SPON1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron fate determination (GO:0048664)7.22451452
2radial glial cell differentiation (GO:0060019)6.59700727
3negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)6.32888204
4regulation of secondary heart field cardioblast proliferation (GO:0003266)6.23746998
5regulation of cardioblast proliferation (GO:0003264)6.23746998
6cell morphogenesis involved in neuron differentiation (GO:0048667)5.68571122
7nephron tubule morphogenesis (GO:0072078)5.33869177
8nephron epithelium morphogenesis (GO:0072088)5.33869177
9regulation of timing of cell differentiation (GO:0048505)5.28764046
10substrate-independent telencephalic tangential migration (GO:0021826)5.27264124
11substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.27264124
12central nervous system myelination (GO:0022010)5.19046031
13axon ensheathment in central nervous system (GO:0032291)5.19046031
14regulation of organ formation (GO:0003156)5.07521475
15negative regulation of glial cell proliferation (GO:0060253)5.05396038
16mating behavior (GO:0007617)5.04808829
17cerebellar granule cell differentiation (GO:0021707)5.01862913
18negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.90019751
19peristalsis (GO:0030432)4.89162402
20regulation of development, heterochronic (GO:0040034)4.87716593
21lens fiber cell development (GO:0070307)4.66848899
22innervation (GO:0060384)4.59478199
23establishment of nucleus localization (GO:0040023)4.56438605
24cochlea development (GO:0090102)4.54279492
25negative regulation of epidermal cell differentiation (GO:0045605)4.47749086
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.47608796
27stem cell development (GO:0048864)4.42187361
28cell proliferation in forebrain (GO:0021846)4.36749770
29positive regulation of BMP signaling pathway (GO:0030513)4.33726720
30negative regulation of glial cell differentiation (GO:0045686)4.32597775
31lateral sprouting from an epithelium (GO:0060601)4.32350993
32phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.30046971
33dopamine transport (GO:0015872)4.22228505
34cell-cell signaling involved in cell fate commitment (GO:0045168)4.19625639
35cranial nerve development (GO:0021545)4.16367002
36vocalization behavior (GO:0071625)4.14929817
37positive regulation of Notch signaling pathway (GO:0045747)4.03226801
38negative regulation of sodium ion transport (GO:0010766)3.97782393
39regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.97658356
40regulation of oligodendrocyte differentiation (GO:0048713)3.97096205
41forebrain neuron differentiation (GO:0021879)3.96386082
42tongue development (GO:0043586)3.95716831
43ventricular septum development (GO:0003281)3.94762859
44axon extension involved in axon guidance (GO:0048846)3.87744070
45neuron projection extension involved in neuron projection guidance (GO:1902284)3.87744070
46striatum development (GO:0021756)3.83995710
47phasic smooth muscle contraction (GO:0014821)3.79810534
48astrocyte development (GO:0014002)3.78728527
49positive regulation of vascular permeability (GO:0043117)3.77319719
50telencephalon development (GO:0021537)3.73037418
51maternal behavior (GO:0042711)3.72844509
52neural crest cell development (GO:0014032)3.71701197
53renal tubule morphogenesis (GO:0061333)3.70534309
54negative regulation of axon guidance (GO:1902668)3.67056109
55negative regulation of epidermis development (GO:0045683)3.66453931
56positive regulation of glial cell differentiation (GO:0045687)3.65620561
57prepulse inhibition (GO:0060134)3.61936550
58labyrinthine layer blood vessel development (GO:0060716)3.60223943
59neuron cell-cell adhesion (GO:0007158)3.59895339
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.59168938
61positive regulation of embryonic development (GO:0040019)3.58900307
62locomotory exploration behavior (GO:0035641)3.53680372
63regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.51462368
64regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.51462368
65glomerular filtration (GO:0003094)3.50381014
66glomerular basement membrane development (GO:0032836)3.47010407
67asymmetric protein localization (GO:0008105)3.45190533
68ventricular septum morphogenesis (GO:0060412)3.43240258
69transmission of nerve impulse (GO:0019226)3.42485510
70presynaptic membrane organization (GO:0097090)3.39405160
71regulation of axon guidance (GO:1902667)3.37826689
72somatic stem cell maintenance (GO:0035019)3.35452363
73cell proliferation involved in metanephros development (GO:0072203)3.35451152
74midbrain development (GO:0030901)3.33296685
75cell communication by electrical coupling (GO:0010644)3.32607749
76behavioral response to cocaine (GO:0048148)3.31916966
77dermatan sulfate biosynthetic process (GO:0030208)3.29243496
78regulation of axon extension involved in axon guidance (GO:0048841)3.29197130
79negative regulation of leukocyte chemotaxis (GO:0002689)3.29087287
80ionotropic glutamate receptor signaling pathway (GO:0035235)3.28283879
81negative regulation of axon extension (GO:0030517)3.26590566
82spermatid nucleus differentiation (GO:0007289)3.25122992
83parental behavior (GO:0060746)3.25036450
84regulation of fever generation (GO:0031620)3.24360903
85negative regulation of embryonic development (GO:0045992)3.22276088
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21923716
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18120947
88chondroitin sulfate catabolic process (GO:0030207)3.17012099
89regulation of heart morphogenesis (GO:2000826)3.15922376
90neuronal action potential (GO:0019228)3.14501551
91cardiac septum development (GO:0003279)3.14430532
92regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.14359233
93lung epithelium development (GO:0060428)3.11900292
94regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11730643
95regulation of neurotransmitter uptake (GO:0051580)3.11274855
96negative regulation of homotypic cell-cell adhesion (GO:0034111)3.09252418
97smooth muscle contraction (GO:0006939)3.09248377
98renal filtration (GO:0097205)3.08828714
99glutamate receptor signaling pathway (GO:0007215)3.07736957
100mesenchymal cell development (GO:0014031)3.07320323
101positive regulation of synapse assembly (GO:0051965)3.06663265
102sodium ion export (GO:0071436)3.06381377
103axonal fasciculation (GO:0007413)3.06083381
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04474937
105dendritic spine morphogenesis (GO:0060997)3.03405182
106outer ear morphogenesis (GO:0042473)3.03212108
107negative regulation of gliogenesis (GO:0014014)3.02738616
108cardiac muscle cell proliferation (GO:0060038)3.02104740
109negative chemotaxis (GO:0050919)3.00140637
110dermatan sulfate metabolic process (GO:0030205)2.99343458
111somatic stem cell division (GO:0048103)2.98904613
112endocardial cushion morphogenesis (GO:0003203)2.98328154
113heparan sulfate proteoglycan metabolic process (GO:0030201)2.96549944
114non-canonical Wnt signaling pathway (GO:0035567)2.96512241
115cellular potassium ion homeostasis (GO:0030007)2.95002736
116branching involved in salivary gland morphogenesis (GO:0060445)2.94877339
117glomerulus development (GO:0032835)2.94180596
118limb bud formation (GO:0060174)2.93862569
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91817287
120cell proliferation involved in kidney development (GO:0072111)2.91397237
121neuron recognition (GO:0008038)2.90697987
122postsynaptic membrane organization (GO:0001941)2.89409814
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87105280
124gamma-aminobutyric acid transport (GO:0015812)2.86432398
125regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86056706
126cellular sodium ion homeostasis (GO:0006883)2.85016272
127regulation of glutamate receptor signaling pathway (GO:1900449)2.81046994
128positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79508834
129regulation of synapse assembly (GO:0051963)2.79266669
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77366386
131peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77343090
132regulation of synapse structural plasticity (GO:0051823)2.76591819
133mesenchyme morphogenesis (GO:0072132)2.74973422
134somite development (GO:0061053)2.74752852
135heart valve formation (GO:0003188)2.74745622
136synaptic transmission, glutamatergic (GO:0035249)2.74192457
137exploration behavior (GO:0035640)2.73730646
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72520187
139chondrocyte development (GO:0002063)2.71775380
140sequestering of extracellular ligand from receptor (GO:0035581)2.70717774
141retinal ganglion cell axon guidance (GO:0031290)2.66632028
142establishment of planar polarity (GO:0001736)2.63852750
143establishment of tissue polarity (GO:0007164)2.63852750
144positive regulation of macrophage cytokine production (GO:0060907)2.63750674
145positive regulation of astrocyte differentiation (GO:0048711)2.61999368
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61639966
147mesenchymal-epithelial cell signaling (GO:0060638)2.60893327
148nucleus localization (GO:0051647)2.59762288
149response to auditory stimulus (GO:0010996)2.55320558
150negative regulation of oligodendrocyte differentiation (GO:0048715)2.54689672
151glutamate secretion (GO:0014047)2.54346985
152protein localization to synapse (GO:0035418)2.52601794
153regulation of neuronal synaptic plasticity (GO:0048168)2.49648524
154regulation of synapse organization (GO:0050807)2.48167717
155long-term synaptic potentiation (GO:0060291)2.46317418
156regulation of synaptic transmission, glutamatergic (GO:0051966)2.45377374
157synaptic vesicle exocytosis (GO:0016079)2.45070430
158epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.44548002
159neuronal action potential propagation (GO:0019227)2.44308405
160regulation of respiratory system process (GO:0044065)2.43661130
161regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.43610077
162regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43257421
163presynaptic membrane assembly (GO:0097105)2.41904873
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41450867
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.41222556
166regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41128410
167regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.41100466
168neuronal stem cell maintenance (GO:0097150)2.40389636
169artery development (GO:0060840)2.39092435
170regulation of astrocyte differentiation (GO:0048710)2.38702520
171positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.38046912
172negative regulation of smoothened signaling pathway (GO:0045879)2.37641887
173layer formation in cerebral cortex (GO:0021819)2.37504795
174cardiac epithelial to mesenchymal transition (GO:0060317)2.37413703
175neurotransmitter-gated ion channel clustering (GO:0072578)2.35733852
176mesenchymal cell proliferation (GO:0010463)2.35014797
177positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.34454318
178proline transport (GO:0015824)2.33749737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15194060
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.71951781
3GBX2_23144817_ChIP-Seq_PC3_Human3.24161937
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23149736
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07681468
6* EED_16625203_ChIP-ChIP_MESCs_Mouse3.05382826
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98009945
8* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.96178755
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88601701
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88601701
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.85928428
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84077499
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.72318972
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69391785
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38236566
16* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28250697
17* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.23171244
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.20607482
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12010920
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06435587
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04237131
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.04041553
23AR_21572438_ChIP-Seq_LNCaP_Human2.03492984
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96489553
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88260298
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85002444
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.78026950
28DROSHA_22980978_ChIP-Seq_HELA_Human1.77751160
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74570490
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73508296
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69786403
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65836281
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64751388
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.60302406
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59955573
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55058696
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54290447
38* EP300_21415370_ChIP-Seq_HL-1_Mouse1.52498977
39P300_19829295_ChIP-Seq_ESCs_Human1.51540693
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.46062415
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.45812849
42TBX3_20139965_ChIP-Seq_MESCs_Mouse1.43663576
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43544341
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42556680
45TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39516834
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37410047
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36895051
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35953530
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35420847
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34335392
51AHR_22903824_ChIP-Seq_MCF-7_Human1.31770931
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30775911
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.30592685
54* TP53_20018659_ChIP-ChIP_R1E_Mouse1.30358587
55TP53_18474530_ChIP-ChIP_U2OS_Human1.29810914
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.29081013
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.28515025
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27099410
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26808249
60* BCAT_22108803_ChIP-Seq_LS180_Human1.26046172
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25903526
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25512628
63AR_25329375_ChIP-Seq_VCAP_Human1.23473588
64* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23199129
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22557913
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21734706
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21612315
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.21487992
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21096991
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21071120
71ZNF274_21170338_ChIP-Seq_K562_Hela1.20705985
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20313970
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19114227
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18515634
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17104190
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15504158
77* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14974629
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.14813396
79* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14794471
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.14771893
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14586480
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14463260
83* AR_19668381_ChIP-Seq_PC3_Human1.14251606
84KDM2B_26808549_Chip-Seq_REH_Human1.13624303
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.12162397
86VDR_22108803_ChIP-Seq_LS180_Human1.11702173
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11236321
88TAF15_26573619_Chip-Seq_HEK293_Human1.10865698
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10390169
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09996364
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.09989460
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09521944
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.08407162
94* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08172567
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.07710508
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06830549
97STAT3_23295773_ChIP-Seq_U87_Human1.06572451
98EWS_26573619_Chip-Seq_HEK293_Human1.06379704
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04507669
100RUNX2_22187159_ChIP-Seq_PCA_Human1.03797476
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.03179122
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.01814501
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01400791
104FUS_26573619_Chip-Seq_HEK293_Human1.01312661
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00687904
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99052345
107* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97772485
108TP53_16413492_ChIP-PET_HCT116_Human0.97752140
109JUN_21703547_ChIP-Seq_K562_Human0.97666763
110RXR_22108803_ChIP-Seq_LS180_Human0.97432198
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95858077
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.94627123
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.94589048
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.93573413
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93540873
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93436480
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89983930
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88837398
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88837398
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87649356
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87649356
122* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87175413
123RNF2_27304074_Chip-Seq_NSC_Mouse0.85976122
124TCF4_23295773_ChIP-Seq_U87_Human0.85825133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.73358157
2MP0004859_abnormal_synaptic_plasticity3.39740636
3MP0005084_abnormal_gallbladder_morpholo3.27073888
4MP0003880_abnormal_central_pattern2.92638421
5MP0000467_abnormal_esophagus_morphology2.90040815
6MP0008438_abnormal_cutaneous_collagen2.73689976
7MP0004858_abnormal_nervous_system2.69157600
8MP0002928_abnormal_bile_duct2.68532432
9MP0003635_abnormal_synaptic_transmissio2.55187128
10MP0005503_abnormal_tendon_morphology2.53549886
11MP0001958_emphysema2.35112581
12MP0005423_abnormal_somatic_nervous2.29750514
13MP0003122_maternal_imprinting2.26657654
14MP0000778_abnormal_nervous_system2.19350931
15MP0000569_abnormal_digit_pigmentation2.16698618
16MP0002277_abnormal_respiratory_mucosa2.16125606
17MP0002063_abnormal_learning/memory/cond1.99684191
18MP0005171_absent_coat_pigmentation1.98880678
19MP0009745_abnormal_behavioral_response1.97175057
20MP0004272_abnormal_basement_membrane1.93845889
21MP0002064_seizures1.93382023
22MP0001968_abnormal_touch/_nociception1.92012413
23MP0002736_abnormal_nociception_after1.90103734
24MP0004270_analgesia1.88173343
25MP0003283_abnormal_digestive_organ1.87552749
26MP0004885_abnormal_endolymph1.81032383
27MP0002282_abnormal_trachea_morphology1.80264949
28MP0000383_abnormal_hair_follicle1.76593414
29MP0003011_delayed_dark_adaptation1.71598963
30MP0002572_abnormal_emotion/affect_behav1.69930222
31MP0009046_muscle_twitch1.68670525
32MP0000631_abnormal_neuroendocrine_gland1.68040631
33MP0001486_abnormal_startle_reflex1.62457943
34MP0001485_abnormal_pinna_reflex1.59312428
35MP0005174_abnormal_tail_pigmentation1.57385603
36MP0000751_myopathy1.57046934
37MP0002102_abnormal_ear_morphology1.56934937
38MP0002932_abnormal_joint_morphology1.56494289
39MP0002822_catalepsy1.53030924
40MP0002272_abnormal_nervous_system1.50919006
41MP0002837_dystrophic_cardiac_calcinosis1.48836684
42MP0003136_yellow_coat_color1.47930557
43MP0003941_abnormal_skin_development1.47656431
44MP0001299_abnormal_eye_distance/1.45971822
45MP0000566_synostosis1.44300465
46MP0000537_abnormal_urethra_morphology1.43681835
47MP0002067_abnormal_sensory_capabilities1.42480544
48MP0001286_abnormal_eye_development1.39373206
49MP0009780_abnormal_chondrocyte_physiolo1.38633404
50MP0001529_abnormal_vocalization1.38076735
51MP0001501_abnormal_sleep_pattern1.35602200
52MP0010030_abnormal_orbit_morphology1.33732906
53MP0001177_atelectasis1.31328235
54MP0002734_abnormal_mechanical_nocicepti1.30310546
55MP0009384_cardiac_valve_regurgitation1.29398915
56MP0001440_abnormal_grooming_behavior1.28585926
57MP0003115_abnormal_respiratory_system1.27098395
58MP0009250_abnormal_appendicular_skeleto1.26916676
59MP0003279_aneurysm1.25629186
60MP0005275_abnormal_skin_tensile1.25036682
61MP0000613_abnormal_salivary_gland1.25012283
62MP0002557_abnormal_social/conspecific_i1.24856717
63MP0004215_abnormal_myocardial_fiber1.24471203
64MP0003942_abnormal_urinary_system1.24032910
65MP0008995_early_reproductive_senescence1.22400102
66MP0002184_abnormal_innervation1.22134687
67MP0003385_abnormal_body_wall1.20726633
68MP0003329_amyloid_beta_deposits1.20423707
69MP0001293_anophthalmia1.19967908
70MP0002938_white_spotting1.17233278
71MP0004742_abnormal_vestibular_system1.16367625
72MP0004142_abnormal_muscle_tone1.16015454
73MP0004084_abnormal_cardiac_muscle1.15547297
74MP0002108_abnormal_muscle_morphology1.13597606
75MP0000955_abnormal_spinal_cord1.12989407
76MP0003632_abnormal_nervous_system1.12568637
77MP0000026_abnormal_inner_ear1.12492866
78MP0005167_abnormal_blood-brain_barrier1.10596196
79MP0005257_abnormal_intraocular_pressure1.10166606
80MP0009379_abnormal_foot_pigmentation1.09924958
81MP0002735_abnormal_chemical_nociception1.09542705
82MP0003137_abnormal_impulse_conducting1.08101912
83MP0003634_abnormal_glial_cell1.07774863
84MP0000049_abnormal_middle_ear1.06853487
85MP0003938_abnormal_ear_development1.06412026
86MP0006276_abnormal_autonomic_nervous1.04237707
87MP0009053_abnormal_anal_canal1.03945093
88MP0001984_abnormal_olfaction1.03632874
89MP0005646_abnormal_pituitary_gland1.03529811
90MP0004085_abnormal_heartbeat1.03524586
91MP0002882_abnormal_neuron_morphology1.03509734
92MP0000534_abnormal_ureter_morphology1.03416283
93MP0005623_abnormal_meninges_morphology1.03032559
94MP0001502_abnormal_circadian_rhythm1.02155273
95MP0002089_abnormal_postnatal_growth/wei1.01664020
96MP0008569_lethality_at_weaning1.00109350
97MP0000428_abnormal_craniofacial_morphol0.99037104
98MP0002733_abnormal_thermal_nociception0.97499716
99MP0002638_abnormal_pupillary_reflex0.97456268
100MP0002234_abnormal_pharynx_morphology0.97003927
101MP0002152_abnormal_brain_morphology0.96493995
102MP0005551_abnormal_eye_electrophysiolog0.95647910
103MP0005508_abnormal_skeleton_morphology0.95124138
104MP0005620_abnormal_muscle_contractility0.94493826
105MP0002972_abnormal_cardiac_muscle0.93746890
106MP0001663_abnormal_digestive_system0.93486055
107MP0002295_abnormal_pulmonary_circulatio0.93052535
108MP0001970_abnormal_pain_threshold0.90413247
109MP0010678_abnormal_skin_adnexa0.89060332
110MP0005195_abnormal_posterior_eye0.88890229
111MP0005187_abnormal_penis_morphology0.88136403
112MP0001879_abnormal_lymphatic_vessel0.86963818
113MP0005248_abnormal_Harderian_gland0.86709487
114MP0004036_abnormal_muscle_relaxation0.86630259
115MP0005381_digestive/alimentary_phenotyp0.85930446
116MP0002116_abnormal_craniofacial_bone0.85726571
117MP0002249_abnormal_larynx_morphology0.84986754
118MP0004145_abnormal_muscle_electrophysio0.83991793
119MP0006138_congestive_heart_failure0.82865036
120MP0002066_abnormal_motor_capabilities/c0.82515804
121MP0002133_abnormal_respiratory_system0.82327566
122MP0005388_respiratory_system_phenotype0.82327566
123MP0002751_abnormal_autonomic_nervous0.82291108
124MP0004233_abnormal_muscle_weight0.81660228
125MP0004924_abnormal_behavior0.80920662
126MP0005386_behavior/neurological_phenoty0.80920662
127MP0004133_heterotaxia0.80831060
128MP0005377_hearing/vestibular/ear_phenot0.80550113
129MP0003878_abnormal_ear_physiology0.80550113
130MP0008961_abnormal_basal_metabolism0.80476553
131MP0005595_abnormal_vascular_smooth0.80471124
132MP0000432_abnormal_head_morphology0.80295939
133MP0002697_abnormal_eye_size0.80148525
134MP0001963_abnormal_hearing_physiology0.76712478
135MP0002111_abnormal_tail_morphology0.76225577
136MP0002233_abnormal_nose_morphology0.74153212
137MP0003861_abnormal_nervous_system0.71989189
138MP0000762_abnormal_tongue_morphology0.71680719
139MP0002752_abnormal_somatic_nervous0.70247651
140MP0003879_abnormal_hair_cell0.66582300
141MP0000163_abnormal_cartilage_morphology0.66354406
142MP0001324_abnormal_eye_pigmentation0.64096767
143MP0005391_vision/eye_phenotype0.62703151
144MP0001944_abnormal_pancreas_morphology0.61730135
145MP0002909_abnormal_adrenal_gland0.60855141
146MP0003755_abnormal_palate_morphology0.60114559
147MP0002092_abnormal_eye_morphology0.59875342
148MP0005666_abnormal_adipose_tissue0.59611524
149MP0001346_abnormal_lacrimal_gland0.59095597
150MP0005253_abnormal_eye_physiology0.56529420
151MP0002081_perinatal_lethality0.55892639
152MP0003119_abnormal_digestive_system0.55862340

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic pelvis (HP:0008839)4.87500621
2Fibular aplasia (HP:0002990)4.85009577
3Septo-optic dysplasia (HP:0100842)4.31232589
4Esophageal atresia (HP:0002032)3.99170350
5Aplasia involving bones of the upper limbs (HP:0009823)3.82100848
6Aplasia of the phalanges of the hand (HP:0009802)3.82100848
7Aplasia involving bones of the extremities (HP:0009825)3.82100848
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.73946368
9Absent/shortened dynein arms (HP:0200106)3.73946368
10Ulnar deviation of finger (HP:0009465)3.66228625
11Gastrointestinal atresia (HP:0002589)3.48248257
12Abnormality of the pubic bones (HP:0003172)3.47907020
13Anophthalmia (HP:0000528)3.44501990
14Aplasia/hypoplasia of the uterus (HP:0008684)3.38325132
15Hemivertebrae (HP:0002937)3.34865122
16Focal motor seizures (HP:0011153)3.33684778
17Broad metatarsal (HP:0001783)3.30134839
18Synostosis of carpal bones (HP:0005048)3.24641867
19Rib fusion (HP:0000902)3.24593749
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.20989938
21Midline defect of the nose (HP:0004122)3.20136852
22Carpal synostosis (HP:0009702)3.18022068
23Abnormal ciliary motility (HP:0012262)3.13773977
24Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.05576719
25Symphalangism affecting the phalanges of the hand (HP:0009773)3.00932951
26Bilateral microphthalmos (HP:0007633)2.98069464
27True hermaphroditism (HP:0010459)2.97014871
28Arterial tortuosity (HP:0005116)2.96131273
29Oligodactyly (hands) (HP:0001180)2.90745227
30Aplasia/Hypoplasia of the fibula (HP:0006492)2.90681571
31Abnormality of the diencephalon (HP:0010662)2.88710366
32Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.84781352
33Large for gestational age (HP:0001520)2.83603782
34Abnormality of incisor morphology (HP:0011063)2.80629821
35Vascular tortuosity (HP:0004948)2.78212100
36Narrow nasal bridge (HP:0000446)2.78073760
37Hemiplegia (HP:0002301)2.77877960
38Barrel-shaped chest (HP:0001552)2.77140286
39Focal seizures (HP:0007359)2.74462382
40Premature rupture of membranes (HP:0001788)2.73036959
41Synostosis involving bones of the hand (HP:0004278)2.71010077
42Hemiparesis (HP:0001269)2.70522235
43Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.69553069
44Myokymia (HP:0002411)2.69544392
45Aortic dissection (HP:0002647)2.67861573
46Synostosis involving the elbow (HP:0003938)2.66415954
47Humeroradial synostosis (HP:0003041)2.66415954
48Abnormal finger flexion creases (HP:0006143)2.66317881
49Supernumerary ribs (HP:0005815)2.63957542
50Aplasia cutis congenita (HP:0001057)2.60612365
51Aortic aneurysm (HP:0004942)2.59858561
52Abnormal respiratory motile cilium physiology (HP:0012261)2.55245914
53Hypoplastic iliac wings (HP:0002866)2.54062297
54Diplopia (HP:0000651)2.52511741
55Abnormality of binocular vision (HP:0011514)2.52511741
56Abnormality of the upper arm (HP:0001454)2.52108713
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.51002706
58Partial duplication of thumb phalanx (HP:0009944)2.50907261
59Pancreatic fibrosis (HP:0100732)2.49812695
60Sclerocornea (HP:0000647)2.49674979
61Pancreatic cysts (HP:0001737)2.49543868
62Cystic liver disease (HP:0006706)2.47110289
63Abnormal respiratory epithelium morphology (HP:0012253)2.46969341
64Abnormal respiratory motile cilium morphology (HP:0005938)2.46969341
65Vertebral clefting (HP:0008428)2.45947664
66Abnormality of the humerus (HP:0003063)2.45495627
67Progressive cerebellar ataxia (HP:0002073)2.45378569
68Bilateral sensorineural hearing impairment (HP:0008619)2.45345218
69Morphological abnormality of the middle ear (HP:0008609)2.43336862
70Radial bowing (HP:0002986)2.41258697
71Supernumerary bones of the axial skeleton (HP:0009144)2.38904746
72Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.37736573
73Vertebral hypoplasia (HP:0008417)2.37736573
74Neoplasm of the heart (HP:0100544)2.36992976
75Abnormality of the parietal bone (HP:0002696)2.33446384
76Short foot (HP:0001773)2.30590645
77Partial duplication of the phalanx of hand (HP:0009999)2.29512610
78Gait imbalance (HP:0002141)2.27490031
79Missing ribs (HP:0000921)2.24648148
80Shallow orbits (HP:0000586)2.23157826
81Coronal craniosynostosis (HP:0004440)2.23102399
82Abnormality of the incisor (HP:0000676)2.20769393
83Impulsivity (HP:0100710)2.20262373
84Bronchomalacia (HP:0002780)2.18775512
85Maternal diabetes (HP:0009800)2.17092556
86Congenital primary aphakia (HP:0007707)2.16919725
87Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.16612940
88Medial flaring of the eyebrow (HP:0010747)2.15455691
89Abnormal number of incisors (HP:0011064)2.14527950
90Genetic anticipation (HP:0003743)2.13940836
91Postaxial hand polydactyly (HP:0001162)2.13777841
92Abnormality of the distal phalanx of the thumb (HP:0009617)2.10898053
93Molar tooth sign on MRI (HP:0002419)2.10598847
94Abnormality of midbrain morphology (HP:0002418)2.10598847
95Megalencephaly (HP:0001355)2.10426484
96Absent septum pellucidum (HP:0001331)2.09926321
97Spondylolisthesis (HP:0003302)2.09565388
98Aqueductal stenosis (HP:0002410)2.09014606
99Hyperventilation (HP:0002883)2.08125336
100Specific learning disability (HP:0001328)2.07350302
101Epileptic encephalopathy (HP:0200134)2.07324449
102Aplasia/Hypoplasia of the ulna (HP:0006495)2.06676071
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06439450
104Short 4th metacarpal (HP:0010044)2.06033875
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06033875
106Abnormality of the fibula (HP:0002991)2.04284743
107Abnormality of the right ventricle (HP:0001707)2.02581304
108Optic nerve hypoplasia (HP:0000609)2.02400403
109Tarsal synostosis (HP:0008368)2.01005447
110Broad ribs (HP:0000885)2.00741281
111Large earlobe (HP:0009748)1.99427956
112Nephrogenic diabetes insipidus (HP:0009806)1.97698439
113Synostosis involving bones of the lower limbs (HP:0009138)1.97615312
114Synostosis involving bones of the feet (HP:0009140)1.97615312
115Abnormality of the calf musculature (HP:0001430)1.96270032
116Congenital stationary night blindness (HP:0007642)1.95562519
117Oligodactyly (HP:0012165)1.94922510
118Preaxial foot polydactyly (HP:0001841)1.94354528
119Skull defect (HP:0001362)1.94059467
120Widely patent fontanelles and sutures (HP:0004492)1.93200539
121Renal dysplasia (HP:0000110)1.93133306
122Genital tract atresia (HP:0001827)1.92841362
123Pulmonary artery stenosis (HP:0004415)1.90773667
124Adactyly (HP:0009776)1.90662975
125Thickened helices (HP:0000391)1.90344232
126Action tremor (HP:0002345)1.89814579
127Abnormality of the 4th metacarpal (HP:0010012)1.88871319
128Abnormality of the lacrimal duct (HP:0011481)1.87170792
129Tubulointerstitial fibrosis (HP:0005576)1.87150334
130Bifid tongue (HP:0010297)1.87086704
131Dysdiadochokinesis (HP:0002075)1.86711995
132Alacrima (HP:0000522)1.86423716
133Vaginal atresia (HP:0000148)1.85514254
134Febrile seizures (HP:0002373)1.85455640
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84357708
136Scrotal hypoplasia (HP:0000046)1.83987695
137Spastic diplegia (HP:0001264)1.83779705
138Abnormality of the middle phalanges of the toes (HP:0010183)1.83184750
139Meningocele (HP:0002435)1.82488121
140Broad-based gait (HP:0002136)1.82247156
141Hypoventilation (HP:0002791)1.81063221
142Prolonged QT interval (HP:0001657)1.79918831
143Short hallux (HP:0010109)1.79841583
144Patellar aplasia (HP:0006443)1.79610000
145Central scotoma (HP:0000603)1.79071775
146Mixed hearing impairment (HP:0000410)1.78965573
147Bowed forearm bones (HP:0003956)1.78015946
148Bowing of the arm (HP:0006488)1.78015946
149Atrial fibrillation (HP:0005110)1.77785775
150Calf muscle hypertrophy (HP:0008981)1.77234948
151Supranuclear gaze palsy (HP:0000605)1.77060304
152Abnormality of the nasolacrimal system (HP:0000614)1.76953358
153Soft skin (HP:0000977)1.76217724
154Narrow palate (HP:0000189)1.76142314
155Labial hypoplasia (HP:0000066)1.75755170
156Trigonocephaly (HP:0000243)1.74534370
157Atonic seizures (HP:0010819)1.74374252
158Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.73626495
159Decreased circulating renin level (HP:0003351)1.73530497
160Generalized tonic-clonic seizures (HP:0002069)1.73390246
161Drooling (HP:0002307)1.72895224
162Excessive salivation (HP:0003781)1.72895224
163Primary atrial arrhythmia (HP:0001692)1.72862022
164Sudden death (HP:0001699)1.71840183
165Potter facies (HP:0002009)1.71448613
166Facial shape deformation (HP:0011334)1.71448613
167Anosmia (HP:0000458)1.70597536
168Blue irides (HP:0000635)1.70424091
169Hypoplastic left heart (HP:0004383)1.70039086
170Split foot (HP:0001839)1.69216353
171Chorioretinal atrophy (HP:0000533)1.69150167
172Visual hallucinations (HP:0002367)1.69143618
173Increased corneal curvature (HP:0100692)1.68001556
174Keratoconus (HP:0000563)1.68001556
175Hypoplastic nipples (HP:0002557)1.67020002
176Wide anterior fontanel (HP:0000260)1.66172070
177Overgrowth (HP:0001548)1.62975222
178Ectopic anus (HP:0004397)1.62583905
179Double outlet right ventricle (HP:0001719)1.62316978
180Congenital malformation of the right heart (HP:0011723)1.62316978
181Short middle phalanx of the 5th finger (HP:0004220)1.62033871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.42255374
2NTRK33.79930015
3EPHA33.60744038
4KSR13.54542517
5TNIK3.12790038
6CASK3.09186417
7EPHB22.93616953
8EPHA42.90167575
9PINK12.71173046
10TSSK62.48095355
11NTRK22.39784002
12BMPR1B2.36715636
13WEE12.20149045
14PLK22.19435992
15MARK12.11901168
16MINK12.07484787
17MYLK2.01669507
18MAP3K41.91587938
19MAP3K91.89565399
20SIK31.88667754
21OBSCN1.87007627
22MAPK131.77735792
23PDGFRA1.76850991
24MAP2K71.65914459
25EPHB11.61729095
26TGFBR11.58205950
27IKBKE1.51652032
28BCR1.50014255
29RIPK41.44641801
30PHKG11.42718157
31PHKG21.42718157
32MAP3K121.42122832
33NEK61.41190181
34IRAK11.40701692
35BCKDK1.38611405
36DMPK1.30713045
37NTRK11.27963002
38CDC42BPA1.23771135
39LMTK21.22845626
40PAK61.22173836
41LATS11.19587296
42TYRO31.18591123
43DDR21.18502667
44ADRBK21.18145298
45CDK31.17431354
46STK38L1.17161643
47ERBB31.16520241
48PIK3CA1.15804670
49PAK31.15528184
50KSR21.15486287
51ROCK11.15024149
52FER1.12964840
53ROCK21.09253776
54VRK11.04705811
55STK241.03633720
56CHUK1.03069830
57SGK21.01997139
58MAP3K70.99982437
59CAMK1G0.99635651
60CAMK2A0.99602946
61CDK80.99310175
62PRKCG0.97270063
63CDK50.96945040
64LATS20.95617204
65SGK4940.95388155
66SGK2230.95388155
67FGFR20.95351631
68PTK2B0.94096805
69STK380.92457347
70MAP2K40.92331607
71UHMK10.87753899
72PTK60.87413303
73TGFBR20.87287577
74PNCK0.87234290
75DYRK20.84832197
76GRK50.83548568
77GRK70.83385909
78ERBB20.82988385
79NME10.79238044
80STK40.78411361
81PRKCE0.77257474
82MAP3K130.75592827
83PRKD30.75552723
84ACVR1B0.73655578
85FGFR10.72294839
86PRPF4B0.69841730
87PAK20.69617554
88CDK180.69417480
89CAMK10.68442394
90MUSK0.67757550
91BMPR20.67699248
92SGK10.66777066
93MAP3K100.65566520
94NEK90.63944634
95SIK10.63573103
96PIM10.62475857
97FES0.61989078
98DYRK1A0.61411196
99PDGFRB0.61064754
100WNK30.59471973
101SGK30.59419024
102CAMK2B0.59053223
103CDK150.57820476
104MAP2K20.57695862
105YES10.57595841
106CDK140.56776261
107DYRK1B0.56137214
108TIE10.55528691
109WNK40.54636839
110BMX0.53692471
111FRK0.52741972
112MAPK120.49635889
113SRC0.49616188
114GRK10.49253894
115FYN0.49079184
116CAMK2D0.49055336
117CAMK1D0.49030492
118PRKCZ0.48285267
119SIK20.47587979
120IRAK20.47260070
121PRKG10.47158575
122MOS0.46992980
123INSRR0.45837038
124PRKACA0.45688300
125CDK11A0.45298394
126PKN10.44954625
127PRKAA20.44781213
128ARAF0.44587807
129MAP2K10.44280429
130ADRBK10.44209946
131CAMKK10.42547498
132CSNK1G20.42500377
133MAP3K20.41623062
134DAPK20.40229554
135CDK90.40004039
136CAMK2G0.39816041
137IGF1R0.39608016
138GSK3A0.39408708
139WNK10.38100282
140AKT30.37180118
141AKT10.33604433
142IKBKB0.32675116
143NLK0.31963108
144RPS6KA30.31436479
145TEC0.30240944
146FGFR30.27972448
147RPS6KA40.27632835
148IRAK40.26333297
149RIPK10.25877152
150PRKCH0.24045513

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.35569154
2Nicotine addiction_Homo sapiens_hsa050333.22993400
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.21903082
4Circadian entrainment_Homo sapiens_hsa047132.25287040
5Glutamatergic synapse_Homo sapiens_hsa047242.18873988
6GABAergic synapse_Homo sapiens_hsa047272.15046213
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13916207
8Propanoate metabolism_Homo sapiens_hsa006402.13579476
9Basal cell carcinoma_Homo sapiens_hsa052171.98695731
10Long-term potentiation_Homo sapiens_hsa047201.97374171
11Morphine addiction_Homo sapiens_hsa050321.86831169
12Salivary secretion_Homo sapiens_hsa049701.82760190
13Hedgehog signaling pathway_Homo sapiens_hsa043401.81937234
14Axon guidance_Homo sapiens_hsa043601.81643941
15Renin secretion_Homo sapiens_hsa049241.81011430
16Dilated cardiomyopathy_Homo sapiens_hsa054141.79945170
17Amphetamine addiction_Homo sapiens_hsa050311.75574527
18Taste transduction_Homo sapiens_hsa047421.71082316
19Olfactory transduction_Homo sapiens_hsa047401.70106290
20Gastric acid secretion_Homo sapiens_hsa049711.66353788
21Cardiac muscle contraction_Homo sapiens_hsa042601.66271427
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65010905
23Calcium signaling pathway_Homo sapiens_hsa040201.60117391
24Melanogenesis_Homo sapiens_hsa049161.59356312
25Synaptic vesicle cycle_Homo sapiens_hsa047211.58473619
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58292018
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56995678
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56737159
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56215074
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55564287
31Insulin secretion_Homo sapiens_hsa049111.54459581
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53297230
33Dopaminergic synapse_Homo sapiens_hsa047281.49347577
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48441544
35Long-term depression_Homo sapiens_hsa047301.44065780
36Serotonergic synapse_Homo sapiens_hsa047261.39509613
37cAMP signaling pathway_Homo sapiens_hsa040241.36551662
38Oxytocin signaling pathway_Homo sapiens_hsa049211.31238615
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30442471
40Gap junction_Homo sapiens_hsa045401.28410439
41Cholinergic synapse_Homo sapiens_hsa047251.27448096
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22780946
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20094521
44Nitrogen metabolism_Homo sapiens_hsa009101.18713415
45Wnt signaling pathway_Homo sapiens_hsa043101.17199802
46Thyroid hormone synthesis_Homo sapiens_hsa049181.16674141
47Dorso-ventral axis formation_Homo sapiens_hsa043201.16562306
48Ether lipid metabolism_Homo sapiens_hsa005651.14640135
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14583990
50ECM-receptor interaction_Homo sapiens_hsa045121.13155531
51GnRH signaling pathway_Homo sapiens_hsa049121.12764480
52Linoleic acid metabolism_Homo sapiens_hsa005911.12705312
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.12588470
54Cocaine addiction_Homo sapiens_hsa050301.12272818
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11229633
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10581754
57Parkinsons disease_Homo sapiens_hsa050121.08734862
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04145628
59Hippo signaling pathway_Homo sapiens_hsa043901.04111250
60Histidine metabolism_Homo sapiens_hsa003401.01262787
61Estrogen signaling pathway_Homo sapiens_hsa049150.94420319
62Phototransduction_Homo sapiens_hsa047440.94337496
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93492536
64Protein export_Homo sapiens_hsa030600.87124899
65Vitamin digestion and absorption_Homo sapiens_hsa049770.85570335
66Pancreatic secretion_Homo sapiens_hsa049720.84595559
67Glioma_Homo sapiens_hsa052140.84543782
68Focal adhesion_Homo sapiens_hsa045100.81074967
69Collecting duct acid secretion_Homo sapiens_hsa049660.80716913
70TGF-beta signaling pathway_Homo sapiens_hsa043500.78428110
71Adherens junction_Homo sapiens_hsa045200.76820178
72Proteoglycans in cancer_Homo sapiens_hsa052050.75550680
73beta-Alanine metabolism_Homo sapiens_hsa004100.75512107
74Notch signaling pathway_Homo sapiens_hsa043300.75442793
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74518974
76Fatty acid biosynthesis_Homo sapiens_hsa000610.73280306
77Type II diabetes mellitus_Homo sapiens_hsa049300.71608948
78Tryptophan metabolism_Homo sapiens_hsa003800.71093016
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70911704
80Ribosome_Homo sapiens_hsa030100.69812921
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.68299617
82Rap1 signaling pathway_Homo sapiens_hsa040150.67728791
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67604328
84Prion diseases_Homo sapiens_hsa050200.67188204
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66583021
86Bile secretion_Homo sapiens_hsa049760.66532184
87ErbB signaling pathway_Homo sapiens_hsa040120.66292719
88Butanoate metabolism_Homo sapiens_hsa006500.65022342
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63856068
90PPAR signaling pathway_Homo sapiens_hsa033200.63830005
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61743131
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61471222
93Protein digestion and absorption_Homo sapiens_hsa049740.61307209
94Choline metabolism in cancer_Homo sapiens_hsa052310.60736417
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59582710
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59329030
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59314802
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58832187
99Alzheimers disease_Homo sapiens_hsa050100.58192205
100Ovarian steroidogenesis_Homo sapiens_hsa049130.57518326
101Ras signaling pathway_Homo sapiens_hsa040140.57120951
102MAPK signaling pathway_Homo sapiens_hsa040100.56027899
103Vibrio cholerae infection_Homo sapiens_hsa051100.54568837
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54013026
105Tight junction_Homo sapiens_hsa045300.53643883
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.52539513
107Retinol metabolism_Homo sapiens_hsa008300.52053721
108AMPK signaling pathway_Homo sapiens_hsa041520.51493887
109Oxidative phosphorylation_Homo sapiens_hsa001900.51005173
110Oocyte meiosis_Homo sapiens_hsa041140.50983511
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50893576
112Steroid biosynthesis_Homo sapiens_hsa001000.50825837
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50313299
114Glycerolipid metabolism_Homo sapiens_hsa005610.48992873
115Complement and coagulation cascades_Homo sapiens_hsa046100.46471419
116Fanconi anemia pathway_Homo sapiens_hsa034600.45891828
117Mineral absorption_Homo sapiens_hsa049780.45083726
118Circadian rhythm_Homo sapiens_hsa047100.44183335
119ABC transporters_Homo sapiens_hsa020100.43868578
120Melanoma_Homo sapiens_hsa052180.43668747
121Pathways in cancer_Homo sapiens_hsa052000.43534136
122Pyruvate metabolism_Homo sapiens_hsa006200.42177834
123Glucagon signaling pathway_Homo sapiens_hsa049220.41962532
124Amoebiasis_Homo sapiens_hsa051460.41403938
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.41205142
126Arachidonic acid metabolism_Homo sapiens_hsa005900.39601955
127Renal cell carcinoma_Homo sapiens_hsa052110.38842179
128Fat digestion and absorption_Homo sapiens_hsa049750.38784406
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38039256
130Alcoholism_Homo sapiens_hsa050340.37861527
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37810059
132Viral myocarditis_Homo sapiens_hsa054160.37258616
133Colorectal cancer_Homo sapiens_hsa052100.37254882
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33777721
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33448664
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33335376

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