

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.54818488 |
| 2 | negative regulation of B cell apoptotic process (GO:0002903) | 5.50115009 |
| 3 | purine deoxyribonucleotide catabolic process (GO:0009155) | 4.93741402 |
| 4 | negative regulation of phagocytosis (GO:0050765) | 4.90556719 |
| 5 | positive regulation of B cell differentiation (GO:0045579) | 4.73481362 |
| 6 | DNA deamination (GO:0045006) | 4.63083678 |
| 7 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.49036190 |
| 8 | positive regulation of granulocyte differentiation (GO:0030854) | 4.26771529 |
| 9 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.23429413 |
| 10 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.23429413 |
| 11 | positive thymic T cell selection (GO:0045059) | 4.21604155 |
| 12 | B cell mediated immunity (GO:0019724) | 4.18248250 |
| 13 | response to peptidoglycan (GO:0032494) | 4.15452390 |
| 14 | deoxyribose phosphate catabolic process (GO:0046386) | 4.08696186 |
| 15 | deoxyribonucleotide catabolic process (GO:0009264) | 4.07602073 |
| 16 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.01968340 |
| 17 | cellular extravasation (GO:0045123) | 3.94660432 |
| 18 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.90862740 |
| 19 | telomere maintenance via recombination (GO:0000722) | 3.89855532 |
| 20 | DNA strand elongation (GO:0022616) | 3.87938134 |
| 21 | negative thymic T cell selection (GO:0045060) | 3.77955461 |
| 22 | regulation of B cell differentiation (GO:0045577) | 3.77630165 |
| 23 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.75059563 |
| 24 | Peyers patch development (GO:0048541) | 3.75059563 |
| 25 | negative T cell selection (GO:0043383) | 3.68964388 |
| 26 | mature B cell differentiation involved in immune response (GO:0002313) | 3.64682826 |
| 27 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.62949066 |
| 28 | mitotic recombination (GO:0006312) | 3.62761064 |
| 29 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.62060384 |
| 30 | cellular response to zinc ion (GO:0071294) | 3.61221934 |
| 31 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.55883690 |
| 32 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.55226039 |
| 33 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.54468994 |
| 34 | purine deoxyribonucleotide metabolic process (GO:0009151) | 3.52669281 |
| 35 | viral transcription (GO:0019083) | 3.51850652 |
| 36 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.50869757 |
| 37 | B cell receptor signaling pathway (GO:0050853) | 3.49735005 |
| 38 | mast cell activation (GO:0045576) | 3.49023375 |
| 39 | autophagic vacuole fusion (GO:0000046) | 3.47938900 |
| 40 | microglial cell activation (GO:0001774) | 3.47824800 |
| 41 | neutrophil mediated immunity (GO:0002446) | 3.41391471 |
| 42 | telomere maintenance via telomere lengthening (GO:0010833) | 3.40820796 |
| 43 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.39398217 |
| 44 | positive T cell selection (GO:0043368) | 3.38107926 |
| 45 | positive regulation of antigen processing and presentation (GO:0002579) | 3.36565485 |
| 46 | translational termination (GO:0006415) | 3.34362643 |
| 47 | definitive hemopoiesis (GO:0060216) | 3.32389668 |
| 48 | regulation of germinal center formation (GO:0002634) | 3.31722672 |
| 49 | neutrophil activation involved in immune response (GO:0002283) | 3.30850804 |
| 50 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.28324314 |
| 51 | purine nucleotide salvage (GO:0032261) | 3.26392007 |
| 52 | regulation of gamma-delta T cell activation (GO:0046643) | 3.23083020 |
| 53 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.22196401 |
| 54 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.20297421 |
| 55 | cotranslational protein targeting to membrane (GO:0006613) | 3.18866539 |
| 56 | T cell migration (GO:0072678) | 3.17961981 |
| 57 | DNA replication initiation (GO:0006270) | 3.17780968 |
| 58 | response to muramyl dipeptide (GO:0032495) | 3.17095907 |
| 59 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.15731887 |
| 60 | protein targeting to ER (GO:0045047) | 3.15596182 |
| 61 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.14386433 |
| 62 | platelet dense granule organization (GO:0060155) | 3.13948502 |
| 63 | T cell homeostasis (GO:0043029) | 3.13063617 |
| 64 | lymphoid progenitor cell differentiation (GO:0002320) | 3.11444759 |
| 65 | leukocyte degranulation (GO:0043299) | 3.11197838 |
| 66 | defense response to protozoan (GO:0042832) | 3.10966149 |
| 67 | deoxyribose phosphate metabolic process (GO:0019692) | 3.10668068 |
| 68 | regulation of granulocyte differentiation (GO:0030852) | 3.10530172 |
| 69 | myeloid cell activation involved in immune response (GO:0002275) | 3.10069194 |
| 70 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.09127217 |
| 71 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.08974581 |
| 72 | DNA unwinding involved in DNA replication (GO:0006268) | 3.08921589 |
| 73 | regulation of antigen processing and presentation (GO:0002577) | 3.08395133 |
| 74 | regulation of leukocyte degranulation (GO:0043300) | 3.07694751 |
| 75 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.07311922 |
| 76 | detection of bacterium (GO:0016045) | 3.07016033 |
| 77 | polyketide metabolic process (GO:0030638) | 3.06548409 |
| 78 | doxorubicin metabolic process (GO:0044598) | 3.06548409 |
| 79 | daunorubicin metabolic process (GO:0044597) | 3.06548409 |
| 80 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.06385248 |
| 81 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.06385248 |
| 82 | modulation by symbiont of host immune response (GO:0052553) | 3.06385248 |
| 83 | positive regulation by symbiont of host defense response (GO:0052509) | 3.06385248 |
| 84 | modulation by symbiont of host defense response (GO:0052031) | 3.06385248 |
| 85 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.06385248 |
| 86 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.06295168 |
| 87 | T cell selection (GO:0045058) | 3.05886229 |
| 88 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.03654249 |
| 89 | megakaryocyte development (GO:0035855) | 3.03632805 |
| 90 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.03273098 |
| 91 | protein localization to endoplasmic reticulum (GO:0070972) | 3.00465834 |
| 92 | ribosomal small subunit biogenesis (GO:0042274) | 2.99401550 |
| 93 | response to protozoan (GO:0001562) | 2.97155462 |
| 94 | translational elongation (GO:0006414) | 2.97082013 |
| 95 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.96984342 |
| 96 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.94986629 |
| 97 | histamine transport (GO:0051608) | 2.94883111 |
| 98 | detection of other organism (GO:0098543) | 2.94515815 |
| 99 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.94309571 |
| 100 | regulation of growth of symbiont in host (GO:0044126) | 2.94309571 |
| 101 | negative regulation of growth of symbiont in host (GO:0044130) | 2.94309571 |
| 102 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.94309571 |
| 103 | angiogenesis involved in wound healing (GO:0060055) | 2.92199555 |
| 104 | respiratory burst (GO:0045730) | 2.91051246 |
| 105 | thymic T cell selection (GO:0045061) | 2.90311111 |
| 106 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.90079135 |
| 107 | response to interferon-beta (GO:0035456) | 2.88940284 |
| 108 | DNA ligation (GO:0006266) | 2.88631681 |
| 109 | DNA topological change (GO:0006265) | 2.85435515 |
| 110 | myeloid dendritic cell activation (GO:0001773) | 2.83050324 |
| 111 | regulation of hypersensitivity (GO:0002883) | 2.82980384 |
| 112 | positive regulation of B cell activation (GO:0050871) | 2.80469841 |
| 113 | myeloid leukocyte mediated immunity (GO:0002444) | 2.80329262 |
| 114 | histamine secretion (GO:0001821) | 2.78862450 |
| 115 | mature B cell differentiation (GO:0002335) | 2.78456445 |
| 116 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.78337790 |
| 117 | nucleotide salvage (GO:0043173) | 2.78278653 |
| 118 | fucose catabolic process (GO:0019317) | 2.77426122 |
| 119 | L-fucose metabolic process (GO:0042354) | 2.77426122 |
| 120 | L-fucose catabolic process (GO:0042355) | 2.77426122 |
| 121 | actin nucleation (GO:0045010) | 2.76750938 |
| 122 | immunoglobulin mediated immune response (GO:0016064) | 2.76316820 |
| 123 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.75597743 |
| 124 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.75425385 |
| 125 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.74511655 |
| 126 | pinocytosis (GO:0006907) | 2.71911998 |
| 127 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.71312981 |
| 128 | cellular response to exogenous dsRNA (GO:0071360) | 2.70976445 |
| 129 | base-excision repair, AP site formation (GO:0006285) | 2.70407549 |
| 130 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.70270479 |
| 131 | regulation of mast cell activation (GO:0033003) | 2.69944489 |
| 132 | neutrophil activation (GO:0042119) | 2.69104555 |
| 133 | DNA replication checkpoint (GO:0000076) | 2.68066147 |
| 134 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.67799813 |
| 135 | mast cell degranulation (GO:0043303) | 2.67639352 |
| 136 | mast cell activation involved in immune response (GO:0002279) | 2.67639352 |
| 137 | regulation of mast cell degranulation (GO:0043304) | 2.67604664 |
| 138 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 2.67387333 |
| 139 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.67257075 |
| 140 | telomere organization (GO:0032200) | 2.66939890 |
| 141 | organelle membrane fusion (GO:0090174) | 2.66612368 |
| 142 | telomere maintenance (GO:0000723) | 2.64630039 |
| 143 | cellular response to interferon-beta (GO:0035458) | 2.62877617 |
| 144 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 2.61526847 |
| 145 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 2.61526847 |
| 146 | necroptotic process (GO:0070266) | 2.61345576 |
| 147 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.60875090 |
| 148 | secretory granule organization (GO:0033363) | 2.60527633 |
| 149 | CENP-A containing nucleosome assembly (GO:0034080) | 2.60394885 |
| 150 | lymphocyte homeostasis (GO:0002260) | 2.59550328 |
| 151 | leukocyte aggregation (GO:0070486) | 2.58760650 |
| 152 | response to fungus (GO:0009620) | 2.57830396 |
| 153 | viral life cycle (GO:0019058) | 2.57164883 |
| 154 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.56745863 |
| 155 | positive regulation of mast cell degranulation (GO:0043306) | 2.56745863 |
| 156 | maturation of SSU-rRNA (GO:0030490) | 2.54883945 |
| 157 | cellular protein complex disassembly (GO:0043624) | 2.50532012 |
| 158 | NIK/NF-kappaB signaling (GO:0038061) | 2.50199373 |
| 159 | regulation of necroptotic process (GO:0060544) | 2.49599875 |
| 160 | regulation of B cell apoptotic process (GO:0002902) | 2.48479271 |
| 161 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.47325444 |
| 162 | translational initiation (GO:0006413) | 2.45277175 |
| 163 | chromatin remodeling at centromere (GO:0031055) | 2.43195107 |
| 164 | positive regulation of mast cell activation (GO:0033005) | 2.43170035 |
| 165 | leukocyte mediated cytotoxicity (GO:0001909) | 2.43052104 |
| 166 | dendritic cell chemotaxis (GO:0002407) | 2.42921155 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.77886848 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.47019704 |
| 3 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.26666694 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.19350382 |
| 5 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.05594914 |
| 6 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.95154196 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.94415066 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.91138136 |
| 9 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.88642974 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.86173204 |
| 11 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.85258530 |
| 12 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.79105370 |
| 13 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.61732929 |
| 14 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.51825204 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.51473583 |
| 16 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.49282598 |
| 17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.48242903 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.44632862 |
| 19 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.43895545 |
| 20 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.39729659 |
| 21 | MYC_22102868_ChIP-Seq_BL_Human | 2.31407449 |
| 22 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.28599718 |
| 23 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.28202571 |
| 24 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.26235977 |
| 25 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.18235281 |
| 26 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.06967268 |
| 27 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.01946106 |
| 28 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 2.01874172 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.01393756 |
| 30 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00033959 |
| 31 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.93980574 |
| 32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.92750062 |
| 33 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.92396558 |
| 34 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.91267303 |
| 35 | MYB_26560356_Chip-Seq_TH2_Human | 1.88934755 |
| 36 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.88736562 |
| 37 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.87671084 |
| 38 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.85270455 |
| 39 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.82912143 |
| 40 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.81366200 |
| 41 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.81282105 |
| 42 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.80967565 |
| 43 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.80855286 |
| 44 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.79026330 |
| 45 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.77981786 |
| 46 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72426151 |
| 47 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.71140031 |
| 48 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.70785392 |
| 49 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.67234442 |
| 50 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.65183441 |
| 51 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.62805530 |
| 52 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.62266301 |
| 53 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.58162175 |
| 54 | MYB_26560356_Chip-Seq_TH1_Human | 1.57592959 |
| 55 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.56684105 |
| 56 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.56238826 |
| 57 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.55791586 |
| 58 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.55475156 |
| 59 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54408672 |
| 60 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.53170515 |
| 61 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.53167866 |
| 62 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.52080293 |
| 63 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.51946504 |
| 64 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.51484911 |
| 65 | GATA1_22025678_ChIP-Seq_K562_Human | 1.51258701 |
| 66 | MAF_26560356_Chip-Seq_TH1_Human | 1.51150097 |
| 67 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.47548837 |
| 68 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.47497701 |
| 69 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.46507618 |
| 70 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.44938797 |
| 71 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.44505683 |
| 72 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.42356859 |
| 73 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.41556788 |
| 74 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.40769899 |
| 75 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.39670947 |
| 76 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.38148012 |
| 77 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.34647662 |
| 78 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.34138466 |
| 79 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.33734066 |
| 80 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.33130107 |
| 81 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.32228972 |
| 82 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.29782511 |
| 83 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.25975591 |
| 84 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.24327308 |
| 85 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.22956111 |
| 86 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.21731016 |
| 87 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.19399982 |
| 88 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.19157557 |
| 89 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.19030988 |
| 90 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.17696858 |
| 91 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.17116162 |
| 92 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.16546666 |
| 93 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.16388350 |
| 94 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.15671045 |
| 95 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.15371854 |
| 96 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.14439367 |
| 97 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.13392139 |
| 98 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.12707377 |
| 99 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.12050619 |
| 100 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.11216771 |
| 101 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.10413424 |
| 102 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.10226100 |
| 103 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.10145909 |
| 104 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.09717083 |
| 105 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.08872171 |
| 106 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.08608465 |
| 107 | P300_27268052_Chip-Seq_Bcells_Human | 1.06594099 |
| 108 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.06092824 |
| 109 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.05886726 |
| 110 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.04918027 |
| 111 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.04487002 |
| 112 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.02626661 |
| 113 | P68_20966046_ChIP-Seq_HELA_Human | 1.01946556 |
| 114 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.01777579 |
| 115 | SPI1_23127762_ChIP-Seq_K562_Human | 1.01004925 |
| 116 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00977064 |
| 117 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.98804805 |
| 118 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.98679566 |
| 119 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.96272939 |
| 120 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.95801953 |
| 121 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.94904767 |
| 122 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94649310 |
| 123 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.93646959 |
| 124 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92364440 |
| 125 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91013853 |
| 126 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90161028 |
| 127 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.90138815 |
| 128 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.89015246 |
| 129 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.85822076 |
| 130 | MAF_26560356_Chip-Seq_TH2_Human | 0.84704285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002396_abnormal_hematopoietic_system | 4.41548336 |
| 2 | MP0001835_abnormal_antigen_presentation | 4.30354045 |
| 3 | MP0009785_altered_susceptibility_to | 2.97193025 |
| 4 | MP0001800_abnormal_humoral_immune | 2.64358532 |
| 5 | MP0000685_abnormal_immune_system | 2.59207263 |
| 6 | MP0005671_abnormal_response_to | 2.57259078 |
| 7 | MP0005025_abnormal_response_to | 2.56338801 |
| 8 | MP0005397_hematopoietic_system_phenotyp | 2.51147740 |
| 9 | MP0001545_abnormal_hematopoietic_system | 2.51147740 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.50085746 |
| 11 | MP0002419_abnormal_innate_immunity | 2.49681111 |
| 12 | MP0003436_decreased_susceptibility_to | 2.49361689 |
| 13 | MP0002452_abnormal_antigen_presenting | 2.48644655 |
| 14 | MP0002398_abnormal_bone_marrow | 2.46316851 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.44904017 |
| 16 | MP0003693_abnormal_embryo_hatching | 2.44363710 |
| 17 | MP0001819_abnormal_immune_cell | 2.42695965 |
| 18 | MP0005000_abnormal_immune_tolerance | 2.41754738 |
| 19 | MP0005174_abnormal_tail_pigmentation | 2.41604062 |
| 20 | MP0010094_abnormal_chromosome_stability | 2.36360830 |
| 21 | MP0001790_abnormal_immune_system | 2.33778575 |
| 22 | MP0005387_immune_system_phenotype | 2.33778575 |
| 23 | MP0002723_abnormal_immune_serum | 2.33023502 |
| 24 | MP0005464_abnormal_platelet_physiology | 2.32934168 |
| 25 | MP0004808_abnormal_hematopoietic_stem | 2.29921702 |
| 26 | MP0002166_altered_tumor_susceptibility | 2.23636003 |
| 27 | MP0000465_gastrointestinal_hemorrhage | 2.20665444 |
| 28 | MP0000716_abnormal_immune_system | 2.17531164 |
| 29 | MP0000490_abnormal_crypts_of | 2.16992495 |
| 30 | MP0008057_abnormal_DNA_replication | 2.16900213 |
| 31 | MP0003763_abnormal_thymus_physiology | 2.14637259 |
| 32 | MP0005075_abnormal_melanosome_morpholog | 2.12395547 |
| 33 | MP0001853_heart_inflammation | 2.11856271 |
| 34 | MP0000689_abnormal_spleen_morphology | 2.08095797 |
| 35 | MP0002006_tumorigenesis | 1.98717405 |
| 36 | MP0002722_abnormal_immune_system | 1.97635227 |
| 37 | MP0002429_abnormal_blood_cell | 1.94468008 |
| 38 | MP0003724_increased_susceptibility_to | 1.83770941 |
| 39 | MP0008058_abnormal_DNA_repair | 1.77286985 |
| 40 | MP0010155_abnormal_intestine_physiology | 1.76393173 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.76230927 |
| 42 | MP0003077_abnormal_cell_cycle | 1.75691452 |
| 43 | MP0003111_abnormal_nucleus_morphology | 1.75578941 |
| 44 | MP0008007_abnormal_cellular_replicative | 1.73095487 |
| 45 | MP0005451_abnormal_body_composition | 1.69376048 |
| 46 | MP0002095_abnormal_skin_pigmentation | 1.62318008 |
| 47 | MP0003303_peritoneal_inflammation | 1.59694372 |
| 48 | MP0003806_abnormal_nucleotide_metabolis | 1.58588262 |
| 49 | MP0001873_stomach_inflammation | 1.57252863 |
| 50 | MP0002405_respiratory_system_inflammati | 1.56934803 |
| 51 | MP0001845_abnormal_inflammatory_respons | 1.56796935 |
| 52 | MP0000015_abnormal_ear_pigmentation | 1.56410305 |
| 53 | MP0009697_abnormal_copulation | 1.56093395 |
| 54 | MP0000703_abnormal_thymus_morphology | 1.52559339 |
| 55 | MP0003191_abnormal_cellular_cholesterol | 1.44730023 |
| 56 | MP0006054_spinal_hemorrhage | 1.43834124 |
| 57 | MP0003866_abnormal_defecation | 1.43274437 |
| 58 | MP0002019_abnormal_tumor_incidence | 1.38972894 |
| 59 | MP0002009_preneoplasia | 1.37992721 |
| 60 | MP0009278_abnormal_bone_marrow | 1.36914917 |
| 61 | MP0004957_abnormal_blastocyst_morpholog | 1.36450935 |
| 62 | MP0000858_altered_metastatic_potential | 1.30078967 |
| 63 | MP0001986_abnormal_taste_sensitivity | 1.26860196 |
| 64 | MP0008469_abnormal_protein_level | 1.21605722 |
| 65 | MP0002132_abnormal_respiratory_system | 1.17581387 |
| 66 | MP0004147_increased_porphyrin_level | 1.12753116 |
| 67 | MP0003656_abnormal_erythrocyte_physiolo | 1.12450212 |
| 68 | MP0002822_catalepsy | 1.11242871 |
| 69 | MP0005084_abnormal_gallbladder_morpholo | 1.10883958 |
| 70 | MP0003183_abnormal_peptide_metabolism | 1.05063540 |
| 71 | MP0003172_abnormal_lysosome_physiology | 1.04294858 |
| 72 | MP0001851_eye_inflammation | 1.01868983 |
| 73 | MP0001533_abnormal_skeleton_physiology | 1.01805383 |
| 74 | MP0003787_abnormal_imprinting | 0.99456208 |
| 75 | MP0009765_abnormal_xenobiotic_induced | 0.99403494 |
| 76 | MP0009764_decreased_sensitivity_to | 0.98079186 |
| 77 | MP0009379_abnormal_foot_pigmentation | 0.97541342 |
| 78 | MP0005409_darkened_coat_color | 0.97513966 |
| 79 | MP0003186_abnormal_redox_activity | 0.95060944 |
| 80 | MP0008260_abnormal_autophagy | 0.92373348 |
| 81 | MP0000313_abnormal_cell_death | 0.91773928 |
| 82 | MP0001764_abnormal_homeostasis | 0.86172790 |
| 83 | MP0005166_decreased_susceptibility_to | 0.84938884 |
| 84 | MP0006035_abnormal_mitochondrial_morpho | 0.83735530 |
| 85 | MP0005220_abnormal_exocrine_pancreas | 0.80780475 |
| 86 | MP0000343_altered_response_to | 0.79874492 |
| 87 | MP0004947_skin_inflammation | 0.79871724 |
| 88 | MP0001663_abnormal_digestive_system | 0.79753979 |
| 89 | MP0010307_abnormal_tumor_latency | 0.76770666 |
| 90 | MP0003828_pulmonary_edema | 0.76333945 |
| 91 | MP0002933_joint_inflammation | 0.74697539 |
| 92 | MP0003300_gastrointestinal_ulcer | 0.73954688 |
| 93 | MP0003943_abnormal_hepatobiliary_system | 0.72343196 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.71559977 |
| 95 | MP0000371_diluted_coat_color | 0.71545107 |
| 96 | MP0003638_abnormal_response/metabolism_ | 0.71478429 |
| 97 | MP0003786_premature_aging | 0.71360214 |
| 98 | MP0009840_abnormal_foam_cell | 0.70994835 |
| 99 | MP0009763_increased_sensitivity_to | 0.70116538 |
| 100 | MP0000350_abnormal_cell_proliferation | 0.69211375 |
| 101 | MP0005058_abnormal_lysosome_morphology | 0.68760892 |
| 102 | MP0002075_abnormal_coat/hair_pigmentati | 0.68699190 |
| 103 | MP0002928_abnormal_bile_duct | 0.68524713 |
| 104 | MP0005310_abnormal_salivary_gland | 0.68124312 |
| 105 | MP0006082_CNS_inflammation | 0.66579104 |
| 106 | MP0008995_early_reproductive_senescence | 0.64840049 |
| 107 | MP0006292_abnormal_olfactory_placode | 0.64500505 |
| 108 | MP0001188_hyperpigmentation | 0.63490666 |
| 109 | MP0003252_abnormal_bile_duct | 0.63338151 |
| 110 | MP0005319_abnormal_enzyme/_coenzyme | 0.63073473 |
| 111 | MP0005390_skeleton_phenotype | 0.61271252 |
| 112 | MP0001905_abnormal_dopamine_level | 0.61197749 |
| 113 | MP0004185_abnormal_adipocyte_glucose | 0.61075208 |
| 114 | MP0005535_abnormal_body_temperature | 0.59894988 |
| 115 | MP0003448_altered_tumor_morphology | 0.59403086 |
| 116 | MP0004381_abnormal_hair_follicle | 0.57584454 |
| 117 | MP0006036_abnormal_mitochondrial_physio | 0.53631132 |
| 118 | MP0008873_increased_physiological_sensi | 0.52748060 |
| 119 | MP0000249_abnormal_blood_vessel | 0.51263636 |
| 120 | MP0000681_abnormal_thyroid_gland | 0.50064163 |
| 121 | MP0008877_abnormal_DNA_methylation | 0.49936892 |
| 122 | MP0000477_abnormal_intestine_morphology | 0.49662099 |
| 123 | MP0002876_abnormal_thyroid_physiology | 0.48472952 |
| 124 | MP0003075_altered_response_to | 0.48362426 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chronic otitis media (HP:0000389) | 5.01930969 |
| 2 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.59927780 |
| 3 | Thrombocytosis (HP:0001894) | 4.56332177 |
| 4 | Recurrent abscess formation (HP:0002722) | 4.54495628 |
| 5 | Panhypogammaglobulinemia (HP:0003139) | 4.52190490 |
| 6 | Recurrent viral infections (HP:0004429) | 4.34085624 |
| 7 | Recurrent bacterial skin infections (HP:0005406) | 4.32260035 |
| 8 | IgM deficiency (HP:0002850) | 4.28161623 |
| 9 | Agammaglobulinemia (HP:0004432) | 4.22770631 |
| 10 | Petechiae (HP:0000967) | 3.93295317 |
| 11 | Increased IgE level (HP:0003212) | 3.92289036 |
| 12 | Abnormal number of erythroid precursors (HP:0012131) | 3.86244670 |
| 13 | Autoimmune hemolytic anemia (HP:0001890) | 3.83899463 |
| 14 | Stomatitis (HP:0010280) | 3.83550322 |
| 15 | Meningitis (HP:0001287) | 3.82243940 |
| 16 | Myositis (HP:0100614) | 3.68744671 |
| 17 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.66413393 |
| 18 | Severe combined immunodeficiency (HP:0004430) | 3.62507884 |
| 19 | Reduced antithrombin III activity (HP:0001976) | 3.62123788 |
| 20 | Cellulitis (HP:0100658) | 3.59868303 |
| 21 | Aplastic anemia (HP:0001915) | 3.50382030 |
| 22 | Abnormality of the prostate (HP:0008775) | 3.45324435 |
| 23 | Reticulocytopenia (HP:0001896) | 3.44258902 |
| 24 | Abnormality of T cell physiology (HP:0011840) | 3.43580030 |
| 25 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.42102154 |
| 26 | Recurrent fungal infections (HP:0002841) | 3.39395563 |
| 27 | Type I transferrin isoform profile (HP:0003642) | 3.37708604 |
| 28 | Autoimmune thrombocytopenia (HP:0001973) | 3.22515306 |
| 29 | Recurrent skin infections (HP:0001581) | 3.14339531 |
| 30 | B lymphocytopenia (HP:0010976) | 3.00508568 |
| 31 | Abnormality of B cell number (HP:0010975) | 3.00508568 |
| 32 | Recurrent bronchitis (HP:0002837) | 2.97453296 |
| 33 | Mediastinal lymphadenopathy (HP:0100721) | 2.92460078 |
| 34 | Combined immunodeficiency (HP:0005387) | 2.92026965 |
| 35 | Encephalitis (HP:0002383) | 2.89882987 |
| 36 | Hypergammaglobulinemia (HP:0010702) | 2.89530198 |
| 37 | Abnormal protein glycosylation (HP:0012346) | 2.85256536 |
| 38 | Abnormal glycosylation (HP:0012345) | 2.85256536 |
| 39 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.85256536 |
| 40 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.85256536 |
| 41 | Inflammation of the large intestine (HP:0002037) | 2.83895017 |
| 42 | Eczematoid dermatitis (HP:0000976) | 2.83178679 |
| 43 | Prolonged bleeding time (HP:0003010) | 2.76817769 |
| 44 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.76479161 |
| 45 | Recurrent cutaneous fungal infections (HP:0011370) | 2.76479161 |
| 46 | Chest pain (HP:0100749) | 2.75604716 |
| 47 | Gastrointestinal inflammation (HP:0004386) | 2.72920312 |
| 48 | Increased IgM level (HP:0003496) | 2.72586243 |
| 49 | Obstructive lung disease (HP:0006536) | 2.71344949 |
| 50 | Chronic obstructive pulmonary disease (HP:0006510) | 2.71344949 |
| 51 | Colitis (HP:0002583) | 2.66727867 |
| 52 | Abnormality of T cells (HP:0002843) | 2.61423237 |
| 53 | Abnormality of eosinophils (HP:0001879) | 2.59281979 |
| 54 | Type 2 muscle fiber atrophy (HP:0003554) | 2.59265696 |
| 55 | Chromsome breakage (HP:0040012) | 2.57353497 |
| 56 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.52143606 |
| 57 | Urticaria (HP:0001025) | 2.46951696 |
| 58 | Muscle fiber atrophy (HP:0100295) | 2.46377150 |
| 59 | IgG deficiency (HP:0004315) | 2.41574138 |
| 60 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.40495261 |
| 61 | Neutropenia (HP:0001875) | 2.40133555 |
| 62 | Acute lymphatic leukemia (HP:0006721) | 2.38438435 |
| 63 | 11 pairs of ribs (HP:0000878) | 2.38311865 |
| 64 | Osteomyelitis (HP:0002754) | 2.37037417 |
| 65 | Lymphoma (HP:0002665) | 2.36194214 |
| 66 | Vasculitis (HP:0002633) | 2.35858661 |
| 67 | Hypoplasia of the thymus (HP:0000778) | 2.35388539 |
| 68 | Epistaxis (HP:0000421) | 2.32947124 |
| 69 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.30752990 |
| 70 | Lymphopenia (HP:0001888) | 2.29384457 |
| 71 | Oral leukoplakia (HP:0002745) | 2.28924605 |
| 72 | Abnormality of male internal genitalia (HP:0000022) | 2.27858896 |
| 73 | Recurrent sinusitis (HP:0011108) | 2.27795688 |
| 74 | Dicarboxylic aciduria (HP:0003215) | 2.27784881 |
| 75 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.27784881 |
| 76 | Thyroiditis (HP:0100646) | 2.25672395 |
| 77 | Myelodysplasia (HP:0002863) | 2.25395292 |
| 78 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.25352986 |
| 79 | Microvesicular hepatic steatosis (HP:0001414) | 2.23466427 |
| 80 | Gingival bleeding (HP:0000225) | 2.23045440 |
| 81 | Hepatosplenomegaly (HP:0001433) | 2.21584608 |
| 82 | Viral hepatitis (HP:0006562) | 2.20286996 |
| 83 | Abnormal platelet function (HP:0011869) | 2.19894683 |
| 84 | Impaired platelet aggregation (HP:0003540) | 2.19894683 |
| 85 | Granulocytopenia (HP:0001913) | 2.19442402 |
| 86 | Thoracic kyphosis (HP:0002942) | 2.18299529 |
| 87 | Gastrointestinal stroma tumor (HP:0100723) | 2.18031676 |
| 88 | Chronic sinusitis (HP:0011109) | 2.17783896 |
| 89 | Verrucae (HP:0200043) | 2.17052870 |
| 90 | Papilloma (HP:0012740) | 2.17052870 |
| 91 | Pallor (HP:0000980) | 2.16313187 |
| 92 | Skin rash (HP:0000988) | 2.16118656 |
| 93 | Increased cerebral lipofuscin (HP:0011813) | 2.14988487 |
| 94 | Bone marrow hypocellularity (HP:0005528) | 2.13895062 |
| 95 | Recurrent pneumonia (HP:0006532) | 2.13894319 |
| 96 | Poikiloderma (HP:0001029) | 2.13826579 |
| 97 | Eosinophilia (HP:0001880) | 2.13797287 |
| 98 | Increased muscle lipid content (HP:0009058) | 2.13531392 |
| 99 | Recurrent lower respiratory tract infections (HP:0002783) | 2.12153835 |
| 100 | Orchitis (HP:0100796) | 2.11204538 |
| 101 | Acute myeloid leukemia (HP:0004808) | 2.11153245 |
| 102 | Increased intramyocellular lipid droplets (HP:0012240) | 2.10768066 |
| 103 | Sepsis (HP:0100806) | 2.10651397 |
| 104 | Birth length less than 3rd percentile (HP:0003561) | 2.10267048 |
| 105 | Abnormality of DNA repair (HP:0003254) | 2.10139185 |
| 106 | Pulmonary infiltrates (HP:0002113) | 2.09973372 |
| 107 | Pustule (HP:0200039) | 2.08398279 |
| 108 | Fatigue (HP:0012378) | 2.08161290 |
| 109 | Severe visual impairment (HP:0001141) | 2.07954175 |
| 110 | Abnormality of macrophages (HP:0004311) | 2.07249759 |
| 111 | Prostate neoplasm (HP:0100787) | 2.06591327 |
| 112 | Acute hepatic failure (HP:0006554) | 2.05700599 |
| 113 | Hepatocellular necrosis (HP:0001404) | 2.04835569 |
| 114 | Ragged-red muscle fibers (HP:0003200) | 2.04519247 |
| 115 | Retrobulbar optic neuritis (HP:0100654) | 2.03809094 |
| 116 | Optic neuritis (HP:0100653) | 2.03809094 |
| 117 | Albinism (HP:0001022) | 2.03018671 |
| 118 | Clubbing of toes (HP:0100760) | 2.02928931 |
| 119 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.01911783 |
| 120 | Cerebral palsy (HP:0100021) | 2.01609163 |
| 121 | Keratoconjunctivitis sicca (HP:0001097) | 2.00600703 |
| 122 | Amyloidosis (HP:0011034) | 1.99472629 |
| 123 | Leukopenia (HP:0001882) | 1.96635173 |
| 124 | Hemoptysis (HP:0002105) | 1.95133472 |
| 125 | Leukocytosis (HP:0001974) | 1.94773281 |
| 126 | Pancytopenia (HP:0001876) | 1.94492044 |
| 127 | Abnormality of the pleura (HP:0002103) | 1.93382584 |
| 128 | Pulmonary fibrosis (HP:0002206) | 1.93108873 |
| 129 | Abnormality of lateral ventricle (HP:0030047) | 1.93059419 |
| 130 | Skin ulcer (HP:0200042) | 1.92567086 |
| 131 | Basal ganglia calcification (HP:0002135) | 1.89814851 |
| 132 | Abnormality of the fingertips (HP:0001211) | 1.88155145 |
| 133 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.87568422 |
| 134 | Spontaneous hematomas (HP:0007420) | 1.87264058 |
| 135 | Hepatic necrosis (HP:0002605) | 1.86997906 |
| 136 | Purpura (HP:0000979) | 1.86696266 |
| 137 | Macrocytic anemia (HP:0001972) | 1.86183888 |
| 138 | Erythema (HP:0010783) | 1.85779187 |
| 139 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.85345667 |
| 140 | Hypertensive crisis (HP:0100735) | 1.84686449 |
| 141 | Keratoconjunctivitis (HP:0001096) | 1.84219966 |
| 142 | Amaurosis fugax (HP:0100576) | 1.84107841 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TESK2 | 3.67257907 |
| 2 | VRK2 | 3.20335642 |
| 3 | KIT | 2.99668748 |
| 4 | STK16 | 2.96337279 |
| 5 | MAP4K1 | 2.93988756 |
| 6 | TEC | 2.84722430 |
| 7 | IRAK4 | 2.74559775 |
| 8 | KDR | 2.68954355 |
| 9 | TNIK | 2.55654084 |
| 10 | BTK | 2.52966055 |
| 11 | BLK | 2.40636213 |
| 12 | PIM2 | 2.23583841 |
| 13 | TAOK3 | 1.99300768 |
| 14 | MAP3K14 | 1.95733829 |
| 15 | EEF2K | 1.91008645 |
| 16 | CSF1R | 1.90182526 |
| 17 | FLT3 | 1.88332354 |
| 18 | MAP3K11 | 1.84360444 |
| 19 | EIF2AK3 | 1.77344948 |
| 20 | SYK | 1.76922893 |
| 21 | EIF2AK1 | 1.73245620 |
| 22 | WEE1 | 1.72076486 |
| 23 | VRK1 | 1.68460339 |
| 24 | NME2 | 1.65135281 |
| 25 | CLK1 | 1.60620997 |
| 26 | FES | 1.57666489 |
| 27 | MAP2K3 | 1.51427028 |
| 28 | CCNB1 | 1.49590502 |
| 29 | BMPR2 | 1.49067288 |
| 30 | IRAK3 | 1.46620366 |
| 31 | TYK2 | 1.41355879 |
| 32 | RIPK4 | 1.41195838 |
| 33 | MAP3K12 | 1.37339349 |
| 34 | MKNK2 | 1.35232020 |
| 35 | PIM1 | 1.35051514 |
| 36 | MKNK1 | 1.34365496 |
| 37 | GRK6 | 1.32267874 |
| 38 | TBK1 | 1.30482034 |
| 39 | SCYL2 | 1.29773043 |
| 40 | RPS6KB2 | 1.29629757 |
| 41 | JAK3 | 1.29440184 |
| 42 | BRSK2 | 1.26235526 |
| 43 | TXK | 1.24467623 |
| 44 | ZAP70 | 1.24259552 |
| 45 | SIK3 | 1.22307135 |
| 46 | CDC7 | 1.21757257 |
| 47 | LYN | 1.20638290 |
| 48 | MATK | 1.20465652 |
| 49 | MAP3K10 | 1.15082185 |
| 50 | NUAK1 | 1.14002629 |
| 51 | IKBKE | 1.12337271 |
| 52 | IKBKB | 1.11702328 |
| 53 | SRPK1 | 1.05330743 |
| 54 | DYRK3 | 1.05029943 |
| 55 | ITK | 1.04807442 |
| 56 | ATR | 1.04418569 |
| 57 | CDK19 | 1.03926913 |
| 58 | MAP3K6 | 1.03622203 |
| 59 | RPS6KA4 | 1.03340576 |
| 60 | ACVR1B | 0.98828565 |
| 61 | NEK2 | 0.98707514 |
| 62 | TLK1 | 0.97921376 |
| 63 | NLK | 0.94535977 |
| 64 | BUB1 | 0.93583579 |
| 65 | CDK8 | 0.92021715 |
| 66 | PRPF4B | 0.91919778 |
| 67 | STK10 | 0.91590220 |
| 68 | EIF2AK2 | 0.89839666 |
| 69 | MAPK4 | 0.88076088 |
| 70 | LCK | 0.84513865 |
| 71 | STK4 | 0.83777066 |
| 72 | TRPM7 | 0.83630655 |
| 73 | CDK4 | 0.83321062 |
| 74 | CDK12 | 0.82967497 |
| 75 | PASK | 0.82014016 |
| 76 | LRRK2 | 0.81766745 |
| 77 | MUSK | 0.79646631 |
| 78 | ARAF | 0.79005386 |
| 79 | RPS6KA6 | 0.78962163 |
| 80 | CDK7 | 0.76969969 |
| 81 | ERN1 | 0.76421564 |
| 82 | PRKCQ | 0.75794279 |
| 83 | MAP4K2 | 0.75717646 |
| 84 | TGFBR1 | 0.71567615 |
| 85 | YES1 | 0.71473350 |
| 86 | CDK6 | 0.68926739 |
| 87 | ZAK | 0.67608878 |
| 88 | TAOK2 | 0.67035495 |
| 89 | HIPK2 | 0.62908456 |
| 90 | MAPKAPK3 | 0.62706978 |
| 91 | RPS6KC1 | 0.62335417 |
| 92 | RPS6KL1 | 0.62335417 |
| 93 | AURKB | 0.60561831 |
| 94 | HCK | 0.58788610 |
| 95 | MAP3K5 | 0.58245443 |
| 96 | JAK2 | 0.56625404 |
| 97 | TESK1 | 0.55749615 |
| 98 | GRK7 | 0.53691801 |
| 99 | MAPK12 | 0.53499732 |
| 100 | BRSK1 | 0.49577077 |
| 101 | CSK | 0.49035511 |
| 102 | CHUK | 0.48864369 |
| 103 | RPS6KA5 | 0.48171734 |
| 104 | MAP3K13 | 0.47492223 |
| 105 | MAP2K6 | 0.47052773 |
| 106 | MAPK11 | 0.46186772 |
| 107 | PDK1 | 0.45876681 |
| 108 | PLK1 | 0.45552248 |
| 109 | BCKDK | 0.44315164 |
| 110 | ADRBK2 | 0.44240739 |
| 111 | MARK3 | 0.43885748 |
| 112 | DAPK1 | 0.43708698 |
| 113 | MAPKAPK5 | 0.42671488 |
| 114 | TSSK6 | 0.42224720 |
| 115 | RAF1 | 0.41612747 |
| 116 | MAP3K8 | 0.41512202 |
| 117 | ABL2 | 0.41467627 |
| 118 | TGFBR2 | 0.40661000 |
| 119 | TNK2 | 0.39495705 |
| 120 | NEK9 | 0.38388509 |
| 121 | PIK3CG | 0.37641087 |
| 122 | MAP2K2 | 0.36701556 |
| 123 | JAK1 | 0.36342551 |
| 124 | CDK9 | 0.35621531 |
| 125 | SIK2 | 0.35210256 |
| 126 | MAPK3 | 0.30188236 |
| 127 | RPS6KA1 | 0.28141435 |
| 128 | SMG1 | 0.28040449 |
| 129 | ABL1 | 0.26688675 |
| 130 | FYN | 0.26248003 |
| 131 | MAPKAPK2 | 0.25741074 |
| 132 | AURKA | 0.25220209 |
| 133 | PDPK1 | 0.24911813 |
| 134 | CSNK2A2 | 0.24860449 |
| 135 | CHEK2 | 0.23921225 |
| 136 | PRKD1 | 0.22624254 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.79361109 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.36563660 |
| 3 | Base excision repair_Homo sapiens_hsa03410 | 3.29421661 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.21425209 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.86287796 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.86272008 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.78381805 |
| 8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.37640668 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.30903747 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.08567847 |
| 11 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.07349915 |
| 12 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.01471189 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.91022702 |
| 14 | Leishmaniasis_Homo sapiens_hsa05140 | 1.89918209 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.87789541 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.86094525 |
| 17 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.83888023 |
| 18 | Proteasome_Homo sapiens_hsa03050 | 1.74160512 |
| 19 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.73989117 |
| 20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.73815405 |
| 21 | Asthma_Homo sapiens_hsa05310 | 1.67452060 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.60908733 |
| 23 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.56249253 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.55034871 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.49925641 |
| 26 | RNA polymerase_Homo sapiens_hsa03020 | 1.48604385 |
| 27 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.48480804 |
| 28 | Cell cycle_Homo sapiens_hsa04110 | 1.45531800 |
| 29 | Measles_Homo sapiens_hsa05162 | 1.45310711 |
| 30 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.44972506 |
| 31 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.42602518 |
| 32 | Protein export_Homo sapiens_hsa03060 | 1.41801606 |
| 33 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.35877768 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.34231123 |
| 35 | Other glycan degradation_Homo sapiens_hsa00511 | 1.29127474 |
| 36 | Legionellosis_Homo sapiens_hsa05134 | 1.25969046 |
| 37 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.23702736 |
| 38 | RNA degradation_Homo sapiens_hsa03018 | 1.22226774 |
| 39 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.22172352 |
| 40 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.22099141 |
| 41 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.15152524 |
| 42 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.14439766 |
| 43 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.13979369 |
| 44 | Pertussis_Homo sapiens_hsa05133 | 1.11644111 |
| 45 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.08303192 |
| 46 | Allograft rejection_Homo sapiens_hsa05330 | 1.07475559 |
| 47 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.06266417 |
| 48 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.04248748 |
| 49 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.02318511 |
| 50 | Influenza A_Homo sapiens_hsa05164 | 1.01744818 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.00585522 |
| 52 | RNA transport_Homo sapiens_hsa03013 | 0.98752593 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.97600585 |
| 54 | Parkinsons disease_Homo sapiens_hsa05012 | 0.96479092 |
| 55 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.95540657 |
| 56 | Basal transcription factors_Homo sapiens_hsa03022 | 0.93661757 |
| 57 | Shigellosis_Homo sapiens_hsa05131 | 0.93604016 |
| 58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.92178650 |
| 59 | Hepatitis B_Homo sapiens_hsa05161 | 0.91306737 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.90910220 |
| 61 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.90551238 |
| 62 | Purine metabolism_Homo sapiens_hsa00230 | 0.90399086 |
| 63 | Apoptosis_Homo sapiens_hsa04210 | 0.90076286 |
| 64 | Tuberculosis_Homo sapiens_hsa05152 | 0.89759614 |
| 65 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.87888018 |
| 66 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.87685495 |
| 67 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.87150524 |
| 68 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.82150748 |
| 69 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.81674173 |
| 70 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.80303922 |
| 71 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.79520114 |
| 72 | Peroxisome_Homo sapiens_hsa04146 | 0.75362616 |
| 73 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.72175279 |
| 74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.71302570 |
| 75 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.70353622 |
| 76 | Malaria_Homo sapiens_hsa05144 | 0.67822814 |
| 77 | Phagosome_Homo sapiens_hsa04145 | 0.66422224 |
| 78 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.65651580 |
| 79 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.65406429 |
| 80 | Platelet activation_Homo sapiens_hsa04611 | 0.65174162 |
| 81 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.64500235 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.62640108 |
| 83 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.61446189 |
| 84 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61056753 |
| 85 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.60965233 |
| 86 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.60775453 |
| 87 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.55137754 |
| 88 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.54654482 |
| 89 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.54037097 |
| 90 | HTLV-I infection_Homo sapiens_hsa05166 | 0.52633248 |
| 91 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.52396006 |
| 92 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51568332 |
| 93 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.51497111 |
| 94 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.50844083 |
| 95 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.49987208 |
| 96 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.49664587 |
| 97 | Salmonella infection_Homo sapiens_hsa05132 | 0.49114050 |
| 98 | Thyroid cancer_Homo sapiens_hsa05216 | 0.46224813 |
| 99 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.45121181 |
| 100 | Sulfur relay system_Homo sapiens_hsa04122 | 0.44937061 |
| 101 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.41847247 |
| 102 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.41109415 |
| 103 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.40083201 |
| 104 | Huntingtons disease_Homo sapiens_hsa05016 | 0.39859584 |
| 105 | Viral myocarditis_Homo sapiens_hsa05416 | 0.39446567 |
| 106 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.35849211 |
| 107 | Alzheimers disease_Homo sapiens_hsa05010 | 0.35808825 |
| 108 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.34498216 |
| 109 | Hepatitis C_Homo sapiens_hsa05160 | 0.33422218 |
| 110 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.33389250 |
| 111 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.32361753 |
| 112 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.31963905 |
| 113 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.30922872 |
| 114 | Colorectal cancer_Homo sapiens_hsa05210 | 0.29698041 |
| 115 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.29147636 |
| 116 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.28733454 |
| 117 | Lysosome_Homo sapiens_hsa04142 | 0.25940237 |
| 118 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.22911607 |
| 119 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.19340376 |
| 120 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13726794 |
| 121 | Alcoholism_Homo sapiens_hsa05034 | 0.12192995 |

