SPIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.19520295
2attachment of spindle microtubules to kinetochore (GO:0008608)6.89379887
3mitotic metaphase plate congression (GO:0007080)6.49777485
4regulation of female gonad development (GO:2000194)6.00787988
5female gamete generation (GO:0007292)5.70147796
6maturation of 5.8S rRNA (GO:0000460)5.47530218
7metaphase plate congression (GO:0051310)5.44206404
8regulation of meiosis (GO:0040020)5.33531003
9male meiosis (GO:0007140)5.23576485
10mitotic chromosome condensation (GO:0007076)5.18585714
11negative regulation of meiosis (GO:0045835)5.15103757
12histone H2A monoubiquitination (GO:0035518)5.12476667
13establishment of chromosome localization (GO:0051303)5.11726760
14DNA methylation involved in gamete generation (GO:0043046)4.89013353
15mitotic sister chromatid segregation (GO:0000070)4.81208471
16DNA damage induced protein phosphorylation (GO:0006975)4.72161504
17regulation of DNA methylation (GO:0044030)4.71414862
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.69524809
19oocyte maturation (GO:0001556)4.63149840
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.58614040
21negative regulation of hormone metabolic process (GO:0032351)4.55882045
22negative regulation of hormone biosynthetic process (GO:0032353)4.55882045
23regulation of meiosis I (GO:0060631)4.50344739
24* meiotic cell cycle (GO:0051321)4.48484041
25regulation of sister chromatid cohesion (GO:0007063)4.40863888
26meiotic chromosome segregation (GO:0045132)4.36190195
27regulation of meiotic cell cycle (GO:0051445)4.22516742
28histone H2A ubiquitination (GO:0033522)4.15143531
29CENP-A containing nucleosome assembly (GO:0034080)4.08087638
30chromosome segregation (GO:0007059)4.07432128
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.05314450
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.05314450
33positive regulation of mitotic sister chromatid separation (GO:1901970)4.05314450
34regulation of exit from mitosis (GO:0007096)4.04738323
35monoubiquitinated protein deubiquitination (GO:0035520)4.02814328
36glycerophospholipid catabolic process (GO:0046475)4.00258215
37protein localization to kinetochore (GO:0034501)3.94367847
38sister chromatid segregation (GO:0000819)3.93765503
39negative regulation of meiotic cell cycle (GO:0051447)3.90983210
40chromatin remodeling at centromere (GO:0031055)3.87396605
41positive regulation of chromosome segregation (GO:0051984)3.86404287
42regulation of spindle organization (GO:0090224)3.79890288
43female gonad development (GO:0008585)3.76970758
44regulation of transforming growth factor beta2 production (GO:0032909)3.74146298
45kinetochore assembly (GO:0051382)3.73699493
46protein localization to chromosome (GO:0034502)3.71245089
47DNA replication-independent nucleosome assembly (GO:0006336)3.68871010
48DNA replication-independent nucleosome organization (GO:0034724)3.68871010
49notochord development (GO:0030903)3.66683470
50regulation of retinoic acid receptor signaling pathway (GO:0048385)3.65595592
51presynaptic membrane assembly (GO:0097105)3.64840517
52regulation of mitotic spindle organization (GO:0060236)3.63743922
53protein localization to chromosome, centromeric region (GO:0071459)3.63642707
54histone exchange (GO:0043486)3.63561055
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.61195723
56myoblast migration (GO:0051451)3.59991359
57spindle checkpoint (GO:0031577)3.58947048
58snRNA transcription (GO:0009301)3.57578034
59kinetochore organization (GO:0051383)3.51533817
60paraxial mesoderm development (GO:0048339)3.49891241
61DNA methylation (GO:0006306)3.49785535
62DNA alkylation (GO:0006305)3.49785535
63negative regulation of smooth muscle cell differentiation (GO:0051151)3.43112298
64regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41498022
65glutamate secretion (GO:0014047)3.41061559
66vocalization behavior (GO:0071625)3.40267041
67DNA replication checkpoint (GO:0000076)3.40250503
68neuron cell-cell adhesion (GO:0007158)3.39433834
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.38171733
70microtubule severing (GO:0051013)3.36372698
71regulation of chromosome segregation (GO:0051983)3.35434710
72microtubule anchoring (GO:0034453)3.34415709
73pyrimidine nucleobase catabolic process (GO:0006208)3.32320847
74cytoskeleton-dependent cytokinesis (GO:0061640)3.30920848
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29807973
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.29432091
77regulation of glucocorticoid metabolic process (GO:0031943)3.25442028
78regulation of histone H3-K27 methylation (GO:0061085)3.25388819
79microtubule nucleation (GO:0007020)3.25369464
80presynaptic membrane organization (GO:0097090)3.24596914
81sister chromatid cohesion (GO:0007062)3.23731461
82oogenesis (GO:0048477)3.20433504
83protein K6-linked ubiquitination (GO:0085020)3.20390716
84positive regulation of megakaryocyte differentiation (GO:0045654)3.20320207
85microtubule depolymerization (GO:0007019)3.20120440
86gene silencing by RNA (GO:0031047)3.19836378
87positive regulation of DNA-dependent DNA replication (GO:2000105)3.19571162
88negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17902922
89negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.17902922
90mitotic nuclear envelope disassembly (GO:0007077)3.16590303
91negative regulation of cell division (GO:0051782)3.16498052
92negative regulation of nuclear division (GO:0051784)3.14959216
93mitotic spindle checkpoint (GO:0071174)3.14564498
94DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.13961361
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.13593216
96meiotic nuclear division (GO:0007126)3.08713063
97type B pancreatic cell development (GO:0003323)3.08486174
98synaptic vesicle maturation (GO:0016188)3.08094403
99DNA damage response, signal transduction resulting in transcription (GO:0042772)3.07628328
100layer formation in cerebral cortex (GO:0021819)3.06898014
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06700269
102interkinetic nuclear migration (GO:0022027)3.06255436
103regulation of mitotic sister chromatid separation (GO:0010965)3.05844205
104regulation of mitotic sister chromatid segregation (GO:0033047)3.05844205
105regulation of sister chromatid segregation (GO:0033045)3.05844205
106regulation of mitotic spindle checkpoint (GO:1903504)3.03592084
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03592084
108membrane disassembly (GO:0030397)3.00571779
109nuclear envelope disassembly (GO:0051081)3.00571779
110chaperone-mediated protein transport (GO:0072321)2.97588490
111meiotic cell cycle process (GO:1903046)2.96442980
112postsynaptic membrane organization (GO:0001941)2.96130513
113neuron recognition (GO:0008038)2.95827520
114apical protein localization (GO:0045176)2.95724554
115axonal fasciculation (GO:0007413)2.95553996
116parturition (GO:0007567)2.95253368
117regulation of synaptic vesicle exocytosis (GO:2000300)2.94524072
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76705999
119ionotropic glutamate receptor signaling pathway (GO:0035235)2.71681621
120nucleobase catabolic process (GO:0046113)2.70099656
121axon extension (GO:0048675)2.68809665
122cell migration in hindbrain (GO:0021535)2.67493607
123protein localization to synapse (GO:0035418)2.64625858
124gamma-aminobutyric acid transport (GO:0015812)2.62865524
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61683715
126dendrite morphogenesis (GO:0048813)2.57187494
127regulation of neuronal synaptic plasticity (GO:0048168)2.51120483
128establishment of mitochondrion localization (GO:0051654)2.50227021
129neurotransmitter secretion (GO:0007269)2.50071740
130synaptic vesicle exocytosis (GO:0016079)2.47944737
131cell communication by electrical coupling (GO:0010644)2.46894424
132positive regulation of synapse assembly (GO:0051965)2.45001268
133regulation of synaptic vesicle transport (GO:1902803)2.44782844
134neuron projection extension (GO:1990138)2.44708532
135asymmetric protein localization (GO:0008105)2.42377419
136innervation (GO:0060384)2.39903694
137cerebellar granule cell differentiation (GO:0021707)2.39521661
138embryonic foregut morphogenesis (GO:0048617)2.39234077
139sodium ion export (GO:0071436)2.37255398
140glutamate receptor signaling pathway (GO:0007215)2.36833696
141exploration behavior (GO:0035640)2.36092916
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35649085
143central nervous system projection neuron axonogenesis (GO:0021952)2.33919900
144regulation of dendritic spine morphogenesis (GO:0061001)2.31973133
145regulation of synapse assembly (GO:0051963)2.31070723
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29956676
147negative regulation of dendrite morphogenesis (GO:0050774)2.27774162
148cellular potassium ion homeostasis (GO:0030007)2.27564205
149cochlea development (GO:0090102)2.25860231
150dendritic spine morphogenesis (GO:0060997)2.25726831
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25657354
152membrane assembly (GO:0071709)2.25276981
153developmental cell growth (GO:0048588)2.23177099
154synaptic vesicle endocytosis (GO:0048488)2.22692048
155negative regulation of oligodendrocyte differentiation (GO:0048715)2.21398033
156neurotransmitter-gated ion channel clustering (GO:0072578)2.20795309
157negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.20513441
158mating behavior (GO:0007617)2.17699008
159ephrin receptor signaling pathway (GO:0048013)2.17535279
160anterior/posterior axis specification, embryo (GO:0008595)2.16657683
161mitotic sister chromatid cohesion (GO:0007064)2.16317600
162regulation of axon guidance (GO:1902667)2.16106685
163synapse assembly (GO:0007416)2.15595378
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.14468431
165lung-associated mesenchyme development (GO:0060484)2.13852493
166synaptic transmission, glutamatergic (GO:0035249)2.13563142
167dendritic spine organization (GO:0097061)2.13013538
168positive regulation of dendritic spine development (GO:0060999)2.12712487
169cell communication involved in cardiac conduction (GO:0086065)2.12441567
170regulation of Rac protein signal transduction (GO:0035020)2.12255680
171regulation of cAMP-dependent protein kinase activity (GO:2000479)2.11965027
172generation of neurons (GO:0048699)2.11869382
173establishment of nucleus localization (GO:0040023)2.11816665
174neuron projection extension involved in neuron projection guidance (GO:1902284)2.11732157
175axon extension involved in axon guidance (GO:0048846)2.11732157
176suckling behavior (GO:0001967)2.09346023
177regulation of cell fate specification (GO:0042659)2.08707666
178positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.08664466
179hippo signaling (GO:0035329)2.08375210
180gastrulation with mouth forming second (GO:0001702)2.05627698
181regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.05450561
182inner ear receptor cell development (GO:0060119)2.05446834
183cerebral cortex radially oriented cell migration (GO:0021799)2.04964261
184cytoskeletal anchoring at plasma membrane (GO:0007016)2.04784209
185neuron-neuron synaptic transmission (GO:0007270)2.03484258
186positive regulation of synapse maturation (GO:0090129)2.02841134
187locomotory exploration behavior (GO:0035641)2.02671891
188synapse organization (GO:0050808)2.02303699
189auditory behavior (GO:0031223)2.01548243
190cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.01514864
191organelle transport along microtubule (GO:0072384)2.01473673
192epithelial cell differentiation involved in kidney development (GO:0035850)2.00616909
193hippocampus development (GO:0021766)1.99984706
194regulation of axon extension involved in axon guidance (GO:0048841)1.99614314
195negative regulation of dendrite development (GO:2000171)1.98898600
196regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.98712578
197Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.97913392
198amino acid import (GO:0043090)1.97109339
199convergent extension (GO:0060026)1.95871032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.25874824
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.80198750
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.66471357
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01188320
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.96372058
6E2F7_22180533_ChIP-Seq_HELA_Human2.91483698
7KAP1_22055183_ChIP-Seq_ESCs_Mouse2.82447397
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60017438
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59941870
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55117888
11AR_21909140_ChIP-Seq_LNCAP_Human2.48027258
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38558740
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30873404
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29371811
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25002088
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.18351398
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.16250726
18GBX2_23144817_ChIP-Seq_PC3_Human2.10656385
19FUS_26573619_Chip-Seq_HEK293_Human2.04049561
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02582158
21IGF1R_20145208_ChIP-Seq_DFB_Human2.02553476
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.99808852
23RNF2_27304074_Chip-Seq_NSC_Mouse1.95761000
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92891222
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.92796403
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89585697
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84651621
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84150433
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.82061139
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.77537898
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73718963
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73444572
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73444572
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72455521
35EZH2_22144423_ChIP-Seq_EOC_Human1.70888095
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70444296
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68507288
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68339466
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64843597
40EWS_26573619_Chip-Seq_HEK293_Human1.64752935
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64727499
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63650804
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61582496
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57873158
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57589072
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.57419161
47* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56768050
48STAT3_23295773_ChIP-Seq_U87_Human1.56443771
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55503366
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50674956
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49495229
52* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.49355441
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.48977965
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.48600337
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.47070531
56RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46433592
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45884826
58TAF15_26573619_Chip-Seq_HEK293_Human1.45229236
59SMAD4_21799915_ChIP-Seq_A2780_Human1.44892457
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.43983984
61REST_21632747_ChIP-Seq_MESCs_Mouse1.43852649
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43620948
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.41748424
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41197557
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.40755617
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39277043
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39012569
68TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37498946
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36932660
70TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36679813
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36339021
72* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35861079
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34494223
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34346773
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.33475967
76* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32100584
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31351856
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30622088
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30548085
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28351814
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28067355
82SOX9_26525672_Chip-Seq_HEART_Mouse1.27241680
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25367793
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25367793
85VDR_22108803_ChIP-Seq_LS180_Human1.25350233
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24857710
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24505963
88* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24184569
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24080895
90P300_19829295_ChIP-Seq_ESCs_Human1.23758560
91MYC_18940864_ChIP-ChIP_HL60_Human1.22159775
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21564825
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21219654
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.21118789
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.18458924
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17073798
97* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17066640
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16845987
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16223898
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.16122465
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15860289
102KDM2B_26808549_Chip-Seq_REH_Human1.15109847
103CDX2_22108803_ChIP-Seq_LS180_Human1.15048535
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14844732
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14761938
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.14296076
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.13896498
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.13142265
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.12738819
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.11775687
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.11677986
112JUN_21703547_ChIP-Seq_K562_Human1.11163421
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10713274
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10713274
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10269561
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.09662703
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.09211385
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08780789
119* STAT1_17558387_ChIP-Seq_HELA_Human1.08547036
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08363951
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08249489
122AHR_22903824_ChIP-Seq_MCF-7_Human1.08025572
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.07662926
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07464161
125TCF4_23295773_ChIP-Seq_U87_Human1.07130144
126AR_25329375_ChIP-Seq_VCAP_Human1.07073059
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.06937829
128GF1B_26923725_Chip-Seq_HPCs_Mouse1.06847465
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06538568
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.06326299
131NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05590090
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.05460270
133ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05224758
134* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04622377
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04087939
136MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03927011
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.03727824
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03514197
139RING1B_27294783_Chip-Seq_ESCs_Mouse1.02365543
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.01936468
141AR_21572438_ChIP-Seq_LNCaP_Human1.01833523
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01788926
143TP53_18474530_ChIP-ChIP_U2OS_Human1.01716144
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01606758
145WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01605770
146CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01583604
147CMYC_18555785_Chip-Seq_ESCs_Mouse1.01407580
148NMYC_18555785_Chip-Seq_ESCs_Mouse1.00822181
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00033447
150* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99904964
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98645777
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.98522848
153CTCF_18555785_Chip-Seq_ESCs_Mouse0.97637421
154PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96324367
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95771147
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.95659737
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94288545
158P53_22387025_ChIP-Seq_ESCs_Mouse0.94093103
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93731831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.21500348
2MP0008877_abnormal_DNA_methylation4.51964584
3MP0003787_abnormal_imprinting4.47738769
4MP0005451_abnormal_body_composition4.33782096
5MP0002102_abnormal_ear_morphology4.10028638
6MP0003646_muscle_fatigue3.59566166
7MP0003693_abnormal_embryo_hatching3.35561180
8MP0010094_abnormal_chromosome_stability3.08286813
9MP0003121_genomic_imprinting2.95988614
10MP0002653_abnormal_ependyma_morphology2.74630820
11MP0003123_paternal_imprinting2.67450553
12MP0001119_abnormal_female_reproductive2.60840598
13MP0003077_abnormal_cell_cycle2.60330092
14MP0003111_abnormal_nucleus_morphology2.40156388
15MP0003699_abnormal_female_reproductive2.36466865
16MP0005395_other_phenotype2.30311605
17MP0005408_hypopigmentation2.26946037
18MP0006292_abnormal_olfactory_placode2.15882059
19MP0005646_abnormal_pituitary_gland2.15290862
20MP0004957_abnormal_blastocyst_morpholog2.09054351
21MP0000778_abnormal_nervous_system2.07940201
22MP0001929_abnormal_gametogenesis2.05821857
23MP0000653_abnormal_sex_gland2.04078309
24MP0002210_abnormal_sex_determination1.99655009
25MP0002249_abnormal_larynx_morphology1.98801490
26MP0003635_abnormal_synaptic_transmissio1.97509512
27MP0003937_abnormal_limbs/digits/tail_de1.92954701
28MP0003122_maternal_imprinting1.92039230
29MP0003941_abnormal_skin_development1.82401265
30MP0001299_abnormal_eye_distance/1.71965360
31MP0008932_abnormal_embryonic_tissue1.69370378
32MP0000537_abnormal_urethra_morphology1.68104524
33MP0008007_abnormal_cellular_replicative1.66801514
34MP0003315_abnormal_perineum_morphology1.65945497
35MP0009780_abnormal_chondrocyte_physiolo1.64885088
36MP0000579_abnormal_nail_morphology1.62070459
37MP0001529_abnormal_vocalization1.60696871
38MP0001177_atelectasis1.56530147
39MP0005423_abnormal_somatic_nervous1.51422382
40MP0008438_abnormal_cutaneous_collagen1.49138903
41MP0004270_analgesia1.49018301
42MP0005257_abnormal_intraocular_pressure1.46150723
43MP0005623_abnormal_meninges_morphology1.40824985
44MP0001145_abnormal_male_reproductive1.40675799
45MP0009697_abnormal_copulation1.40656610
46MP0001905_abnormal_dopamine_level1.37699720
47MP0002161_abnormal_fertility/fecundity1.37083028
48MP0003705_abnormal_hypodermis_morpholog1.35163305
49MP0004264_abnormal_extraembryonic_tissu1.30886106
50MP0009745_abnormal_behavioral_response1.30456938
51MP0002572_abnormal_emotion/affect_behav1.30424887
52MP0010368_abnormal_lymphatic_system1.29755670
53MP0003119_abnormal_digestive_system1.28613200
54MP0002085_abnormal_embryonic_tissue1.27559356
55MP0002697_abnormal_eye_size1.26612408
56MP0000350_abnormal_cell_proliferation1.25882622
57MP0003283_abnormal_digestive_organ1.24396556
58MP0001486_abnormal_startle_reflex1.24319587
59MP0003890_abnormal_embryonic-extraembry1.23632700
60MP0002064_seizures1.23451401
61MP0003755_abnormal_palate_morphology1.21966029
62MP0008058_abnormal_DNA_repair1.21698615
63MP0005503_abnormal_tendon_morphology1.20956699
64MP0000639_abnormal_adrenal_gland1.20021256
65MP0000955_abnormal_spinal_cord1.19510723
66MP0002272_abnormal_nervous_system1.19075723
67MP0004811_abnormal_neuron_physiology1.17513717
68MP0002735_abnormal_chemical_nociception1.16229736
69MP0010352_gastrointestinal_tract_polyps1.15929004
70MP0005275_abnormal_skin_tensile1.15391398
71MP0002822_catalepsy1.14799038
72MP0009672_abnormal_birth_weight1.13029119
73MP0001697_abnormal_embryo_size1.11691247
74MP0010030_abnormal_orbit_morphology1.11204140
75MP0000049_abnormal_middle_ear1.10072372
76MP0000566_synostosis1.07190572
77MP0004272_abnormal_basement_membrane1.06016548
78MP0010386_abnormal_urinary_bladder1.05916818
79MP0009250_abnormal_appendicular_skeleto1.05761635
80MP0000762_abnormal_tongue_morphology1.05600099
81MP0002084_abnormal_developmental_patter1.04204072
82MP0002734_abnormal_mechanical_nocicepti1.04082550
83MP0002152_abnormal_brain_morphology1.02455970
84MP0009703_decreased_birth_body1.01688511
85MP0003115_abnormal_respiratory_system1.01216583
86MP0009046_muscle_twitch1.00658395
87MP0000428_abnormal_craniofacial_morphol0.99691727
88MP0002882_abnormal_neuron_morphology0.99579820
89MP0002736_abnormal_nociception_after0.99560425
90MP0004859_abnormal_synaptic_plasticity0.96949398
91MP0001730_embryonic_growth_arrest0.96672877
92MP0005380_embryogenesis_phenotype0.96643237
93MP0001672_abnormal_embryogenesis/_devel0.96643237
94MP0010234_abnormal_vibrissa_follicle0.95779531
95MP0001293_anophthalmia0.95611693
96MP0002751_abnormal_autonomic_nervous0.95023986
97MP0002081_perinatal_lethality0.94802895
98MP0008057_abnormal_DNA_replication0.94609436
99MP0003698_abnormal_male_reproductive0.94605103
100MP0002234_abnormal_pharynx_morphology0.94098416
101MP0002557_abnormal_social/conspecific_i0.94015431
102MP0004885_abnormal_endolymph0.93190617
103MP0001915_intracranial_hemorrhage0.92344797
104MP0002877_abnormal_melanocyte_morpholog0.92158305
105MP0001286_abnormal_eye_development0.92095532
106MP0010678_abnormal_skin_adnexa0.91877124
107MP0005409_darkened_coat_color0.91473884
108MP0008789_abnormal_olfactory_epithelium0.91427224
109MP0005187_abnormal_penis_morphology0.90828196
110MP0000383_abnormal_hair_follicle0.90556624
111MP0001919_abnormal_reproductive_system0.90105004
112MP0004145_abnormal_muscle_electrophysio0.87052497
113MP0004133_heterotaxia0.86845199
114MP0006276_abnormal_autonomic_nervous0.86311137
115MP0005389_reproductive_system_phenotype0.85528349
116MP0005310_abnormal_salivary_gland0.85281143
117MP0003567_abnormal_fetal_cardiomyocyte0.85087636
118MP0000013_abnormal_adipose_tissue0.84344897
119MP0000631_abnormal_neuroendocrine_gland0.84291135
120MP0009384_cardiac_valve_regurgitation0.82885090
121MP0003861_abnormal_nervous_system0.81891367
122MP0000462_abnormal_digestive_system0.81854616
123MP0009053_abnormal_anal_canal0.81657386
124MP0002092_abnormal_eye_morphology0.80913840
125MP0002177_abnormal_outer_ear0.80456258
126MP0002066_abnormal_motor_capabilities/c0.77688352
127MP0002067_abnormal_sensory_capabilities0.76780084
128MP0003938_abnormal_ear_development0.76071645
129MP0002116_abnormal_craniofacial_bone0.75962213
130MP0001440_abnormal_grooming_behavior0.75531524
131MP0000427_abnormal_hair_cycle0.74984411
132MP0002160_abnormal_reproductive_system0.74799873
133MP0005394_taste/olfaction_phenotype0.74796318
134MP0005499_abnormal_olfactory_system0.74796318
135MP0002233_abnormal_nose_morphology0.74321677
136MP0003880_abnormal_central_pattern0.73284642
137MP0003385_abnormal_body_wall0.71326635
138MP0003984_embryonic_growth_retardation0.69375613
139MP0002019_abnormal_tumor_incidence0.67456752
140MP0000432_abnormal_head_morphology0.66915934
141MP0004782_abnormal_surfactant_physiolog0.66798764
142MP0003950_abnormal_plasma_membrane0.66536981
143MP0002088_abnormal_embryonic_growth/wei0.65160770
144MP0002109_abnormal_limb_morphology0.64837595
145MP0005647_abnormal_sex_gland0.64740491
146MP0000678_abnormal_parathyroid_gland0.64402255
147MP0001968_abnormal_touch/_nociception0.64287860
148MP0003935_abnormal_craniofacial_develop0.62131318
149MP0003942_abnormal_urinary_system0.61242526
150MP0005248_abnormal_Harderian_gland0.60945586
151MP0001188_hyperpigmentation0.60412021
152MP0000534_abnormal_ureter_morphology0.58277853
153MP0008260_abnormal_autophagy0.58102888
154MP0002932_abnormal_joint_morphology0.57827132
155MP0005621_abnormal_cell_physiology0.56649240
156MP0001984_abnormal_olfaction0.56231587
157MP0002114_abnormal_axial_skeleton0.55775392
158MP0002063_abnormal_learning/memory/cond0.55680380
159MP0004484_altered_response_of0.54718238
160MP0002184_abnormal_innervation0.54700849

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.71449289
2Papillary thyroid carcinoma (HP:0002895)6.87820721
3Abnormality of the labia minora (HP:0012880)5.16046618
4Chromsome breakage (HP:0040012)4.67149356
5Birth length less than 3rd percentile (HP:0003561)4.25166197
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24732895
7Cortical dysplasia (HP:0002539)4.22846310
8Thyroid carcinoma (HP:0002890)4.18101669
9Shawl scrotum (HP:0000049)3.96076104
10Patellar aplasia (HP:0006443)3.89583644
11Facial hemangioma (HP:0000329)3.81291860
12Adrenal hypoplasia (HP:0000835)3.57741153
13Aplasia/Hypoplasia of the patella (HP:0006498)3.57507915
14Breast hypoplasia (HP:0003187)3.46368252
15Capillary hemangiomas (HP:0005306)3.25347953
16Flat capital femoral epiphysis (HP:0003370)3.24598849
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12687747
18Abnormality of chromosome segregation (HP:0002916)3.04757254
19Supernumerary spleens (HP:0009799)2.78999195
20Infertility (HP:0000789)2.78931897
21Acute myeloid leukemia (HP:0004808)2.72878647
22Focal motor seizures (HP:0011153)2.69878218
23Abnormality of lateral ventricle (HP:0030047)2.68846203
24Breast aplasia (HP:0100783)2.67836493
25Abnormality of the lower motor neuron (HP:0002366)2.64954145
26Abnormality of the fingertips (HP:0001211)2.64533657
27Abnormality of chromosome stability (HP:0003220)2.64495289
28Cystic hygroma (HP:0000476)2.61706809
29Aplasia/Hypoplasia of the breasts (HP:0010311)2.60263284
30Oligodactyly (hands) (HP:0001180)2.60255268
31Arterial tortuosity (HP:0005116)2.58191057
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.53723383
33Premature ovarian failure (HP:0008209)2.51280493
34Secondary amenorrhea (HP:0000869)2.50900829
35Lip pit (HP:0100267)2.49302889
36Sandal gap (HP:0001852)2.48175149
37Wrist flexion contracture (HP:0001239)2.47021123
38Insulin-resistant diabetes mellitus (HP:0000831)2.46930095
39Abnormality of the phalanges of the hallux (HP:0010057)2.46116047
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.42119624
41Drooling (HP:0002307)2.38332380
42Action tremor (HP:0002345)2.36790860
43Shallow orbits (HP:0000586)2.32851015
44Nephroblastoma (Wilms tumor) (HP:0002667)2.32647519
45Meckel diverticulum (HP:0002245)2.31606875
46Pancreatic fibrosis (HP:0100732)2.30770221
47Focal seizures (HP:0007359)2.30660410
48Poor coordination (HP:0002370)2.29287953
49Midline defect of the nose (HP:0004122)2.26909137
50Vascular tortuosity (HP:0004948)2.26646445
51Abnormality of the preputium (HP:0100587)2.26472725
52Abnormal hair whorl (HP:0010721)2.25839319
53Myokymia (HP:0002411)2.21806041
54Urinary urgency (HP:0000012)2.21374133
55Embryonal renal neoplasm (HP:0011794)2.20933210
56Oligodactyly (HP:0012165)2.20637919
57Diastasis recti (HP:0001540)2.18836510
58Pulmonary fibrosis (HP:0002206)2.15435603
59Primary amenorrhea (HP:0000786)2.15245913
60Abnormality of the ileum (HP:0001549)2.14669121
61Hepatoblastoma (HP:0002884)2.13095823
62Insidious onset (HP:0003587)2.12612415
63Termporal pattern (HP:0011008)2.12612415
64Abnormality of the corticospinal tract (HP:0002492)2.12518776
65Fetal akinesia sequence (HP:0001989)2.12381239
66Hypergonadotropic hypogonadism (HP:0000815)2.12086583
67Chronic bronchitis (HP:0004469)2.11748733
68Hypoplastic iliac wings (HP:0002866)2.09325450
69Morphological abnormality of the middle ear (HP:0008609)2.07656185
70Premature rupture of membranes (HP:0001788)2.07314404
71Excessive salivation (HP:0003781)2.03184456
72Gait imbalance (HP:0002141)2.03164357
73Shoulder girdle muscle weakness (HP:0003547)2.02024828
74Duodenal stenosis (HP:0100867)2.01283647
75Small intestinal stenosis (HP:0012848)2.01283647
76Coronal craniosynostosis (HP:0004440)1.98950473
77Cutaneous finger syndactyly (HP:0010554)1.98215148
78Abnormality of the labia (HP:0000058)1.98019559
79Impaired vibration sensation in the lower limbs (HP:0002166)1.97515583
80Congenital primary aphakia (HP:0007707)1.96393237
81Spondylolisthesis (HP:0003302)1.96100724
82Ectopic kidney (HP:0000086)1.94437205
83Sloping forehead (HP:0000340)1.92801142
84Genital tract atresia (HP:0001827)1.92596737
85Prostate neoplasm (HP:0100787)1.92536302
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.92314862
87Fibular aplasia (HP:0002990)1.91286535
88Bowel diverticulosis (HP:0005222)1.88111511
89Cutaneous syndactyly (HP:0012725)1.87949580
90Broad foot (HP:0001769)1.87889839
91Abnormality of the proximal phalanges of the hand (HP:0009834)1.86073877
92Abnormality of the clitoris (HP:0000056)1.84997245
93Broad metatarsal (HP:0001783)1.84432022
94Limb dystonia (HP:0002451)1.84392949
95Absent radius (HP:0003974)1.84320686
96Molar tooth sign on MRI (HP:0002419)1.83995536
97Abnormality of midbrain morphology (HP:0002418)1.83995536
98Rhabdomyosarcoma (HP:0002859)1.83935061
99Type 2 muscle fiber atrophy (HP:0003554)1.83708777
100Choanal stenosis (HP:0000452)1.83364079
101Clubbing of toes (HP:0100760)1.82610741
102Neoplasm of the thyroid gland (HP:0100031)1.82596764
103Nephrogenic diabetes insipidus (HP:0009806)1.82035723
104Split foot (HP:0001839)1.81706285
105Aplasia involving bones of the upper limbs (HP:0009823)1.81554369
106Aplasia of the phalanges of the hand (HP:0009802)1.81554369
107Aplasia involving bones of the extremities (HP:0009825)1.81554369
108Enlarged penis (HP:0000040)1.80761857
109Abnormal gallbladder physiology (HP:0012438)1.80667256
110Cholecystitis (HP:0001082)1.80667256
111Short thumb (HP:0009778)1.78790473
112Bronchomalacia (HP:0002780)1.78684574
113Myelodysplasia (HP:0002863)1.78341930
114Abnormality of the femoral head (HP:0003368)1.78305715
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76977328
116Spastic gait (HP:0002064)1.76889486
117Abnormality of the intervertebral disk (HP:0005108)1.76657879
118Aplasia involving forearm bones (HP:0009822)1.76615607
119Absent forearm bone (HP:0003953)1.76615607
120Ankle contracture (HP:0006466)1.76342368
121Atonic seizures (HP:0010819)1.76000075
122Abnormality of the carotid arteries (HP:0005344)1.75514386
123Lower limb muscle weakness (HP:0007340)1.75429503
124Vertebral arch anomaly (HP:0008438)1.73175495
125Epileptiform EEG discharges (HP:0011182)1.72768417
126Amyotrophic lateral sclerosis (HP:0007354)1.72718709
127Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72662463
128Abnormality of femoral epiphyses (HP:0006499)1.72662463
129Overlapping toe (HP:0001845)1.72607404
130Sparse lateral eyebrow (HP:0005338)1.72309980
131Pancreatic cysts (HP:0001737)1.70421707
132Neonatal short-limb short stature (HP:0008921)1.69905795
133Turricephaly (HP:0000262)1.69621587
134Vaginal atresia (HP:0000148)1.69338357
135Astrocytoma (HP:0009592)1.68337376
136Abnormality of the astrocytes (HP:0100707)1.68337376
137Nonprogressive disorder (HP:0003680)1.67012663
138Medial flaring of the eyebrow (HP:0010747)1.66913470
139Microglossia (HP:0000171)1.65105723
140EEG with generalized epileptiform discharges (HP:0011198)1.64161213
141Bicornuate uterus (HP:0000813)1.63346974
142Aqueductal stenosis (HP:0002410)1.62902810
143Insomnia (HP:0100785)1.60560775
144Epileptic encephalopathy (HP:0200134)1.60351165
145Protrusio acetabuli (HP:0003179)1.59658409
146Atrioventricular canal defect (HP:0006695)1.57946309
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.57466682
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57466682
149Hammertoe (HP:0001765)1.57005659
150Hypsarrhythmia (HP:0002521)1.56090871
151Generalized tonic-clonic seizures (HP:0002069)1.54956286
152Increased nuchal translucency (HP:0010880)1.54754885
153Bladder diverticulum (HP:0000015)1.53548556
154Abnormality of dentin (HP:0010299)1.53541233
155Urinary bladder sphincter dysfunction (HP:0002839)1.53308814
156Atrophic scars (HP:0001075)1.52952018
157Limb-girdle muscle weakness (HP:0003325)1.52697102
158Ankle clonus (HP:0011448)1.52342531
159Febrile seizures (HP:0002373)1.51922464
160Omphalocele (HP:0001539)1.50751599
161Abnormality of the hip-girdle musculature (HP:0001445)1.50656316
162Abnormality of the musculature of the pelvis (HP:0001469)1.50656316
163Absent eyebrow (HP:0002223)1.49247074
164Megalencephaly (HP:0001355)1.47675956
165Overriding aorta (HP:0002623)1.46107155
166Arnold-Chiari malformation (HP:0002308)1.46060267
167Overgrowth (HP:0001548)1.43736505
168Glioma (HP:0009733)1.42846943
169Hypoventilation (HP:0002791)1.42329370
170Heterochromia iridis (HP:0001100)1.41160683
171Absent eyelashes (HP:0000561)1.39569912
172Pheochromocytoma (HP:0002666)1.38865501
173Ependymoma (HP:0002888)1.37844294
174Pulmonic stenosis (HP:0001642)1.37529717
175Medulloblastoma (HP:0002885)1.37219549
176Soft skin (HP:0000977)1.36064143
177Sleep apnea (HP:0010535)1.35769359
178Buphthalmos (HP:0000557)1.35683770
179Failure to thrive in infancy (HP:0001531)1.35524031
180Bifid tongue (HP:0010297)1.35522202
181Spastic diplegia (HP:0001264)1.34996862
182Neurofibrillary tangles (HP:0002185)1.34154154
183Preaxial foot polydactyly (HP:0001841)1.34056477
184Complete atrioventricular canal defect (HP:0001674)1.33531981
185Myelomeningocele (HP:0002475)1.33334722
186High anterior hairline (HP:0009890)1.33043048
187Wide anterior fontanel (HP:0000260)1.32060167
188Heterotopia (HP:0002282)1.31410388
189Labial hypoplasia (HP:0000066)1.30820593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.44673475
2MAP3K64.19815425
3MARK13.92307096
4LATS23.90203630
5STK38L3.55471015
6PLK43.39256961
7ERBB43.16895564
8MUSK3.09291348
9BRAF2.89510893
10PNCK2.75000790
11TAOK32.70163855
12MAP3K92.63787074
13CDC72.56361502
14TTK2.54596441
15KSR22.47320332
16BMPR22.34078015
17MOS2.30203299
18BCR2.23947797
19MAP3K42.09659550
20NTRK12.05853117
21RAF12.00203429
22MAP2K71.94110633
23PDGFRA1.85944702
24WNK31.84028400
25TAOK11.80010222
26ARAF1.78569155
27TSSK61.70630990
28MAP3K131.64929786
29NTRK31.64580032
30CDK81.64005141
31STK31.63883841
32TNIK1.61439554
33KSR11.59211744
34EEF2K1.50844560
35MAPK131.47291588
36MINK11.46999717
37CHEK21.45936665
38MELK1.36793256
39PRKD31.36126444
40TRIM281.34129385
41SGK21.33554859
42FGFR21.33331312
43UHMK11.32522240
44PLK11.26154056
45PAK61.21292412
46CDK91.19513593
47PLK21.18694711
48LIMK11.14294676
49MKNK21.13573827
50AKT31.08274058
51DYRK21.07739623
52ERBB31.07175552
53MET1.06250289
54MKNK11.05276735
55PLK31.01358661
56MAPKAPK30.99308867
57MAP2K40.99190589
58NEK20.98260920
59PTK20.95727207
60CDK190.93856302
61NUAK10.92570893
62STK380.92525800
63DMPK0.90979418
64STK100.90313371
65ACVR1B0.89981122
66CASK0.88924024
67SGK4940.87097890
68SGK2230.87097890
69STK240.87041644
70CAMK2B0.86042345
71PAK20.85550207
72PRKCG0.84639834
73CDK50.84359029
74SCYL20.83681164
75TAF10.82946581
76NEK90.81904366
77CDK180.81054264
78NTRK20.80770756
79CDK140.78967172
80CAMK1G0.77686876
81EPHB20.77239822
82BMPR1B0.77095388
83RPS6KA40.77054364
84TYRO30.76122671
85DAPK20.75947364
86CDK150.75240241
87PRKCE0.74718685
88SGK30.73042656
89PBK0.71128128
90TESK10.69465442
91CDK11A0.68564463
92DYRK1A0.68199481
93MAP3K80.67369239
94MAP3K120.66821427
95ROCK20.63956347
96FGFR10.63504924
97AURKB0.63315182
98STK390.61398286
99BRD40.61107417
100CDK30.60315806
101CSNK1G10.59013309
102AURKA0.56902742
103ABL20.56700948
104CHEK10.56040429
105RET0.55920010
106DAPK10.55904561
107CSNK1E0.55647366
108PAK30.54941855
109PRKAA10.54794725
110ATM0.54379694
111EPHA40.52564718
112WEE10.52036751
113DDR20.51979669
114NEK10.51467442
115OXSR10.51091796
116RIPK10.50602441
117PDGFRB0.49508227
118CSNK1G20.48480638
119MAP3K50.47130404
120PRKD20.46054072
121SRPK10.45911279
122VRK10.45814156
123YES10.45749505
124PRKAA20.45390245
125NLK0.44271477
126FLT30.43851367
127BUB10.43664315
128CAMK2D0.42983537
129ALK0.42298239
130CDK120.41757467
131DYRK30.41034412
132CSNK1D0.40899207
133PKN20.39425734
134MAPKAPK50.36440582
135CAMK2A0.36163738
136FRK0.36056510
137BRSK10.35815696
138CDK10.35560984
139MARK20.34409463
140CSNK1G30.31897674
141NEK60.31697652
142TRPM70.29178071
143CDK20.28767435
144CCNB10.28585021
145BRSK20.25001756
146MAP2K10.24022767
147ABL10.21969098
148MAPK100.21497883
149SIK30.20420240
150PINK10.20019657
151AKT10.19514645
152CDK70.18215089
153CHUK0.18079642
154EPHA30.17324807
155CSNK1A1L0.16947080
156GSK3B0.16923174
157ATR0.16754427

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.11708772
2Basal transcription factors_Homo sapiens_hsa030223.73055795
3RNA degradation_Homo sapiens_hsa030183.57698738
4Ovarian steroidogenesis_Homo sapiens_hsa049133.27914357
5Circadian rhythm_Homo sapiens_hsa047102.79981370
6Oocyte meiosis_Homo sapiens_hsa041142.69066606
7Fanconi anemia pathway_Homo sapiens_hsa034602.33983153
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.32278885
9Pancreatic cancer_Homo sapiens_hsa052122.26914900
10Homologous recombination_Homo sapiens_hsa034402.11299571
11TGF-beta signaling pathway_Homo sapiens_hsa043502.05636787
12GABAergic synapse_Homo sapiens_hsa047271.95320922
13p53 signaling pathway_Homo sapiens_hsa041151.94583545
14Vitamin B6 metabolism_Homo sapiens_hsa007501.80531121
15RNA transport_Homo sapiens_hsa030131.74631355
16Colorectal cancer_Homo sapiens_hsa052101.72753182
17Non-homologous end-joining_Homo sapiens_hsa034501.72210359
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69545751
19GnRH signaling pathway_Homo sapiens_hsa049121.63925367
20Base excision repair_Homo sapiens_hsa034101.62586156
21Thyroid cancer_Homo sapiens_hsa052161.60978887
22Axon guidance_Homo sapiens_hsa043601.59846729
23Ether lipid metabolism_Homo sapiens_hsa005651.55694996
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54310039
25Linoleic acid metabolism_Homo sapiens_hsa005911.52853490
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50199594
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48142097
28Dorso-ventral axis formation_Homo sapiens_hsa043201.48034820
29Morphine addiction_Homo sapiens_hsa050321.45736098
30Prolactin signaling pathway_Homo sapiens_hsa049171.41909488
31MicroRNAs in cancer_Homo sapiens_hsa052061.40555964
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39205018
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37740708
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36053312
35Endometrial cancer_Homo sapiens_hsa052131.34118790
36Insulin secretion_Homo sapiens_hsa049111.31403022
37Basal cell carcinoma_Homo sapiens_hsa052171.31252034
38RNA polymerase_Homo sapiens_hsa030201.29206680
39Choline metabolism in cancer_Homo sapiens_hsa052311.27556227
40Long-term depression_Homo sapiens_hsa047301.22723870
41mRNA surveillance pathway_Homo sapiens_hsa030151.21821494
42Hippo signaling pathway_Homo sapiens_hsa043901.18908211
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14730098
44Taste transduction_Homo sapiens_hsa047421.12106112
45Nucleotide excision repair_Homo sapiens_hsa034201.10216426
46ECM-receptor interaction_Homo sapiens_hsa045121.09561752
47FoxO signaling pathway_Homo sapiens_hsa040681.08085575
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03866723
49Nicotine addiction_Homo sapiens_hsa050331.03574974
50Serotonergic synapse_Homo sapiens_hsa047261.00848938
51Mismatch repair_Homo sapiens_hsa034300.99634124
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99161544
53Renin secretion_Homo sapiens_hsa049240.98471311
54Renal cell carcinoma_Homo sapiens_hsa052110.97749495
55Gastric acid secretion_Homo sapiens_hsa049710.97695492
56Adherens junction_Homo sapiens_hsa045200.96977892
57Vibrio cholerae infection_Homo sapiens_hsa051100.96415128
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94224590
59Ras signaling pathway_Homo sapiens_hsa040140.92674716
60Dilated cardiomyopathy_Homo sapiens_hsa054140.92200651
61Glutamatergic synapse_Homo sapiens_hsa047240.91897348
62ErbB signaling pathway_Homo sapiens_hsa040120.90052910
63Selenocompound metabolism_Homo sapiens_hsa004500.89306199
64Olfactory transduction_Homo sapiens_hsa047400.88548628
65Focal adhesion_Homo sapiens_hsa045100.88063565
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87946296
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87647486
68Protein digestion and absorption_Homo sapiens_hsa049740.85709178
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84705981
70DNA replication_Homo sapiens_hsa030300.84551884
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84322642
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.83200696
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82495101
74Thyroid hormone synthesis_Homo sapiens_hsa049180.81130082
75Salivary secretion_Homo sapiens_hsa049700.79381897
76Proteoglycans in cancer_Homo sapiens_hsa052050.78297451
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76330396
78Long-term potentiation_Homo sapiens_hsa047200.75901705
79Steroid biosynthesis_Homo sapiens_hsa001000.75595436
80Rap1 signaling pathway_Homo sapiens_hsa040150.74598069
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.73996218
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72823771
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72786162
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72676348
85Non-small cell lung cancer_Homo sapiens_hsa052230.72546743
86Synaptic vesicle cycle_Homo sapiens_hsa047210.71017480
87MAPK signaling pathway_Homo sapiens_hsa040100.70861969
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70059682
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70024037
90Wnt signaling pathway_Homo sapiens_hsa043100.68860956
91VEGF signaling pathway_Homo sapiens_hsa043700.67631174
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67409443
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65310319
94cAMP signaling pathway_Homo sapiens_hsa040240.65013695
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64999904
96Calcium signaling pathway_Homo sapiens_hsa040200.64781346
97Estrogen signaling pathway_Homo sapiens_hsa049150.64368394
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64157402
99AMPK signaling pathway_Homo sapiens_hsa041520.61527609
100mTOR signaling pathway_Homo sapiens_hsa041500.60978473
101HTLV-I infection_Homo sapiens_hsa051660.60422941
102Glioma_Homo sapiens_hsa052140.58807363
103Dopaminergic synapse_Homo sapiens_hsa047280.57601010
104Prostate cancer_Homo sapiens_hsa052150.56902028
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.56214073
106Melanoma_Homo sapiens_hsa052180.55963325
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.55923704
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54916856
109Oxytocin signaling pathway_Homo sapiens_hsa049210.54595339
110Hepatitis B_Homo sapiens_hsa051610.54196300
111Type II diabetes mellitus_Homo sapiens_hsa049300.53011350
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52235109
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52234781
114Alcoholism_Homo sapiens_hsa050340.51844286
115Purine metabolism_Homo sapiens_hsa002300.51018957
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49923079
117Glucagon signaling pathway_Homo sapiens_hsa049220.47741855
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47479359
119Phototransduction_Homo sapiens_hsa047440.46715355
120Pathways in cancer_Homo sapiens_hsa052000.46511495
121Chronic myeloid leukemia_Homo sapiens_hsa052200.45993285
122Cholinergic synapse_Homo sapiens_hsa047250.45891952
123Cocaine addiction_Homo sapiens_hsa050300.44715079
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.43794308
125Hedgehog signaling pathway_Homo sapiens_hsa043400.43783608
126Amphetamine addiction_Homo sapiens_hsa050310.41763475
127Notch signaling pathway_Homo sapiens_hsa043300.41396820
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40287485
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40249669
130Melanogenesis_Homo sapiens_hsa049160.38437870
131Arachidonic acid metabolism_Homo sapiens_hsa005900.38085452
132Gap junction_Homo sapiens_hsa045400.37142379
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36754778
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36048484
135Small cell lung cancer_Homo sapiens_hsa052220.35343175
136Bladder cancer_Homo sapiens_hsa052190.34546018
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33541770
138Shigellosis_Homo sapiens_hsa051310.32606071
139Inositol phosphate metabolism_Homo sapiens_hsa005620.31779685
140Herpes simplex infection_Homo sapiens_hsa051680.31502722
141Circadian entrainment_Homo sapiens_hsa047130.30497193
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28689528
143Tight junction_Homo sapiens_hsa045300.28524976

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