SPINK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)7.61248507
2UDP-N-acetylglucosamine metabolic process (GO:0006047)7.42269479
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.41063852
4protein retention in ER lumen (GO:0006621)7.28545745
5prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.27231397
6valine metabolic process (GO:0006573)6.93906395
7COPI coating of Golgi vesicle (GO:0048205)6.77644734
8Golgi transport vesicle coating (GO:0048200)6.77644734
9negative regulation of epidermal cell differentiation (GO:0045605)6.68306083
10transcytosis (GO:0045056)6.38006967
11exocrine pancreas development (GO:0031017)6.18611769
12beta-amyloid metabolic process (GO:0050435)6.17826826
13regulation of phospholipase A2 activity (GO:0032429)6.07982455
14cysteine metabolic process (GO:0006534)5.96603664
15intestinal cholesterol absorption (GO:0030299)5.85965233
16angiotensin maturation (GO:0002003)5.84740534
17intestinal epithelial cell development (GO:0060576)5.72734711
18response to testosterone (GO:0033574)5.28080273
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.07708461
20ovulation cycle (GO:0042698)5.06131325
21branched-chain amino acid metabolic process (GO:0009081)5.05718218
22negative regulation of epidermis development (GO:0045683)5.01626741
23ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.87667084
24acute-phase response (GO:0006953)4.84982100
25positive regulation of nuclease activity (GO:0032075)4.83448170
26maintenance of gastrointestinal epithelium (GO:0030277)4.81660879
27digestion (GO:0007586)4.77385591
28branched-chain amino acid catabolic process (GO:0009083)4.76910288
29prostate gland epithelium morphogenesis (GO:0060740)4.74485842
30cellular modified amino acid catabolic process (GO:0042219)4.68897884
31epithelial cell maturation (GO:0002070)4.59296060
32sulfur amino acid catabolic process (GO:0000098)4.53712585
33mannose metabolic process (GO:0006013)4.53364694
34phosphatidylinositol acyl-chain remodeling (GO:0036149)4.49130300
35phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.46794416
36phosphatidylserine acyl-chain remodeling (GO:0036150)4.39213964
37COPII vesicle coating (GO:0048208)4.38173760
38regulation of nuclease activity (GO:0032069)4.37168619
39calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.34908307
40endoplasmic reticulum unfolded protein response (GO:0030968)4.31111754
41polyketide metabolic process (GO:0030638)4.29923709
42doxorubicin metabolic process (GO:0044598)4.29923709
43daunorubicin metabolic process (GO:0044597)4.29923709
44mitochondrial calcium ion transport (GO:0006851)4.29157413
45peptide catabolic process (GO:0043171)4.28067686
46positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.26923164
47xenobiotic catabolic process (GO:0042178)4.17612110
48cellular response to unfolded protein (GO:0034620)4.17001583
49digestive system process (GO:0022600)4.09200472
50growth hormone secretion (GO:0030252)4.07611569
51response to endoplasmic reticulum stress (GO:0034976)4.01423856
52ER-nucleus signaling pathway (GO:0006984)4.01073656
53fucose metabolic process (GO:0006004)3.99698197
54positive regulation of growth hormone secretion (GO:0060124)3.98260165
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.93871470
56tetrapyrrole metabolic process (GO:0033013)3.90668534
57regulation of keratinocyte proliferation (GO:0010837)3.90369385
58cellular glucuronidation (GO:0052695)3.89957586
59cellular response to topologically incorrect protein (GO:0035967)3.87484890
60regulation of keratinocyte differentiation (GO:0045616)3.83642706
61glucuronate metabolic process (GO:0019585)3.83391927
62uronic acid metabolic process (GO:0006063)3.83391927
63lysine catabolic process (GO:0006554)3.83222547
64lysine metabolic process (GO:0006553)3.83222547
65aminoglycoside antibiotic metabolic process (GO:0030647)3.80179130
66homocysteine metabolic process (GO:0050667)3.79668045
67regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.78694562
68antibacterial humoral response (GO:0019731)3.77488263
69regulation of clathrin-mediated endocytosis (GO:2000369)3.76662717
70zinc ion transport (GO:0006829)3.75863991
71creatine metabolic process (GO:0006600)3.74932607
72epithelial cell differentiation involved in prostate gland development (GO:0060742)3.74821696
73artery development (GO:0060840)3.72121071
74membrane lipid catabolic process (GO:0046466)3.70038567
75nucleotide-sugar metabolic process (GO:0009225)3.69426628
76regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.68653344
77endocrine hormone secretion (GO:0060986)3.68358311
78acute inflammatory response (GO:0002526)3.66772971
79arachidonic acid secretion (GO:0050482)3.65135875
80icosanoid secretion (GO:0032309)3.65135875
81aspartate family amino acid catabolic process (GO:0009068)3.64776097
82sulfate transmembrane transport (GO:1902358)3.62400060
83lung secretory cell differentiation (GO:0061140)3.56990179
84short-chain fatty acid metabolic process (GO:0046459)3.56876308
85intestinal absorption (GO:0050892)3.55953973
86L-phenylalanine metabolic process (GO:0006558)3.55508835
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55508835
88drug transmembrane transport (GO:0006855)3.53509177
89galactose catabolic process (GO:0019388)3.52773957
90protein N-linked glycosylation via asparagine (GO:0018279)3.52735085
91regulation of protein activation cascade (GO:2000257)3.50944444
92peptidyl-asparagine modification (GO:0018196)3.50667248
93negative regulation of protein activation cascade (GO:2000258)3.50086135
94antimicrobial humoral response (GO:0019730)3.48367252
95negative regulation of hormone metabolic process (GO:0032351)3.46804696
96proline metabolic process (GO:0006560)3.46137764
97cholesterol transport (GO:0030301)3.43964982
98sterol transport (GO:0015918)3.43964982
99proline biosynthetic process (GO:0006561)3.43156102
100vesicle coating (GO:0006901)3.40895432
101ceramide catabolic process (GO:0046514)3.40506260
102innate immune response in mucosa (GO:0002227)3.40478972
103regulation of cellular extravasation (GO:0002691)3.40281807
104glycolipid catabolic process (GO:0019377)3.35492105
105response to unfolded protein (GO:0006986)3.34556138
106icosanoid transport (GO:0071715)3.34210541
107fatty acid derivative transport (GO:1901571)3.34210541
108drug transport (GO:0015893)3.32322526
109regulation of cholesterol esterification (GO:0010872)3.32217496
110regulation of complement activation (GO:0030449)3.31395126
111mitochondrion distribution (GO:0048311)3.27830599
112epithelial structure maintenance (GO:0010669)3.25475982
113glycoside metabolic process (GO:0016137)3.25253693
114neutrophil mediated immunity (GO:0002446)3.24499369
115N-glycan processing (GO:0006491)3.24297385
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24225331
117L-phenylalanine catabolic process (GO:0006559)3.24225331
118glutathione derivative metabolic process (GO:1901685)3.24044702
119glutathione derivative biosynthetic process (GO:1901687)3.24044702
120peptidyl-proline hydroxylation (GO:0019511)3.23616846
121leukotriene biosynthetic process (GO:0019370)3.23280517
122protein N-linked glycosylation (GO:0006487)3.22981306
1234-hydroxyproline metabolic process (GO:0019471)3.21079350
124phosphatidylserine metabolic process (GO:0006658)3.20092600
125pyrimidine ribonucleoside catabolic process (GO:0046133)3.19656719
126N-acetylneuraminate metabolic process (GO:0006054)3.17949629
127complement activation, alternative pathway (GO:0006957)3.17616182
128fucose catabolic process (GO:0019317)3.17469518
129L-fucose metabolic process (GO:0042354)3.17469518
130L-fucose catabolic process (GO:0042355)3.17469518
131sulfur compound transport (GO:0072348)3.15887264
132response to topologically incorrect protein (GO:0035966)3.14709747
133regulation of metalloenzyme activity (GO:0048552)3.14211037
134cobalamin metabolic process (GO:0009235)3.14014143
135replicative senescence (GO:0090399)3.12861826
136regulation of pH (GO:0006885)3.10147004
137adult feeding behavior (GO:0008343)3.09567530
138anterior/posterior axis specification, embryo (GO:0008595)3.08947933
139regulation of triglyceride catabolic process (GO:0010896)3.08719594
1402-oxoglutarate metabolic process (GO:0006103)3.08711578
141nucleotide-sugar biosynthetic process (GO:0009226)3.08333735
142phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.07259976
143regulation of glucocorticoid secretion (GO:2000849)3.05019468
144GDP-mannose metabolic process (GO:0019673)3.04875837
145regulation of receptor binding (GO:1900120)3.04199598
146regulation of bile acid biosynthetic process (GO:0070857)3.03796073
147hormone catabolic process (GO:0042447)3.02752649
148transepithelial transport (GO:0070633)3.01131482
149cellular response to cadmium ion (GO:0071276)2.99723054
150L-serine transport (GO:0015825)2.98976907
151oxaloacetate metabolic process (GO:0006107)2.98747491
152water-soluble vitamin metabolic process (GO:0006767)2.97119600
153sphingolipid catabolic process (GO:0030149)2.93108997
154serine family amino acid metabolic process (GO:0009069)2.93038949
155peptide hormone processing (GO:0016486)2.92882426
156endocrine pancreas development (GO:0031018)2.91403845
157serine family amino acid biosynthetic process (GO:0009070)2.91215325
158intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.90846626
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.88280855
160regulation of cholesterol homeostasis (GO:2000188)2.88117631
161cellular response to zinc ion (GO:0071294)2.86803113
162negative regulation of interleukin-1 beta production (GO:0032691)2.85720854
163positive regulation of wound healing (GO:0090303)2.84383823
164signal peptide processing (GO:0006465)2.81115874
165protein targeting to Golgi (GO:0000042)2.81064871
166cellular amino acid catabolic process (GO:0009063)2.79713868
167mucosal immune response (GO:0002385)2.79436727
168positive regulation of steroid hormone secretion (GO:2000833)2.79397305
169phosphatidylcholine acyl-chain remodeling (GO:0036151)2.78586587
170positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.77029635
171progesterone metabolic process (GO:0042448)2.76997121
172phospholipid efflux (GO:0033700)2.74747824
173organ or tissue specific immune response (GO:0002251)2.69879868
174fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68703074
175reverse cholesterol transport (GO:0043691)2.66440414
176sphingomyelin metabolic process (GO:0006684)2.66255515
177alditol phosphate metabolic process (GO:0052646)2.66132487
178retinoid metabolic process (GO:0001523)2.65042713
179leukotriene metabolic process (GO:0006691)2.65041332
180phosphatidic acid biosynthetic process (GO:0006654)2.64461014
181phosphatidic acid metabolic process (GO:0046473)2.64461014
182bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59171554
183negative regulation of complement activation (GO:0045916)2.56095398
184phenylpropanoid metabolic process (GO:0009698)2.55339235
185high-density lipoprotein particle remodeling (GO:0034375)2.51407691
186vitamin metabolic process (GO:0006766)2.50838537
187phospholipid homeostasis (GO:0055091)2.50447579
188diterpenoid metabolic process (GO:0016101)2.50255472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62862787
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.50154087
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.47392190
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.06132771
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97995128
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97995128
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97995128
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90134032
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.89456364
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.87284720
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81704233
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.71448862
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.70629957
14* GATA4_25053715_ChIP-Seq_YYC3_Human2.68822612
15ZNF263_19887448_ChIP-Seq_K562_Human2.58154963
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.51766583
17* GATA6_25053715_ChIP-Seq_YYC3_Human2.44947363
18* SOX2_20726797_ChIP-Seq_SW620_Human2.41921482
19* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.38231036
20AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.25264391
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23562157
22CDX2_20551321_ChIP-Seq_CACO-2_Human2.15688464
23CLOCK_20551151_ChIP-Seq_293T_Human2.14808901
24RUNX1_27514584_Chip-Seq_MCF-7_Human2.06903024
25* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02531789
26FOXO3_23340844_ChIP-Seq_DLD1_Human2.01717095
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01145469
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98418693
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.82532845
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.81198948
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.78969996
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78447738
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77534619
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74801902
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74326740
36CHD1_26751641_Chip-Seq_LNCaP_Human1.72690825
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70989086
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70484668
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.70474295
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67110259
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65624624
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63602015
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63190486
44HTT_18923047_ChIP-ChIP_STHdh_Human1.62425355
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56919356
46GATA1_22025678_ChIP-Seq_K562_Human1.54826081
47* GATA3_24758297_ChIP-Seq_MCF-7_Human1.53208196
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52733913
49RACK7_27058665_Chip-Seq_MCF-7_Human1.49954329
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49113092
51AHR_22903824_ChIP-Seq_MCF-7_Human1.46797239
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.43213574
53CJUN_26792858_Chip-Seq_BT549_Human1.42396664
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42349571
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.41739552
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41088761
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.40827670
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39081263
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37060121
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36207421
61AR_21909140_ChIP-Seq_LNCAP_Human1.34775429
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29630295
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.25839013
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25017831
65ATF3_27146783_Chip-Seq_COLON_Human1.23762465
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22689844
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20721187
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19961975
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.17593458
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.17593458
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16201727
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12536737
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10850569
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10665172
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10304717
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08196816
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08121979
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05682731
79CDX2_22108803_ChIP-Seq_LS180_Human1.05128894
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04771519
81* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04209111
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04152894
83KLF5_25053715_ChIP-Seq_YYC3_Human1.04104393
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02974577
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02280727
86PHF8_20622853_ChIP-Seq_HELA_Human1.01399199
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01199529
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00163396
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.99985592
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99588073
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99548487
92TAF15_26573619_Chip-Seq_HEK293_Human0.99003169
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97156348
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97156348
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95760092
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95668297
97TP53_18474530_ChIP-ChIP_U2OS_Human0.95560020
98* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95063378
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95020857
100NFYA_21822215_ChIP-Seq_K562_Human0.94866529
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94553360
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93810608
103* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93471622
104TP63_23658742_ChIP-Seq_EP156T_Human0.93469683
105P300_19829295_ChIP-Seq_ESCs_Human0.93397133
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92951876
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92892462
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90536682
109CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90479384
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89018281
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.88785518
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.88557128
113ELF5_23300383_ChIP-Seq_T47D_Human0.88188261
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87690349
115AR_20517297_ChIP-Seq_VCAP_Human0.87046014
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87008757
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86489243
118GBX2_23144817_ChIP-Seq_PC3_Human0.85878118
119CBP_21632823_ChIP-Seq_H3396_Human0.85851016
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.85326810
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85251163
122ETV1_20927104_ChIP-Seq_GIST48_Human0.85158497
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84773453
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.84757272
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84685908
126GATA6_21074721_ChIP-Seq_CACO-2_Human0.84581812
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.84464647
128RBPJ_21746931_ChIP-Seq_IB4_Human0.84430044
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.84368902
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.83744260
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83744260
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83376873
133ZNF274_21170338_ChIP-Seq_K562_Hela0.82968828
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.82252361
135JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82052283
136P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81791103
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81603227
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81576947
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.80749542
140GATA2_19941826_ChIP-Seq_K562_Human0.79718011
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79601091
142AR_25329375_ChIP-Seq_VCAP_Human0.79447419
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78151992
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77881597
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.77410915
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76329620
147* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75204684
148* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75204684
149LXR_22292898_ChIP-Seq_THP-1_Human0.74889184
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74057055
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74025316
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73979735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.48811817
2MP0001666_abnormal_nutrient_absorption5.68888295
3MP0010386_abnormal_urinary_bladder4.46941136
4MP0005220_abnormal_exocrine_pancreas3.63651489
5MP0001873_stomach_inflammation3.58333582
6MP0009840_abnormal_foam_cell3.53830437
7MP0005365_abnormal_bile_salt3.46003832
8MP0005310_abnormal_salivary_gland3.16640622
9MP0002139_abnormal_hepatobiliary_system3.07600578
10MP0004264_abnormal_extraembryonic_tissu2.91710707
11MP0005083_abnormal_biliary_tract2.90947385
12MP0005360_urolithiasis2.83262807
13MP0001765_abnormal_ion_homeostasis2.76490175
14MP0009780_abnormal_chondrocyte_physiolo2.63713221
15MP0000537_abnormal_urethra_morphology2.44068517
16MP0004885_abnormal_endolymph2.38669891
17MP0009643_abnormal_urine_homeostasis2.37460024
18MP0004043_abnormal_pH_regulation2.36765054
19MP0008004_abnormal_stomach_pH2.18331726
20MP0004019_abnormal_vitamin_homeostasis2.17826074
21MP0005332_abnormal_amino_acid2.15026422
22MP0001756_abnormal_urination2.14559032
23MP0002166_altered_tumor_susceptibility2.09323498
24MP0005647_abnormal_sex_gland1.98079046
25MP0005085_abnormal_gallbladder_physiolo1.95152719
26MP0001664_abnormal_digestion1.92717848
27MP0003868_abnormal_feces_composition1.84384618
28MP0005636_abnormal_mineral_homeostasis1.82703319
29MP0005084_abnormal_gallbladder_morpholo1.79042506
30MP0000538_abnormal_urinary_bladder1.70999143
31MP0001485_abnormal_pinna_reflex1.69270591
32MP0005058_abnormal_lysosome_morphology1.69021038
33MP0002254_reproductive_system_inflammat1.63297691
34MP0000613_abnormal_salivary_gland1.62400420
35MP0003011_delayed_dark_adaptation1.57399822
36MP0004147_increased_porphyrin_level1.56825711
37MP0003705_abnormal_hypodermis_morpholog1.55359917
38MP0002009_preneoplasia1.50163439
39MP0003183_abnormal_peptide_metabolism1.45396984
40MP0002006_tumorigenesis1.36919857
41MP0003252_abnormal_bile_duct1.36410392
42MP0002136_abnormal_kidney_physiology1.34925041
43MP0002796_impaired_skin_barrier1.33340477
44MP0005448_abnormal_energy_balance1.31250041
45MP0010678_abnormal_skin_adnexa1.29482411
46MP0005381_digestive/alimentary_phenotyp1.21910926
47MP0000604_amyloidosis1.21236974
48MP0001663_abnormal_digestive_system1.20530588
49MP0005275_abnormal_skin_tensile1.20334044
50MP0003300_gastrointestinal_ulcer1.19430471
51MP0008872_abnormal_physiological_respon1.18916236
52MP0005319_abnormal_enzyme/_coenzyme1.18552001
53MP0004947_skin_inflammation1.18420539
54MP0000858_altered_metastatic_potential1.17161813
55MP0006072_abnormal_retinal_apoptosis1.14332360
56MP0003953_abnormal_hormone_level1.12214098
57MP0001501_abnormal_sleep_pattern1.11754197
58MP0003195_calcinosis1.08436940
59MP0001944_abnormal_pancreas_morphology1.08009803
60MP0000462_abnormal_digestive_system1.07860999
61MP0010329_abnormal_lipoprotein_level1.06856048
62MP0003959_abnormal_lean_body1.05169867
63MP0009384_cardiac_valve_regurgitation1.03805105
64MP0000470_abnormal_stomach_morphology1.02676527
65MP0003638_abnormal_response/metabolism_1.00322684
66MP0002876_abnormal_thyroid_physiology0.99980178
67MP0002693_abnormal_pancreas_physiology0.99099792
68MP0003866_abnormal_defecation0.98940615
69MP0002138_abnormal_hepatobiliary_system0.97301305
70MP0002098_abnormal_vibrissa_morphology0.97171449
71MP0010155_abnormal_intestine_physiology0.96931945
72MP0002909_abnormal_adrenal_gland0.95786495
73MP0008875_abnormal_xenobiotic_pharmacok0.93681017
74MP0005166_decreased_susceptibility_to0.92992007
75MP0002837_dystrophic_cardiac_calcinosis0.90911293
76MP0002118_abnormal_lipid_homeostasis0.89921147
77MP0002277_abnormal_respiratory_mucosa0.89370291
78MP0003315_abnormal_perineum_morphology0.88520928
79MP0005408_hypopigmentation0.88370838
80MP0000747_muscle_weakness0.88135553
81MP0000534_abnormal_ureter_morphology0.86722602
82MP0001919_abnormal_reproductive_system0.86287082
83MP0003879_abnormal_hair_cell0.81473550
84MP0004272_abnormal_basement_membrane0.81185972
85MP0002896_abnormal_bone_mineralization0.78370562
86MP0005452_abnormal_adipose_tissue0.77774083
87MP0006054_spinal_hemorrhage0.74968545
88MP0000230_abnormal_systemic_arterial0.70639661
89MP0008469_abnormal_protein_level0.69907723
90MP0003656_abnormal_erythrocyte_physiolo0.69404996
91MP0004270_analgesia0.69104355
92MP0005187_abnormal_penis_morphology0.68828654
93MP0000477_abnormal_intestine_morphology0.68403740
94MP0001764_abnormal_homeostasis0.66711567
95MP0005379_endocrine/exocrine_gland_phen0.66534618
96MP0003186_abnormal_redox_activity0.65686227
97MP0001845_abnormal_inflammatory_respons0.65363801
98MP0003724_increased_susceptibility_to0.65342168
99MP0000681_abnormal_thyroid_gland0.64433946
100MP0005451_abnormal_body_composition0.63164136
101MP0005645_abnormal_hypothalamus_physiol0.63156895
102MP0006082_CNS_inflammation0.61131186
103MP0002135_abnormal_kidney_morphology0.60477222
104MP0001299_abnormal_eye_distance/0.60413090
105MP0008961_abnormal_basal_metabolism0.60289978
106MP0004233_abnormal_muscle_weight0.60102103
107MP0004782_abnormal_surfactant_physiolog0.59868888
108MP0005367_renal/urinary_system_phenotyp0.59818517
109MP0000516_abnormal_urinary_system0.59818517
110MP0003045_fibrosis0.59765929
111MP0000609_abnormal_liver_physiology0.59701167
112MP0008438_abnormal_cutaneous_collagen0.58477159
113MP0003943_abnormal_hepatobiliary_system0.57051177
114MP0000371_diluted_coat_color0.56677457
115MP0003806_abnormal_nucleotide_metabolis0.56518580
116MP0002928_abnormal_bile_duct0.56249358
117MP0010352_gastrointestinal_tract_polyps0.56134019
118MP0000013_abnormal_adipose_tissue0.55978266
119MP0001346_abnormal_lacrimal_gland0.55622577
120MP0002089_abnormal_postnatal_growth/wei0.55160504
121MP0000377_abnormal_hair_follicle0.55035854
122MP0003283_abnormal_digestive_organ0.54618712
123MP0003329_amyloid_beta_deposits0.54300526
124MP0004130_abnormal_muscle_cell0.53514725
125MP0002078_abnormal_glucose_homeostasis0.53100924
126MP0005165_increased_susceptibility_to0.52695660
127MP0005334_abnormal_fat_pad0.52143295
128MP0004185_abnormal_adipocyte_glucose0.51214251
129MP0000598_abnormal_liver_morphology0.51159688
130MP0003646_muscle_fatigue0.50957664
131MP0000490_abnormal_crypts_of0.50164673
132MP0005023_abnormal_wound_healing0.49962654
133MP0002163_abnormal_gland_morphology0.49769733
134MP0004742_abnormal_vestibular_system0.49150011
135MP0009642_abnormal_blood_homeostasis0.48976212
136MP0002295_abnormal_pulmonary_circulatio0.45721527
137MP0009764_decreased_sensitivity_to0.43281227

Predicted human phenotypes

RankGene SetZ-score
1* Steatorrhea (HP:0002570)9.83413833
2Hypoproteinemia (HP:0003075)6.95679389
3* Exocrine pancreatic insufficiency (HP:0001738)6.11243867
4Hypoplasia of the uterus (HP:0000013)6.02261367
5Abnormality of cochlea (HP:0000375)5.92376332
6Aplasia involving bones of the upper limbs (HP:0009823)5.37587731
7Aplasia of the phalanges of the hand (HP:0009802)5.37587731
8Aplasia involving bones of the extremities (HP:0009825)5.37587731
9Abnormality of the phalanges of the 2nd finger (HP:0009541)4.70502172
10Fibular aplasia (HP:0002990)4.67714368
11Vacuolated lymphocytes (HP:0001922)4.43265108
12Abnormality of the proximal phalanges of the hand (HP:0009834)4.41241615
13* Pancreatitis (HP:0001733)4.26091608
14Vascular calcification (HP:0004934)4.20127396
15Abnormality of the 2nd finger (HP:0004100)4.19238955
16Aplasia/hypoplasia of the uterus (HP:0008684)4.00826622
17Morphological abnormality of the inner ear (HP:0011390)3.95338958
18Gout (HP:0001997)3.91366881
19Abnormality of the middle phalanges of the toes (HP:0010183)3.88802435
20Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.84775655
21Congenital sensorineural hearing impairment (HP:0008527)3.80896740
22Cardiovascular calcification (HP:0011915)3.76952429
23Hypobetalipoproteinemia (HP:0003563)3.72194581
24Abnormality of vitamin B metabolism (HP:0004340)3.62460921
25Spontaneous abortion (HP:0005268)3.60747685
26Hypoplastic nipples (HP:0002557)3.59081143
27Hyperglycinuria (HP:0003108)3.56725678
28Glycosuria (HP:0003076)3.42486711
29Abnormality of urine glucose concentration (HP:0011016)3.42486711
30Adactyly (HP:0009776)3.40582282
31Short hallux (HP:0010109)3.35427782
32Abnormality of vitamin metabolism (HP:0100508)3.29067437
33Late onset (HP:0003584)3.24423673
34Abnormality of chloride homeostasis (HP:0011422)3.18470525
35Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.17666848
36Goiter (HP:0000853)3.16404749
37Aplasia/Hypoplasia of the hallux (HP:0008362)3.14189696
38Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11457170
39Mucopolysacchariduria (HP:0008155)3.08657846
40Urinary glycosaminoglycan excretion (HP:0003541)3.08657846
41Thoracolumbar scoliosis (HP:0002944)3.08000397
42Abnormality of the common coagulation pathway (HP:0010990)3.02885792
43Complement deficiency (HP:0004431)3.00673024
442-3 toe syndactyly (HP:0004691)3.00578674
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95840496
46Abnormality of the vitamin B12 metabolism (HP:0004341)2.95124871
47Limb-girdle muscle atrophy (HP:0003797)2.94942254
48Abnormality of glycine metabolism (HP:0010895)2.93654184
49Abnormality of serine family amino acid metabolism (HP:0010894)2.93654184
50Long toe (HP:0010511)2.87329327
51Hypoglycemic coma (HP:0001325)2.84161763
52Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.83186205
53Protuberant abdomen (HP:0001538)2.83177611
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.79802902
55Hypomagnesemia (HP:0002917)2.79669668
56Rectal prolapse (HP:0002035)2.78323162
57Hypoplasia of the ulna (HP:0003022)2.76837006
58Popliteal pterygium (HP:0009756)2.76362903
59Glomerulonephritis (HP:0000099)2.76142356
60Xanthomatosis (HP:0000991)2.74936066
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73827538
62Abnormality of polysaccharide metabolism (HP:0011012)2.73827538
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73827538
64Dysostosis multiplex (HP:0000943)2.72600779
65Shawl scrotum (HP:0000049)2.69786289
66Ketoacidosis (HP:0001993)2.68883163
67Abnormality of the intrinsic pathway (HP:0010989)2.65754459
68Ketosis (HP:0001946)2.60440922
69Abnormal tarsal ossification (HP:0008369)2.60367012
70Abnormality of renal excretion (HP:0011036)2.55718922
71Hyperphosphatemia (HP:0002905)2.55017511
72Facial shape deformation (HP:0011334)2.52836884
73Potter facies (HP:0002009)2.52836884
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.50697029
75Increased CSF protein (HP:0002922)2.50253721
76Abnormal foot bone ossification (HP:0010675)2.48614040
77Abdominal distention (HP:0003270)2.48156736
78Hyperactive renin-angiotensin system (HP:0000841)2.47775831
79Malnutrition (HP:0004395)2.47470111
80Joint swelling (HP:0001386)2.46489924
81Hypoglycemic seizures (HP:0002173)2.46057656
82Mitral stenosis (HP:0001718)2.46042201
83Hyperinsulinemic hypoglycemia (HP:0000825)2.44803707
84Large for gestational age (HP:0001520)2.42886823
85Hypolipoproteinemia (HP:0010981)2.42645748
86Proximal tubulopathy (HP:0000114)2.40156406
87Hyperglycinemia (HP:0002154)2.37610608
88Hyperphosphaturia (HP:0003109)2.37386546
89Abnormality of magnesium homeostasis (HP:0004921)2.35739316
90Insulin-resistant diabetes mellitus (HP:0000831)2.35735109
91Tubulointerstitial nephritis (HP:0001970)2.34272238
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.33238301
93Arthropathy (HP:0003040)2.32628712
94Rimmed vacuoles (HP:0003805)2.32346421
95Aortic aneurysm (HP:0004942)2.31991988
96Thyroid carcinoma (HP:0002890)2.31327934
97Abnormal urine output (HP:0012590)2.30734189
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30444624
99Abnormality of the phalanges of the 5th finger (HP:0004213)2.25925751
100Disproportionate short-trunk short stature (HP:0003521)2.25814220
101Aplasia/Hypoplasia of the fibula (HP:0006492)2.24159620
102Ileus (HP:0002595)2.23841995
103Increased circulating renin level (HP:0000848)2.22997566
104Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.22964216
105Hyperparathyroidism (HP:0000843)2.21905603
106Abnormal cartilage morphology (HP:0002763)2.20579564
107Hypoplasia of the pons (HP:0012110)2.18359289
108Gingival bleeding (HP:0000225)2.16959052
109Increased purine levels (HP:0004368)2.16930929
110Hyperuricemia (HP:0002149)2.16930929
111Hyperglycemia (HP:0003074)2.16845606
112Hyperammonemia (HP:0001987)2.15300178
113Abnormality of purine metabolism (HP:0004352)2.15242617
114Retinal atrophy (HP:0001105)2.14640057
115Abnormality of complement system (HP:0005339)2.13764967
116Abnormality of secondary sexual hair (HP:0009888)2.11414123
117Abnormality of the axillary hair (HP:0100134)2.11414123
118Conjugated hyperbilirubinemia (HP:0002908)2.10471291
119Metabolic alkalosis (HP:0200114)2.09990628
120Abnormality of the nasal septum (HP:0000419)2.06067502
121Nausea (HP:0002018)2.05138721
122Beaking of vertebral bodies (HP:0004568)2.04953597
123Congenital, generalized hypertrichosis (HP:0004540)2.04564476
124Barrel-shaped chest (HP:0001552)2.02441400
125Systemic lupus erythematosus (HP:0002725)2.00456229
126Hypergonadotropic hypogonadism (HP:0000815)1.99114502
127Hypokalemic alkalosis (HP:0001949)1.97586300
128Distal arthrogryposis (HP:0005684)1.96675245
129Aplasia/Hypoplasia of the ulna (HP:0006495)1.96334526
130* Fat malabsorption (HP:0002630)1.95799532
131Short femoral neck (HP:0100864)1.93995736
132Abnormality of the pons (HP:0007361)1.92117072
133Abnormal urine phosphate concentration (HP:0012599)1.91919357
134Hepatocellular carcinoma (HP:0001402)1.89594114
135Dehydration (HP:0001944)1.89044906
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86152995
137Synostosis of carpal bones (HP:0005048)1.85380916
138Abnormality of the epiphyses of the hand (HP:0005924)1.85287089
139Nephritis (HP:0000123)1.82970582
140Double outlet right ventricle (HP:0001719)1.82839922
141Congenital malformation of the right heart (HP:0011723)1.82839922
142Abnormality of small intestinal villus morphology (HP:0011472)1.82663454
143Villous atrophy (HP:0011473)1.82663454
144Abnormality of the renal cortex (HP:0011035)1.82315804
145Hydroxyprolinuria (HP:0003080)1.81376848
146Abnormality of proline metabolism (HP:0010907)1.81376848
147Polyuria (HP:0000103)1.81115034
148Cervical subluxation (HP:0003308)1.78932824
149Methylmalonic acidemia (HP:0002912)1.77972682
150Intrahepatic cholestasis (HP:0001406)1.77959634
151Tubulointerstitial fibrosis (HP:0005576)1.77874851
152Right ventricular cardiomyopathy (HP:0011663)1.76772444
153Abnormality of macrophages (HP:0004311)1.74821697
154Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.74597231
155Insulin resistance (HP:0000855)1.73556079
156Decreased circulating renin level (HP:0003351)1.73292390
157Abnormality of fatty-acid metabolism (HP:0004359)1.72684860
158Prolonged partial thromboplastin time (HP:0003645)1.71927548
159Generalized aminoaciduria (HP:0002909)1.71508506
160Hypoplasia of the odontoid process (HP:0003311)1.71481374
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71417892
162Lymphangioma (HP:0100764)1.70988750
163Renal tubular dysfunction (HP:0000124)1.70886618
164Abnormal pancreas size (HP:0012094)1.70638522
165Submucous cleft hard palate (HP:0000176)1.69764759
166Symptomatic seizures (HP:0011145)1.69757487
167Abnormal biliary tract morphology (HP:0012440)1.69641616
168Broad hallux (HP:0010055)1.69505181
169Osteomalacia (HP:0002749)1.68553366
170Sex reversal (HP:0012245)1.67475335
171Abnormal sex determination (HP:0012244)1.67475335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.16931042
2AKT35.77557303
3ERN14.68226603
4OXSR14.60380675
5BCKDK4.51770414
6STK244.32682120
7MAP3K123.95425881
8TAOK33.78084176
9MST43.67054786
10LMTK22.97478830
11LATS12.89563661
12ACVR1B2.81938943
13FRK2.77089529
14GRK12.47004315
15WNK42.30088873
16EPHA32.26504629
17PIK3CG2.15581677
18SCYL21.99078845
19EEF2K1.94893437
20BMPR1B1.85574020
21FGFR41.75420913
22PRKG21.73694636
23SIK11.70644550
24FGFR31.69497436
25BMPR21.59385631
26MAPKAPK31.59263777
27MAP3K21.54407717
28NLK1.53850745
29MYLK1.50299014
30CASK1.46583077
31TRIB31.43303024
32MAP3K61.38061249
33PDK21.37549812
34LRRK21.31072131
35ERBB31.29310296
36PTK61.22781945
37MAP2K21.22134627
38DAPK21.20907121
39TNK21.20774359
40FER1.18436447
41PIK3CA1.14081826
42MAP3K91.13662241
43EIF2AK31.08772748
44INSRR1.07913445
45PKN21.07126174
46RPS6KB20.98414117
47ZAP700.94594661
48TTN0.93346833
49IRAK10.91834736
50ADRBK20.91638187
51PAK20.89414600
52WNK30.88634039
53PAK30.87989439
54STK100.84554167
55PRKCE0.80868715
56TGFBR20.79671569
57STK38L0.79337850
58TESK10.74509587
59NTRK30.74440433
60PRKCI0.72609230
61NUAK10.72081304
62PHKG20.71111821
63PHKG10.71111821
64FGFR20.67916655
65STK160.67689860
66TESK20.65996146
67DAPK10.64586625
68NME10.64323060
69MST1R0.64196652
70DAPK30.56575815
71EPHA20.54478152
72PDK30.54237368
73PDK40.54237368
74MAP3K70.54107777
75DMPK0.53886693
76MET0.52655430
77WNK10.51906529
78STK30.50793618
79CAMKK10.50682440
80MELK0.46998974
81MAP3K50.45850994
82ILK0.45664663
83PDGFRA0.44564204
84MAP3K30.43726037
85MTOR0.42789287
86ADRBK10.40368081
87STK380.40110070
88PASK0.40074099
89PRKAA20.39564559
90PRKACG0.39396104
91PTK20.38916726
92JAK20.38428222
93RIPK10.36479912
94BRSK20.36438791
95CSNK1A10.35435022
96MAP2K10.35171048
97TRPM70.34504659
98MAP3K80.34463132
99RET0.34408217
100PRKCA0.34333236
101MAP2K70.33923868
102DDR20.32551165
103NEK60.32449317
104LATS20.31944575
105FGFR10.31001866
106FLT30.30368360
107CDK80.30231177
108MAP4K20.30013135
109KSR20.28185836
110MAP3K10.27672406
111CDK190.27600588
112ROCK10.27124752
113PDPK10.26748383
114PAK40.26643067
115MAPK70.26614109
116ROCK20.26134514
117PRKAA10.25581482
118PDGFRB0.23643642
119IRAK30.23349375
120RPS6KA20.23059009
121ERBB20.20944060
122RPS6KB10.20930068
123EPHB10.20885321
124PDK10.20695278
125JAK10.20659553
126CDC42BPA0.20296996
127TAOK10.17390762
128PRKD10.15442088
129BMX0.15426382
130TYK20.14249508
131PRKCQ0.14124587
132EGFR0.12798862
133CSF1R0.12232142
134MAP3K40.11535299
135ICK0.11121508
136NTRK10.11076586
137MAP2K60.10884067
138GSK3A0.10647872
139JAK30.10161575
140SGK30.09912958
141PRKACB0.09318504
142PRKCZ0.09001346
143RPS6KA10.08351236
144MAP2K40.07605354
145FYN0.07326758
146AKT20.06807119

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.23213130
2Sulfur metabolism_Homo sapiens_hsa009203.77720636
3Pancreatic secretion_Homo sapiens_hsa049723.40186515
4Renin-angiotensin system_Homo sapiens_hsa046143.36496778
5Protein digestion and absorption_Homo sapiens_hsa049743.24481056
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.94629499
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76876136
8Protein export_Homo sapiens_hsa030602.76187176
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.68014804
10Fat digestion and absorption_Homo sapiens_hsa049752.61449861
11Propanoate metabolism_Homo sapiens_hsa006402.42186804
12Linoleic acid metabolism_Homo sapiens_hsa005912.07378410
13Other glycan degradation_Homo sapiens_hsa005112.00411526
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.83590141
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80478766
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78854091
17Complement and coagulation cascades_Homo sapiens_hsa046101.78664306
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78439954
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69558924
20Mineral absorption_Homo sapiens_hsa049781.68886141
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68103746
22Chemical carcinogenesis_Homo sapiens_hsa052041.64772864
23Fatty acid degradation_Homo sapiens_hsa000711.64359407
24Arginine and proline metabolism_Homo sapiens_hsa003301.57232745
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54441442
26Glycerolipid metabolism_Homo sapiens_hsa005611.52183506
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.50926078
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50877982
29N-Glycan biosynthesis_Homo sapiens_hsa005101.48363458
30Vibrio cholerae infection_Homo sapiens_hsa051101.48353202
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46232025
32Vitamin digestion and absorption_Homo sapiens_hsa049771.45926438
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45814127
34Nitrogen metabolism_Homo sapiens_hsa009101.43068157
35Ether lipid metabolism_Homo sapiens_hsa005651.33125210
36Retinol metabolism_Homo sapiens_hsa008301.32831582
37Folate biosynthesis_Homo sapiens_hsa007901.32276594
38Arachidonic acid metabolism_Homo sapiens_hsa005901.32097397
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32083040
40Thyroid hormone synthesis_Homo sapiens_hsa049181.29551924
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19856761
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19392451
43beta-Alanine metabolism_Homo sapiens_hsa004101.18721222
44Pyruvate metabolism_Homo sapiens_hsa006201.17396751
45Selenocompound metabolism_Homo sapiens_hsa004501.15461054
46Fructose and mannose metabolism_Homo sapiens_hsa000511.11976924
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11524688
48Arginine biosynthesis_Homo sapiens_hsa002201.07290779
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01185014
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00542266
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00296217
52Tryptophan metabolism_Homo sapiens_hsa003800.96623175
53Lysosome_Homo sapiens_hsa041420.93841612
54Starch and sucrose metabolism_Homo sapiens_hsa005000.91039313
55Butanoate metabolism_Homo sapiens_hsa006500.90122174
56Biosynthesis of amino acids_Homo sapiens_hsa012300.87490427
57Bile secretion_Homo sapiens_hsa049760.85400404
58Peroxisome_Homo sapiens_hsa041460.76832880
59Caffeine metabolism_Homo sapiens_hsa002320.76631796
60Fatty acid metabolism_Homo sapiens_hsa012120.76221930
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75561306
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73920170
63Vitamin B6 metabolism_Homo sapiens_hsa007500.71734441
64Carbon metabolism_Homo sapiens_hsa012000.71009234
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70448875
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.70024705
67Glutathione metabolism_Homo sapiens_hsa004800.69077340
68Tight junction_Homo sapiens_hsa045300.68242682
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66847698
70Lysine degradation_Homo sapiens_hsa003100.66508074
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63289813
72Salivary secretion_Homo sapiens_hsa049700.60639001
73Prostate cancer_Homo sapiens_hsa052150.57948713
74Tyrosine metabolism_Homo sapiens_hsa003500.56244113
75Histidine metabolism_Homo sapiens_hsa003400.54979894
76PPAR signaling pathway_Homo sapiens_hsa033200.53029753
77Collecting duct acid secretion_Homo sapiens_hsa049660.52554537
78Insulin resistance_Homo sapiens_hsa049310.52436233
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.51855216
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51710316
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51326483
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50938499
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49742141
84Inositol phosphate metabolism_Homo sapiens_hsa005620.48716906
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46693572
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.46554065
87Endometrial cancer_Homo sapiens_hsa052130.45719651
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43108128
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40707933
90Hippo signaling pathway_Homo sapiens_hsa043900.38512297
91Gastric acid secretion_Homo sapiens_hsa049710.38374097
92Metabolic pathways_Homo sapiens_hsa011000.37168284
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36482209
94mTOR signaling pathway_Homo sapiens_hsa041500.36325543
95Staphylococcus aureus infection_Homo sapiens_hsa051500.32780899
96Bladder cancer_Homo sapiens_hsa052190.30570878
97Adherens junction_Homo sapiens_hsa045200.30271371
98Hepatitis C_Homo sapiens_hsa051600.28778207
99Sphingolipid metabolism_Homo sapiens_hsa006000.28623602
100Thyroid cancer_Homo sapiens_hsa052160.27181831
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.23152153
102ABC transporters_Homo sapiens_hsa020100.23018283
103Oxidative phosphorylation_Homo sapiens_hsa001900.22695875
104Ovarian steroidogenesis_Homo sapiens_hsa049130.21509905
105Phenylalanine metabolism_Homo sapiens_hsa003600.21272738
106AMPK signaling pathway_Homo sapiens_hsa041520.21254286
107TGF-beta signaling pathway_Homo sapiens_hsa043500.20951593
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19941542
109Fatty acid elongation_Homo sapiens_hsa000620.19105057
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18824608
111Circadian rhythm_Homo sapiens_hsa047100.18259216
112Insulin secretion_Homo sapiens_hsa049110.16826558
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.16582842
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16472752
115Galactose metabolism_Homo sapiens_hsa000520.14691369
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.14349215
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14252933
118Amoebiasis_Homo sapiens_hsa051460.12797506
119Influenza A_Homo sapiens_hsa051640.12693138
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.11842214
121Focal adhesion_Homo sapiens_hsa045100.11419147
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11342047
123Choline metabolism in cancer_Homo sapiens_hsa052310.10617773
124Steroid biosynthesis_Homo sapiens_hsa001000.10614389
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.10458645
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09923982
127Pertussis_Homo sapiens_hsa051330.09797341
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08021521
129Type II diabetes mellitus_Homo sapiens_hsa049300.06918160

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