SPOCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.40099679
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16509903
3locomotory exploration behavior (GO:0035641)5.80326387
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75434879
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34667792
6negative regulation of cell killing (GO:0031342)5.34667792
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20849651
8regulation of synaptic vesicle exocytosis (GO:2000300)5.12094518
9synaptic vesicle exocytosis (GO:0016079)4.97313444
10glutamate secretion (GO:0014047)4.92577935
11vocalization behavior (GO:0071625)4.92070526
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.91634473
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58892816
14cellular potassium ion homeostasis (GO:0030007)4.57853092
15negative T cell selection (GO:0043383)4.53903912
16sodium ion export (GO:0071436)4.51658550
17neurotransmitter secretion (GO:0007269)4.51276496
18negative thymic T cell selection (GO:0045060)4.50905647
19regulation of synaptic vesicle transport (GO:1902803)4.49421223
20neuronal action potential propagation (GO:0019227)4.47073444
21positive regulation of gamma-delta T cell activation (GO:0046645)4.46876885
22layer formation in cerebral cortex (GO:0021819)4.36781949
23regulation of glutamate receptor signaling pathway (GO:1900449)4.33245694
24positive T cell selection (GO:0043368)4.25450874
25positive thymic T cell selection (GO:0045059)4.25020770
26gamma-aminobutyric acid transport (GO:0015812)4.22696305
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21175691
28exploration behavior (GO:0035640)4.20188356
29regulation of neuronal synaptic plasticity (GO:0048168)4.15701056
30proline transport (GO:0015824)4.14791767
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.14722355
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13078637
33thymic T cell selection (GO:0045061)4.12526724
34tolerance induction (GO:0002507)4.09081850
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06008119
36regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03576336
37protein localization to synapse (GO:0035418)4.00424670
38regulation of synapse structural plasticity (GO:0051823)3.97509496
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96751823
40neuromuscular process controlling posture (GO:0050884)3.90067920
41cerebellar Purkinje cell differentiation (GO:0021702)3.85984187
42cerebellar granule cell differentiation (GO:0021707)3.85758100
43T cell selection (GO:0045058)3.84633992
44activation of protein kinase A activity (GO:0034199)3.83597176
45response to interleukin-15 (GO:0070672)3.82790143
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82233887
47glycine transport (GO:0015816)3.80731862
48synaptic transmission, glutamatergic (GO:0035249)3.77983847
49regulation of gamma-delta T cell differentiation (GO:0045586)3.73690428
50antigen processing and presentation of endogenous antigen (GO:0019883)3.71056594
51neuron cell-cell adhesion (GO:0007158)3.70085201
52neuromuscular process controlling balance (GO:0050885)3.69106680
53L-amino acid import (GO:0043092)3.68408786
54positive regulation of Rap GTPase activity (GO:0032854)3.68141488
55cell communication by electrical coupling (GO:0010644)3.68072268
56activated T cell proliferation (GO:0050798)3.65890272
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65379751
58neurotransmitter transport (GO:0006836)3.61734645
59dendritic spine morphogenesis (GO:0060997)3.61037959
60signal complex assembly (GO:0007172)3.60439498
61glutamate receptor signaling pathway (GO:0007215)3.58205798
62long-term memory (GO:0007616)3.57189052
63regulation of B cell receptor signaling pathway (GO:0050855)3.54730360
64neuron-neuron synaptic transmission (GO:0007270)3.50447982
65membrane depolarization during action potential (GO:0086010)3.49100270
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.48804198
67positive regulation of membrane potential (GO:0045838)3.48121566
68cellular response to interleukin-15 (GO:0071350)3.45905913
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45867789
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45771483
71regulation of gamma-delta T cell activation (GO:0046643)3.45545311
72potassium ion import (GO:0010107)3.44673566
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44637503
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44169279
75leukocyte aggregation (GO:0070486)3.40910130
76neurotransmitter-gated ion channel clustering (GO:0072578)3.39460202
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32912347
78regulation of ARF protein signal transduction (GO:0032012)3.32560652
79regulation of neurotransmitter levels (GO:0001505)3.32510584
80regulation of neurotransmitter secretion (GO:0046928)3.30385359
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29664621
82potassium ion homeostasis (GO:0055075)3.29389340
83regulation of Rap GTPase activity (GO:0032317)3.28650895
84transmission of nerve impulse (GO:0019226)3.28582998
85vesicle transport along microtubule (GO:0047496)3.26950604
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24154142
87response to auditory stimulus (GO:0010996)3.21924973
88regulation of postsynaptic membrane potential (GO:0060078)3.21385138
89synaptic vesicle endocytosis (GO:0048488)3.21351645
90regulation of synaptic plasticity (GO:0048167)3.20985668
91chemosensory behavior (GO:0007635)3.16784416
92dendrite morphogenesis (GO:0048813)3.16500411
93auditory behavior (GO:0031223)3.15656764
94positive regulation of synapse maturation (GO:0090129)3.15469527
95prepulse inhibition (GO:0060134)3.14979003
96neuronal ion channel clustering (GO:0045161)3.14715363
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.13901190
98negative regulation of erythrocyte differentiation (GO:0045647)3.12970373
99cellular sodium ion homeostasis (GO:0006883)3.11150029
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10380360
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.10250992
102membrane hyperpolarization (GO:0060081)3.09591747
103innervation (GO:0060384)3.09523142
104T cell migration (GO:0072678)3.08421544
105regulation of neurotransmitter transport (GO:0051588)3.06159496
106axon cargo transport (GO:0008088)3.04838687
107membrane repolarization (GO:0086009)3.04387953
108positive regulation of potassium ion transmembrane transport (GO:1901381)3.04283415
109cerebellar Purkinje cell layer development (GO:0021680)3.02428183
110neuromuscular process (GO:0050905)3.00747469
111regulation of synaptic transmission, glutamatergic (GO:0051966)3.00399085
112membrane depolarization (GO:0051899)3.00197158
113regulation of vesicle fusion (GO:0031338)3.00099211
114regulation of isotype switching to IgG isotypes (GO:0048302)2.98808995
115negative regulation of T cell mediated immunity (GO:0002710)2.95921693
116positive regulation of neurotransmitter transport (GO:0051590)2.94389927
117negative regulation of leukocyte mediated immunity (GO:0002704)2.94249715
118regulation of T cell tolerance induction (GO:0002664)2.94122854
119regulation of dendritic spine morphogenesis (GO:0061001)2.93948538
120neuron recognition (GO:0008038)2.93905912
121mating behavior (GO:0007617)2.92734610
122amino acid import (GO:0043090)2.91100433
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88175608
124positive regulation of potassium ion transport (GO:0043268)2.87826600
125regulation of calcium ion-dependent exocytosis (GO:0017158)2.87652373
126organelle transport along microtubule (GO:0072384)2.85706015
127long-term synaptic potentiation (GO:0060291)2.85564738
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84776791
129cell communication involved in cardiac conduction (GO:0086065)2.84685147
130gamma-aminobutyric acid signaling pathway (GO:0007214)2.83819647
131response to pheromone (GO:0019236)2.83094716
132positive regulation of neurotransmitter secretion (GO:0001956)2.82298411
133axonal fasciculation (GO:0007413)2.78732898
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78260550
135alanine transport (GO:0032328)2.78088308
136cell migration in hindbrain (GO:0021535)2.77124718
137B cell receptor signaling pathway (GO:0050853)2.70752761
138regulation of beta-amyloid formation (GO:1902003)2.67890276
139regulation of voltage-gated calcium channel activity (GO:1901385)2.64907047
140T cell receptor signaling pathway (GO:0050852)2.63480602
141negative regulation of type 2 immune response (GO:0002829)2.63095087
142cell differentiation in hindbrain (GO:0021533)2.62381829
143regulation of defense response to virus by virus (GO:0050690)2.58810269
144regulation of synapse maturation (GO:0090128)2.58778083
145antigen receptor-mediated signaling pathway (GO:0050851)2.51391432
146regulation of ARF GTPase activity (GO:0032312)2.50363819
147axon ensheathment in central nervous system (GO:0032291)2.49744983
148central nervous system myelination (GO:0022010)2.49744983
149regulation of amyloid precursor protein catabolic process (GO:1902991)2.48442603
150regulation of tolerance induction (GO:0002643)2.46213855
151regulation of T-helper 2 cell differentiation (GO:0045628)2.45107089
152response to muramyl dipeptide (GO:0032495)2.43216337
153positive regulation of CREB transcription factor activity (GO:0032793)2.42786987
154regulation of regulatory T cell differentiation (GO:0045589)2.41713050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44646719
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.29315471
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55366155
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93672188
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93098566
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85651159
7RUNX_20019798_ChIP-Seq_JUKART_Human2.78859113
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.78744032
9GBX2_23144817_ChIP-Seq_PC3_Human2.77131724
10DROSHA_22980978_ChIP-Seq_HELA_Human2.76401905
11REST_21632747_ChIP-Seq_MESCs_Mouse2.73770386
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69710563
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69710563
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.61965910
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55899267
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53640005
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53182045
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40259272
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39314785
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36459066
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35089045
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.27750384
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.27114129
24* KDM2B_26808549_Chip-Seq_DND41_Human2.25514191
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24508659
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21674977
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21610134
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21282690
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16503752
30* RNF2_27304074_Chip-Seq_ESCs_Mouse2.14701260
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.12012606
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.11712460
33TCF7_22412390_ChIP-Seq_EML_Mouse2.07525898
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95808578
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95735325
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92136123
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90473604
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.90059916
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88568676
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83958966
41MYC_22102868_ChIP-Seq_BL_Human1.83443333
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80868977
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79759528
44MAF_26560356_Chip-Seq_TH1_Human1.78076463
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76850525
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.76079407
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76025081
48LXR_22292898_ChIP-Seq_THP-1_Human1.66531166
49UTX_26944678_Chip-Seq_JUKART_Human1.65584684
50MAF_26560356_Chip-Seq_TH2_Human1.55782713
51* MYB_26560356_Chip-Seq_TH2_Human1.55388971
52AR_21572438_ChIP-Seq_LNCaP_Human1.52871670
53VDR_21846776_ChIP-Seq_THP-1_Human1.52707640
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52278551
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48602993
56KDM2B_26808549_Chip-Seq_K562_Human1.48421102
57SCL_19346495_ChIP-Seq_HPC-7_Human1.47595627
58SMAD4_21799915_ChIP-Seq_A2780_Human1.44902606
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42232597
60* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41428066
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.41344903
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40871834
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38615503
64ZNF274_21170338_ChIP-Seq_K562_Hela1.36069499
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.35804579
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34862791
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.34175665
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32256328
69SPI1_23127762_ChIP-Seq_K562_Human1.32148441
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31668404
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31657630
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31568781
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30812866
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30058076
75AR_19668381_ChIP-Seq_PC3_Human1.27748774
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26123203
77VDR_24763502_ChIP-Seq_THP-1_Human1.25869328
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.25749670
79MYB_26560356_Chip-Seq_TH1_Human1.25153448
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22450763
81GATA3_27048872_Chip-Seq_THYMUS_Human1.22243224
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17690970
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.17616614
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17073295
85* STAT3_23295773_ChIP-Seq_U87_Human1.16923207
86* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16446660
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15439872
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14892566
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13490244
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13295338
91SMC4_20622854_ChIP-Seq_HELA_Human1.12533562
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11640244
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.11242409
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10499039
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09878278
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08941183
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08625702
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08393715
99GATA1_19941826_ChIP-Seq_K562_Human1.08290301
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03751688
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03692266
102AR_25329375_ChIP-Seq_VCAP_Human1.03601077
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03141778
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.03078366
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02837981
106OCT4_19829295_ChIP-Seq_ESCs_Human1.02758427
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02479967
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.02011011
109AHR_22903824_ChIP-Seq_MCF-7_Human1.01812402
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01664952
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.01077045
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.00101129
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99994569
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99743815
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.99691279
116* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99617134
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.99506108
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.99326505
119TCF4_23295773_ChIP-Seq_U87_Human0.98125837
120CTCF_27219007_Chip-Seq_Bcells_Human0.97574865
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97377144
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96592568
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96485059
124TAF15_26573619_Chip-Seq_HEK293_Human0.94648502
125P68_20966046_ChIP-Seq_HELA_Human0.94229640
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93903226
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93162825
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93155443
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92902592
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92398977
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91597648
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91593963
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90945422
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.90864482
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90798831
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90336915
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89987421
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.89862634
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89860670
140CREB1_26743006_Chip-Seq_LNCaP_Human0.88873536
141P300_19829295_ChIP-Seq_ESCs_Human0.88251561
142IGF1R_20145208_ChIP-Seq_DFB_Human0.87471197
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87251119
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86581915
145RXR_22108803_ChIP-Seq_LS180_Human0.86572114
146KLF4_19829295_ChIP-Seq_ESCs_Human0.86508665
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86201844
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85246225
149* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84877837
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84361585
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84236316
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.82239763
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80725051
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80674663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30491900
2MP0003635_abnormal_synaptic_transmissio4.01648722
3MP0003880_abnormal_central_pattern3.84552271
4MP0004270_analgesia3.81955625
5MP0003763_abnormal_thymus_physiology3.31492892
6MP0009046_muscle_twitch3.23758716
7MP0009745_abnormal_behavioral_response3.12943108
8MP0001968_abnormal_touch/_nociception3.11798132
9MP0002063_abnormal_learning/memory/cond3.04264729
10MP0002064_seizures2.98759442
11MP0005423_abnormal_somatic_nervous2.97889418
12MP0002734_abnormal_mechanical_nocicepti2.79176814
13MP0002272_abnormal_nervous_system2.65461743
14MP0002572_abnormal_emotion/affect_behav2.56330800
15MP0009780_abnormal_chondrocyte_physiolo2.44534367
16MP0003436_decreased_susceptibility_to2.43246397
17MP0002822_catalepsy2.42140367
18MP0001486_abnormal_startle_reflex2.41746851
19MP0002909_abnormal_adrenal_gland2.40853441
20MP0002735_abnormal_chemical_nociception2.39602274
21MP0004858_abnormal_nervous_system2.38313833
22MP0002736_abnormal_nociception_after2.30647263
23MP0002733_abnormal_thermal_nociception2.29145101
24MP0005671_abnormal_response_to2.15831737
25MP0001501_abnormal_sleep_pattern2.14080772
26MP0008569_lethality_at_weaning2.10841267
27MP0001970_abnormal_pain_threshold2.10069711
28MP0003724_increased_susceptibility_to2.01434288
29MP0001800_abnormal_humoral_immune1.97954238
30MP0001440_abnormal_grooming_behavior1.96891078
31MP0002067_abnormal_sensory_capabilities1.95101178
32MP0003329_amyloid_beta_deposits1.87896981
33MP0003879_abnormal_hair_cell1.87284494
34MP0003283_abnormal_digestive_organ1.86831350
35MP0004811_abnormal_neuron_physiology1.84813785
36MP0005000_abnormal_immune_tolerance1.81839506
37MP0003303_peritoneal_inflammation1.81376728
38MP0002184_abnormal_innervation1.80638714
39MP0003866_abnormal_defecation1.77303703
40MP0003300_gastrointestinal_ulcer1.68910743
41MP0000955_abnormal_spinal_cord1.67889265
42MP0002557_abnormal_social/conspecific_i1.66791845
43MP0004885_abnormal_endolymph1.65403662
44MP0001790_abnormal_immune_system1.64690697
45MP0005387_immune_system_phenotype1.64690697
46MP0002420_abnormal_adaptive_immunity1.62446659
47MP0005646_abnormal_pituitary_gland1.61332052
48MP0001819_abnormal_immune_cell1.58922702
49MP0002723_abnormal_immune_serum1.58534786
50MP0004924_abnormal_behavior1.56570958
51MP0005386_behavior/neurological_phenoty1.56570958
52MP0006276_abnormal_autonomic_nervous1.56544124
53MP0001835_abnormal_antigen_presentation1.49018237
54MP0000703_abnormal_thymus_morphology1.48796199
55MP0003633_abnormal_nervous_system1.48020560
56MP0005645_abnormal_hypothalamus_physiol1.47324638
57MP0001851_eye_inflammation1.45637880
58MP0000778_abnormal_nervous_system1.44684994
59MP0005025_abnormal_response_to1.43468359
60MP0004130_abnormal_muscle_cell1.40578080
61MP0002066_abnormal_motor_capabilities/c1.38833064
62MP0002882_abnormal_neuron_morphology1.38824450
63MP0003787_abnormal_imprinting1.38713703
64MP0002452_abnormal_antigen_presenting1.36958977
65MP0002398_abnormal_bone_marrow1.36140273
66MP0001984_abnormal_olfaction1.35332455
67MP0009333_abnormal_splenocyte_physiolog1.34720958
68MP0000685_abnormal_immune_system1.32962133
69MP0002419_abnormal_innate_immunity1.30086792
70MP0000716_abnormal_immune_system1.27812040
71MP0004145_abnormal_muscle_electrophysio1.26023200
72MP0003122_maternal_imprinting1.24915648
73MP0004947_skin_inflammation1.24719666
74MP0008961_abnormal_basal_metabolism1.23873856
75MP0000013_abnormal_adipose_tissue1.21219940
76MP0002405_respiratory_system_inflammati1.20036501
77MP0003631_nervous_system_phenotype1.19744444
78MP0000569_abnormal_digit_pigmentation1.17012025
79MP0001502_abnormal_circadian_rhythm1.16213765
80MP0006082_CNS_inflammation1.13620297
81MP0008260_abnormal_autophagy1.12222661
82MP0002229_neurodegeneration1.11454810
83MP0005167_abnormal_blood-brain_barrier1.08361569
84MP0010155_abnormal_intestine_physiology1.05429374
85MP0004381_abnormal_hair_follicle1.04659549
86MP0001873_stomach_inflammation1.04265167
87MP0004043_abnormal_pH_regulation1.04190677
88MP0004142_abnormal_muscle_tone1.03713147
89MP0003690_abnormal_glial_cell1.03527266
90MP0002152_abnormal_brain_morphology1.00100308
91MP0000465_gastrointestinal_hemorrhage0.99913468
92MP0002009_preneoplasia0.99042423
93MP0000751_myopathy0.98226936
94MP0002722_abnormal_immune_system0.98066405
95MP0003634_abnormal_glial_cell0.97519397
96MP0005166_decreased_susceptibility_to0.95674145
97MP0010386_abnormal_urinary_bladder0.94492832
98MP0003045_fibrosis0.94155300
99MP0002933_joint_inflammation0.93897162
100MP0000689_abnormal_spleen_morphology0.93412453
101MP0001533_abnormal_skeleton_physiology0.91876942
102MP0005310_abnormal_salivary_gland0.91694685
103MP0003632_abnormal_nervous_system0.89036192
104MP0002069_abnormal_eating/drinking_beha0.88999386
105MP0004742_abnormal_vestibular_system0.88854400
106MP0003075_altered_response_to0.88780419
107MP0008872_abnormal_physiological_respon0.88223801
108MP0000920_abnormal_myelination0.87515596
109MP0001177_atelectasis0.87478630
110MP0003172_abnormal_lysosome_physiology0.87123012
111MP0001299_abnormal_eye_distance/0.85931495
112MP0002429_abnormal_blood_cell0.85529182
113MP0008874_decreased_physiological_sensi0.83692766
114MP0004085_abnormal_heartbeat0.83086024
115MP0005464_abnormal_platelet_physiology0.82380995
116MP0005535_abnormal_body_temperature0.82060953
117MP0009785_altered_susceptibility_to0.80713720
118MP0009278_abnormal_bone_marrow0.79594406
119MP0005551_abnormal_eye_electrophysiolog0.79502531
120MP0002998_abnormal_bone_remodeling0.78203954
121MP0000604_amyloidosis0.78061913
122MP0002148_abnormal_hypersensitivity_rea0.77926839
123MP0003191_abnormal_cellular_cholesterol0.77327448
124MP0002133_abnormal_respiratory_system0.76766106
125MP0005388_respiratory_system_phenotype0.76766106
126MP0001485_abnormal_pinna_reflex0.76673010
127MP0005623_abnormal_meninges_morphology0.75766365
128MP0004233_abnormal_muscle_weight0.71586489
129MP0001963_abnormal_hearing_physiology0.70705976
130MP0000631_abnormal_neuroendocrine_gland0.70057235
131MP0001905_abnormal_dopamine_level0.68819625
132MP0010234_abnormal_vibrissa_follicle0.68109729
133MP0002090_abnormal_vision0.66646525
134MP0002752_abnormal_somatic_nervous0.65432443
135MP0002638_abnormal_pupillary_reflex0.65200930
136MP0001986_abnormal_taste_sensitivity0.62827533
137MP0005499_abnormal_olfactory_system0.61556120
138MP0005394_taste/olfaction_phenotype0.61556120
139MP0001348_abnormal_lacrimal_gland0.59652679
140MP0005187_abnormal_penis_morphology0.58811402
141MP0003137_abnormal_impulse_conducting0.57248688
142MP0004215_abnormal_myocardial_fiber0.57196034
143MP0003183_abnormal_peptide_metabolism0.56410980
144MP0001664_abnormal_digestion0.56112317
145MP0000747_muscle_weakness0.55612216
146MP0001943_abnormal_respiration0.54492979
147MP0001529_abnormal_vocalization0.54115257
148MP0006072_abnormal_retinal_apoptosis0.52111732
149MP0004510_myositis0.51974956

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.54901864
2Focal motor seizures (HP:0011153)6.20676133
3Focal seizures (HP:0007359)5.21424396
4Visual hallucinations (HP:0002367)5.19096119
5Action tremor (HP:0002345)4.91278331
6Obstructive sleep apnea (HP:0002870)4.46708421
7Eczematoid dermatitis (HP:0000976)4.37187165
8Progressive cerebellar ataxia (HP:0002073)4.33815066
9Ankle clonus (HP:0011448)4.05877198
10Atonic seizures (HP:0010819)4.02928549
11Supranuclear gaze palsy (HP:0000605)3.99957035
12Epileptic encephalopathy (HP:0200134)3.82315435
13Febrile seizures (HP:0002373)3.74199993
14Absence seizures (HP:0002121)3.70159955
15Generalized tonic-clonic seizures (HP:0002069)3.61439629
16Papilledema (HP:0001085)3.45868619
17Depression (HP:0000716)3.42586199
18T lymphocytopenia (HP:0005403)3.29764827
19Dialeptic seizures (HP:0011146)3.27246628
20Ventricular fibrillation (HP:0001663)3.18569175
21Abnormality of the lower motor neuron (HP:0002366)3.14291445
22Postural instability (HP:0002172)3.13058223
23Gaze-evoked nystagmus (HP:0000640)3.12463434
24Truncal ataxia (HP:0002078)3.07692192
25Stomatitis (HP:0010280)3.07364476
26Urinary bladder sphincter dysfunction (HP:0002839)3.07171058
27Poor eye contact (HP:0000817)3.04750756
28Impaired vibration sensation in the lower limbs (HP:0002166)3.03640335
29Dysdiadochokinesis (HP:0002075)3.00529124
30Hemiplegia (HP:0002301)2.94048531
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92948544
32Myositis (HP:0100614)2.92421975
33Abnormality of T cell number (HP:0011839)2.91592461
34Slow saccadic eye movements (HP:0000514)2.91021535
35Anxiety (HP:0000739)2.90498508
36Dysmetria (HP:0001310)2.89536628
37Elevated erythrocyte sedimentation rate (HP:0003565)2.88297300
38Mutism (HP:0002300)2.87148301
39Abnormal social behavior (HP:0012433)2.85600080
40Impaired social interactions (HP:0000735)2.85600080
41Impaired smooth pursuit (HP:0007772)2.84593742
42Peripheral hypomyelination (HP:0007182)2.81982042
43Insomnia (HP:0100785)2.81914572
44Genetic anticipation (HP:0003743)2.80406626
45Pustule (HP:0200039)2.74687528
46Intention tremor (HP:0002080)2.74083610
47Abnormal eating behavior (HP:0100738)2.72797649
48Spastic gait (HP:0002064)2.69304106
49Broad-based gait (HP:0002136)2.65743117
50Urinary urgency (HP:0000012)2.64215476
51Pheochromocytoma (HP:0002666)2.61200098
52Torticollis (HP:0000473)2.59224583
53Hemiparesis (HP:0001269)2.55892682
54Agitation (HP:0000713)2.54865844
55Scanning speech (HP:0002168)2.53868421
56Insidious onset (HP:0003587)2.52885992
57Termporal pattern (HP:0011008)2.52885992
58Annular pancreas (HP:0001734)2.51950382
59Abnormality of ocular smooth pursuit (HP:0000617)2.51851740
60Panhypogammaglobulinemia (HP:0003139)2.49529973
61Dysmetric saccades (HP:0000641)2.46972954
62Recurrent bacterial skin infections (HP:0005406)2.45754145
63Retrobulbar optic neuritis (HP:0100654)2.44861042
64Optic neuritis (HP:0100653)2.44861042
65Meningitis (HP:0001287)2.44724953
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.44627275
67Recurrent fungal infections (HP:0002841)2.40373648
68Orchitis (HP:0100796)2.39950756
69Mediastinal lymphadenopathy (HP:0100721)2.39398925
70Recurrent abscess formation (HP:0002722)2.37626869
71Pointed chin (HP:0000307)2.37495417
72Megalencephaly (HP:0001355)2.37231115
73Clonus (HP:0002169)2.36134700
74Increased IgE level (HP:0003212)2.35856669
75Bradykinesia (HP:0002067)2.35560546
76Bundle branch block (HP:0011710)2.33722370
77Sleep apnea (HP:0010535)2.30659076
78Abnormality of the fingertips (HP:0001211)2.29634054
79Diplopia (HP:0000651)2.29305624
80Abnormality of binocular vision (HP:0011514)2.29305624
81Gastrointestinal infarctions (HP:0005244)2.29187400
82Amblyopia (HP:0000646)2.29021601
83Focal dystonia (HP:0004373)2.28958385
84Postural tremor (HP:0002174)2.28589170
85Cellulitis (HP:0100658)2.26607531
86Lower limb muscle weakness (HP:0007340)2.26234531
87Neurofibrillary tangles (HP:0002185)2.25561874
88Agammaglobulinemia (HP:0004432)2.24396688
89Papilloma (HP:0012740)2.23553493
90Verrucae (HP:0200043)2.23553493
91EEG with generalized epileptiform discharges (HP:0011198)2.21927265
92Epileptiform EEG discharges (HP:0011182)2.20342502
93Spontaneous hematomas (HP:0007420)2.18101829
94Vasculitis (HP:0002633)2.16202466
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16089637
96Hypsarrhythmia (HP:0002521)2.15687964
97Severe combined immunodeficiency (HP:0004430)2.14798226
98Stereotypic behavior (HP:0000733)2.14759615
99Lower limb asymmetry (HP:0100559)2.14255820
100Abnormality of the corticospinal tract (HP:0002492)2.14014270
101Cerebral inclusion bodies (HP:0100314)2.13043607
102Neuroendocrine neoplasm (HP:0100634)2.12459927
103Ocular albinism (HP:0001107)2.11620430
104Abnormality of T cells (HP:0002843)2.11614597
105Progressive inability to walk (HP:0002505)2.11490270
106Abnormality of macrophages (HP:0004311)2.11259709
107Status epilepticus (HP:0002133)2.10725543
108Interstitial pulmonary disease (HP:0006530)2.10472489
109Neuronal loss in central nervous system (HP:0002529)2.10095783
110Craniofacial dystonia (HP:0012179)2.06393836
111Drooling (HP:0002307)2.06115093
112Excessive salivation (HP:0003781)2.06115093
113Hypercortisolism (HP:0001578)2.05383298
114Obstructive lung disease (HP:0006536)2.02717185
115Chronic obstructive pulmonary disease (HP:0006510)2.02717185
116Hyperacusis (HP:0010780)2.00189998
117Impaired vibratory sensation (HP:0002495)2.00067039
118Neoplasm of the heart (HP:0100544)1.99057696
119Recurrent bronchitis (HP:0002837)1.96035179
120Hypoventilation (HP:0002791)1.95436706
121Tetraplegia (HP:0002445)1.94595786
122Gait ataxia (HP:0002066)1.93399974
123Abnormal EKG (HP:0003115)1.93094048
124Gastrointestinal inflammation (HP:0004386)1.92970306
125Pulmonary infiltrates (HP:0002113)1.92894218
126Ulnar claw (HP:0001178)1.92880439
127Abnormality of calcium-phosphate metabolism (HP:0100530)1.91173623
128Abnormality of saccadic eye movements (HP:0000570)1.90973436
129Memory impairment (HP:0002354)1.90534447
130Resting tremor (HP:0002322)1.90486620
131Macroorchidism (HP:0000053)1.90439427
132Inflammation of the large intestine (HP:0002037)1.90037602
133Iris hypopigmentation (HP:0007730)1.89785669
134Prolonged bleeding time (HP:0003010)1.89262679
135Lymphopenia (HP:0001888)1.88254039
136Growth hormone excess (HP:0000845)1.87062614
137Spinal canal stenosis (HP:0003416)1.86466078
138Failure to thrive in infancy (HP:0001531)1.85511687
139Encephalitis (HP:0002383)1.85485533
140Prolonged QT interval (HP:0001657)1.84656430
141Rapidly progressive (HP:0003678)1.84613967
142Recurrent gram-negative bacterial infections (HP:0005420)1.84511965
143IgM deficiency (HP:0002850)1.84066959
144Pulmonary embolism (HP:0002204)1.83611337
145Gastrointestinal stroma tumor (HP:0100723)1.82100124
146Neoplasm of the peripheral nervous system (HP:0100007)1.81737489
147Limb dystonia (HP:0002451)1.81678853
148Segmental peripheral demyelination/remyelination (HP:0003481)1.81613015
149Fetal akinesia sequence (HP:0001989)1.81441255
150Elfin facies (HP:0004428)1.81231378
151Chest pain (HP:0100749)1.79251444
152Hammertoe (HP:0001765)1.78664934
153Amyotrophic lateral sclerosis (HP:0007354)1.78587120
154Rigidity (HP:0002063)1.78394581
155Ankyloglossia (HP:0010296)1.76618963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.59059118
2MAP3K94.09306797
3MAP4K13.09538541
4EPHA43.05508083
5MAP3K42.86917139
6MINK12.84477792
7PRKD32.76584118
8MARK12.64504180
9PAK62.51581097
10NTRK12.47457685
11KSR22.41231720
12DAPK22.33668120
13CAMKK12.21114048
14TXK2.11869979
15NTRK22.08851824
16MAP2K71.99676671
17MAP3K21.79633148
18MAP2K41.77572267
19STK381.77057364
20LMTK21.61639151
21CDK51.53462801
22ITK1.49174697
23JAK11.47753569
24CAMKK21.45937945
25TYRO31.41494013
26SIK31.39587762
27RIPK41.39454813
28TYK21.37963034
29RIPK11.37903486
30GRK61.35960836
31MAP3K121.35345848
32MAPK121.35013108
33ZAP701.34411632
34UHMK11.32521732
35FGFR41.29597344
36PRKCH1.28163286
37LATS21.28096723
38GRK51.28035472
39SIK21.27795455
40WNK11.24758163
41RET1.23668248
42TAOK11.21461502
43PHKG11.21048186
44PHKG21.21048186
45ALK1.20364437
46KSR11.17414267
47SYK1.12463198
48PRKCG1.12113524
49EPHB11.11852311
50FGFR31.11361968
51DAPK11.08824899
52BTK1.08187104
53HCK1.04694152
54CSK1.04671042
55NLK1.04415522
56SGK4941.04190107
57SGK2231.04190107
58FES1.03886706
59TNIK1.03389394
60MAPK131.01449093
61MAP3K11.00966767
62STK110.97905178
63JAK20.96408616
64PNCK0.94481862
65CDC42BPA0.94398484
66CAMK10.93898626
67SCYL20.93747426
68SGK30.92985575
69BLK0.92087070
70LCK0.92057922
71ARAF0.89027925
72PINK10.88681529
73CDK190.88522194
74SGK20.87296720
75IKBKE0.87284385
76FGFR20.85657413
77PRPF4B0.85298551
78ERN10.84045237
79PAK30.81685963
80PLK20.80311505
81MAP3K110.80161290
82JAK30.79750397
83MARK20.78547562
84TAOK30.76327691
85MAP3K130.75303190
86CDK150.75271704
87CAMK2A0.74989846
88CDK140.74413501
89CDK180.74197464
90CAMK1G0.72948755
91TNK20.71706337
92PDK10.71433916
93PDPK10.68501722
94MAP3K100.66911199
95PDGFRA0.66814951
96PRKCQ0.64432214
97MAPK70.64250319
98CDK11A0.63706808
99SGK10.62632816
100FER0.61959385
101MAP3K140.59323535
102CSNK1G20.58458592
103IRAK40.58219928
104PASK0.57508739
105NEK10.56563959
106RPS6KA30.56476481
107SIK10.56444502
108CDK120.56287617
109TRIB30.55693991
110BMPR20.55457348
111DYRK1B0.54084399
112CAMK2B0.53417319
113BRSK10.52846411
114LYN0.52494806
115DYRK1A0.52427525
116MAPK100.51918016
117MAP2K30.50318926
118RPS6KA20.50150463
119HIPK20.49315835
120MAPK110.49037311
121CAMK40.48894561
122NEK60.47641988
123INSRR0.46841273
124FYN0.46808521
125PRKCZ0.46022015
126MARK30.45335794
127MAP3K70.45122980
128ICK0.43803491
129PTK2B0.43749321
130RAF10.43721918
131MAP2K10.42493176
132PRKD20.41782315
133CASK0.41490477
134WNK30.40809629
135EPHA30.40683828
136WNK40.40616490
137CAMK2G0.39839385
138PKN10.39497259
139TBK10.39170886
140CAMK2D0.38757291
141PRKCE0.38631616
142PTK20.34783167
143OXSR10.34751207
144PRKCB0.33347959

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.12596843
2Nicotine addiction_Homo sapiens_hsa050333.06756276
3GABAergic synapse_Homo sapiens_hsa047272.56358242
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.52534113
5Olfactory transduction_Homo sapiens_hsa047402.52435500
6Circadian entrainment_Homo sapiens_hsa047132.50214419
7Long-term potentiation_Homo sapiens_hsa047202.41428629
8Glutamatergic synapse_Homo sapiens_hsa047242.36121401
9Insulin secretion_Homo sapiens_hsa049112.31499942
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31109889
11Morphine addiction_Homo sapiens_hsa050322.25381317
12Amphetamine addiction_Homo sapiens_hsa050312.17405975
13Salivary secretion_Homo sapiens_hsa049702.08907115
14T cell receptor signaling pathway_Homo sapiens_hsa046602.00814273
15Dopaminergic synapse_Homo sapiens_hsa047281.99909784
16Gastric acid secretion_Homo sapiens_hsa049711.91836723
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88261698
18Cholinergic synapse_Homo sapiens_hsa047251.85486010
19Primary immunodeficiency_Homo sapiens_hsa053401.84669764
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77213520
21Taste transduction_Homo sapiens_hsa047421.75589343
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70281258
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65992177
24Type II diabetes mellitus_Homo sapiens_hsa049301.64700566
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63723685
26B cell receptor signaling pathway_Homo sapiens_hsa046621.60946254
27Cocaine addiction_Homo sapiens_hsa050301.60601637
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57750992
29Renin secretion_Homo sapiens_hsa049241.56800863
30Long-term depression_Homo sapiens_hsa047301.55117766
31Nitrogen metabolism_Homo sapiens_hsa009101.53446245
32Osteoclast differentiation_Homo sapiens_hsa043801.52004877
33Oxytocin signaling pathway_Homo sapiens_hsa049211.49174085
34GnRH signaling pathway_Homo sapiens_hsa049121.40189086
35Calcium signaling pathway_Homo sapiens_hsa040201.40093735
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38596389
37Serotonergic synapse_Homo sapiens_hsa047261.37872354
38Gap junction_Homo sapiens_hsa045401.31389647
39cAMP signaling pathway_Homo sapiens_hsa040241.29303048
40Estrogen signaling pathway_Homo sapiens_hsa049151.27942039
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27924441
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26713981
43Acute myeloid leukemia_Homo sapiens_hsa052211.19457064
44Dorso-ventral axis formation_Homo sapiens_hsa043201.15983078
45Glioma_Homo sapiens_hsa052141.13291644
46Pancreatic secretion_Homo sapiens_hsa049721.08227944
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07179756
48Autoimmune thyroid disease_Homo sapiens_hsa053201.06731507
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06292273
50Graft-versus-host disease_Homo sapiens_hsa053321.05617693
51Allograft rejection_Homo sapiens_hsa053301.02618852
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00797027
53Leishmaniasis_Homo sapiens_hsa051400.99564245
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98875188
55Melanogenesis_Homo sapiens_hsa049160.98660952
56Thyroid hormone synthesis_Homo sapiens_hsa049180.97580941
57ErbB signaling pathway_Homo sapiens_hsa040120.96079185
58Axon guidance_Homo sapiens_hsa043600.94367891
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.94010582
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.93630037
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87344348
62Measles_Homo sapiens_hsa051620.84744661
63Collecting duct acid secretion_Homo sapiens_hsa049660.84557772
64Tuberculosis_Homo sapiens_hsa051520.84519607
65Oocyte meiosis_Homo sapiens_hsa041140.84274624
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83465662
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83280083
68Colorectal cancer_Homo sapiens_hsa052100.83193785
69Platelet activation_Homo sapiens_hsa046110.82294110
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81078313
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79207502
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.79123036
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.77876610
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.77237651
75Chronic myeloid leukemia_Homo sapiens_hsa052200.74958255
76mTOR signaling pathway_Homo sapiens_hsa041500.74872460
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.74443104
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74152125
79Dilated cardiomyopathy_Homo sapiens_hsa054140.73929342
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73329318
81Bile secretion_Homo sapiens_hsa049760.73169217
82Vibrio cholerae infection_Homo sapiens_hsa051100.73063783
83Type I diabetes mellitus_Homo sapiens_hsa049400.71836681
84Pancreatic cancer_Homo sapiens_hsa052120.70850304
85Choline metabolism in cancer_Homo sapiens_hsa052310.70084660
86Cardiac muscle contraction_Homo sapiens_hsa042600.69397135
87MAPK signaling pathway_Homo sapiens_hsa040100.69280849
88FoxO signaling pathway_Homo sapiens_hsa040680.67060091
89Toxoplasmosis_Homo sapiens_hsa051450.66919287
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66360774
91VEGF signaling pathway_Homo sapiens_hsa043700.64664838
92Glucagon signaling pathway_Homo sapiens_hsa049220.64398047
93TNF signaling pathway_Homo sapiens_hsa046680.64326771
94Hepatitis B_Homo sapiens_hsa051610.63534196
95Endocytosis_Homo sapiens_hsa041440.62468208
96Viral myocarditis_Homo sapiens_hsa054160.61849253
97Inositol phosphate metabolism_Homo sapiens_hsa005620.61659101
98Hematopoietic cell lineage_Homo sapiens_hsa046400.60283022
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59870398
100Endometrial cancer_Homo sapiens_hsa052130.58938041
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58640922
102Rap1 signaling pathway_Homo sapiens_hsa040150.56884197
103HIF-1 signaling pathway_Homo sapiens_hsa040660.54895489
104Insulin signaling pathway_Homo sapiens_hsa049100.54527481
105Ras signaling pathway_Homo sapiens_hsa040140.54243820
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.54058564
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53686402
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53410401
109Phototransduction_Homo sapiens_hsa047440.53305371
110Circadian rhythm_Homo sapiens_hsa047100.51867062
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51839430
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49827684
113Prion diseases_Homo sapiens_hsa050200.49166452
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47953246
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47533225
116Ovarian steroidogenesis_Homo sapiens_hsa049130.46410360
117Non-small cell lung cancer_Homo sapiens_hsa052230.46312134
118Renal cell carcinoma_Homo sapiens_hsa052110.46135953
119Alcoholism_Homo sapiens_hsa050340.46100871
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44363959
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43573492
122Prolactin signaling pathway_Homo sapiens_hsa049170.42605887
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39788510
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38842969
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38354420
126Wnt signaling pathway_Homo sapiens_hsa043100.37662614
127Mineral absorption_Homo sapiens_hsa049780.37514771
128Chemokine signaling pathway_Homo sapiens_hsa040620.37112757
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.36464509
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.30356367
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29966308
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.28978619
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28864697

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