Dandy-Walker malformation (HP:0001305)1.66801777
163Thyroid carcinoma (HP:0002890)1.66322052
164Small hand (HP:0200055)1.63382721
165Cerebellar dysplasia (HP:0007033)1.63371896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.97548920
2WEE13.97004837
3FRK3.89054172
4ACVR1B3.62035148
5VRK12.92718481
6BMPR1B2.84850678
7NEK22.75571446
8TTK2.75082357
9BUB12.53710821
10PASK2.34587447
11STK102.28634049
12MAP4K22.27789725
13NUAK12.24602360
14MAP4K12.22567913
15SRPK12.20340099
16MKNK12.17579181
17ATR2.06252345
18BRD42.04196757
19PBK1.97700402
20TSSK61.96118592
21STK161.93099733
22WNK31.87372246
23BRSK21.87339657
24EEF2K1.85773671
25LATS11.83183183
26ERBB31.82710898
27PLK11.77776085
28MAP3K41.76249965
29MKNK21.76132723
30AURKB1.70878778
31CDK121.63322195
32STK38L1.62225556
33TRIM281.59099797
34CDK71.58492530
35PLK41.53380568
36STK391.50548057
37RPS6KB21.50468044
38CDK41.35802919
39CHEK21.32714273
40TNIK1.28067990
41BCR1.26250765
42CHEK11.25610648
43TLK11.23546922
44MST41.22855437
45MAPK151.21323389
46TGFBR11.21116247
47RPS6KA41.19643079
48PLK31.19481860
49FGFR21.19323243
50TXK1.19014607
51TAF11.15991579
52CCNB11.15967559
53PNCK1.15123576
54MAP3K81.12856294
55AKT31.11815686
56ATM1.08418183
57CDK61.07817732
58CLK11.04799442
59DYRK31.03722270
60CDK31.00088195
61CDK81.00028262
62PIM10.99214747
63CASK0.98744583
64MELK0.97898203
65FLT30.95383663
66PKN20.93879535
67STK40.92296701
68NEK10.86913092
69CDK20.85128141
70MAPK130.84413856
71PAK40.84357941
72AURKA0.82549823
73CDK90.81584043
74MAP2K70.80445781
75EIF2AK10.79814023
76BRSK10.77718093
77NEK60.77170028
78MAPKAPK30.76907087
79NEK90.76643973
80TRPM70.76343018
81OXSR10.76196817
82RPS6KA50.75731812
83BTK0.75395861
84PIK3CA0.72493403
85FER0.71912627
86CSNK1G30.70204536
87CDK10.67784988
88MET0.67393534
89CSNK1A1L0.66297423
90CSNK2A20.65293952
91JAK30.64293443
92PLK20.63291109
93TEC0.60344198
94PAK20.58647719
95MAP3K60.58472860
96LCK0.57887014
97WNK40.56623088
98CSNK2A10.55979842
99ZAP700.55423795
100KDR0.54182866
101CSNK1G20.52574605
102CSNK1D0.52227111
103STK30.50420130
104ITK0.49840372
105ERBB20.49473491
106NLK0.49095499
107MAP3K100.47862842
108EIF2AK20.47458230
109ADRBK20.47385662
110MAPKAPK50.46715533
111CAMK1G0.46371104
112TGFBR20.45807660
113CSNK1G10.45484438
114TAOK30.44940053
115LRRK20.42676259
116PRKDC0.42673369
117RPS6KB10.41370734
118VRK20.40829625
119ALK0.39005271
120ZAK0.38887931
121YES10.38866604
122TAOK20.38669075
123PDK40.38330893
124PDK30.38330893
125PRKCE0.37669907
126KIT0.37125543
127CSNK1E0.37112558
128MAPK140.36836977
129FGFR10.36817510
130OBSCN0.36052309
131PAK30.36004944
132MST1R0.35587757
133GRK10.35239200
134PDK20.34621521
135EIF2AK30.33874077
136INSRR0.33076883
137DAPK10.32384277
138STK240.29301615
139CSF1R0.27911043
140MAPK10.27073379

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.22640676
2Mismatch repair_Homo sapiens_hsa034304.80405393
3Homologous recombination_Homo sapiens_hsa034403.67724870
4Spliceosome_Homo sapiens_hsa030403.25429224
5Base excision repair_Homo sapiens_hsa034103.24075679
6Non-homologous end-joining_Homo sapiens_hsa034503.15529224
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12135719
8Nucleotide excision repair_Homo sapiens_hsa034203.08977987
9Fanconi anemia pathway_Homo sapiens_hsa034602.82660167
10Cell cycle_Homo sapiens_hsa041102.72148544
11Ribosome_Homo sapiens_hsa030102.63626857
12RNA transport_Homo sapiens_hsa030132.63039316
13RNA polymerase_Homo sapiens_hsa030202.41553576
14Basal transcription factors_Homo sapiens_hsa030222.31329317
15Propanoate metabolism_Homo sapiens_hsa006402.18337310
16RNA degradation_Homo sapiens_hsa030182.05765269
17Pyrimidine metabolism_Homo sapiens_hsa002402.00801899
18mRNA surveillance pathway_Homo sapiens_hsa030151.96014596
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90989145
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85959078
21One carbon pool by folate_Homo sapiens_hsa006701.76164018
22Nitrogen metabolism_Homo sapiens_hsa009101.64538682
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61308496
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50821832
25Proteasome_Homo sapiens_hsa030501.46069118
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46034732
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44496215
28Selenocompound metabolism_Homo sapiens_hsa004501.43411378
29p53 signaling pathway_Homo sapiens_hsa041151.39477506
30Butanoate metabolism_Homo sapiens_hsa006501.38671615
31Circadian rhythm_Homo sapiens_hsa047101.35051622
32Primary immunodeficiency_Homo sapiens_hsa053401.32292308
33Antigen processing and presentation_Homo sapiens_hsa046121.27388092
34Herpes simplex infection_Homo sapiens_hsa051681.25068388
35Purine metabolism_Homo sapiens_hsa002301.19115599
36Oocyte meiosis_Homo sapiens_hsa041141.15638507
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15612231
38HTLV-I infection_Homo sapiens_hsa051661.07122322
39Epstein-Barr virus infection_Homo sapiens_hsa051691.06063187
40Steroid biosynthesis_Homo sapiens_hsa001001.04779246
41Viral carcinogenesis_Homo sapiens_hsa052031.03856966
42Regulation of autophagy_Homo sapiens_hsa041401.00145264
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98966649
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.91984069
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90578094
46ABC transporters_Homo sapiens_hsa020100.89970414
47Fatty acid elongation_Homo sapiens_hsa000620.88067316
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86992069
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86707205
50Peroxisome_Homo sapiens_hsa041460.85405472
51Tryptophan metabolism_Homo sapiens_hsa003800.82781079
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82732166
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81693055
54Thyroid cancer_Homo sapiens_hsa052160.81122993
55Systemic lupus erythematosus_Homo sapiens_hsa053220.80496204
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78479243
57Small cell lung cancer_Homo sapiens_hsa052220.77223331
58Protein export_Homo sapiens_hsa030600.72001026
59MicroRNAs in cancer_Homo sapiens_hsa052060.68700389
60Basal cell carcinoma_Homo sapiens_hsa052170.66266797
61Caffeine metabolism_Homo sapiens_hsa002320.64908442
62Colorectal cancer_Homo sapiens_hsa052100.64489558
63Taste transduction_Homo sapiens_hsa047420.62984290
64Linoleic acid metabolism_Homo sapiens_hsa005910.62887278
65T cell receptor signaling pathway_Homo sapiens_hsa046600.61974070
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61775972
67Hematopoietic cell lineage_Homo sapiens_hsa046400.61511554
68B cell receptor signaling pathway_Homo sapiens_hsa046620.60643238
69Measles_Homo sapiens_hsa051620.59728980
70Notch signaling pathway_Homo sapiens_hsa043300.59477620
71beta-Alanine metabolism_Homo sapiens_hsa004100.57431541
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.57057119
73Fatty acid metabolism_Homo sapiens_hsa012120.56325107
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.56246472
75Hepatitis B_Homo sapiens_hsa051610.54328411
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52181314
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51277374
78Pyruvate metabolism_Homo sapiens_hsa006200.51237654
79Prostate cancer_Homo sapiens_hsa052150.50055903
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50047643
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.49107299
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47641019
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47106430
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46695537
85Wnt signaling pathway_Homo sapiens_hsa043100.46305174
86TGF-beta signaling pathway_Homo sapiens_hsa043500.46132852
87Pancreatic cancer_Homo sapiens_hsa052120.46013815
88Pathways in cancer_Homo sapiens_hsa052000.45697927
89Hippo signaling pathway_Homo sapiens_hsa043900.43728544
90Alcoholism_Homo sapiens_hsa050340.43676153
91Metabolic pathways_Homo sapiens_hsa011000.42520479
92Hedgehog signaling pathway_Homo sapiens_hsa043400.42010585
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41610315
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41037870
95Chronic myeloid leukemia_Homo sapiens_hsa052200.40707706
96Non-small cell lung cancer_Homo sapiens_hsa052230.40301361
97Acute myeloid leukemia_Homo sapiens_hsa052210.39483717
98N-Glycan biosynthesis_Homo sapiens_hsa005100.38560817
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.38196961
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35968440
101Dorso-ventral axis formation_Homo sapiens_hsa043200.33241406
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33049741
103Inositol phosphate metabolism_Homo sapiens_hsa005620.32832226
104Chemical carcinogenesis_Homo sapiens_hsa052040.31877073
105Glutathione metabolism_Homo sapiens_hsa004800.31340190
106Folate biosynthesis_Homo sapiens_hsa007900.31340025
107Apoptosis_Homo sapiens_hsa042100.31246504
108Fatty acid degradation_Homo sapiens_hsa000710.31117266
109Glycerolipid metabolism_Homo sapiens_hsa005610.30926195
110Fatty acid biosynthesis_Homo sapiens_hsa000610.30354594
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29959251
112Viral myocarditis_Homo sapiens_hsa054160.29165380
113Ether lipid metabolism_Homo sapiens_hsa005650.28598012
114Adherens junction_Homo sapiens_hsa045200.28143069
115Olfactory transduction_Homo sapiens_hsa047400.27556330
116Phototransduction_Homo sapiens_hsa047440.27424083
117Influenza A_Homo sapiens_hsa051640.27236412
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26944593
119FoxO signaling pathway_Homo sapiens_hsa040680.26344643
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25493573
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25181031
122Vitamin digestion and absorption_Homo sapiens_hsa049770.24926199
123Lysine degradation_Homo sapiens_hsa003100.24855273
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24832707
125Bladder cancer_Homo sapiens_hsa052190.24706116
126Shigellosis_Homo sapiens_hsa051310.23736150
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.23048173
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22879056
129Platelet activation_Homo sapiens_hsa046110.22093004
130Renin-angiotensin system_Homo sapiens_hsa046140.20003129
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19571382
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18855784
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.18807203
134Sphingolipid metabolism_Homo sapiens_hsa006000.18092401
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.17310363
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17175334
137Leishmaniasis_Homo sapiens_hsa051400.17038029
138Tight junction_Homo sapiens_hsa045300.16926600
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16583356
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15065826
141Legionellosis_Homo sapiens_hsa051340.14482992
142Hepatitis C_Homo sapiens_hsa051600.13187509
143Huntingtons disease_Homo sapiens_hsa050160.13177734
144Toxoplasmosis_Homo sapiens_hsa051450.13071786
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12905280
146Arachidonic acid metabolism_Homo sapiens_hsa005900.12549276
147Endometrial cancer_Homo sapiens_hsa052130.12426863
148Proteoglycans in cancer_Homo sapiens_hsa052050.12312684

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