ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.87255566
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.95888651
3	neuronal action potential (GO:0019228)	3.60920749
4	behavioral response to ethanol (GO:0048149)	3.48796953
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.47811153
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.47019806
7	protein polyglutamylation (GO:0018095)	3.46593483
8	nonmotile primary cilium assembly (GO:0035058)	3.45032915
9	kynurenine metabolic process (GO:0070189)	3.39062844
10	epithelial cilium movement (GO:0003351)	3.37092616
11	regulation of action potential (GO:0098900)	3.36377543
12	indole-containing compound catabolic process (GO:0042436)	3.33877787
13	indolalkylamine catabolic process (GO:0046218)	3.33877787
14	tryptophan catabolic process (GO:0006569)	3.33877787
15	primary amino compound metabolic process (GO:1901160)	3.32965192
16	positive regulation of action potential (GO:0045760)	3.32035667
17	serotonin metabolic process (GO:0042428)	3.30901097
18	fucose catabolic process (GO:0019317)	3.30349481
19	L-fucose metabolic process (GO:0042354)	3.30349481
20	L-fucose catabolic process (GO:0042355)	3.30349481
21	transmission of nerve impulse (GO:0019226)	3.28959413
22	indolalkylamine metabolic process (GO:0006586)	3.22373179
23	somite development (GO:0061053)	3.20883053
24	piRNA metabolic process (GO:0034587)	3.06038702
25	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.02266152
26	reflex (GO:0060004)	3.01393992
27	response to pheromone (GO:0019236)	3.00222320
28	gamma-aminobutyric acid transport (GO:0015812)	2.99962889
29	indole-containing compound metabolic process (GO:0042430)	2.95179896
30	neural tube formation (GO:0001841)	2.93215518
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92880414
32	NADH dehydrogenase complex assembly (GO:0010257)	2.92880414
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92880414
34	cellular biogenic amine catabolic process (GO:0042402)	2.92727616
35	amine catabolic process (GO:0009310)	2.92727616
36	nucleobase catabolic process (GO:0046113)	2.91209358
37	cilium movement (GO:0003341)	2.90321320
38	cilium or flagellum-dependent cell motility (GO:0001539)	2.89615258
39	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.85593079
40	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.85079557
41	detection of light stimulus involved in sensory perception (GO:0050962)	2.83083063
42	detection of light stimulus involved in visual perception (GO:0050908)	2.83083063
43	negative regulation of sodium ion transport (GO:0010766)	2.82304263
44	sulfation (GO:0051923)	2.80662113
45	tryptophan metabolic process (GO:0006568)	2.80275154
46	membrane depolarization during action potential (GO:0086010)	2.78803739
47	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.78097009
48	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.78097009
49	cilium organization (GO:0044782)	2.78031133
50	protein complex biogenesis (GO:0070271)	2.76957759
51	cilium morphogenesis (GO:0060271)	2.76786019
52	axoneme assembly (GO:0035082)	2.75149409
53	nephron epithelium morphogenesis (GO:0072088)	2.74756863
54	nephron tubule morphogenesis (GO:0072078)	2.74756863
55	regulation of neurotransmitter uptake (GO:0051580)	2.73343766
56	cilium assembly (GO:0042384)	2.71167409
57	postsynaptic membrane organization (GO:0001941)	2.69707141
58	cardiovascular system development (GO:0072358)	2.68407935
59	synaptic transmission, cholinergic (GO:0007271)	2.65288505
60	regulation of gene silencing by miRNA (GO:0060964)	2.64979617
61	regulation of gene silencing by RNA (GO:0060966)	2.64979617
62	regulation of posttranscriptional gene silencing (GO:0060147)	2.64979617
63	cellular ketone body metabolic process (GO:0046950)	2.63597498
64	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.63436313
65	head development (GO:0060322)	2.62836405
66	retinal cone cell development (GO:0046549)	2.62815472
67	protein localization to synapse (GO:0035418)	2.62421066
68	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.61896485
69	negative regulation of systemic arterial blood pressure (GO:0003085)	2.60435187
70	protein localization to cilium (GO:0061512)	2.59872158
71	auditory behavior (GO:0031223)	2.59729581
72	negative regulation of telomere maintenance (GO:0032205)	2.59464763
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58689170
74	negative regulation of mast cell activation (GO:0033004)	2.58056939
75	peristalsis (GO:0030432)	2.57336320
76	regulation of cilium movement (GO:0003352)	2.57131306
77	parturition (GO:0007567)	2.56514935
78	positive regulation of gastrulation (GO:2000543)	2.55580412
79	action potential (GO:0001508)	2.55216350
80	cell proliferation in forebrain (GO:0021846)	2.54228536
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52980884
82	ubiquinone biosynthetic process (GO:0006744)	2.52106475
83	photoreceptor cell maintenance (GO:0045494)	2.50039102
84	neuron cell-cell adhesion (GO:0007158)	2.49914335
85	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.48969797
86	dendritic spine morphogenesis (GO:0060997)	2.48235948
87	snRNA transcription (GO:0009301)	2.46889963
88	replication fork processing (GO:0031297)	2.46321052
89	endoderm formation (GO:0001706)	2.46236369
90	intraciliary transport (GO:0042073)	2.45935285
91	retinal ganglion cell axon guidance (GO:0031290)	2.45339816
92	kidney morphogenesis (GO:0060993)	2.44222390
93	rhodopsin mediated signaling pathway (GO:0016056)	2.43499159
94	central nervous system myelination (GO:0022010)	2.43022794
95	axon ensheathment in central nervous system (GO:0032291)	2.43022794
96	ubiquinone metabolic process (GO:0006743)	2.42814172
97	water-soluble vitamin biosynthetic process (GO:0042364)	2.41717535
98	spinal cord motor neuron differentiation (GO:0021522)	2.40117902
99	DNA methylation involved in gamete generation (GO:0043046)	2.39780860
100	photoreceptor cell development (GO:0042461)	2.39241510

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.39423264
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54828517
3	VDR_22108803_ChIP-Seq_LS180_Human	3.23297264
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02815534
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.63095135
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56058889
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52444733
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46465412
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23668905
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15719174
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09668851
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.07576355
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96574499
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93536440
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92270018
16	P300_19829295_ChIP-Seq_ESCs_Human	1.90997655
17	FUS_26573619_Chip-Seq_HEK293_Human	1.85323302
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.83140453
19	EWS_26573619_Chip-Seq_HEK293_Human	1.82835701
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.82061640
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79826211
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78531707
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.73525295
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71088095
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64610020
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61161575
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.61040495
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.60638430
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57331474
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56533483
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54168763
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54032264
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53958463
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53958463
35	* STAT3_23295773_ChIP-Seq_U87_Human	1.51553918
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51353034
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50010258
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.49706712
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48957461
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48591239
41	AR_25329375_ChIP-Seq_VCAP_Human	1.46415876
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46255140
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44239527
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43814354
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43523975
46	TCF4_23295773_ChIP-Seq_U87_Human	1.43324257
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43066504
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42968523
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39149799
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38800634
51	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.36560115
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35442976
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33805187
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32483595
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.32483595
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.32474713
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30316371
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30170210
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28919343
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27893954
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.26875093
62	DROSHA_22980978_ChIP-Seq_HELA_Human	1.26505774
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25944923
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25570003
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24770046
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23316599
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21867125
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20854898
69	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.19337220
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.18976326
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15352371
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13959447
73	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13820967
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.13248075
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12260879
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12260879
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11163106
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11163106
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10357560
80	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09909722
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09903312
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08244050
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08059633
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06795171
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05340187
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04146658
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03870298
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03267900
89	TP53_16413492_ChIP-PET_HCT116_Human	1.03206983
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02750722
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02645431
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.00688612
93	* NCOR_22424771_ChIP-Seq_293T_Human	1.00097258
94	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99988903
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98183639
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98047572
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96695863
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96658327
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96237834
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96182070

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.33153576
2	MP0008877_abnormal_DNA_methylation	3.11530443
3	MP0000569_abnormal_digit_pigmentation	2.76976819
4	MP0006292_abnormal_olfactory_placode	2.72875053
5	MP0009046_muscle_twitch	2.53680895
6	MP0003136_yellow_coat_color	2.23867805
7	MP0003880_abnormal_central_pattern	2.20169556
8	MP0002653_abnormal_ependyma_morphology	2.18599715
9	MP0001968_abnormal_touch/_nociception	2.17341881
10	MP0005551_abnormal_eye_electrophysiolog	2.15770326
11	MP0003195_calcinosis	2.12088617
12	MP0004133_heterotaxia	2.01847472
13	MP0006276_abnormal_autonomic_nervous	1.97451183
14	MP0004142_abnormal_muscle_tone	1.96186245
15	MP0009745_abnormal_behavioral_response	1.94740485
16	MP0001485_abnormal_pinna_reflex	1.91233513
17	MP0002272_abnormal_nervous_system	1.85174633
18	MP0004885_abnormal_endolymph	1.83886549
19	MP0001486_abnormal_startle_reflex	1.77535093
20	MP0002638_abnormal_pupillary_reflex	1.77462802
21	MP0002736_abnormal_nociception_after	1.76853002
22	MP0002735_abnormal_chemical_nociception	1.69669921
23	MP0000778_abnormal_nervous_system	1.66490847
24	MP0006072_abnormal_retinal_apoptosis	1.65219382
25	MP0003890_abnormal_embryonic-extraembry	1.65192652
26	MP0002102_abnormal_ear_morphology	1.64808939
27	MP0005646_abnormal_pituitary_gland	1.64702779
28	MP0003121_genomic_imprinting	1.64054609
29	MP0003646_muscle_fatigue	1.60032153
30	MP0000427_abnormal_hair_cycle	1.58013283
31	MP0002064_seizures	1.53566912
32	MP0003878_abnormal_ear_physiology	1.53337235
33	MP0005377_hearing/vestibular/ear_phenot	1.53337235
34	MP0002837_dystrophic_cardiac_calcinosis	1.52454199
35	MP0004742_abnormal_vestibular_system	1.51939242
36	MP0008872_abnormal_physiological_respon	1.51068919
37	MP0002572_abnormal_emotion/affect_behav	1.49720881
38	MP0001986_abnormal_taste_sensitivity	1.49070270
39	MP0005423_abnormal_somatic_nervous	1.45839334
40	MP0003635_abnormal_synaptic_transmissio	1.45630592
41	MP0000631_abnormal_neuroendocrine_gland	1.44796534
42	MP0002067_abnormal_sensory_capabilities	1.44198780
43	MP0009379_abnormal_foot_pigmentation	1.43999619
44	MP0002557_abnormal_social/conspecific_i	1.43505942
45	MP0003122_maternal_imprinting	1.43360244
46	MP0002733_abnormal_thermal_nociception	1.43032601
47	MP0002160_abnormal_reproductive_system	1.41114312
48	MP0004043_abnormal_pH_regulation	1.40449843
49	MP0005645_abnormal_hypothalamus_physiol	1.38378223
50	MP0001970_abnormal_pain_threshold	1.36491026
51	MP0002734_abnormal_mechanical_nocicepti	1.33952991
52	MP0002938_white_spotting	1.33762946
53	MP0005253_abnormal_eye_physiology	1.33626749
54	MP0002876_abnormal_thyroid_physiology	1.32033701
55	MP0004145_abnormal_muscle_electrophysio	1.31999169
56	MP0002063_abnormal_learning/memory/cond	1.31765447
57	MP0003011_delayed_dark_adaptation	1.31720293
58	MP0002928_abnormal_bile_duct	1.27325958
59	MP0003283_abnormal_digestive_organ	1.25490000
60	MP0005195_abnormal_posterior_eye	1.20833116
61	MP0002184_abnormal_innervation	1.19711261
62	MP0005174_abnormal_tail_pigmentation	1.18679818
63	MP0008875_abnormal_xenobiotic_pharmacok	1.18426867
64	MP0002163_abnormal_gland_morphology	1.17137299
65	MP0001440_abnormal_grooming_behavior	1.16294126
66	MP0002752_abnormal_somatic_nervous	1.15810461
67	MP0001905_abnormal_dopamine_level	1.15446004
68	MP0000026_abnormal_inner_ear	1.15384246
69	MP0005389_reproductive_system_phenotype	1.15050072
70	MP0004147_increased_porphyrin_level	1.15032056
71	MP0008789_abnormal_olfactory_epithelium	1.13622618
72	MP0000955_abnormal_spinal_cord	1.12681128
73	MP0001984_abnormal_olfaction	1.11886919
74	MP0004924_abnormal_behavior	1.08541160
75	MP0005386_behavior/neurological_phenoty	1.08541160
76	MP0002882_abnormal_neuron_morphology	1.05660067
77	MP0003119_abnormal_digestive_system	1.02546958
78	MP0001293_anophthalmia	1.01506812
79	MP0001501_abnormal_sleep_pattern	1.01449848
80	MP0001919_abnormal_reproductive_system	1.00369057
81	MP0010386_abnormal_urinary_bladder	0.99739667
82	MP0002095_abnormal_skin_pigmentation	0.99419159
83	MP0001529_abnormal_vocalization	0.98261343
84	MP0000049_abnormal_middle_ear	0.96551899
85	MP0002234_abnormal_pharynx_morphology	0.94753488
86	MP0005084_abnormal_gallbladder_morpholo	0.94188796
87	MP0000372_irregular_coat_pigmentation	0.93344685
88	MP0001963_abnormal_hearing_physiology	0.92830415
89	MP0001324_abnormal_eye_pigmentation	0.92372870
90	MP0002909_abnormal_adrenal_gland	0.88783823
91	MP0005187_abnormal_penis_morphology	0.87892859
92	MP0002229_neurodegeneration	0.87547385
93	MP0004859_abnormal_synaptic_plasticity	0.86629972
94	MP0000230_abnormal_systemic_arterial	0.86291155
95	MP0005394_taste/olfaction_phenotype	0.86071806
96	MP0005499_abnormal_olfactory_system	0.86071806
97	MP0003698_abnormal_male_reproductive	0.84591494
98	MP0004130_abnormal_muscle_cell	0.83143117
99	MP0001188_hyperpigmentation	0.82902449
100	MP0003123_paternal_imprinting	0.81996419

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.62978497
2	Pancreatic fibrosis (HP:0100732)	4.58941510
3	Abnormality of midbrain morphology (HP:0002418)	4.50857394
4	Molar tooth sign on MRI (HP:0002419)	4.50857394
5	True hermaphroditism (HP:0010459)	4.18734640
6	Nephronophthisis (HP:0000090)	3.82502703
7	Congenital stationary night blindness (HP:0007642)	3.60292745
8	Medial flaring of the eyebrow (HP:0010747)	3.59990402
9	Hyperventilation (HP:0002883)	3.53069129
10	Abnormality of the renal medulla (HP:0100957)	3.31296840
11	Gait imbalance (HP:0002141)	3.28013604
12	Cystic liver disease (HP:0006706)	3.17591590
13	Type II lissencephaly (HP:0007260)	3.08305767
14	Congenital primary aphakia (HP:0007707)	3.06201640
15	Chronic hepatic failure (HP:0100626)	2.93669158
16	Nephrogenic diabetes insipidus (HP:0009806)	2.87518813
17	Progressive cerebellar ataxia (HP:0002073)	2.86250138
18	Genetic anticipation (HP:0003743)	2.84266698
19	Abnormality of the renal cortex (HP:0011035)	2.80257564
20	Tubular atrophy (HP:0000092)	2.76511174
21	Sclerocornea (HP:0000647)	2.75442886
22	Protruding tongue (HP:0010808)	2.68032870
23	Inability to walk (HP:0002540)	2.51913054
24	Genital tract atresia (HP:0001827)	2.51811218
25	Vaginal atresia (HP:0000148)	2.47904187
26	Anencephaly (HP:0002323)	2.47703022
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.43895036
28	Broad-based gait (HP:0002136)	2.42635058
29	Abnormality of alanine metabolism (HP:0010916)	2.42629918
30	Hyperalaninemia (HP:0003348)	2.42629918
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42629918
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42250753
33	Congenital, generalized hypertrichosis (HP:0004540)	2.41216317
34	Lissencephaly (HP:0001339)	2.40842931
35	Congenital hepatic fibrosis (HP:0002612)	2.38815858
36	Poor coordination (HP:0002370)	2.36898927
37	Abnormal drinking behavior (HP:0030082)	2.36176137
38	Polydipsia (HP:0001959)	2.36176137
39	Abolished electroretinogram (ERG) (HP:0000550)	2.32695916
40	Furrowed tongue (HP:0000221)	2.31565100
41	Cerebellar dysplasia (HP:0007033)	2.30570671
42	Male pseudohermaphroditism (HP:0000037)	2.28814647
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.28374346
44	Absent/shortened dynein arms (HP:0200106)	2.28374346
45	Attenuation of retinal blood vessels (HP:0007843)	2.24051954
46	Rib fusion (HP:0000902)	2.23126487
47	Gaze-evoked nystagmus (HP:0000640)	2.22649479
48	Patellar aplasia (HP:0006443)	2.22175796
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.20732144
50	Large for gestational age (HP:0001520)	2.19391332
51	Pendular nystagmus (HP:0012043)	2.14111352
52	Postaxial foot polydactyly (HP:0001830)	2.11851351
53	Aplasia/Hypoplasia of the patella (HP:0006498)	2.11684551
54	Birth length less than 3rd percentile (HP:0003561)	2.06655644
55	Clumsiness (HP:0002312)	2.05039370
56	Optic nerve hypoplasia (HP:0000609)	2.02454457
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.00529558
58	Drooling (HP:0002307)	1.98693338
59	Febrile seizures (HP:0002373)	1.96251767
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.94257484
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94257484
62	Hypoplastic ischia (HP:0003175)	1.94207464
63	Polyuria (HP:0000103)	1.93202746
64	Keratoconus (HP:0000563)	1.92091847
65	Increased corneal curvature (HP:0100692)	1.92091847
66	Concave nail (HP:0001598)	1.92015766
67	Pachygyria (HP:0001302)	1.91842131
68	Abnormal ciliary motility (HP:0012262)	1.91727680
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89987559
70	Anophthalmia (HP:0000528)	1.88926753
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87769019
72	Preaxial hand polydactyly (HP:0001177)	1.86098270
73	Oligodactyly (hands) (HP:0001180)	1.85041279
74	Decreased circulating renin level (HP:0003351)	1.83940365
75	Postaxial hand polydactyly (HP:0001162)	1.83589997
76	Absent speech (HP:0001344)	1.83409605
77	Agitation (HP:0000713)	1.83300042
78	Left ventricular hypertrophy (HP:0001712)	1.81763941
79	Abnormal pancreas size (HP:0012094)	1.81138516
80	Aganglionic megacolon (HP:0002251)	1.80896947
81	Tachypnea (HP:0002789)	1.80407917
82	Progressive inability to walk (HP:0002505)	1.79499382
83	Specific learning disability (HP:0001328)	1.76679407
84	Thyroid-stimulating hormone excess (HP:0002925)	1.76277638
85	Hypoplasia of the pons (HP:0012110)	1.76044913
86	Excessive salivation (HP:0003781)	1.75655631
87	Focal motor seizures (HP:0011153)	1.75393440
88	Focal seizures (HP:0007359)	1.75336950
89	Fair hair (HP:0002286)	1.75185347
90	Abnormal biliary tract physiology (HP:0012439)	1.74930561
91	Bile duct proliferation (HP:0001408)	1.74930561
92	Decreased central vision (HP:0007663)	1.74407338
93	Narrow forehead (HP:0000341)	1.74088661
94	Dandy-Walker malformation (HP:0001305)	1.74062360
95	Severe muscular hypotonia (HP:0006829)	1.73763941
96	Short foot (HP:0001773)	1.73733217
97	Abnormality of the labia minora (HP:0012880)	1.73592769
98	Occipital encephalocele (HP:0002085)	1.73033910
99	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71075406
100	Polyphagia (HP:0002591)	1.70603366

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.54907250
2	ADRBK2	3.30749403
3	CASK	3.11318589
4	BMPR1B	2.82193080
5	GRK1	2.49106045
6	ACVR1B	2.44706533
7	WNK4	2.28951578
8	PNCK	2.22758426
9	WNK3	2.18982575
10	TAOK3	2.15531649
11	NTRK3	2.15226686
12	PINK1	2.10727790
13	MAP3K4	2.05478083
14	ZAK	2.00274281
15	INSRR	1.94532072
16	NUAK1	1.93841449
17	MARK1	1.88743320
18	MAPK13	1.85274606
19	MAP4K2	1.81638363
20	TLK1	1.77448944
21	OXSR1	1.56660639
22	MAP2K7	1.51911318
23	DYRK2	1.41540116
24	SIK2	1.36729766
25	PAK3	1.34053854
26	PIK3CA	1.28260964
27	STK39	1.26423016
28	ADRBK1	1.26305481
29	NTRK2	1.21433859
30	TNIK	1.19603861
31	PRKCG	1.17070563
32	MAPK15	1.16646242
33	CDK19	1.16573416
34	MKNK2	1.14751598
35	DAPK2	1.12898418
36	TGFBR1	0.92451913
37	TIE1	0.90723932
38	EPHA4	0.86472664
39	CAMKK2	0.82536614
40	PRKCE	0.79897911
41	TYRO3	0.79126368
42	CAMK1G	0.78239860
43	STK16	0.78155711
44	CSNK1G2	0.76148177
45	CAMK1	0.70690175
46	STK3	0.69113203
47	WNK1	0.68877524
48	SGK494	0.68810899
49	SGK223	0.68810899
50	TRIM28	0.68702017
51	MAP2K4	0.66017728
52	SGK2	0.65924085
53	MINK1	0.64242987
54	PTK2B	0.63284564
55	PHKG2	0.63212422
56	PHKG1	0.63212422
57	STK11	0.63115674
58	PKN1	0.61085940
59	CAMK1D	0.59739661
60	AKT3	0.59638838
61	CAMK2A	0.59123120
62	EPHB2	0.58997802
63	MUSK	0.58222277
64	PLK2	0.58055988
65	PLK4	0.57785266
66	NEK2	0.57317052
67	PRKACA	0.55611766
68	CHUK	0.54765529
69	TEC	0.53385301
70	CSNK1G1	0.52939146
71	IRAK1	0.52422299
72	VRK1	0.52161073
73	PRKCQ	0.51422009
74	BCR	0.50949215
75	CSNK1G3	0.49773289
76	OBSCN	0.47516429
77	RPS6KA5	0.46976791
78	RPS6KA6	0.46714380
79	TXK	0.46158957
80	PRKCZ	0.45258095
81	MAP3K9	0.44506503
82	STK38L	0.44251586
83	CSNK1E	0.43626485
84	DYRK1A	0.42311165
85	CSNK1A1	0.42310452
86	CSNK1A1L	0.41887010
87	PRKCH	0.40463999
88	PRKAA1	0.40312146
89	CDC7	0.38654999
90	SGK1	0.38575374
91	PRKG1	0.37921298
92	MAP2K6	0.37576243
93	ERBB2	0.37493316
94	PLK1	0.36732046
95	CSNK1D	0.36323514
96	CDK5	0.35570455
97	BCKDK	0.34148169
98	DYRK3	0.33989449
99	PRKCA	0.32913541
100	PRKACB	0.32582349

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.96300048
2	Phototransduction_Homo sapiens_hsa04744	2.88166214
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61742601
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47620450
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.46240717
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.36573075
7	Butanoate metabolism_Homo sapiens_hsa00650	2.34352682
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.19519474
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17583916
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12098399
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09640861
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03597462
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.94606014
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.83348432
15	Morphine addiction_Homo sapiens_hsa05032	1.80826117
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77695919
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.75922755
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74312884
19	Taste transduction_Homo sapiens_hsa04742	1.70941201
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.65168093
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59413025
22	Homologous recombination_Homo sapiens_hsa03440	1.57281250
23	Olfactory transduction_Homo sapiens_hsa04740	1.56627986
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.54129814
25	Parkinsons disease_Homo sapiens_hsa05012	1.52392390
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.46688156
27	Insulin secretion_Homo sapiens_hsa04911	1.46388165
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45732095
29	Circadian entrainment_Homo sapiens_hsa04713	1.44059502
30	GABAergic synapse_Homo sapiens_hsa04727	1.40147152
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33829079
32	Serotonergic synapse_Homo sapiens_hsa04726	1.30318431
33	Protein export_Homo sapiens_hsa03060	1.29477123
34	Caffeine metabolism_Homo sapiens_hsa00232	1.23277670
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22778315
36	ABC transporters_Homo sapiens_hsa02010	1.20737951
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15500604
38	Huntingtons disease_Homo sapiens_hsa05016	1.14832212
39	Basal transcription factors_Homo sapiens_hsa03022	1.14237316
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13799856
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13302975
42	RNA polymerase_Homo sapiens_hsa03020	1.12486886
43	Dopaminergic synapse_Homo sapiens_hsa04728	1.10407176
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07400028
45	Ribosome_Homo sapiens_hsa03010	1.05549773
46	Peroxisome_Homo sapiens_hsa04146	1.04974379
47	Alzheimers disease_Homo sapiens_hsa05010	1.03819177
48	Retinol metabolism_Homo sapiens_hsa00830	0.98898736
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97572033
50	Cocaine addiction_Homo sapiens_hsa05030	0.94737830
51	Propanoate metabolism_Homo sapiens_hsa00640	0.94089348
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93220716
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92053748
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90762730
55	Regulation of autophagy_Homo sapiens_hsa04140	0.88849519
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88705914
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86214435
58	Long-term depression_Homo sapiens_hsa04730	0.85335056
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85214425
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84499595
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83747074
62	RNA degradation_Homo sapiens_hsa03018	0.82748004
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.81964386
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81753033
65	Cholinergic synapse_Homo sapiens_hsa04725	0.80929936
66	Histidine metabolism_Homo sapiens_hsa00340	0.80408338
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.80179192
68	Salivary secretion_Homo sapiens_hsa04970	0.79836894
69	Axon guidance_Homo sapiens_hsa04360	0.78502894
70	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77466700
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73413928
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71386550
73	Gastric acid secretion_Homo sapiens_hsa04971	0.71325735
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.69805043
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69541934
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63717719
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.60045954
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58217557
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.57334824
80	Amphetamine addiction_Homo sapiens_hsa05031	0.56734571
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53860918
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.52239405
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50349965
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.48898338
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48823043
86	Metabolic pathways_Homo sapiens_hsa01100	0.48162231
87	One carbon pool by folate_Homo sapiens_hsa00670	0.47172389
88	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.43506416
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41894622
90	Sulfur relay system_Homo sapiens_hsa04122	0.41421211
91	Mineral absorption_Homo sapiens_hsa04978	0.41281701
92	Purine metabolism_Homo sapiens_hsa00230	0.38504061
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36480926
94	Pancreatic secretion_Homo sapiens_hsa04972	0.35559741
95	Fatty acid degradation_Homo sapiens_hsa00071	0.33561986
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33038720
97	Bile secretion_Homo sapiens_hsa04976	0.32345143
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32227711
99	MAPK signaling pathway_Homo sapiens_hsa04010	0.31015399
100	Ras signaling pathway_Homo sapiens_hsa04014	0.30659045

SPINK9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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