ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	5.30250483
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.14435050
3	presynaptic membrane organization (GO:0097090)	4.54479645
4	neuron cell-cell adhesion (GO:0007158)	4.27481483
5	nucleobase catabolic process (GO:0046113)	4.18748772
6	gamma-aminobutyric acid transport (GO:0015812)	3.97061769
7	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.94061008
8	glutamate secretion (GO:0014047)	3.75343522
9	establishment of mitochondrion localization (GO:0051654)	3.69948804
10	synaptic vesicle exocytosis (GO:0016079)	3.60239548
11	neuron recognition (GO:0008038)	3.60109156
12	axonal fasciculation (GO:0007413)	3.56742752
13	synaptic vesicle maturation (GO:0016188)	3.48798501
14	vocalization behavior (GO:0071625)	3.40189361
15	pre-miRNA processing (GO:0031054)	3.30034901
16	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.30017063
17	positive regulation of mitochondrial fission (GO:0090141)	3.29557349
18	postsynaptic membrane organization (GO:0001941)	3.28726762
19	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.14631956
20	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.14631956
21	regulation of synaptic vesicle exocytosis (GO:2000300)	3.13202272
22	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.05818463
23	neurotransmitter secretion (GO:0007269)	3.05680017
24	dendrite morphogenesis (GO:0048813)	3.05632488
25	histone H2A acetylation (GO:0043968)	2.98406473
26	protein localization to synapse (GO:0035418)	2.97179683
27	dendritic spine morphogenesis (GO:0060997)	2.96255186
28	L-serine metabolic process (GO:0006563)	2.91297715
29	mitochondrion transport along microtubule (GO:0047497)	2.87290672
30	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.87290672
31	organelle transport along microtubule (GO:0072384)	2.81562174
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79053551
33	limb bud formation (GO:0060174)	2.78854251
34	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.78598504
35	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.76488737
36	central nervous system projection neuron axonogenesis (GO:0021952)	2.74207388
37	synapse assembly (GO:0007416)	2.72367598
38	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.69098069
39	amino acid import (GO:0043090)	2.67522064
40	righting reflex (GO:0060013)	2.66823996
41	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.66795976
42	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.65977243
43	vascular smooth muscle contraction (GO:0014829)	2.63502451
44	positive regulation of synapse assembly (GO:0051965)	2.60794764
45	neurotransmitter-gated ion channel clustering (GO:0072578)	2.60193630
46	regulation of development, heterochronic (GO:0040034)	2.58997486
47	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.58579306
48	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.55980277
49	Golgi to endosome transport (GO:0006895)	2.54374534
50	neurotransmitter transport (GO:0006836)	2.53170671
51	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.51586662
52	intraciliary transport (GO:0042073)	2.50124315
53	layer formation in cerebral cortex (GO:0021819)	2.49956331
54	regulation of neuron migration (GO:2001222)	2.47448214
55	sodium ion export (GO:0071436)	2.47179101
56	cerebral cortex neuron differentiation (GO:0021895)	2.46000006
57	regulation of synaptic vesicle transport (GO:1902803)	2.42669122
58	central nervous system neuron axonogenesis (GO:0021955)	2.41997924
59	microtubule-based transport (GO:0010970)	2.41590280
60	cytoskeleton-dependent intracellular transport (GO:0030705)	2.40067917
61	cholesterol biosynthetic process (GO:0006695)	2.39569482
62	establishment of vesicle localization (GO:0051650)	2.39114996
63	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.38567911
64	regulation of dendritic spine morphogenesis (GO:0061001)	2.37181762
65	neuronal ion channel clustering (GO:0045161)	2.35452117
66	stress granule assembly (GO:0034063)	2.34349688
67	dendritic spine organization (GO:0097061)	2.33862256
68	hippocampus development (GO:0021766)	2.32455255
69	acidic amino acid transport (GO:0015800)	2.32403741
70	establishment of synaptic vesicle localization (GO:0097480)	2.32330843
71	synaptic vesicle transport (GO:0048489)	2.32330843
72	regulation of telomere maintenance via telomerase (GO:0032210)	2.31909440
73	regulation of respiratory system process (GO:0044065)	2.27275769
74	regulation of neurotransmitter levels (GO:0001505)	2.26969708
75	axon cargo transport (GO:0008088)	2.25960506
76	nonmotile primary cilium assembly (GO:0035058)	2.24273932
77	establishment of integrated proviral latency (GO:0075713)	2.24191666
78	synaptic transmission, glutamatergic (GO:0035249)	2.23883601
79	regulation of feeding behavior (GO:0060259)	2.22706120
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.22349241
81	synapse organization (GO:0050808)	2.22281924
82	pyrimidine dimer repair (GO:0006290)	2.21534685
83	negative regulation of DNA recombination (GO:0045910)	2.21275798
84	neurofilament cytoskeleton organization (GO:0060052)	2.20554597
85	microtubule anchoring (GO:0034453)	2.20408437
86	vesicle transport along microtubule (GO:0047496)	2.19204784
87	ephrin receptor signaling pathway (GO:0048013)	2.18599659
88	regulation of neuronal synaptic plasticity (GO:0048168)	2.17184549
89	regulation of microtubule depolymerization (GO:0031114)	2.17020387
90	regulation of timing of cell differentiation (GO:0048505)	2.16310647
91	regulation of cofactor metabolic process (GO:0051193)	2.15630177
92	regulation of coenzyme metabolic process (GO:0051196)	2.15630177
93	neuron-neuron synaptic transmission (GO:0007270)	2.14787310
94	kidney morphogenesis (GO:0060993)	2.14633363
95	regulation of telomere maintenance (GO:0032204)	2.13956175
96	regulation of synapse assembly (GO:0051963)	2.11503809
97	startle response (GO:0001964)	2.11180772
98	dopamine biosynthetic process (GO:0042416)	2.09898383
99	regulation of mitochondrial fission (GO:0090140)	2.09741465
100	exploration behavior (GO:0035640)	2.09628143

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.91439736
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.82445143
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.16861267
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.06312952
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.05764619
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.03741058
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.78406096
8	FUS_26573619_Chip-Seq_HEK293_Human	2.48076591
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42196238
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39259454
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.38299509
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14990838
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.13410677
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.03145870
15	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.90371017
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.84481866
17	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.77974948
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.77945288
19	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.76432048
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76351107
21	EWS_26573619_Chip-Seq_HEK293_Human	1.73906573
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68531151
23	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64497704
24	P300_19829295_ChIP-Seq_ESCs_Human	1.58795017
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.57366799
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55327552
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54597295
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.50559608
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.46579347
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45208342
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44354471
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41485427
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38712404
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38602060
35	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.35318754
36	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.34225034
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33838813
38	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32161224
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31810685
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31222265
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30906192
42	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.30855369
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30525462
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28279620
45	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.28121749
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26528369
47	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.25913996
48	VDR_22108803_ChIP-Seq_LS180_Human	1.19960306
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19072098
50	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.17973068
51	STAT3_23295773_ChIP-Seq_U87_Human	1.17565133
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15912954
53	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15215075
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13032191
55	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.12714357
56	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.12352171
57	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12041379
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10262205
59	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.09550014
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08625048
61	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08512079
62	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08263347
63	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07748364
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07351642
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07311164
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07017063
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07017063
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06498464
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06222922
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.04958425
71	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.04880097
72	AR_25329375_ChIP-Seq_VCAP_Human	1.04503192
73	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.04223237
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03630018
75	TCF4_23295773_ChIP-Seq_U87_Human	1.03356533
76	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.02740803
77	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.01973038
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.01921897
79	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.01588347
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01428754
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00366811
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.00366811
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99965100
84	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99570119
85	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98616306
86	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.98220031
87	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97789165
88	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.97196235
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97063990
90	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96204754
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94296603
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.94214184
93	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.94060429
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.93360883
95	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.93141327
96	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.92870313
97	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.92830203
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92316294
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.91609811
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90170609

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.57983118
2	MP0004859_abnormal_synaptic_plasticity	3.27106323
3	MP0003890_abnormal_embryonic-extraembry	2.89412957
4	MP0005423_abnormal_somatic_nervous	2.84022225
5	MP0004270_analgesia	2.55000132
6	MP0002822_catalepsy	2.45672450
7	MP0003787_abnormal_imprinting	2.35545304
8	MP0003122_maternal_imprinting	2.34452555
9	MP0002102_abnormal_ear_morphology	2.33079761
10	MP0001984_abnormal_olfaction	2.15858933
11	MP0000778_abnormal_nervous_system	2.13835605
12	MP0001529_abnormal_vocalization	2.13327345
13	MP0005394_taste/olfaction_phenotype	2.12972049
14	MP0005499_abnormal_olfactory_system	2.12972049
15	MP0003635_abnormal_synaptic_transmissio	2.08748067
16	MP0003121_genomic_imprinting	1.90201505
17	MP0006276_abnormal_autonomic_nervous	1.74584464
18	MP0008789_abnormal_olfactory_epithelium	1.71083166
19	MP0001299_abnormal_eye_distance/	1.64262172
20	MP0009046_muscle_twitch	1.62986033
21	MP0002063_abnormal_learning/memory/cond	1.62929621
22	MP0000569_abnormal_digit_pigmentation	1.61801245
23	MP0002734_abnormal_mechanical_nocicepti	1.61396690
24	MP0002735_abnormal_chemical_nociception	1.60285891
25	MP0001486_abnormal_startle_reflex	1.60160244
26	MP0008877_abnormal_DNA_methylation	1.57481514
27	MP0009745_abnormal_behavioral_response	1.54662492
28	MP0004133_heterotaxia	1.46862538
29	MP0003941_abnormal_skin_development	1.45206724
30	MP0004811_abnormal_neuron_physiology	1.44425415
31	MP0000955_abnormal_spinal_cord	1.43997340
32	MP0002572_abnormal_emotion/affect_behav	1.43057249
33	MP0001293_anophthalmia	1.43009834
34	MP0002064_seizures	1.42034517
35	MP0002272_abnormal_nervous_system	1.42033987
36	MP0000566_synostosis	1.35796162
37	MP0002233_abnormal_nose_morphology	1.32648271
38	MP0002234_abnormal_pharynx_morphology	1.29823398
39	MP0009780_abnormal_chondrocyte_physiolo	1.27107565
40	MP0008058_abnormal_DNA_repair	1.26490448
41	MP0004142_abnormal_muscle_tone	1.24811858
42	MP0002184_abnormal_innervation	1.22760228
43	MP0005386_behavior/neurological_phenoty	1.22448867
44	MP0004924_abnormal_behavior	1.22448867
45	MP0002736_abnormal_nociception_after	1.22411196
46	MP0002882_abnormal_neuron_morphology	1.22045459
47	MP0001177_atelectasis	1.21980499
48	MP0003861_abnormal_nervous_system	1.20878804
49	MP0002751_abnormal_autonomic_nervous	1.20514716
50	MP0002909_abnormal_adrenal_gland	1.20259366
51	MP0002653_abnormal_ependyma_morphology	1.20122308
52	MP0003221_abnormal_cardiomyocyte_apopto	1.19631062
53	MP0000631_abnormal_neuroendocrine_gland	1.18810233
54	MP0002557_abnormal_social/conspecific_i	1.18093244
55	MP0002152_abnormal_brain_morphology	1.14041412
56	MP0002067_abnormal_sensory_capabilities	1.13278816
57	MP0003755_abnormal_palate_morphology	1.09294947
58	MP0001968_abnormal_touch/_nociception	1.08040028
59	MP0001188_hyperpigmentation	1.06863589
60	MP0005248_abnormal_Harderian_gland	1.06042401
61	MP0002090_abnormal_vision	1.05798778
62	MP0009672_abnormal_birth_weight	1.05487136
63	MP0006072_abnormal_retinal_apoptosis	1.03603372
64	MP0003718_maternal_effect	1.03590133
65	MP0009703_decreased_birth_body	1.01852252
66	MP0000049_abnormal_middle_ear	0.97666927
67	MP0003136_yellow_coat_color	0.97427832
68	MP0003937_abnormal_limbs/digits/tail_de	0.96451852
69	MP0002697_abnormal_eye_size	0.94185179
70	MP0000647_abnormal_sebaceous_gland	0.92822605
71	MP0003119_abnormal_digestive_system	0.91993815
72	MP0008569_lethality_at_weaning	0.91807850
73	MP0002638_abnormal_pupillary_reflex	0.91762641
74	MP0002084_abnormal_developmental_patter	0.91512307
75	MP0001346_abnormal_lacrimal_gland	0.91111948
76	MP0001286_abnormal_eye_development	0.91081718
77	MP0002066_abnormal_motor_capabilities/c	0.90330811
78	MP0006292_abnormal_olfactory_placode	0.89660996
79	MP0003385_abnormal_body_wall	0.89269458
80	MP0006035_abnormal_mitochondrial_morpho	0.88712286
81	MP0005551_abnormal_eye_electrophysiolog	0.86797865
82	MP0003935_abnormal_craniofacial_develop	0.86225806
83	MP0005645_abnormal_hypothalamus_physiol	0.85921457
84	MP0005253_abnormal_eye_physiology	0.85646296
85	MP0008932_abnormal_embryonic_tissue	0.85114807
86	MP0004197_abnormal_fetal_growth/weight/	0.83827870
87	MP0002752_abnormal_somatic_nervous	0.83533559
88	MP0003123_paternal_imprinting	0.83377810
89	MP0002069_abnormal_eating/drinking_beha	0.82652197
90	MP0003115_abnormal_respiratory_system	0.79378792
91	MP0000383_abnormal_hair_follicle	0.76943608
92	MP0002081_perinatal_lethality	0.75361168
93	MP0005391_vision/eye_phenotype	0.74888439
94	MP0001986_abnormal_taste_sensitivity	0.73717272
95	MP0001970_abnormal_pain_threshold	0.71630185
96	MP0010678_abnormal_skin_adnexa	0.70394489
97	MP0002092_abnormal_eye_morphology	0.70010933
98	MP0005623_abnormal_meninges_morphology	0.69698408
99	MP0002085_abnormal_embryonic_tissue	0.68978142
100	MP0002177_abnormal_outer_ear	0.68310288

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	3.49591404
2	Limb dystonia (HP:0002451)	3.06940402
3	Split foot (HP:0001839)	2.90701460
4	Hypoglycemic seizures (HP:0002173)	2.86713502
5	Abnormality of the labia minora (HP:0012880)	2.83173063
6	Focal motor seizures (HP:0011153)	2.75563083
7	Gait imbalance (HP:0002141)	2.74254778
8	Urinary urgency (HP:0000012)	2.67821540
9	Medulloblastoma (HP:0002885)	2.56878489
10	Medial flaring of the eyebrow (HP:0010747)	2.55462860
11	Sleep apnea (HP:0010535)	2.54555576
12	Drooling (HP:0002307)	2.53339166
13	Congenital primary aphakia (HP:0007707)	2.47982465
14	Vaginal atresia (HP:0000148)	2.45903294
15	Hypoglycemic coma (HP:0001325)	2.44753628
16	Bifid tongue (HP:0010297)	2.42976061
17	Genital tract atresia (HP:0001827)	2.42847488
18	Epileptiform EEG discharges (HP:0011182)	2.39488949
19	Hypsarrhythmia (HP:0002521)	2.38940568
20	EEG with generalized epileptiform discharges (HP:0011198)	2.38779439
21	Broad-based gait (HP:0002136)	2.32866189
22	Papillary thyroid carcinoma (HP:0002895)	2.30941640
23	Excessive salivation (HP:0003781)	2.28581400
24	Nephrogenic diabetes insipidus (HP:0009806)	2.28502924
25	Hyperinsulinemic hypoglycemia (HP:0000825)	2.24794863
26	Hand muscle atrophy (HP:0009130)	2.23904760
27	Abnormality of the metopic suture (HP:0005556)	2.21280476
28	Hyperglycinemia (HP:0002154)	2.20503570
29	Abnormal hair whorl (HP:0010721)	2.20296617
30	Hip dysplasia (HP:0001385)	2.18638100
31	Prominent metopic ridge (HP:0005487)	2.18368972
32	Midline defect of the nose (HP:0004122)	2.17476811
33	Limb-girdle muscle atrophy (HP:0003797)	2.15801153
34	Supernumerary spleens (HP:0009799)	2.14855941
35	Focal seizures (HP:0007359)	2.13566466
36	Atonic seizures (HP:0010819)	2.12579111
37	Intestinal atresia (HP:0011100)	2.09140764
38	Abnormality of the septum pellucidum (HP:0007375)	2.08670058
39	Pheochromocytoma (HP:0002666)	2.02981204
40	Epileptic encephalopathy (HP:0200134)	2.02607426
41	Septo-optic dysplasia (HP:0100842)	2.02566265
42	Amyotrophic lateral sclerosis (HP:0007354)	2.01749117
43	Hepatoblastoma (HP:0002884)	2.00907986
44	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.00016834
45	Poor coordination (HP:0002370)	1.98535940
46	Hammertoe (HP:0001765)	1.98489496
47	Myelomeningocele (HP:0002475)	1.97174698
48	Myokymia (HP:0002411)	1.96893835
49	Abnormality of the hip-girdle musculature (HP:0001445)	1.95222617
50	Abnormality of the musculature of the pelvis (HP:0001469)	1.95222617
51	Methylmalonic acidemia (HP:0002912)	1.93896990
52	Abnormal lung lobation (HP:0002101)	1.92715445
53	Limb hypertonia (HP:0002509)	1.92367653
54	Absent septum pellucidum (HP:0001331)	1.92070153
55	Specific learning disability (HP:0001328)	1.91475829
56	Failure to thrive in infancy (HP:0001531)	1.91307646
57	Lower limb asymmetry (HP:0100559)	1.90326678
58	Muscular hypotonia of the trunk (HP:0008936)	1.87595615
59	Short tibia (HP:0005736)	1.86328071
60	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.83875878
61	Hypoplasia of the brainstem (HP:0002365)	1.83875878
62	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.82833455
63	Absent eyebrow (HP:0002223)	1.81180667
64	Broad foot (HP:0001769)	1.80343556
65	Meningocele (HP:0002435)	1.79586514
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79410868
67	Ankle clonus (HP:0011448)	1.78789042
68	Cutaneous finger syndactyly (HP:0010554)	1.78691288
69	Generalized tonic-clonic seizures (HP:0002069)	1.78624657
70	Spastic gait (HP:0002064)	1.76828922
71	Lissencephaly (HP:0001339)	1.76217937
72	Postaxial hand polydactyly (HP:0001162)	1.75515525
73	Micropenis (HP:0000054)	1.75021317
74	Hyperventilation (HP:0002883)	1.72014451
75	Retinal dysplasia (HP:0007973)	1.71449131
76	Polyphagia (HP:0002591)	1.70937672
77	Spastic diplegia (HP:0001264)	1.70117630
78	Truncal ataxia (HP:0002078)	1.68969345
79	Abnormality of the lower motor neuron (HP:0002366)	1.68326584
80	Chronic hepatic failure (HP:0100626)	1.66260754
81	Omphalocele (HP:0001539)	1.65782690
82	Neoplasm of the heart (HP:0100544)	1.64796192
83	Dyskinesia (HP:0100660)	1.64681990
84	Nephroblastoma (Wilms tumor) (HP:0002667)	1.64268770
85	Spastic tetraplegia (HP:0002510)	1.62403717
86	Cutaneous syndactyly (HP:0012725)	1.61762645
87	Renal hypoplasia (HP:0000089)	1.61593519
88	Spinal muscular atrophy (HP:0007269)	1.59751603
89	Lower limb muscle weakness (HP:0007340)	1.59330203
90	Abnormality of the astrocytes (HP:0100707)	1.58363504
91	Astrocytoma (HP:0009592)	1.58363504
92	Scrotal hypoplasia (HP:0000046)	1.57739883
93	Termporal pattern (HP:0011008)	1.57214333
94	Insidious onset (HP:0003587)	1.57214333
95	Hypoplasia of the corpus callosum (HP:0002079)	1.57061002
96	Gastroesophageal reflux (HP:0002020)	1.56883509
97	Ependymoma (HP:0002888)	1.56592902
98	CNS hypomyelination (HP:0003429)	1.56302898
99	Optic nerve hypoplasia (HP:0000609)	1.56170773
100	Increased circulating renin level (HP:0000848)	1.56031852

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.82351865
2	MAP3K4	3.54661600
3	MAP2K7	3.15626521
4	EPHA4	2.73602604
5	BCR	2.64014042
6	CASK	2.55378474
7	MAP4K2	2.55081144
8	SRPK1	2.52216083
9	WNK3	2.47731880
10	EPHA3	2.39331585
11	TRIM28	2.29945958
12	BRD4	2.28510780
13	NTRK2	2.04186806
14	FGFR2	1.97701913
15	ERBB3	1.86980415
16	TSSK6	1.82557660
17	LATS1	1.80925801
18	MKNK1	1.69866386
19	CSNK1G2	1.59896770
20	FER	1.51228938
21	CSNK1A1L	1.50145113
22	MKNK2	1.48957512
23	TNIK	1.43788219
24	CSNK1G3	1.41311739
25	MAP2K4	1.38795808
26	CSNK1G1	1.38324482
27	STK38L	1.37611331
28	UHMK1	1.34764362
29	DYRK2	1.34352155
30	MAPK13	1.25842230
31	NEK6	1.25559246
32	RPS6KA4	1.21870812
33	PAK3	1.13013342
34	PHKG1	1.11467676
35	PHKG2	1.11467676
36	PLK2	1.07160787
37	PKN2	1.05448027
38	CDK5	0.99690150
39	PNCK	0.99228439
40	EPHB1	0.98946094
41	YES1	0.95897626
42	SIK2	0.95805799
43	INSRR	0.95613892
44	OXSR1	0.94552219
45	ERBB4	0.92870268
46	BRSK1	0.92364462
47	CDK19	0.89131924
48	EIF2AK1	0.88559384
49	MINK1	0.85120363
50	DYRK1A	0.84145213
51	NTRK3	0.83333662
52	BRSK2	0.83111748
53	CDK3	0.82890701
54	FGFR1	0.81521335
55	EIF2AK3	0.80215052
56	PLK3	0.77783037
57	AKT3	0.77242782
58	PINK1	0.76483137
59	FRK	0.73377070
60	LATS2	0.71993517
61	MAP3K9	0.71516338
62	PRKCE	0.70001135
63	STK39	0.69899409
64	ALK	0.67444204
65	STK38	0.66947444
66	CDK18	0.66300611
67	CAMK2B	0.66212983
68	CDC7	0.66137966
69	TTK	0.64394065
70	CDK14	0.64378821
71	PRKCG	0.62880311
72	MAP3K6	0.62142692
73	DYRK3	0.60917605
74	PRKAA1	0.60162359
75	RET	0.59532581
76	CDK15	0.59343629
77	PAK6	0.59084671
78	CAMK2A	0.57292970
79	PRKD3	0.55490734
80	CSNK1E	0.55352682
81	SGK494	0.55072896
82	SGK223	0.55072896
83	MAP3K10	0.54769303
84	SIK3	0.53879093
85	KSR1	0.52155776
86	CDK11A	0.50201461
87	CSNK1D	0.49289776
88	PDGFRA	0.47626961
89	SGK2	0.45370575
90	CAMKK2	0.44480933
91	DAPK2	0.43980673
92	NUAK1	0.43672881
93	PLK1	0.43266474
94	ATM	0.42896066
95	MAPK10	0.42270913
96	PKN1	0.41716024
97	MAPK9	0.40453946
98	CDK1	0.40172119
99	GSK3B	0.39821346
100	STK11	0.37772696

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.10459197
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.93688290
3	GABAergic synapse_Homo sapiens_hsa04727	2.57955486
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.54442601
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.28038078
6	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.10217610
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.03844980
8	Protein export_Homo sapiens_hsa03060	2.02310955
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.87234371
10	Circadian rhythm_Homo sapiens_hsa04710	1.76174277
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.66474568
12	Butanoate metabolism_Homo sapiens_hsa00650	1.58438474
13	Oocyte meiosis_Homo sapiens_hsa04114	1.55813885
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.52953155
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.48698774
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45194343
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.44506704
18	Amphetamine addiction_Homo sapiens_hsa05031	1.44166832
19	Morphine addiction_Homo sapiens_hsa05032	1.44130056
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.42007590
21	Dopaminergic synapse_Homo sapiens_hsa04728	1.39683469
22	Taste transduction_Homo sapiens_hsa04742	1.39529272
23	Basal transcription factors_Homo sapiens_hsa03022	1.38876724
24	Cocaine addiction_Homo sapiens_hsa05030	1.38856774
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.38356859
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32363789
27	Fatty acid elongation_Homo sapiens_hsa00062	1.31990241
28	Vibrio cholerae infection_Homo sapiens_hsa05110	1.26822368
29	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.26611783
30	Axon guidance_Homo sapiens_hsa04360	1.21232844
31	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.20833575
32	Insulin secretion_Homo sapiens_hsa04911	1.19559192
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.19352901
34	Spliceosome_Homo sapiens_hsa03040	1.16942751
35	Circadian entrainment_Homo sapiens_hsa04713	1.16871898
36	Propanoate metabolism_Homo sapiens_hsa00640	1.15554528
37	RNA degradation_Homo sapiens_hsa03018	1.15222624
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13633519
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.12313405
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12112154
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11631956
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05518993
43	Regulation of autophagy_Homo sapiens_hsa04140	1.03478721
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.01935971
45	RNA transport_Homo sapiens_hsa03013	0.98345163
46	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.96253410
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.96118557
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93047020
49	Phototransduction_Homo sapiens_hsa04744	0.93010815
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89681223
51	Cell cycle_Homo sapiens_hsa04110	0.88045955
52	Serotonergic synapse_Homo sapiens_hsa04726	0.86171346
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.83453758
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83098034
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78418147
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.73453596
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71891435
58	mTOR signaling pathway_Homo sapiens_hsa04150	0.71877660
59	RNA polymerase_Homo sapiens_hsa03020	0.71664566
60	AMPK signaling pathway_Homo sapiens_hsa04152	0.70229305
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.68580749
62	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.68394640
63	Base excision repair_Homo sapiens_hsa03410	0.67135147
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.63565470
65	Lysine degradation_Homo sapiens_hsa00310	0.62974890
66	Cholinergic synapse_Homo sapiens_hsa04725	0.62084576
67	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61391700
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60701609
69	Gap junction_Homo sapiens_hsa04540	0.60602834
70	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.59599575
71	Long-term depression_Homo sapiens_hsa04730	0.59024965
72	Glucagon signaling pathway_Homo sapiens_hsa04922	0.57540040
73	Carbon metabolism_Homo sapiens_hsa01200	0.57309771
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57208738
75	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.56954768
76	Melanogenesis_Homo sapiens_hsa04916	0.56629860
77	Long-term potentiation_Homo sapiens_hsa04720	0.55350592
78	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54656879
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.53977494
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.53790633
81	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52647686
82	Insulin signaling pathway_Homo sapiens_hsa04910	0.51574155
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.50911456
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.50457772
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49914707
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48582543
87	Olfactory transduction_Homo sapiens_hsa04740	0.47521890
88	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45545455
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45528407
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45128217
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44430727
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.44265880
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43471617
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42958281
95	ABC transporters_Homo sapiens_hsa02010	0.41957610
96	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.41638657
97	Tight junction_Homo sapiens_hsa04530	0.41379884
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40969428
99	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40765949
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40659415

SPIN3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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