SPINT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.61960151
2COPI coating of Golgi vesicle (GO:0048205)7.61960151
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.88801496
4protein retention in ER lumen (GO:0006621)5.66807427
5intestinal epithelial cell development (GO:0060576)4.79655428
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.69821819
7glandular epithelial cell differentiation (GO:0002067)4.47378617
8COPII vesicle coating (GO:0048208)4.47324995
9establishment of skin barrier (GO:0061436)4.42968490
10GDP-mannose metabolic process (GO:0019673)4.38257802
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.35518236
12endocrine pancreas development (GO:0031018)4.24220489
13signal peptide processing (GO:0006465)4.23181704
14intestinal cholesterol absorption (GO:0030299)4.15982887
15intestinal absorption (GO:0050892)4.13951646
16peptide catabolic process (GO:0043171)4.13380992
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.09467846
18protein autoprocessing (GO:0016540)4.08498991
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05389162
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05389162
21amyloid precursor protein metabolic process (GO:0042982)3.90661219
22regulation of mitochondrial translation (GO:0070129)3.90513659
23regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.84456833
24exocrine pancreas development (GO:0031017)3.83428015
25amyloid precursor protein catabolic process (GO:0042987)3.83192089
26proline biosynthetic process (GO:0006561)3.78041451
27peptide hormone processing (GO:0016486)3.75802796
28water homeostasis (GO:0030104)3.74325032
29positive regulation of epidermal cell differentiation (GO:0045606)3.72413827
30tight junction assembly (GO:0070830)3.70590621
31maintenance of gastrointestinal epithelium (GO:0030277)3.62623749
32antigen processing and presentation of endogenous antigen (GO:0019883)3.60484077
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59921733
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59520872
35protein targeting to ER (GO:0045047)3.51058210
36negative regulation of glycoprotein biosynthetic process (GO:0010561)3.49334179
37ribosomal small subunit assembly (GO:0000028)3.46842712
38cotranslational protein targeting to membrane (GO:0006613)3.45964820
39hemidesmosome assembly (GO:0031581)3.41675481
40calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.38093609
41digestion (GO:0007586)3.34782479
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.34439913
43protein localization to endoplasmic reticulum (GO:0070972)3.33062577
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31039344
45renal absorption (GO:0070293)3.25571396
46keratinocyte development (GO:0003334)3.25119053
47positive regulation of nuclease activity (GO:0032075)3.23245948
48negative regulation of erythrocyte differentiation (GO:0045647)3.22178798
49sequestering of metal ion (GO:0051238)3.21287482
50L-alpha-amino acid transmembrane transport (GO:1902475)3.18062754
51antigen processing and presentation via MHC class Ib (GO:0002475)3.14018928
52columnar/cuboidal epithelial cell development (GO:0002066)3.11698257
53positive regulation of insulin secretion (GO:0032024)3.11274595
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.11221517
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.11221517
56epithelial cell-cell adhesion (GO:0090136)3.09648602
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09068385
58regulation of cell proliferation involved in kidney development (GO:1901722)3.08131180
59sulfur amino acid catabolic process (GO:0000098)3.04377748
60ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.04119574
61hepatocyte apoptotic process (GO:0097284)3.03625160
62regulation of water loss via skin (GO:0033561)3.03227545
63protein N-linked glycosylation via asparagine (GO:0018279)3.03108941
64peptidyl-asparagine modification (GO:0018196)3.01605119
65regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.01579238
66nucleotide-sugar metabolic process (GO:0009225)3.00505834
67nucleotide-sugar biosynthetic process (GO:0009226)2.98911369
68regulation of nuclease activity (GO:0032069)2.98422179
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98349880
70positive regulation of glycoprotein metabolic process (GO:1903020)2.98336753
71positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.98094990
72glutathione biosynthetic process (GO:0006750)2.96893689
73positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.96709347
74endoplasmic reticulum unfolded protein response (GO:0030968)2.92557300
75digestive system process (GO:0022600)2.92167719
76interferon-gamma secretion (GO:0072643)2.91964506
77thyroid hormone generation (GO:0006590)2.91031959
78galactose catabolic process (GO:0019388)2.90977540
79angiotensin maturation (GO:0002003)2.90891696
80pteridine-containing compound biosynthetic process (GO:0042559)2.89799050
81gap junction assembly (GO:0016264)2.89474057
82cellular response to vitamin D (GO:0071305)2.88407684
83NADH metabolic process (GO:0006734)2.88014773
84desmosome organization (GO:0002934)2.87981357
85negative regulation of kidney development (GO:0090185)2.87696059
86regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87459404
87base-excision repair, AP site formation (GO:0006285)2.87395400
88primary alcohol catabolic process (GO:0034310)2.87159413
89thyroid hormone metabolic process (GO:0042403)2.86798196
90mammary gland alveolus development (GO:0060749)2.86358019
91cellular response to unfolded protein (GO:0034620)2.84548201
92zinc ion transmembrane transport (GO:0071577)2.84215781
93L-phenylalanine metabolic process (GO:0006558)2.83063372
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83063372
95positive regulation of epidermis development (GO:0045684)2.82879163
96positive regulation of keratinocyte differentiation (GO:0045618)2.82615772
97endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.82059130
98cellular response to topologically incorrect protein (GO:0035967)2.81698956
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.81258906
100proteasome assembly (GO:0043248)2.81237168
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.80955159
102glutathione derivative biosynthetic process (GO:1901687)2.80552949
103glutathione derivative metabolic process (GO:1901685)2.80552949
104negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.79915001
105negative regulation of digestive system process (GO:0060457)2.79829163
106establishment of apical/basal cell polarity (GO:0035089)2.79733041
107branching involved in mammary gland duct morphogenesis (GO:0060444)2.79612190
108protein maturation by protein folding (GO:0022417)2.79196866
109negative regulation of cell fate specification (GO:0009996)2.78749819
110mesonephros development (GO:0001823)2.78309596
111vesicle coating (GO:0006901)2.78256245
112regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.77585068
113multicellular organismal water homeostasis (GO:0050891)2.77543427
114glucose catabolic process (GO:0006007)2.76925442
115signal transduction involved in regulation of gene expression (GO:0023019)2.76743086
116proline metabolic process (GO:0006560)2.76560619
117protein N-linked glycosylation (GO:0006487)2.75985654
118negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75588635
119viral transcription (GO:0019083)2.74331324
120cobalamin metabolic process (GO:0009235)2.74098885
121membrane budding (GO:0006900)2.71874862
122beta-amyloid metabolic process (GO:0050435)2.69859370
123phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69704515
124DNA deamination (GO:0045006)2.69476396
125regulation of cholesterol homeostasis (GO:2000188)2.69392288
126phosphate ion homeostasis (GO:0055062)2.69283060
127trivalent inorganic anion homeostasis (GO:0072506)2.69283060
128negative regulation of T cell differentiation in thymus (GO:0033085)2.66935274
129epithelial structure maintenance (GO:0010669)2.66870387
130peptide metabolic process (GO:0006518)2.66056387
131vitamin transmembrane transport (GO:0035461)2.65806502
132translational termination (GO:0006415)2.65148460
133nonribosomal peptide biosynthetic process (GO:0019184)2.62662572
134growth hormone secretion (GO:0030252)2.62196642
135epithelial cell maturation (GO:0002070)2.62015970
136fucose metabolic process (GO:0006004)2.61632824
137phospholipid scrambling (GO:0017121)2.61607860
138response to endoplasmic reticulum stress (GO:0034976)2.61453790
139ER-nucleus signaling pathway (GO:0006984)2.60817228
140regulation of autophagic vacuole assembly (GO:2000785)2.60459198
141positive regulation of cellular amine metabolic process (GO:0033240)2.60216334
142water-soluble vitamin biosynthetic process (GO:0042364)2.59281443
143negative regulation of keratinocyte proliferation (GO:0010839)2.59253765
144regulation of cellular amino acid metabolic process (GO:0006521)2.59016418
145regulation of keratinocyte differentiation (GO:0045616)2.58229294
146O-glycan processing (GO:0016266)2.57447619
147morphogenesis of embryonic epithelium (GO:0016331)2.57088787
148regulation of respiratory burst (GO:0060263)2.55628932
149nucleoside transmembrane transport (GO:1901642)2.55322522
150mitochondrial calcium ion transport (GO:0006851)2.55242875
151sphingomyelin metabolic process (GO:0006684)2.55210382
152auditory receptor cell differentiation (GO:0042491)2.54978816
153positive regulation of peptide hormone secretion (GO:0090277)2.53744227
154myelin maintenance (GO:0043217)2.53265048
155toxin metabolic process (GO:0009404)2.53262396
156cell-cell junction assembly (GO:0007043)2.52181721
157mitotic nuclear envelope reassembly (GO:0007084)2.50983342
158nuclear envelope reassembly (GO:0031468)2.50983342
159nucleoside transport (GO:0015858)2.50773852
160nucleotide transmembrane transport (GO:1901679)2.49489450
161norepinephrine metabolic process (GO:0042415)2.49377482
162negative regulation of glycoprotein metabolic process (GO:1903019)2.47447930
163ER overload response (GO:0006983)2.47164873
164pentose-phosphate shunt (GO:0006098)2.43921548
165response to misfolded protein (GO:0051788)2.43832341
166negative regulation of protein tyrosine kinase activity (GO:0061099)2.43474753
167adenine nucleotide transport (GO:0051503)2.43285987
168pyrimidine nucleotide catabolic process (GO:0006244)2.43153446
169branching involved in salivary gland morphogenesis (GO:0060445)2.42683545
170keratinocyte proliferation (GO:0043616)2.41724739
171purine ribonucleotide transport (GO:0015868)2.41537106
172decidualization (GO:0046697)2.41335056
173prostanoid biosynthetic process (GO:0046457)2.41160834
174prostaglandin biosynthetic process (GO:0001516)2.41160834
175nitric oxide biosynthetic process (GO:0006809)2.41091521
176translational elongation (GO:0006414)2.40294270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.62840081
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.76960230
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.58175542
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52310538
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43660146
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37943561
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22654530
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.18504328
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.17478436
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13337831
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09464218
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07390326
13* GATA4_25053715_ChIP-Seq_YYC3_Human2.00064675
14ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98998928
15GATA1_22025678_ChIP-Seq_K562_Human1.97263000
16GATA6_25053715_ChIP-Seq_YYC3_Human1.90230694
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88218213
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.83464718
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81892096
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79654725
21* MYC_18555785_ChIP-Seq_MESCs_Mouse1.75551994
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.73399797
23ZNF263_19887448_ChIP-Seq_K562_Human1.72082261
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71546336
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67985205
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.67184581
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63743585
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60788213
29* SOX2_20726797_ChIP-Seq_SW620_Human1.57327662
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.55409259
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.54581084
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.53949829
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52028784
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51271130
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.49991068
36RACK7_27058665_Chip-Seq_MCF-7_Human1.49492166
37CLOCK_20551151_ChIP-Seq_293T_Human1.49040706
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48203762
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47196581
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46546124
41P68_20966046_ChIP-Seq_HELA_Human1.45061793
42ATF3_27146783_Chip-Seq_COLON_Human1.44473304
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43891907
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43567475
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42112068
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35226257
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34719849
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33974790
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33624107
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33624107
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31987873
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.29295838
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28256383
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.27364943
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.27248610
56KLF5_25053715_ChIP-Seq_YYC3_Human1.26712995
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26329118
58TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.25786089
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24516363
60MYC_22102868_ChIP-Seq_BL_Human1.24268969
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22931231
62* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22601722
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22157192
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22041666
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21927352
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21357489
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20272080
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20212980
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20095604
70* TP63_22573176_ChIP-Seq_HFKS_Human1.19950938
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19501965
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19308240
73SMC4_20622854_ChIP-Seq_HELA_Human1.17950605
74LXR_22292898_ChIP-Seq_THP-1_Human1.17152900
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16224287
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15488115
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15159532
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14474272
79XRN2_22483619_ChIP-Seq_HELA_Human1.14343347
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13822150
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12648334
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11749513
83CHD1_26751641_Chip-Seq_LNCaP_Human1.11612281
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.11600426
85GABP_19822575_ChIP-Seq_HepG2_Human1.11467415
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11075824
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10778216
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10384320
89* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10091802
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09817222
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09111795
92BCOR_27268052_Chip-Seq_Bcells_Human1.09076310
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08634280
94CREB1_26743006_Chip-Seq_LNCaP_Human1.08422554
95ELF5_23300383_ChIP-Seq_T47D_Human1.08144613
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.07813227
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07720666
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07707291
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06855583
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.06036856
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.05180680
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.04644058
103PHF8_20622854_ChIP-Seq_HELA_Human1.04622808
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04615439
105* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03770918
106DCP1A_22483619_ChIP-Seq_HELA_Human1.03708814
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03646972
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03437939
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03175887
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03147534
111GATA3_24758297_ChIP-Seq_MCF-7_Human1.02697916
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01720428
113BCL6_27268052_Chip-Seq_Bcells_Human1.01471153
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00827295
115AR_21909140_ChIP-Seq_LNCAP_Human1.00643040
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.00204329
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00003041
118* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99971605
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99728588
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99321045
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99031477
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99010276
123* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98850810
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98546941
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98356152
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.97826873
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96699545
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96635730
129CTCF_27219007_Chip-Seq_Bcells_Human0.96565749
130* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96511259
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95740107
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94872821
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93589220
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93068993
135VDR_21846776_ChIP-Seq_THP-1_Human0.93026242
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91708010
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91179490
138EST1_17652178_ChIP-ChIP_JURKAT_Human0.90214931
139KDM5A_27292631_Chip-Seq_BREAST_Human0.90083594
140* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89455975
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.89325754
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89187753
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87869022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.71609900
2MP0004264_abnormal_extraembryonic_tissu3.99306722
3MP0001666_abnormal_nutrient_absorption3.21201288
4MP0000579_abnormal_nail_morphology2.77330729
5MP0003183_abnormal_peptide_metabolism2.75475264
6MP0009780_abnormal_chondrocyte_physiolo2.74688421
7MP0005220_abnormal_exocrine_pancreas2.64441435
8MP0000566_synostosis2.64336415
9MP0005365_abnormal_bile_salt2.47904277
10MP0003866_abnormal_defecation2.39012838
11MP0000383_abnormal_hair_follicle2.33441744
12MP0004043_abnormal_pH_regulation2.30801101
13MP0001873_stomach_inflammation2.24626311
14MP0002138_abnormal_hepatobiliary_system2.21246312
15MP0003123_paternal_imprinting2.10141707
16MP0004185_abnormal_adipocyte_glucose2.08085356
17MP0002139_abnormal_hepatobiliary_system2.04590441
18MP0009643_abnormal_urine_homeostasis2.02322433
19MP0000678_abnormal_parathyroid_gland2.02184407
20MP0000462_abnormal_digestive_system2.02016786
21MP0000013_abnormal_adipose_tissue2.01057159
22MP0006054_spinal_hemorrhage1.98978712
23MP0003195_calcinosis1.98906374
24MP0003300_gastrointestinal_ulcer1.98602941
25MP0001944_abnormal_pancreas_morphology1.97230510
26MP0005360_urolithiasis1.97098334
27MP0002877_abnormal_melanocyte_morpholog1.94249022
28MP0002693_abnormal_pancreas_physiology1.87603946
29MP0005084_abnormal_gallbladder_morpholo1.83978331
30MP0003283_abnormal_digestive_organ1.79815499
31MP0004019_abnormal_vitamin_homeostasis1.77387310
32MP0005085_abnormal_gallbladder_physiolo1.76645707
33MP0002254_reproductive_system_inflammat1.74041555
34MP0000377_abnormal_hair_follicle1.73159249
35MP0000537_abnormal_urethra_morphology1.70623522
36MP0010155_abnormal_intestine_physiology1.70611280
37MP0001765_abnormal_ion_homeostasis1.70423875
38MP0010771_integument_phenotype1.68441434
39MP0001756_abnormal_urination1.67642329
40MP0005083_abnormal_biliary_tract1.66815497
41MP0000613_abnormal_salivary_gland1.64528348
42MP0000490_abnormal_crypts_of1.63347985
43MP0002909_abnormal_adrenal_gland1.61899664
44MP0008875_abnormal_xenobiotic_pharmacok1.59141025
45MP0010352_gastrointestinal_tract_polyps1.58206309
46MP0005636_abnormal_mineral_homeostasis1.55644595
47MP0003693_abnormal_embryo_hatching1.52496918
48MP0002796_impaired_skin_barrier1.50437915
49MP0008004_abnormal_stomach_pH1.49996622
50MP0001664_abnormal_digestion1.49791124
51MP0002098_abnormal_vibrissa_morphology1.49195390
52MP0005310_abnormal_salivary_gland1.43201536
53MP0002837_dystrophic_cardiac_calcinosis1.39621481
54MP0000627_abnormal_mammary_gland1.37979921
55MP0003806_abnormal_nucleotide_metabolis1.36165523
56MP0001727_abnormal_embryo_implantation1.35370218
57MP0000477_abnormal_intestine_morphology1.35154064
58MP0003252_abnormal_bile_duct1.34382029
59MP0001849_ear_inflammation1.32262598
60MP0010386_abnormal_urinary_bladder1.31529686
61MP0003868_abnormal_feces_composition1.31438766
62MP0005379_endocrine/exocrine_gland_phen1.27497490
63MP0000762_abnormal_tongue_morphology1.26590539
64MP0004782_abnormal_surfactant_physiolog1.26195616
65MP0000538_abnormal_urinary_bladder1.22718764
66MP0000003_abnormal_adipose_tissue1.21306217
67MP0005381_digestive/alimentary_phenotyp1.19039360
68MP0010678_abnormal_skin_adnexa1.18946473
69MP0009840_abnormal_foam_cell1.18324189
70MP0005332_abnormal_amino_acid1.15191883
71MP0001663_abnormal_digestive_system1.15036790
72MP0002234_abnormal_pharynx_morphology1.14053656
73MP0000427_abnormal_hair_cycle1.11621268
74MP0010030_abnormal_orbit_morphology1.07931516
75MP0000470_abnormal_stomach_morphology1.07462545
76MP0004133_heterotaxia1.05040206
77MP0002736_abnormal_nociception_after1.01935368
78MP0004947_skin_inflammation1.01707896
79MP0002136_abnormal_kidney_physiology1.01414565
80MP0005666_abnormal_adipose_tissue0.99409434
81MP0003453_abnormal_keratinocyte_physiol0.99380904
82MP0005501_abnormal_skin_physiology0.97534903
83MP0003315_abnormal_perineum_morphology0.96153973
84MP0000685_abnormal_immune_system0.95389206
85MP0002078_abnormal_glucose_homeostasis0.94764438
86MP0003718_maternal_effect0.93941593
87MP0003878_abnormal_ear_physiology0.93768839
88MP0005377_hearing/vestibular/ear_phenot0.93768839
89MP0002166_altered_tumor_susceptibility0.92402858
90MP0005058_abnormal_lysosome_morphology0.91984842
91MP0001216_abnormal_epidermal_layer0.91982133
92MP0009931_abnormal_skin_appearance0.90707575
93MP0002928_abnormal_bile_duct0.86221312
94MP0003941_abnormal_skin_development0.86043624
95MP0010329_abnormal_lipoprotein_level0.85843998
96MP0009379_abnormal_foot_pigmentation0.85429756
97MP0002060_abnormal_skin_morphology0.83692418
98MP0003119_abnormal_digestive_system0.83558471
99MP0005409_darkened_coat_color0.82823535
100MP0000609_abnormal_liver_physiology0.82714286
101MP0003959_abnormal_lean_body0.82041522
102MP0004957_abnormal_blastocyst_morpholog0.81823741
103MP0003936_abnormal_reproductive_system0.80738246
104MP0002876_abnormal_thyroid_physiology0.76909543
105MP0005319_abnormal_enzyme/_coenzyme0.76894823
106MP0003191_abnormal_cellular_cholesterol0.76640557
107MP0002277_abnormal_respiratory_mucosa0.76548483
108MP0000681_abnormal_thyroid_gland0.75300474
109MP0003186_abnormal_redox_activity0.74464829
110MP0001764_abnormal_homeostasis0.74226098
111MP0000367_abnormal_coat/_hair0.74211801
112MP0005645_abnormal_hypothalamus_physiol0.72947606
113MP0005451_abnormal_body_composition0.72664049
114MP0005367_renal/urinary_system_phenotyp0.72622669
115MP0000516_abnormal_urinary_system0.72622669
116MP0005408_hypopigmentation0.72565272
117MP0005670_abnormal_white_adipose0.71852024
118MP0008872_abnormal_physiological_respon0.71677930
119MP0001905_abnormal_dopamine_level0.70688386
120MP0001845_abnormal_inflammatory_respons0.70520611
121MP0003953_abnormal_hormone_level0.70439345
122MP0000467_abnormal_esophagus_morphology0.70040984
123MP0003638_abnormal_response/metabolism_0.69884159
124MP0001853_heart_inflammation0.68721057
125MP0002653_abnormal_ependyma_morphology0.68074320
126MP0003786_premature_aging0.67863031
127MP0003763_abnormal_thymus_physiology0.66356921
128MP0002160_abnormal_reproductive_system0.66084227
129MP0002118_abnormal_lipid_homeostasis0.66040851
130MP0001881_abnormal_mammary_gland0.65340233
131MP0003566_abnormal_cell_adhesion0.64475968
132MP0005375_adipose_tissue_phenotype0.64380016
133MP0001346_abnormal_lacrimal_gland0.64252422
134MP0000858_altered_metastatic_potential0.63302104
135MP0005023_abnormal_wound_healing0.63198167
136MP0003879_abnormal_hair_cell0.63042847
137MP0000647_abnormal_sebaceous_gland0.62986125
138MP0005165_increased_susceptibility_to0.58187660
139MP0005646_abnormal_pituitary_gland0.57351279
140MP0008260_abnormal_autophagy0.57282587

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.44811155
2Late onset (HP:0003584)4.23144092
3Hypoglycemic seizures (HP:0002173)4.17412333
4Hyperactive renin-angiotensin system (HP:0000841)4.07317318
5Symptomatic seizures (HP:0011145)4.07055412
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.01288521
7Onycholysis (HP:0001806)3.96504987
8Cutaneous melanoma (HP:0012056)3.95557466
9Gout (HP:0001997)3.83730288
10Hyperinsulinemic hypoglycemia (HP:0000825)3.76540114
11Right ventricular cardiomyopathy (HP:0011663)3.54251120
12Ketoacidosis (HP:0001993)3.54143880
13Abnormality of chloride homeostasis (HP:0011422)3.52662265
14Pili torti (HP:0003777)3.42955885
15Vascular calcification (HP:0004934)3.41154478
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35927555
17Hyperglycemia (HP:0003074)3.16588344
18Sparse eyelashes (HP:0000653)3.09136652
19Hyperparathyroidism (HP:0000843)3.05809726
20Vacuolated lymphocytes (HP:0001922)3.03606508
21Amelogenesis imperfecta (HP:0000705)3.03067432
22Abnormality of endocrine pancreas physiology (HP:0012093)3.00684341
23Abnormality of the pancreatic islet cells (HP:0006476)3.00684341
24Lip pit (HP:0100267)2.99205425
25Hyperthyroidism (HP:0000836)2.96985102
26Abnormality of calcium-phosphate metabolism (HP:0100530)2.90079305
27Hypokinesia (HP:0002375)2.89709674
28Alopecia of scalp (HP:0002293)2.86870486
29Interstitial pulmonary disease (HP:0006530)2.80518184
30Generalized aminoaciduria (HP:0002909)2.75749021
31Milia (HP:0001056)2.70245868
32Villous atrophy (HP:0011473)2.69793169
33Abnormality of small intestinal villus morphology (HP:0011472)2.69793169
34Palmoplantar hyperkeratosis (HP:0000972)2.67262184
35Cardiovascular calcification (HP:0011915)2.63410702
36Decreased circulating renin level (HP:0003351)2.62579516
37Hyperphosphatemia (HP:0002905)2.61615953
38Abnormality of renin-angiotensin system (HP:0000847)2.61583428
39Congenital ichthyosiform erythroderma (HP:0007431)2.59187623
40Abnormal pancreas size (HP:0012094)2.56299052
41Micronodular cirrhosis (HP:0001413)2.56274316
42Septate vagina (HP:0001153)2.54169605
43Dysostosis multiplex (HP:0000943)2.53724434
44Insulin resistance (HP:0000855)2.50531619
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49171616
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49171616
47Ketosis (HP:0001946)2.47453669
48Nail dystrophy (HP:0008404)2.46520542
49Microretrognathia (HP:0000308)2.45698423
50Abnormality of nail color (HP:0100643)2.42078173
51* Abdominal distention (HP:0003270)2.41868989
52Mucopolysacchariduria (HP:0008155)2.41567644
53Urinary glycosaminoglycan excretion (HP:0003541)2.41567644
54Short nail (HP:0001799)2.41442371
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40769745
56Chronic bronchitis (HP:0004469)2.40284535
57Exocrine pancreatic insufficiency (HP:0001738)2.39558208
58Abnormality of the dental root (HP:0006486)2.38674193
59Taurodontia (HP:0000679)2.38674193
60Abnormality of permanent molar morphology (HP:0011071)2.38674193
61Palmar hyperkeratosis (HP:0010765)2.36934258
62Growth hormone excess (HP:0000845)2.34782930
63Hypokalemia (HP:0002900)2.34684946
64Abnormal biliary tract morphology (HP:0012440)2.34426098
65Methylmalonic aciduria (HP:0012120)2.32321320
66Abnormality of the intrinsic pathway (HP:0010989)2.32048381
67Fragile nails (HP:0001808)2.31176346
68Abnormality of the gastric mucosa (HP:0004295)2.31132967
69Abnormality of purine metabolism (HP:0004352)2.29629910
70Hypoplasia of the uterus (HP:0000013)2.28096437
71Abnormal protein glycosylation (HP:0012346)2.27840519
72Abnormal glycosylation (HP:0012345)2.27840519
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27840519
74Abnormal protein N-linked glycosylation (HP:0012347)2.27840519
75Abnormal hair laboratory examination (HP:0003328)2.27217092
76Hyperaldosteronism (HP:0000859)2.25209255
77Hypotension (HP:0002615)2.23938062
78Unilateral renal agenesis (HP:0000122)2.23718396
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23063980
80Dicarboxylic aciduria (HP:0003215)2.23063980
81Trismus (HP:0000211)2.22618895
82J-shaped sella turcica (HP:0002680)2.22565295
83Hypoplasia of dental enamel (HP:0006297)2.22454572
84Proximal tubulopathy (HP:0000114)2.22224955
85Renal salt wasting (HP:0000127)2.20904177
86Hypotrichosis (HP:0001006)2.20413630
87Dehydration (HP:0001944)2.19308026
88Woolly hair (HP:0002224)2.18320149
89Type I transferrin isoform profile (HP:0003642)2.18089223
90Distal lower limb muscle weakness (HP:0009053)2.17547517
91Palpitations (HP:0001962)2.16724297
92Hyperammonemia (HP:0001987)2.15632423
93Aplasia/hypoplasia of the uterus (HP:0008684)2.15153774
94Conjugated hyperbilirubinemia (HP:0002908)2.15138150
95Adrenal overactivity (HP:0002717)2.14993969
96Spinal cord compression (HP:0002176)2.13610209
97Goiter (HP:0000853)2.13091733
98Abnormality of vitamin B metabolism (HP:0004340)2.11840351
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11582853
100Abnormality of polysaccharide metabolism (HP:0011012)2.11582853
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11582853
10211 pairs of ribs (HP:0000878)2.11394318
103Plantar hyperkeratosis (HP:0007556)2.09945196
104Abnormality of cells of the erythroid lineage (HP:0012130)2.09467586
105Abnormality of vitamin metabolism (HP:0100508)2.09300923
106Abnormal number of erythroid precursors (HP:0012131)2.07932477
107Retinal atrophy (HP:0001105)2.07206509
108Increased purine levels (HP:0004368)2.07199625
109Hyperuricemia (HP:0002149)2.07199625
110Abnormality of molar morphology (HP:0011070)2.05523829
111Abnormality of molar (HP:0011077)2.05523829
112Testicular atrophy (HP:0000029)2.05231847
113Hypercortisolism (HP:0001578)2.04778682
114Meningioma (HP:0002858)2.04502546
115Pancreatic islet-cell hyperplasia (HP:0004510)2.04412728
116Thrombocytosis (HP:0001894)2.04266680
117Ileus (HP:0002595)2.04165260
118Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03720893
119Insulin-resistant diabetes mellitus (HP:0000831)2.03416915
120Abnormality of the dental pulp (HP:0006479)2.03385181
121Large for gestational age (HP:0001520)2.03329127
122Abnormality of the distal phalanges of the toes (HP:0010182)2.03079393
123Pterygium (HP:0001059)2.02755345
124Posterior subcapsular cataract (HP:0007787)2.00814109
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98774633
126Malnutrition (HP:0004395)1.98011385
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97844406
128Popliteal pterygium (HP:0009756)1.96410817
129Focal segmental glomerulosclerosis (HP:0000097)1.96023777
130Progressive neurologic deterioration (HP:0002344)1.95309406
131Biliary tract neoplasm (HP:0100574)1.93955294
132Concave nail (HP:0001598)1.92508433
133Abnormality of renal excretion (HP:0011036)1.91526960
134Glomerulosclerosis (HP:0000096)1.90886161
135Fat malabsorption (HP:0002630)1.90511234
136Acanthosis nigricans (HP:0000956)1.90435666
137Pustule (HP:0200039)1.90144089
138Conjunctival hamartoma (HP:0100780)1.88690483
139Esophageal varix (HP:0002040)1.87142857
140Abnormal blistering of the skin (HP:0008066)1.86364740
141Abnormality of potassium homeostasis (HP:0011042)1.86126140
142Abnormality of urine glucose concentration (HP:0011016)1.86041408
143Glycosuria (HP:0003076)1.86041408
144Tongue fasciculations (HP:0001308)1.85641579
145Abnormal respiratory motile cilium physiology (HP:0012261)1.85475950
146Flat acetabular roof (HP:0003180)1.85065542
147Methylmalonic acidemia (HP:0002912)1.84898263
148Rectal prolapse (HP:0002035)1.84494915
149Death in infancy (HP:0001522)1.84416030
150Abnormality of the vitamin B12 metabolism (HP:0004341)1.84177725
151Abnormality of fatty-acid metabolism (HP:0004359)1.82968624
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80591110
153Cardiomegaly (HP:0001640)1.80570370
154Hyponatremia (HP:0002902)1.78900221
155Lethargy (HP:0001254)1.77243113
156Rhinitis (HP:0012384)1.76668540
157Selective tooth agenesis (HP:0001592)1.76478266
158Truncus arteriosus (HP:0001660)1.75396518
159Prolonged neonatal jaundice (HP:0006579)1.74677073
160Hyperglycinemia (HP:0002154)1.74557500
161Ridged nail (HP:0001807)1.74273819
162Diminished movement (HP:0002374)1.74246798
163Abnormal respiratory epithelium morphology (HP:0012253)1.72389798
164Abnormal respiratory motile cilium morphology (HP:0005938)1.72389798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.36710120
2EPHA24.57579146
3WNK33.71785368
4ERN13.09772259
5FRK2.96412412
6PIK3CG2.70495058
7MAP2K22.52032202
8BCKDK2.49687438
9MST42.47246401
10TAOK32.25444308
11VRK22.12697700
12WNK42.11893332
13SMG12.03739042
14MAPKAPK32.02370164
15PASK2.01728408
16INSRR1.98284340
17MAP3K21.97006223
18FLT31.95634165
19RPS6KB21.86907941
20PTK61.85973666
21MST1R1.67585756
22TESK11.49608505
23ARAF1.47452134
24RIPK11.41932192
25SCYL21.41529769
26MAP3K31.38537636
27DYRK1B1.37857659
28PAK41.35810717
29PRKG21.35210270
30PTK21.32276032
31LMTK21.29535538
32DYRK31.28595478
33FER1.24346085
34STK161.23737088
35TRIB31.22852195
36PRKCI1.22176230
37MYLK1.20862444
38PBK1.20264053
39LRRK21.18562998
40FGFR41.17739853
41HIPK21.17376070
42EEF2K1.16167542
43IRAK31.15896379
44DAPK11.10358418
45NME11.09530911
46LIMK11.05076488
47EIF2AK11.03777448
48ZAP701.00677016
49EPHA30.99365397
50MAP3K10.95339469
51MAP2K60.94709465
52EPHB10.93355660
53EIF2AK30.92969382
54PIM20.91843786
55NLK0.89198203
56NME20.88222429
57MAP3K90.88076992
58ABL20.87022026
59MUSK0.86414000
60SIK10.84849734
61TGFBR10.84346233
62STK390.80046372
63CAMK2G0.78173911
64PKN20.77235776
65BTK0.76287670
66TBK10.72678853
67MET0.72656960
68CHUK0.70253336
69MATK0.68469203
70BRSK20.67699668
71MAP3K110.67510817
72BMX0.66693263
73OXSR10.64261331
74RPS6KA40.63020397
75JAK30.60865572
76MAP2K10.60312290
77TYK20.58339717
78ACVR1B0.56858866
79AKT30.55912498
80CAMK2D0.55218553
81PHKG20.55013448
82PHKG10.55013448
83LATS10.53877837
84MAP2K30.53269565
85STK100.52770551
86STK240.51381810
87MAP3K130.50742741
88AURKA0.50146982
89MAP3K80.48757490
90PRKD20.48639726
91KDR0.48038840
92EPHB20.47013111
93FGFR20.46665913
94CAMK2B0.46600125
95MAP3K120.45944510
96STK380.45744354
97CSNK1G30.44895112
98AURKB0.44062233
99MAP3K100.43512307
100BUB10.41728741
101IRAK20.41436412
102IKBKB0.39513403
103TEC0.39490264
104TGFBR20.38763910
105NTRK10.38734412
106IKBKE0.38626146
107CSK0.38307551
108MAPKAPK20.38178800
109IRAK10.37193191
110PDPK10.36746518
111NEK60.36202866
112CSNK1A10.35913403
113MAP4K10.35768816
114RPS6KA20.35669605
115GRK10.35536008
116CDK80.35458983
117KSR20.35295469
118STK38L0.34567140
119ERBB20.34497375
120MAPK110.33278652
121AKT20.31521397
122NUAK10.31219029
123CDK90.30011530
124JAK20.29800941
125MTOR0.29305479
126GRK60.28793108
127CDK70.27459930
128TAOK10.27346956
129DAPK30.26664224
130CSNK1G10.25741341
131CAMKK20.24667996
132PIK3CA0.23929874
133CSF1R0.23414055
134RPS6KA10.22925878
135MAP3K70.22659492
136ILK0.22604464
137PRKCE0.21721840
138MAP2K70.21609753
139PLK10.21606973
140TESK20.20746299
141VRK10.19747864
142PAK30.19248749
143CDK60.19017741

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.66381947
2Protein export_Homo sapiens_hsa030603.81980521
3Sulfur metabolism_Homo sapiens_hsa009203.64363819
4Folate biosynthesis_Homo sapiens_hsa007903.02337808
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.62723600
6Fat digestion and absorption_Homo sapiens_hsa049752.52001526
7Fatty acid elongation_Homo sapiens_hsa000622.28803878
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16858872
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08619085
10Other glycan degradation_Homo sapiens_hsa005111.92902894
11N-Glycan biosynthesis_Homo sapiens_hsa005101.91435981
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85102387
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83439295
14Ribosome_Homo sapiens_hsa030101.78324535
15Selenocompound metabolism_Homo sapiens_hsa004501.73553604
16Oxidative phosphorylation_Homo sapiens_hsa001901.72033400
17Histidine metabolism_Homo sapiens_hsa003401.65629479
18Galactose metabolism_Homo sapiens_hsa000521.61907431
19Protein digestion and absorption_Homo sapiens_hsa049741.58880879
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58249898
21Caffeine metabolism_Homo sapiens_hsa002321.49685143
22Mineral absorption_Homo sapiens_hsa049781.44803522
23Glutathione metabolism_Homo sapiens_hsa004801.44216688
24Pancreatic secretion_Homo sapiens_hsa049721.44140133
25Base excision repair_Homo sapiens_hsa034101.39754612
26Vibrio cholerae infection_Homo sapiens_hsa051101.35514459
27Renin-angiotensin system_Homo sapiens_hsa046141.33885152
28Tryptophan metabolism_Homo sapiens_hsa003801.33419241
29Fructose and mannose metabolism_Homo sapiens_hsa000511.31215960
30Fatty acid degradation_Homo sapiens_hsa000711.30980483
31Sulfur relay system_Homo sapiens_hsa041221.25261062
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24925641
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23773446
34Vitamin digestion and absorption_Homo sapiens_hsa049771.21767249
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20467417
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19177056
37Collecting duct acid secretion_Homo sapiens_hsa049661.19142977
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.18193345
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14282354
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13777007
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.11195837
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.10154398
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09224903
44Thyroid cancer_Homo sapiens_hsa052161.08423891
45Huntingtons disease_Homo sapiens_hsa050161.07672854
46Linoleic acid metabolism_Homo sapiens_hsa005911.07331055
47Antigen processing and presentation_Homo sapiens_hsa046121.06487013
48Arginine biosynthesis_Homo sapiens_hsa002201.01185880
49Starch and sucrose metabolism_Homo sapiens_hsa005000.98156382
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96724191
51Bladder cancer_Homo sapiens_hsa052190.94138807
52Pentose phosphate pathway_Homo sapiens_hsa000300.92157336
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91871808
54Parkinsons disease_Homo sapiens_hsa050120.91627903
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90704967
56ABC transporters_Homo sapiens_hsa020100.90550526
57Alzheimers disease_Homo sapiens_hsa050100.89727386
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.89495543
59Thyroid hormone synthesis_Homo sapiens_hsa049180.89426525
60Arachidonic acid metabolism_Homo sapiens_hsa005900.88469296
61Chemical carcinogenesis_Homo sapiens_hsa052040.86619941
62Lysosome_Homo sapiens_hsa041420.85911460
63Legionellosis_Homo sapiens_hsa051340.74459040
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72064272
65Arginine and proline metabolism_Homo sapiens_hsa003300.71288041
66beta-Alanine metabolism_Homo sapiens_hsa004100.70191687
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69668039
68Regulation of autophagy_Homo sapiens_hsa041400.69130914
69Pyruvate metabolism_Homo sapiens_hsa006200.68762343
70Fatty acid metabolism_Homo sapiens_hsa012120.67235198
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65876864
72Bile secretion_Homo sapiens_hsa049760.65485327
73Steroid biosynthesis_Homo sapiens_hsa001000.65237292
74Tight junction_Homo sapiens_hsa045300.64801476
75Peroxisome_Homo sapiens_hsa041460.64433383
76DNA replication_Homo sapiens_hsa030300.61960079
77Insulin secretion_Homo sapiens_hsa049110.61768909
78Glycerolipid metabolism_Homo sapiens_hsa005610.60637664
79Pyrimidine metabolism_Homo sapiens_hsa002400.59849830
80Proteasome_Homo sapiens_hsa030500.57416288
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57403353
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55511855
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55224621
84Hepatitis C_Homo sapiens_hsa051600.51245920
85Phenylalanine metabolism_Homo sapiens_hsa003600.50680040
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.50395919
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49363400
88Sphingolipid metabolism_Homo sapiens_hsa006000.48133542
89Metabolic pathways_Homo sapiens_hsa011000.47896255
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47049783
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46098457
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46008436
93Carbon metabolism_Homo sapiens_hsa012000.45876284
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44826021
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.44680123
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.43264288
97Synaptic vesicle cycle_Homo sapiens_hsa047210.42822101
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40610220
99Endocytosis_Homo sapiens_hsa041440.39217983
100Fatty acid biosynthesis_Homo sapiens_hsa000610.38281297
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37592543
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37389016
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37110591
104Acute myeloid leukemia_Homo sapiens_hsa052210.35830462
105Shigellosis_Homo sapiens_hsa051310.35112921
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34626356
107Propanoate metabolism_Homo sapiens_hsa006400.32617192
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32258653
109Mismatch repair_Homo sapiens_hsa034300.31761206
110Circadian rhythm_Homo sapiens_hsa047100.31436084
111Ether lipid metabolism_Homo sapiens_hsa005650.31431622
112Insulin resistance_Homo sapiens_hsa049310.30930700
113Glucagon signaling pathway_Homo sapiens_hsa049220.30433597
114p53 signaling pathway_Homo sapiens_hsa041150.30392905
115Biosynthesis of amino acids_Homo sapiens_hsa012300.29540290
116Prolactin signaling pathway_Homo sapiens_hsa049170.28718401
117Retinol metabolism_Homo sapiens_hsa008300.27308752
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26736322
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.24076210
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24035533
121Small cell lung cancer_Homo sapiens_hsa052220.23837191
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22650365
123RNA polymerase_Homo sapiens_hsa030200.22566981
124Influenza A_Homo sapiens_hsa051640.22178300
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20535648
126Toxoplasmosis_Homo sapiens_hsa051450.19970649
127Tyrosine metabolism_Homo sapiens_hsa003500.19145221
128Adherens junction_Homo sapiens_hsa045200.17878573

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