SPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.28363561
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.00778303
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.00778303
4regulation of gamma-delta T cell differentiation (GO:0045586)5.15231389
5antigen processing and presentation of endogenous antigen (GO:0019883)5.07191112
6negative regulation of cell killing (GO:0031342)4.88847185
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88847185
8positive thymic T cell selection (GO:0045059)4.85301180
9interferon-gamma production (GO:0032609)4.82872794
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.81934011
11regulation of gamma-delta T cell activation (GO:0046643)4.67756650
12leukocyte aggregation (GO:0070486)4.53228578
13response to interleukin-15 (GO:0070672)4.50951019
14T cell migration (GO:0072678)4.41555873
15* negative T cell selection (GO:0043383)4.37059868
16positive T cell selection (GO:0043368)4.33259515
17* negative thymic T cell selection (GO:0045060)4.14451718
18ribosomal small subunit assembly (GO:0000028)4.11716550
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.03301170
20tolerance induction (GO:0002507)3.92049970
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86969323
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86115819
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.86115819
24modulation by symbiont of host immune response (GO:0052553)3.86115819
25positive regulation by symbiont of host defense response (GO:0052509)3.86115819
26modulation by symbiont of host defense response (GO:0052031)3.86115819
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86115819
28regulation of B cell receptor signaling pathway (GO:0050855)3.84152064
29immunoglobulin mediated immune response (GO:0016064)3.80489870
30cellular response to interleukin-15 (GO:0071350)3.78997719
31positive regulation of B cell differentiation (GO:0045579)3.78578537
32* thymic T cell selection (GO:0045061)3.70271931
33regulation of isotype switching to IgG isotypes (GO:0048302)3.69254084
34* T cell selection (GO:0045058)3.61399362
35T cell receptor signaling pathway (GO:0050852)3.59159260
36T cell homeostasis (GO:0043029)3.56640880
37negative regulation of phagocytosis (GO:0050765)3.55445001
38viral transcription (GO:0019083)3.54415763
39regulation of B cell differentiation (GO:0045577)3.53887046
40response to peptidoglycan (GO:0032494)3.53131660
41regulation of granulocyte differentiation (GO:0030852)3.53106512
42response to muramyl dipeptide (GO:0032495)3.51598481
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48450864
44mast cell activation (GO:0045576)3.47919347
45positive regulation of isotype switching (GO:0045830)3.45380192
46detection of bacterium (GO:0016045)3.45133514
47antigen processing and presentation via MHC class Ib (GO:0002475)3.41800377
48translational termination (GO:0006415)3.39304140
49detection of other organism (GO:0098543)3.36436677
50neutrophil activation involved in immune response (GO:0002283)3.34894092
51activated T cell proliferation (GO:0050798)3.29571946
52antigen receptor-mediated signaling pathway (GO:0050851)3.28964850
53regulation of natural killer cell mediated immunity (GO:0002715)3.28006159
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28006159
55regulation of interleukin-2 biosynthetic process (GO:0045076)3.25576490
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24090801
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.23819711
58* T cell costimulation (GO:0031295)3.22670875
59definitive hemopoiesis (GO:0060216)3.18955073
60* lymphocyte costimulation (GO:0031294)3.18548009
61B cell mediated immunity (GO:0019724)3.16801923
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16239167
63megakaryocyte development (GO:0035855)3.16001847
64positive regulation of granulocyte differentiation (GO:0030854)3.14093612
65regulation of T cell receptor signaling pathway (GO:0050856)3.12173875
66regulation of alpha-beta T cell proliferation (GO:0046640)3.10130286
67positive regulation of interleukin-2 production (GO:0032743)3.09661870
68mast cell degranulation (GO:0043303)3.09461772
69mast cell activation involved in immune response (GO:0002279)3.09461772
70leukocyte degranulation (GO:0043299)3.09216901
71natural killer cell activation (GO:0030101)3.09107696
72regulation of mast cell degranulation (GO:0043304)3.07086612
73leukocyte cell-cell adhesion (GO:0007159)3.01723295
74B cell homeostasis (GO:0001782)3.00797223
75B cell receptor signaling pathway (GO:0050853)3.00541968
76DNA unwinding involved in DNA replication (GO:0006268)2.98851052
77myeloid cell activation involved in immune response (GO:0002275)2.98372914
78negative regulation of erythrocyte differentiation (GO:0045647)2.98147808
79lymphocyte homeostasis (GO:0002260)2.97561511
80translational elongation (GO:0006414)2.96834768
81positive regulation of B cell activation (GO:0050871)2.93217372
82regulation of regulatory T cell differentiation (GO:0045589)2.91887795
83macrophage activation involved in immune response (GO:0002281)2.91163534
84germinal center formation (GO:0002467)2.90410126
85regulation of mast cell activation (GO:0033003)2.90206541
86positive regulation of DNA recombination (GO:0045911)2.89070309
87positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.88539364
88T cell differentiation (GO:0030217)2.88181329
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87935943
90regulation of erythrocyte differentiation (GO:0045646)2.87678741
91respiratory burst (GO:0045730)2.87359495
92regulation of mast cell activation involved in immune response (GO:0033006)2.86367136
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.86280704
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.86280704
95interferon-gamma-mediated signaling pathway (GO:0060333)2.86087218
96regulation of isotype switching (GO:0045191)2.85917073
97positive regulation of B cell mediated immunity (GO:0002714)2.85699833
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.85699833
99defense response to protozoan (GO:0042832)2.85238470
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83725979
101response to host immune response (GO:0052572)2.83725979
102myeloid dendritic cell activation (GO:0001773)2.83643299
103* negative regulation of lymphocyte mediated immunity (GO:0002707)2.83483780
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81848647
105response to type I interferon (GO:0034340)2.79973799
106positive regulation of mast cell activation (GO:0033005)2.79351831
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78335342
108hepatocyte apoptotic process (GO:0097284)2.77411046
109type I interferon signaling pathway (GO:0060337)2.76239156
110cellular response to type I interferon (GO:0071357)2.76239156
111alpha-beta T cell activation (GO:0046631)2.76059213
112T cell proliferation (GO:0042098)2.75490249
113regulation of alpha-beta T cell activation (GO:0046634)2.75335874
114ribosomal small subunit biogenesis (GO:0042274)2.74911316
115protein targeting to ER (GO:0045047)2.74765155
116regulation of response to interferon-gamma (GO:0060330)2.74594205
117cotranslational protein targeting to membrane (GO:0006613)2.74085679
118negative regulation of interleukin-12 production (GO:0032695)2.73499846
119neutrophil activation (GO:0042119)2.73352482
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72560351
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.72203323
122positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.71522295
123positive regulation of alpha-beta T cell differentiation (GO:0046638)2.70701181
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70056432
125regulation of B cell apoptotic process (GO:0002902)2.70052328
126tyrosine phosphorylation of STAT protein (GO:0007260)2.69812259
127regulation of leukocyte mediated cytotoxicity (GO:0001910)2.69768498
128cellular extravasation (GO:0045123)2.69168621
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68699895
130NIK/NF-kappaB signaling (GO:0038061)2.68684661
131regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.68643501
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68230799
133positive regulation of alpha-beta T cell activation (GO:0046635)2.67406525
134CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.67266807
135regulation of B cell mediated immunity (GO:0002712)2.66051874
136leukocyte homeostasis (GO:0001776)2.65673637
137natural killer cell differentiation (GO:0001779)2.65059017
138T cell activation (GO:0042110)2.64855394
139Peyers patch development (GO:0048541)2.64124101
140mucosal-associated lymphoid tissue development (GO:0048537)2.64124101
141viral life cycle (GO:0019058)2.63048571
142establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62618314
143protein localization to kinetochore (GO:0034501)2.62156814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.21140244
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54739622
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.21636614
4MYC_22102868_ChIP-Seq_BL_Human3.54228409
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10939491
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.08774485
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.96527512
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92410076
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.88204682
10SCL_19346495_ChIP-Seq_HPC-7_Human2.78702712
11* VDR_21846776_ChIP-Seq_THP-1_Human2.68389706
12* MYB_26560356_Chip-Seq_TH2_Human2.61874828
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57659434
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51784096
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50692284
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.49774547
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46630395
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46160782
19MAF_26560356_Chip-Seq_TH1_Human2.44071306
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42775052
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39164314
22RUNX_20019798_ChIP-Seq_JUKART_Human2.38069882
23GATA1_22025678_ChIP-Seq_K562_Human2.37794482
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33328929
25* MYB_26560356_Chip-Seq_TH1_Human2.30112706
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27533974
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.25401657
28* UTX_26944678_Chip-Seq_JUKART_Human2.21928288
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14999879
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14740713
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06205993
32* SPI1_23547873_ChIP-Seq_NB4_Human2.04878278
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04522399
34IRF8_21731497_ChIP-ChIP_J774_Mouse2.00791196
35TCF7_22412390_ChIP-Seq_EML_Mouse1.97842943
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.97360712
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95338619
38* VDR_24763502_ChIP-Seq_THP-1_Human1.86649039
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83088811
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83008675
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78692838
42CIITA_25753668_ChIP-Seq_RAJI_Human1.78511859
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78190790
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77016746
45* GATA1_19941826_ChIP-Seq_K562_Human1.73162003
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.72732990
47* MAF_26560356_Chip-Seq_TH2_Human1.69099377
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.68384120
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66858820
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.63352182
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62891454
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52562502
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50634004
54VDR_23849224_ChIP-Seq_CD4+_Human1.49587805
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48885584
56GATA3_27048872_Chip-Seq_THYMUS_Human1.48730683
57FOXP3_21729870_ChIP-Seq_TREG_Human1.48568984
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47716507
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45933283
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43596164
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41953355
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39365086
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37600818
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.35239424
65SPI1_23127762_ChIP-Seq_K562_Human1.32240914
66VDR_24787735_ChIP-Seq_THP-1_Human1.31732073
67* KDM2B_26808549_Chip-Seq_DND41_Human1.31686756
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31148127
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30654214
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30642042
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28268772
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28018578
73XRN2_22483619_ChIP-Seq_HELA_Human1.24266003
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22906752
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22634650
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.20527673
77* GATA2_19941826_ChIP-Seq_K562_Human1.20090945
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18637361
79PU_27001747_Chip-Seq_BMDM_Mouse1.12675675
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11569405
81ELK1_19687146_ChIP-ChIP_HELA_Human1.09184730
82BCL6_27268052_Chip-Seq_Bcells_Human1.08988350
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08496208
84* ELF1_20517297_ChIP-Seq_JURKAT_Human1.07564989
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07017305
86* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05519153
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04620023
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03770872
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03760999
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.03131494
91BCOR_27268052_Chip-Seq_Bcells_Human1.00051318
92GABP_17652178_ChIP-ChIP_JURKAT_Human0.99911607
93KDM5A_27292631_Chip-Seq_BREAST_Human0.99337820
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99175784
95* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99029083
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98571350
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.97717920
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97525269
99GATA3_26560356_Chip-Seq_TH2_Human0.97270500
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94918992
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94446508
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.93831461
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93604860
104SPI1_20517297_ChIP-Seq_HL60_Human0.92599070
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92127372
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91916214
107* NCOR1_26117541_ChIP-Seq_K562_Human0.89453920
108P300_27268052_Chip-Seq_Bcells_Human0.87785075
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87436099
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86344750
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85519325
112PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85287312
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85255896
114NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83922960
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83236579
116* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82843709
117GABP_19822575_ChIP-Seq_HepG2_Human0.82634222
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82337846
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.81557809
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80583162
121TFEB_21752829_ChIP-Seq_HELA_Human0.80184721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.06047176
2MP0005671_abnormal_response_to3.56504547
3MP0002396_abnormal_hematopoietic_system3.42491361
4MP0001835_abnormal_antigen_presentation3.20056858
5MP0000685_abnormal_immune_system3.08959556
6MP0001800_abnormal_humoral_immune2.88115133
7MP0002398_abnormal_bone_marrow2.77799925
8MP0002420_abnormal_adaptive_immunity2.60534614
9MP0003436_decreased_susceptibility_to2.57721153
10MP0001819_abnormal_immune_cell2.56785333
11MP0004808_abnormal_hematopoietic_stem2.54459529
12MP0001790_abnormal_immune_system2.52529506
13MP0005387_immune_system_phenotype2.52529506
14MP0005000_abnormal_immune_tolerance2.51873106
15MP0002723_abnormal_immune_serum2.50628545
16MP0002166_altered_tumor_susceptibility2.47926163
17MP0009785_altered_susceptibility_to2.45115735
18MP0002452_abnormal_antigen_presenting2.43688303
19MP0009333_abnormal_splenocyte_physiolog2.43131927
20MP0003303_peritoneal_inflammation2.43058372
21MP0001873_stomach_inflammation2.40827698
22MP0000703_abnormal_thymus_morphology2.37236626
23MP0003300_gastrointestinal_ulcer2.36890409
24* MP0005025_abnormal_response_to2.33610451
25MP0000716_abnormal_immune_system2.32066870
26MP0005464_abnormal_platelet_physiology2.31321780
27MP0002722_abnormal_immune_system2.29336864
28MP0002405_respiratory_system_inflammati2.23438137
29MP0000689_abnormal_spleen_morphology2.22292255
30MP0003866_abnormal_defecation2.10639374
31MP0002006_tumorigenesis2.10145795
32MP0010155_abnormal_intestine_physiology2.07817396
33MP0000465_gastrointestinal_hemorrhage2.04285857
34MP0002429_abnormal_blood_cell2.02501822
35MP0002419_abnormal_innate_immunity1.99515072
36MP0005397_hematopoietic_system_phenotyp1.98257083
37MP0001545_abnormal_hematopoietic_system1.98257083
38MP0008057_abnormal_DNA_replication1.92013590
39MP0000490_abnormal_crypts_of1.82903133
40MP0006082_CNS_inflammation1.82177360
41MP0010094_abnormal_chromosome_stability1.78353592
42MP0002148_abnormal_hypersensitivity_rea1.78097161
43MP0003724_increased_susceptibility_to1.77939161
44MP0009278_abnormal_bone_marrow1.69847195
45MP0003693_abnormal_embryo_hatching1.69431924
46MP0004947_skin_inflammation1.61146156
47MP0001845_abnormal_inflammatory_respons1.61130374
48MP0001853_heart_inflammation1.60949140
49MP0003077_abnormal_cell_cycle1.52945281
50MP0005174_abnormal_tail_pigmentation1.52631912
51MP0000858_altered_metastatic_potential1.46339473
52MP0010352_gastrointestinal_tract_polyps1.44622591
53MP0003111_abnormal_nucleus_morphology1.43731366
54MP0002933_joint_inflammation1.36589190
55* MP0002019_abnormal_tumor_incidence1.30102280
56MP0004957_abnormal_blastocyst_morpholog1.28918867
57MP0010307_abnormal_tumor_latency1.25165112
58MP0005075_abnormal_melanosome_morpholog1.23817573
59MP0005310_abnormal_salivary_gland1.22585079
60MP0003448_altered_tumor_morphology1.21352120
61MP0005451_abnormal_body_composition1.20269321
62MP0004510_myositis1.15263264
63MP0008469_abnormal_protein_level1.08338235
64MP0001533_abnormal_skeleton_physiology1.06919608
65MP0008007_abnormal_cellular_replicative1.00675335
66MP0005645_abnormal_hypothalamus_physiol0.99180076
67MP0001851_eye_inflammation0.99117843
68MP0008058_abnormal_DNA_repair0.98375289
69MP0002132_abnormal_respiratory_system0.97211468
70MP0005076_abnormal_cell_differentiation0.96159661
71MP0004147_increased_porphyrin_level0.94925928
72MP0002138_abnormal_hepatobiliary_system0.91776256
73MP0002009_preneoplasia0.88324152
74MP0000313_abnormal_cell_death0.86472422
75MP0002095_abnormal_skin_pigmentation0.86363651
76MP0000350_abnormal_cell_proliferation0.82091424
77MP0006054_spinal_hemorrhage0.81336815
78MP0002877_abnormal_melanocyte_morpholog0.78556521
79MP0001663_abnormal_digestive_system0.77378208
80MP0008961_abnormal_basal_metabolism0.71825197
81MP0003172_abnormal_lysosome_physiology0.71200760
82MP0000569_abnormal_digit_pigmentation0.71030890
83MP0005023_abnormal_wound_healing0.69365887
84MP0008995_early_reproductive_senescence0.67306542
85MP0000477_abnormal_intestine_morphology0.67282608
86MP0008260_abnormal_autophagy0.66926245
87MP0009763_increased_sensitivity_to0.66625621
88MP0000015_abnormal_ear_pigmentation0.66496749
89MP0005058_abnormal_lysosome_morphology0.65946958
90MP0009115_abnormal_fat_cell0.65391055
91MP0001730_embryonic_growth_arrest0.65114407
92MP0003566_abnormal_cell_adhesion0.63568370
93MP0002998_abnormal_bone_remodeling0.63469923
94MP0003183_abnormal_peptide_metabolism0.62797544
95MP0003943_abnormal_hepatobiliary_system0.61614913
96MP0008873_increased_physiological_sensi0.60870073
97MP0000343_altered_response_to0.60436320
98MP0003191_abnormal_cellular_cholesterol0.59456553
99MP0002693_abnormal_pancreas_physiology0.59329527
100MP0003656_abnormal_erythrocyte_physiolo0.59275755
101MP0003045_fibrosis0.59028538
102MP0002086_abnormal_extraembryonic_tissu0.58291225
103MP0004381_abnormal_hair_follicle0.57221026
104MP0001986_abnormal_taste_sensitivity0.56407919
105MP0000609_abnormal_liver_physiology0.55934168
106MP0003806_abnormal_nucleotide_metabolis0.55478036
107MP0004130_abnormal_muscle_cell0.55059451
108MP0009765_abnormal_xenobiotic_induced0.54220742
109MP0000371_diluted_coat_color0.53980615
110MP0005647_abnormal_sex_gland0.53846427
111MP0006036_abnormal_mitochondrial_physio0.53638849
112MP0004883_abnormal_blood_vessel0.52732626
113MP0000372_irregular_coat_pigmentation0.52230092
114MP0003795_abnormal_bone_structure0.52014126
115MP0002080_prenatal_lethality0.51997859
116MP0008877_abnormal_DNA_methylation0.51237961
117MP0005083_abnormal_biliary_tract0.49594262
118MP0009764_decreased_sensitivity_to0.49070911
119MP0003786_premature_aging0.48213386
120MP0005621_abnormal_cell_physiology0.47875142
121MP0003828_pulmonary_edema0.46088671

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.90151495
2T lymphocytopenia (HP:0005403)4.89519346
3Abnormality of T cell number (HP:0011839)4.62905555
4Chronic otitis media (HP:0000389)4.36001276
5Recurrent viral infections (HP:0004429)4.34301637
6Recurrent fungal infections (HP:0002841)4.31201247
7Myositis (HP:0100614)4.27581171
8Abnormality of T cells (HP:0002843)4.24708922
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.14751759
10Elevated erythrocyte sedimentation rate (HP:0003565)4.09022164
11Thrombocytosis (HP:0001894)4.05956354
12Panhypogammaglobulinemia (HP:0003139)4.05638402
13Nasal polyposis (HP:0100582)3.96014025
14Recurrent bronchitis (HP:0002837)3.93870463
15Eczematoid dermatitis (HP:0000976)3.85982795
16Abnormality of T cell physiology (HP:0011840)3.57694173
17Prolonged bleeding time (HP:0003010)3.54980794
18Abnormality of the fingertips (HP:0001211)3.51642160
19B lymphocytopenia (HP:0010976)3.51221404
20Abnormality of B cell number (HP:0010975)3.51221404
21Meningitis (HP:0001287)3.42686111
22Recurrent abscess formation (HP:0002722)3.41662950
23Recurrent cutaneous fungal infections (HP:0011370)3.39644397
24Chronic mucocutaneous candidiasis (HP:0002728)3.39644397
25Abnormality of the nasal mucosa (HP:0000433)3.37246508
26Petechiae (HP:0000967)3.32205800
27Severe combined immunodeficiency (HP:0004430)3.25696489
28Retrobulbar optic neuritis (HP:0100654)3.17204897
29Optic neuritis (HP:0100653)3.17204897
30Combined immunodeficiency (HP:0005387)3.07926742
31Spontaneous hematomas (HP:0007420)3.07379217
32IgG deficiency (HP:0004315)3.06504206
33Abnormality of the heme biosynthetic pathway (HP:0010472)3.04919485
34Stomatitis (HP:0010280)3.02730480
35Gastrointestinal inflammation (HP:0004386)3.02538978
36Inflammation of the large intestine (HP:0002037)3.01649024
37Pustule (HP:0200039)3.01183575
38Orchitis (HP:0100796)2.98285530
39Recurrent bacterial skin infections (HP:0005406)2.95627418
40Acute lymphatic leukemia (HP:0006721)2.95465132
41Abnormal platelet volume (HP:0011876)2.93542043
42Encephalitis (HP:0002383)2.90541363
43Chronic obstructive pulmonary disease (HP:0006510)2.87293356
44Obstructive lung disease (HP:0006536)2.87293356
45Epistaxis (HP:0000421)2.85518303
46Abnormality of cells of the erythroid lineage (HP:0012130)2.84306763
47Vasculitis (HP:0002633)2.81275174
48Lymphopenia (HP:0001888)2.80188280
49Eosinophilia (HP:0001880)2.78841786
50Cellulitis (HP:0100658)2.78738041
51Abnormal number of erythroid precursors (HP:0012131)2.77313247
52Increased IgE level (HP:0003212)2.74513571
53Abnormality of eosinophils (HP:0001879)2.73858874
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.73591212
55Recurrent gram-negative bacterial infections (HP:0005420)2.70606902
56Increased density of long bones (HP:0006392)2.70458950
57Leukocytosis (HP:0001974)2.70451396
58Reticulocytopenia (HP:0001896)2.70024050
59Impaired platelet aggregation (HP:0003540)2.69338217
60Abnormal platelet function (HP:0011869)2.69338217
61Thyroiditis (HP:0100646)2.68013542
62Recurrent skin infections (HP:0001581)2.67968795
63Granulocytopenia (HP:0001913)2.64936841
64Gastrointestinal stroma tumor (HP:0100723)2.64018854
65Chest pain (HP:0100749)2.63770140
66Lymphoma (HP:0002665)2.63327642
67Hemoptysis (HP:0002105)2.62717853
68Arterial thrombosis (HP:0004420)2.58765544
69Mediastinal lymphadenopathy (HP:0100721)2.56811356
70IgA deficiency (HP:0002720)2.56602051
71Urticaria (HP:0001025)2.56230701
72Viral hepatitis (HP:0006562)2.54840970
73Acute myeloid leukemia (HP:0004808)2.53471655
74Verrucae (HP:0200043)2.51695405
75Papilloma (HP:0012740)2.51695405
76Osteomyelitis (HP:0002754)2.47482464
77Increased IgM level (HP:0003496)2.46668554
78Agammaglobulinemia (HP:0004432)2.45166456
79Gingival bleeding (HP:0000225)2.43264397
80Basal cell carcinoma (HP:0002671)2.38205270
81Pulmonary infiltrates (HP:0002113)2.36943359
82Keratoconjunctivitis sicca (HP:0001097)2.34546012
83Autoimmune hemolytic anemia (HP:0001890)2.33904308
84Abnormality of the prostate (HP:0008775)2.33512745
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.33173004
86Increased mean platelet volume (HP:0011877)2.31064416
87Chronic diarrhea (HP:0002028)2.30769175
88Autoimmune thrombocytopenia (HP:0001973)2.30560402
89Hypertensive crisis (HP:0100735)2.26952370
90Poikiloderma (HP:0001029)2.25087824
91Amaurosis fugax (HP:0100576)2.22475035
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.19744261
93Periodontitis (HP:0000704)2.17084786
94Myelodysplasia (HP:0002863)2.16832481
95Gastrointestinal infarctions (HP:0005244)2.16201274
96Joint swelling (HP:0001386)2.15712235
97Skin rash (HP:0000988)2.15135556
98Bronchitis (HP:0012387)2.13403296
99Keratoconjunctivitis (HP:0001096)2.11409429
100Microcytic anemia (HP:0001935)2.09821593
101Colitis (HP:0002583)2.09632405
102Vacuolated lymphocytes (HP:0001922)2.07657039
103Increased cerebral lipofuscin (HP:0011813)2.06210448
104Hypoplasia of the thymus (HP:0000778)2.05797305
105Sepsis (HP:0100806)2.05310666
106Pulmonary embolism (HP:0002204)2.05149533
107Chronic sinusitis (HP:0011109)2.04660460
108Hypochromic microcytic anemia (HP:0004840)2.03615922
109Pallor (HP:0000980)2.02935917
110Aplastic anemia (HP:0001915)2.01868158
111Abnormality of macrophages (HP:0004311)2.00758337
112Gingivitis (HP:0000230)2.00636217
113Prominent nose (HP:0000448)1.99700134
114Entropion (HP:0000621)1.98800552
115Abnormality of the pleura (HP:0002103)1.98761427
116Volvulus (HP:0002580)1.98428466
117Leukopenia (HP:0001882)1.94687065
118Abnormality of iron homeostasis (HP:0011031)1.94021125
119Recurrent sinusitis (HP:0011108)1.93614140
120Hypochromic anemia (HP:0001931)1.93382871
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93340227
122Hypergammaglobulinemia (HP:0010702)1.91895001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.12576597
2RIPK44.51797842
3TXK4.09502112
4EEF2K3.91936796
5PRPF4B3.10587251
6JAK32.96308002
7ZAP702.49320774
8ITK2.40600369
9STK102.37328032
10GRK62.10696356
11TEC2.05521720
12TYK22.05332020
13BTK2.02786713
14PKN21.78179550
15KIT1.73197152
16MAP3K101.70424097
17SYK1.58348297
18IKBKE1.57932181
19FGFR41.57238191
20LCK1.51932219
21TRIB31.50510755
22TAOK31.49170955
23FGFR31.49017456
24CDC71.48923489
25NME21.47665726
26LRRK21.45669397
27CDK121.45535119
28IRAK41.39945975
29JAK11.37529272
30FES1.35769301
31PIM11.34172992
32MAP2K31.32829548
33MAP3K141.31773195
34HCK1.30220574
35SMG11.28685010
36RPS6KB21.25719373
37NEK21.21570201
38TBK11.19860287
39CDK41.17369835
40BLK1.16975811
41CLK11.16689163
42CSK1.16371611
43RPS6KA41.12339506
44PIK3CG1.09725083
45TNK21.08061619
46TLK11.06405397
47SIK21.06355574
48BMPR21.05765895
49CSF1R1.05392999
50PASK1.02150066
51NLK1.01698726
52TESK20.96731884
53EPHB10.96141756
54TGFBR10.95748610
55MATK0.95204996
56ALK0.93745525
57TSSK60.92502459
58FLT30.92460828
59IKBKB0.91535497
60STK40.91165585
61TRPM70.86370162
62LYN0.85206822
63JAK20.85068278
64MAPK120.81911960
65MARK30.78711855
66ATR0.78695369
67KDR0.75083648
68CDK60.72022436
69MAP3K10.71953510
70FRK0.70719634
71MAP3K70.69617019
72BRD40.69342909
73HIPK20.69211804
74MAP3K80.66827088
75TAOK10.65611994
76VRK10.65600661
77STK240.64189869
78CHUK0.62979028
79TTN0.61851154
80MST40.61342463
81PRKCH0.59467074
82NEK90.58003009
83CAMKK20.56321572
84NUAK10.56108833
85RAF10.54818178
86CDK90.53856478
87ZAK0.53606812
88CAMKK10.51992186
89MAPK40.51693807
90PTK60.51291110
91FGR0.49673470
92PIM20.49216021
93RPS6KA60.48402889
94TGFBR20.47898080
95WEE10.47561740
96IRAK30.46588002
97IRAK10.46328141
98PDK10.45353084
99MARK20.45016078
100YES10.44496613
101CDK70.44115754
102MAPK70.43528553
103AURKB0.43422996
104ACVR1B0.42120644
105MAPK30.41828759
106* PRKCQ0.41736249
107CHEK10.40982379
108MAPK110.40211437
109RPS6KL10.39170500
110RPS6KC10.39170500
111BCKDK0.38580082
112MAP2K60.37598221
113SIK30.37136856
114CCNB10.36639763
115MELK0.36626965
116MAPKAPK20.36423334
117MKNK10.35733682
118ERN10.35163456
119MAP2K20.34765646
120TAOK20.34581067
121MAP3K130.34026349
122CDC42BPA0.33699352
123PDPK10.33107991
124RPS6KA50.32701737
125KSR20.32431796
126MAPKAPK30.31937078
127MAP3K110.31325229
128ILK0.30599826
129DYRK30.30035664
130SRPK10.29373326
131PDGFRB0.29318621

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.00046478
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78105922
3DNA replication_Homo sapiens_hsa030302.61362390
4T cell receptor signaling pathway_Homo sapiens_hsa046602.59476661
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.48199905
6Antigen processing and presentation_Homo sapiens_hsa046122.34790736
7Measles_Homo sapiens_hsa051622.33445957
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.26758184
9Ribosome_Homo sapiens_hsa030102.19879081
10Leishmaniasis_Homo sapiens_hsa051402.15908452
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.11430401
12B cell receptor signaling pathway_Homo sapiens_hsa046622.02850372
13Hematopoietic cell lineage_Homo sapiens_hsa046401.92608253
14Graft-versus-host disease_Homo sapiens_hsa053321.87672038
15Allograft rejection_Homo sapiens_hsa053301.84145247
16Osteoclast differentiation_Homo sapiens_hsa043801.81914466
17Mismatch repair_Homo sapiens_hsa034301.76992537
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.63837089
19Base excision repair_Homo sapiens_hsa034101.60409345
20Herpes simplex infection_Homo sapiens_hsa051681.60048104
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57186995
22Acute myeloid leukemia_Homo sapiens_hsa052211.53158778
23Spliceosome_Homo sapiens_hsa030401.53066592
24Non-homologous end-joining_Homo sapiens_hsa034501.49777324
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45903633
26Asthma_Homo sapiens_hsa053101.45734872
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45198638
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45126975
29Viral myocarditis_Homo sapiens_hsa054161.39550463
30Hepatitis B_Homo sapiens_hsa051611.37213173
31Chronic myeloid leukemia_Homo sapiens_hsa052201.33254012
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29695831
33Toxoplasmosis_Homo sapiens_hsa051451.27979560
34Autoimmune thyroid disease_Homo sapiens_hsa053201.26048324
35Homologous recombination_Homo sapiens_hsa034401.25015439
36Shigellosis_Homo sapiens_hsa051311.24600587
37Cell cycle_Homo sapiens_hsa041101.21715086
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.20924444
39Chemokine signaling pathway_Homo sapiens_hsa040621.18231232
40Platelet activation_Homo sapiens_hsa046111.17617136
41Apoptosis_Homo sapiens_hsa042101.14688622
42Influenza A_Homo sapiens_hsa051641.10660155
43HTLV-I infection_Homo sapiens_hsa051661.09549895
44Viral carcinogenesis_Homo sapiens_hsa052031.09013522
45Pancreatic cancer_Homo sapiens_hsa052121.08827676
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08658019
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07653062
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07285666
49Legionellosis_Homo sapiens_hsa051341.04817442
50RNA transport_Homo sapiens_hsa030131.01844310
51Rheumatoid arthritis_Homo sapiens_hsa053231.01302375
52* Epstein-Barr virus infection_Homo sapiens_hsa051690.99133049
53Nucleotide excision repair_Homo sapiens_hsa034200.98051592
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97694510
55One carbon pool by folate_Homo sapiens_hsa006700.94852247
56RNA degradation_Homo sapiens_hsa030180.93687139
57TNF signaling pathway_Homo sapiens_hsa046680.92847544
58Non-small cell lung cancer_Homo sapiens_hsa052230.91481241
59Fanconi anemia pathway_Homo sapiens_hsa034600.86584145
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85324635
61p53 signaling pathway_Homo sapiens_hsa041150.84402328
62Tuberculosis_Homo sapiens_hsa051520.83355321
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81642213
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81479782
65Colorectal cancer_Homo sapiens_hsa052100.80958133
66mRNA surveillance pathway_Homo sapiens_hsa030150.80608175
67Malaria_Homo sapiens_hsa051440.75209133
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.75204571
69African trypanosomiasis_Homo sapiens_hsa051430.75056909
70Pertussis_Homo sapiens_hsa051330.74112275
71Small cell lung cancer_Homo sapiens_hsa052220.73379847
72Prolactin signaling pathway_Homo sapiens_hsa049170.72690126
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71434934
74Phagosome_Homo sapiens_hsa041450.67775562
75VEGF signaling pathway_Homo sapiens_hsa043700.67756178
76Type I diabetes mellitus_Homo sapiens_hsa049400.67064337
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66146030
78Hepatitis C_Homo sapiens_hsa051600.66115080
79Pyrimidine metabolism_Homo sapiens_hsa002400.65241632
80Alcoholism_Homo sapiens_hsa050340.62997696
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61165463
82Salmonella infection_Homo sapiens_hsa051320.61063019
83Dorso-ventral axis formation_Homo sapiens_hsa043200.57528459
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57052281
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56363910
86Staphylococcus aureus infection_Homo sapiens_hsa051500.55631029
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51873185
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51785266
89Pentose phosphate pathway_Homo sapiens_hsa000300.49586094
90* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46857364
91Notch signaling pathway_Homo sapiens_hsa043300.46362012
92HIF-1 signaling pathway_Homo sapiens_hsa040660.45644605
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45520944
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44634287
95MicroRNAs in cancer_Homo sapiens_hsa052060.44240718
96FoxO signaling pathway_Homo sapiens_hsa040680.42989923
97Systemic lupus erythematosus_Homo sapiens_hsa053220.42656000
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42217018
99RNA polymerase_Homo sapiens_hsa030200.41905848
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41590108
101N-Glycan biosynthesis_Homo sapiens_hsa005100.40517745
102mTOR signaling pathway_Homo sapiens_hsa041500.39705211
103Other glycan degradation_Homo sapiens_hsa005110.38455820
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.36886478
105Thyroid cancer_Homo sapiens_hsa052160.36740354
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36648941
107Renal cell carcinoma_Homo sapiens_hsa052110.36534125
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36197542
109Type II diabetes mellitus_Homo sapiens_hsa049300.35302501
110Lysosome_Homo sapiens_hsa041420.33069690
111Prostate cancer_Homo sapiens_hsa052150.32728820
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32642506
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32263295
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.31278845
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31109296
116Inositol phosphate metabolism_Homo sapiens_hsa005620.30950287
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30694775
118Choline metabolism in cancer_Homo sapiens_hsa052310.29676621
119Insulin resistance_Homo sapiens_hsa049310.29397279
120MAPK signaling pathway_Homo sapiens_hsa040100.27020085
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.24138277
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.24064193
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22984124
124Endometrial cancer_Homo sapiens_hsa052130.21589604
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16023998

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