SPINT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)7.79999789
2polyketide metabolic process (GO:0030638)5.64402372
3doxorubicin metabolic process (GO:0044598)5.64402372
4daunorubicin metabolic process (GO:0044597)5.64402372
5Golgi transport vesicle coating (GO:0048200)5.45518898
6COPI coating of Golgi vesicle (GO:0048205)5.45518898
7interferon-gamma secretion (GO:0072643)5.18837748
8desmosome organization (GO:0002934)4.87490854
9regulation of water loss via skin (GO:0033561)4.64765770
10intestinal absorption (GO:0050892)4.64629487
11hormone catabolic process (GO:0042447)4.54150460
12aminoglycoside antibiotic metabolic process (GO:0030647)4.51660003
13GDP-mannose metabolic process (GO:0019673)4.45530515
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.31797960
15regulation of apoptotic process involved in morphogenesis (GO:1902337)4.29581135
16intestinal cholesterol absorption (GO:0030299)4.22236269
17glandular epithelial cell differentiation (GO:0002067)4.12904088
18trophectodermal cell differentiation (GO:0001829)4.09647866
19UDP-N-acetylglucosamine metabolic process (GO:0006047)4.09127542
20somite rostral/caudal axis specification (GO:0032525)4.04483312
21columnar/cuboidal epithelial cell development (GO:0002066)4.02490036
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.98403899
23negative regulation of epidermis development (GO:0045683)3.97765723
24establishment of skin barrier (GO:0061436)3.93063479
25multicellular organismal water homeostasis (GO:0050891)3.92488635
26muscle organ morphogenesis (GO:0048644)3.90654949
27cytidine catabolic process (GO:0006216)3.84420988
28cytidine deamination (GO:0009972)3.84420988
29cytidine metabolic process (GO:0046087)3.84420988
30hemidesmosome assembly (GO:0031581)3.81126585
31protein retention in ER lumen (GO:0006621)3.76336394
32signal transduction involved in regulation of gene expression (GO:0023019)3.70139173
33branching involved in mammary gland duct morphogenesis (GO:0060444)3.69759912
34negative regulation of keratinocyte proliferation (GO:0010839)3.68850963
35gap junction assembly (GO:0016264)3.64971038
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.60896426
37surfactant homeostasis (GO:0043129)3.60806283
38epithelial cell differentiation involved in prostate gland development (GO:0060742)3.59206607
39NADH metabolic process (GO:0006734)3.58042764
40negative regulation of epidermal cell differentiation (GO:0045605)3.56566950
41endocrine pancreas development (GO:0031018)3.52644577
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.52110462
43keratinocyte proliferation (GO:0043616)3.51475207
44nucleotide-sugar biosynthetic process (GO:0009226)3.49523800
45regulation of cholesterol homeostasis (GO:2000188)3.47475841
46proline biosynthetic process (GO:0006561)3.46704240
47activation of Rac GTPase activity (GO:0032863)3.36604767
48negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.36491354
49peptide catabolic process (GO:0043171)3.32709374
50positive regulation of keratinocyte differentiation (GO:0045618)3.32697456
51positive regulation of Cdc42 GTPase activity (GO:0043089)3.32461468
52amyloid precursor protein catabolic process (GO:0042987)3.29013273
53vitamin A metabolic process (GO:0006776)3.28903975
54regulation of keratinocyte differentiation (GO:0045616)3.27778637
55regulation of keratinocyte proliferation (GO:0010837)3.20812230
56peptide hormone processing (GO:0016486)3.19722108
57cell-substrate junction assembly (GO:0007044)3.18390973
58amyloid precursor protein metabolic process (GO:0042982)3.17066497
59COPII vesicle coating (GO:0048208)3.16355152
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.16142927
61negative regulation of cell fate specification (GO:0009996)3.14052507
62regulation of hippo signaling (GO:0035330)3.13801994
63planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13709358
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11416112
65diol metabolic process (GO:0034311)3.11330589
66cellular response to vitamin D (GO:0071305)3.08921766
67peptidyl-tyrosine autophosphorylation (GO:0038083)3.08785110
68water homeostasis (GO:0030104)3.08549231
69renal absorption (GO:0070293)3.08422884
70angiotensin maturation (GO:0002003)3.06772229
71positive regulation of epidermal cell differentiation (GO:0045606)3.05025290
72sphingomyelin metabolic process (GO:0006684)3.04011557
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.02100507
74regulation of cardioblast differentiation (GO:0051890)3.01623997
75modified amino acid transport (GO:0072337)2.98861940
76regulation of chemokine secretion (GO:0090196)2.98070218
77cell-cell junction assembly (GO:0007043)2.98008009
78maintenance of protein localization in organelle (GO:0072595)2.96427292
79regulation of gene silencing by RNA (GO:0060966)2.96366880
80regulation of posttranscriptional gene silencing (GO:0060147)2.96366880
81regulation of gene silencing by miRNA (GO:0060964)2.96366880
82digestion (GO:0007586)2.95932252
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95598788
84tight junction assembly (GO:0070830)2.94746309
85chemical homeostasis within a tissue (GO:0048875)2.94626408
86sulfur compound transport (GO:0072348)2.94338713
87primitive streak formation (GO:0090009)2.93462268
88histone H4-K12 acetylation (GO:0043983)2.91746431
89exocrine pancreas development (GO:0031017)2.89597512
90negative regulation of cell cycle G2/M phase transition (GO:1902750)2.89017218
91intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.88094359
92notochord development (GO:0030903)2.87286771
93activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85988205
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85157705
95keratinocyte development (GO:0003334)2.83504335
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83056483
97ear development (GO:0043583)2.82509608
98L-alpha-amino acid transmembrane transport (GO:1902475)2.82323475
99regulation of transforming growth factor beta1 production (GO:0032908)2.81713400
100semaphorin-plexin signaling pathway (GO:0071526)2.80290926
101regulation of translation in response to stress (GO:0043555)2.80129428
102negative regulation of cell fate commitment (GO:0010454)2.80002412
103nucleoside transmembrane transport (GO:1901642)2.78725674
104thyroid hormone generation (GO:0006590)2.76975766
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76763054
106atrioventricular valve morphogenesis (GO:0003181)2.76309510
107negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.74633795
108positive regulation of nuclease activity (GO:0032075)2.72622513
109regulation of epidermis development (GO:0045682)2.72421142
110keratinization (GO:0031424)2.72092997
111negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.71976967
112regulation of viral release from host cell (GO:1902186)2.71695361
113positive regulation of epidermis development (GO:0045684)2.71492848
114phosphatidylserine acyl-chain remodeling (GO:0036150)2.71049924
115positive regulation of glycoprotein metabolic process (GO:1903020)2.70963470
116thyroid hormone metabolic process (GO:0042403)2.70823342
117urea cycle (GO:0000050)2.70411074
118glycoside metabolic process (GO:0016137)2.69956443
119epithelial cell-cell adhesion (GO:0090136)2.69848885
120positive regulation of pseudopodium assembly (GO:0031274)2.68620860
121branching involved in salivary gland morphogenesis (GO:0060445)2.68511503
122vitamin transmembrane transport (GO:0035461)2.67065985
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.67064024
124renal system process involved in regulation of blood volume (GO:0001977)2.67013237
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.66413679
126regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.65737873
127O-glycan processing (GO:0016266)2.65326349
128transepithelial transport (GO:0070633)2.65169050
129mammary gland epithelial cell differentiation (GO:0060644)2.64054072
130maternal placenta development (GO:0001893)2.63816360
131maintenance of gastrointestinal epithelium (GO:0030277)2.62642090
132intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.61408478
133regulation of epidermal cell differentiation (GO:0045604)2.59731856
134regulation of telomere maintenance via telomerase (GO:0032210)2.57990579
135phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57599412
136ventricular cardiac muscle cell action potential (GO:0086005)2.56816384
137regulation of bile acid biosynthetic process (GO:0070857)2.55918559
138keratinocyte differentiation (GO:0030216)2.55854101
139L-ascorbic acid metabolic process (GO:0019852)2.55723479
140mammary gland alveolus development (GO:0060749)2.55371734
141regulation of Cdc42 GTPase activity (GO:0043088)2.55130369
142proline metabolic process (GO:0006560)2.54917652
143morphogenesis of embryonic epithelium (GO:0016331)2.54662779
144hepatocyte apoptotic process (GO:0097284)2.54355000
145regulation of nuclease activity (GO:0032069)2.54221554
146negative regulation of bone resorption (GO:0045779)2.54110161
147polarized epithelial cell differentiation (GO:0030859)2.54079531
148establishment of apical/basal cell polarity (GO:0035089)2.53527824
149ectoderm development (GO:0007398)2.53176023
150sphingoid metabolic process (GO:0046519)2.53042142
151regulation of cholesterol biosynthetic process (GO:0045540)2.52889309
152endosome organization (GO:0007032)2.51869968
153phenol-containing compound catabolic process (GO:0019336)2.51602900
154regulation of transforming growth factor beta2 production (GO:0032909)2.51312238
155protein autoprocessing (GO:0016540)2.50767488
156glutamine family amino acid biosynthetic process (GO:0009084)2.48987458
157adherens junction assembly (GO:0034333)2.47812447
158protein localization to endosome (GO:0036010)2.47767243
159epidermal cell differentiation (GO:0009913)2.46715397
160glutathione biosynthetic process (GO:0006750)2.46479197
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45440513
162establishment or maintenance of apical/basal cell polarity (GO:0035088)2.45278312
163establishment or maintenance of bipolar cell polarity (GO:0061245)2.45278312
164glucose 6-phosphate metabolic process (GO:0051156)2.43320320
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43066975
166epidermis development (GO:0008544)2.42832619
167apical protein localization (GO:0045176)2.42673946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.91999709
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.60668454
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.60668454
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.60668454
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43310149
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62207245
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52553706
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.47748040
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38374102
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.36204227
11TCF3_18692474_ChIP-Seq_MEFs_Mouse2.32620872
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.29414322
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.21662413
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.16871521
15* CDX2_20551321_ChIP-Seq_CACO-2_Human2.08614069
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08167578
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.01296707
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98116393
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96763012
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95249115
21* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93740408
22* GATA6_25053715_ChIP-Seq_YYC3_Human1.90769720
23TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88421752
24* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86241737
25GATA4_25053715_ChIP-Seq_YYC3_Human1.84480359
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82358848
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79664004
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72054204
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68117068
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.67376852
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64176926
32* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60624393
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60596560
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58380967
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.54141662
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53759285
37* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53152519
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.52199674
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50727108
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.49280060
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48798394
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46862136
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46772559
44* ATF3_27146783_Chip-Seq_COLON_Human1.42689746
45* FOXO3_23340844_ChIP-Seq_DLD1_Human1.40126946
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.39830452
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37499466
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.37345614
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37039898
50* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36185292
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35115809
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34142902
53CREB1_26743006_Chip-Seq_LNCaP_Human1.33656823
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32521120
55* SOX2_20726797_ChIP-Seq_SW620_Human1.31390658
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30933886
57* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29176581
58* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28319505
59* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27087554
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25910096
61EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23798789
62TCF7_22412390_ChIP-Seq_EML_Mouse1.22857186
63* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22750881
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22124302
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21624535
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.21581194
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21414838
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19556529
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.18746879
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.16985026
71TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16063704
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15790583
73KDM2B_26808549_Chip-Seq_K562_Human1.14971374
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13949273
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.13694966
76SMC4_20622854_ChIP-Seq_HELA_Human1.12097889
77VDR_21846776_ChIP-Seq_THP-1_Human1.11969698
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11758017
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.11157028
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07796984
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07142899
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06924028
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05743487
84* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05247126
85KLF5_25053715_ChIP-Seq_YYC3_Human1.04996237
86* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04586138
87ELF5_23300383_ChIP-Seq_T47D_Human1.04208944
88P68_20966046_ChIP-Seq_HELA_Human1.03320999
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03302708
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03289500
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02775121
92* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02240014
93* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02223891
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01649912
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01246261
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01246261
97AR_21909140_ChIP-Seq_LNCAP_Human1.01170345
98* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.00792942
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00707390
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99185093
101KAP1_27257070_Chip-Seq_ESCs_Mouse0.98018913
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.97656510
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.96167987
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94816121
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93887331
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93774858
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93368279
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93025745
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92908748
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92766634
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92463164
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92396555
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91999510
114BCOR_27268052_Chip-Seq_Bcells_Human0.91141913
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91045152
116LXR_22292898_ChIP-Seq_THP-1_Human0.90850504
117CTCF_27219007_Chip-Seq_Bcells_Human0.90161541
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.90009593
119CHD1_26751641_Chip-Seq_LNCaP_Human0.89783895
120AHR_22903824_ChIP-Seq_MCF-7_Human0.88684994
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88603843
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87308759
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87207113
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87136875
125* NCOR1_26117541_ChIP-Seq_K562_Human0.86650148
126E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86409131
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86400835
128E2F7_22180533_ChIP-Seq_HELA_Human0.84419922
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83425613
130CLOCK_20551151_ChIP-Seq_293T_Human0.81695591
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81453286
132ZNF263_19887448_ChIP-Seq_K562_Human0.80035693
133NANOG_16518401_ChIP-PET_MESCs_Mouse0.80004993
134TP63_22573176_ChIP-Seq_HFKS_Human0.79754298
135CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79738197
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78975730
137TFEB_21752829_ChIP-Seq_HELA_Human0.78961210
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78465476
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78031670
140* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77563341
141MYC_22102868_ChIP-Seq_BL_Human0.77291313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.58046133
2* MP0004264_abnormal_extraembryonic_tissu4.08153875
3MP0002254_reproductive_system_inflammat3.88780069
4MP0000566_synostosis3.20119481
5MP0003183_abnormal_peptide_metabolism2.88557850
6MP0004043_abnormal_pH_regulation2.80256543
7MP0010352_gastrointestinal_tract_polyps2.72220201
8MP0000678_abnormal_parathyroid_gland2.58557227
9MP0002796_impaired_skin_barrier2.55198214
10MP0002877_abnormal_melanocyte_morpholog2.50843383
11MP0003283_abnormal_digestive_organ2.46391654
12MP0001849_ear_inflammation2.28171846
13MP0001666_abnormal_nutrient_absorption2.19933656
14MP0003705_abnormal_hypodermis_morpholog1.99801562
15MP0005257_abnormal_intraocular_pressure1.95120761
16MP0010678_abnormal_skin_adnexa1.93197809
17MP0003191_abnormal_cellular_cholesterol1.92205169
18* MP0002098_abnormal_vibrissa_morphology1.91907136
19MP0005409_darkened_coat_color1.79841213
20MP0004957_abnormal_blastocyst_morpholog1.77608670
21MP0003453_abnormal_keratinocyte_physiol1.73755951
22MP0003890_abnormal_embryonic-extraembry1.73149128
23MP0005451_abnormal_body_composition1.72414522
24MP0003693_abnormal_embryo_hatching1.68898560
25MP0002277_abnormal_respiratory_mucosa1.67230337
26MP0003300_gastrointestinal_ulcer1.65206074
27MP0000490_abnormal_crypts_of1.61194570
28MP0003941_abnormal_skin_development1.58898178
29MP0005501_abnormal_skin_physiology1.51063134
30MP0000537_abnormal_urethra_morphology1.49315020
31MP0005310_abnormal_salivary_gland1.47292452
32MP0009643_abnormal_urine_homeostasis1.45509330
33MP0005220_abnormal_exocrine_pancreas1.43136384
34MP0004019_abnormal_vitamin_homeostasis1.41353786
35MP0002693_abnormal_pancreas_physiology1.41328570
36MP0004782_abnormal_surfactant_physiolog1.41200168
37MP0003866_abnormal_defecation1.40667751
38MP0003566_abnormal_cell_adhesion1.39400080
39MP0001881_abnormal_mammary_gland1.39066928
40MP0000462_abnormal_digestive_system1.36938319
41MP0000383_abnormal_hair_follicle1.35680026
42MP0000377_abnormal_hair_follicle1.33132943
43* MP0001216_abnormal_epidermal_layer1.31683953
44MP0009379_abnormal_foot_pigmentation1.31053375
45MP0005394_taste/olfaction_phenotype1.29786739
46MP0005499_abnormal_olfactory_system1.29786739
47MP0000613_abnormal_salivary_gland1.29004592
48MP0000762_abnormal_tongue_morphology1.27725782
49MP0005083_abnormal_biliary_tract1.24562351
50MP0009780_abnormal_chondrocyte_physiolo1.21892523
51MP0001873_stomach_inflammation1.21563843
52MP0003119_abnormal_digestive_system1.19081551
53MP0000477_abnormal_intestine_morphology1.18276980
54MP0003878_abnormal_ear_physiology1.18072806
55MP0005377_hearing/vestibular/ear_phenot1.18072806
56MP0008260_abnormal_autophagy1.16089628
57MP0005367_renal/urinary_system_phenotyp1.15964928
58MP0000516_abnormal_urinary_system1.15964928
59MP0002909_abnormal_adrenal_gland1.15850440
60MP0004947_skin_inflammation1.15042447
61MP0002653_abnormal_ependyma_morphology1.14136686
62MP0005365_abnormal_bile_salt1.14018869
63MP0001944_abnormal_pancreas_morphology1.13983852
64MP0008961_abnormal_basal_metabolism1.13475043
65MP0010155_abnormal_intestine_physiology1.10924462
66* MP0009931_abnormal_skin_appearance1.10899133
67MP0001756_abnormal_urination1.09048791
68MP0010030_abnormal_orbit_morphology1.08654502
69MP0001765_abnormal_ion_homeostasis1.08536407
70MP0004381_abnormal_hair_follicle1.06745120
71MP0005076_abnormal_cell_differentiation1.05329848
72MP0000427_abnormal_hair_cycle1.03963444
73MP0002060_abnormal_skin_morphology1.03528904
74MP0009840_abnormal_foam_cell1.01947582
75MP0005085_abnormal_gallbladder_physiolo0.99777215
76MP0010386_abnormal_urinary_bladder0.97216017
77MP0002139_abnormal_hepatobiliary_system0.93299183
78MP0002138_abnormal_hepatobiliary_system0.90587459
79MP0008789_abnormal_olfactory_epithelium0.89615656
80MP0000467_abnormal_esophagus_morphology0.87351390
81MP0005023_abnormal_wound_healing0.86228868
82MP0003315_abnormal_perineum_morphology0.84503340
83MP0004858_abnormal_nervous_system0.84340196
84MP0006292_abnormal_olfactory_placode0.83344626
85MP0000647_abnormal_sebaceous_gland0.83163568
86MP0005248_abnormal_Harderian_gland0.82835760
87MP0008004_abnormal_stomach_pH0.82019253
88MP0002166_altered_tumor_susceptibility0.80634831
89MP0005075_abnormal_melanosome_morpholog0.78590743
90MP0002136_abnormal_kidney_physiology0.77855680
91MP0000470_abnormal_stomach_morphology0.77827379
92MP0003252_abnormal_bile_duct0.76259926
93MP0003638_abnormal_response/metabolism_0.75747346
94MP0001346_abnormal_lacrimal_gland0.75713323
95MP0002896_abnormal_bone_mineralization0.75113273
96MP0002089_abnormal_postnatal_growth/wei0.74990719
97* MP0005380_embryogenesis_phenotype0.74894338
98* MP0001672_abnormal_embryogenesis/_devel0.74894338
99MP0000579_abnormal_nail_morphology0.74735685
100MP0000538_abnormal_urinary_bladder0.74458357
101MP0005666_abnormal_adipose_tissue0.73657003
102MP0005058_abnormal_lysosome_morphology0.71846487
103MP0001664_abnormal_digestion0.70891392
104MP0000627_abnormal_mammary_gland0.70885213
105* MP0002086_abnormal_extraembryonic_tissu0.70549489
106MP0000350_abnormal_cell_proliferation0.69426736
107MP0003806_abnormal_nucleotide_metabolis0.68557119
108MP0003045_fibrosis0.68318322
109MP0000367_abnormal_coat/_hair0.68167060
110MP0005636_abnormal_mineral_homeostasis0.66879148
111MP0005360_urolithiasis0.65778307
112MP0002092_abnormal_eye_morphology0.65540483
113MP0002085_abnormal_embryonic_tissue0.65186651
114* MP0002088_abnormal_embryonic_growth/wei0.65103219
115MP0002006_tumorigenesis0.64727757
116MP0010771_integument_phenotype0.64594951
117MP0001727_abnormal_embryo_implantation0.63688655
118* MP0003984_embryonic_growth_retardation0.63284557
119MP0005166_decreased_susceptibility_to0.62079776
120MP0000858_altered_metastatic_potential0.62029615
121MP0005275_abnormal_skin_tensile0.61986458
122MP0001293_anophthalmia0.61841765
123MP0002084_abnormal_developmental_patter0.60993059
124MP0003123_paternal_imprinting0.60290367
125MP0004185_abnormal_adipocyte_glucose0.59948363
126MP0003936_abnormal_reproductive_system0.57780312
127MP0001191_abnormal_skin_condition0.57660507
128MP0009672_abnormal_birth_weight0.54063172
129MP0002111_abnormal_tail_morphology0.52830189
130MP0005375_adipose_tissue_phenotype0.51379419
131MP0009053_abnormal_anal_canal0.51061792
132MP0000681_abnormal_thyroid_gland0.49850136

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.68392066
2Abnormality of nail color (HP:0100643)4.44966725
3Hyperactive renin-angiotensin system (HP:0000841)4.13499412
4Villous atrophy (HP:0011473)4.03781284
5Abnormality of small intestinal villus morphology (HP:0011472)4.03781284
6Right ventricular cardiomyopathy (HP:0011663)3.88640725
7Pili torti (HP:0003777)3.65011135
8Gout (HP:0001997)3.59659920
9Alopecia of scalp (HP:0002293)3.54255217
10Abnormality of chloride homeostasis (HP:0011422)3.49543928
11Bilateral microphthalmos (HP:0007633)3.42769039
12Palmoplantar hyperkeratosis (HP:0000972)3.26285608
13Symptomatic seizures (HP:0011145)3.23646100
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22071846
15Abnormality of the distal phalanges of the toes (HP:0010182)3.21100774
16Trismus (HP:0000211)3.09722603
17Multiple enchondromatosis (HP:0005701)3.02901792
18Malnutrition (HP:0004395)3.01938804
19Palmar hyperkeratosis (HP:0010765)3.01905350
20Abdominal distention (HP:0003270)3.01100603
21Onycholysis (HP:0001806)2.93311740
22Cheilitis (HP:0100825)2.88857013
23Hypoglycemic seizures (HP:0002173)2.86807692
24Amelogenesis imperfecta (HP:0000705)2.85083105
25Curly hair (HP:0002212)2.84067936
26Abnormal pancreas size (HP:0012094)2.77989054
27Ependymoma (HP:0002888)2.77228672
28Atrophic scars (HP:0001075)2.75986194
29Micronodular cirrhosis (HP:0001413)2.75265757
30Hypoglycemic coma (HP:0001325)2.74172091
31Thin bony cortex (HP:0002753)2.73259390
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.71917210
33Hepatoblastoma (HP:0002884)2.71404661
34Advanced eruption of teeth (HP:0006288)2.70132006
35Thick nail (HP:0001805)2.69997016
36Vacuolated lymphocytes (HP:0001922)2.69772954
37Congenital ichthyosiform erythroderma (HP:0007431)2.69619379
38Abnormality of the salivary glands (HP:0010286)2.69013722
39Renal salt wasting (HP:0000127)2.67755765
40Septate vagina (HP:0001153)2.63967223
41Hyperglycemia (HP:0003074)2.60069398
42Pterygium (HP:0001059)2.59380611
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.57604586
44Hypoplasia of the fovea (HP:0007750)2.57604586
45Milia (HP:0001056)2.57539235
46Woolly hair (HP:0002224)2.55442963
47Abnormality of liposaccharide metabolism (HP:0010968)2.50886685
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.50886685
49Abnormality of glycolipid metabolism (HP:0010969)2.50886685
50Distal lower limb muscle weakness (HP:0009053)2.50656665
51Hyperparathyroidism (HP:0000843)2.49802274
52Fused cervical vertebrae (HP:0002949)2.47298363
53Abnormal blistering of the skin (HP:0008066)2.43546489
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41761773
55Ridged nail (HP:0001807)2.41622903
56Lip pit (HP:0100267)2.40818879
57Abnormality of proline metabolism (HP:0010907)2.40139149
58Hydroxyprolinuria (HP:0003080)2.40139149
59Abnormality of permanent molar morphology (HP:0011071)2.40039922
60Abnormality of the dental root (HP:0006486)2.40039922
61Taurodontia (HP:0000679)2.40039922
62Hypoplastic labia majora (HP:0000059)2.36451736
63Abnormality of renin-angiotensin system (HP:0000847)2.35362530
64Rib fusion (HP:0000902)2.34932607
65Hyperaldosteronism (HP:0000859)2.32109038
66Fragile nails (HP:0001808)2.28618311
67Selective tooth agenesis (HP:0001592)2.27714579
68Abnormal biliary tract morphology (HP:0012440)2.26317035
69Hypokalemia (HP:0002900)2.25901443
70Plantar hyperkeratosis (HP:0007556)2.24258603
71Popliteal pterygium (HP:0009756)2.21297903
72Microretrognathia (HP:0000308)2.21220920
73Biliary tract neoplasm (HP:0100574)2.18886139
74Focal segmental glomerulosclerosis (HP:0000097)2.17714587
75Shawl scrotum (HP:0000049)2.16737121
76Abnormality of molar (HP:0011077)2.15418621
77Abnormality of molar morphology (HP:0011070)2.15418621
78Aplasia/hypoplasia of the humerus (HP:0006507)2.14764638
79Interstitial pulmonary disease (HP:0006530)2.13567211
80Short humerus (HP:0005792)2.13460792
81Germ cell neoplasia (HP:0100728)2.12167520
82Ileus (HP:0002595)2.11701419
83Hand muscle atrophy (HP:0009130)2.11256888
84Ventricular tachycardia (HP:0004756)2.11084984
85Dehydration (HP:0001944)2.10171111
86Ankyloglossia (HP:0010296)2.09865880
87Late onset (HP:0003584)2.08963477
88Hypoplasia of dental enamel (HP:0006297)2.08751512
89Insulin-resistant diabetes mellitus (HP:0000831)2.08218216
90Abnormality of endocrine pancreas physiology (HP:0012093)2.07711015
91Abnormality of the pancreatic islet cells (HP:0006476)2.07711015
92Abnormality of the dental pulp (HP:0006479)2.07522203
93Abnormality of the distal phalanx of the thumb (HP:0009617)2.07404324
94Acanthosis nigricans (HP:0000956)2.07381579
95Flat acetabular roof (HP:0003180)2.06994157
96Testicular atrophy (HP:0000029)2.06907347
97Aplasia cutis congenita (HP:0001057)2.06206585
98Abnormality of the labia majora (HP:0012881)2.05983832
99Urinary glycosaminoglycan excretion (HP:0003541)2.05683030
100Mucopolysacchariduria (HP:0008155)2.05683030
101Glomerulosclerosis (HP:0000096)2.03911950
102Natal tooth (HP:0000695)2.03352008
103Hyperphosphatemia (HP:0002905)2.01450633
104Hypotension (HP:0002615)2.00783251
105Dysostosis multiplex (HP:0000943)1.98864093
106Abnormality of the fovea (HP:0000493)1.98802441
107Abnormality of calcium-phosphate metabolism (HP:0100530)1.96292624
108Ketoacidosis (HP:0001993)1.95447068
109Pustule (HP:0200039)1.95164391
110Abnormal cartilage morphology (HP:0002763)1.94416487
111Sparse eyelashes (HP:0000653)1.93687710
112Abnormal tarsal ossification (HP:0008369)1.93614736
113Vascular calcification (HP:0004934)1.93501456
114Mildly elevated creatine phosphokinase (HP:0008180)1.93252869
115Gastrointestinal carcinoma (HP:0002672)1.92652678
116Malignant gastrointestinal tract tumors (HP:0006749)1.92652678
117Abnormal hemoglobin (HP:0011902)1.91668677
118Bone pain (HP:0002653)1.91252990
119Hyperglycinuria (HP:0003108)1.91043395
120Upper limb muscle weakness (HP:0003484)1.90872192
121Widely patent fontanelles and sutures (HP:0004492)1.89972663
122Sparse lateral eyebrow (HP:0005338)1.89949601
123Fat malabsorption (HP:0002630)1.88636270
124Unilateral renal agenesis (HP:0000122)1.88007012
125Chronic bronchitis (HP:0004469)1.87913624
126Flattened epiphyses (HP:0003071)1.87641952
127Nail dystrophy (HP:0008404)1.87015919
128Increased purine levels (HP:0004368)1.86887298
129Hyperuricemia (HP:0002149)1.86887298
130Decreased circulating renin level (HP:0003351)1.86800122
131Absent eyelashes (HP:0000561)1.86609459
132Abnormality of the gastric mucosa (HP:0004295)1.86495607
133Osteomalacia (HP:0002749)1.85976866
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85926153
135Cervical subluxation (HP:0003308)1.85871773
136Hyponatremia (HP:0002902)1.85459433
137Abnormality of the intrinsic pathway (HP:0010989)1.84968530
138Premature loss of primary teeth (HP:0006323)1.84298615
139Hypotrichosis (HP:0001006)1.84017551
140Fragile skin (HP:0001030)1.82962998
141Aplasia/hypoplasia of the uterus (HP:0008684)1.82921393
142Bronchomalacia (HP:0002780)1.82628417
143Missing ribs (HP:0000921)1.82200617
144Abnormal hair laboratory examination (HP:0003328)1.81768000
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81666833
146Reduced antithrombin III activity (HP:0001976)1.81325404
147Spinal muscular atrophy (HP:0007269)1.81109701
148Skin pits (HP:0100276)1.81101972
149Intrahepatic cholestasis (HP:0001406)1.76007197
150Broad face (HP:0000283)1.75743066
151Sparse scalp hair (HP:0002209)1.73534339
152Wide cranial sutures (HP:0010537)1.72299119
153Hypophosphatemia (HP:0002148)1.71690373
154Corneal erosion (HP:0200020)1.71540416
155Distal upper limb amyotrophy (HP:0007149)1.70465606
156Upper limb amyotrophy (HP:0009129)1.70465606
157Axonal loss (HP:0003447)1.70326092
158Distal lower limb amyotrophy (HP:0008944)1.69437678
159Short nail (HP:0001799)1.67085499
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.65407920
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.65307678
162Osteolytic defects of the hand bones (HP:0009699)1.65307678
163Abnormality of carpal bone ossification (HP:0006257)1.65162213
164Renal tubular acidosis (HP:0001947)1.64672280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.05083829
2CDK124.47130630
3ERN14.18941197
4SIK13.39798618
5MST43.05862659
6SMG12.88074646
7MAPK152.73209159
8MAP2K22.69314662
9FRK2.51093562
10MAP3K22.10294486
11MST1R1.99754063
12GRK61.93065335
13PASK1.92292821
14TTK1.90876403
15MAP3K31.87037838
16STK101.84322121
17WNK31.79887538
18GRK51.76592919
19RIPK11.73710635
20PAK41.73279843
21PTK21.70125519
22GRK11.68151484
23TGFBR21.59575955
24PRKCI1.57732543
25RPS6KB21.57160061
26AKT31.56280084
27WNK41.54389544
28PRKG21.49060278
29EEF2K1.48913844
30PKN21.48552554
31INSRR1.46438594
32MET1.42123142
33MATK1.39472683
34HIPK21.38151778
35MAPKAPK31.36947630
36FER1.35415943
37NME21.32454491
38PTK61.27826202
39MAP3K121.23745361
40LATS21.22128073
41STK241.19851896
42TESK21.17409074
43ADRBK21.11100626
44STK38L1.08300200
45TAOK31.07508124
46ICK1.04855302
47NME11.03443028
48MAP3K91.01534210
49WNK10.98738370
50LATS10.97558216
51TESK10.92509326
52IRAK30.90029117
53SCYL20.86705894
54DYRK1B0.84972180
55PBK0.83287870
56NTRK10.82812280
57BMX0.80236829
58ARAF0.79421420
59CDK70.78007874
60EPHA30.76245717
61STK390.74836181
62EPHB10.74108216
63CHUK0.73663335
64CSF1R0.72443828
65TYRO30.71206720
66PRKD20.70528073
67PIK3CG0.67890958
68FLT30.65576488
69PIK3CA0.64648889
70MAP2K60.64505200
71RPS6KA20.64059574
72NEK60.62328200
73CHEK20.61418843
74CSK0.60262382
75MTOR0.59277347
76MAP3K80.58947902
77GRK70.57983146
78MAP2K10.57461210
79DYRK30.57048836
80TBK10.56685891
81EPHB20.55822298
82NLK0.55808862
83PIM20.55764795
84MAP3K10.52922363
85STK380.52284399
86ILK0.52278413
87AURKB0.51879529
88MAP3K60.51197530
89TAOK10.51166576
90TRIB30.51056893
91MAPK70.50721348
92PRPF4B0.50370931
93RPS6KA40.49765539
94LMTK20.49599879
95MAP3K130.47437987
96MAP3K100.46768739
97PLK10.46582540
98ERBB20.45281388
99CAMK1D0.44968734
100LRRK20.44219430
101PDPK10.43231982
102DMPK0.43057290
103FGFR30.42820562
104GSK3A0.42267574
105MOS0.41360289
106BCKDK0.40320377
107PDGFRA0.38304283
108MAPKAPK20.37453453
109CDC42BPA0.37335693
110ZAP700.36882752
111RET0.35794485
112BUB10.35697231
113ACVR1B0.34365091
114EIF2AK30.32858685
115KSR20.32446778
116RPS6KC10.31645204
117RPS6KL10.31645204
118ALK0.31484308
119PRKD30.30646859
120IKBKB0.29910524
121OXSR10.29908473
122DDR20.29649260
123VRK20.29552979
124SIK30.28960414
125AURKA0.28092898
126PAK30.27555427
127DAPK10.27326355
128BRSK20.27260662
129FGFR40.27064934
130MARK20.27028673
131MAP3K110.25686243
132ZAK0.25465698
133CDK60.25389858
134CAMK2G0.24818270
135PRKCD0.24646277
136EIF2AK10.24234368
137AKT20.23672634
138NEK20.23660594
139IRAK20.23084047
140PAK10.22956125
141IRAK10.22146780
142PDGFRB0.20198163
143STK30.20094017
144MUSK0.19868982
145PRKAA20.19846015
146CDK90.18369393

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.68914276
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.61339554
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.40430370
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.87540261
5Galactose metabolism_Homo sapiens_hsa000522.70051448
6Fructose and mannose metabolism_Homo sapiens_hsa000512.66575370
7Other glycan degradation_Homo sapiens_hsa005112.63251447
8Sulfur metabolism_Homo sapiens_hsa009202.62353502
9Fat digestion and absorption_Homo sapiens_hsa049752.54350180
10Folate biosynthesis_Homo sapiens_hsa007902.49129730
11Mineral absorption_Homo sapiens_hsa049782.10941314
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99631679
13Renin-angiotensin system_Homo sapiens_hsa046141.93706640
14Protein export_Homo sapiens_hsa030601.89388818
15Arachidonic acid metabolism_Homo sapiens_hsa005901.88967035
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.87853573
17Protein digestion and absorption_Homo sapiens_hsa049741.87539667
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83826521
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78747559
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77568957
21Arginine biosynthesis_Homo sapiens_hsa002201.76769283
22Linoleic acid metabolism_Homo sapiens_hsa005911.70196456
23Vitamin digestion and absorption_Homo sapiens_hsa049771.51067295
24Lysosome_Homo sapiens_hsa041421.44787980
25Tight junction_Homo sapiens_hsa045301.39408316
26Thyroid cancer_Homo sapiens_hsa052161.34365200
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33026467
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32711115
29Pancreatic secretion_Homo sapiens_hsa049721.32175969
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29698606
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29387320
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25808181
33Selenocompound metabolism_Homo sapiens_hsa004501.21318373
34Bladder cancer_Homo sapiens_hsa052191.19553889
35Vibrio cholerae infection_Homo sapiens_hsa051101.14819109
36Sphingolipid metabolism_Homo sapiens_hsa006001.13384831
37Adherens junction_Homo sapiens_hsa045201.10523169
38Starch and sucrose metabolism_Homo sapiens_hsa005001.06536710
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.03738538
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01349028
41Glutathione metabolism_Homo sapiens_hsa004800.99142936
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95531216
43PPAR signaling pathway_Homo sapiens_hsa033200.92495912
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92249773
45Fatty acid biosynthesis_Homo sapiens_hsa000610.90691957
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.90382975
47Histidine metabolism_Homo sapiens_hsa003400.89811889
48Antigen processing and presentation_Homo sapiens_hsa046120.86438069
49Amoebiasis_Homo sapiens_hsa051460.85075904
50Retinol metabolism_Homo sapiens_hsa008300.84218786
51Regulation of autophagy_Homo sapiens_hsa041400.84120479
52Vitamin B6 metabolism_Homo sapiens_hsa007500.83692763
53Legionellosis_Homo sapiens_hsa051340.82049159
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80812807
55p53 signaling pathway_Homo sapiens_hsa041150.80751493
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77602300
57ECM-receptor interaction_Homo sapiens_hsa045120.77163626
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75441243
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.75165102
60Hippo signaling pathway_Homo sapiens_hsa043900.73073808
61Insulin signaling pathway_Homo sapiens_hsa049100.72531068
62Glycerolipid metabolism_Homo sapiens_hsa005610.69036762
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.68912864
64Biosynthesis of amino acids_Homo sapiens_hsa012300.68706978
65N-Glycan biosynthesis_Homo sapiens_hsa005100.68123734
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66740270
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62691802
68Fatty acid degradation_Homo sapiens_hsa000710.60803983
69Chronic myeloid leukemia_Homo sapiens_hsa052200.59976496
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59767144
71Fatty acid metabolism_Homo sapiens_hsa012120.57907687
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57754634
73AMPK signaling pathway_Homo sapiens_hsa041520.57232742
74Chemical carcinogenesis_Homo sapiens_hsa052040.57140339
75Hepatitis C_Homo sapiens_hsa051600.55503936
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54958297
77Carbon metabolism_Homo sapiens_hsa012000.53661898
78Tyrosine metabolism_Homo sapiens_hsa003500.53441884
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52312164
80Fatty acid elongation_Homo sapiens_hsa000620.51599213
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.51119423
82Renal cell carcinoma_Homo sapiens_hsa052110.50981478
83Tryptophan metabolism_Homo sapiens_hsa003800.50403355
84Ether lipid metabolism_Homo sapiens_hsa005650.50365387
85ErbB signaling pathway_Homo sapiens_hsa040120.50320924
86Inositol phosphate metabolism_Homo sapiens_hsa005620.49238818
87Endocytosis_Homo sapiens_hsa041440.48184530
88Apoptosis_Homo sapiens_hsa042100.47286106
89Steroid biosynthesis_Homo sapiens_hsa001000.46940581
90VEGF signaling pathway_Homo sapiens_hsa043700.46249333
91Bile secretion_Homo sapiens_hsa049760.44920236
92Pentose phosphate pathway_Homo sapiens_hsa000300.44238534
93Toxoplasmosis_Homo sapiens_hsa051450.44085172
94Thyroid hormone synthesis_Homo sapiens_hsa049180.44025195
95Focal adhesion_Homo sapiens_hsa045100.43242364
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42446706
97Pancreatic cancer_Homo sapiens_hsa052120.41815445
98mTOR signaling pathway_Homo sapiens_hsa041500.41506227
99Insulin resistance_Homo sapiens_hsa049310.38999036
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38976981
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38966856
102Small cell lung cancer_Homo sapiens_hsa052220.38595154
103RNA transport_Homo sapiens_hsa030130.38066728
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37822550
105Acute myeloid leukemia_Homo sapiens_hsa052210.37660346
106Influenza A_Homo sapiens_hsa051640.37108905
107Glucagon signaling pathway_Homo sapiens_hsa049220.36352572
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35931722
109Type II diabetes mellitus_Homo sapiens_hsa049300.35418062
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34932053
111Ribosome_Homo sapiens_hsa030100.34249397
112Sulfur relay system_Homo sapiens_hsa041220.34150661
113ABC transporters_Homo sapiens_hsa020100.33040817
114Insulin secretion_Homo sapiens_hsa049110.32651014
115Proteoglycans in cancer_Homo sapiens_hsa052050.31552254
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.31481753
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28836688
118* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28245354
119Leishmaniasis_Homo sapiens_hsa051400.27834111
120Prostate cancer_Homo sapiens_hsa052150.27327465
121Prolactin signaling pathway_Homo sapiens_hsa049170.27324790
122MicroRNAs in cancer_Homo sapiens_hsa052060.26823696
123Arginine and proline metabolism_Homo sapiens_hsa003300.26757230
124Endometrial cancer_Homo sapiens_hsa052130.26471618
125Pathways in cancer_Homo sapiens_hsa052000.25681402
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25309641
127Caffeine metabolism_Homo sapiens_hsa002320.24952929
128Phenylalanine metabolism_Homo sapiens_hsa003600.23721912
129Collecting duct acid secretion_Homo sapiens_hsa049660.22765052
130Basal cell carcinoma_Homo sapiens_hsa052170.21882606
131Notch signaling pathway_Homo sapiens_hsa043300.20590713
132Hedgehog signaling pathway_Homo sapiens_hsa043400.20059682
133Type I diabetes mellitus_Homo sapiens_hsa049400.19710401

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