SPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.44735011
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44735011
3L-phenylalanine metabolic process (GO:0006558)7.18759030
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18759030
5aromatic amino acid family catabolic process (GO:0009074)6.65562983
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.47040015
7glyoxylate metabolic process (GO:0046487)6.21425028
8tryptophan catabolic process (GO:0006569)5.92440601
9indole-containing compound catabolic process (GO:0042436)5.92440601
10indolalkylamine catabolic process (GO:0046218)5.92440601
11high-density lipoprotein particle remodeling (GO:0034375)5.80829239
12kynurenine metabolic process (GO:0070189)5.80342154
13tryptophan metabolic process (GO:0006568)5.62604388
14negative regulation of fibrinolysis (GO:0051918)5.60942560
15bile acid biosynthetic process (GO:0006699)5.57455276
16cysteine metabolic process (GO:0006534)5.46066826
17regulation of fibrinolysis (GO:0051917)5.34808761
18behavioral response to nicotine (GO:0035095)5.33974138
19sulfur amino acid catabolic process (GO:0000098)5.33711015
20urea cycle (GO:0000050)5.32934320
21urea metabolic process (GO:0019627)5.32934320
22alpha-linolenic acid metabolic process (GO:0036109)5.25202289
23reverse cholesterol transport (GO:0043691)5.22644756
24serine family amino acid catabolic process (GO:0009071)5.17588472
25lysine metabolic process (GO:0006553)5.17573403
26lysine catabolic process (GO:0006554)5.17573403
27protein carboxylation (GO:0018214)5.14141503
28peptidyl-glutamic acid carboxylation (GO:0017187)5.14141503
29regulation of cholesterol esterification (GO:0010872)5.06007743
30oxidative demethylation (GO:0070989)4.99239928
31plasma lipoprotein particle remodeling (GO:0034369)4.97205655
32protein-lipid complex remodeling (GO:0034368)4.97205655
33macromolecular complex remodeling (GO:0034367)4.97205655
34nitrogen cycle metabolic process (GO:0071941)4.91071624
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88157680
36aromatic amino acid family metabolic process (GO:0009072)4.86689397
37regulation of protein activation cascade (GO:2000257)4.86425755
38homocysteine metabolic process (GO:0050667)4.85014784
39regulation of triglyceride catabolic process (GO:0010896)4.82523727
40pyrimidine nucleobase catabolic process (GO:0006208)4.79478372
41phospholipid efflux (GO:0033700)4.76136162
42bile acid metabolic process (GO:0008206)4.75382933
43cellular ketone body metabolic process (GO:0046950)4.71495385
44amino-acid betaine metabolic process (GO:0006577)4.70770936
45complement activation, alternative pathway (GO:0006957)4.68765895
46negative regulation of cholesterol transport (GO:0032375)4.66960558
47negative regulation of sterol transport (GO:0032372)4.66960558
48tyrosine metabolic process (GO:0006570)4.65091735
49plasma lipoprotein particle clearance (GO:0034381)4.64486473
50alpha-amino acid catabolic process (GO:1901606)4.61337556
51acylglycerol homeostasis (GO:0055090)4.58503633
52triglyceride homeostasis (GO:0070328)4.58503633
53epoxygenase P450 pathway (GO:0019373)4.52713168
54regulation of complement activation (GO:0030449)4.49276101
55drug catabolic process (GO:0042737)4.34252033
56cholesterol efflux (GO:0033344)4.34176206
57omega-hydroxylase P450 pathway (GO:0097267)4.33846406
58glycine metabolic process (GO:0006544)4.32241944
59glutamate metabolic process (GO:0006536)4.31524604
60serine family amino acid metabolic process (GO:0009069)4.31321059
61cellular amino acid catabolic process (GO:0009063)4.30170852
62plasma lipoprotein particle assembly (GO:0034377)4.25486132
63cellular modified amino acid catabolic process (GO:0042219)4.23118364
64indolalkylamine metabolic process (GO:0006586)4.22219552
65nucleobase catabolic process (GO:0046113)4.15763283
66serine family amino acid biosynthetic process (GO:0009070)4.15521789
67aldehyde catabolic process (GO:0046185)4.14034602
68amine catabolic process (GO:0009310)4.08456829
69cellular biogenic amine catabolic process (GO:0042402)4.08456829
70ketone body metabolic process (GO:1902224)4.07905391
71urate metabolic process (GO:0046415)4.03914021
72benzene-containing compound metabolic process (GO:0042537)4.02093568
73short-chain fatty acid metabolic process (GO:0046459)4.01736055
74dicarboxylic acid biosynthetic process (GO:0043650)4.00495950
75coenzyme catabolic process (GO:0009109)3.98742710
76drug transmembrane transport (GO:0006855)3.96778053
77bile acid and bile salt transport (GO:0015721)3.96315038
78positive regulation of triglyceride lipase activity (GO:0061365)3.95111404
79positive regulation of lipoprotein lipase activity (GO:0051006)3.95111404
80fibrinolysis (GO:0042730)3.93406898
81arginine metabolic process (GO:0006525)3.93212139
82low-density lipoprotein particle remodeling (GO:0034374)3.93006819
83cellular glucuronidation (GO:0052695)3.92920423
84imidazole-containing compound metabolic process (GO:0052803)3.91137934
85ethanol oxidation (GO:0006069)3.88609621
86phospholipid homeostasis (GO:0055091)3.84986371
87aspartate family amino acid catabolic process (GO:0009068)3.84521602
88protein-lipid complex assembly (GO:0065005)3.83371224
89organic acid catabolic process (GO:0016054)3.79895682
90carboxylic acid catabolic process (GO:0046395)3.79895682
91cholesterol homeostasis (GO:0042632)3.79497755
92blood coagulation, intrinsic pathway (GO:0007597)3.79116797
93plasma lipoprotein particle organization (GO:0071827)3.78857241
94drug metabolic process (GO:0017144)3.75456367
95sterol homeostasis (GO:0055092)3.75213033
96positive regulation of lipid catabolic process (GO:0050996)3.75130167
97acetyl-CoA metabolic process (GO:0006084)3.71236465
98lipoprotein metabolic process (GO:0042157)3.68760120
99negative regulation of lipase activity (GO:0060192)3.68581073
1002-oxoglutarate metabolic process (GO:0006103)3.63353904
101regulation of plasminogen activation (GO:0010755)3.63081164
102exogenous drug catabolic process (GO:0042738)3.61998593
103very-low-density lipoprotein particle assembly (GO:0034379)3.58911801
104protein-lipid complex subunit organization (GO:0071825)3.57411739
105glucuronate metabolic process (GO:0019585)3.56148758
106uronic acid metabolic process (GO:0006063)3.56148758
107cofactor catabolic process (GO:0051187)3.56000440
108alkaloid metabolic process (GO:0009820)3.53009374
109response to pheromone (GO:0019236)3.47858952
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44949132
111phenylpropanoid metabolic process (GO:0009698)3.44207089
112S-adenosylmethionine metabolic process (GO:0046500)3.42487122
113gamma-aminobutyric acid transport (GO:0015812)3.34553417
114indole-containing compound metabolic process (GO:0042430)3.29340703
115detection of light stimulus involved in sensory perception (GO:0050962)3.19698110
116detection of light stimulus involved in visual perception (GO:0050908)3.19698110
117flavonoid metabolic process (GO:0009812)3.10574544
118neural tube formation (GO:0001841)3.04524346
119detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95970091
120water-soluble vitamin biosynthetic process (GO:0042364)2.94847538
121epithelial cilium movement (GO:0003351)2.92686460
122arginine catabolic process (GO:0006527)2.91958743
123dopamine transport (GO:0015872)2.88079719
124tachykinin receptor signaling pathway (GO:0007217)2.86520509
125behavioral response to ethanol (GO:0048149)2.83719186
126heme transport (GO:0015886)2.81245234
127amino acid salvage (GO:0043102)2.79393801
128L-methionine salvage (GO:0071267)2.79393801
129L-methionine biosynthetic process (GO:0071265)2.79393801
130synaptic transmission, cholinergic (GO:0007271)2.77193000
131iron coordination entity transport (GO:1901678)2.75101969
132L-fucose metabolic process (GO:0042354)2.74814926
133L-fucose catabolic process (GO:0042355)2.74814926
134fucose catabolic process (GO:0019317)2.74814926
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66921053
136sulfation (GO:0051923)2.66821433
137cilium or flagellum-dependent cell motility (GO:0001539)2.65826997
138positive regulation of fatty acid transport (GO:2000193)2.65507140
139establishment of protein localization to Golgi (GO:0072600)2.60604268
140nonmotile primary cilium assembly (GO:0035058)2.57639163
141photoreceptor cell maintenance (GO:0045494)2.56749339
142disruption of cells of other organism (GO:0044364)2.55966688
143killing of cells of other organism (GO:0031640)2.55966688
144somite development (GO:0061053)2.54045060
145sodium-independent organic anion transport (GO:0043252)2.53496528
146peptidyl-glutamic acid modification (GO:0018200)2.49880268
147NAD biosynthetic process (GO:0009435)2.49703088
148cilium movement (GO:0003341)2.48848417
149parturition (GO:0007567)2.48734489
150axoneme assembly (GO:0035082)2.47971033
151negative regulation of astrocyte differentiation (GO:0048712)2.45139504
152reflex (GO:0060004)2.44665933
153ethanol metabolic process (GO:0006067)2.44130523
154positive regulation of icosanoid secretion (GO:0032305)2.43734221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.32077974
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14748815
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.72464640
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.41542251
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05754881
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05688898
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.98634858
8EZH2_22144423_ChIP-Seq_EOC_Human4.33544077
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92118861
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86505649
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25727635
12VDR_22108803_ChIP-Seq_LS180_Human3.03311277
13GBX2_23144817_ChIP-Seq_PC3_Human2.94710719
14ZNF274_21170338_ChIP-Seq_K562_Hela2.71978135
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54786385
16IGF1R_20145208_ChIP-Seq_DFB_Human2.46979121
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45121781
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34317768
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29385099
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17932021
21TAF15_26573619_Chip-Seq_HEK293_Human2.12211300
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11496630
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09913033
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08099550
25* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8854997
26* P300_19829295_ChIP-Seq_ESCs_Human1.92501463
27ER_23166858_ChIP-Seq_MCF-7_Human1.87554072
28FUS_26573619_Chip-Seq_HEK293_Human1.82716973
29IRF1_19129219_ChIP-ChIP_H3396_Human1.81691187
30REST_21632747_ChIP-Seq_MESCs_Mouse1.72788150
31CLOCK_20551151_ChIP-Seq_293T_Human1.72682653
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71217605
33BCAT_22108803_ChIP-Seq_LS180_Human1.70834122
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.68270790
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67471643
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66948978
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.62891365
38EWS_26573619_Chip-Seq_HEK293_Human1.61597909
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60441171
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.60107556
41STAT3_23295773_ChIP-Seq_U87_Human1.59869068
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58917319
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.58604745
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.57343342
45* FLI1_27457419_Chip-Seq_LIVER_Mouse1.57040370
46CBP_20019798_ChIP-Seq_JUKART_Human1.56856871
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56856871
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52887354
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49808412
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49666328
51TCF4_23295773_ChIP-Seq_U87_Human1.47826450
52HNF4A_19822575_ChIP-Seq_HepG2_Human1.46921004
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46217287
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46217287
55GATA1_22025678_ChIP-Seq_K562_Human1.46137596
56AR_25329375_ChIP-Seq_VCAP_Human1.43662738
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42979032
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39445541
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38524241
60HTT_18923047_ChIP-ChIP_STHdh_Human1.38405696
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37576500
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37095355
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.36489289
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35267789
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35260362
66RNF2_27304074_Chip-Seq_NSC_Mouse1.34855723
67* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33107260
68RUNX2_22187159_ChIP-Seq_PCA_Human1.32718291
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32330880
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30006267
71TCF4_22108803_ChIP-Seq_LS180_Human1.29992739
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28539788
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.27725986
74SOX2_19829295_ChIP-Seq_ESCs_Human1.26770130
75NANOG_19829295_ChIP-Seq_ESCs_Human1.26770130
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26148260
77* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25064721
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22570068
79TP53_22573176_ChIP-Seq_HFKS_Human1.22497602
80* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22364426
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21984245
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21575731
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20725532
84AR_21572438_ChIP-Seq_LNCaP_Human1.18653177
85* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18643469
86* NFE2_27457419_Chip-Seq_LIVER_Mouse1.18470541
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.18021633
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.17389037
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16227943
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.15955017
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15498162
92* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15368502
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.14749063
94* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13813217
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12937176
96* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12819391
97* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12210983
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12181770
99* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11997674
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10438803
101DROSHA_22980978_ChIP-Seq_HELA_Human1.09899604
102* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09858130
103NCOR_22424771_ChIP-Seq_293T_Human1.09350101
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.09258336
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06844792
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06781579
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.06718135
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06667941
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05845352
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05428983
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05298730
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03843105
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03632311
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.03512884
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03379830
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.03379830
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03319077
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02650797
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02406165
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00839085
121TP53_16413492_ChIP-PET_HCT116_Human1.00372576
122* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99418426
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99347541
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99216322
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96243223
126GATA4_25053715_ChIP-Seq_YYC3_Human0.93051593
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87465432
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81877830
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78944510
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.78918680
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78629248
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78400927
133ZNF263_19887448_ChIP-Seq_K562_Human0.78290011
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78062731
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77717144
136IRF8_22096565_ChIP-ChIP_GC-B_Human0.77620743
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.75910759
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74744751
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74215628
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72435238
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.72303897
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72204310
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71668053
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71640230
145EGR1_19032775_ChIP-ChIP_M12_Human0.68806605
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68511364
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68358194
148LXR_22292898_ChIP-Seq_THP-1_Human0.68052550
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67729209
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66956852
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66826214
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59968396
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.59653994
154GATA1_19941826_ChIP-Seq_K562_Human0.57247006
155AR_20517297_ChIP-Seq_VCAP_Human0.56479802
156* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56157581
157* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56157581
158* CEBPB_22108803_ChIP-Seq_LS180_Human0.55652026
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.55154776
160* MYC_19915707_ChIP-ChIP_AK7_Human0.54528699
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53265489
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.52886321
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52513439
164GATA6_25053715_ChIP-Seq_YYC3_Human0.50473260
165* FOXA1_25552417_ChIP-Seq_VCAP_Human0.49997299
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.49385190
167CBP_21632823_ChIP-Seq_H3396_Human0.49247869
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.49158710
169GATA2_19941826_ChIP-Seq_K562_Human0.49153146
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.48776656
171TAF2_19829295_ChIP-Seq_ESCs_Human0.48557857
172PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48129042
173* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45942614
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45882537
175STAT1_17558387_ChIP-Seq_HELA_Human0.45401578
176SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44998791
177P53_21459846_ChIP-Seq_SAOS-2_Human0.44802035
178* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44071372
179PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43269283
180SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42967241
181FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42091893
182SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41893045
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41260248
184* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41171176
185SOX2_20726797_ChIP-Seq_SW620_Human0.40327790
186STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39061283
187GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.38749186
188P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.38417745
189CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38414550
190EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.37329973
191RACK7_27058665_Chip-Seq_MCF-7_Human0.37189416
192MYC_27129775_Chip-Seq_CORNEA_Mouse0.37189324
193CSB_26484114_Chip-Seq_FIBROBLAST_Human0.37129649
194E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37072224
195OCT4_20526341_ChIP-Seq_ESCs_Human0.36586731
196BCOR_27268052_Chip-Seq_Bcells_Human0.36380737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05128509
2MP0005360_urolithiasis7.90744025
3MP0005085_abnormal_gallbladder_physiolo6.01044893
4MP0005365_abnormal_bile_salt5.89339298
5MP0008875_abnormal_xenobiotic_pharmacok4.95570332
6MP0003806_abnormal_nucleotide_metabolis4.02113844
7MP0003252_abnormal_bile_duct3.74837576
8MP0010329_abnormal_lipoprotein_level3.54724331
9MP0009840_abnormal_foam_cell3.33015372
10MP0005332_abnormal_amino_acid3.16126577
11MP0003195_calcinosis3.15423431
12MP0003787_abnormal_imprinting2.85917797
13MP0005083_abnormal_biliary_tract2.83516265
14MP0004019_abnormal_vitamin_homeostasis2.74061354
15MP0003191_abnormal_cellular_cholesterol2.56470755
16MP0006292_abnormal_olfactory_placode2.52967327
17MP0001666_abnormal_nutrient_absorption2.48711401
18MP0000569_abnormal_digit_pigmentation2.32268504
19MP0005551_abnormal_eye_electrophysiolog2.27936820
20MP0002138_abnormal_hepatobiliary_system2.18688769
21MP0008877_abnormal_DNA_methylation2.16727962
22MP0000609_abnormal_liver_physiology2.08281727
23MP0001986_abnormal_taste_sensitivity2.05850410
24MP0002118_abnormal_lipid_homeostasis2.05349564
25MP0004142_abnormal_muscle_tone1.99693566
26MP0006276_abnormal_autonomic_nervous1.98524374
27MP0003646_muscle_fatigue1.97438416
28MP0005646_abnormal_pituitary_gland1.89942857
29MP0001968_abnormal_touch/_nociception1.85734849
30MP0005319_abnormal_enzyme/_coenzyme1.81973696
31MP0009745_abnormal_behavioral_response1.79660278
32MP0002102_abnormal_ear_morphology1.78192866
33MP0001764_abnormal_homeostasis1.74959846
34MP0002163_abnormal_gland_morphology1.71785107
35MP0009643_abnormal_urine_homeostasis1.69469541
36MP0003868_abnormal_feces_composition1.69165714
37MP0005584_abnormal_enzyme/coenzyme_acti1.65804570
38MP0002272_abnormal_nervous_system1.65057894
39MP0003880_abnormal_central_pattern1.63739300
40MP0002736_abnormal_nociception_after1.61166982
41MP0005451_abnormal_body_composition1.59731445
42MP0005423_abnormal_somatic_nervous1.59080340
43MP0003136_yellow_coat_color1.56997172
44MP0009046_muscle_twitch1.56247708
45MP0002638_abnormal_pupillary_reflex1.48320489
46MP0009697_abnormal_copulation1.46814425
47MP0006072_abnormal_retinal_apoptosis1.45546089
48MP0001486_abnormal_startle_reflex1.43199978
49MP0003186_abnormal_redox_activity1.41645382
50MP0005645_abnormal_hypothalamus_physiol1.39036954
51MP0003011_delayed_dark_adaptation1.37760456
52MP0005379_endocrine/exocrine_gland_phen1.37006149
53MP0005253_abnormal_eye_physiology1.36340037
54MP0001984_abnormal_olfaction1.34147169
55MP0003121_genomic_imprinting1.33590632
56MP0004885_abnormal_endolymph1.33295637
57MP0005636_abnormal_mineral_homeostasis1.31975486
58MP0004145_abnormal_muscle_electrophysio1.28818434
59MP0003656_abnormal_erythrocyte_physiolo1.28394102
60MP0002572_abnormal_emotion/affect_behav1.27061133
61MP0001485_abnormal_pinna_reflex1.25734876
62MP0003122_maternal_imprinting1.23914053
63MP0000778_abnormal_nervous_system1.23673226
64MP0003878_abnormal_ear_physiology1.23477574
65MP0005377_hearing/vestibular/ear_phenot1.23477574
66MP0003635_abnormal_synaptic_transmissio1.23062926
67MP0001440_abnormal_grooming_behavior1.20138954
68MP0002064_seizures1.18793117
69MP0000631_abnormal_neuroendocrine_gland1.17810499
70MP0000372_irregular_coat_pigmentation1.17288505
71MP0000598_abnormal_liver_morphology1.16425065
72MP0002653_abnormal_ependyma_morphology1.14878189
73MP0002557_abnormal_social/conspecific_i1.14645598
74MP0000427_abnormal_hair_cycle1.13769957
75MP0000604_amyloidosis1.12991269
76MP0002063_abnormal_learning/memory/cond1.12511055
77MP0001970_abnormal_pain_threshold1.11254226
78MP0010386_abnormal_urinary_bladder1.10902245
79MP0005195_abnormal_posterior_eye1.10601478
80MP0001501_abnormal_sleep_pattern1.10593904
81MP0002733_abnormal_thermal_nociception1.10247834
82MP0003879_abnormal_hair_cell1.08098739
83MP0004133_heterotaxia1.07631849
84MP0004742_abnormal_vestibular_system1.07102533
85MP0005174_abnormal_tail_pigmentation1.05381218
86MP0002067_abnormal_sensory_capabilities1.05061635
87MP0009764_decreased_sensitivity_to1.04461598
88MP0003705_abnormal_hypodermis_morpholog1.02961885
89MP0001756_abnormal_urination1.02417861
90MP0004924_abnormal_behavior1.00638776
91MP0005386_behavior/neurological_phenoty1.00638776
92MP0001905_abnormal_dopamine_level1.00407592
93MP0010368_abnormal_lymphatic_system1.00319033
94MP0004043_abnormal_pH_regulation0.98275771
95MP0005647_abnormal_sex_gland0.96077877
96MP0002752_abnormal_somatic_nervous0.94955330
97MP0002735_abnormal_chemical_nociception0.94784796
98MP0006036_abnormal_mitochondrial_physio0.94729157
99MP0003890_abnormal_embryonic-extraembry0.94528032
100MP0002254_reproductive_system_inflammat0.92806135
101MP0009763_increased_sensitivity_to0.92671396
102MP0002234_abnormal_pharynx_morphology0.92643083
103MP0009642_abnormal_blood_homeostasis0.92111737
104MP0005084_abnormal_gallbladder_morpholo0.92022912
105MP0005408_hypopigmentation0.90786307
106MP0002184_abnormal_innervation0.90599160
107MP0002160_abnormal_reproductive_system0.89474154
108MP0008469_abnormal_protein_level0.88633901
109MP0001529_abnormal_vocalization0.87579962
110MP0002229_neurodegeneration0.85827614
111MP0000955_abnormal_spinal_cord0.85291091
112MP0002938_white_spotting0.84973298
113MP0008789_abnormal_olfactory_epithelium0.83810833
114MP0002876_abnormal_thyroid_physiology0.83701633
115MP0005389_reproductive_system_phenotype0.83320581
116MP0000026_abnormal_inner_ear0.82952080
117MP0002136_abnormal_kidney_physiology0.82943735
118MP0001293_anophthalmia0.81195900
119MP0005376_homeostasis/metabolism_phenot0.80641103
120MP0002909_abnormal_adrenal_gland0.79605869
121MP0002078_abnormal_glucose_homeostasis0.79577767
122MP0001963_abnormal_hearing_physiology0.79440560
123MP0005670_abnormal_white_adipose0.74403785
124MP0009765_abnormal_xenobiotic_induced0.73351862
125MP0005535_abnormal_body_temperature0.72885657
126MP0005220_abnormal_exocrine_pancreas0.72675941
127MP0003329_amyloid_beta_deposits0.67243233
128MP0009053_abnormal_anal_canal0.66103969
129MP0001661_extended_life_span0.65548809
130MP0002971_abnormal_brown_adipose0.64932318
131MP0001765_abnormal_ion_homeostasis0.63401722
132MP0005334_abnormal_fat_pad0.60189623
133MP0005266_abnormal_metabolism0.59295566
134MP0003690_abnormal_glial_cell0.58335702
135MP0004130_abnormal_muscle_cell0.58055026
136MP0000639_abnormal_adrenal_gland0.56501114
137MP0006035_abnormal_mitochondrial_morpho0.54179378
138MP0005395_other_phenotype0.54066092
139MP0003638_abnormal_response/metabolism_0.53165663
140MP0005464_abnormal_platelet_physiology0.51051953
141MP0004264_abnormal_extraembryonic_tissu0.50998560
142MP0005058_abnormal_lysosome_morphology0.50611673
143MP0002928_abnormal_bile_duct0.48814726
144MP0005448_abnormal_energy_balance0.46353511
145MP0000230_abnormal_systemic_arterial0.44207125
146MP0003075_altered_response_to0.43838883
147MP0003718_maternal_effect0.43720916
148MP0003953_abnormal_hormone_level0.43648972
149MP0005666_abnormal_adipose_tissue0.42516354
150MP0009672_abnormal_birth_weight0.41867852
151MP0008872_abnormal_physiological_respon0.41023141
152MP0002168_other_aberrant_phenotype0.40812963
153MP0008873_increased_physiological_sensi0.40725587
154MP0008874_decreased_physiological_sensi0.40679578
155MP0002796_impaired_skin_barrier0.40036176
156MP0002135_abnormal_kidney_morphology0.37680201
157MP0002837_dystrophic_cardiac_calcinosis0.37521587
158MP0005166_decreased_susceptibility_to0.37069766
159MP0004883_abnormal_blood_vessel0.35525041
160MP0004782_abnormal_surfactant_physiolog0.35174768
161MP0004147_increased_porphyrin_level0.34884348
162MP0003724_increased_susceptibility_to0.34586157
163MP0002822_catalepsy0.33927991
164MP0000538_abnormal_urinary_bladder0.32667246
165MP0003436_decreased_susceptibility_to0.31114766
166MP0005167_abnormal_blood-brain_barrier0.30037464
167MP0000249_abnormal_blood_vessel0.29972511
168MP0001845_abnormal_inflammatory_respons0.29570776
169MP0009115_abnormal_fat_cell0.29295137
170MP0001243_abnormal_dermal_layer0.27590797
171MP0005164_abnormal_response_to0.26663772
172MP0006082_CNS_inflammation0.26120625
173MP0005248_abnormal_Harderian_gland0.24807494
174MP0002970_abnormal_white_adipose0.23750307

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.07834476
2Deep venous thrombosis (HP:0002625)6.98788938
3Intrahepatic cholestasis (HP:0001406)6.52956781
4Xanthomatosis (HP:0000991)6.13612600
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.06082298
6Prolonged partial thromboplastin time (HP:0003645)6.01560474
7Hypobetalipoproteinemia (HP:0003563)5.86996961
8Hyperlipoproteinemia (HP:0010980)5.03189994
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.71072801
10Joint hemorrhage (HP:0005261)4.67270442
11Hyperammonemia (HP:0001987)4.64689068
12Hypolipoproteinemia (HP:0010981)4.57366093
13Hyperglycinuria (HP:0003108)4.51415388
14Complement deficiency (HP:0004431)4.48765120
15Ketosis (HP:0001946)4.46103799
16Hyperglycinemia (HP:0002154)4.44199459
17Abnormality of serine family amino acid metabolism (HP:0010894)4.33297238
18Abnormality of glycine metabolism (HP:0010895)4.33297238
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.26044187
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.20216147
21Abnormality of the common coagulation pathway (HP:0010990)4.19353720
22Pancreatic fibrosis (HP:0100732)4.14723091
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13875940
24Pancreatic cysts (HP:0001737)4.13036672
25Hypoalphalipoproteinemia (HP:0003233)4.11136173
26Hypoglycemic coma (HP:0001325)3.99008710
27Abnormality of methionine metabolism (HP:0010901)3.92947529
28Epidermoid cyst (HP:0200040)3.92675361
29Fat malabsorption (HP:0002630)3.69160138
30Abnormality of fatty-acid metabolism (HP:0004359)3.64267497
31Molar tooth sign on MRI (HP:0002419)3.64167748
32Abnormality of midbrain morphology (HP:0002418)3.64167748
33Abnormality of pyrimidine metabolism (HP:0004353)3.59787916
34True hermaphroditism (HP:0010459)3.55039505
35Gout (HP:0001997)3.52948161
36Congenital stationary night blindness (HP:0007642)3.52743956
37Progressive cerebellar ataxia (HP:0002073)3.51858624
38Abnormality of the intrinsic pathway (HP:0010989)3.51514094
39Ketoacidosis (HP:0001993)3.38939142
40Medial flaring of the eyebrow (HP:0010747)3.34758759
41Abnormality of nucleobase metabolism (HP:0010932)3.32114265
42Hypercholesterolemia (HP:0003124)3.28038122
43Nephronophthisis (HP:0000090)3.25599410
44Abnormality of complement system (HP:0005339)3.23868091
45Hyperbilirubinemia (HP:0002904)3.21207719
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19601393
47Conjugated hyperbilirubinemia (HP:0002908)3.19313440
48Abnormality of purine metabolism (HP:0004352)3.18277440
49Delayed CNS myelination (HP:0002188)3.15252711
50Abnormality of serum amino acid levels (HP:0003112)3.08344903
51Hepatocellular carcinoma (HP:0001402)3.02970206
52Abnormality of the renal cortex (HP:0011035)3.01490135
53Metabolic acidosis (HP:0001942)2.95505435
54Chronic hepatic failure (HP:0100626)2.93980738
55Genetic anticipation (HP:0003743)2.91078048
56Hyperventilation (HP:0002883)2.90430370
57Abnormality of the renal medulla (HP:0100957)2.89762784
58Gait imbalance (HP:0002141)2.85854143
59Spontaneous abortion (HP:0005268)2.84144649
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83790585
61Dicarboxylic aciduria (HP:0003215)2.83790585
62Cystic liver disease (HP:0006706)2.75738762
63Abolished electroretinogram (ERG) (HP:0000550)2.73570652
64Lethargy (HP:0001254)2.73259874
65Generalized aminoaciduria (HP:0002909)2.71013394
66Vascular calcification (HP:0004934)2.70553918
67Steatorrhea (HP:0002570)2.70465740
68Hypochromic microcytic anemia (HP:0004840)2.69063543
69Proximal tubulopathy (HP:0000114)2.67853254
70Congenital primary aphakia (HP:0007707)2.67265534
71Alkalosis (HP:0001948)2.65229088
72Fair hair (HP:0002286)2.57963371
73Attenuation of retinal blood vessels (HP:0007843)2.57148942
74Febrile seizures (HP:0002373)2.56410428
75Type II lissencephaly (HP:0007260)2.53390156
76Abnormal biliary tract physiology (HP:0012439)2.50733051
77Bile duct proliferation (HP:0001408)2.50733051
78Myocardial infarction (HP:0001658)2.50173956
79Increased purine levels (HP:0004368)2.48703281
80Hyperuricemia (HP:0002149)2.48703281
81Hypoglycemic seizures (HP:0002173)2.47934032
82Cerebral edema (HP:0002181)2.47460468
83Nephrogenic diabetes insipidus (HP:0009806)2.46366212
84Enlarged kidneys (HP:0000105)2.45987960
85Malnutrition (HP:0004395)2.44903238
86Spastic diplegia (HP:0001264)2.44380231
87Irritability (HP:0000737)2.44172261
88Systemic lupus erythematosus (HP:0002725)2.44054387
89Acanthocytosis (HP:0001927)2.43831056
90Pendular nystagmus (HP:0012043)2.43628123
91Neonatal onset (HP:0003623)2.40659151
92Cardiovascular calcification (HP:0011915)2.39886074
93Skin nodule (HP:0200036)2.39113501
94Renal cortical cysts (HP:0000803)2.36203360
95Decreased central vision (HP:0007663)2.35874103
96Hydroxyprolinuria (HP:0003080)2.35142051
97Abnormality of proline metabolism (HP:0010907)2.35142051
98Vomiting (HP:0002013)2.34344933
99Protruding tongue (HP:0010808)2.33902991
100Amyloidosis (HP:0011034)2.32544770
101Sclerocornea (HP:0000647)2.29153014
102Abnormal rod and cone electroretinograms (HP:0008323)2.27927610
103Genital tract atresia (HP:0001827)2.26911633
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.26817785
105Glomerulonephritis (HP:0000099)2.26395617
106Congenital hepatic fibrosis (HP:0002612)2.26284694
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26172804
108Abnormality of alanine metabolism (HP:0010916)2.26172804
109Hyperalaninemia (HP:0003348)2.26172804
110Abnormal gallbladder morphology (HP:0012437)2.23598207
111Abnormal drinking behavior (HP:0030082)2.21968999
112Polydipsia (HP:0001959)2.21968999
113Pancreatitis (HP:0001733)2.21281746
114Rickets (HP:0002748)2.21174779
115Mitral stenosis (HP:0001718)2.20590553
116Abnormality of urine glucose concentration (HP:0011016)2.20480380
117Glycosuria (HP:0003076)2.20480380
118Cholelithiasis (HP:0001081)2.19967782
119Polyphagia (HP:0002591)2.19711029
120Tubular atrophy (HP:0000092)2.18946244
121Vaginal atresia (HP:0000148)2.18110462
122Confusion (HP:0001289)2.16818889
123Poor coordination (HP:0002370)2.15114369
124Cholecystitis (HP:0001082)2.13303556
125Abnormal gallbladder physiology (HP:0012438)2.13303556
126Broad-based gait (HP:0002136)2.11626832
127Lissencephaly (HP:0001339)2.10878577
128Esophageal varix (HP:0002040)2.09757490
129Sensorimotor neuropathy (HP:0007141)2.08614902
130Late onset (HP:0003584)2.08306097
131Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07855506
132Thrombophlebitis (HP:0004418)2.07310803
133Bony spicule pigmentary retinopathy (HP:0007737)2.07197061
134Menorrhagia (HP:0000132)2.06693079
135Anencephaly (HP:0002323)2.06634343
136Gaze-evoked nystagmus (HP:0000640)2.05394645
137Gingival bleeding (HP:0000225)2.04853512
138Focal seizures (HP:0007359)2.03840021
139Aplasia/Hypoplasia of the tongue (HP:0010295)2.02757266
140Pachygyria (HP:0001302)2.00609784
141Hyperinsulinemic hypoglycemia (HP:0000825)1.99448307
142Male pseudohermaphroditism (HP:0000037)1.99122435
143Hypophosphatemic rickets (HP:0004912)1.99067625
144Keratoconus (HP:0000563)1.97316682
145Increased corneal curvature (HP:0100692)1.97316682
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96284124
147Recurrent gram-negative bacterial infections (HP:0005420)1.96028470
148Brushfield spots (HP:0001088)1.95748449
149Abnormal enzyme/coenzyme activity (HP:0012379)1.95354620
150Postaxial foot polydactyly (HP:0001830)1.93508442
151Poikilocytosis (HP:0004447)1.92818970
152Chorioretinal atrophy (HP:0000533)1.92532135
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.91007714
154Absent/shortened dynein arms (HP:0200106)1.91007714
155Opisthotonus (HP:0002179)1.90356241
156Decreased circulating renin level (HP:0003351)1.90346113
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.90234586
158Abnormal respiratory epithelium morphology (HP:0012253)1.90209505
159Abnormal respiratory motile cilium morphology (HP:0005938)1.90209505
160Focal motor seizures (HP:0011153)1.89559852
161Nausea (HP:0002018)1.89444153
162Abnormality of vitamin metabolism (HP:0100508)1.89399993
163Hemorrhage of the eye (HP:0011885)1.89379746
164Abnormality of the labia minora (HP:0012880)1.89067197
165Abnormal cartilage morphology (HP:0002763)1.88984954
166Polyuria (HP:0000103)1.88833142
167Nephrolithiasis (HP:0000787)1.88593279
168Retinitis pigmentosa (HP:0000510)1.85790865
169Dyskinesia (HP:0100660)1.84686182
170Asplenia (HP:0001746)1.82351012
171Status epilepticus (HP:0002133)1.80984413
172Thyroid-stimulating hormone excess (HP:0002925)1.80763478
173Agitation (HP:0000713)1.80242159
174Generalized hypopigmentation of hair (HP:0011358)1.79420203
175Specific learning disability (HP:0001328)1.79268550
176Acute encephalopathy (HP:0006846)1.78411376
177Rib fusion (HP:0000902)1.78030897
178Congenital sensorineural hearing impairment (HP:0008527)1.77534498
179Inability to walk (HP:0002540)1.76787889
180Drooling (HP:0002307)1.76758760
181Dialeptic seizures (HP:0011146)1.75773077
182Acute necrotizing encephalopathy (HP:0006965)1.75026812
183Postaxial hand polydactyly (HP:0001162)1.74809917
184Epileptic encephalopathy (HP:0200134)1.71010309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.57877209
2FGFR44.28803333
3SIK13.93730391
4ERN13.93473235
5BMPR1B3.24614325
6INSRR2.76641664
7WNK32.56590263
8WNK42.46007047
9TAOK32.36986217
10ADRBK22.35345468
11ACVR1B2.25412585
12MST1R2.22105414
13PKN22.22094384
14ERBB42.20447780
15MAP4K22.19279726
16CASK2.14271514
17MAPK132.11413856
18MAP3K42.06449704
19OXSR12.02468615
20NUAK11.96952552
21MAP2K41.95896569
22TRIB31.83458235
23MAPK111.78055299
24FLT31.77308073
25DYRK21.62650039
26PIK3CG1.62229156
27NTRK31.62167366
28ZAK1.59937470
29PTK61.55619544
30MAP2K71.54456753
31TXK1.53605128
32MARK11.52136821
33TYK21.51572257
34DAPK21.49172246
35TNIK1.46163611
36STK38L1.44473246
37ABL21.43357210
38STK161.39964350
39LATS11.36267661
40KDR1.34957329
41GRK61.34766312
42PIK3CA1.34060602
43NTRK21.31509817
44CDK191.28183166
45NEK91.27968622
46PINK11.21945577
47CAMKK21.16744989
48MAP2K31.12686111
49TIE11.12271280
50ADRBK11.11644917
51JAK21.10638653
52MAP3K31.10261073
53PRKAA21.06869592
54FRK1.05791927
55MAP3K71.05559896
56SIK21.03751117
57TLK11.01611856
58MET0.96786774
59BCR0.96579662
60EPHB10.96255452
61FGFR20.95930369
62MAP3K110.94697231
63STK110.92708904
64CSNK1G20.86130531
65TGFBR20.85969833
66SGK2230.85094962
67SGK4940.85094962
68MAP3K100.84427717
69PRKCE0.84163291
70PRKCZ0.83712413
71TBK10.82427308
72PLK20.80843411
73MAPK40.80814489
74ERBB20.80687583
75PTK20.80487624
76GSK3A0.79171502
77DYRK1B0.77239097
78PRKACG0.76243468
79MAP3K140.75909230
80EPHB20.75281383
81JAK10.75137562
82NEK10.74979534
83SGK30.74822198
84MAPK120.74241309
85CSNK1A1L0.73117176
86AKT30.73004688
87MKNK20.71317262
88PRKAA10.69480243
89TGFBR10.68868724
90TEC0.67354688
91PRKACA0.66552165
92CAMK10.66098936
93MAPK150.66045047
94PDK40.65764390
95PDK30.65764390
96OBSCN0.64336089
97STK30.63286780
98CDK60.63211697
99STK390.62696367
100CSK0.62304870
101SGK20.61668331
102RIPK10.61556383
103PDPK10.60475834
104CSNK1G30.60341326
105MAP2K60.59398416
106TRIM280.58679208
107DYRK1A0.58282551
108PHKG20.58169286
109PHKG10.58169286
110TAF10.57451571
111TNK20.57329802
112MINK10.57174273
113GRK70.56771100
114DYRK30.55659595
115CAMK2G0.54768671
116PKN10.54386121
117CAMK2A0.52793981
118SGK10.50232405
119CSNK1A10.50137640
120EPHA30.49979314
121BRSK20.48097352
122TAOK20.48018768
123WNK10.47365635
124KIT0.46195785
125PRKG10.44248370
126PRKCQ0.43709343
127MAP2K10.43471883
128GRK10.43219532
129ERBB30.42962172
130MUSK0.42905146
131PBK0.41981380
132CSNK1D0.41147629
133CAMK1D0.40762554
134EPHA40.40012174
135GRK50.39858399
136PDK10.39845453
137CAMKK10.39792261
138CDK50.37762455
139PRKCG0.37031978
140IGF1R0.36822271
141MAPK70.35954026
142CSF1R0.35034759
143PAK30.34851715
144CSNK1G10.34610831
145RPS6KA50.33124614
146MAP3K50.33058777
147IRAK30.32804241
148RET0.32135421
149IKBKE0.31761766
150PDK20.31648551
151RPS6KA30.31301692
152STK380.29298022
153MTOR0.28564974
154FGFR30.28492930
155CDK40.28333958
156CAMK40.27635954
157PRKCA0.27294604
158MAP3K20.26983056
159MAP2K20.26380005
160EGFR0.26327325
161MAP3K60.26219425
162MAP3K130.26006064
163LRRK20.23883793
164MAP3K10.23672552

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13071213
2Nitrogen metabolism_Homo sapiens_hsa009103.47754985
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40832923
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30027029
5Arginine biosynthesis_Homo sapiens_hsa002202.95762869
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82020072
7Tryptophan metabolism_Homo sapiens_hsa003802.67985566
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65068391
9Complement and coagulation cascades_Homo sapiens_hsa046102.60802109
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59247117
11Fatty acid degradation_Homo sapiens_hsa000712.56604850
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54832375
13Butanoate metabolism_Homo sapiens_hsa006502.35866690
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29617561
15Propanoate metabolism_Homo sapiens_hsa006402.13370224
16Peroxisome_Homo sapiens_hsa041462.13128640
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07527985
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98227136
19Nicotine addiction_Homo sapiens_hsa050331.97226075
20Fatty acid metabolism_Homo sapiens_hsa012121.86608756
21Chemical carcinogenesis_Homo sapiens_hsa052041.86322538
22PPAR signaling pathway_Homo sapiens_hsa033201.85642546
23Histidine metabolism_Homo sapiens_hsa003401.84623420
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83928071
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.78738137
26beta-Alanine metabolism_Homo sapiens_hsa004101.76904892
27Phototransduction_Homo sapiens_hsa047441.76234201
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73978440
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69206841
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.59344212
31Staphylococcus aureus infection_Homo sapiens_hsa051501.59008061
32Retinol metabolism_Homo sapiens_hsa008301.55820921
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55358035
34Phenylalanine metabolism_Homo sapiens_hsa003601.54531292
35Selenocompound metabolism_Homo sapiens_hsa004501.53672345
36Caffeine metabolism_Homo sapiens_hsa002321.51385082
37Pyruvate metabolism_Homo sapiens_hsa006201.50346010
38Bile secretion_Homo sapiens_hsa049761.50147661
39Sulfur metabolism_Homo sapiens_hsa009201.44081807
40Fatty acid elongation_Homo sapiens_hsa000621.37762113
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36257995
42Tyrosine metabolism_Homo sapiens_hsa003501.33858042
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33028760
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28826495
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.27496417
46Carbon metabolism_Homo sapiens_hsa012001.25254496
47Starch and sucrose metabolism_Homo sapiens_hsa005001.24381566
48Biosynthesis of amino acids_Homo sapiens_hsa012301.24209485
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.24047369
50Folate biosynthesis_Homo sapiens_hsa007901.22461475
51Steroid biosynthesis_Homo sapiens_hsa001001.21016443
52Morphine addiction_Homo sapiens_hsa050321.19927545
53Fat digestion and absorption_Homo sapiens_hsa049751.17908605
54Vitamin digestion and absorption_Homo sapiens_hsa049771.15659000
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12581339
56GABAergic synapse_Homo sapiens_hsa047271.10808787
57Arginine and proline metabolism_Homo sapiens_hsa003301.08876870
58ABC transporters_Homo sapiens_hsa020101.07170605
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04527939
60Oxidative phosphorylation_Homo sapiens_hsa001901.03476845
61Taste transduction_Homo sapiens_hsa047421.01929289
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97770144
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.96732888
64Serotonergic synapse_Homo sapiens_hsa047260.95283120
65Sulfur relay system_Homo sapiens_hsa041220.94791851
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90954327
67Ether lipid metabolism_Homo sapiens_hsa005650.90009868
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89488048
69Lysine degradation_Homo sapiens_hsa003100.88560840
70Protein export_Homo sapiens_hsa030600.88441060
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88122071
72Glutamatergic synapse_Homo sapiens_hsa047240.86934824
73Vitamin B6 metabolism_Homo sapiens_hsa007500.86315619
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82924583
75Olfactory transduction_Homo sapiens_hsa047400.81835791
76Glutathione metabolism_Homo sapiens_hsa004800.79952919
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79789885
78Insulin secretion_Homo sapiens_hsa049110.79205955
79Circadian entrainment_Homo sapiens_hsa047130.76643098
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73710013
81Glycerolipid metabolism_Homo sapiens_hsa005610.71711222
82One carbon pool by folate_Homo sapiens_hsa006700.70980468
83Parkinsons disease_Homo sapiens_hsa050120.70437699
84Cardiac muscle contraction_Homo sapiens_hsa042600.69632762
85Pentose phosphate pathway_Homo sapiens_hsa000300.62250529
86Homologous recombination_Homo sapiens_hsa034400.57054493
87Metabolic pathways_Homo sapiens_hsa011000.48591671
88Fanconi anemia pathway_Homo sapiens_hsa034600.47134731
89Salivary secretion_Homo sapiens_hsa049700.45113229
90Fatty acid biosynthesis_Homo sapiens_hsa000610.40730056
91Alzheimers disease_Homo sapiens_hsa050100.39114639
92Huntingtons disease_Homo sapiens_hsa050160.38741162
93Basal transcription factors_Homo sapiens_hsa030220.36840964
94Dopaminergic synapse_Homo sapiens_hsa047280.36439107
95Cholinergic synapse_Homo sapiens_hsa047250.35395599
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35327735
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34662567
98Fructose and mannose metabolism_Homo sapiens_hsa000510.34331837
99Calcium signaling pathway_Homo sapiens_hsa040200.32843639
100Galactose metabolism_Homo sapiens_hsa000520.32024950
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.31667731
102Dorso-ventral axis formation_Homo sapiens_hsa043200.30782683
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.30444933
104Cocaine addiction_Homo sapiens_hsa050300.29650341
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28189651
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25914720
107RNA degradation_Homo sapiens_hsa030180.25875298
108Renin secretion_Homo sapiens_hsa049240.23588325
109Oxytocin signaling pathway_Homo sapiens_hsa049210.22025634
110Insulin resistance_Homo sapiens_hsa049310.20761067
111Linoleic acid metabolism_Homo sapiens_hsa005910.19794672
112Prion diseases_Homo sapiens_hsa050200.19642297
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.17763343
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.10943007
115Glucagon signaling pathway_Homo sapiens_hsa049220.07368758
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00549043
117AMPK signaling pathway_Homo sapiens_hsa041520.00360818
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2029363
119Lysosome_Homo sapiens_hsa04142-0.1930080
120Other glycan degradation_Homo sapiens_hsa00511-0.1861179
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1841221
122Regulation of autophagy_Homo sapiens_hsa04140-0.1776343
123Hepatitis C_Homo sapiens_hsa05160-0.1750040
124Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1649027
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1631153
126African trypanosomiasis_Homo sapiens_hsa05143-0.1630957
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1604686
128Insulin signaling pathway_Homo sapiens_hsa04910-0.1354430
129Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1323514
130Protein digestion and absorption_Homo sapiens_hsa04974-0.1312129
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1064277
132Mineral absorption_Homo sapiens_hsa04978-0.1052741
133Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1044716
134Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1017722
135Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0882933
136Renin-angiotensin system_Homo sapiens_hsa04614-0.0463992
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0260737

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