SPON2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)7.66179752
2biotin metabolic process (GO:0006768)6.68403616
3positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.90779779
4peptidyl-tyrosine autophosphorylation (GO:0038083)5.36913291
5artery development (GO:0060840)5.27568026
6protein heterotrimerization (GO:0070208)5.22872273
7prostate gland epithelium morphogenesis (GO:0060740)5.18297967
8long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.16305305
9carnitine shuttle (GO:0006853)5.10707060
10regulation of receptor binding (GO:1900120)5.06432847
11regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.85187601
12peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.68291523
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.62217299
14positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.58685601
15regulation of protein activation cascade (GO:2000257)4.57256105
16fatty-acyl-CoA biosynthetic process (GO:0046949)4.55628489
17collagen fibril organization (GO:0030199)4.52122671
18regulation of complement activation (GO:0030449)4.50994714
19peptidyl-glutamic acid carboxylation (GO:0017187)4.50563336
20protein carboxylation (GO:0018214)4.50563336
21iron ion import (GO:0097286)4.46864335
22positive regulation of histone deacetylation (GO:0031065)4.46207723
23epithelial cell maturation (GO:0002070)4.28382245
24keratan sulfate catabolic process (GO:0042340)4.27396164
25COPI coating of Golgi vesicle (GO:0048205)4.25827063
26Golgi transport vesicle coating (GO:0048200)4.25827063
27acetyl-CoA metabolic process (GO:0006084)4.21100142
28negative regulation of fibrinolysis (GO:0051918)4.17304846
29complement activation, alternative pathway (GO:0006957)4.13184487
30negative regulation of protein activation cascade (GO:2000258)4.12301456
31response to testosterone (GO:0033574)4.11625867
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.08868490
33positive regulation of cellular amine metabolic process (GO:0033240)4.07263425
34epithelial cell differentiation involved in prostate gland development (GO:0060742)4.02296034
35sulfur amino acid catabolic process (GO:0000098)4.01639148
36endothelial cell chemotaxis (GO:0035767)4.00848423
37regulation of fibrinolysis (GO:0051917)3.99097322
38L-phenylalanine catabolic process (GO:0006559)3.98936209
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98936209
40protein retention in ER lumen (GO:0006621)3.98775403
41negative regulation of complement activation (GO:0045916)3.96993220
42regulation of protein polyubiquitination (GO:1902914)3.93525324
43L-phenylalanine metabolic process (GO:0006558)3.92546452
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.92546452
45positive regulation of steroid hormone secretion (GO:2000833)3.92006204
46fatty acid transmembrane transport (GO:1902001)3.90925443
47regulation of plasminogen activation (GO:0010755)3.88969437
48dermatan sulfate biosynthetic process (GO:0030208)3.78580024
49skin morphogenesis (GO:0043589)3.77759399
50fibrinolysis (GO:0042730)3.77296595
51carnitine transmembrane transport (GO:1902603)3.73700352
52vascular endothelial growth factor signaling pathway (GO:0038084)3.71255113
53thioester biosynthetic process (GO:0035384)3.71212459
54acyl-CoA biosynthetic process (GO:0071616)3.71212459
55pharyngeal system development (GO:0060037)3.69800426
56establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.67655183
57extracellular fibril organization (GO:0043206)3.67173474
58alpha-linolenic acid metabolic process (GO:0036109)3.67083967
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.64913214
60lung epithelial cell differentiation (GO:0060487)3.59769390
61mitotic cell cycle arrest (GO:0071850)3.59395776
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.55528879
63regulation of ARF protein signal transduction (GO:0032012)3.52519033
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.52162231
65lung cell differentiation (GO:0060479)3.46276395
66negative regulation of cell size (GO:0045792)3.46263948
67dermatan sulfate metabolic process (GO:0030205)3.44962629
68very-low-density lipoprotein particle assembly (GO:0034379)3.44485365
69regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.44274150
70bile acid biosynthetic process (GO:0006699)3.43545128
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.41924067
72amino-acid betaine transport (GO:0015838)3.40416915
73carnitine transport (GO:0015879)3.40416915
74homocysteine metabolic process (GO:0050667)3.39208438
75regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36601906
76regulation of endothelial cell chemotaxis (GO:2001026)3.31169709
77coenzyme A biosynthetic process (GO:0015937)3.30804107
78ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.27161193
79nucleoside bisphosphate biosynthetic process (GO:0033866)3.27161193
80purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.27161193
81regulation of fatty acid beta-oxidation (GO:0031998)3.26353954
82COPII vesicle coating (GO:0048208)3.25427923
83protein maturation by protein folding (GO:0022417)3.25141454
84insulin-like growth factor receptor signaling pathway (GO:0048009)3.24995261
85mitochondrion degradation (GO:0000422)3.24740648
86positive regulation of protein deacetylation (GO:0090312)3.24045277
87fibril organization (GO:0097435)3.23741897
88basement membrane organization (GO:0071711)3.23567507
89glyoxylate metabolic process (GO:0046487)3.21105960
90aromatic amino acid family catabolic process (GO:0009074)3.20796782
91Golgi to endosome transport (GO:0006895)3.20447650
92sulfur compound catabolic process (GO:0044273)3.19883167
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18415689
94bile acid and bile salt transport (GO:0015721)3.18353207
95import into cell (GO:0098657)3.18268420
96glucocorticoid receptor signaling pathway (GO:0042921)3.17569315
97type B pancreatic cell proliferation (GO:0044342)3.17407624
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.14229559
99high-density lipoprotein particle remodeling (GO:0034375)3.13170638
1004-hydroxyproline metabolic process (GO:0019471)3.13034334
101UDP-N-acetylglucosamine metabolic process (GO:0006047)3.11190951
102cellular glucuronidation (GO:0052695)3.08636410
103plasma lipoprotein particle clearance (GO:0034381)3.08494338
104cell migration involved in heart development (GO:0060973)3.08107735
105intestinal epithelial cell development (GO:0060576)3.05857053
106positive regulation of fatty acid oxidation (GO:0046321)3.05770128
107collagen metabolic process (GO:0032963)3.04707330
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.03892009
109acylglycerol homeostasis (GO:0055090)2.99928072
110triglyceride homeostasis (GO:0070328)2.99928072
111semaphorin-plexin signaling pathway (GO:0071526)2.99124780
112regulation of glucose import in response to insulin stimulus (GO:2001273)2.96533444
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.95653047
114endodermal cell differentiation (GO:0035987)2.95591101
115regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.94331775
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93876985
117negative regulation of fatty acid transport (GO:2000192)2.93854369
118* opsonization (GO:0008228)2.93296969
119cysteine metabolic process (GO:0006534)2.93248729
120blood vessel maturation (GO:0001955)2.93144299
121positive regulation of osteoblast proliferation (GO:0033690)2.92965670
122low-density lipoprotein particle clearance (GO:0034383)2.92343637
123lung lobe morphogenesis (GO:0060463)2.91630970
124multicellular organismal macromolecule metabolic process (GO:0044259)2.91504577
125regulation of histone deacetylation (GO:0031063)2.89450126
126protein autoprocessing (GO:0016540)2.89442678
127cell-cell junction maintenance (GO:0045217)2.89271107
128regulation of triglyceride catabolic process (GO:0010896)2.88193164
129collagen catabolic process (GO:0030574)2.87338561
130lysine catabolic process (GO:0006554)2.85847281
131lysine metabolic process (GO:0006553)2.85847281
132bile acid metabolic process (GO:0008206)2.84158071
133multicellular organismal metabolic process (GO:0044236)2.83988572
134quaternary ammonium group transport (GO:0015697)2.83326895
135reverse cholesterol transport (GO:0043691)2.82939950
136negative regulation of blood coagulation (GO:0030195)2.81417789
137negative regulation of hemostasis (GO:1900047)2.81417789
138glandular epithelial cell differentiation (GO:0002067)2.80954421
139bone trabecula formation (GO:0060346)2.80450386
140regulation of transcription from RNA polymerase III promoter (GO:0006359)2.79147147
141beta-amyloid metabolic process (GO:0050435)2.77942723
142fatty-acyl-CoA metabolic process (GO:0035337)2.77170837
143complement activation, classical pathway (GO:0006958)2.75540622
144positive regulation of DNA biosynthetic process (GO:2000573)2.74289856
145extracellular matrix disassembly (GO:0022617)2.74243304
146multicellular organismal catabolic process (GO:0044243)2.74142579
147positive regulation of glycogen biosynthetic process (GO:0045725)2.73675279
148regulation of viral entry into host cell (GO:0046596)2.72719397
149positive regulation of fatty acid metabolic process (GO:0045923)2.72711090
150response to nitrosative stress (GO:0051409)2.71530784
151complement activation (GO:0006956)2.69903138
152endothelial cell morphogenesis (GO:0001886)2.69211834
153kynurenine metabolic process (GO:0070189)2.69139941
154regulation of cholesterol homeostasis (GO:2000188)2.68938335
155positive regulation of smoothened signaling pathway (GO:0045880)2.68887552
156protein-lipid complex remodeling (GO:0034368)2.68844974
157macromolecular complex remodeling (GO:0034367)2.68844974
158plasma lipoprotein particle remodeling (GO:0034369)2.68844974
159positive regulation of respiratory burst (GO:0060267)2.68827913
160amino-acid betaine metabolic process (GO:0006577)2.66158185
161diaphragm development (GO:0060539)2.65707379
162endoplasmic reticulum organization (GO:0007029)2.65590087
163nucleotide-sugar biosynthetic process (GO:0009226)2.64640696
164lipoprotein metabolic process (GO:0042157)2.64320984
165establishment of apical/basal cell polarity (GO:0035089)2.64320140
166endothelial cell proliferation (GO:0001935)2.64100744
167negative regulation of coagulation (GO:0050819)2.63142913
168cellular response to prostaglandin stimulus (GO:0071379)2.62996752
169tryptophan metabolic process (GO:0006568)2.62857593
170negative regulation of lipase activity (GO:0060192)2.62724689
171xenobiotic catabolic process (GO:0042178)2.62228987
172positive regulation of fatty acid biosynthetic process (GO:0045723)2.62178961
173positive regulation of lipid catabolic process (GO:0050996)2.61941309
174corticosteroid receptor signaling pathway (GO:0031958)2.61737566
175uronic acid metabolic process (GO:0006063)2.61649686
176glucuronate metabolic process (GO:0019585)2.61649686
177fatty acid beta-oxidation (GO:0006635)2.61597997
178positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.59442860
179negative regulation of wound healing (GO:0061045)2.59045221
180tryptophan catabolic process (GO:0006569)2.58914318
181indole-containing compound catabolic process (GO:0042436)2.58914318
182indolalkylamine catabolic process (GO:0046218)2.58914318
183negative regulation of DNA repair (GO:0045738)2.58605410
184regulation of cholesterol biosynthetic process (GO:0045540)2.58473061
185adherens junction assembly (GO:0034333)2.56081364
186cell-substrate adherens junction assembly (GO:0007045)2.55552711
187focal adhesion assembly (GO:0048041)2.55552711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.30245635
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.29613671
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.93739184
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67936919
5GATA1_22025678_ChIP-Seq_K562_Human4.33351547
6RARG_19884340_ChIP-ChIP_MEFs_Mouse4.25477853
7PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22217205
8LXR_22158963_ChIP-Seq_LIVER_Mouse4.06679257
9* CLOCK_20551151_ChIP-Seq_293T_Human3.70529231
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.47660414
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.27711711
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.27104557
13PIAS1_25552417_ChIP-Seq_VCAP_Human3.18254068
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.84119753
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.72853833
16AR_21909140_ChIP-Seq_LNCAP_Human2.70559152
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.62554764
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56091957
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54022449
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.48435942
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.38248486
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36239217
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.33869411
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21253127
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16899414
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11617123
27VDR_21846776_ChIP-Seq_THP-1_Human2.08591831
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04166623
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03641398
30FOXA1_25552417_ChIP-Seq_VCAP_Human2.01407403
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00812436
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94768225
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90184073
34* CHD1_26751641_Chip-Seq_LNCaP_Human1.89993733
35TCF7_22412390_ChIP-Seq_EML_Mouse1.87575915
36CJUN_26792858_Chip-Seq_BT549_Human1.86616873
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84838199
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.81001911
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.80101259
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.80090838
41CREB1_26743006_Chip-Seq_LNCaP_Human1.76116548
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74734105
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73852721
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72137483
45KDM2B_26808549_Chip-Seq_DND41_Human1.70138921
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67823086
47KDM2B_26808549_Chip-Seq_K562_Human1.65753845
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64998415
49* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.62209987
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59331601
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53401052
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53401052
53MYC_22102868_ChIP-Seq_BL_Human1.52376967
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52205698
55* SOX2_20726797_ChIP-Seq_SW620_Human1.49241430
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49230607
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49158372
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48552907
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47871821
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47057594
61SMC4_20622854_ChIP-Seq_HELA_Human1.46318901
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45921718
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43760780
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39530631
65BRD4_25478319_ChIP-Seq_HGPS_Human1.38720585
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.36910774
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35477045
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34454026
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.33318070
70* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33300284
71P68_20966046_ChIP-Seq_HELA_Human1.33198513
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30612330
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30612330
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30612330
75VDR_24763502_ChIP-Seq_THP-1_Human1.30525524
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30211461
77TP53_22127205_ChIP-Seq_IMR90_Human1.29949920
78DROSHA_22980978_ChIP-Seq_HELA_Human1.29134373
79* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27501871
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.27042500
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25611080
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22733833
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.20248072
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18947854
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18773384
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17604917
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17475793
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.16409966
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16188902
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16174115
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16063127
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15960351
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.15654212
94CTCF_27219007_Chip-Seq_Bcells_Human1.15426801
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15050065
96AR_21572438_ChIP-Seq_LNCaP_Human1.15028527
97ERG_20517297_ChIP-Seq_VCAP_Human1.12537863
98* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10978351
99* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10978351
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10787011
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.10673807
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10509896
103FOXA2_19822575_ChIP-Seq_HepG2_Human1.09814995
104* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07872688
105* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07872688
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06848119
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06526827
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06468681
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.05556455
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04677916
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03901371
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03440004
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02309203
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.02267751
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.01796367
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01504534
117RACK7_27058665_Chip-Seq_MCF-7_Human1.01443412
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01296557
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.00174020
120TP63_22573176_ChIP-Seq_HFKS_Human1.00083168
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.99995739
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98470965
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98192844
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.97661345
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.97273970
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96515628
127ATF3_27146783_Chip-Seq_COLON_Human0.96359885
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96137963
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.96081892
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95663801
131GATA4_25053715_ChIP-Seq_YYC3_Human0.95600513
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94912081
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94821519
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93476744
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93140745
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93067483
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92120576
138TP53_18474530_ChIP-ChIP_U2OS_Human0.91228693
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88022036
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85553593
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82350466
142ZNF263_19887448_ChIP-Seq_K562_Human0.81885788
143GATA1_19941826_ChIP-Seq_K562_Human0.81356631
144HNF4A_19822575_ChIP-Seq_HepG2_Human0.81230460
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.80815470
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.79927703
147* LXR_22292898_ChIP-Seq_THP-1_Human0.79330308
148UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77645067
149BCAT_22108803_ChIP-Seq_LS180_Human0.76317805
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75788722
151SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75525049
152CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74984458
153* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74152754
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73775181
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73260562
156FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72046887
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72028612
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71851321
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70979825
160ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69923551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.43980602
2MP0005503_abnormal_tendon_morphology5.74513315
3MP0002009_preneoplasia5.74287825
4MP0005275_abnormal_skin_tensile5.33251327
5MP0000537_abnormal_urethra_morphology4.85168671
6MP0002166_altered_tumor_susceptibility4.80003530
7MP0004858_abnormal_nervous_system4.79504887
8MP0004145_abnormal_muscle_electrophysio4.08338820
9MP0002139_abnormal_hepatobiliary_system3.98176080
10MP0002006_tumorigenesis3.47920437
11MP0003315_abnormal_perineum_morphology3.26858132
12MP0005645_abnormal_hypothalamus_physiol3.18661105
13MP0006054_spinal_hemorrhage3.14749743
14MP0005365_abnormal_bile_salt3.11467229
15MP0005310_abnormal_salivary_gland2.91068536
16MP0003705_abnormal_hypodermis_morpholog2.90111449
17MP0005085_abnormal_gallbladder_physiolo2.86474904
18MP0002822_catalepsy2.83997504
19MP0004272_abnormal_basement_membrane2.82311994
20MP0005360_urolithiasis2.64276067
21MP0005451_abnormal_body_composition2.61853110
22MP0003252_abnormal_bile_duct2.56217085
23MP0010368_abnormal_lymphatic_system2.45826392
24MP0003279_aneurysm2.39705548
25MP0003806_abnormal_nucleotide_metabolis2.39606919
26MP0004185_abnormal_adipocyte_glucose2.35268386
27MP0000538_abnormal_urinary_bladder2.27662585
28MP0001958_emphysema2.19552670
29MP0002060_abnormal_skin_morphology2.14753392
30MP0002234_abnormal_pharynx_morphology2.06707895
31MP0008961_abnormal_basal_metabolism2.06430295
32MP0001873_stomach_inflammation1.99663324
33MP0002138_abnormal_hepatobiliary_system1.94906851
34MP0005257_abnormal_intraocular_pressure1.91517248
35MP0005508_abnormal_skeleton_morphology1.89854617
36MP0000013_abnormal_adipose_tissue1.86811607
37MP0002108_abnormal_muscle_morphology1.80422019
38MP0003195_calcinosis1.77078970
39MP0005647_abnormal_sex_gland1.76148068
40MP0010234_abnormal_vibrissa_follicle1.72585507
41MP0003566_abnormal_cell_adhesion1.68352906
42MP0005023_abnormal_wound_healing1.67157924
43MP0008875_abnormal_xenobiotic_pharmacok1.63584234
44MP0002735_abnormal_chemical_nociception1.58129174
45MP0001243_abnormal_dermal_layer1.55329124
46MP0003879_abnormal_hair_cell1.51917867
47MP0010329_abnormal_lipoprotein_level1.51656095
48MP0002295_abnormal_pulmonary_circulatio1.48912279
49MP0005076_abnormal_cell_differentiation1.47888884
50MP0000516_abnormal_urinary_system1.39705588
51MP0005367_renal/urinary_system_phenotyp1.39705588
52MP0004233_abnormal_muscle_weight1.38167054
53MP0001879_abnormal_lymphatic_vessel1.29361463
54MP0001348_abnormal_lacrimal_gland1.28735494
55MP0003724_increased_susceptibility_to1.26159780
56MP0002909_abnormal_adrenal_gland1.23967160
57MP0002876_abnormal_thyroid_physiology1.22016015
58MP0002877_abnormal_melanocyte_morpholog1.21603026
59MP0001542_abnormal_bone_strength1.20330837
60MP0005666_abnormal_adipose_tissue1.19688781
61MP0005332_abnormal_amino_acid1.17763276
62MP0009384_cardiac_valve_regurgitation1.17595328
63MP0004036_abnormal_muscle_relaxation1.14798141
64MP0000003_abnormal_adipose_tissue1.11869408
65MP0000733_abnormal_muscle_development1.10137001
66MP0005390_skeleton_phenotype1.09902040
67MP0009840_abnormal_foam_cell1.08616394
68MP0003656_abnormal_erythrocyte_physiolo1.07657861
69MP0005084_abnormal_gallbladder_morpholo1.06453314
70MP0000751_myopathy1.05367377
71MP0000609_abnormal_liver_physiology1.03410454
72MP0002896_abnormal_bone_mineralization1.02134905
73MP0001666_abnormal_nutrient_absorption0.98695211
74MP0005083_abnormal_biliary_tract0.97698460
75MP0003942_abnormal_urinary_system0.97499067
76MP0000767_abnormal_smooth_muscle0.97378696
77MP0002837_dystrophic_cardiac_calcinosis0.96688630
78MP0005319_abnormal_enzyme/_coenzyme0.92268713
79MP0005330_cardiomyopathy0.90169996
80MP0002933_joint_inflammation0.89393466
81MP0004019_abnormal_vitamin_homeostasis0.88880476
82MP0002118_abnormal_lipid_homeostasis0.88599072
83MP0001919_abnormal_reproductive_system0.87840321
84MP0000163_abnormal_cartilage_morphology0.86654255
85MP0005167_abnormal_blood-brain_barrier0.83387113
86MP0002282_abnormal_trachea_morphology0.81448570
87MP0001533_abnormal_skeleton_physiology0.80670432
88MP0001661_extended_life_span0.79091588
89MP0005220_abnormal_exocrine_pancreas0.78736849
90MP0003448_altered_tumor_morphology0.78537903
91MP0000750_abnormal_muscle_regeneration0.78363461
92MP0005164_abnormal_response_to0.77141090
93MP0002168_other_aberrant_phenotype0.77053665
94MP0000749_muscle_degeneration0.76785948
95MP0003091_abnormal_cell_migration0.76133699
96MP0005670_abnormal_white_adipose0.75070626
97MP0003191_abnormal_cellular_cholesterol0.73317653
98MP0009643_abnormal_urine_homeostasis0.72977931
99MP0001756_abnormal_urination0.72343295
100MP0009250_abnormal_appendicular_skeleto0.71207901
101MP0005375_adipose_tissue_phenotype0.71160233
102MP0010030_abnormal_orbit_morphology0.70802868
103MP0003011_delayed_dark_adaptation0.70627543
104MP0003115_abnormal_respiratory_system0.68596551
105MP0005595_abnormal_vascular_smooth0.68229312
106MP0000747_muscle_weakness0.67569535
107MP0002128_abnormal_blood_circulation0.67340342
108MP0001765_abnormal_ion_homeostasis0.66994439
109MP0002089_abnormal_postnatal_growth/wei0.65896161
110MP0002115_abnormal_skeleton_extremities0.65730056
111MP0005623_abnormal_meninges_morphology0.65327546
112MP0000627_abnormal_mammary_gland0.65262063
113MP0000534_abnormal_ureter_morphology0.64276093
114MP0000598_abnormal_liver_morphology0.62809998
115MP0005058_abnormal_lysosome_morphology0.62673013
116MP0003186_abnormal_redox_activity0.62301071
117MP0005636_abnormal_mineral_homeostasis0.61191876
118MP0005165_increased_susceptibility_to0.59725070
119MP0000920_abnormal_myelination0.58882233
120MP0009764_decreased_sensitivity_to0.58368771
121MP0003283_abnormal_digestive_organ0.58156978
122MP0000462_abnormal_digestive_system0.58153173
123MP0008260_abnormal_autophagy0.58105542
124MP0000249_abnormal_blood_vessel0.57584956
125MP0000678_abnormal_parathyroid_gland0.57567182
126MP0002249_abnormal_larynx_morphology0.57408183
127MP0000343_altered_response_to0.57093697
128MP0009780_abnormal_chondrocyte_physiolo0.55932245
129MP0003075_altered_response_to0.55822715
130MP0003385_abnormal_body_wall0.55775897
131MP0002254_reproductive_system_inflammat0.54868330
132MP0003795_abnormal_bone_structure0.54336421
133MP0001881_abnormal_mammary_gland0.54306900
134MP0004130_abnormal_muscle_cell0.53650963
135MP0002113_abnormal_skeleton_development0.53323002
136MP0005385_cardiovascular_system_phenoty0.53147111
137MP0001544_abnormal_cardiovascular_syste0.53147111
138MP0009053_abnormal_anal_canal0.52988535
139MP0010386_abnormal_urinary_bladder0.52965647
140MP0000613_abnormal_salivary_gland0.52841052
141MP0000432_abnormal_head_morphology0.52472109
142MP0001664_abnormal_digestion0.52452783
143MP0001915_intracranial_hemorrhage0.52443384
144MP0004084_abnormal_cardiac_muscle0.52194921
145MP0001764_abnormal_homeostasis0.50011077
146MP0000477_abnormal_intestine_morphology0.49405847
147MP0004134_abnormal_chest_morphology0.48664304
148MP0002078_abnormal_glucose_homeostasis0.48618821
149MP0003172_abnormal_lysosome_physiology0.47378367
150MP0002932_abnormal_joint_morphology0.46528317
151MP0003690_abnormal_glial_cell0.46514634
152MP0005448_abnormal_energy_balance0.46035972
153MP0001944_abnormal_pancreas_morphology0.44204492
154MP0005187_abnormal_penis_morphology0.44008638
155MP0004947_skin_inflammation0.43845770
156MP0003436_decreased_susceptibility_to0.43488041
157MP0006082_CNS_inflammation0.43439897
158MP0002653_abnormal_ependyma_morphology0.43281849
159MP0000230_abnormal_systemic_arterial0.42701164
160MP0002557_abnormal_social/conspecific_i0.42470878

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.86893108
2Testicular atrophy (HP:0000029)6.10745315
3Premature rupture of membranes (HP:0001788)6.05441071
4Ankle contracture (HP:0006466)4.50844994
5Abnormality of secondary sexual hair (HP:0009888)4.46388262
6Abnormality of the axillary hair (HP:0100134)4.46388262
7Calf muscle hypertrophy (HP:0008981)4.44807433
8Broad face (HP:0000283)4.34748246
9Prostate neoplasm (HP:0100787)4.27966346
10Flat acetabular roof (HP:0003180)4.09348751
11Intrahepatic cholestasis (HP:0001406)4.09155917
12Deep venous thrombosis (HP:0002625)4.03194538
13Aortic dissection (HP:0002647)3.89396238
14Muscle hypertrophy of the lower extremities (HP:0008968)3.84834924
15Gonadotropin excess (HP:0000837)3.84329052
16Neonatal short-limb short stature (HP:0008921)3.81907103
17Abnormality of the 1st metacarpal (HP:0010009)3.81580728
18Broad metatarsal (HP:0001783)3.79263452
19Mitral stenosis (HP:0001718)3.74417934
20Hypoglycemic coma (HP:0001325)3.72501333
21Abnormality of carpal bone ossification (HP:0006257)3.72074020
22Cervical subluxation (HP:0003308)3.68399899
23Xanthomatosis (HP:0000991)3.59268758
24Follicular hyperkeratosis (HP:0007502)3.54914784
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.51291494
26Short 1st metacarpal (HP:0010034)3.51291494
27Sparse lateral eyebrow (HP:0005338)3.47505851
28Type 1 muscle fiber predominance (HP:0003803)3.42341370
29Spinal rigidity (HP:0003306)3.41927244
30Soft skin (HP:0000977)3.41158723
31Abnormality of the distal phalanx of the thumb (HP:0009617)3.35060365
32Increased connective tissue (HP:0009025)3.34792972
33Wrist flexion contracture (HP:0001239)3.33913087
34Obstructive sleep apnea (HP:0002870)3.27143756
35Abnormality of the phalanges of the hallux (HP:0010057)3.25144186
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.22261500
37Complement deficiency (HP:0004431)3.18367774
38Abnormal ossification of hand bones (HP:0005921)3.17290453
39Peritonitis (HP:0002586)3.13875719
40Overgrowth (HP:0001548)3.13592638
41Atrophic scars (HP:0001075)3.11511093
42Hypoglycemic seizures (HP:0002173)3.09891350
43Short nail (HP:0001799)3.06850250
44Aortic aneurysm (HP:0004942)3.05240439
45Abnormal hand bone ossification (HP:0010660)3.04037724
46Short phalanx of the thumb (HP:0009660)3.03102171
47Abnormal tarsal ossification (HP:0008369)3.03054471
48Cerebral aneurysm (HP:0004944)2.95446677
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92020945
50Biconcave vertebral bodies (HP:0004586)2.91128588
51Abnormality of the common coagulation pathway (HP:0010990)2.88089267
52Fragile skin (HP:0001030)2.79181010
53Abnormality of the Achilles tendon (HP:0005109)2.77456157
54Azoospermia (HP:0000027)2.74885877
55Abnormality of the intrinsic pathway (HP:0010989)2.74353047
56Vertebral compression fractures (HP:0002953)2.73918719
57Abnormality of complement system (HP:0005339)2.72616821
58Amyloidosis (HP:0011034)2.71747622
59Right ventricular cardiomyopathy (HP:0011663)2.70861779
60Achilles tendon contracture (HP:0001771)2.70337741
61Abnormality of the fingertips (HP:0001211)2.69155024
62Shallow orbits (HP:0000586)2.68552794
63Round ear (HP:0100830)2.68320163
64Mildly elevated creatine phosphokinase (HP:0008180)2.66141614
65Myocardial infarction (HP:0001658)2.65041858
66Thin bony cortex (HP:0002753)2.62747005
67Abnormality of the distal phalanges of the toes (HP:0010182)2.62675666
68Bladder diverticulum (HP:0000015)2.61884846
69Hepatocellular carcinoma (HP:0001402)2.61869745
70Dilatation of the ascending aorta (HP:0005111)2.61685926
71Ileus (HP:0002595)2.61184038
72Mitral valve prolapse (HP:0001634)2.60160736
73Abnormal delivery (HP:0001787)2.59850045
74Prolonged partial thromboplastin time (HP:0003645)2.59737153
75Testicular neoplasm (HP:0010788)2.58727220
76Blue sclerae (HP:0000592)2.58638961
77Hyperglycemia (HP:0003074)2.57406668
78Hyperinsulinemic hypoglycemia (HP:0000825)2.56720328
79Hypoalphalipoproteinemia (HP:0003233)2.55486326
80Hypobetalipoproteinemia (HP:0003563)2.54750439
81Ketoacidosis (HP:0001993)2.53124849
82Skin nodule (HP:0200036)2.52128835
83Wormian bones (HP:0002645)2.51310793
84Abnormality of dentin (HP:0010299)2.44736683
85Hypolipoproteinemia (HP:0010981)2.43787492
86Premature skin wrinkling (HP:0100678)2.41802316
87Congenital glaucoma (HP:0001087)2.41596308
88Nonimmune hydrops fetalis (HP:0001790)2.41580812
89Bronchomalacia (HP:0002780)2.38746272
90Polycythemia (HP:0001901)2.38471882
91Slender build (HP:0001533)2.37794289
92Persistence of primary teeth (HP:0006335)2.37588697
93Abnormality of the acetabulum (HP:0003170)2.30636312
94Alopecia of scalp (HP:0002293)2.30124603
95Abnormality of the proximal phalanges of the hand (HP:0009834)2.28925124
96Bulbar palsy (HP:0001283)2.28810796
97Symptomatic seizures (HP:0011145)2.28171868
98Neonatal hypoglycemia (HP:0001998)2.27783269
99Generalized amyotrophy (HP:0003700)2.26689397
100Advanced eruption of teeth (HP:0006288)2.26172636
101Abnormal foot bone ossification (HP:0010675)2.25981878
102Ectopia lentis (HP:0001083)2.25350895
103Ketosis (HP:0001946)2.23120701
104Bifid scrotum (HP:0000048)2.22680582
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21872563
106Neonatal death (HP:0003811)2.21849545
107Coxa vara (HP:0002812)2.21686842
108Growth hormone excess (HP:0000845)2.21667494
109Cardiovascular calcification (HP:0011915)2.20811848
110Osteolytic defects of the hand bones (HP:0009699)2.20701671
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.20701671
112Joint laxity (HP:0001388)2.20397663
113Pancreatic islet-cell hyperplasia (HP:0004510)2.20287768
114Atelectasis (HP:0100750)2.20151623
115Flattened epiphyses (HP:0003071)2.18538451
116Hyperlipoproteinemia (HP:0010980)2.17503315
117Partial duplication of thumb phalanx (HP:0009944)2.16809313
118Fat malabsorption (HP:0002630)2.15236232
119Aneurysm (HP:0002617)2.14434863
120Abnormal cartilage morphology (HP:0002763)2.14043111
121Epidermoid cyst (HP:0200040)2.11241540
122Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.10387154
123Long palpebral fissure (HP:0000637)2.09988120
124Aplasia/hypoplasia of the femur (HP:0005613)2.08804738
125Partial duplication of the phalanx of hand (HP:0009999)2.05643261
126Insulin resistance (HP:0000855)2.05636005
127Systemic lupus erythematosus (HP:0002725)2.03707753
128Bowed forearm bones (HP:0003956)2.01859347
129Bowing of the arm (HP:0006488)2.01859347
130Long eyelashes (HP:0000527)2.00640658
131Radial bowing (HP:0002986)1.99876423
132Anal stenosis (HP:0002025)1.99016932
133Hyperextensible skin (HP:0000974)1.98653162
134Disproportionate tall stature (HP:0001519)1.97615972
135Septate vagina (HP:0001153)1.96899996
136Abnormality of the parathyroid morphology (HP:0011766)1.96565587
137Severe short stature (HP:0003510)1.95250935
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94782900
139Esophageal varix (HP:0002040)1.93382640
140Conjugated hyperbilirubinemia (HP:0002908)1.92277663
141Osteoarthritis (HP:0002758)1.92028022
142Joint stiffness (HP:0001387)1.91108735
143Increased variability in muscle fiber diameter (HP:0003557)1.90849540
144Spinal cord compression (HP:0002176)1.87576392
145Striae distensae (HP:0001065)1.87492413
146Abnormality of the calf musculature (HP:0001430)1.86975165
147Beaking of vertebral bodies (HP:0004568)1.86151235
148Hypoplasia of the odontoid process (HP:0003311)1.85763394
149Axonal loss (HP:0003447)1.85654025
150Tibial bowing (HP:0002982)1.85493294
151Abnormality of endocrine pancreas physiology (HP:0012093)1.85250890
152Abnormality of the pancreatic islet cells (HP:0006476)1.85250890
153Abnormality of fatty-acid metabolism (HP:0004359)1.85132212
154Lower limb hyperreflexia (HP:0002395)1.85036719
155Hyperpituitarism (HP:0010514)1.84810049
156Myokymia (HP:0002411)1.83739347
157Joint hemorrhage (HP:0005261)1.83693950
158Ulnar bowing (HP:0003031)1.83240547
159Gastrointestinal dysmotility (HP:0002579)1.81984351
160Genu recurvatum (HP:0002816)1.81601741
161Insulin-resistant diabetes mellitus (HP:0000831)1.81032181
162Elbow flexion contracture (HP:0002987)1.79558611
163Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.78563609
164Esophageal neoplasm (HP:0100751)1.78175055
165Neoplasm of head and neck (HP:0012288)1.78175055
166Narrow palate (HP:0000189)1.75834630
167Hyperbilirubinemia (HP:0002904)1.75717945
168Patent foramen ovale (HP:0001655)1.75169777
169Impaired smooth pursuit (HP:0007772)1.74091771
170Abnormality of the prostate (HP:0008775)1.73171919
171Protuberant abdomen (HP:0001538)1.72881742
172Vascular tortuosity (HP:0004948)1.72721056
173Hyperammonemia (HP:0001987)1.72278686
174Inguinal hernia (HP:0000023)1.70731266
175Laryngomalacia (HP:0001601)1.70139301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G5.41277314
2TAOK15.29751884
3TNK25.10701691
4INSRR5.10505415
5ERN14.09109695
6PDGFRA3.43477013
7AKT32.97401920
8TRIB32.84738978
9BCKDK2.78102582
10TGFBR22.73117544
11DDR22.56712885
12SIK12.45801843
13TRPM72.43379049
14TIE12.31951470
15PIK3CG2.22504470
16FGFR42.22320123
17MAPK152.19174688
18MARK22.15180662
19TTN2.07642816
20SMG12.06206400
21EPHA31.95111589
22MYLK1.93482864
23MAP3K31.81975520
24FLT31.76148121
25PKN21.66294739
26MET1.65933830
27ERBB31.63244801
28IRAK31.58364090
29EPHB21.51355510
30PTK61.46555217
31TAOK31.46168114
32MST1R1.45708350
33FER1.44625961
34LATS21.41947989
35FRK1.41787937
36PAK21.41665611
37TESK21.40873547
38ARAF1.37367716
39TGFBR11.31562517
40PRKCI1.29906366
41EPHB11.29253478
42PTK21.26738457
43ICK1.26686946
44LATS11.26683911
45RIPK41.22492336
46CDK121.19362642
47PIK3CA1.13940034
48NEK91.11564034
49MAP3K101.10713028
50RIPK11.10540242
51IRAK21.00543933
52TESK10.97620615
53LRRK20.97525558
54RPS6KA40.95433624
55PDGFRB0.95024268
56CSK0.93608824
57EPHA20.92139336
58MAP3K110.91915080
59KDR0.91836792
60MAP2K10.91199409
61RAF10.90580334
62SCYL20.89944633
63PIM20.86077436
64NME20.84900463
65MAP2K20.84370609
66ACVR1B0.83390542
67ZAK0.82610848
68NLK0.81879050
69BMX0.81829422
70CAMK10.77248730
71PRKAA20.75806050
72MOS0.74904158
73PAK30.72944119
74JAK30.72370990
75NTRK10.71840011
76MAP4K10.71062785
77ROCK10.69812284
78BRAF0.68558360
79JAK10.68107150
80MAPKAPK30.67747466
81MAP3K20.66772146
82EEF2K0.66682464
83DAPK30.65698734
84PTK2B0.64848457
85PRKAA10.63104900
86PRKD30.62348924
87DAPK20.58038181
88CDK70.57471790
89PDK20.57085502
90GSK3A0.56908705
91MAPK110.56354560
92CDC42BPA0.56332145
93MTOR0.54986591
94PRKCH0.54799403
95ILK0.54719164
96GRK10.54364317
97ERBB40.54052102
98ABL20.52727341
99GRK70.50087569
100JAK20.49212877
101TYK20.48689037
102DYRK1B0.48672756
103PRKD10.48505008
104SGK4940.47908768
105SGK2230.47908768
106MAP3K10.47557887
107MAPKAPK20.46630897
108PDPK10.46482319
109RPS6KB20.45937426
110STK380.45630705
111RPS6KA20.44585267
112PINK10.42728060
113STK38L0.42625293
114CAMK1D0.42166351
115PRKCZ0.41498649
116MAP2K30.41198467
117IRAK40.40699696
118IGF1R0.40389034
119WNK10.40115521
120MINK10.38592872
121STK30.38096770
122STK110.38080376
123HIPK20.37598970
124PAK40.36892946
125CAMKK10.36792283
126PRKD20.35770853
127MAP3K130.35365079
128ERBB20.32162522
129PLK20.31975104
130LIMK10.31913605
131GRK50.30815785
132RET0.30613871
133PRKG20.30566839
134CAMKK20.30124811
135GRK60.30076498
136FGFR30.28792878
137CAMK2G0.28600721
138INSR0.28550932
139STK100.28496324
140CDK60.27603535
141MAPK120.27281879
142SGK30.27254617
143AURKA0.25336096
144RPS6KC10.22340088
145RPS6KL10.22340088
146PDK10.21745778
147MAPK80.21734293
148CDK90.19676128
149MAPK100.18038909
150PRPF4B0.16535199
151MAP3K70.16425903
152CHUK0.16408617
153TAOK20.14729073
154RPS6KA60.13745670
155AKT10.12481533
156MAP3K80.11962283
157SGK20.11285306
158WNK40.10548363
159GSK3B0.10074333
160MAP3K60.08944980

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.76568757
2Renin-angiotensin system_Homo sapiens_hsa046143.47356442
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16948568
4Complement and coagulation cascades_Homo sapiens_hsa046102.78437979
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.65305361
6Fatty acid degradation_Homo sapiens_hsa000712.52993010
7Tryptophan metabolism_Homo sapiens_hsa003802.46842796
8Nitrogen metabolism_Homo sapiens_hsa009102.41207602
9ECM-receptor interaction_Homo sapiens_hsa045122.29312712
10Sulfur metabolism_Homo sapiens_hsa009202.26085704
11Prostate cancer_Homo sapiens_hsa052152.19663672
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14515440
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07516069
14Caffeine metabolism_Homo sapiens_hsa002322.01609101
15PPAR signaling pathway_Homo sapiens_hsa033201.95378243
16Notch signaling pathway_Homo sapiens_hsa043301.92775159
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92455743
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88831657
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88823027
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.88775101
21Peroxisome_Homo sapiens_hsa041461.85195813
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82807063
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81802368
24Arginine biosynthesis_Homo sapiens_hsa002201.80948138
25Starch and sucrose metabolism_Homo sapiens_hsa005001.77964172
26Chemical carcinogenesis_Homo sapiens_hsa052041.74149431
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68567560
28Fatty acid metabolism_Homo sapiens_hsa012121.68457338
29Propanoate metabolism_Homo sapiens_hsa006401.60701373
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55668613
31Protein digestion and absorption_Homo sapiens_hsa049741.51594529
32Other glycan degradation_Homo sapiens_hsa005111.45971887
33Histidine metabolism_Homo sapiens_hsa003401.38911236
34Selenocompound metabolism_Homo sapiens_hsa004501.36629242
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.36541440
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36504338
37Retinol metabolism_Homo sapiens_hsa008301.36102863
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33843934
39Butanoate metabolism_Homo sapiens_hsa006501.32832156
40beta-Alanine metabolism_Homo sapiens_hsa004101.30537734
41Fat digestion and absorption_Homo sapiens_hsa049751.27373385
42Acute myeloid leukemia_Homo sapiens_hsa052211.27135243
43Glutathione metabolism_Homo sapiens_hsa004801.22861582
44Amoebiasis_Homo sapiens_hsa051461.22291828
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22163828
46Focal adhesion_Homo sapiens_hsa045101.20303536
47Staphylococcus aureus infection_Homo sapiens_hsa051501.16721162
48Galactose metabolism_Homo sapiens_hsa000521.13147329
49ABC transporters_Homo sapiens_hsa020101.12346433
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10406392
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10002992
52Bile secretion_Homo sapiens_hsa049761.08093673
53Pyruvate metabolism_Homo sapiens_hsa006201.07285639
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06907542
55Glucagon signaling pathway_Homo sapiens_hsa049221.05501993
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02615385
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.02442907
58Type II diabetes mellitus_Homo sapiens_hsa049301.02014422
59Prion diseases_Homo sapiens_hsa050201.01100511
60Phenylalanine metabolism_Homo sapiens_hsa003601.00343869
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99760625
62mTOR signaling pathway_Homo sapiens_hsa041500.99743579
63Arginine and proline metabolism_Homo sapiens_hsa003300.98049864
64Tyrosine metabolism_Homo sapiens_hsa003500.98041405
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97947473
66Endometrial cancer_Homo sapiens_hsa052130.95049824
67Folate biosynthesis_Homo sapiens_hsa007900.93579336
68Renin secretion_Homo sapiens_hsa049240.92425789
69Lysine degradation_Homo sapiens_hsa003100.92246192
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92024423
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.90828360
72Carbon metabolism_Homo sapiens_hsa012000.89841765
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88820603
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88039060
75Protein export_Homo sapiens_hsa030600.86377994
76Cholinergic synapse_Homo sapiens_hsa047250.85657563
77Estrogen signaling pathway_Homo sapiens_hsa049150.85436732
78Fatty acid elongation_Homo sapiens_hsa000620.84460962
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81542772
80Sulfur relay system_Homo sapiens_hsa041220.79875148
81Chronic myeloid leukemia_Homo sapiens_hsa052200.79075724
82Bladder cancer_Homo sapiens_hsa052190.78921313
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77881835
84Vitamin digestion and absorption_Homo sapiens_hsa049770.76935996
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76165765
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76041643
87Insulin resistance_Homo sapiens_hsa049310.75775248
88GnRH signaling pathway_Homo sapiens_hsa049120.75604199
89VEGF signaling pathway_Homo sapiens_hsa043700.75208160
90Malaria_Homo sapiens_hsa051440.74619099
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.74358814
92Choline metabolism in cancer_Homo sapiens_hsa052310.70401657
93Vibrio cholerae infection_Homo sapiens_hsa051100.70166497
94Thyroid cancer_Homo sapiens_hsa052160.70010833
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69180770
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68207730
97Platelet activation_Homo sapiens_hsa046110.67948369
98Steroid biosynthesis_Homo sapiens_hsa001000.65594424
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65146701
100One carbon pool by folate_Homo sapiens_hsa006700.64655427
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64475587
102Dilated cardiomyopathy_Homo sapiens_hsa054140.63093310
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.62773851
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61972536
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.59751404
106Pathways in cancer_Homo sapiens_hsa052000.59401879
107Gap junction_Homo sapiens_hsa045400.58999090
108Melanoma_Homo sapiens_hsa052180.58192561
109Proteoglycans in cancer_Homo sapiens_hsa052050.57605552
110Melanogenesis_Homo sapiens_hsa049160.57243088
111Biosynthesis of amino acids_Homo sapiens_hsa012300.56507507
112Small cell lung cancer_Homo sapiens_hsa052220.55661722
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55328110
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55264587
115Rap1 signaling pathway_Homo sapiens_hsa040150.54423420
116Mineral absorption_Homo sapiens_hsa049780.54085165
117Non-small cell lung cancer_Homo sapiens_hsa052230.52758506
118Lysosome_Homo sapiens_hsa041420.50755064
119Thyroid hormone synthesis_Homo sapiens_hsa049180.49983529
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48780086
121Adherens junction_Homo sapiens_hsa045200.48625424
122Serotonergic synapse_Homo sapiens_hsa047260.48373727
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48072463
124Hepatitis C_Homo sapiens_hsa051600.48052741
125Pentose phosphate pathway_Homo sapiens_hsa000300.47752882
126Long-term depression_Homo sapiens_hsa047300.47610259
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.47400808
128Glioma_Homo sapiens_hsa052140.47196362
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46379651
130Arachidonic acid metabolism_Homo sapiens_hsa005900.44503146
131ErbB signaling pathway_Homo sapiens_hsa040120.44363426
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.44314872
133Long-term potentiation_Homo sapiens_hsa047200.43276867
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42453431
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40888857
136Ovarian steroidogenesis_Homo sapiens_hsa049130.39636449
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.39086926
138N-Glycan biosynthesis_Homo sapiens_hsa005100.39085232
139TGF-beta signaling pathway_Homo sapiens_hsa043500.38969565
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.38274160
141Tight junction_Homo sapiens_hsa045300.37304129
142Fructose and mannose metabolism_Homo sapiens_hsa000510.36611509
143Renal cell carcinoma_Homo sapiens_hsa052110.36126982
144cAMP signaling pathway_Homo sapiens_hsa040240.36000384
145FoxO signaling pathway_Homo sapiens_hsa040680.35612970
146Dopaminergic synapse_Homo sapiens_hsa047280.35588131
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35238238
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32631238
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28882876
150Metabolic pathways_Homo sapiens_hsa011000.23879388
151Fatty acid biosynthesis_Homo sapiens_hsa000610.23816991
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22877480
153AMPK signaling pathway_Homo sapiens_hsa041520.22257593
154Glycerolipid metabolism_Homo sapiens_hsa005610.19668051
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19604622
156Insulin signaling pathway_Homo sapiens_hsa049100.18906675
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18251367

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