SPOPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.28025605
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.08143588
3macrophage activation involved in immune response (GO:0002281)4.93543431
4detection of external biotic stimulus (GO:0098581)4.61133404
5regulation of DNA endoreduplication (GO:0032875)4.49882968
6cellular extravasation (GO:0045123)4.49041690
7detection of other organism (GO:0098543)4.48141954
8mitotic sister chromatid cohesion (GO:0007064)4.35823991
9microglial cell activation (GO:0001774)4.34037857
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31291427
11response to peptidoglycan (GO:0032494)4.29997344
12regulation of interferon-beta biosynthetic process (GO:0045357)4.28158174
13histone H3-K36 demethylation (GO:0070544)4.15386160
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.11103850
15histone H3-K4 trimethylation (GO:0080182)4.04840813
16macrophage activation (GO:0042116)4.03852265
17hepatocyte apoptotic process (GO:0097284)4.03245633
18nuclear pore complex assembly (GO:0051292)4.00445729
19detection of biotic stimulus (GO:0009595)3.97109686
20neutrophil activation (GO:0042119)3.93558921
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.91592878
22production of molecular mediator involved in inflammatory response (GO:0002532)3.83401060
23detection of bacterium (GO:0016045)3.80380566
24negative regulation of cell killing (GO:0031342)3.65143472
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65143472
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63253304
27neutrophil mediated immunity (GO:0002446)3.59027815
28regulation of gamma-delta T cell activation (GO:0046643)3.56616112
29nuclear pore organization (GO:0006999)3.53424023
30regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.50834958
31granulocyte activation (GO:0036230)3.48321562
32positive regulation of gamma-delta T cell activation (GO:0046645)3.47729159
33B cell receptor signaling pathway (GO:0050853)3.42356345
34cytoplasmic mRNA processing body assembly (GO:0033962)3.36907344
35negative regulation of interleukin-12 production (GO:0032695)3.36771879
36myeloid cell activation involved in immune response (GO:0002275)3.36025238
37iron ion import (GO:0097286)3.34029790
38histone H3-K4 methylation (GO:0051568)3.32353646
39pore complex assembly (GO:0046931)3.31721789
40peptidyl-lysine trimethylation (GO:0018023)3.28265253
41negative regulation of granulocyte differentiation (GO:0030853)3.20312844
42antigen processing and presentation of endogenous antigen (GO:0019883)3.15699598
43positive regulation of interferon-alpha production (GO:0032727)3.15367315
44replicative senescence (GO:0090399)3.15234771
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.14801862
46positive regulation of cellular amide metabolic process (GO:0034250)3.14440046
47modulation by symbiont of host immune response (GO:0052553)3.13638831
48positive regulation by symbiont of host defense response (GO:0052509)3.13638831
49modulation by symbiont of host defense response (GO:0052031)3.13638831
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13638831
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13638831
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.13638831
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13563654
54regulation of gamma-delta T cell differentiation (GO:0045586)3.12161603
55interferon-gamma secretion (GO:0072643)3.11470849
56phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.06601212
57positive T cell selection (GO:0043368)3.04021050
58leukocyte migration involved in inflammatory response (GO:0002523)3.00771426
59response to interleukin-15 (GO:0070672)2.99624754
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98957603
61myeloid leukocyte mediated immunity (GO:0002444)2.98064517
62monoubiquitinated protein deubiquitination (GO:0035520)2.96327757
63histone H3-K9 demethylation (GO:0033169)2.95043893
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.93351077
65regulation of translation, ncRNA-mediated (GO:0045974)2.93351077
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93351077
67regulation of mast cell degranulation (GO:0043304)2.92802035
68histone mRNA catabolic process (GO:0071044)2.91742583
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90211672
70interkinetic nuclear migration (GO:0022027)2.89278973
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88368826
72DNA strand renaturation (GO:0000733)2.87726609
73regulation of leukocyte degranulation (GO:0043300)2.86243019
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86161395
75regulation of interferon-alpha production (GO:0032647)2.84743213
76germinal center formation (GO:0002467)2.84366097
77histone H3-K9 methylation (GO:0051567)2.83915019
78cellular response to ethanol (GO:0071361)2.81504695
79positive regulation of mast cell activation (GO:0033005)2.79125580
80leukocyte aggregation (GO:0070486)2.79086019
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78600016
82positive thymic T cell selection (GO:0045059)2.78116683
83regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77244696
84ganglion development (GO:0061548)2.76749070
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76623835
86negative regulation of B cell proliferation (GO:0030889)2.76495835
87respiratory burst (GO:0045730)2.76483758
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75974756
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75580771
90negative regulation of T-helper cell differentiation (GO:0045623)2.75580771
91regulation of mast cell activation involved in immune response (GO:0033006)2.75227550
92B cell homeostasis (GO:0001782)2.74066357
93positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73547731
94antigen processing and presentation via MHC class Ib (GO:0002475)2.73166251
95positive regulation of regulated secretory pathway (GO:1903307)2.73006700
96sister chromatid cohesion (GO:0007062)2.72005225
97regulation of necroptotic process (GO:0060544)2.71906882
98regulation of protein polyubiquitination (GO:1902914)2.70607023
99prostate gland growth (GO:0060736)2.70462718
100histone lysine methylation (GO:0034968)2.69265102
101interferon-gamma production (GO:0032609)2.68761179
102histone lysine demethylation (GO:0070076)2.67022136
103regulation of mast cell activation (GO:0033003)2.65859371
104regulation of regulated secretory pathway (GO:1903305)2.65821190
105regulation of interleukin-8 biosynthetic process (GO:0045414)2.64977362
106early endosome to late endosome transport (GO:0045022)2.64052387
107regulation of T-helper 2 cell differentiation (GO:0045628)2.63997530
108immunoglobulin mediated immune response (GO:0016064)2.63853530
109regulation of interleukin-6 biosynthetic process (GO:0045408)2.62562728
110embryonic process involved in female pregnancy (GO:0060136)2.62194694
111hypotonic response (GO:0006971)2.61473774
112cytokine secretion (GO:0050663)2.60796332
113regulation of macrophage cytokine production (GO:0010935)2.59880691
114leukocyte degranulation (GO:0043299)2.59699775
115negative regulation of leukocyte mediated immunity (GO:0002704)2.59588216
116regulation of germinal center formation (GO:0002634)2.58600138
117histone demethylation (GO:0016577)2.58202554
118T-helper 1 type immune response (GO:0042088)2.57906961
119positive regulation of leukocyte degranulation (GO:0043302)2.57576324
120kinetochore organization (GO:0051383)2.55480214
121B cell proliferation (GO:0042100)2.54826769
122megakaryocyte development (GO:0035855)2.54146996
123negative regulation of T cell mediated immunity (GO:0002710)2.53900757
124regulation of DNA-dependent DNA replication (GO:0090329)2.53442044
125myeloid leukocyte activation (GO:0002274)2.52921289
126regulation of platelet aggregation (GO:0090330)2.52747584
127histone H3-K9 modification (GO:0061647)2.52495848
128negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.50328986
129cellular response to interleukin-15 (GO:0071350)2.50268915
130negative regulation of mast cell activation (GO:0033004)2.49358411
131meiotic chromosome segregation (GO:0045132)2.48795986
132response to host immune response (GO:0052572)2.47473793
133response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47473793
134fibroblast migration (GO:0010761)2.43403942
135I-kappaB phosphorylation (GO:0007252)2.41013245
136regulation of histone H3-K27 methylation (GO:0061085)2.39504147
137positive regulation of interleukin-1 beta secretion (GO:0050718)2.38961762
138response to host (GO:0075136)2.33897917
139response to host defenses (GO:0052200)2.33897917
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33897917
141peptidyl-lysine methylation (GO:0018022)2.33347328
142regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32101952
143microtubule anchoring (GO:0034453)2.31909409
144definitive hemopoiesis (GO:0060216)2.31736158
145neural tube formation (GO:0001841)2.30858630
146detection of molecule of bacterial origin (GO:0032490)2.30423146
147NIK/NF-kappaB signaling (GO:0038061)2.30294604
148regulation of granulocyte differentiation (GO:0030852)2.29082583
149modulation by symbiont of host cellular process (GO:0044068)2.28258041
150regulation of helicase activity (GO:0051095)2.28055135
151regulation of B cell receptor signaling pathway (GO:0050855)2.27674295
152positive regulation of granulocyte differentiation (GO:0030854)2.26001683
153embryonic camera-type eye morphogenesis (GO:0048596)2.23793215
154positive regulation of DNA-dependent DNA replication (GO:2000105)2.23109554
155positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.22947008
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.22897793
157protein dealkylation (GO:0008214)2.22750490
158protein demethylation (GO:0006482)2.22750490
159regulation of telomere maintenance (GO:0032204)2.22651910
160positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.21265184
161RNA-dependent DNA replication (GO:0006278)2.18757594
162N-terminal protein amino acid acetylation (GO:0006474)2.18127332
163dosage compensation (GO:0007549)2.17959797
164dendritic cell migration (GO:0036336)2.16749160
165protein localization to microtubule cytoskeleton (GO:0072698)2.16446903
166positive regulation of mRNA catabolic process (GO:0061014)2.15909212
167CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.15785697
168T-helper cell differentiation (GO:0042093)2.15785697
169kinetochore assembly (GO:0051382)2.15509688
170positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.14875560
171positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.14875560
172positive regulation of mitotic sister chromatid separation (GO:1901970)2.14875560
173telomere maintenance via telomerase (GO:0007004)2.13763151
174DNA synthesis involved in DNA repair (GO:0000731)2.13719733
175smooth muscle tissue development (GO:0048745)2.12519879
176response to X-ray (GO:0010165)2.11927463
177DNA damage induced protein phosphorylation (GO:0006975)2.10717023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.70425375
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.30927663
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27269383
4E2F7_22180533_ChIP-Seq_HELA_Human3.25991912
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16621233
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02976901
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96844934
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91872369
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.80494495
10GBX2_23144817_ChIP-Seq_PC3_Human2.69344697
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69028180
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68198377
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.51297903
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45273456
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29836304
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.27621665
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.22962932
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21140629
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20264484
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16249945
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05826401
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04083832
23SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03415382
24NFE2_27457419_Chip-Seq_LIVER_Mouse2.00150291
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97986893
26IGF1R_20145208_ChIP-Seq_DFB_Human1.97778946
27GATA1_22025678_ChIP-Seq_K562_Human1.96972415
28SPI1_23547873_ChIP-Seq_NB4_Human1.87014323
29VDR_24787735_ChIP-Seq_THP-1_Human1.86868059
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84169074
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.84025842
32EWS_26573619_Chip-Seq_HEK293_Human1.82876025
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81697615
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81041544
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.77592394
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77157112
37SPI1_23127762_ChIP-Seq_K562_Human1.76516164
38MYB_26560356_Chip-Seq_TH2_Human1.72476011
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72269152
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71834316
41* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71392832
42FUS_26573619_Chip-Seq_HEK293_Human1.66642161
43* NANOG_18555785_Chip-Seq_ESCs_Mouse1.66497268
44* E2F1_18555785_Chip-Seq_ESCs_Mouse1.62496723
45* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60381597
46MYB_26560356_Chip-Seq_TH1_Human1.58820096
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57057385
48SCL_19346495_ChIP-Seq_HPC-7_Human1.56551151
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55595795
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54825798
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54423287
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54309206
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52990273
54VDR_24763502_ChIP-Seq_THP-1_Human1.52788465
55* P53_22387025_ChIP-Seq_ESCs_Mouse1.52215472
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51547740
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51448140
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50869720
59PU_27001747_Chip-Seq_BMDM_Mouse1.49730934
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48652012
61TP53_16413492_ChIP-PET_HCT116_Human1.47894382
62* P300_19829295_ChIP-Seq_ESCs_Human1.47689175
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47291212
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.44677663
65* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44209059
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43289572
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42584914
68* STAT3_18555785_Chip-Seq_ESCs_Mouse1.42345972
69TAF15_26573619_Chip-Seq_HEK293_Human1.42315791
70* CMYC_18555785_Chip-Seq_ESCs_Mouse1.42236480
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.41228082
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39461429
73STAT3_23295773_ChIP-Seq_U87_Human1.39069740
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37430864
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.37426853
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.37266791
77SMAD4_21799915_ChIP-Seq_A2780_Human1.36854106
78* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35556481
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.35005331
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34882224
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.33703831
82P300_18555785_Chip-Seq_ESCs_Mouse1.32762901
83* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32267899
84* OCT4_18555785_Chip-Seq_ESCs_Mouse1.32117316
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.31765361
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.31082298
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.30630818
88BRD4_25478319_ChIP-Seq_HGPS_Human1.29766728
89TCF7_22412390_ChIP-Seq_EML_Mouse1.28775035
90PU1_27457419_Chip-Seq_LIVER_Mouse1.27228400
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26824325
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26578414
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25451401
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25169114
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24823276
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24504554
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23747283
98* SOX2_18555785_Chip-Seq_ESCs_Mouse1.23664245
99ER_23166858_ChIP-Seq_MCF-7_Human1.23356846
100TCF4_23295773_ChIP-Seq_U87_Human1.23168336
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22968083
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22655524
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22655524
104GATA3_27048872_Chip-Seq_THYMUS_Human1.22354843
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21843326
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21632432
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21334952
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20964606
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20752862
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20095262
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.19444635
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.17434279
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16750198
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16459044
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16252708
116* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15338398
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15011401
118TP53_18474530_ChIP-ChIP_U2OS_Human1.14322666
119CTCF_18555785_Chip-Seq_ESCs_Mouse1.14081818
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12896182
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12328246
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.11968653
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.11600284
124LXR_22158963_ChIP-Seq_LIVER_Mouse1.11451409
125FOXA2_19822575_ChIP-Seq_HepG2_Human1.11121938
126GATA2_19941826_ChIP-Seq_K562_Human1.09364223
127* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09270991
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.09151859
129RUNX_20019798_ChIP-Seq_JUKART_Human1.08905021
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07501022
131* KLF4_18555785_Chip-Seq_ESCs_Mouse1.07490289
132MAF_26560356_Chip-Seq_TH1_Human1.07454343
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06829856
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06785597
135* TP63_23658742_ChIP-Seq_EP156T_Human1.06751391
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06291828
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06291828
138* GATA3_26560356_Chip-Seq_TH2_Human1.05130398
139NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03831664
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03831664
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03711662
142SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01658204
143AHR_22903824_ChIP-Seq_MCF-7_Human1.01550825
144CJUN_26792858_Chip-Seq_BT549_Human1.01509546
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01029753
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00297191
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99727323
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99546922
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99154712
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98698490
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98153731
152SOX2_20726797_ChIP-Seq_SW620_Human0.98107261
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97282829
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.96966193
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96199935
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95780317
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.93907583
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92543273
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92348260
160ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91125371
161AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87626356
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87428180
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86339905
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83489368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.41570352
2MP0003724_increased_susceptibility_to3.98843534
3MP0010234_abnormal_vibrissa_follicle3.60153490
4MP0001188_hyperpigmentation2.96667445
5MP0003303_peritoneal_inflammation2.70896875
6MP0003787_abnormal_imprinting2.64865821
7MP0002396_abnormal_hematopoietic_system2.62251669
8MP0002009_preneoplasia2.55941567
9MP0003436_decreased_susceptibility_to2.53421918
10MP0003191_abnormal_cellular_cholesterol2.52910359
11MP0000015_abnormal_ear_pigmentation2.47289086
12MP0005451_abnormal_body_composition2.43954304
13MP0000566_synostosis2.12490136
14MP0009697_abnormal_copulation2.11082979
15MP0002166_altered_tumor_susceptibility2.05969729
16MP0002006_tumorigenesis2.04637037
17MP0004381_abnormal_hair_follicle2.01263427
18MP0005174_abnormal_tail_pigmentation2.00779119
19MP0003941_abnormal_skin_development1.98275897
20MP0005464_abnormal_platelet_physiology1.97389970
21MP0010307_abnormal_tumor_latency1.94589023
22MP0005076_abnormal_cell_differentiation1.92347387
23MP0009785_altered_susceptibility_to1.88792178
24MP0003172_abnormal_lysosome_physiology1.88326245
25MP0002877_abnormal_melanocyte_morpholog1.86044204
26MP0005025_abnormal_response_to1.85496053
27MP0004883_abnormal_blood_vessel1.82549423
28MP0000685_abnormal_immune_system1.82132318
29MP0004264_abnormal_extraembryonic_tissu1.81481218
30MP0005171_absent_coat_pigmentation1.79422332
31MP0004808_abnormal_hematopoietic_stem1.76409609
32MP0003656_abnormal_erythrocyte_physiolo1.69469061
33MP0000465_gastrointestinal_hemorrhage1.66569062
34MP0001835_abnormal_antigen_presentation1.64088700
35MP0008058_abnormal_DNA_repair1.63420324
36MP0010094_abnormal_chromosome_stability1.63397537
37MP0003183_abnormal_peptide_metabolism1.62117283
38MP0005248_abnormal_Harderian_gland1.59708154
39MP0000371_diluted_coat_color1.59597254
40MP0004947_skin_inflammation1.57535818
41MP0005310_abnormal_salivary_gland1.57052280
42MP0003763_abnormal_thymus_physiology1.55123359
43MP0003121_genomic_imprinting1.53259733
44MP0003045_fibrosis1.51372720
45MP0000427_abnormal_hair_cycle1.50553530
46MP0003111_abnormal_nucleus_morphology1.48238782
47MP0010352_gastrointestinal_tract_polyps1.45385642
48MP0005164_abnormal_response_to1.41803811
49MP0002138_abnormal_hepatobiliary_system1.41770996
50MP0002095_abnormal_skin_pigmentation1.40893404
51MP0006082_CNS_inflammation1.40671358
52MP0008438_abnormal_cutaneous_collagen1.39879681
53MP0002132_abnormal_respiratory_system1.39413392
54MP0001533_abnormal_skeleton_physiology1.38604572
55MP0001845_abnormal_inflammatory_respons1.36722710
56MP0000383_abnormal_hair_follicle1.36363760
57MP0003252_abnormal_bile_duct1.36184572
58MP0008057_abnormal_DNA_replication1.32600346
59MP0010155_abnormal_intestine_physiology1.31224393
60MP0003890_abnormal_embryonic-extraembry1.31115987
61MP0002405_respiratory_system_inflammati1.29114512
62MP0001186_pigmentation_phenotype1.27019971
63MP0002148_abnormal_hypersensitivity_rea1.26196313
64MP0005503_abnormal_tendon_morphology1.22185667
65MP0006054_spinal_hemorrhage1.21531144
66MP0003866_abnormal_defecation1.21450219
67MP0008007_abnormal_cellular_replicative1.21367858
68MP0001851_eye_inflammation1.20986283
69MP0003300_gastrointestinal_ulcer1.20475842
70MP0005671_abnormal_response_to1.18466421
71MP0000490_abnormal_crypts_of1.17893520
72MP0001800_abnormal_humoral_immune1.17384620
73MP0000689_abnormal_spleen_morphology1.17055788
74MP0005409_darkened_coat_color1.16864135
75MP0005257_abnormal_intraocular_pressure1.16624636
76MP0002722_abnormal_immune_system1.15449606
77MP0001790_abnormal_immune_system1.14178901
78MP0005387_immune_system_phenotype1.14178901
79MP0008004_abnormal_stomach_pH1.12202300
80MP0002075_abnormal_coat/hair_pigmentati1.12123019
81MP0001545_abnormal_hematopoietic_system1.11694624
82MP0005397_hematopoietic_system_phenotyp1.11694624
83MP0002928_abnormal_bile_duct1.11067133
84MP0002177_abnormal_outer_ear1.08998067
85MP0000767_abnormal_smooth_muscle1.06186844
86MP0002452_abnormal_antigen_presenting1.06088541
87MP0004484_altered_response_of1.05953675
88MP0003221_abnormal_cardiomyocyte_apopto1.04612616
89MP0003453_abnormal_keratinocyte_physiol1.03901018
90MP0003091_abnormal_cell_migration1.03860514
91MP0002429_abnormal_blood_cell1.03781866
92MP0003943_abnormal_hepatobiliary_system1.01876242
93MP0004134_abnormal_chest_morphology0.96957538
94MP0002398_abnormal_bone_marrow0.95789789
95MP0001915_intracranial_hemorrhage0.94187772
96MP0003690_abnormal_glial_cell0.94077138
97MP0002796_impaired_skin_barrier0.93115717
98MP0002419_abnormal_innate_immunity0.92932840
99MP0003077_abnormal_cell_cycle0.92799135
100MP0001177_atelectasis0.91903433
101MP0001879_abnormal_lymphatic_vessel0.90511960
102MP0000703_abnormal_thymus_morphology0.89845095
103MP0001819_abnormal_immune_cell0.89456139
104MP0001119_abnormal_female_reproductive0.88842077
105MP0000858_altered_metastatic_potential0.88655708
106MP0010678_abnormal_skin_adnexa0.88375791
107MP0002420_abnormal_adaptive_immunity0.88283183
108MP0000733_abnormal_muscle_development0.88249490
109MP0002168_other_aberrant_phenotype0.88009122
110MP0004782_abnormal_surfactant_physiolog0.87856877
111MP0002723_abnormal_immune_serum0.87527193
112MP0003937_abnormal_limbs/digits/tail_de0.86838534
113MP0008469_abnormal_protein_level0.86454540
114MP0002998_abnormal_bone_remodeling0.86348753
115MP0003935_abnormal_craniofacial_develop0.86233890
116MP0002109_abnormal_limb_morphology0.86006243
117MP0001873_stomach_inflammation0.85905582
118MP0002060_abnormal_skin_morphology0.85532086
119MP0005058_abnormal_lysosome_morphology0.84698861
120MP0005075_abnormal_melanosome_morpholog0.84209413
121MP0001853_heart_inflammation0.83078366
122MP0001346_abnormal_lacrimal_gland0.82749545
123MP0001293_anophthalmia0.82395962
124MP0003075_altered_response_to0.81205663
125MP0005408_hypopigmentation0.79437887
126MP0009115_abnormal_fat_cell0.78280045
127MP0002277_abnormal_respiratory_mucosa0.78231561
128MP0005367_renal/urinary_system_phenotyp0.77524037
129MP0000516_abnormal_urinary_system0.77524037
130MP0000432_abnormal_head_morphology0.77185359
131MP0005166_decreased_susceptibility_to0.77106535
132MP0009764_decreased_sensitivity_to0.76346755
133MP0003828_pulmonary_edema0.75321525
134MP0008877_abnormal_DNA_methylation0.73685058
135MP0009703_decreased_birth_body0.73621969
136MP0000716_abnormal_immune_system0.73272489
137MP0001299_abnormal_eye_distance/0.71556380
138MP0004185_abnormal_adipocyte_glucose0.71537707
139MP0003448_altered_tumor_morphology0.70993426
140MP0005275_abnormal_skin_tensile0.70941968
141MP0001191_abnormal_skin_condition0.70670899
142MP0008260_abnormal_autophagy0.70605391
143MP0010386_abnormal_urinary_bladder0.70521590
144MP0009333_abnormal_splenocyte_physiolog0.69989023
145MP0005000_abnormal_immune_tolerance0.69435193
146MP0000627_abnormal_mammary_gland0.69285449
147MP0000609_abnormal_liver_physiology0.68279319
148MP0004510_myositis0.68176608
149MP0006292_abnormal_olfactory_placode0.67756864
150MP0003566_abnormal_cell_adhesion0.67202800
151MP0001175_abnormal_lung_morphology0.66896752
152MP0003705_abnormal_hypodermis_morpholog0.66702945
153MP0004130_abnormal_muscle_cell0.65331481
154MP0005621_abnormal_cell_physiology0.64441638

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.41458712
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17930220
3Chromsome breakage (HP:0040012)4.05826132
4Abnormality of the fingertips (HP:0001211)4.05759012
5Recurrent gram-negative bacterial infections (HP:0005420)3.94587367
6Abnormality of macrophages (HP:0004311)3.94211594
7Prostate neoplasm (HP:0100787)3.68343920
8Gingival bleeding (HP:0000225)3.49713631
9Gastrointestinal infarctions (HP:0005244)3.40097761
10Recurrent skin infections (HP:0001581)3.21892101
11Lip pit (HP:0100267)3.19058478
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.18289434
13Abnormality of the nasal septum (HP:0000419)2.97341909
14Testicular neoplasm (HP:0010788)2.92805269
15Spontaneous hematomas (HP:0007420)2.89951186
16Keratoconjunctivitis (HP:0001096)2.86227816
17Mediastinal lymphadenopathy (HP:0100721)2.80450881
18Prolonged bleeding time (HP:0003010)2.80401742
19Optic neuritis (HP:0100653)2.76235126
20Retrobulbar optic neuritis (HP:0100654)2.76235126
21Protruding tongue (HP:0010808)2.74561298
22Acute myeloid leukemia (HP:0004808)2.74207357
23Stomatitis (HP:0010280)2.72634834
24Peritonitis (HP:0002586)2.72320097
25Volvulus (HP:0002580)2.65387384
26Asymmetry of the thorax (HP:0001555)2.64819811
27Deep philtrum (HP:0002002)2.64815155
28Meningitis (HP:0001287)2.64287294
29Mesomelia (HP:0003027)2.62652970
30Slow saccadic eye movements (HP:0000514)2.61833192
31Vasculitis (HP:0002633)2.61386254
32Generalized hypopigmentation of hair (HP:0011358)2.54547944
33Viral hepatitis (HP:0006562)2.53821929
34Abnormality of chromosome stability (HP:0003220)2.53416813
35Chest pain (HP:0100749)2.48020678
36Neoplasm of the adrenal cortex (HP:0100641)2.46167325
37Bell-shaped thorax (HP:0001591)2.45194172
38Epistaxis (HP:0000421)2.44039514
39Fair hair (HP:0002286)2.43041745
40Urticaria (HP:0001025)2.39381140
41Thyroid carcinoma (HP:0002890)2.36867895
42Abnormality of incisor morphology (HP:0011063)2.36683405
43Micronodular cirrhosis (HP:0001413)2.35774556
44Syringomyelia (HP:0003396)2.35542040
45Spinal cord lesions (HP:0100561)2.35542040
46Pulmonary infiltrates (HP:0002113)2.34291204
47Absent frontal sinuses (HP:0002688)2.33764510
48Long eyelashes (HP:0000527)2.32344303
49Neoplasm of the tracheobronchial system (HP:0100552)2.30894836
50Alveolar cell carcinoma (HP:0006519)2.30284263
51Curly hair (HP:0002212)2.29938246
52Hemoptysis (HP:0002105)2.29708208
53Pulmonary embolism (HP:0002204)2.27953651
54Ectopic kidney (HP:0000086)2.27912250
55Osteomyelitis (HP:0002754)2.26898826
56Encephalitis (HP:0002383)2.24426145
57Inflammation of the large intestine (HP:0002037)2.23330856
58Obstructive lung disease (HP:0006536)2.22435533
59Chronic obstructive pulmonary disease (HP:0006510)2.22435533
60Gangrene (HP:0100758)2.22396501
61Renal cortical cysts (HP:0000803)2.21794226
62Amyloidosis (HP:0011034)2.20788525
63Abnormality of DNA repair (HP:0003254)2.20575861
64Abnormality of the common coagulation pathway (HP:0010990)2.19031636
65Episodic fever (HP:0001954)2.18381299
66T lymphocytopenia (HP:0005403)2.17947884
67Resting tremor (HP:0002322)2.16430449
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.13743915
69Abnormality of T cell number (HP:0011839)2.12152127
70Cellulitis (HP:0100658)2.11640800
71Orchitis (HP:0100796)2.10955696
72Increased IgE level (HP:0003212)2.08939114
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.08643393
74Febrile seizures (HP:0002373)2.06030746
75Gastrointestinal inflammation (HP:0004386)2.05696184
76Abnormality of the prostate (HP:0008775)2.05345121
77Abnormality of the peritoneum (HP:0002585)2.05180867
78Truncal obesity (HP:0001956)2.04619074
79Midline defect of the nose (HP:0004122)2.03108552
80Elevated erythrocyte sedimentation rate (HP:0003565)2.02947495
81Abnormality of the right ventricle (HP:0001707)2.02525571
82Chronic mucocutaneous candidiasis (HP:0002728)2.02186676
83Recurrent cutaneous fungal infections (HP:0011370)2.02186676
84Abnormality of the preputium (HP:0100587)2.01967324
85Abnormal platelet volume (HP:0011876)1.99637406
86Stomach cancer (HP:0012126)1.98835761
87Clubbing of toes (HP:0100760)1.98222346
88Bladder carcinoma (HP:0002862)1.98181015
89Bladder neoplasm (HP:0009725)1.98181015
90Short 4th metacarpal (HP:0010044)1.97280295
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97280295
92Narrow palate (HP:0000189)1.97279203
93Hypoplastic labia majora (HP:0000059)1.96702302
94Colitis (HP:0002583)1.96461710
95Thyroiditis (HP:0100646)1.96051568
96Abnormality of the endocardium (HP:0004306)1.95148809
97Malnutrition (HP:0004395)1.94740883
98Papillary thyroid carcinoma (HP:0002895)1.94673947
99Heterotopia (HP:0002282)1.94586991
100Periodontitis (HP:0000704)1.94206022
101Menstrual irregularities (HP:0000858)1.92693540
102Chronic hepatic failure (HP:0100626)1.92486924
103Long clavicles (HP:0000890)1.92478229
104Urethral obstruction (HP:0000796)1.91880259
105Hypoplasia of the maxilla (HP:0000327)1.90447521
106Acute hepatic failure (HP:0006554)1.90050012
107Right ventricular cardiomyopathy (HP:0011663)1.89554038
108Cheilitis (HP:0100825)1.88187661
109Anorexia (HP:0002039)1.86936961
110Recurrent bacterial skin infections (HP:0005406)1.86031238
111Hypoplasia of the thymus (HP:0000778)1.84784221
112Arterial thrombosis (HP:0004420)1.83197296
113Distal lower limb muscle weakness (HP:0009053)1.81969187
114Myocardial infarction (HP:0001658)1.81843257
115Menorrhagia (HP:0000132)1.81681992
116Recurrent abscess formation (HP:0002722)1.81477267
117Hypoplastic ischia (HP:0003175)1.79817225
118Recurrent fungal infections (HP:0002841)1.79725027
119Abnormality of the labia majora (HP:0012881)1.78812112
120Abnormality of T cells (HP:0002843)1.78577224
121Meckel diverticulum (HP:0002245)1.76990480
122Fatigue (HP:0012378)1.76905198
123Macroorchidism (HP:0000053)1.76676996
124Leukocytosis (HP:0001974)1.75424213
125Chronic diarrhea (HP:0002028)1.75384848
126Tubulointerstitial nephritis (HP:0001970)1.74834694
127Thickened calvaria (HP:0002684)1.74716268
128Germ cell neoplasia (HP:0100728)1.74581028
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74496176
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74167880
131Anal stenosis (HP:0002025)1.73961015
132Papilledema (HP:0001085)1.73044703
133Aplasia cutis congenita (HP:0001057)1.72563769
134Inappropriate behavior (HP:0000719)1.72307896
135Glomerulopathy (HP:0100820)1.71967406
136Mitral stenosis (HP:0001718)1.71654982
137Transitional cell carcinoma of the bladder (HP:0006740)1.71470340
138Abnormality of the incisor (HP:0000676)1.71367528
139Gingivitis (HP:0000230)1.70342091
140Disinhibition (HP:0000734)1.70277198
141Absent speech (HP:0001344)1.70059990
142Osteomalacia (HP:0002749)1.69866794
143Autoimmune hemolytic anemia (HP:0001890)1.68760145
144Abnormality of the renal collecting system (HP:0004742)1.68461185
145Acanthocytosis (HP:0001927)1.68311618
146Myelodysplasia (HP:0002863)1.67683180
147Subacute progressive viral hepatitis (HP:0006572)1.66733201
148Abnormality of the renal cortex (HP:0011035)1.66321984
149Submucous cleft hard palate (HP:0000176)1.65875749
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65331415
151Abnormality of the frontal sinuses (HP:0002687)1.64483939
152Hematochezia (HP:0002573)1.64330218
153Smooth philtrum (HP:0000319)1.63404200
154Recurrent viral infections (HP:0004429)1.63357394
155Distal lower limb amyotrophy (HP:0008944)1.61525431
156Myositis (HP:0100614)1.61375902
157Keratoconjunctivitis sicca (HP:0001097)1.61295040
158Abnormality of the ileum (HP:0001549)1.60699623
159Abnormality of the columella (HP:0009929)1.60426399
160Hypochromic microcytic anemia (HP:0004840)1.60371914
161Abnormal hair whorl (HP:0010721)1.59979379
162Tented upper lip vermilion (HP:0010804)1.58902626
163Increased number of teeth (HP:0011069)1.57490748
164Pulmonary artery stenosis (HP:0004415)1.57462946
165Dislocated radial head (HP:0003083)1.56973167
166Prominent nose (HP:0000448)1.55467674
167Microvesicular hepatic steatosis (HP:0001414)1.55325820
168Progressive hearing impairment (HP:0001730)1.54694671
169Widely spaced teeth (HP:0000687)1.53867354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.74714807
2FRK3.09099592
3BRD42.97706175
4BLK2.95596350
5CDK122.90597878
6LATS12.67275353
7MAP3K22.50615816
8FGR2.16786536
9MAP3K142.13153140
10MAP2K32.12879782
11EPHA32.11879305
12TXK2.03614250
13SGK22.02269925
14NUAK11.95487565
15FGFR31.86343579
16MST41.84561550
17INSRR1.80047862
18JAK31.78480297
19EIF2AK21.68898564
20ERBB31.68101833
21TRPM71.67593204
22IRAK31.63171366
23BMPR1B1.61681501
24IRAK41.61388788
25STK31.61350845
26YES11.59168423
27NEK91.58485806
28JAK11.57062386
29CAMK1D1.56978655
30GRK61.53292347
31PRPF4B1.52160065
32CDK31.50249997
33KSR21.47638068
34SGK31.46203793
35ACVR1B1.45984973
36MAP4K11.40396554
37TAOK31.37406310
38MAP3K31.36416889
39MAP3K11.36255843
40IRAK21.34776086
41ZAP701.30409929
42CHUK1.30341337
43ATR1.29523614
44SRPK11.29428877
45BTK1.27176490
46JAK21.26003903
47STK41.22679947
48TEC1.21473327
49CAMK1G1.18787221
50PLK41.16790667
51RIPK11.16619694
52KIT1.15742149
53FGFR41.13512826
54PKN21.12550270
55CDK91.12514640
56TRIB31.10201787
57EPHB11.08031028
58IKBKE1.07989647
59KSR11.06771964
60FGFR21.06716846
61FES1.04090672
62TYK21.03995628
63CSF1R1.03436727
64CDK61.03067900
65SIK21.02770971
66TTN1.01279163
67RPS6KA41.00930920
68SYK0.99835616
69SIK30.96467912
70LRRK20.96006581
71STK100.94092012
72WNK10.92440721
73PIK3CA0.92231278
74MAP3K120.90338157
75MAP3K130.89954829
76RET0.89728442
77OXSR10.88823729
78PDPK10.88663444
79TAOK10.86304672
80ERN10.85544805
81STK390.85178286
82AKT30.84513824
83ATM0.83535981
84NEK20.83387002
85TGFBR20.82254408
86PDK10.81953024
87STK38L0.80446832
88TAF10.80211850
89PIM10.79320864
90LYN0.79062933
91ITK0.78524547
92MARK30.78290478
93CASK0.77548377
94PTK60.75292179
95IKBKB0.74674682
96PRKAA20.74195063
97SGK2230.73864462
98SGK4940.73864462
99MELK0.73599341
100MAP3K50.73412711
101TNK20.73198789
102IRAK10.72534975
103RPS6KB10.71687757
104RPS6KB20.71364823
105SGK10.71310921
106DMPK0.71142935
107MAP3K60.70620520
108CHEK20.68999288
109EIF2AK30.68692621
110CDC70.68141550
111MATK0.66009778
112PTK2B0.65577961
113RPS6KA50.63561962
114VRK10.61567527
115TTK0.61315095
116HCK0.59787020
117MKNK20.59058256
118PIK3CG0.58184349
119RAF10.57719718
120BMPR20.57148376
121PRKAA10.55868723
122SCYL20.55823284
123STK380.54403166
124PLK30.54376434
125PDGFRB0.54193671
126MAPK70.53078470
127FER0.53048832
128MARK20.50888756
129TBK10.50679910
130FLT30.50439978
131CSK0.49319222
132AURKB0.47629766
133CDK80.46809614
134AKT10.45373478
135STK240.45143569
136IGF1R0.44802071
137TAOK20.43656248
138NEK60.43631773
139HIPK20.43472017
140MAPK130.41048165
141MAPK140.39380313
142LCK0.38146311
143RPS6KA20.38118002
144PRKCQ0.35793718
145PRKCE0.35729787
146RIPK40.35587969
147SIK10.35223768
148NLK0.34704730
149MKNK10.34188055

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.12185843
2Fanconi anemia pathway_Homo sapiens_hsa034602.11239324
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.10532155
4Non-homologous end-joining_Homo sapiens_hsa034501.80094122
5Systemic lupus erythematosus_Homo sapiens_hsa053221.77781864
6Measles_Homo sapiens_hsa051621.70794977
7Legionellosis_Homo sapiens_hsa051341.58013442
8Renal cell carcinoma_Homo sapiens_hsa052111.56197141
9Lysine degradation_Homo sapiens_hsa003101.55521506
10Primary immunodeficiency_Homo sapiens_hsa053401.51422357
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47198661
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44618782
13Graft-versus-host disease_Homo sapiens_hsa053321.43601476
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.43570845
15Homologous recombination_Homo sapiens_hsa034401.39812119
16MicroRNAs in cancer_Homo sapiens_hsa052061.39578602
17Hematopoietic cell lineage_Homo sapiens_hsa046401.37431486
18Small cell lung cancer_Homo sapiens_hsa052221.37279127
19TNF signaling pathway_Homo sapiens_hsa046681.36620347
20p53 signaling pathway_Homo sapiens_hsa041151.36610951
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34507468
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34174722
23Herpes simplex infection_Homo sapiens_hsa051681.34067299
24Influenza A_Homo sapiens_hsa051641.33469212
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29315935
26Osteoclast differentiation_Homo sapiens_hsa043801.25491504
27Thyroid cancer_Homo sapiens_hsa052161.20758761
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18750877
29FoxO signaling pathway_Homo sapiens_hsa040681.16273871
30Adherens junction_Homo sapiens_hsa045201.15958943
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.15194313
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15051881
33Type II diabetes mellitus_Homo sapiens_hsa049301.13367999
34Prostate cancer_Homo sapiens_hsa052151.13259844
35Pancreatic cancer_Homo sapiens_hsa052121.11858479
36Toxoplasmosis_Homo sapiens_hsa051451.10793023
37Viral myocarditis_Homo sapiens_hsa054161.10400505
38B cell receptor signaling pathway_Homo sapiens_hsa046621.08648245
39ErbB signaling pathway_Homo sapiens_hsa040121.07834661
40T cell receptor signaling pathway_Homo sapiens_hsa046601.07182963
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.06693750
42Leishmaniasis_Homo sapiens_hsa051401.05179688
43Hepatitis B_Homo sapiens_hsa051611.04258180
44Inositol phosphate metabolism_Homo sapiens_hsa005621.03946444
45VEGF signaling pathway_Homo sapiens_hsa043701.03453829
46RNA degradation_Homo sapiens_hsa030181.03123127
47Chronic myeloid leukemia_Homo sapiens_hsa052201.02234551
48Allograft rejection_Homo sapiens_hsa053301.00400651
49Prolactin signaling pathway_Homo sapiens_hsa049170.99628533
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.98082849
51HTLV-I infection_Homo sapiens_hsa051660.95969963
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94704312
53Viral carcinogenesis_Homo sapiens_hsa052030.93848123
54Cell cycle_Homo sapiens_hsa041100.93396336
55Endometrial cancer_Homo sapiens_hsa052130.92698679
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92316151
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92259074
58Phagosome_Homo sapiens_hsa041450.91208717
59Tuberculosis_Homo sapiens_hsa051520.90395081
60Apoptosis_Homo sapiens_hsa042100.90286672
61Autoimmune thyroid disease_Homo sapiens_hsa053200.89138418
62mRNA surveillance pathway_Homo sapiens_hsa030150.88753256
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88751376
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88468949
65Colorectal cancer_Homo sapiens_hsa052100.87346307
66Dorso-ventral axis formation_Homo sapiens_hsa043200.85806209
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85433368
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84373093
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83801364
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82995477
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82945292
72Chemokine signaling pathway_Homo sapiens_hsa040620.82665681
73GnRH signaling pathway_Homo sapiens_hsa049120.82242717
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81019079
75HIF-1 signaling pathway_Homo sapiens_hsa040660.80916422
76ECM-receptor interaction_Homo sapiens_hsa045120.80832391
77Melanoma_Homo sapiens_hsa052180.80788004
78One carbon pool by folate_Homo sapiens_hsa006700.79218289
79mTOR signaling pathway_Homo sapiens_hsa041500.78421429
80Acute myeloid leukemia_Homo sapiens_hsa052210.77921120
81Hepatitis C_Homo sapiens_hsa051600.77458426
82TGF-beta signaling pathway_Homo sapiens_hsa043500.76450249
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.76101367
84Focal adhesion_Homo sapiens_hsa045100.75532900
85Ovarian steroidogenesis_Homo sapiens_hsa049130.75447175
86Malaria_Homo sapiens_hsa051440.74723876
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73375612
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73224641
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72127580
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.71714040
91Non-small cell lung cancer_Homo sapiens_hsa052230.71458483
92Complement and coagulation cascades_Homo sapiens_hsa046100.71067400
93Insulin signaling pathway_Homo sapiens_hsa049100.70874353
94Amoebiasis_Homo sapiens_hsa051460.70129320
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70008349
96Insulin resistance_Homo sapiens_hsa049310.69577588
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68603218
98Shigellosis_Homo sapiens_hsa051310.67529635
99Endocytosis_Homo sapiens_hsa041440.66430767
100Proteoglycans in cancer_Homo sapiens_hsa052050.65855608
101Platelet activation_Homo sapiens_hsa046110.65530583
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65180109
103Other glycan degradation_Homo sapiens_hsa005110.64946656
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64766622
105Estrogen signaling pathway_Homo sapiens_hsa049150.63947799
106ABC transporters_Homo sapiens_hsa020100.63598867
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63535842
108Alcoholism_Homo sapiens_hsa050340.63514014
109Antigen processing and presentation_Homo sapiens_hsa046120.63172612
110Choline metabolism in cancer_Homo sapiens_hsa052310.62284650
111Pertussis_Homo sapiens_hsa051330.61594499
112Pathways in cancer_Homo sapiens_hsa052000.59111044
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58671431
114Type I diabetes mellitus_Homo sapiens_hsa049400.58603535
115Base excision repair_Homo sapiens_hsa034100.58225469
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57213317
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56886622
118Salmonella infection_Homo sapiens_hsa051320.56263500
119Circadian rhythm_Homo sapiens_hsa047100.56233469
120Dilated cardiomyopathy_Homo sapiens_hsa054140.56094200
121Glioma_Homo sapiens_hsa052140.55751988
122Sphingolipid metabolism_Homo sapiens_hsa006000.55711658
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54803459
124African trypanosomiasis_Homo sapiens_hsa051430.54385742
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54145053
126MAPK signaling pathway_Homo sapiens_hsa040100.54125275
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51556889
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.51098811
129Long-term potentiation_Homo sapiens_hsa047200.50012982
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49532607
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48272248
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.47766904
133Notch signaling pathway_Homo sapiens_hsa043300.46165692

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