ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.89229441
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.87186969
3	protein complex biogenesis (GO:0070271)	4.77360445
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.72839566
5	ATP synthesis coupled proton transport (GO:0015986)	4.72839566
6	mitochondrial respiratory chain complex assembly (GO:0033108)	4.59761761
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58078593
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.44337971
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.44337971
10	NADH dehydrogenase complex assembly (GO:0010257)	4.44337971
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.35255834
12	respiratory electron transport chain (GO:0022904)	4.11391605
13	proteasome assembly (GO:0043248)	4.10537846
14	chaperone-mediated protein transport (GO:0072321)	4.09390074
15	electron transport chain (GO:0022900)	4.07033476
16	cullin deneddylation (GO:0010388)	3.76161972
17	respiratory chain complex IV assembly (GO:0008535)	3.65498727
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.60673130
19	protein deneddylation (GO:0000338)	3.60521366
20	cytochrome complex assembly (GO:0017004)	3.60090522
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.42605521
22	DNA double-strand break processing (GO:0000729)	3.40519351
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36115020
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36115020
25	pseudouridine synthesis (GO:0001522)	3.34305606
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.30716316
27	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.25595104
28	protein-cofactor linkage (GO:0018065)	3.24480160
29	metallo-sulfur cluster assembly (GO:0031163)	3.21778980
30	iron-sulfur cluster assembly (GO:0016226)	3.21778980
31	protein targeting to mitochondrion (GO:0006626)	3.19645336
32	termination of RNA polymerase III transcription (GO:0006386)	3.18375064
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18375064
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.16575398
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.14800318
36	establishment of protein localization to mitochondrion (GO:0072655)	3.12495281
37	pyrimidine nucleotide catabolic process (GO:0006244)	3.09781376
38	ubiquinone biosynthetic process (GO:0006744)	3.06636503
39	hydrogen ion transmembrane transport (GO:1902600)	3.04955939
40	establishment of integrated proviral latency (GO:0075713)	3.04057908
41	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.02450280
42	regulation of mitotic spindle checkpoint (GO:1903504)	3.02450280
43	regulation of mitochondrial translation (GO:0070129)	3.01290596
44	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.01042174
45	protein localization to mitochondrion (GO:0070585)	2.99608074
46	sequestering of actin monomers (GO:0042989)	2.99097950
47	regulation of cellular amino acid metabolic process (GO:0006521)	2.98480703
48	ATP biosynthetic process (GO:0006754)	2.97066467
49	inositol phosphate catabolic process (GO:0071545)	2.95486085
50	mannosylation (GO:0097502)	2.92229654
51	centriole replication (GO:0007099)	2.92046010
52	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.91006163
53	oxidative phosphorylation (GO:0006119)	2.90491596
54	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.90236146
55	purine nucleobase biosynthetic process (GO:0009113)	2.89692958
56	replication fork processing (GO:0031297)	2.87993189
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.87615189
58	peptidyl-histidine modification (GO:0018202)	2.87600853
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.87277599
60	regulation of cilium movement (GO:0003352)	2.86431289
61	base-excision repair, AP site formation (GO:0006285)	2.86262953
62	inner mitochondrial membrane organization (GO:0007007)	2.82171801
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82066515
64	proton transport (GO:0015992)	2.77641071
65	ubiquinone metabolic process (GO:0006743)	2.77639743
66	xenobiotic catabolic process (GO:0042178)	2.77486348
67	cellular ketone body metabolic process (GO:0046950)	2.77351307
68	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.76284968
69	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.74763194
70	inositol phosphate dephosphorylation (GO:0046855)	2.74763194
71	GMP metabolic process (GO:0046037)	2.74546487
72	rRNA modification (GO:0000154)	2.73630161
73	GPI anchor biosynthetic process (GO:0006506)	2.72736883
74	branched-chain amino acid catabolic process (GO:0009083)	2.72303475
75	hydrogen transport (GO:0006818)	2.72097298
76	negative regulation of membrane potential (GO:0045837)	2.71775906
77	platelet dense granule organization (GO:0060155)	2.71499637
78	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.71369179
79	tRNA processing (GO:0008033)	2.70031206
80	deoxyribonucleotide catabolic process (GO:0009264)	2.69781582
81	positive regulation of growth hormone secretion (GO:0060124)	2.69634628
82	spliceosomal snRNP assembly (GO:0000387)	2.69304120
83	guanosine-containing compound biosynthetic process (GO:1901070)	2.69249314
84	behavioral response to nicotine (GO:0035095)	2.68456409
85	amino acid salvage (GO:0043102)	2.67650025
86	L-methionine salvage (GO:0071267)	2.67650025
87	L-methionine biosynthetic process (GO:0071265)	2.67650025
88	positive regulation of mitochondrial fission (GO:0090141)	2.65685308
89	chromatin remodeling at centromere (GO:0031055)	2.65481437
90	regulation of helicase activity (GO:0051095)	2.63142879
91	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.63043044
92	negative regulation of ligase activity (GO:0051352)	2.63043044
93	C-terminal protein lipidation (GO:0006501)	2.62576629
94	aldehyde catabolic process (GO:0046185)	2.62216355
95	mitochondrial transport (GO:0006839)	2.61547461
96	negative regulation of cation channel activity (GO:2001258)	2.60457254
97	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.58536846
98	deoxyribose phosphate catabolic process (GO:0046386)	2.57051342
99	negative regulation of heart rate (GO:0010459)	2.56630835
100	GTP biosynthetic process (GO:0006183)	2.56279518

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.78352397
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.22420531
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.21486442
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76571397
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.51679556
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.44216810
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.34354010
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.09941543
9	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.98354235
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.91550556
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.82269263
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.59940342
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.56655511
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.55353267
15	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.47038169
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.39053930
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28643968
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.26167315
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25796644
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.24461036
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14945271
22	VDR_22108803_ChIP-Seq_LS180_Human	2.12343029
23	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12068417
24	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.08177790
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01823296
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.95703219
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.94467387
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.94280479
29	EWS_26573619_Chip-Seq_HEK293_Human	1.87468747
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.87266422
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.78512254
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.75253721
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.73826577
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.73127033
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.62852146
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.62720833
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.61512787
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.60738914
39	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.57272960
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.56287621
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.56053297
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.55535575
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54752469
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.53445729
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.51765582
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49020491
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.48340818
48	FUS_26573619_Chip-Seq_HEK293_Human	1.47101377
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.41078150
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.32184957
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31310902
52	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.25593135
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23688419
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23611924
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23397774
56	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21372623
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20945945
58	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20138427
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19952561
60	E2F7_22180533_ChIP-Seq_HELA_Human	1.18140760
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16965397
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14615478
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14353460
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12982685
65	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.12923027
66	P300_19829295_ChIP-Seq_ESCs_Human	1.12516566
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.11542382
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.10957477
69	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10771770
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10434217
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.09885934
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.02776284
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98199134
74	GBX2_23144817_ChIP-Seq_PC3_Human	0.98115800
75	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.98080001
76	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.97206533
77	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96787559
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96262397
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95483106
80	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94948972
81	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94804854
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94587105
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94346333
84	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93105042
85	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.92780344
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.92405889
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.92140958
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91477377
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91062548
90	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90029685
91	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.89081727
92	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88541956
93	AR_20517297_ChIP-Seq_VCAP_Human	0.87896624
94	EZH2_22144423_ChIP-Seq_EOC_Human	0.87460612
95	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87335641
96	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85856976
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.84945576
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.82234294
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.81536905
100	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.79681521

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.51068924
2	MP0008058_abnormal_DNA_repair	3.34167313
3	MP0002736_abnormal_nociception_after	3.20145277
4	MP0001968_abnormal_touch/_nociception	2.81181341
5	MP0003122_maternal_imprinting	2.76651162
6	MP0004147_increased_porphyrin_level	2.64661850
7	MP0006072_abnormal_retinal_apoptosis	2.56512584
8	MP0003787_abnormal_imprinting	2.54042697
9	MP0003011_delayed_dark_adaptation	2.45834177
10	MP0002102_abnormal_ear_morphology	2.33335251
11	MP0003121_genomic_imprinting	2.14243153
12	MP0002837_dystrophic_cardiac_calcinosis	2.11876227
13	MP0009697_abnormal_copulation	2.11348267
14	MP0001984_abnormal_olfaction	2.10505539
15	MP0006036_abnormal_mitochondrial_physio	2.10044819
16	MP0010094_abnormal_chromosome_stability	2.08511358
17	MP0006276_abnormal_autonomic_nervous	2.07035624
18	MP0008877_abnormal_DNA_methylation	1.91743919
19	MP0001905_abnormal_dopamine_level	1.91536755
20	MP0005253_abnormal_eye_physiology	1.88618425
21	MP0009046_muscle_twitch	1.88269302
22	MP0003880_abnormal_central_pattern	1.87287984
23	MP0003186_abnormal_redox_activity	1.84732188
24	MP0003786_premature_aging	1.73216744
25	MP0006035_abnormal_mitochondrial_morpho	1.68545037
26	MP0008872_abnormal_physiological_respon	1.68511653
27	MP0002272_abnormal_nervous_system	1.61330819
28	MP0001188_hyperpigmentation	1.59617809
29	MP0002938_white_spotting	1.57264584
30	MP0005551_abnormal_eye_electrophysiolog	1.56379403
31	MP0003123_paternal_imprinting	1.55897259
32	MP0003693_abnormal_embryo_hatching	1.55618234
33	MP0004957_abnormal_blastocyst_morpholog	1.55047488
34	MP0005084_abnormal_gallbladder_morpholo	1.55040450
35	MP0004133_heterotaxia	1.53353903
36	MP0008789_abnormal_olfactory_epithelium	1.47190566
37	MP0000372_irregular_coat_pigmentation	1.46317087
38	MP0009745_abnormal_behavioral_response	1.43087256
39	MP0008995_early_reproductive_senescence	1.37978638
40	MP0004142_abnormal_muscle_tone	1.33442238
41	MP0006292_abnormal_olfactory_placode	1.28584788
42	MP0003718_maternal_effect	1.28440967
43	MP0003137_abnormal_impulse_conducting	1.24384635
44	MP0005394_taste/olfaction_phenotype	1.24230299
45	MP0005499_abnormal_olfactory_system	1.24230299
46	MP0000647_abnormal_sebaceous_gland	1.23754593
47	MP0008932_abnormal_embryonic_tissue	1.22294109
48	MP0003567_abnormal_fetal_cardiomyocyte	1.21627485
49	MP0001661_extended_life_span	1.21100899
50	MP0005464_abnormal_platelet_physiology	1.18262029
51	MP0005220_abnormal_exocrine_pancreas	1.18006618
52	MP0003806_abnormal_nucleotide_metabolis	1.17906752
53	MP0004145_abnormal_muscle_electrophysio	1.16716616
54	MP0010386_abnormal_urinary_bladder	1.12682875
55	MP0008875_abnormal_xenobiotic_pharmacok	1.11595168
56	MP0002751_abnormal_autonomic_nervous	1.11298333
57	MP0001970_abnormal_pain_threshold	1.11224348
58	MP0003111_abnormal_nucleus_morphology	1.09010029
59	MP0002734_abnormal_mechanical_nocicepti	1.08899892
60	MP0002638_abnormal_pupillary_reflex	1.08321812
61	MP0002572_abnormal_emotion/affect_behav	1.08136749
62	MP0002067_abnormal_sensory_capabilities	1.04580805
63	MP0002876_abnormal_thyroid_physiology	1.04389979
64	MP0000358_abnormal_cell_content/	1.04384056
65	MP0002735_abnormal_chemical_nociception	1.04226828
66	MP0004270_analgesia	1.01982956
67	MP0004859_abnormal_synaptic_plasticity	1.00444158
68	MP0002160_abnormal_reproductive_system	1.00429002
69	MP0005645_abnormal_hypothalamus_physiol	0.98880140
70	MP0001293_anophthalmia	0.97397780
71	MP0004085_abnormal_heartbeat	0.97124258
72	MP0002557_abnormal_social/conspecific_i	0.96911143
73	MP0001919_abnormal_reproductive_system	0.95776154
74	MP0004924_abnormal_behavior	0.95622732
75	MP0005386_behavior/neurological_phenoty	0.95622732
76	MP0003635_abnormal_synaptic_transmissio	0.94361889
77	MP0002064_seizures	0.92552407
78	MP0005410_abnormal_fertilization	0.92454306
79	MP0001727_abnormal_embryo_implantation	0.91962167
80	MP0000631_abnormal_neuroendocrine_gland	0.91067982
81	MP0002733_abnormal_thermal_nociception	0.90719026
82	MP0004215_abnormal_myocardial_fiber	0.90166260
83	MP0005646_abnormal_pituitary_gland	0.90062915
84	MP0005389_reproductive_system_phenotype	0.88819705
85	MP0000427_abnormal_hair_cycle	0.87506282
86	MP0008007_abnormal_cellular_replicative	0.86773613
87	MP0002210_abnormal_sex_determination	0.86090881
88	MP0005332_abnormal_amino_acid	0.83833089
89	MP0008775_abnormal_heart_ventricle	0.83449989
90	MP0001929_abnormal_gametogenesis	0.82407575
91	MP0002063_abnormal_learning/memory/cond	0.80725854
92	MP0005423_abnormal_somatic_nervous	0.80554554
93	MP0005391_vision/eye_phenotype	0.78934742
94	MP0002184_abnormal_innervation	0.78718274
95	MP0002752_abnormal_somatic_nervous	0.77554752
96	MP0005535_abnormal_body_temperature	0.77456581
97	MP0000653_abnormal_sex_gland	0.75169311
98	MP0001764_abnormal_homeostasis	0.74973755
99	MP0002693_abnormal_pancreas_physiology	0.72341888
100	MP0003077_abnormal_cell_cycle	0.72313775

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.90138957
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.57837517
3	Acute encephalopathy (HP:0006846)	4.49927120
4	Mitochondrial inheritance (HP:0001427)	4.40318477
5	Progressive macrocephaly (HP:0004481)	4.21123904
6	Increased CSF lactate (HP:0002490)	4.06785501
7	Hepatocellular necrosis (HP:0001404)	3.89676795
8	3-Methylglutaconic aciduria (HP:0003535)	3.84062299
9	Hepatic necrosis (HP:0002605)	3.72077446
10	Renal Fanconi syndrome (HP:0001994)	3.47384929
11	Increased hepatocellular lipid droplets (HP:0006565)	3.41560378
12	Methylmalonic acidemia (HP:0002912)	3.38795236
13	Cerebral edema (HP:0002181)	3.34990037
14	Lipid accumulation in hepatocytes (HP:0006561)	3.20399033
15	Methylmalonic aciduria (HP:0012120)	3.05973603
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.94314289
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.94314289
18	Lactic acidosis (HP:0003128)	2.92839172
19	Increased intramyocellular lipid droplets (HP:0012240)	2.88999788
20	Increased serum lactate (HP:0002151)	2.88027960
21	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.80164493
22	Respiratory failure (HP:0002878)	2.68548671
23	Hyperglycinemia (HP:0002154)	2.64599607
24	Molar tooth sign on MRI (HP:0002419)	2.62163165
25	Abnormality of midbrain morphology (HP:0002418)	2.62163165
26	Pancreatic islet-cell hyperplasia (HP:0004510)	2.58510418
27	Optic disc pallor (HP:0000543)	2.46056453
28	Hypothermia (HP:0002045)	2.39413568
29	Type I transferrin isoform profile (HP:0003642)	2.37613291
30	Increased muscle lipid content (HP:0009058)	2.37474248
31	Pancreatic cysts (HP:0001737)	2.37271456
32	Nephrogenic diabetes insipidus (HP:0009806)	2.37047628
33	Medial flaring of the eyebrow (HP:0010747)	2.36306235
34	Abnormality of alanine metabolism (HP:0010916)	2.35353302
35	Hyperalaninemia (HP:0003348)	2.35353302
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35353302
37	Exercise intolerance (HP:0003546)	2.34956026
38	Abnormal protein glycosylation (HP:0012346)	2.32037513
39	Abnormal glycosylation (HP:0012345)	2.32037513
40	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.32037513
41	Abnormal protein N-linked glycosylation (HP:0012347)	2.32037513
42	Lethargy (HP:0001254)	2.30736739
43	Congenital, generalized hypertrichosis (HP:0004540)	2.29802286
44	Exertional dyspnea (HP:0002875)	2.29587899
45	Gait imbalance (HP:0002141)	2.27477362
46	Pancreatic fibrosis (HP:0100732)	2.27315513
47	Aplastic anemia (HP:0001915)	2.25809259
48	Abnormality of the pancreatic islet cells (HP:0006476)	2.24638471
49	Abnormality of endocrine pancreas physiology (HP:0012093)	2.24638471
50	True hermaphroditism (HP:0010459)	2.22030651
51	Abnormality of methionine metabolism (HP:0010901)	2.19915312
52	Congenital primary aphakia (HP:0007707)	2.19773627
53	Respiratory difficulties (HP:0002880)	2.14397878
54	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.12954126
55	Dicarboxylic aciduria (HP:0003215)	2.12954126
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12565099
57	Abnormality of the anterior horn cell (HP:0006802)	2.12067121
58	Degeneration of anterior horn cells (HP:0002398)	2.12067121
59	Emotional lability (HP:0000712)	2.11673815
60	Ketoacidosis (HP:0001993)	2.11057940
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09666156
62	Abnormality of glycine metabolism (HP:0010895)	2.06989815
63	Abnormality of serine family amino acid metabolism (HP:0010894)	2.06989815
64	X-linked dominant inheritance (HP:0001423)	2.05048740
65	Abnormality of renal resorption (HP:0011038)	2.05036574
66	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.04396896
67	Cerebral hypomyelination (HP:0006808)	1.99841794
68	Severe combined immunodeficiency (HP:0004430)	1.98153467
69	Prominent metopic ridge (HP:0005487)	1.97794232
70	Nephronophthisis (HP:0000090)	1.96039277
71	Type II lissencephaly (HP:0007260)	1.95371760
72	Hyperinsulinemic hypoglycemia (HP:0000825)	1.94654574
73	Petechiae (HP:0000967)	1.94626436
74	CNS demyelination (HP:0007305)	1.94271855
75	Limb dystonia (HP:0002451)	1.92452551
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91539297
77	Muscular hypotonia of the trunk (HP:0008936)	1.90884535
78	Abnormality of serum amino acid levels (HP:0003112)	1.90617511
79	Hypoproteinemia (HP:0003075)	1.89156814
80	Leukodystrophy (HP:0002415)	1.87740576
81	Hyperglycinuria (HP:0003108)	1.87485215
82	Disproportionate short-trunk short stature (HP:0003521)	1.84169360
83	Abolished electroretinogram (ERG) (HP:0000550)	1.83648936
84	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.83506955
85	CNS hypomyelination (HP:0003429)	1.82816838
86	Reduced antithrombin III activity (HP:0001976)	1.82522368
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.82238134
88	Polyphagia (HP:0002591)	1.80806665
89	Abnormality of the metopic suture (HP:0005556)	1.80178787
90	Myokymia (HP:0002411)	1.79451779
91	Retinal dysplasia (HP:0007973)	1.77578288
92	Postnatal microcephaly (HP:0005484)	1.77274840
93	Abnormality of the labia minora (HP:0012880)	1.76868131
94	Abnormality of vitamin B metabolism (HP:0004340)	1.76735121
95	Thyroid-stimulating hormone excess (HP:0002925)	1.75075166
96	Abnormality of chromosome stability (HP:0003220)	1.74758104
97	Hypoglycemic coma (HP:0001325)	1.73564187
98	Glycosuria (HP:0003076)	1.72699528
99	Abnormality of urine glucose concentration (HP:0011016)	1.72699528
100	Severe muscular hypotonia (HP:0006829)	1.72144491

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.93004711
2	VRK2	2.68881520
3	NUAK1	2.67055207
4	WNK3	2.61515820
5	BCKDK	2.55350065
6	STK16	2.52968526
7	SRPK1	2.32711529
8	FRK	2.03153725
9	PLK4	2.02763446
10	MAP2K7	1.91518818
11	MAP3K4	1.91314429
12	BMPR1B	1.85819120
13	CDC7	1.83290631
14	EIF2AK3	1.82333781
15	MAPK13	1.70611930
16	TRIM28	1.61543637
17	VRK1	1.58417470
18	TNIK	1.56804048
19	MKNK2	1.55159594
20	RPS6KA4	1.52763850
21	CASK	1.52527591
22	DYRK2	1.52301796
23	PLK3	1.50428351
24	DYRK3	1.50226893
25	KDR	1.49974692
26	MKNK1	1.45119480
27	BUB1	1.42474984
28	MST4	1.35417450
29	PDK2	1.35248571
30	EIF2AK1	1.32746640
31	PIM2	1.32205168
32	CCNB1	1.30369232
33	PLK2	1.29402878
34	GRK1	1.19639411
35	LIMK1	1.17916743
36	AKT3	1.17492776
37	CSNK1G3	1.15280899
38	MAP3K12	1.15157970
39	CAMKK2	1.14604176
40	CSNK1G2	1.14027369
41	MARK1	1.10761573
42	CSNK1G1	1.05478861
43	ADRBK2	1.05066283
44	NEK1	1.03327115
45	TESK2	1.02587848
46	ZAK	1.00189125
47	BCR	0.99635043
48	TESK1	0.97093025
49	EPHA4	0.96331319
50	ERBB3	0.94860014
51	PLK1	0.90777074
52	FLT3	0.90516991
53	NME1	0.87847500
54	DAPK1	0.86363227
55	BRAF	0.83658756
56	TAF1	0.83202637
57	ATR	0.80992676
58	PHKG1	0.78361023
59	PHKG2	0.78361023
60	TXK	0.77775924
61	ILK	0.74583069
62	TTK	0.73632645
63	PRKCG	0.73309347
64	GRK5	0.72713603
65	MATK	0.71805467
66	INSRR	0.71221750
67	MYLK	0.70618975
68	MINK1	0.68595960
69	PAK3	0.68424303
70	PRKCE	0.66380269
71	TEC	0.66306766
72	CSNK1A1L	0.66177067
73	NME2	0.65002728
74	NTRK1	0.61897459
75	PINK1	0.61357475
76	RPS6KA5	0.57865576
77	ADRBK1	0.54577210
78	BRSK2	0.53382571
79	RAF1	0.50621287
80	AURKA	0.50054257
81	CSNK2A2	0.49015376
82	AURKB	0.46697414
83	ATM	0.46180158
84	BMX	0.45482812
85	PAK1	0.45353534
86	CAMK2A	0.44267270
87	CDK14	0.43375242
88	WEE1	0.42935673
89	CSNK2A1	0.41807385
90	CAMK2D	0.40486332
91	PRKACA	0.39678164
92	MAP3K6	0.39200943
93	TSSK6	0.38630923
94	BRSK1	0.34659868
95	CSNK1A1	0.34463811
96	DYRK1A	0.33961239
97	DAPK3	0.33072552
98	MAP3K5	0.32354774
99	CDK8	0.30842360
100	PRKCA	0.29443462

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.96186092
2	Parkinsons disease_Homo sapiens_hsa05012	3.46690866
3	Proteasome_Homo sapiens_hsa03050	3.42335326
4	Protein export_Homo sapiens_hsa03060	3.07248088
5	Mismatch repair_Homo sapiens_hsa03430	2.74096827
6	RNA polymerase_Homo sapiens_hsa03020	2.59239785
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33290425
8	Huntingtons disease_Homo sapiens_hsa05016	2.30244080
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16442554
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14661795
11	Alzheimers disease_Homo sapiens_hsa05010	2.14596340
12	Fatty acid elongation_Homo sapiens_hsa00062	2.04802962
13	Homologous recombination_Homo sapiens_hsa03440	1.98186051
14	Ribosome_Homo sapiens_hsa03010	1.97750285
15	DNA replication_Homo sapiens_hsa03030	1.81498649
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81149341
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.74745123
18	Propanoate metabolism_Homo sapiens_hsa00640	1.70933426
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68880995
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67058006
21	Base excision repair_Homo sapiens_hsa03410	1.66851774
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.65891068
23	Sulfur metabolism_Homo sapiens_hsa00920	1.62217755
24	Butanoate metabolism_Homo sapiens_hsa00650	1.61103827
25	Basal transcription factors_Homo sapiens_hsa03022	1.54553003
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53829943
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53826417
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53105574
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51394415
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44165547
31	RNA degradation_Homo sapiens_hsa03018	1.43331349
32	Regulation of autophagy_Homo sapiens_hsa04140	1.42786943
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.38671885
34	Spliceosome_Homo sapiens_hsa03040	1.36026493
35	One carbon pool by folate_Homo sapiens_hsa00670	1.33339526
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33244312
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27076785
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.26055412
39	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.22392131
40	Purine metabolism_Homo sapiens_hsa00230	1.22391785
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.18537864
42	Peroxisome_Homo sapiens_hsa04146	1.17643929
43	RNA transport_Homo sapiens_hsa03013	1.14929933
44	Glutathione metabolism_Homo sapiens_hsa00480	1.13677927
45	Sulfur relay system_Homo sapiens_hsa04122	1.13616539
46	Phototransduction_Homo sapiens_hsa04744	1.09775708
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08669759
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07666182
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00391074
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.99048974
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.97765542
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.97600042
53	Folate biosynthesis_Homo sapiens_hsa00790	0.96761040
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91765796
55	Metabolic pathways_Homo sapiens_hsa01100	0.87780667
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82771593
57	Nicotine addiction_Homo sapiens_hsa05033	0.78904510
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78006713
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77444671
60	Carbon metabolism_Homo sapiens_hsa01200	0.75441150
61	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72996232
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.68066612
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64111087
64	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63917934
65	Fatty acid degradation_Homo sapiens_hsa00071	0.62810056
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62630266
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59511599
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.59241335
69	Oocyte meiosis_Homo sapiens_hsa04114	0.56645569
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.51498844
71	GABAergic synapse_Homo sapiens_hsa04727	0.50093324
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45812773
73	Olfactory transduction_Homo sapiens_hsa04740	0.45288125
74	Caffeine metabolism_Homo sapiens_hsa00232	0.42463730
75	Cell cycle_Homo sapiens_hsa04110	0.42254806
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40461512
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.38040715
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37521289
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37361362
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.37232015
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35767833
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34873948
83	Serotonergic synapse_Homo sapiens_hsa04726	0.34357578
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34238005
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34213455
86	Taste transduction_Homo sapiens_hsa04742	0.33589563
87	Amphetamine addiction_Homo sapiens_hsa05031	0.32220273
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31427717
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.30946437
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30821690
91	Alcoholism_Homo sapiens_hsa05034	0.28562502
92	Circadian entrainment_Homo sapiens_hsa04713	0.26685755
93	Morphine addiction_Homo sapiens_hsa05032	0.25381508
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.24436347
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24165723
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23869387
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.23388234
98	Insulin secretion_Homo sapiens_hsa04911	0.20829780
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.20165036
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.19682177

SPIN2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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