SPPL2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.43581075
2L-phenylalanine catabolic process (GO:0006559)4.43581075
3aromatic amino acid family catabolic process (GO:0009074)4.19201909
4L-phenylalanine metabolic process (GO:0006558)4.08159671
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.08159671
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05829634
7complement activation, alternative pathway (GO:0006957)3.98454163
8peptidyl-glutamic acid carboxylation (GO:0017187)3.93314679
9protein carboxylation (GO:0018214)3.93314679
10urea metabolic process (GO:0019627)3.93311481
11urea cycle (GO:0000050)3.93311481
12indole-containing compound catabolic process (GO:0042436)3.92412538
13indolalkylamine catabolic process (GO:0046218)3.92412538
14tryptophan catabolic process (GO:0006569)3.92412538
15tryptophan metabolic process (GO:0006568)3.77780873
16bile acid biosynthetic process (GO:0006699)3.70887908
17alpha-linolenic acid metabolic process (GO:0036109)3.69639399
18bile acid and bile salt transport (GO:0015721)3.66314294
19regulation of protein activation cascade (GO:2000257)3.64540154
20kynurenine metabolic process (GO:0070189)3.61667504
21nitrogen cycle metabolic process (GO:0071941)3.56493088
22sulfur amino acid catabolic process (GO:0000098)3.56224450
23regulation of complement activation (GO:0030449)3.47500818
24plasma lipoprotein particle clearance (GO:0034381)3.41819226
25phospholipid efflux (GO:0033700)3.41690697
26regulation of mononuclear cell migration (GO:0071675)3.41535743
27high-density lipoprotein particle remodeling (GO:0034375)3.39557526
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35886898
29glyoxylate metabolic process (GO:0046487)3.35877021
30homocysteine metabolic process (GO:0050667)3.35635253
31regulation of triglyceride catabolic process (GO:0010896)3.35577439
32negative regulation of fibrinolysis (GO:0051918)3.32585156
33regulation of vitamin metabolic process (GO:0030656)3.29272388
34regulation of fibrinolysis (GO:0051917)3.27704587
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24622646
36cysteine metabolic process (GO:0006534)3.24223352
37cellular glucuronidation (GO:0052695)3.23496824
38reverse cholesterol transport (GO:0043691)3.22707506
39bile acid metabolic process (GO:0008206)3.22601963
40negative regulation of interleukin-12 production (GO:0032695)3.20681449
41regulation of vitamin D biosynthetic process (GO:0060556)3.20580873
42oligosaccharide catabolic process (GO:0009313)3.19431516
43skeletal muscle adaptation (GO:0043501)3.18881410
44phospholipid homeostasis (GO:0055091)3.17983647
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17693391
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.17693391
47striated muscle atrophy (GO:0014891)3.13933006
48positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.12780189
49eosinophil chemotaxis (GO:0048245)3.11192770
50regulation of cholesterol esterification (GO:0010872)3.10290639
51acute-phase response (GO:0006953)3.09978742
52protein-lipid complex remodeling (GO:0034368)3.09739412
53macromolecular complex remodeling (GO:0034367)3.09739412
54plasma lipoprotein particle remodeling (GO:0034369)3.09739412
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08254661
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.08254661
57modulation by symbiont of host immune response (GO:0052553)3.08254661
58positive regulation by symbiont of host defense response (GO:0052509)3.08254661
59modulation by symbiont of host defense response (GO:0052031)3.08254661
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08254661
61antigen processing and presentation of endogenous antigen (GO:0019883)3.05939072
62cholesterol efflux (GO:0033344)3.05516857
63uronic acid metabolic process (GO:0006063)3.05393763
64glucuronate metabolic process (GO:0019585)3.05393763
65macroautophagy (GO:0016236)2.96269642
66fibrinolysis (GO:0042730)2.96023270
67tyrosine metabolic process (GO:0006570)2.93922335
68sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93578792
69cellular response to ethanol (GO:0071361)2.90471813
70acylglycerol homeostasis (GO:0055090)2.89296746
71triglyceride homeostasis (GO:0070328)2.89296746
72positive regulation of interferon-alpha production (GO:0032727)2.88782527
73aromatic amino acid family metabolic process (GO:0009072)2.87996684
74positive regulation of lipid catabolic process (GO:0050996)2.85738611
75lysine catabolic process (GO:0006554)2.81749999
76lysine metabolic process (GO:0006553)2.81749999
77aldehyde catabolic process (GO:0046185)2.81477179
78plasma lipoprotein particle assembly (GO:0034377)2.80278998
79low-density lipoprotein particle remodeling (GO:0034374)2.78567672
80amino-acid betaine metabolic process (GO:0006577)2.77500515
81complement activation (GO:0006956)2.76734790
82negative regulation of cholesterol transport (GO:0032375)2.76517119
83negative regulation of sterol transport (GO:0032372)2.76517119
84indolalkylamine metabolic process (GO:0006586)2.75852383
85neutrophil activation involved in immune response (GO:0002283)2.74930376
86regulation of interferon-alpha production (GO:0032647)2.73671500
87eosinophil migration (GO:0072677)2.72274680
88regulation of cholesterol storage (GO:0010885)2.71002935
89protein activation cascade (GO:0072376)2.70606318
90complement activation, classical pathway (GO:0006958)2.69846940
91low-density lipoprotein particle clearance (GO:0034383)2.69628745
92amine catabolic process (GO:0009310)2.68153923
93cellular biogenic amine catabolic process (GO:0042402)2.68153923
94epoxygenase P450 pathway (GO:0019373)2.66534008
95cholesterol homeostasis (GO:0042632)2.66020076
96lipoprotein metabolic process (GO:0042157)2.65703266
97T-helper 1 type immune response (GO:0042088)2.65475605
98sterol homeostasis (GO:0055092)2.65136545
99negative regulation of leukocyte chemotaxis (GO:0002689)2.63962617
100protein-lipid complex assembly (GO:0065005)2.63867979
101positive regulation of cellular amide metabolic process (GO:0034250)2.63818880
102glycosphingolipid catabolic process (GO:0046479)2.63478433
103benzene-containing compound metabolic process (GO:0042537)2.62973715
104regulation of skeletal muscle contraction (GO:0014819)2.62577287
105flavonoid metabolic process (GO:0009812)2.61569926
106opsonization (GO:0008228)2.60727516
107arginine metabolic process (GO:0006525)2.59560858
108plasma lipoprotein particle organization (GO:0071827)2.58857445
109regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57995655
110positive regulation of hemostasis (GO:1900048)2.57603611
111positive regulation of blood coagulation (GO:0030194)2.57603611
112ethanol oxidation (GO:0006069)2.57510017
113regulation of interferon-beta biosynthetic process (GO:0045357)2.56910280
114muscle filament sliding (GO:0030049)2.56494307
115actin-myosin filament sliding (GO:0033275)2.56494307
116negative regulation of lipid storage (GO:0010888)2.56071729
117skeletal muscle contraction (GO:0003009)2.55197290
118drug transmembrane transport (GO:0006855)2.54442164
119glycolipid catabolic process (GO:0019377)2.54154619
120alpha-amino acid catabolic process (GO:1901606)2.53739150
121NAD biosynthetic process (GO:0009435)2.53379305
122alkaloid metabolic process (GO:0009820)2.52922723
123positive regulation of coagulation (GO:0050820)2.52514115
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.51495779
125negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48877963
126regulation of chronic inflammatory response (GO:0002676)2.47591885
127positive regulation of fatty acid oxidation (GO:0046321)2.46510406
128regulation of macrophage chemotaxis (GO:0010758)2.44656970
129positive regulation of heat generation (GO:0031652)2.44636173
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44200732
131diol metabolic process (GO:0034311)2.43616644
132sphingosine metabolic process (GO:0006670)2.42722886
133ceramide catabolic process (GO:0046514)2.42601840
134muscle atrophy (GO:0014889)2.42600973
135exogenous drug catabolic process (GO:0042738)2.41408877
136sphingoid metabolic process (GO:0046519)2.40575939
137angiotensin maturation (GO:0002003)2.39878347
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39411783
139fat-soluble vitamin biosynthetic process (GO:0042362)2.39280990
140drug catabolic process (GO:0042737)2.38480289
141pyrimidine-containing compound transmembrane transport (GO:0072531)2.38222569
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.36170375
143hydrogen peroxide biosynthetic process (GO:0050665)2.31681169
144positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.30048556
145actin-mediated cell contraction (GO:0070252)2.29549123
146production of molecular mediator involved in inflammatory response (GO:0002532)2.29064372
147positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28381331
148nitric oxide biosynthetic process (GO:0006809)2.28317216
149positive regulation of chemokine biosynthetic process (GO:0045080)2.28252551
150response to type I interferon (GO:0034340)2.27662785
151negative regulation of systemic arterial blood pressure (GO:0003085)2.27123878
152regulation of cytokine secretion involved in immune response (GO:0002739)2.27016883
153virion attachment to host cell (GO:0019062)2.26358483
154adhesion of symbiont to host cell (GO:0044650)2.26358483
155regulation of lymphocyte chemotaxis (GO:1901623)2.25711368
156cellular response to exogenous dsRNA (GO:0071360)2.24710917
157fatty acid transmembrane transport (GO:1902001)2.23842019
158intestinal epithelial cell development (GO:0060576)2.22633252
159interferon-gamma-mediated signaling pathway (GO:0060333)2.22388141
160regulation of sequestering of triglyceride (GO:0010889)2.20444984
161type I interferon signaling pathway (GO:0060337)2.19370222
162cellular response to type I interferon (GO:0071357)2.19370222
163UDP-N-acetylglucosamine metabolic process (GO:0006047)2.19214239
164detection of molecule of bacterial origin (GO:0032490)2.18698918
165regulation of T cell tolerance induction (GO:0002664)2.18682121
166regulation of cellular extravasation (GO:0002691)2.18011881
167transcytosis (GO:0045056)2.16465834
168response to muscle activity (GO:0014850)2.16198902
169membrane lipid catabolic process (GO:0046466)2.14924201
170iron ion import (GO:0097286)2.13181506
171omega-hydroxylase P450 pathway (GO:0097267)2.13049461
172regulation of fever generation (GO:0031620)2.12168092
173intestinal absorption (GO:0050892)2.11770483
174regulation of macrophage derived foam cell differentiation (GO:0010743)2.11001530
175protein targeting to vacuole (GO:0006623)2.10775921
176protein targeting to lysosome (GO:0006622)2.10775921
177establishment of protein localization to vacuole (GO:0072666)2.10775921
178positive regulation of antigen processing and presentation (GO:0002579)2.08811258
179regulation of dendritic cell antigen processing and presentation (GO:0002604)2.08579886
180regulation of lipid storage (GO:0010883)2.07966745
181germinal center formation (GO:0002467)2.04773597
182regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.04181147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.41305787
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.65926276
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.36367267
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.17841676
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06482903
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.97867182
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32683815
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.27274677
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.89703590
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.72793751
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72688935
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72076985
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.65436497
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.64722833
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55166031
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.50227944
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44738044
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38895096
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25532395
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19587986
21GATA1_22025678_ChIP-Seq_K562_Human2.17837581
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17321878
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12008963
24* ESR1_20079471_ChIP-ChIP_T-47D_Human2.02205971
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91101609
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84328917
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81755971
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80024913
29* ER_23166858_ChIP-Seq_MCF-7_Human1.75921538
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70046683
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69808275
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.65990947
33CLOCK_20551151_ChIP-Seq_293T_Human1.58735171
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56159395
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46504878
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45151495
37AHR_22903824_ChIP-Seq_MCF-7_Human1.43325671
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40449343
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40449343
40VDR_24787735_ChIP-Seq_THP-1_Human1.40246465
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38857456
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35783125
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35758343
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34507246
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.34332375
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31923043
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31849324
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.31551449
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30734522
50* SOX2_20726797_ChIP-Seq_SW620_Human1.30434976
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29940111
52RUNX_20019798_ChIP-Seq_JUKART_Human1.28883355
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26820923
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26639781
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.26551758
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25139561
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24950217
58CDX2_22108803_ChIP-Seq_LS180_Human1.23355878
59VDR_22108803_ChIP-Seq_LS180_Human1.22085094
60* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21625802
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21353710
62TP53_16413492_ChIP-PET_HCT116_Human1.20661168
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20016324
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.19820448
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19443946
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17769080
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17167251
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15978751
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15871870
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15717332
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15614292
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15393189
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15057375
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14845581
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14834143
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14801656
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.14333511
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.14195400
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.14172777
80GATA4_25053715_ChIP-Seq_YYC3_Human1.12572045
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12494506
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.10298468
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.08905557
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08516166
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.07069181
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06835632
87CJUN_26792858_Chip-Seq_BT549_Human1.06622439
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05955486
89EGR1_19032775_ChIP-ChIP_M12_Human1.04785716
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02451488
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01682892
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.01439852
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01422617
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01206452
95PU_27001747_Chip-Seq_BMDM_Mouse1.01136278
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01122278
97GBX2_23144817_ChIP-Seq_PC3_Human1.00718110
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97276513
99BCAT_22108803_ChIP-Seq_LS180_Human0.96861413
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96830577
101* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95644660
102SCL_19346495_ChIP-Seq_HPC-7_Human0.94665600
103OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93873128
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92717281
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91869653
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90477722
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90310370
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90272059
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90098661
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89628995
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.89225269
112* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88439631
113ZNF274_21170338_ChIP-Seq_K562_Hela0.88095144
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.87766184
115GATA2_19941826_ChIP-Seq_K562_Human0.86959437
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.86457044
117P53_22387025_ChIP-Seq_ESCs_Mouse0.86127343
118GATA3_24758297_ChIP-Seq_MCF-7_Human0.85616011
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.85426124
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84093989
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82965825
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82615256
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82330830
124* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80351776
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79610866
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79610866
127RXR_22108803_ChIP-Seq_LS180_Human0.77683945
128* FOXA1_25552417_ChIP-Seq_VCAP_Human0.77421155
129* TP63_23658742_ChIP-Seq_EP156T_Human0.76965128
130GATA1_19941826_ChIP-Seq_K562_Human0.75687902
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75015424
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74198799
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72213735
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70546342
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69694602
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69450345
137* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69406618
138GATA3_26560356_Chip-Seq_TH2_Human0.68855586
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67932121
140HTT_18923047_ChIP-ChIP_STHdh_Human0.66443312
141TP53_18474530_ChIP-ChIP_U2OS_Human0.66434345
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66395976
143GATA6_25053715_ChIP-Seq_YYC3_Human0.65974560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.86195918
2MP0002139_abnormal_hepatobiliary_system4.84442689
3MP0005085_abnormal_gallbladder_physiolo3.87365663
4MP0005365_abnormal_bile_salt3.58791733
5MP0003646_muscle_fatigue3.40978859
6MP0008875_abnormal_xenobiotic_pharmacok3.00681584
7MP0003252_abnormal_bile_duct2.89158176
8MP0001835_abnormal_antigen_presentation2.61249788
9MP0002138_abnormal_hepatobiliary_system2.46344641
10MP0002837_dystrophic_cardiac_calcinosis2.37105081
11MP0003191_abnormal_cellular_cholesterol2.36221832
12MP0000569_abnormal_digit_pigmentation2.28308881
13MP0009840_abnormal_foam_cell2.27888462
14MP0010329_abnormal_lipoprotein_level2.26485353
15MP0003724_increased_susceptibility_to2.22836284
16MP0003436_decreased_susceptibility_to2.19401061
17MP0010234_abnormal_vibrissa_follicle2.16953091
18MP0003806_abnormal_nucleotide_metabolis2.13800390
19MP0003195_calcinosis2.08380565
20MP0009785_altered_susceptibility_to2.08150986
21MP0002254_reproductive_system_inflammat2.02361983
22MP0001666_abnormal_nutrient_absorption2.01939064
23MP0005083_abnormal_biliary_tract1.95211053
24MP0003950_abnormal_plasma_membrane1.93551518
25MP0006082_CNS_inflammation1.90085135
26MP0005058_abnormal_lysosome_morphology1.83049216
27MP0004145_abnormal_muscle_electrophysio1.82831517
28MP0002332_abnormal_exercise_endurance1.78457100
29MP0002419_abnormal_innate_immunity1.76237458
30MP0001790_abnormal_immune_system1.70408759
31MP0005387_immune_system_phenotype1.70408759
32MP0002148_abnormal_hypersensitivity_rea1.69345081
33MP0005332_abnormal_amino_acid1.68896060
34MP0009764_decreased_sensitivity_to1.68051225
35MP0004019_abnormal_vitamin_homeostasis1.66090015
36MP0005025_abnormal_response_to1.62816995
37MP0000609_abnormal_liver_physiology1.62328176
38MP0000749_muscle_degeneration1.61005304
39MP0003300_gastrointestinal_ulcer1.60850218
40MP0000685_abnormal_immune_system1.58261335
41MP0003303_peritoneal_inflammation1.53472109
42MP0005000_abnormal_immune_tolerance1.52256061
43MP0004043_abnormal_pH_regulation1.51456245
44MP0004947_skin_inflammation1.49174577
45MP0008469_abnormal_protein_level1.49154419
46MP0003183_abnormal_peptide_metabolism1.47926397
47MP0002118_abnormal_lipid_homeostasis1.41079302
48MP0005319_abnormal_enzyme/_coenzyme1.38701253
49MP0001533_abnormal_skeleton_physiology1.38330909
50MP0001800_abnormal_humoral_immune1.34972177
51MP0005464_abnormal_platelet_physiology1.33471951
52MP0004036_abnormal_muscle_relaxation1.33124929
53MP0005671_abnormal_response_to1.30199611
54MP0002452_abnormal_antigen_presenting1.30195903
55MP0003705_abnormal_hypodermis_morpholog1.28992296
56MP0000604_amyloidosis1.26488659
57MP0001845_abnormal_inflammatory_respons1.26096210
58MP0002166_altered_tumor_susceptibility1.25270196
59MP0005584_abnormal_enzyme/coenzyme_acti1.24756239
60MP0010155_abnormal_intestine_physiology1.24456997
61MP0002723_abnormal_immune_serum1.24155991
62MP0006054_spinal_hemorrhage1.23968914
63MP0009643_abnormal_urine_homeostasis1.22695841
64MP0001853_heart_inflammation1.19328261
65MP0004084_abnormal_cardiac_muscle1.16798595
66MP0003186_abnormal_redox_activity1.16669446
67MP0003075_altered_response_to1.16343715
68MP0009763_increased_sensitivity_to1.14562069
69MP0003690_abnormal_glial_cell1.13362543
70MP0000383_abnormal_hair_follicle1.12994833
71MP0003453_abnormal_keratinocyte_physiol1.10397139
72MP0004215_abnormal_myocardial_fiber1.09611010
73MP0003868_abnormal_feces_composition1.08047044
74MP0003656_abnormal_erythrocyte_physiolo1.08002831
75MP0005310_abnormal_salivary_gland1.06311647
76MP0005620_abnormal_muscle_contractility1.06131531
77MP0004510_myositis1.05563793
78MP0008438_abnormal_cutaneous_collagen1.03568660
79MP0004484_altered_response_of1.03105694
80MP0002006_tumorigenesis1.00410196
81MP0004782_abnormal_surfactant_physiolog0.99344616
82MP0001819_abnormal_immune_cell0.98846769
83MP0005451_abnormal_body_composition0.97093979
84MP0005166_decreased_susceptibility_to0.96902249
85MP0002420_abnormal_adaptive_immunity0.96512805
86MP0004883_abnormal_blood_vessel0.96354476
87MP0002998_abnormal_bone_remodeling0.95092658
88MP0000427_abnormal_hair_cycle0.94586462
89MP0003828_pulmonary_edema0.94326346
90MP0001542_abnormal_bone_strength0.93545220
91MP0005330_cardiomyopathy0.93438777
92MP0000598_abnormal_liver_morphology0.92673938
93MP0005164_abnormal_response_to0.91117734
94MP0000747_muscle_weakness0.90307542
95MP0010352_gastrointestinal_tract_polyps0.89522563
96MP0002876_abnormal_thyroid_physiology0.89292171
97MP0002277_abnormal_respiratory_mucosa0.88878957
98MP0002009_preneoplasia0.88188098
99MP0000343_altered_response_to0.88108663
100MP0002106_abnormal_muscle_physiology0.87750947
101MP0000750_abnormal_muscle_regeneration0.87176616
102MP0001764_abnormal_homeostasis0.86699906
103MP0004233_abnormal_muscle_weight0.86509934
104MP0002168_other_aberrant_phenotype0.86379859
105MP0005167_abnormal_blood-brain_barrier0.86188714
106MP0002972_abnormal_cardiac_muscle0.85700141
107MP0002136_abnormal_kidney_physiology0.85090708
108MP0005595_abnormal_vascular_smooth0.84904012
109MP0004264_abnormal_extraembryonic_tissu0.84342759
110MP0001663_abnormal_digestive_system0.84062665
111MP0001881_abnormal_mammary_gland0.83964411
112MP0005266_abnormal_metabolism0.82944869
113MP0000230_abnormal_systemic_arterial0.82046141
114MP0000538_abnormal_urinary_bladder0.81037993
115MP0005408_hypopigmentation0.81036247
116MP0003566_abnormal_cell_adhesion0.80105680
117MP0001958_emphysema0.79304482
118MP0004130_abnormal_muscle_cell0.79292412
119MP0000371_diluted_coat_color0.78083229
120MP0005636_abnormal_mineral_homeostasis0.77889679
121MP0002405_respiratory_system_inflammati0.77800216
122MP0002796_impaired_skin_barrier0.76906109
123MP0003172_abnormal_lysosome_physiology0.76274253
124MP0010678_abnormal_skin_adnexa0.75553792
125MP0005275_abnormal_skin_tensile0.75471043
126MP0001873_stomach_inflammation0.75443544
127MP0000249_abnormal_blood_vessel0.74347343
128MP0002933_joint_inflammation0.73877866
129MP0003045_fibrosis0.73674320
130MP0009765_abnormal_xenobiotic_induced0.71610701
131MP0010368_abnormal_lymphatic_system0.71272250
132MP0009642_abnormal_blood_homeostasis0.70431140
133MP0003448_altered_tumor_morphology0.69923562
134MP0009697_abnormal_copulation0.69559443
135MP0005084_abnormal_gallbladder_morpholo0.66486996
136MP0001756_abnormal_urination0.65776060
137MP0001216_abnormal_epidermal_layer0.64034952
138MP0002971_abnormal_brown_adipose0.64034056
139MP0002060_abnormal_skin_morphology0.63970171

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.07594046
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.07594046
3Abnormality of glycolipid metabolism (HP:0010969)5.07594046
4Intrahepatic cholestasis (HP:0001406)4.79528692
5Complement deficiency (HP:0004431)4.76464855
6Deep venous thrombosis (HP:0002625)4.67996058
7Muscle fiber inclusion bodies (HP:0100299)4.57895157
8Xanthomatosis (HP:0000991)4.54516872
9Nemaline bodies (HP:0003798)4.51990256
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.48950333
11Recurrent gram-negative bacterial infections (HP:0005420)4.43670023
12Prolonged partial thromboplastin time (HP:0003645)4.42401652
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.42263643
14Systemic lupus erythematosus (HP:0002725)4.40555299
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.25971145
16Joint hemorrhage (HP:0005261)3.96314526
17Eczematoid dermatitis (HP:0000976)3.95697277
18Hyperlipoproteinemia (HP:0010980)3.77918387
19Abnormality of complement system (HP:0005339)3.66460645
20Myocardial infarction (HP:0001658)3.66153658
21Abnormality of the common coagulation pathway (HP:0010990)3.58510448
22Hypobetalipoproteinemia (HP:0003563)3.58445607
23Type 1 muscle fiber predominance (HP:0003803)3.54955873
24Glomerulonephritis (HP:0000099)3.48391178
25Recurrent bacterial skin infections (HP:0005406)3.42911745
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.41189922
27Epidermoid cyst (HP:0200040)3.25813094
28Calf muscle hypertrophy (HP:0008981)3.25373544
29Muscle hypertrophy of the lower extremities (HP:0008968)3.24950740
30Fat malabsorption (HP:0002630)3.16867198
31Recurrent abscess formation (HP:0002722)3.15414821
32Asymmetric septal hypertrophy (HP:0001670)3.07671532
33Vacuolated lymphocytes (HP:0001922)3.01432713
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.98558709
35Hypolipoproteinemia (HP:0010981)2.97181496
36Conjugated hyperbilirubinemia (HP:0002908)2.94072629
37Esophageal varix (HP:0002040)2.88875531
38Gingival bleeding (HP:0000225)2.88158137
39Decreased circulating renin level (HP:0003351)2.88000224
40Hypoalphalipoproteinemia (HP:0003233)2.86272907
41Hypercholesterolemia (HP:0003124)2.80825817
42Retrobulbar optic neuritis (HP:0100654)2.79583674
43Optic neuritis (HP:0100653)2.79583674
44Hyperammonemia (HP:0001987)2.77142682
45Abnormality of macrophages (HP:0004311)2.73432750
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.71210635
47Abnormality of polysaccharide metabolism (HP:0011012)2.68992984
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68992984
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68992984
50Exercise-induced myalgia (HP:0003738)2.68306579
51Nephritis (HP:0000123)2.66843461
52Axonal loss (HP:0003447)2.65585490
53Autoimmune thrombocytopenia (HP:0001973)2.64636416
54Abnormality of the intrinsic pathway (HP:0010989)2.60088932
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56451442
56Steatorrhea (HP:0002570)2.50638869
57Abnormality of the calf musculature (HP:0001430)2.48347256
58Hypoglycemic coma (HP:0001325)2.47923409
59Amyloidosis (HP:0011034)2.47158142
60Malnutrition (HP:0004395)2.44115000
61Frequent falls (HP:0002359)2.41296699
62Abnormality of methionine metabolism (HP:0010901)2.41107836
63Recurrent skin infections (HP:0001581)2.38247066
64Thick nail (HP:0001805)2.37864644
65Mitral stenosis (HP:0001718)2.33113015
66Hepatocellular carcinoma (HP:0001402)2.32978304
67Hyporeflexia of lower limbs (HP:0002600)2.32597844
68Ketosis (HP:0001946)2.30046355
69Stomatitis (HP:0010280)2.28771653
70Vascular calcification (HP:0004934)2.28235713
71Abnormality of proline metabolism (HP:0010907)2.26396936
72Hydroxyprolinuria (HP:0003080)2.26396936
73EMG: myopathic abnormalities (HP:0003458)2.24342260
74Abnormality of purine metabolism (HP:0004352)2.22693861
75Ulnar deviation of the wrist (HP:0003049)2.21942020
76Chronic diarrhea (HP:0002028)2.21750853
77Pustule (HP:0200039)2.21662279
78Exercise-induced muscle cramps (HP:0003710)2.21514196
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20424222
80Spontaneous hematomas (HP:0007420)2.18705733
81Hyperkalemia (HP:0002153)2.17645617
82Abnormality of nucleobase metabolism (HP:0010932)2.17388934
83Abnormality of fatty-acid metabolism (HP:0004359)2.14991920
84Gastrointestinal infarctions (HP:0005244)2.13798069
85Cardiovascular calcification (HP:0011915)2.13419166
86Bundle branch block (HP:0011710)2.13314666
87Ovoid vertebral bodies (HP:0003300)2.13072965
88Hemorrhage of the eye (HP:0011885)2.12111483
89Thrombophlebitis (HP:0004418)2.12087237
90Disinhibition (HP:0000734)2.11922340
91Abnormality of iron homeostasis (HP:0011031)2.11331679
92Gingivitis (HP:0000230)2.09597896
93Fair hair (HP:0002286)2.08842257
94Abnormality of T cell number (HP:0011839)2.08411363
95Abnormality of pyrimidine metabolism (HP:0004353)2.06779079
96Pulmonary embolism (HP:0002204)2.05687903
97Bone cyst (HP:0012062)2.04535808
98Spontaneous abortion (HP:0005268)2.04306499
99Distal arthrogryposis (HP:0005684)2.04095823
100Periodontitis (HP:0000704)2.02909306
101Neck muscle weakness (HP:0000467)2.02424034
102Abnormality of transition element cation homeostasis (HP:0011030)2.02404879
103Hemoptysis (HP:0002105)2.01532308
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01329536
105Nausea (HP:0002018)2.00924768
106Rhabdomyolysis (HP:0003201)2.00800326
107Pulmonary infiltrates (HP:0002113)1.99493339
108Dysostosis multiplex (HP:0000943)1.99474378
109Hyperbilirubinemia (HP:0002904)1.99259437
110Myositis (HP:0100614)1.99117804
111Hyperglycinemia (HP:0002154)1.99025723
112Hyperglycinuria (HP:0003108)1.98228944
113Cone-rod dystrophy (HP:0000548)1.96743095
114Skin nodule (HP:0200036)1.96278604
115Mediastinal lymphadenopathy (HP:0100721)1.95622910
116Hematochezia (HP:0002573)1.94777719
117Muscle fiber splitting (HP:0003555)1.94693783
118Vasculitis (HP:0002633)1.94373770
119Abnormality of serine family amino acid metabolism (HP:0010894)1.94100418
120Abnormality of glycine metabolism (HP:0010895)1.94100418
121Urticaria (HP:0001025)1.93724811
122Hypokalemia (HP:0002900)1.93530496
123Menorrhagia (HP:0000132)1.93418371
124Myoglobinuria (HP:0002913)1.92379448
125Pancreatitis (HP:0001733)1.92364739
126Peritonitis (HP:0002586)1.91204691
127T lymphocytopenia (HP:0005403)1.90870247
128Hyperactive renin-angiotensin system (HP:0000841)1.90552660
129Increased serum ferritin (HP:0003281)1.90220960
130Loss of speech (HP:0002371)1.88888701
131Tetraparesis (HP:0002273)1.88376684
132Abnormality of potassium homeostasis (HP:0011042)1.87917799
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.87751196
134Osteolytic defects of the hand bones (HP:0009699)1.87751196
135Urinary glycosaminoglycan excretion (HP:0003541)1.87347182
136Mucopolysacchariduria (HP:0008155)1.87347182
137Increased cerebral lipofuscin (HP:0011813)1.87163905
138Abnormal cartilage morphology (HP:0002763)1.86786248
139Elevated erythrocyte sedimentation rate (HP:0003565)1.86179809
140Myopathic facies (HP:0002058)1.85473236
141Recurrent fungal infections (HP:0002841)1.84316981
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83994472
143Epistaxis (HP:0000421)1.83332495
144Generalized hypopigmentation of hair (HP:0011358)1.83059683
145Metabolic alkalosis (HP:0200114)1.82638649
146Anorexia (HP:0002039)1.82030099
147Interstitial pulmonary disease (HP:0006530)1.81649501
148Orchitis (HP:0100796)1.81366926
149J-shaped sella turcica (HP:0002680)1.80967319
150Congenital sensorineural hearing impairment (HP:0008527)1.79965309
151Clumsiness (HP:0002312)1.78588425
152Abnormality of the pericardium (HP:0001697)1.78430441
153Joint swelling (HP:0001386)1.78211499
154Syncope (HP:0001279)1.78072858
155Acanthocytosis (HP:0001927)1.75532140
156Facial diplegia (HP:0001349)1.75523241
157Metaphyseal irregularity (HP:0003025)1.75498499
158Protuberant abdomen (HP:0001538)1.75406580
159Increased neuronal autofluorescent lipopigment (HP:0002074)1.74900659
160Keratoconjunctivitis sicca (HP:0001097)1.72323989
161Abnormality of alanine metabolism (HP:0010916)1.71254366
162Hyperalaninemia (HP:0003348)1.71254366
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71254366
164Congenital, generalized hypertrichosis (HP:0004540)1.70412520
165Abnormality of renin-angiotensin system (HP:0000847)1.68482142
166Rimmed vacuoles (HP:0003805)1.67996884
167Large for gestational age (HP:0001520)1.67915386
168Generalized aminoaciduria (HP:0002909)1.67043679
169Keratoconjunctivitis (HP:0001096)1.65209718
170Abnormality of the renal cortex (HP:0011035)1.64666234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.56609631
2OBSCN4.31518673
3ACVR1B4.07584745
4MAP3K143.82458419
5TYK22.82564875
6ADRBK22.82448527
7FGFR42.73287320
8TBK12.49264732
9ERN12.24515938
10JAK12.15093278
11IKBKE2.10407717
12EPHB12.05097318
13SIK11.97432414
14FRK1.96625359
15IRAK31.93652525
16CAMKK21.92684741
17MST1R1.92508150
18MAPKAPK31.88813487
19CSF1R1.87668858
20IRAK41.83963257
21TGFBR21.83470210
22EPHA31.82896487
23JAK31.81107113
24RIPK41.74050211
25PBK1.61370218
26RIPK11.59780405
27IKBKB1.55610314
28DDR21.50111389
29MUSK1.46486979
30PIK3CA1.46163007
31NEK91.44279388
32EPHB21.43463506
33PINK11.43327601
34KIT1.42770340
35BLK1.40685725
36MAP3K131.40204789
37CSK1.36599893
38PIK3CG1.34280925
39FGFR31.32379206
40GRK11.32205670
41STK31.31762562
42INSRR1.31197471
43PTK61.27840009
44LATS11.24033450
45STK38L1.22353747
46PHKG21.21847365
47PHKG11.21847365
48MYLK1.21828788
49JAK21.19513925
50BCKDK1.18728387
51TXK1.16904563
52TLK11.13325107
53CHUK1.10000409
54MAP3K121.08706705
55MAP4K11.07362289
56NUAK11.06796113
57ERBB41.03641586
58BMPR1B1.03446286
59STK390.99576470
60MAP3K30.99220418
61OXSR10.98733091
62STK100.98103724
63IRAK10.90087816
64CAMK1D0.89585863
65MAP2K60.88974175
66MAPK150.88972208
67TIE10.88866742
68TRPM70.87639503
69NLK0.86021734
70TGFBR10.84609090
71FER0.82441776
72ITK0.80755097
73HCK0.79484776
74MAPK110.78014497
75ABL20.77586974
76ADRBK10.77259124
77CDK60.76724849
78ZAP700.76164017
79PRKCQ0.75785444
80GRK70.73428662
81MELK0.72697402
82CDC42BPA0.72517357
83PRKG20.72270378
84BTK0.70911091
85KDR0.70115622
86LCK0.70077310
87TTN0.70013591
88PRKAA20.67604246
89FLT30.66721555
90LYN0.66712461
91MST40.65574193
92PIM20.65181985
93TEC0.64346321
94MAP3K20.62963618
95GSK3A0.60728330
96MET0.58994103
97RPS6KA60.58593002
98EGFR0.57903385
99MAP2K30.57899918
100TRIB30.57737778
101SYK0.57632886
102BMPR20.57114222
103MAP2K20.56836196
104BMX0.56182147
105ABL10.55958228
106MOS0.55726599
107IGF1R0.54965595
108LIMK10.54856607
109WNK40.54624165
110PKN10.54454185
111MARK30.51761613
112MAP3K70.50886274
113MAPK70.49928442
114MAP2K10.49785122
115CAMK2D0.49282544
116EIF2AK20.48261310
117CAMK1G0.48177202
118ERBB30.46159003
119PDPK10.44764173
120STK40.44526944
121STK240.44237685
122NME20.43907622
123MAP3K10.42920611
124DYRK1B0.42645447
125MATK0.42005643
126PIM10.41442716
127LRRK20.41397191
128PDGFRB0.40830393
129MAPK40.40828135
130FGR0.40551828
131MAPK120.39907745
132PDK20.39627458
133ERBB20.38067301
134YES10.38039254
135RPS6KA20.37624138
136FGFR20.37255617
137PRKCD0.37191931
138PTK20.37173637
139GRK60.36372087
140PRKCE0.35567845
141DMPK0.34098956
142AKT30.32183198
143MAPKAPK20.31739898

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.59340466
2Staphylococcus aureus infection_Homo sapiens_hsa051503.10492722
3Complement and coagulation cascades_Homo sapiens_hsa046102.80970781
4Nitrogen metabolism_Homo sapiens_hsa009102.80498920
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68632883
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.52970487
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51487340
8Arginine biosynthesis_Homo sapiens_hsa002202.42390027
9Caffeine metabolism_Homo sapiens_hsa002322.20820382
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19592218
11Tryptophan metabolism_Homo sapiens_hsa003802.11948516
12Fatty acid degradation_Homo sapiens_hsa000712.04984680
13Asthma_Homo sapiens_hsa053101.98683953
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79729960
15PPAR signaling pathway_Homo sapiens_hsa033201.76502352
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75633475
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75171565
18Sulfur metabolism_Homo sapiens_hsa009201.74236097
19Peroxisome_Homo sapiens_hsa041461.72630273
20Histidine metabolism_Homo sapiens_hsa003401.68840502
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.60682578
22Chemical carcinogenesis_Homo sapiens_hsa052041.56053628
23Linoleic acid metabolism_Homo sapiens_hsa005911.51190871
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50070292
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47986228
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43000147
27Leishmaniasis_Homo sapiens_hsa051401.39934276
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39131091
29Fatty acid metabolism_Homo sapiens_hsa012121.37841337
30Bile secretion_Homo sapiens_hsa049761.33626905
31Retinol metabolism_Homo sapiens_hsa008301.31134025
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28945660
33ABC transporters_Homo sapiens_hsa020101.28011664
34Propanoate metabolism_Homo sapiens_hsa006401.27949252
35beta-Alanine metabolism_Homo sapiens_hsa004101.26982555
36Butanoate metabolism_Homo sapiens_hsa006501.26917632
37Starch and sucrose metabolism_Homo sapiens_hsa005001.23064414
38Phenylalanine metabolism_Homo sapiens_hsa003601.19815774
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15814557
40Steroid biosynthesis_Homo sapiens_hsa001001.13691156
41Sphingolipid metabolism_Homo sapiens_hsa006001.13476204
42Type I diabetes mellitus_Homo sapiens_hsa049401.11137394
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.07797900
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07414444
45Pertussis_Homo sapiens_hsa051331.06788270
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.02661317
47Renin-angiotensin system_Homo sapiens_hsa046141.01655727
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00909395
49Malaria_Homo sapiens_hsa051441.00208472
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99593320
51Fat digestion and absorption_Homo sapiens_hsa049750.98784843
52Vitamin digestion and absorption_Homo sapiens_hsa049770.97586163
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96754744
54Legionellosis_Homo sapiens_hsa051340.94626448
55Graft-versus-host disease_Homo sapiens_hsa053320.94379430
56Tyrosine metabolism_Homo sapiens_hsa003500.93864822
57Osteoclast differentiation_Homo sapiens_hsa043800.93630250
58Selenocompound metabolism_Homo sapiens_hsa004500.85620068
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85460356
60Allograft rejection_Homo sapiens_hsa053300.85206465
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.84794560
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84017092
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83733032
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.83643025
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82975003
66Ether lipid metabolism_Homo sapiens_hsa005650.81119275
67Measles_Homo sapiens_hsa051620.80608324
68Fatty acid elongation_Homo sapiens_hsa000620.80547961
69TNF signaling pathway_Homo sapiens_hsa046680.77633652
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77271792
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77110523
72Arachidonic acid metabolism_Homo sapiens_hsa005900.76910865
73Viral myocarditis_Homo sapiens_hsa054160.76746948
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.75599549
75Lysosome_Homo sapiens_hsa041420.75079173
76Toxoplasmosis_Homo sapiens_hsa051450.74968903
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.73084191
78Folate biosynthesis_Homo sapiens_hsa007900.71595245
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69101514
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68683743
81Dorso-ventral axis formation_Homo sapiens_hsa043200.64905482
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64896403
83African trypanosomiasis_Homo sapiens_hsa051430.64742034
84Tuberculosis_Homo sapiens_hsa051520.64727218
85Prion diseases_Homo sapiens_hsa050200.62767848
86Hepatitis C_Homo sapiens_hsa051600.62499441
87Influenza A_Homo sapiens_hsa051640.61444489
88Chemokine signaling pathway_Homo sapiens_hsa040620.61363246
89Other glycan degradation_Homo sapiens_hsa005110.61261024
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.61157187
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57544592
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57208744
93Amoebiasis_Homo sapiens_hsa051460.56222445
94Dilated cardiomyopathy_Homo sapiens_hsa054140.55676852
95Protein digestion and absorption_Homo sapiens_hsa049740.52267288
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51790179
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51352804
98Insulin resistance_Homo sapiens_hsa049310.50443274
99Fatty acid biosynthesis_Homo sapiens_hsa000610.49593089
100Mineral absorption_Homo sapiens_hsa049780.49211067
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48284920
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.46586247
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46259351
104B cell receptor signaling pathway_Homo sapiens_hsa046620.45864835
105Rheumatoid arthritis_Homo sapiens_hsa053230.45651515
106Arginine and proline metabolism_Homo sapiens_hsa003300.45372995
107Pyruvate metabolism_Homo sapiens_hsa006200.44863955
108Ovarian steroidogenesis_Homo sapiens_hsa049130.44145369
109Hematopoietic cell lineage_Homo sapiens_hsa046400.43779004
110Lysine degradation_Homo sapiens_hsa003100.43325531
111Phagosome_Homo sapiens_hsa041450.42140601
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41761250
113Glycerolipid metabolism_Homo sapiens_hsa005610.41556121
114Bladder cancer_Homo sapiens_hsa052190.41027919
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39629893
116Carbon metabolism_Homo sapiens_hsa012000.38822919
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38582198
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37119185
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.36006892
120Glutathione metabolism_Homo sapiens_hsa004800.35907521
121Apoptosis_Homo sapiens_hsa042100.35531117
122Galactose metabolism_Homo sapiens_hsa000520.35256254
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34948900
124Salmonella infection_Homo sapiens_hsa051320.34801421
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.33234284
126Autoimmune thyroid disease_Homo sapiens_hsa053200.31782193
127Herpes simplex infection_Homo sapiens_hsa051680.30283977
128Antigen processing and presentation_Homo sapiens_hsa046120.30174204

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