SPIN2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.89229441
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87186969
3protein complex biogenesis (GO:0070271)4.77360445
4ATP synthesis coupled proton transport (GO:0015986)4.72839566
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.72839566
6mitochondrial respiratory chain complex assembly (GO:0033108)4.59761761
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58078593
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.44337971
9NADH dehydrogenase complex assembly (GO:0010257)4.44337971
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.44337971
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.35255834
12respiratory electron transport chain (GO:0022904)4.11391605
13proteasome assembly (GO:0043248)4.10537846
14chaperone-mediated protein transport (GO:0072321)4.09390074
15electron transport chain (GO:0022900)4.07033476
16cullin deneddylation (GO:0010388)3.76161972
17respiratory chain complex IV assembly (GO:0008535)3.65498727
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60673130
19protein deneddylation (GO:0000338)3.60521366
20cytochrome complex assembly (GO:0017004)3.60090522
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42605521
22DNA double-strand break processing (GO:0000729)3.40519351
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36115020
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36115020
25pseudouridine synthesis (GO:0001522)3.34305606
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30716316
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25595104
28protein-cofactor linkage (GO:0018065)3.24480160
29metallo-sulfur cluster assembly (GO:0031163)3.21778980
30iron-sulfur cluster assembly (GO:0016226)3.21778980
31protein targeting to mitochondrion (GO:0006626)3.19645336
32termination of RNA polymerase III transcription (GO:0006386)3.18375064
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.18375064
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16575398
35water-soluble vitamin biosynthetic process (GO:0042364)3.14800318
36establishment of protein localization to mitochondrion (GO:0072655)3.12495281
37pyrimidine nucleotide catabolic process (GO:0006244)3.09781376
38ubiquinone biosynthetic process (GO:0006744)3.06636503
39hydrogen ion transmembrane transport (GO:1902600)3.04955939
40establishment of integrated proviral latency (GO:0075713)3.04057908
41regulation of mitotic spindle checkpoint (GO:1903504)3.02450280
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02450280
43regulation of mitochondrial translation (GO:0070129)3.01290596
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01042174
45protein localization to mitochondrion (GO:0070585)2.99608074
46sequestering of actin monomers (GO:0042989)2.99097950
47regulation of cellular amino acid metabolic process (GO:0006521)2.98480703
48ATP biosynthetic process (GO:0006754)2.97066467
49inositol phosphate catabolic process (GO:0071545)2.95486085
50mannosylation (GO:0097502)2.92229654
51centriole replication (GO:0007099)2.92046010
52negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91006163
53oxidative phosphorylation (GO:0006119)2.90491596
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90236146
55purine nucleobase biosynthetic process (GO:0009113)2.89692958
56replication fork processing (GO:0031297)2.87993189
57purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87615189
58peptidyl-histidine modification (GO:0018202)2.87600853
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87277599
60regulation of cilium movement (GO:0003352)2.86431289
61base-excision repair, AP site formation (GO:0006285)2.86262953
62inner mitochondrial membrane organization (GO:0007007)2.82171801
63preassembly of GPI anchor in ER membrane (GO:0016254)2.82066515
64proton transport (GO:0015992)2.77641071
65ubiquinone metabolic process (GO:0006743)2.77639743
66xenobiotic catabolic process (GO:0042178)2.77486348
67cellular ketone body metabolic process (GO:0046950)2.77351307
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76284968
69inositol phosphate dephosphorylation (GO:0046855)2.74763194
70phosphorylated carbohydrate dephosphorylation (GO:0046838)2.74763194
71GMP metabolic process (GO:0046037)2.74546487
72rRNA modification (GO:0000154)2.73630161
73GPI anchor biosynthetic process (GO:0006506)2.72736883
74branched-chain amino acid catabolic process (GO:0009083)2.72303475
75hydrogen transport (GO:0006818)2.72097298
76negative regulation of membrane potential (GO:0045837)2.71775906
77platelet dense granule organization (GO:0060155)2.71499637
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71369179
79tRNA processing (GO:0008033)2.70031206
80deoxyribonucleotide catabolic process (GO:0009264)2.69781582
81positive regulation of growth hormone secretion (GO:0060124)2.69634628
82spliceosomal snRNP assembly (GO:0000387)2.69304120
83guanosine-containing compound biosynthetic process (GO:1901070)2.69249314
84behavioral response to nicotine (GO:0035095)2.68456409
85L-methionine salvage (GO:0071267)2.67650025
86L-methionine biosynthetic process (GO:0071265)2.67650025
87amino acid salvage (GO:0043102)2.67650025
88positive regulation of mitochondrial fission (GO:0090141)2.65685308
89chromatin remodeling at centromere (GO:0031055)2.65481437
90regulation of helicase activity (GO:0051095)2.63142879
91negative regulation of ligase activity (GO:0051352)2.63043044
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63043044
93C-terminal protein lipidation (GO:0006501)2.62576629
94aldehyde catabolic process (GO:0046185)2.62216355
95mitochondrial transport (GO:0006839)2.61547461
96negative regulation of cation channel activity (GO:2001258)2.60457254
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.58536846
98deoxyribose phosphate catabolic process (GO:0046386)2.57051342
99negative regulation of heart rate (GO:0010459)2.56630835
100GTP biosynthetic process (GO:0006183)2.56279518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78352397
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.22420531
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.21486442
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.76571397
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51679556
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44216810
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34354010
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.09941543
9SRF_21415370_ChIP-Seq_HL-1_Mouse2.98354235
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91550556
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82269263
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59940342
13VDR_23849224_ChIP-Seq_CD4+_Human2.56655511
14ELK1_19687146_ChIP-ChIP_HELA_Human2.55353267
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.47038169
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.39053930
17ZNF274_21170338_ChIP-Seq_K562_Hela2.28643968
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26167315
19FOXP3_21729870_ChIP-Seq_TREG_Human2.25796644
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24461036
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14945271
22VDR_22108803_ChIP-Seq_LS180_Human2.12343029
23IGF1R_20145208_ChIP-Seq_DFB_Human2.12068417
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08177790
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01823296
26GABP_19822575_ChIP-Seq_HepG2_Human1.95703219
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94467387
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94280479
29EWS_26573619_Chip-Seq_HEK293_Human1.87468747
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87266422
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78512254
32DCP1A_22483619_ChIP-Seq_HELA_Human1.75253721
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73826577
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73127033
35MYC_18940864_ChIP-ChIP_HL60_Human1.62852146
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62720833
37TAF15_26573619_Chip-Seq_HEK293_Human1.61512787
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60738914
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57272960
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56287621
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56053297
42TTF2_22483619_ChIP-Seq_HELA_Human1.55535575
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54752469
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.53445729
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51765582
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49020491
47XRN2_22483619_ChIP-Seq_HELA_Human1.48340818
48FUS_26573619_Chip-Seq_HEK293_Human1.47101377
49HTT_18923047_ChIP-ChIP_STHdh_Human1.41078150
50TP53_22573176_ChIP-Seq_HFKS_Human1.32184957
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31310902
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25593135
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23688419
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23611924
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23397774
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21372623
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20945945
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.20138427
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19952561
60E2F7_22180533_ChIP-Seq_HELA_Human1.18140760
61IRF1_19129219_ChIP-ChIP_H3396_Human1.16965397
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14615478
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14353460
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12982685
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12923027
66P300_19829295_ChIP-Seq_ESCs_Human1.12516566
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11542382
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10957477
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10771770
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10434217
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09885934
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02776284
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98199134
74GBX2_23144817_ChIP-Seq_PC3_Human0.98115800
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98080001
76MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97206533
77MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96787559
78KDM5A_27292631_Chip-Seq_BREAST_Human0.96262397
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.95483106
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94948972
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94804854
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.94587105
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94346333
84* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93105042
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92780344
86ER_23166858_ChIP-Seq_MCF-7_Human0.92405889
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92140958
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91477377
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91062548
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90029685
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89081727
92CIITA_25753668_ChIP-Seq_RAJI_Human0.88541956
93AR_20517297_ChIP-Seq_VCAP_Human0.87896624
94EZH2_22144423_ChIP-Seq_EOC_Human0.87460612
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87335641
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85856976
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84945576
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82234294
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81536905
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79681521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.51068924
2MP0008058_abnormal_DNA_repair3.34167313
3MP0002736_abnormal_nociception_after3.20145277
4MP0001968_abnormal_touch/_nociception2.81181341
5MP0003122_maternal_imprinting2.76651162
6MP0004147_increased_porphyrin_level2.64661850
7MP0006072_abnormal_retinal_apoptosis2.56512584
8MP0003787_abnormal_imprinting2.54042697
9MP0003011_delayed_dark_adaptation2.45834177
10MP0002102_abnormal_ear_morphology2.33335251
11MP0003121_genomic_imprinting2.14243153
12MP0002837_dystrophic_cardiac_calcinosis2.11876227
13MP0009697_abnormal_copulation2.11348267
14MP0001984_abnormal_olfaction2.10505539
15MP0006036_abnormal_mitochondrial_physio2.10044819
16MP0010094_abnormal_chromosome_stability2.08511358
17MP0006276_abnormal_autonomic_nervous2.07035624
18MP0008877_abnormal_DNA_methylation1.91743919
19MP0001905_abnormal_dopamine_level1.91536755
20MP0005253_abnormal_eye_physiology1.88618425
21MP0009046_muscle_twitch1.88269302
22MP0003880_abnormal_central_pattern1.87287984
23MP0003186_abnormal_redox_activity1.84732188
24MP0003786_premature_aging1.73216744
25MP0006035_abnormal_mitochondrial_morpho1.68545037
26MP0008872_abnormal_physiological_respon1.68511653
27MP0002272_abnormal_nervous_system1.61330819
28MP0001188_hyperpigmentation1.59617809
29MP0002938_white_spotting1.57264584
30MP0005551_abnormal_eye_electrophysiolog1.56379403
31MP0003123_paternal_imprinting1.55897259
32MP0003693_abnormal_embryo_hatching1.55618234
33MP0004957_abnormal_blastocyst_morpholog1.55047488
34MP0005084_abnormal_gallbladder_morpholo1.55040450
35MP0004133_heterotaxia1.53353903
36MP0008789_abnormal_olfactory_epithelium1.47190566
37MP0000372_irregular_coat_pigmentation1.46317087
38MP0009745_abnormal_behavioral_response1.43087256
39MP0008995_early_reproductive_senescence1.37978638
40MP0004142_abnormal_muscle_tone1.33442238
41MP0006292_abnormal_olfactory_placode1.28584788
42MP0003718_maternal_effect1.28440967
43MP0003137_abnormal_impulse_conducting1.24384635
44MP0005394_taste/olfaction_phenotype1.24230299
45MP0005499_abnormal_olfactory_system1.24230299
46MP0000647_abnormal_sebaceous_gland1.23754593
47MP0008932_abnormal_embryonic_tissue1.22294109
48MP0003567_abnormal_fetal_cardiomyocyte1.21627485
49MP0001661_extended_life_span1.21100899
50MP0005464_abnormal_platelet_physiology1.18262029
51MP0005220_abnormal_exocrine_pancreas1.18006618
52MP0003806_abnormal_nucleotide_metabolis1.17906752
53MP0004145_abnormal_muscle_electrophysio1.16716616
54MP0010386_abnormal_urinary_bladder1.12682875
55MP0008875_abnormal_xenobiotic_pharmacok1.11595168
56MP0002751_abnormal_autonomic_nervous1.11298333
57MP0001970_abnormal_pain_threshold1.11224348
58MP0003111_abnormal_nucleus_morphology1.09010029
59MP0002734_abnormal_mechanical_nocicepti1.08899892
60MP0002638_abnormal_pupillary_reflex1.08321812
61MP0002572_abnormal_emotion/affect_behav1.08136749
62MP0002067_abnormal_sensory_capabilities1.04580805
63MP0002876_abnormal_thyroid_physiology1.04389979
64MP0000358_abnormal_cell_content/1.04384056
65MP0002735_abnormal_chemical_nociception1.04226828
66MP0004270_analgesia1.01982956
67MP0004859_abnormal_synaptic_plasticity1.00444158
68MP0002160_abnormal_reproductive_system1.00429002
69MP0005645_abnormal_hypothalamus_physiol0.98880140
70MP0001293_anophthalmia0.97397780
71MP0004085_abnormal_heartbeat0.97124258
72MP0002557_abnormal_social/conspecific_i0.96911143
73MP0001919_abnormal_reproductive_system0.95776154
74MP0004924_abnormal_behavior0.95622732
75MP0005386_behavior/neurological_phenoty0.95622732
76MP0003635_abnormal_synaptic_transmissio0.94361889
77MP0002064_seizures0.92552407
78MP0005410_abnormal_fertilization0.92454306
79MP0001727_abnormal_embryo_implantation0.91962167
80MP0000631_abnormal_neuroendocrine_gland0.91067982
81MP0002733_abnormal_thermal_nociception0.90719026
82MP0004215_abnormal_myocardial_fiber0.90166260
83MP0005646_abnormal_pituitary_gland0.90062915
84MP0005389_reproductive_system_phenotype0.88819705
85MP0000427_abnormal_hair_cycle0.87506282
86MP0008007_abnormal_cellular_replicative0.86773613
87MP0002210_abnormal_sex_determination0.86090881
88MP0005332_abnormal_amino_acid0.83833089
89MP0008775_abnormal_heart_ventricle0.83449989
90MP0001929_abnormal_gametogenesis0.82407575
91MP0002063_abnormal_learning/memory/cond0.80725854
92MP0005423_abnormal_somatic_nervous0.80554554
93MP0005391_vision/eye_phenotype0.78934742
94MP0002184_abnormal_innervation0.78718274
95MP0002752_abnormal_somatic_nervous0.77554752
96MP0005535_abnormal_body_temperature0.77456581
97MP0000653_abnormal_sex_gland0.75169311
98MP0001764_abnormal_homeostasis0.74973755
99MP0002693_abnormal_pancreas_physiology0.72341888
100MP0003077_abnormal_cell_cycle0.72313775

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.90138957
2Abnormal mitochondria in muscle tissue (HP:0008316)4.57837517
3Acute encephalopathy (HP:0006846)4.49927120
4Mitochondrial inheritance (HP:0001427)4.40318477
5Progressive macrocephaly (HP:0004481)4.21123904
6Increased CSF lactate (HP:0002490)4.06785501
7Hepatocellular necrosis (HP:0001404)3.89676795
83-Methylglutaconic aciduria (HP:0003535)3.84062299
9Hepatic necrosis (HP:0002605)3.72077446
10Renal Fanconi syndrome (HP:0001994)3.47384929
11Increased hepatocellular lipid droplets (HP:0006565)3.41560378
12Methylmalonic acidemia (HP:0002912)3.38795236
13Cerebral edema (HP:0002181)3.34990037
14Lipid accumulation in hepatocytes (HP:0006561)3.20399033
15Methylmalonic aciduria (HP:0012120)3.05973603
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94314289
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94314289
18Lactic acidosis (HP:0003128)2.92839172
19Increased intramyocellular lipid droplets (HP:0012240)2.88999788
20Increased serum lactate (HP:0002151)2.88027960
21Abnormality of the heme biosynthetic pathway (HP:0010472)2.80164493
22Respiratory failure (HP:0002878)2.68548671
23Hyperglycinemia (HP:0002154)2.64599607
24Molar tooth sign on MRI (HP:0002419)2.62163165
25Abnormality of midbrain morphology (HP:0002418)2.62163165
26Pancreatic islet-cell hyperplasia (HP:0004510)2.58510418
27Optic disc pallor (HP:0000543)2.46056453
28Hypothermia (HP:0002045)2.39413568
29Type I transferrin isoform profile (HP:0003642)2.37613291
30Increased muscle lipid content (HP:0009058)2.37474248
31Pancreatic cysts (HP:0001737)2.37271456
32Nephrogenic diabetes insipidus (HP:0009806)2.37047628
33Medial flaring of the eyebrow (HP:0010747)2.36306235
34Abnormality of alanine metabolism (HP:0010916)2.35353302
35Hyperalaninemia (HP:0003348)2.35353302
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35353302
37Exercise intolerance (HP:0003546)2.34956026
38Abnormal protein glycosylation (HP:0012346)2.32037513
39Abnormal glycosylation (HP:0012345)2.32037513
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32037513
41Abnormal protein N-linked glycosylation (HP:0012347)2.32037513
42Lethargy (HP:0001254)2.30736739
43Congenital, generalized hypertrichosis (HP:0004540)2.29802286
44Exertional dyspnea (HP:0002875)2.29587899
45Gait imbalance (HP:0002141)2.27477362
46Pancreatic fibrosis (HP:0100732)2.27315513
47Aplastic anemia (HP:0001915)2.25809259
48Abnormality of endocrine pancreas physiology (HP:0012093)2.24638471
49Abnormality of the pancreatic islet cells (HP:0006476)2.24638471
50True hermaphroditism (HP:0010459)2.22030651
51Abnormality of methionine metabolism (HP:0010901)2.19915312
52Congenital primary aphakia (HP:0007707)2.19773627
53Respiratory difficulties (HP:0002880)2.14397878
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12954126
55Dicarboxylic aciduria (HP:0003215)2.12954126
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12565099
57Abnormality of the anterior horn cell (HP:0006802)2.12067121
58Degeneration of anterior horn cells (HP:0002398)2.12067121
59Emotional lability (HP:0000712)2.11673815
60Ketoacidosis (HP:0001993)2.11057940
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09666156
62Abnormality of serine family amino acid metabolism (HP:0010894)2.06989815
63Abnormality of glycine metabolism (HP:0010895)2.06989815
64X-linked dominant inheritance (HP:0001423)2.05048740
65Abnormality of renal resorption (HP:0011038)2.05036574
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.04396896
67Cerebral hypomyelination (HP:0006808)1.99841794
68Severe combined immunodeficiency (HP:0004430)1.98153467
69Prominent metopic ridge (HP:0005487)1.97794232
70Nephronophthisis (HP:0000090)1.96039277
71Type II lissencephaly (HP:0007260)1.95371760
72Hyperinsulinemic hypoglycemia (HP:0000825)1.94654574
73Petechiae (HP:0000967)1.94626436
74CNS demyelination (HP:0007305)1.94271855
75Limb dystonia (HP:0002451)1.92452551
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91539297
77Muscular hypotonia of the trunk (HP:0008936)1.90884535
78Abnormality of serum amino acid levels (HP:0003112)1.90617511
79Hypoproteinemia (HP:0003075)1.89156814
80Leukodystrophy (HP:0002415)1.87740576
81Hyperglycinuria (HP:0003108)1.87485215
82Disproportionate short-trunk short stature (HP:0003521)1.84169360
83Abolished electroretinogram (ERG) (HP:0000550)1.83648936
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83506955
85CNS hypomyelination (HP:0003429)1.82816838
86Reduced antithrombin III activity (HP:0001976)1.82522368
87Abnormal rod and cone electroretinograms (HP:0008323)1.82238134
88Polyphagia (HP:0002591)1.80806665
89Abnormality of the metopic suture (HP:0005556)1.80178787
90Myokymia (HP:0002411)1.79451779
91Retinal dysplasia (HP:0007973)1.77578288
92Postnatal microcephaly (HP:0005484)1.77274840
93Abnormality of the labia minora (HP:0012880)1.76868131
94Abnormality of vitamin B metabolism (HP:0004340)1.76735121
95Thyroid-stimulating hormone excess (HP:0002925)1.75075166
96Abnormality of chromosome stability (HP:0003220)1.74758104
97Hypoglycemic coma (HP:0001325)1.73564187
98Glycosuria (HP:0003076)1.72699528
99Abnormality of urine glucose concentration (HP:0011016)1.72699528
100Severe muscular hypotonia (HP:0006829)1.72144491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.93004711
2VRK22.68881520
3NUAK12.67055207
4WNK32.61515820
5BCKDK2.55350065
6STK162.52968526
7SRPK12.32711529
8FRK2.03153725
9PLK42.02763446
10MAP2K71.91518818
11MAP3K41.91314429
12BMPR1B1.85819120
13CDC71.83290631
14EIF2AK31.82333781
15MAPK131.70611930
16TRIM281.61543637
17VRK11.58417470
18TNIK1.56804048
19MKNK21.55159594
20RPS6KA41.52763850
21CASK1.52527591
22DYRK21.52301796
23PLK31.50428351
24DYRK31.50226893
25KDR1.49974692
26MKNK11.45119480
27BUB11.42474984
28MST41.35417450
29PDK21.35248571
30EIF2AK11.32746640
31PIM21.32205168
32CCNB11.30369232
33PLK21.29402878
34GRK11.19639411
35LIMK11.17916743
36AKT31.17492776
37CSNK1G31.15280899
38MAP3K121.15157970
39CAMKK21.14604176
40CSNK1G21.14027369
41MARK11.10761573
42CSNK1G11.05478861
43ADRBK21.05066283
44NEK11.03327115
45TESK21.02587848
46ZAK1.00189125
47BCR0.99635043
48TESK10.97093025
49EPHA40.96331319
50ERBB30.94860014
51PLK10.90777074
52FLT30.90516991
53NME10.87847500
54DAPK10.86363227
55BRAF0.83658756
56TAF10.83202637
57ATR0.80992676
58PHKG10.78361023
59PHKG20.78361023
60TXK0.77775924
61ILK0.74583069
62TTK0.73632645
63PRKCG0.73309347
64GRK50.72713603
65MATK0.71805467
66INSRR0.71221750
67MYLK0.70618975
68MINK10.68595960
69PAK30.68424303
70PRKCE0.66380269
71TEC0.66306766
72CSNK1A1L0.66177067
73NME20.65002728
74NTRK10.61897459
75PINK10.61357475
76RPS6KA50.57865576
77ADRBK10.54577210
78BRSK20.53382571
79RAF10.50621287
80AURKA0.50054257
81CSNK2A20.49015376
82AURKB0.46697414
83ATM0.46180158
84BMX0.45482812
85PAK10.45353534
86CAMK2A0.44267270
87CDK140.43375242
88WEE10.42935673
89CSNK2A10.41807385
90CAMK2D0.40486332
91PRKACA0.39678164
92MAP3K60.39200943
93TSSK60.38630923
94BRSK10.34659868
95CSNK1A10.34463811
96DYRK1A0.33961239
97DAPK30.33072552
98MAP3K50.32354774
99CDK80.30842360
100PRKCA0.29443462

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.96186092
2Parkinsons disease_Homo sapiens_hsa050123.46690866
3Proteasome_Homo sapiens_hsa030503.42335326
4Protein export_Homo sapiens_hsa030603.07248088
5Mismatch repair_Homo sapiens_hsa034302.74096827
6RNA polymerase_Homo sapiens_hsa030202.59239785
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33290425
8Huntingtons disease_Homo sapiens_hsa050162.30244080
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16442554
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14661795
11Alzheimers disease_Homo sapiens_hsa050102.14596340
12Fatty acid elongation_Homo sapiens_hsa000622.04802962
13Homologous recombination_Homo sapiens_hsa034401.98186051
14Ribosome_Homo sapiens_hsa030101.97750285
15DNA replication_Homo sapiens_hsa030301.81498649
16Fanconi anemia pathway_Homo sapiens_hsa034601.81149341
17Non-homologous end-joining_Homo sapiens_hsa034501.74745123
18Propanoate metabolism_Homo sapiens_hsa006401.70933426
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68880995
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67058006
21Base excision repair_Homo sapiens_hsa034101.66851774
22Nucleotide excision repair_Homo sapiens_hsa034201.65891068
23Sulfur metabolism_Homo sapiens_hsa009201.62217755
24Butanoate metabolism_Homo sapiens_hsa006501.61103827
25Basal transcription factors_Homo sapiens_hsa030221.54553003
26Cardiac muscle contraction_Homo sapiens_hsa042601.53829943
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53826417
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53105574
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51394415
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44165547
31RNA degradation_Homo sapiens_hsa030181.43331349
32Regulation of autophagy_Homo sapiens_hsa041401.42786943
33Pyrimidine metabolism_Homo sapiens_hsa002401.38671885
34Spliceosome_Homo sapiens_hsa030401.36026493
35One carbon pool by folate_Homo sapiens_hsa006701.33339526
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33244312
37Collecting duct acid secretion_Homo sapiens_hsa049661.27076785
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26055412
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22392131
40Purine metabolism_Homo sapiens_hsa002301.22391785
41Fatty acid metabolism_Homo sapiens_hsa012121.18537864
42Peroxisome_Homo sapiens_hsa041461.17643929
43RNA transport_Homo sapiens_hsa030131.14929933
44Glutathione metabolism_Homo sapiens_hsa004801.13677927
45Sulfur relay system_Homo sapiens_hsa041221.13616539
46Phototransduction_Homo sapiens_hsa047441.09775708
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08669759
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.07666182
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.00391074
50Pyruvate metabolism_Homo sapiens_hsa006200.99048974
51Steroid biosynthesis_Homo sapiens_hsa001000.97765542
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97600042
53Folate biosynthesis_Homo sapiens_hsa007900.96761040
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.91765796
55Metabolic pathways_Homo sapiens_hsa011000.87780667
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82771593
57Nicotine addiction_Homo sapiens_hsa050330.78904510
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78006713
59beta-Alanine metabolism_Homo sapiens_hsa004100.77444671
60Carbon metabolism_Homo sapiens_hsa012000.75441150
61Synaptic vesicle cycle_Homo sapiens_hsa047210.72996232
62Tryptophan metabolism_Homo sapiens_hsa003800.68066612
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64111087
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63917934
65Fatty acid degradation_Homo sapiens_hsa000710.62810056
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62630266
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59511599
68Biosynthesis of amino acids_Homo sapiens_hsa012300.59241335
69Oocyte meiosis_Homo sapiens_hsa041140.56645569
70Primary immunodeficiency_Homo sapiens_hsa053400.51498844
71GABAergic synapse_Homo sapiens_hsa047270.50093324
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45812773
73Olfactory transduction_Homo sapiens_hsa047400.45288125
74Caffeine metabolism_Homo sapiens_hsa002320.42463730
75Cell cycle_Homo sapiens_hsa041100.42254806
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40461512
77Tyrosine metabolism_Homo sapiens_hsa003500.38040715
78Vibrio cholerae infection_Homo sapiens_hsa051100.37521289
79N-Glycan biosynthesis_Homo sapiens_hsa005100.37361362
80Nitrogen metabolism_Homo sapiens_hsa009100.37232015
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35767833
82Chemical carcinogenesis_Homo sapiens_hsa052040.34873948
83Serotonergic synapse_Homo sapiens_hsa047260.34357578
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34238005
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34213455
86Taste transduction_Homo sapiens_hsa047420.33589563
87Amphetamine addiction_Homo sapiens_hsa050310.32220273
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31427717
89Dopaminergic synapse_Homo sapiens_hsa047280.30946437
90Arginine and proline metabolism_Homo sapiens_hsa003300.30821690
91Alcoholism_Homo sapiens_hsa050340.28562502
92Circadian entrainment_Homo sapiens_hsa047130.26685755
93Morphine addiction_Homo sapiens_hsa050320.25381508
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24436347
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24165723
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23869387
97Selenocompound metabolism_Homo sapiens_hsa004500.23388234
98Insulin secretion_Homo sapiens_hsa049110.20829780
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20165036
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19682177

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