SPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.85791026
2modulation by symbiont of host defense response (GO:0052031)5.85791026
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.85791026
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.85791026
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.85791026
6modulation by symbiont of host immune response (GO:0052553)5.85791026
7glycosphingolipid catabolic process (GO:0046479)5.33098552
8eosinophil chemotaxis (GO:0048245)5.31513854
9cell adhesion mediated by integrin (GO:0033627)5.28695901
10amino sugar catabolic process (GO:0046348)5.01246307
11oligosaccharide catabolic process (GO:0009313)4.97294197
12glycolipid catabolic process (GO:0019377)4.83489575
13cellular response to vitamin D (GO:0071305)4.78679565
14eosinophil migration (GO:0072677)4.72899454
15neutrophil activation involved in immune response (GO:0002283)4.66414396
16regulation of interferon-beta biosynthetic process (GO:0045357)4.62205702
17ceramide catabolic process (GO:0046514)4.48120267
18cellular response to vitamin (GO:0071295)4.34610239
19macrophage activation involved in immune response (GO:0002281)4.23004000
20cellular extravasation (GO:0045123)4.19791732
21macrophage differentiation (GO:0030225)4.07476794
22glucosamine-containing compound catabolic process (GO:1901072)4.05725740
23barbed-end actin filament capping (GO:0051016)4.02916493
24positive regulation of interferon-alpha production (GO:0032727)3.99875097
25wound healing, spreading of epidermal cells (GO:0035313)3.99265291
26monocyte chemotaxis (GO:0002548)3.98569949
27osteoclast differentiation (GO:0030316)3.98178431
28phagocytosis, recognition (GO:0006910)3.93356813
29positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.90119031
30cellular response to ethanol (GO:0071361)3.89987473
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88369846
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.87572658
33response to host immune response (GO:0052572)3.84865620
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84865620
35positive regulation of cellular amide metabolic process (GO:0034250)3.84014979
36ganglioside metabolic process (GO:0001573)3.78061322
37apoptotic cell clearance (GO:0043277)3.77511390
38regulation of interferon-alpha production (GO:0032647)3.77404275
39microglial cell activation (GO:0001774)3.73887759
40regulation of mononuclear cell migration (GO:0071675)3.73396352
41cellular response to zinc ion (GO:0071294)3.68743080
42negative regulation of leukocyte chemotaxis (GO:0002689)3.66754413
43regulation of macrophage chemotaxis (GO:0010758)3.64352405
44negative regulation of interleukin-12 production (GO:0032695)3.64173433
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.63275304
46response to host (GO:0075136)3.63275304
47response to host defenses (GO:0052200)3.63275304
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.60283331
49cellular response to cadmium ion (GO:0071276)3.56924955
50regulation of hypersensitivity (GO:0002883)3.55695833
51response to peptidoglycan (GO:0032494)3.53728204
52membrane lipid catabolic process (GO:0046466)3.49014706
53regulation of integrin-mediated signaling pathway (GO:2001044)3.42584223
54regulation of membrane protein ectodomain proteolysis (GO:0051043)3.42070439
55collagen catabolic process (GO:0030574)3.41956223
56sphingolipid catabolic process (GO:0030149)3.41259897
57collagen metabolic process (GO:0032963)3.40757066
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37062884
59peptide catabolic process (GO:0043171)3.35764896
60cellular response to interferon-alpha (GO:0035457)3.32660013
61chondrocyte proliferation (GO:0035988)3.30252836
62keratan sulfate catabolic process (GO:0042340)3.26224092
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24810376
64skin morphogenesis (GO:0043589)3.24065622
65endodermal cell differentiation (GO:0035987)3.23476356
66adenosine receptor signaling pathway (GO:0001973)3.22454652
67regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.21969196
68regulation of chemokine-mediated signaling pathway (GO:0070099)3.21810441
69wound healing, spreading of cells (GO:0044319)3.18114363
70collagen fibril organization (GO:0030199)3.17990770
71fat-soluble vitamin biosynthetic process (GO:0042362)3.16864479
72multicellular organismal macromolecule metabolic process (GO:0044259)3.14972714
73pinocytosis (GO:0006907)3.13731511
74multicellular organismal catabolic process (GO:0044243)3.13418424
75regulation of vitamin D biosynthetic process (GO:0060556)3.12029042
76* granulocyte chemotaxis (GO:0071621)3.10195504
77regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09530871
78* response to vitamin D (GO:0033280)3.09455136
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09261706
80phagosome maturation (GO:0090382)3.08329534
81negative regulation of myeloid cell apoptotic process (GO:0033033)3.04533616
82regulation of monocyte chemotaxis (GO:0090025)3.02719201
83multicellular organismal metabolic process (GO:0044236)2.99313800
84positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.99118864
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98686686
86macrophage activation (GO:0042116)2.97024857
87* granulocyte migration (GO:0097530)2.96879726
88regulation of lymphocyte chemotaxis (GO:1901623)2.96657723
89myeloid cell homeostasis (GO:0002262)2.95574507
90positive regulation of heat generation (GO:0031652)2.93802537
91N-acetylneuraminate metabolic process (GO:0006054)2.93799584
92positive regulation of antigen processing and presentation (GO:0002579)2.93159218
93response to interferon-alpha (GO:0035455)2.92085524
94positive regulation of mast cell degranulation (GO:0043306)2.92024404
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.92024404
96low-density lipoprotein particle clearance (GO:0034383)2.91433037
97* extracellular matrix disassembly (GO:0022617)2.90913405
98positive regulation of leukocyte degranulation (GO:0043302)2.89902725
99mesenchymal-epithelial cell signaling (GO:0060638)2.89288198
100negative regulation of fatty acid transport (GO:2000192)2.88692088
101COPI coating of Golgi vesicle (GO:0048205)2.87979827
102Golgi transport vesicle coating (GO:0048200)2.87979827
103positive regulation of mast cell activation (GO:0033005)2.85830437
104cytidine catabolic process (GO:0006216)2.85352050
105cytidine deamination (GO:0009972)2.85352050
106cytidine metabolic process (GO:0046087)2.85352050
107* decidualization (GO:0046697)2.85112334
108cellular response to nutrient (GO:0031670)2.84029257
109positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83870382
110regulation of cholesterol storage (GO:0010885)2.83416762
111regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.83366402
112myeloid cell activation involved in immune response (GO:0002275)2.83214715
113I-kappaB phosphorylation (GO:0007252)2.82885337
114positive regulation of chemokine secretion (GO:0090197)2.82676258
115iron ion import (GO:0097286)2.80396937
116regulation of fever generation (GO:0031620)2.79679764
117superoxide anion generation (GO:0042554)2.78270923
118positive regulation of macrophage cytokine production (GO:0060907)2.77736289
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.77681710
120positive regulation of chemokine biosynthetic process (GO:0045080)2.77419677
121histamine secretion (GO:0001821)2.76897717
122intracellular pH reduction (GO:0051452)2.76545396
123regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76107487
124positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75748891
125negative regulation of biomineral tissue development (GO:0070168)2.75345680
126positive regulation of p38MAPK cascade (GO:1900745)2.74492438
127* positive regulation of bone resorption (GO:0045780)2.74213372
128* positive regulation of bone remodeling (GO:0046852)2.74213372
129hyaluronan catabolic process (GO:0030214)2.74111754
130adhesion of symbiont to host cell (GO:0044650)2.73979470
131virion attachment to host cell (GO:0019062)2.73979470
132detection of molecule of bacterial origin (GO:0032490)2.73565346
133respiratory burst (GO:0045730)2.73262004
134* positive regulation of tissue remodeling (GO:0034105)2.72814241
135glucose 6-phosphate metabolic process (GO:0051156)2.72610316
136* neutrophil chemotaxis (GO:0030593)2.71991864
137NADPH regeneration (GO:0006740)2.71923687
138immunoglobulin mediated immune response (GO:0016064)2.70314352
139regulation of monocyte differentiation (GO:0045655)2.68833022
140regulation of inflammatory response to antigenic stimulus (GO:0002861)2.68208916
141myeloid dendritic cell differentiation (GO:0043011)2.68183714
142substrate-dependent cell migration (GO:0006929)2.67794026
143positive regulation of interferon-beta production (GO:0032728)2.67650110
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66763056
145negative regulation of lipid storage (GO:0010888)2.66266234
146positive regulation of acute inflammatory response (GO:0002675)2.66083410
147regulation of macrophage cytokine production (GO:0010935)2.65515132
148response to thyroid hormone (GO:0097066)2.65429911
149* neutrophil migration (GO:1990266)2.65261837
150transferrin transport (GO:0033572)2.65192313
151response to muramyl dipeptide (GO:0032495)2.64584950
152protein heterotrimerization (GO:0070208)2.64578981
153pH reduction (GO:0045851)2.63862634
154ruffle organization (GO:0031529)2.63655708
155T-helper 1 type immune response (GO:0042088)2.63581921
156negative regulation of mast cell activation (GO:0033004)2.63444723
157positive regulation of gamma-delta T cell activation (GO:0046645)2.62889853
158cellular response to thyroid hormone stimulus (GO:0097067)2.62814365
159regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62519938
160positive regulation of phagocytosis (GO:0050766)2.61901155
161natural killer cell mediated cytotoxicity (GO:0042267)2.59922584
162natural killer cell mediated immunity (GO:0002228)2.59922584
163regulation of prostaglandin secretion (GO:0032306)2.59771808
164adhesion of symbiont to host (GO:0044406)2.58944170
165response to manganese ion (GO:0010042)2.58434778
166endothelial cell morphogenesis (GO:0001886)2.57409033
167negative regulation of bone mineralization (GO:0030502)2.57152450
168* myeloid leukocyte migration (GO:0097529)2.57098036
169negative regulation of interleukin-17 production (GO:0032700)2.57048964
170production of molecular mediator involved in inflammatory response (GO:0002532)2.55814839
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.55478846
172axon extension involved in axon guidance (GO:0048846)2.55478846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.82394663
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.55193720
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.35416551
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.89527701
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.70802145
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.54249684
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51015598
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.49362191
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.41195481
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.39572564
11* IRF8_27001747_Chip-Seq_BMDM_Mouse3.02575686
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96582733
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87780187
14CLOCK_20551151_ChIP-Seq_293T_Human2.78239555
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.59834545
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57007526
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39232535
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36320911
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33162921
20* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.27176351
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24530183
22* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14039665
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05957259
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03601058
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.02357381
26CJUN_26792858_Chip-Seq_BT549_Human1.96319138
27GATA1_22025678_ChIP-Seq_K562_Human1.94266226
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92108627
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90929266
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.90210879
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.90210879
32* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82360848
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80779464
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80205898
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79794940
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79794940
37SCL_19346495_ChIP-Seq_HPC-7_Human1.77812212
38SOX2_20726797_ChIP-Seq_SW620_Human1.77790519
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72702596
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71606100
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70622459
42TFEB_21752829_ChIP-Seq_HELA_Human1.64926039
43* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.62336916
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.61355986
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60116870
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.56087638
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50753758
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49687892
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49185961
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.45563091
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41593416
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41082951
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.40455455
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.40057369
55BRD4_25478319_ChIP-Seq_HGPS_Human1.36712750
56ATF3_27146783_Chip-Seq_COLON_Human1.35429564
57VDR_24787735_ChIP-Seq_THP-1_Human1.34608824
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32519760
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30551621
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30101017
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29066831
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25457103
63PU_27001747_Chip-Seq_BMDM_Mouse1.24879827
64* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24306828
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.23917638
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23544395
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23355137
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22965392
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22079898
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21935298
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.19168120
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18802490
73* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18721148
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18442790
75* SPI1_23547873_ChIP-Seq_NB4_Human1.17592592
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16558948
77AR_21909140_ChIP-Seq_LNCAP_Human1.16135754
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14836041
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14047727
80TP53_16413492_ChIP-PET_HCT116_Human1.13749931
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13463365
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12659005
83* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09508561
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09395103
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09369349
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.08090722
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06769531
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06709614
89VDR_24763502_ChIP-Seq_THP-1_Human1.05851981
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05568827
91SPI1_23127762_ChIP-Seq_K562_Human1.04730542
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04722157
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03680291
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03496917
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02996908
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01921752
97RACK7_27058665_Chip-Seq_MCF-7_Human1.01124130
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.01029718
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00632132
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00575728
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00426415
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00052191
103STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99656695
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98902338
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98611979
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98603537
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98316519
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98160076
109GATA4_25053715_ChIP-Seq_YYC3_Human0.96790001
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96549774
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95472969
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94126951
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94007601
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93903911
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93545607
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93166092
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91427706
118RUNX_20019798_ChIP-Seq_JUKART_Human0.90656905
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.89895361
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89429179
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87288299
122GATA1_19941826_ChIP-Seq_K562_Human0.85586815
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84272586
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83056222
125MYB_26560356_Chip-Seq_TH2_Human0.82946160
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82745049
127VDR_21846776_ChIP-Seq_THP-1_Human0.81890649
128KDM2B_26808549_Chip-Seq_K562_Human0.81889676
129TP53_18474530_ChIP-ChIP_U2OS_Human0.80298989
130LXR_22292898_ChIP-Seq_THP-1_Human0.80284163
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80213262
132LXR_22158963_ChIP-Seq_LIVER_Mouse0.80198352
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79357807
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76844366
135GATA2_19941826_ChIP-Seq_K562_Human0.74584581
136STAT1_20625510_ChIP-Seq_HELA_Human0.73779058
137AHR_22903824_ChIP-Seq_MCF-7_Human0.72440980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.09755138
2MP0005058_abnormal_lysosome_morphology3.83711192
3MP0002139_abnormal_hepatobiliary_system3.45673498
4MP0003705_abnormal_hypodermis_morpholog3.22560808
5MP0003436_decreased_susceptibility_to2.91614159
6MP0005167_abnormal_blood-brain_barrier2.75620353
7MP0005275_abnormal_skin_tensile2.66681764
8MP0001958_emphysema2.57338304
9MP0005503_abnormal_tendon_morphology2.52638940
10MP0003300_gastrointestinal_ulcer2.51670742
11MP0003172_abnormal_lysosome_physiology2.44913872
12MP0003279_aneurysm2.36838172
13MP0003303_peritoneal_inflammation2.34884367
14MP0003566_abnormal_cell_adhesion2.30339609
15MP0010352_gastrointestinal_tract_polyps2.25681074
16MP0006082_CNS_inflammation2.18117290
17MP0001533_abnormal_skeleton_physiology2.14984857
18* MP0005023_abnormal_wound_healing2.12706520
19MP0003329_amyloid_beta_deposits2.05645243
20MP0005257_abnormal_intraocular_pressure2.04694146
21MP0005671_abnormal_response_to1.90709193
22MP0010386_abnormal_urinary_bladder1.87315034
23MP0000920_abnormal_myelination1.84177497
24MP0003448_altered_tumor_morphology1.83092143
25* MP0002419_abnormal_innate_immunity1.81965382
26MP0001542_abnormal_bone_strength1.79019761
27* MP0002998_abnormal_bone_remodeling1.78828707
28MP0006054_spinal_hemorrhage1.76632553
29MP0004272_abnormal_basement_membrane1.72409188
30MP0010307_abnormal_tumor_latency1.69476317
31* MP0000343_altered_response_to1.65292214
32MP0002933_joint_inflammation1.64650814
33MP0000604_amyloidosis1.62865067
34MP0009840_abnormal_foam_cell1.61696581
35MP0005365_abnormal_bile_salt1.60487821
36MP0010234_abnormal_vibrissa_follicle1.60062269
37MP0000858_altered_metastatic_potential1.59650254
38MP0005390_skeleton_phenotype1.55810364
39MP0000685_abnormal_immune_system1.55789882
40* MP0002148_abnormal_hypersensitivity_rea1.51022280
41MP0009384_cardiac_valve_regurgitation1.49638423
42* MP0009785_altered_susceptibility_to1.49548471
43* MP0003091_abnormal_cell_migration1.48262615
44MP0001835_abnormal_antigen_presentation1.45402880
45MP0002295_abnormal_pulmonary_circulatio1.45096919
46* MP0002896_abnormal_bone_mineralization1.44675696
47MP0003828_pulmonary_edema1.43973071
48MP0005310_abnormal_salivary_gland1.42378565
49* MP0005000_abnormal_immune_tolerance1.40136426
50MP0005076_abnormal_cell_differentiation1.39818830
51MP0003806_abnormal_nucleotide_metabolis1.37619159
52* MP0001545_abnormal_hematopoietic_system1.37243262
53* MP0005397_hematopoietic_system_phenotyp1.37243262
54* MP0003795_abnormal_bone_structure1.35834796
55MP0000750_abnormal_muscle_regeneration1.33167303
56MP0001881_abnormal_mammary_gland1.33027433
57MP0005623_abnormal_meninges_morphology1.32994164
58MP0005379_endocrine/exocrine_gland_phen1.32703346
59MP0003045_fibrosis1.32677149
60MP0005451_abnormal_body_composition1.32457579
61MP0003656_abnormal_erythrocyte_physiolo1.30929150
62MP0003075_altered_response_to1.30335603
63MP0005166_decreased_susceptibility_to1.29624289
64MP0001800_abnormal_humoral_immune1.28475678
65MP0008260_abnormal_autophagy1.28381982
66MP0004947_skin_inflammation1.28106722
67MP0002277_abnormal_respiratory_mucosa1.27218383
68* MP0005164_abnormal_response_to1.27135480
69* MP0003195_calcinosis1.25309598
70MP0002138_abnormal_hepatobiliary_system1.25069026
71MP0003191_abnormal_cellular_cholesterol1.24872053
72MP0003690_abnormal_glial_cell1.22629386
73MP0002877_abnormal_melanocyte_morpholog1.22112150
74* MP0002168_other_aberrant_phenotype1.21739657
75MP0003453_abnormal_keratinocyte_physiol1.21524796
76MP0005508_abnormal_skeleton_morphology1.21165668
77MP0002837_dystrophic_cardiac_calcinosis1.18171340
78* MP0009278_abnormal_bone_marrow1.14826192
79MP0009764_decreased_sensitivity_to1.12717869
80* MP0005025_abnormal_response_to1.11547449
81MP0003283_abnormal_digestive_organ1.11069956
82MP0002115_abnormal_skeleton_extremities1.10624952
83* MP0002452_abnormal_antigen_presenting1.10589307
84MP0002163_abnormal_gland_morphology1.09406929
85MP0002060_abnormal_skin_morphology1.06000908
86MP0000569_abnormal_digit_pigmentation1.04300212
87MP0005197_abnormal_uvea_morphology1.02570858
88* MP0004883_abnormal_blood_vessel0.99529026
89MP0000733_abnormal_muscle_development0.98407380
90* MP0003634_abnormal_glial_cell0.98398822
91MP0002113_abnormal_skeleton_development0.97790347
92* MP0001845_abnormal_inflammatory_respons0.96939889
93MP0000371_diluted_coat_color0.96114569
94MP0005647_abnormal_sex_gland0.95022048
95MP0005464_abnormal_platelet_physiology0.94230474
96* MP0002136_abnormal_kidney_physiology0.93115123
97MP0002405_respiratory_system_inflammati0.91459459
98MP0001853_heart_inflammation0.90621532
99MP0000767_abnormal_smooth_muscle0.89858516
100MP0000627_abnormal_mammary_gland0.89363327
101MP0001243_abnormal_dermal_layer0.88777896
102MP0003633_abnormal_nervous_system0.87434374
103* MP0008469_abnormal_protein_level0.87039666
104MP0001915_intracranial_hemorrhage0.85903913
105MP0005083_abnormal_biliary_tract0.85637414
106MP0003183_abnormal_peptide_metabolism0.85416571
107MP0000163_abnormal_cartilage_morphology0.84257392
108MP0002090_abnormal_vision0.82533122
109MP0001849_ear_inflammation0.81451182
110MP0004510_myositis0.80891878
111MP0002282_abnormal_trachea_morphology0.80312519
112* MP0002135_abnormal_kidney_morphology0.80135476
113* MP0005595_abnormal_vascular_smooth0.79550811
114* MP0000249_abnormal_blood_vessel0.78180292
115* MP0002723_abnormal_immune_serum0.77121616
116MP0004019_abnormal_vitamin_homeostasis0.76272629
117MP0010155_abnormal_intestine_physiology0.76246419
118MP0001756_abnormal_urination0.75716025
119* MP0009643_abnormal_urine_homeostasis0.75577306
120* MP0009763_increased_sensitivity_to0.74164823
121* MP0001790_abnormal_immune_system0.73971613
122* MP0005387_immune_system_phenotype0.73971613
123MP0003186_abnormal_redox_activity0.73715098
124MP0010678_abnormal_skin_adnexa0.73063104
125MP0001299_abnormal_eye_distance/0.73021653
126* MP0001819_abnormal_immune_cell0.72406689
127* MP0002420_abnormal_adaptive_immunity0.71141319
128MP0003950_abnormal_plasma_membrane0.70493788
129MP0008004_abnormal_stomach_pH0.70350077
130* MP0000716_abnormal_immune_system0.68942671
131MP0009333_abnormal_splenocyte_physiolog0.68098576
132* MP0005165_increased_susceptibility_to0.67724211
133MP0003632_abnormal_nervous_system0.67709429
134MP0003724_increased_susceptibility_to0.67215144
135MP0003631_nervous_system_phenotype0.65603651
136MP0002254_reproductive_system_inflammat0.63724999
137MP0001851_eye_inflammation0.63689098
138MP0003252_abnormal_bile_duct0.62375128
139MP0005171_absent_coat_pigmentation0.58711811
140MP0004233_abnormal_muscle_weight0.57210667

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.03725452
2Vacuolated lymphocytes (HP:0001922)4.87764602
3Increased neuronal autofluorescent lipopigment (HP:0002074)4.67520182
4Protrusio acetabuli (HP:0003179)4.61000178
5Premature rupture of membranes (HP:0001788)4.56424019
6Mutism (HP:0002300)4.52517546
7Cervical subluxation (HP:0003308)4.19600598
8Dysostosis multiplex (HP:0000943)4.17139986
9Neurofibrillary tangles (HP:0002185)3.85887039
10Vertebral compression fractures (HP:0002953)3.81893351
11Urinary glycosaminoglycan excretion (HP:0003541)3.68555388
12Mucopolysacchariduria (HP:0008155)3.68555388
13Axonal loss (HP:0003447)3.60836408
14Upper motor neuron abnormality (HP:0002127)3.56039689
15Metaphyseal irregularity (HP:0003025)3.55203706
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.39370659
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.39370659
18Abnormality of polysaccharide metabolism (HP:0011012)3.39370659
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.34219571
20Complement deficiency (HP:0004431)3.33571522
21Disinhibition (HP:0000734)3.31512373
22Abnormality of glycolipid metabolism (HP:0010969)3.30211290
23Abnormality of liposaccharide metabolism (HP:0010968)3.30211290
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.30211290
25Mediastinal lymphadenopathy (HP:0100721)3.24806255
26Metaphyseal cupping (HP:0003021)3.23862867
27Eczematoid dermatitis (HP:0000976)3.13251675
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07660783
29Osteolytic defects of the phalanges of the hand (HP:0009771)3.06144030
30Osteolytic defects of the hand bones (HP:0009699)3.06144030
31Systemic lupus erythematosus (HP:0002725)3.01553022
32Recurrent abscess formation (HP:0002722)2.97876086
33Nuclear cataract (HP:0100018)2.89626374
34Ankle contracture (HP:0006466)2.89474248
35Amyloidosis (HP:0011034)2.85992880
36Abnormality of macrophages (HP:0004311)2.84330367
37Beaking of vertebral bodies (HP:0004568)2.80544967
38Spondylolisthesis (HP:0003302)2.77692692
39Atrophic scars (HP:0001075)2.75943238
40Peritonitis (HP:0002586)2.72786151
41Cerebral inclusion bodies (HP:0100314)2.71178225
42Cerebral aneurysm (HP:0004944)2.69146949
43Aortic dissection (HP:0002647)2.68557226
44Myocardial infarction (HP:0001658)2.68229379
45Soft skin (HP:0000977)2.64942265
46Arterial tortuosity (HP:0005116)2.63464474
47Neuronal loss in central nervous system (HP:0002529)2.63109399
48Wormian bones (HP:0002645)2.57896870
49Pathologic fracture (HP:0002756)2.56996319
50Xanthomatosis (HP:0000991)2.56585279
51Vascular tortuosity (HP:0004948)2.54105655
52Aortic aneurysm (HP:0004942)2.49730084
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48412164
54Recurrent skin infections (HP:0001581)2.45519866
55Persistence of primary teeth (HP:0006335)2.39052612
56Recurrent gram-negative bacterial infections (HP:0005420)2.39042748
57Coxa vara (HP:0002812)2.38428668
58Cupped ribs (HP:0000887)2.38397910
59Recurrent bacterial skin infections (HP:0005406)2.37959036
60Inappropriate behavior (HP:0000719)2.37844387
61Bone pain (HP:0002653)2.37574761
62Abnormality of complement system (HP:0005339)2.34461091
63Blue sclerae (HP:0000592)2.34356452
64Ovoid vertebral bodies (HP:0003300)2.33514264
65Basal ganglia calcification (HP:0002135)2.31852980
66Hepatosplenomegaly (HP:0001433)2.30774726
67Abnormality of the lumbar spine (HP:0100712)2.30481310
68Hydroxyprolinuria (HP:0003080)2.28594084
69Abnormality of proline metabolism (HP:0010907)2.28594084
70Retinal atrophy (HP:0001105)2.28531218
71Global brain atrophy (HP:0002283)2.26887483
72Dementia (HP:0000726)2.26258334
73Hypoplasia of the odontoid process (HP:0003311)2.25806720
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25428777
75Ulnar bowing (HP:0003031)2.25015863
76Progressive visual loss (HP:0000529)2.24423814
77Purpura (HP:0000979)2.23634721
78Loss of speech (HP:0002371)2.21813798
79Fragile skin (HP:0001030)2.20953338
80Tetraparesis (HP:0002273)2.20506288
81Personality changes (HP:0000751)2.20425188
82Platyspondyly (HP:0000926)2.20049450
83Shallow orbits (HP:0000586)2.19974915
84Absent frontal sinuses (HP:0002688)2.19646613
85Genu recurvatum (HP:0002816)2.19107405
86Mitral stenosis (HP:0001718)2.19099247
87Dilatation of the ascending aorta (HP:0005111)2.18669207
88Progressive neurologic deterioration (HP:0002344)2.17570064
89Increased CSF protein (HP:0002922)2.17253893
90Abnormality of the odontoid process (HP:0003310)2.15285702
91Interstitial pulmonary disease (HP:0006530)2.14730539
92Glomerulonephritis (HP:0000099)2.13522996
93Esophageal neoplasm (HP:0100751)2.13117734
94Neoplasm of head and neck (HP:0012288)2.13117734
95Femoral bowing (HP:0002980)2.12376348
96Abnormality of the periventricular white matter (HP:0002518)2.11719329
97Cardiomegaly (HP:0001640)2.11424439
98Biconcave vertebral bodies (HP:0004586)2.11035891
99Spontaneous hematomas (HP:0007420)2.10878822
100Lymphangioma (HP:0100764)2.10085803
101Joint stiffness (HP:0001387)2.09896042
102Prolonged neonatal jaundice (HP:0006579)2.09233692
103Abnormality of the acetabulum (HP:0003170)2.08643865
104Diminished motivation (HP:0000745)2.05897283
105Hypophosphatemia (HP:0002148)2.04362930
106Thin bony cortex (HP:0002753)2.03925696
107Apathy (HP:0000741)2.03306044
108Increased density of long bones (HP:0006392)2.00431927
109Esophageal varix (HP:0002040)1.99064491
110Exostoses (HP:0100777)1.96764964
111Tibial bowing (HP:0002982)1.96422713
112Peripheral demyelination (HP:0011096)1.95531695
113Autoimmune thrombocytopenia (HP:0001973)1.95073111
114Increased serum ferritin (HP:0003281)1.92895070
115Cardiovascular calcification (HP:0011915)1.92387492
116J-shaped sella turcica (HP:0002680)1.91740675
117Prostate neoplasm (HP:0100787)1.89895505
118Recurrent pneumonia (HP:0006532)1.89777978
119Follicular hyperkeratosis (HP:0007502)1.87515959
120Radial bowing (HP:0002986)1.87460987
121Abnormal cartilage morphology (HP:0002763)1.87375618
122Asymmetric septal hypertrophy (HP:0001670)1.87206566
123Poor head control (HP:0002421)1.86258851
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86078554
125Agnosia (HP:0010524)1.85964317
126Neonatal short-limb short stature (HP:0008921)1.85942683
127Obstructive lung disease (HP:0006536)1.85817517
128Chronic obstructive pulmonary disease (HP:0006510)1.85817517
129Nephritis (HP:0000123)1.85810905
130Pustule (HP:0200039)1.85780362
131Osteomyelitis (HP:0002754)1.85779041
132Gingivitis (HP:0000230)1.84196984
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82726775
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.82269761
135Hematochezia (HP:0002573)1.79856095
136Thoracic kyphosis (HP:0002942)1.79620693
137Multiple enchondromatosis (HP:0005701)1.79324333
138Bladder diverticulum (HP:0000015)1.79207394
139Malnutrition (HP:0004395)1.78229591
140Protuberant abdomen (HP:0001538)1.78149742
141Spinal cord lesions (HP:0100561)1.78116263
142Syringomyelia (HP:0003396)1.78116263
143Mitral valve prolapse (HP:0001634)1.76843136
144Azoospermia (HP:0000027)1.76597105
145Spinal muscular atrophy (HP:0007269)1.72904349
146Supranuclear gaze palsy (HP:0000605)1.72813956
147Irregular vertebral endplates (HP:0003301)1.71790611
148Premature loss of primary teeth (HP:0006323)1.69676850
149Recurrent fungal infections (HP:0002841)1.69090968
150Bone cyst (HP:0012062)1.68580398
151Memory impairment (HP:0002354)1.67605369
152Petechiae (HP:0000967)1.66884038
153Conjunctival telangiectasia (HP:0000524)1.66764982
154Impaired platelet aggregation (HP:0003540)1.65542502
155Abnormal platelet function (HP:0011869)1.65542502
156Hypercholesterolemia (HP:0003124)1.64580628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.87630603
2IRAK33.84011264
3DDR23.23524568
4ERN13.02568145
5PKN22.88397355
6PBK2.86807907
7NME22.80907782
8TRIB32.68857981
9TTN2.58736169
10TBK12.54443038
11EPHA22.26576853
12KIT2.25569980
13SCYL22.19756421
14TGFBR22.15916479
15PDGFRA2.02536841
16LRRK22.01985454
17FGR1.92640306
18PAK41.92141324
19PIM21.91800021
20FRK1.80083658
21TYK21.75619555
22GRK71.73155307
23NEK91.67873572
24MAP3K31.66665359
25EPHB11.63489926
26RIPK11.59508408
27EPHA31.49289766
28BMX1.49039326
29RPS6KA41.46354058
30STK101.43349093
31MOS1.42475977
32MAP3K141.39057206
33PTK61.34010284
34TRPM71.33601031
35FER1.31431471
36TESK11.25218264
37CAMK1D1.24203131
38MST1R1.22359910
39ABL21.21686842
40BLK1.20911954
41CDK61.20244726
42STK31.19680643
43DYRK1B1.17385304
44JAK11.16567205
45ERBB31.13839692
46CDC42BPA1.13329997
47MATK1.11160550
48MST41.08919393
49WNK41.06325994
50PDGFRB1.03766993
51JAK31.00869993
52IKBKB1.00729228
53RIPK41.00658431
54PTK20.96330200
55MET0.95329711
56CAMKK20.94674350
57LATS10.94396756
58MAP2K30.94182668
59ADRBK20.94162794
60PLK20.92017091
61SIK10.91521932
62ZAP700.88661350
63ERBB40.88199673
64CHUK0.85780073
65PDPK10.85240896
66IRAK40.82945194
67HCK0.82297497
68PDK20.79319105
69CSK0.79155083
70MAP3K110.77727131
71FLT30.77529450
72MAP3K10.76332345
73PDK10.76117356
74CAMKK10.74981749
75PIK3CG0.74632573
76MAPK120.73662726
77MAP3K80.73568400
78PAK20.72945198
79FES0.67714261
80SYK0.66567806
81KSR20.66294055
82BMPR20.65631872
83ARAF0.65500028
84EGFR0.65186660
85ABL10.64115953
86MAP3K130.63837747
87FGFR40.63735505
88PRKG20.63517327
89MAP2K10.62781748
90MAP3K20.61897662
91DAPK20.61561577
92MAP3K90.60337192
93ITK0.60270602
94LYN0.59770652
95CSF1R0.58600819
96PRKCQ0.57400541
97RPS6KA20.57119201
98ROCK10.56690614
99MAPK70.56298946
100PRKCD0.55097136
101GSK3A0.54942067
102TAOK30.54344908
103CAMK40.53731524
104PIM10.51890151
105CAMK1G0.51795318
106ACVR1B0.51747517
107NTRK10.51456691
108KSR10.49681362
109FGFR30.49369129
110FGFR10.49014906
111INSR0.48929954
112IKBKE0.48584281
113MAP3K120.46980982
114ROCK20.45528208
115TAOK20.45405244
116JAK20.44927425
117BCR0.44396627
118TGFBR10.43637119
119MAPKAPK20.42915174
120MARK30.42613239
121IGF1R0.42457476
122PKN10.40659531
123LATS20.39847622
124LCK0.39827759
125PRKCH0.39745965
126MAP3K50.39296792
127SRC0.38811073
128SGK30.36502192
129LIMK10.35559484
130MAPK40.35398314
131PAK30.35001433
132TESK20.34099940
133TAOK10.33885397
134PRKACG0.32325536
135EPHB20.31766278
136PRKAA20.31204361
137CAMK2G0.30658399

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041423.80329894
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.50076738
3Malaria_Homo sapiens_hsa051442.75566629
4Phagosome_Homo sapiens_hsa041452.72855003
5Other glycan degradation_Homo sapiens_hsa005112.71710655
6Rheumatoid arthritis_Homo sapiens_hsa053232.50856229
7Staphylococcus aureus infection_Homo sapiens_hsa051502.38174604
8Leishmaniasis_Homo sapiens_hsa051402.36523853
9* ECM-receptor interaction_Homo sapiens_hsa045122.20795205
10Legionellosis_Homo sapiens_hsa051341.91630511
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88770013
12Osteoclast differentiation_Homo sapiens_hsa043801.86847157
13Tuberculosis_Homo sapiens_hsa051521.83463255
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74100152
15Pertussis_Homo sapiens_hsa051331.72842070
16* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70180717
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62910653
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61636892
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.56662197
20TNF signaling pathway_Homo sapiens_hsa046681.54058470
21Proteoglycans in cancer_Homo sapiens_hsa052051.51303211
22* Focal adhesion_Homo sapiens_hsa045101.50572890
23Amoebiasis_Homo sapiens_hsa051461.39044896
24Apoptosis_Homo sapiens_hsa042101.35101529
25Shigellosis_Homo sapiens_hsa051311.34522671
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34474736
27Steroid biosynthesis_Homo sapiens_hsa001001.34285893
28Collecting duct acid secretion_Homo sapiens_hsa049661.34155844
29Bladder cancer_Homo sapiens_hsa052191.32991928
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.30976652
31Antigen processing and presentation_Homo sapiens_hsa046121.30445836
32Salmonella infection_Homo sapiens_hsa051321.28730274
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26528150
34Toxoplasmosis_Homo sapiens_hsa051451.26059132
35Small cell lung cancer_Homo sapiens_hsa052221.24160499
36Pancreatic cancer_Homo sapiens_hsa052121.20079334
37Renin-angiotensin system_Homo sapiens_hsa046141.18086460
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15129118
39Chronic myeloid leukemia_Homo sapiens_hsa052201.13458272
40Mineral absorption_Homo sapiens_hsa049781.09103727
41Vibrio cholerae infection_Homo sapiens_hsa051101.08255673
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07445584
43Allograft rejection_Homo sapiens_hsa053301.06904324
44Sulfur metabolism_Homo sapiens_hsa009201.06550922
45Protein digestion and absorption_Homo sapiens_hsa049741.03278783
46MicroRNAs in cancer_Homo sapiens_hsa052061.02320274
47Complement and coagulation cascades_Homo sapiens_hsa046101.02161854
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01819059
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01672164
50Adherens junction_Homo sapiens_hsa045200.99938385
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.98430834
52Hepatitis B_Homo sapiens_hsa051610.97543281
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93501885
54Measles_Homo sapiens_hsa051620.92798190
55Type I diabetes mellitus_Homo sapiens_hsa049400.91965719
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91388981
57Melanoma_Homo sapiens_hsa052180.90782256
58Caffeine metabolism_Homo sapiens_hsa002320.90073067
59Influenza A_Homo sapiens_hsa051640.89980485
60HIF-1 signaling pathway_Homo sapiens_hsa040660.89129676
61Viral myocarditis_Homo sapiens_hsa054160.88531015
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88157991
63Fructose and mannose metabolism_Homo sapiens_hsa000510.86412312
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84039227
65Sphingolipid metabolism_Homo sapiens_hsa006000.83207664
66Hematopoietic cell lineage_Homo sapiens_hsa046400.82739846
67African trypanosomiasis_Homo sapiens_hsa051430.82661003
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82637521
69PPAR signaling pathway_Homo sapiens_hsa033200.82434703
70Autoimmune thyroid disease_Homo sapiens_hsa053200.78861233
71Synaptic vesicle cycle_Homo sapiens_hsa047210.77108140
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74501020
73B cell receptor signaling pathway_Homo sapiens_hsa046620.73323016
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73010922
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72700669
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.70293082
77Hepatitis C_Homo sapiens_hsa051600.70066055
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68078317
79Glutathione metabolism_Homo sapiens_hsa004800.67829955
80Prion diseases_Homo sapiens_hsa050200.66172543
81Galactose metabolism_Homo sapiens_hsa000520.65367033
82* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64920409
83p53 signaling pathway_Homo sapiens_hsa041150.64429176
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64311887
85TGF-beta signaling pathway_Homo sapiens_hsa043500.60918552
86Prostate cancer_Homo sapiens_hsa052150.60005993
87Viral carcinogenesis_Homo sapiens_hsa052030.59936478
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59587435
89Endocytosis_Homo sapiens_hsa041440.58957029
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55774806
91Platelet activation_Homo sapiens_hsa046110.54250873
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.52358647
93N-Glycan biosynthesis_Homo sapiens_hsa005100.51506928
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51290915
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48434910
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47713356
97Glioma_Homo sapiens_hsa052140.47191158
98Asthma_Homo sapiens_hsa053100.46735377
99Ether lipid metabolism_Homo sapiens_hsa005650.44636393
100Type II diabetes mellitus_Homo sapiens_hsa049300.44542976
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43249578
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42907783
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41862313
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41840816
105Graft-versus-host disease_Homo sapiens_hsa053320.40965822
106VEGF signaling pathway_Homo sapiens_hsa043700.40310996
107Nitrogen metabolism_Homo sapiens_hsa009100.39039858
108Chemokine signaling pathway_Homo sapiens_hsa040620.39003558
109Bile secretion_Homo sapiens_hsa049760.38496148
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38339851
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36514585
112HTLV-I infection_Homo sapiens_hsa051660.36382724
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35702633
114Renal cell carcinoma_Homo sapiens_hsa052110.35690343
115Pentose phosphate pathway_Homo sapiens_hsa000300.34704869
116Herpes simplex infection_Homo sapiens_hsa051680.34539963
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34436672
118Vitamin B6 metabolism_Homo sapiens_hsa007500.34294019
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.33363274
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32674167
121Dilated cardiomyopathy_Homo sapiens_hsa054140.32310591
122Starch and sucrose metabolism_Homo sapiens_hsa005000.27291906
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25553728
124Dorso-ventral axis formation_Homo sapiens_hsa043200.25506755
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.23628385
126GnRH signaling pathway_Homo sapiens_hsa049120.20717247
127Estrogen signaling pathway_Homo sapiens_hsa049150.20655576
128Gastric acid secretion_Homo sapiens_hsa049710.16921899
129Rap1 signaling pathway_Homo sapiens_hsa040150.15090866
130Renin secretion_Homo sapiens_hsa049240.14613443
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14515308
132Pancreatic secretion_Homo sapiens_hsa049720.14337847

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