SPPL2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.68095804
2axonemal dynein complex assembly (GO:0070286)9.67346221
3epithelial cilium movement (GO:0003351)9.64340291
4plasma membrane fusion (GO:0045026)9.43279794
5regulation of cilium movement (GO:0003352)9.15778098
6reproduction (GO:0000003)8.99057609
7negative regulation of inclusion body assembly (GO:0090084)7.95274548
8cilium movement (GO:0003341)7.69579872
9cilium or flagellum-dependent cell motility (GO:0001539)7.68223179
10protein targeting to Golgi (GO:0000042)7.45698790
11response to pheromone (GO:0019236)7.27174617
12sperm capacitation (GO:0048240)7.26188230
13establishment of protein localization to Golgi (GO:0072600)7.16516650
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.11820601
15single fertilization (GO:0007338)7.11021935
16organic cation transport (GO:0015695)7.10517783
17spermatogenesis (GO:0007283)7.06184648
18synaptonemal complex organization (GO:0070193)7.05665113
19male gamete generation (GO:0048232)7.03568963
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.95676188
21rRNA methylation (GO:0031167)6.93646325
22synaptonemal complex assembly (GO:0007130)6.89044433
23microtubule depolymerization (GO:0007019)6.78101449
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.76654064
25piRNA metabolic process (GO:0034587)6.65343974
26male meiosis (GO:0007140)6.59021634
27regulation of inclusion body assembly (GO:0090083)6.54435632
28gamete generation (GO:0007276)6.46376305
29phosphatidylethanolamine metabolic process (GO:0046337)6.29706548
30fertilization (GO:0009566)6.12025550
31chromosome condensation (GO:0030261)6.04616008
32calcium ion-dependent exocytosis (GO:0017156)5.87983647
33centriole replication (GO:0007099)5.82059068
34rRNA modification (GO:0000154)5.79039651
35DNA packaging (GO:0006323)5.72787795
36germ cell development (GO:0007281)5.55938971
37regulation of microtubule-based movement (GO:0060632)5.41439144
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.40594084
39protein localization to Golgi apparatus (GO:0034067)5.35375944
40glycerol ether metabolic process (GO:0006662)5.26948977
41spermatid nucleus differentiation (GO:0007289)5.22072776
42centriole assembly (GO:0098534)5.18087986
43multicellular organismal reproductive process (GO:0048609)5.08718932
44cellular ketone body metabolic process (GO:0046950)5.04110251
45cell recognition (GO:0008037)5.01495094
46ventricular system development (GO:0021591)4.99357240
47microtubule severing (GO:0051013)4.90527940
48positive regulation of Rab GTPase activity (GO:0032851)4.89128888
49regulation of Rab GTPase activity (GO:0032313)4.89128888
50ether metabolic process (GO:0018904)4.86969196
51sexual reproduction (GO:0019953)4.77836429
52male meiosis I (GO:0007141)4.74733810
53regulation of centriole replication (GO:0046599)4.74622987
54seminiferous tubule development (GO:0072520)4.70616176
55regulation of transcription involved in cell fate commitment (GO:0060850)4.64638220
56chromosome organization involved in meiosis (GO:0070192)4.60374745
57left/right pattern formation (GO:0060972)4.56124472
58single strand break repair (GO:0000012)4.46733794
59ketone body metabolic process (GO:1902224)4.44106290
60chaperone-mediated protein complex assembly (GO:0051131)4.26858688
61DNA methylation involved in gamete generation (GO:0043046)4.25035031
62multicellular organismal development (GO:0007275)4.10667956
63musculoskeletal movement (GO:0050881)4.04128051
64multicellular organismal movement (GO:0050879)4.04128051
65meiotic nuclear division (GO:0007126)4.02673607
66regulation of interleukin-13 production (GO:0032656)3.92814655
67meiosis I (GO:0007127)3.77318721
68microtubule nucleation (GO:0007020)3.76072662
69sequestering of actin monomers (GO:0042989)3.65935683
70protein polyglutamylation (GO:0018095)3.63084322
71response to acidic pH (GO:0010447)3.58882353
72glomerular visceral epithelial cell development (GO:0072015)3.57148499
73regulation of spindle checkpoint (GO:0090231)3.56158840
74protein refolding (GO:0042026)3.54731125
75cellular response to pH (GO:0071467)3.48402170
76microtubule polymerization or depolymerization (GO:0031109)3.46111012
77glomerular epithelial cell development (GO:0072310)3.41302569
78genitalia morphogenesis (GO:0035112)3.40497705
79protein K11-linked deubiquitination (GO:0035871)3.36942315
80RNA destabilization (GO:0050779)3.31432484
81interferon-gamma secretion (GO:0072643)3.30496751
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30295924
83cerebral cortex neuron differentiation (GO:0021895)3.27832594
84RNA localization (GO:0006403)3.26731755
85nucleus organization (GO:0006997)3.25755396
86peptidyl-threonine dephosphorylation (GO:0035970)3.25611158
87meiotic cell cycle (GO:0051321)3.25528263
88glycolytic process (GO:0006096)3.25174432
89carnitine transport (GO:0015879)3.22486927
90amino-acid betaine transport (GO:0015838)3.22486927
91mitotic sister chromatid cohesion (GO:0007064)3.22282913
92negative regulation of Rho protein signal transduction (GO:0035024)3.22192212
93protein depolymerization (GO:0051261)3.18579854
94coenzyme catabolic process (GO:0009109)3.18054966
95polyamine biosynthetic process (GO:0006596)3.14778572
96positive regulation of macrophage activation (GO:0043032)3.10324677
97homeostasis of number of cells within a tissue (GO:0048873)3.09087043
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03414623
99protein localization to cilium (GO:0061512)3.03316858
100carnitine transmembrane transport (GO:1902603)3.03077689
101chromatin silencing (GO:0006342)2.99916656
102Golgi to endosome transport (GO:0006895)2.99763337
103positive regulation of guanylate cyclase activity (GO:0031284)2.98647002
104nucleoside diphosphate phosphorylation (GO:0006165)2.97087467
105histone H3-K9 demethylation (GO:0033169)2.96128117
106polyol catabolic process (GO:0046174)2.95705898
107regulation of phosphoprotein phosphatase activity (GO:0043666)2.87718949
108regulation of T-helper 2 cell differentiation (GO:0045628)2.86336409
109alditol metabolic process (GO:0019400)2.85410663
110mitochondrion degradation (GO:0000422)2.84858120
111mitochondrial fission (GO:0000266)2.82486351
112regulation of guanylate cyclase activity (GO:0031282)2.82464795
113regulation of cilium assembly (GO:1902017)2.81325649
114vesicle transport along microtubule (GO:0047496)2.79579016
115nuclear pore complex assembly (GO:0051292)2.78775631
116regulation of ARF GTPase activity (GO:0032312)2.78334793
117monoubiquitinated protein deubiquitination (GO:0035520)2.76922309
118mitotic G1 DNA damage checkpoint (GO:0031571)2.76876043
119intra-Golgi vesicle-mediated transport (GO:0006891)2.75213146
120meiotic cell cycle process (GO:1903046)2.70311793
121receptor recycling (GO:0001881)2.69769394
122cilium organization (GO:0044782)2.68203287
123protein-DNA complex disassembly (GO:0032986)2.65474010
124nucleosome disassembly (GO:0006337)2.65474010
125GTP biosynthetic process (GO:0006183)2.60431931
126synapsis (GO:0007129)2.59994231
127peptidyl-glutamic acid modification (GO:0018200)2.59907116
128microtubule-based movement (GO:0007018)2.57956857
129cilium assembly (GO:0042384)2.57954704
130cilium morphogenesis (GO:0060271)2.56360785
131cellular component assembly involved in morphogenesis (GO:0010927)2.54831312
132positive regulation of glycolytic process (GO:0045821)2.52246952
133axoneme assembly (GO:0035082)2.44222096
134cellular response to arsenic-containing substance (GO:0071243)2.41536360
135negative regulation of skeletal muscle tissue development (GO:0048642)2.40799753
136sperm motility (GO:0030317)14.5938829
137acrosome reaction (GO:0007340)13.0489303
138cell wall macromolecule catabolic process (GO:0016998)12.7092462
139cell wall macromolecule metabolic process (GO:0044036)12.7092462
140fusion of sperm to egg plasma membrane (GO:0007342)12.3895686
141sperm-egg recognition (GO:0035036)11.5288289
142acrosome assembly (GO:0001675)11.0560010
143binding of sperm to zona pellucida (GO:0007339)10.6128847
144cell-cell recognition (GO:0009988)10.3166660
145multicellular organism reproduction (GO:0032504)10.1940651
146spermatid development (GO:0007286)10.0714479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.95057405
2EZH2_22144423_ChIP-Seq_EOC_Human4.28756419
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01814955
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.94355754
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60312739
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07394739
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94571756
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85751063
9VDR_22108803_ChIP-Seq_LS180_Human2.65616750
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49096066
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.39908932
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28615036
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26821527
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14085804
15DROSHA_22980978_ChIP-Seq_HELA_Human2.11879499
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06182087
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02450928
18FUS_26573619_Chip-Seq_HEK293_Human1.99688503
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99164717
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.97283387
21ZNF274_21170338_ChIP-Seq_K562_Hela1.95793565
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86026178
23RAC3_21632823_ChIP-Seq_H3396_Human1.79664602
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78935692
25ERA_21632823_ChIP-Seq_H3396_Human1.73812606
26SOX2_22085726_ChIP-Seq_NPCs_Mouse1.72696831
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72491985
28STAT1_17558387_ChIP-Seq_HELA_Human1.71935216
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70705521
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.70069571
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63856004
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61603388
33GATA3_21867929_ChIP-Seq_CD8_Mouse1.61160630
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59387424
35FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56599700
36TAF2_19829295_ChIP-Seq_ESCs_Human1.54820740
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.51887519
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50277963
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49657934
40MYC_19829295_ChIP-Seq_ESCs_Human1.49616740
41SMC4_20622854_ChIP-Seq_HELA_Human1.48959888
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.47457810
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.46116473
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46092159
45ER_23166858_ChIP-Seq_MCF-7_Human1.45372261
46AR_25329375_ChIP-Seq_VCAP_Human1.43188881
47OCT4_20526341_ChIP-Seq_ESCs_Human1.42240885
48P53_21459846_ChIP-Seq_SAOS-2_Human1.40667021
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40224982
50P68_20966046_ChIP-Seq_HELA_Human1.39277095
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39141461
52E2F1_20622854_ChIP-Seq_HELA_Human1.38634434
53KDM2B_26808549_Chip-Seq_REH_Human1.38355269
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.37686254
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36026265
56REST_21632747_ChIP-Seq_MESCs_Mouse1.35654771
57RBPJ_21746931_ChIP-Seq_IB4_Human1.35601843
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35251913
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35174355
60HNFA_21074721_ChIP-Seq_CACO-2_Human1.34673963
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34576839
62CBP_20019798_ChIP-Seq_JUKART_Human1.34576839
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.33722572
64TP53_18474530_ChIP-ChIP_U2OS_Human1.33143250
65LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33009147
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32659926
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32456702
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32430497
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.32257032
70TP63_22573176_ChIP-Seq_HFKS_Human1.31989078
71ETV1_20927104_ChIP-Seq_GIST48_Human1.30486912
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29819831
73RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29728729
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.28768904
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28662929
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25861528
77CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25793325
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.25460634
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24212669
80GF1_26923725_Chip-Seq_HPCs_Mouse1.24108169
81P300_19829295_ChIP-Seq_ESCs_Human1.23676264
82P300_27268052_Chip-Seq_Bcells_Human1.23086558
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22961145
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22703162
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21256540
86LXR_22292898_ChIP-Seq_THP-1_Human1.21150997
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21060899
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.20564785
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19631279
90SPI1_26923725_Chip-Seq_HPCs_Mouse1.18728071
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18607450
92TBL1_22424771_ChIP-Seq_293T_Human1.18021209
93CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17897558
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.17309597
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16903624
96MYC_27129775_Chip-Seq_CORNEA_Mouse1.16695506
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14948469
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.14598571
99CEBPB_22108803_ChIP-Seq_LS180_Human1.14246200
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13750550
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13403104
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.12490911
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12165254
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.12113931
105PHF8_20622853_ChIP-Seq_HELA_Human1.12026587
106JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11796505
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11731238
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11731238
109CTCF_20526341_ChIP-Seq_ESCs_Human1.11413994
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11064004
111GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11024151
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.10329787
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10078572
114ERG_20517297_ChIP-Seq_VCAP_Human1.10020252
115RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09875241
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.09792170
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.09612404
118SMAD4_21799915_ChIP-Seq_A2780_Human1.08871205
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.08774227
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07749817
121GATA6_21074721_ChIP-Seq_CACO-2_Human1.07406318
122ESET_19884257_ChIP-Seq_ESCs_Mouse1.06287674
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05917269
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05782948
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.05707927
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.05433113
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05068286
128STAT3_23295773_ChIP-Seq_U87_Human1.04431561
129SA1_27219007_Chip-Seq_Bcells_Human1.04394528
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04113632
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03849100
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03781751
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03600880
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03248549
135RUNX2_22187159_ChIP-Seq_PCA_Human1.02761687
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02130017
137RUNX_20019798_ChIP-Seq_JUKART_Human1.01355089
138ELF1_20517297_ChIP-Seq_JURKAT_Human1.01116454
139BCOR_27268052_Chip-Seq_Bcells_Human1.01048734
140NFYA_21822215_ChIP-Seq_K562_Human1.01042178
141SOX11_22085726_ChIP-Seq_ESNs_Mouse1.01039818
142SMRT_27268052_Chip-Seq_Bcells_Human1.00754814
143KLF4_19829295_ChIP-Seq_ESCs_Human0.99437083
144NANOG_19829295_ChIP-Seq_ESCs_Human0.98669457
145SOX2_19829295_ChIP-Seq_ESCs_Human0.98669457
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97686222
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97359462
148LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96319972
149SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95698804
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94826665
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.94068336
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.93358868
153NANOG_20526341_ChIP-Seq_ESCs_Human0.93038555
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92681140
155RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92423071
156CTCF_27219007_Chip-Seq_Bcells_Human0.91901409
157NFYB_21822215_ChIP-Seq_K562_Human0.91884231
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91040123
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90923688
160BCL6_27268052_Chip-Seq_Bcells_Human0.89823820
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89710354
162TAF15_26573619_Chip-Seq_HEK293_Human0.89497882
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.88992613
164PHF8_20622854_ChIP-Seq_HELA_Human0.88482845
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88019979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02681763
2MP0001929_abnormal_gametogenesis5.46849210
3MP0001348_abnormal_lacrimal_gland4.10018077
4MP0008877_abnormal_DNA_methylation3.67117135
5MP0005670_abnormal_white_adipose3.34359394
6MP0002161_abnormal_fertility/fecundity3.30370384
7MP0002210_abnormal_sex_determination3.21268195
8MP0001145_abnormal_male_reproductive2.72862667
9MP0000653_abnormal_sex_gland2.34668764
10MP0003718_maternal_effect2.04330967
11MP0005410_abnormal_fertilization16.8530059
12MP0000678_abnormal_parathyroid_gland1.94635312
13MP0002653_abnormal_ependyma_morphology1.94380472
14MP0004859_abnormal_synaptic_plasticity1.88594714
15MP0001485_abnormal_pinna_reflex1.81471618
16MP0005310_abnormal_salivary_gland1.76050894
17MP0001486_abnormal_startle_reflex1.75991483
18MP0003646_muscle_fatigue1.61622472
19MP0005379_endocrine/exocrine_gland_phen1.55415888
20MP0004233_abnormal_muscle_weight1.49206727
21MP0005451_abnormal_body_composition1.48574936
22MP0002160_abnormal_reproductive_system1.41147601
23MP0002132_abnormal_respiratory_system1.40539171
24MP0002735_abnormal_chemical_nociception1.35043955
25MP0002249_abnormal_larynx_morphology1.21332747
26MP0001963_abnormal_hearing_physiology1.20942817
27MP0005623_abnormal_meninges_morphology1.18012515
28MP0002282_abnormal_trachea_morphology1.11497323
29MP0001765_abnormal_ion_homeostasis1.10935567
30MP0004510_myositis1.07945398
31MP0009053_abnormal_anal_canal1.07122614
32MP0002138_abnormal_hepatobiliary_system1.03550856
33MP0001984_abnormal_olfaction1.00434451
34MP0000026_abnormal_inner_ear0.98783490
35MP0002234_abnormal_pharynx_morphology0.96719674
36MP0000955_abnormal_spinal_cord0.96231092
37MP0001873_stomach_inflammation0.96035104
38MP0002067_abnormal_sensory_capabilities0.89422813
39MP0005395_other_phenotype0.87452960
40MP0002557_abnormal_social/conspecific_i0.84919129
41MP0002127_abnormal_cardiovascular_syste0.84123108
42MP0003115_abnormal_respiratory_system0.82620527
43MP0009745_abnormal_behavioral_response0.81872377
44MP0003880_abnormal_central_pattern0.81271759
45MP0002572_abnormal_emotion/affect_behav0.77901082
46MP0001905_abnormal_dopamine_level0.76936522
47MP0001440_abnormal_grooming_behavior0.76469185
48MP0005647_abnormal_sex_gland0.74051032
49MP0002272_abnormal_nervous_system0.73875722
50MP0005083_abnormal_biliary_tract0.73546040
51MP0002733_abnormal_thermal_nociception0.72941723
52MP0005666_abnormal_adipose_tissue0.71734340
53MP0005167_abnormal_blood-brain_barrier0.70335070
54MP0003635_abnormal_synaptic_transmissio0.70171229
55MP0005389_reproductive_system_phenotype0.67354321
56MP0008995_early_reproductive_senescence0.66258404
57MP0005248_abnormal_Harderian_gland0.65641038
58MP0002734_abnormal_mechanical_nocicepti0.65310481
59MP0008058_abnormal_DNA_repair0.65159113
60MP0003329_amyloid_beta_deposits0.64197227
61MP0003011_delayed_dark_adaptation0.63404903
62MP0003878_abnormal_ear_physiology0.63350724
63MP0005377_hearing/vestibular/ear_phenot0.63350724
64MP0004085_abnormal_heartbeat0.62575948
65MP0005636_abnormal_mineral_homeostasis0.61710109
66MP0009046_muscle_twitch0.61608375
67MP0009697_abnormal_copulation0.61517252
68MP0000049_abnormal_middle_ear0.56754504
69MP0001970_abnormal_pain_threshold0.55483080
70MP0001501_abnormal_sleep_pattern0.54457649
71MP0004036_abnormal_muscle_relaxation0.54126683
72MP0001879_abnormal_lymphatic_vessel0.53323747
73MP0002736_abnormal_nociception_after0.52885293
74MP0001764_abnormal_homeostasis0.52199362
75MP0002269_muscular_atrophy0.50823773
76MP0000681_abnormal_thyroid_gland0.50022900
77MP0000534_abnormal_ureter_morphology0.49763579
78MP0001324_abnormal_eye_pigmentation0.49276858
79MP0003137_abnormal_impulse_conducting0.48529575
80MP0004484_altered_response_of0.47005014
81MP0001293_anophthalmia0.46044837
82MP0002063_abnormal_learning/memory/cond0.45658439
83MP0000358_abnormal_cell_content/0.45381949
84MP0005535_abnormal_body_temperature0.43890827
85MP0001666_abnormal_nutrient_absorption0.43696390
86MP0003699_abnormal_female_reproductive0.43495691
87MP0009278_abnormal_bone_marrow0.43332115
88MP0004084_abnormal_cardiac_muscle0.42970692
89MP0006036_abnormal_mitochondrial_physio0.42574909
90MP0001545_abnormal_hematopoietic_system0.42382147
91MP0005397_hematopoietic_system_phenotyp0.42382147
92MP0000230_abnormal_systemic_arterial0.41316299
93MP0002882_abnormal_neuron_morphology0.41277699
94MP0009115_abnormal_fat_cell0.39149480
95MP0003942_abnormal_urinary_system0.38339014
96MP0002064_seizures0.38130277
97MP0005253_abnormal_eye_physiology0.38047705
98MP0010329_abnormal_lipoprotein_level0.38019241
99MP0003077_abnormal_cell_cycle0.37930937
100MP0000516_abnormal_urinary_system0.37374674
101MP0005367_renal/urinary_system_phenotyp0.37374674
102MP0000569_abnormal_digit_pigmentation0.35324132
103MP0005166_decreased_susceptibility_to0.35031203
104MP0004133_heterotaxia0.34125605
105MP0003950_abnormal_plasma_membrane0.33961316
106MP0002184_abnormal_innervation0.33749429
107MP0000470_abnormal_stomach_morphology0.33204148
108MP0000003_abnormal_adipose_tissue0.32878969
109MP0005551_abnormal_eye_electrophysiolog0.32845806
110MP0002928_abnormal_bile_duct0.32664163
111MP0000604_amyloidosis0.32348144
112MP0004811_abnormal_neuron_physiology0.30944454
113MP0002971_abnormal_brown_adipose0.30513365
114MP0003879_abnormal_hair_cell0.30403938
115MP0001968_abnormal_touch/_nociception0.29957093
116MP0010094_abnormal_chromosome_stability0.29170448
117MP0005391_vision/eye_phenotype0.28884179
118MP0003111_abnormal_nucleus_morphology0.28133535
119MP0002139_abnormal_hepatobiliary_system0.27822611
120MP0001849_ear_inflammation0.27756954
121MP0003633_abnormal_nervous_system0.27455400
122MP0005375_adipose_tissue_phenotype0.26782887
123MP0002295_abnormal_pulmonary_circulatio0.26610629
124MP0003948_abnormal_gas_homeostasis0.26384255
125MP0004742_abnormal_vestibular_system0.25784564
126MP0002169_no_abnormal_phenotype0.25542886
127MP0002873_normal_phenotype0.25319479
128MP0006035_abnormal_mitochondrial_morpho0.24578377
129MP0001730_embryonic_growth_arrest0.24562008
130MP0003861_abnormal_nervous_system0.24473836
131MP0003631_nervous_system_phenotype0.22543592
132MP0002152_abnormal_brain_morphology0.22211863
133MP0008961_abnormal_basal_metabolism0.21452926
134MP0004270_analgesia0.21036597
135MP0003787_abnormal_imprinting0.20216906
136MP0004145_abnormal_muscle_electrophysio0.19557528
137MP0000751_myopathy0.19300320
138MP0001119_abnormal_female_reproductive0.19104895
139MP0001727_abnormal_embryo_implantation0.18799346
140MP0004019_abnormal_vitamin_homeostasis0.18743858
141MP0005423_abnormal_somatic_nervous0.18490836
142MP0001986_abnormal_taste_sensitivity0.18000181
143MP0008569_lethality_at_weaning0.17235749
144MP0003959_abnormal_lean_body0.17111485
145MP0008875_abnormal_xenobiotic_pharmacok0.15622791
146MP0002229_neurodegeneration0.15418281
147MP0000001_mammalian_phenotype0.15311860
148MP0002092_abnormal_eye_morphology0.15224967
149MP0004043_abnormal_pH_regulation0.15138241
150MP0002693_abnormal_pancreas_physiology0.14697731
151MP0002118_abnormal_lipid_homeostasis0.14578049
152MP0002822_catalepsy0.14507932
153MP0000462_abnormal_digestive_system0.14140347
154MP0001661_extended_life_span0.14090685
155MP0002909_abnormal_adrenal_gland0.13522002
156MP0005365_abnormal_bile_salt0.12998489
157MP0008770_decreased_survivor_rate0.12810355
158MP0004130_abnormal_muscle_cell0.12095535
159MP0002796_impaired_skin_barrier0.12060265

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.28467270
2Abnormal respiratory epithelium morphology (HP:0012253)9.28467270
3Abnormal respiratory motile cilium physiology (HP:0012261)9.09722957
4Severe visual impairment (HP:0001141)7.68756676
5Infertility (HP:0000789)7.30691051
6Chronic bronchitis (HP:0004469)7.24704789
7Rhinitis (HP:0012384)7.22956290
8Abnormal ciliary motility (HP:0012262)6.95960304
9Nasal polyposis (HP:0100582)6.43311606
10Chronic hepatic failure (HP:0100626)5.82057299
11Abnormality of the nasal mucosa (HP:0000433)5.29423160
12Male infertility (HP:0003251)5.26347109
13Bony spicule pigmentary retinopathy (HP:0007737)4.86118885
14Hyperkalemia (HP:0002153)4.78636039
15Attenuation of retinal blood vessels (HP:0007843)4.75807556
16Resting tremor (HP:0002322)4.68383065
17Bronchitis (HP:0012387)4.59981700
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.46410369
19Bronchiectasis (HP:0002110)4.34278747
20Abnormality of macular pigmentation (HP:0008002)4.14344372
21Cone-rod dystrophy (HP:0000548)4.08738304
22Nephronophthisis (HP:0000090)4.04007649
23Abnormal spermatogenesis (HP:0008669)3.85085244
24Potter facies (HP:0002009)3.72490116
25Facial shape deformation (HP:0011334)3.72490116
26Abnormal rod and cone electroretinograms (HP:0008323)3.68088296
27Hypoplasia of the thymus (HP:0000778)3.58374709
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.54580144
29Hypoalphalipoproteinemia (HP:0003233)3.54361044
30Progressive sensorineural hearing impairment (HP:0000408)3.52818567
31Enlarged epiphyses (HP:0010580)3.52522943
32Postural instability (HP:0002172)3.36631821
33Menstrual irregularities (HP:0000858)3.28898578
34Recurrent otitis media (HP:0000403)3.28550617
35Hypoplastic ischia (HP:0003175)3.26432764
36Renovascular hypertension (HP:0100817)3.24055714
37Progressive cerebellar ataxia (HP:0002073)3.18955968
38Recurrent sinusitis (HP:0011108)3.05141891
39Abnormality of the renal medulla (HP:0100957)2.99749240
40Impulsivity (HP:0100710)2.98767590
41Amelogenesis imperfecta (HP:0000705)2.97466819
42Abnormality of the ischium (HP:0003174)2.95459587
43Portal hypertension (HP:0001409)2.93439540
44Insulin-resistant diabetes mellitus (HP:0000831)2.92084996
45Abnormal gallbladder physiology (HP:0012438)2.83641547
46Cholecystitis (HP:0001082)2.83641547
47Recurrent bronchitis (HP:0002837)2.83499641
48Abnormality of dental color (HP:0011073)2.83479672
49Unilateral renal agenesis (HP:0000122)2.76207009
50Abnormality of the hepatic vasculature (HP:0006707)2.68835536
51Tubulointerstitial nephritis (HP:0001970)2.67306891
52Abnormality of potassium homeostasis (HP:0011042)2.66594526
53Generalized aminoaciduria (HP:0002909)2.63735458
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.59974656
55Tubular atrophy (HP:0000092)2.52587177
56Myokymia (HP:0002411)2.48713823
57Molar tooth sign on MRI (HP:0002419)2.42635428
58Abnormality of midbrain morphology (HP:0002418)2.42635428
59Abnormality of the aortic arch (HP:0012303)2.41048615
60Abnormality of the costochondral junction (HP:0000919)2.40330705
61Dyschromatopsia (HP:0007641)2.37581332
62Gonadotropin excess (HP:0000837)2.37389927
63Tubulointerstitial abnormality (HP:0001969)2.35873410
64Choroideremia (HP:0001139)2.27499242
65Hyperuricemia (HP:0002149)2.27178282
66Increased purine levels (HP:0004368)2.27178282
67Azoospermia (HP:0000027)2.24384648
68Progressive hearing impairment (HP:0001730)2.22837727
69Spastic tetraparesis (HP:0001285)2.18412998
70Medial flaring of the eyebrow (HP:0010747)2.14324593
71Polyuria (HP:0000103)2.12495321
72Osteomalacia (HP:0002749)2.09394281
73Focal segmental glomerulosclerosis (HP:0000097)2.07495190
74Subcapsular cataract (HP:0000523)2.05504667
75Decreased central vision (HP:0007663)2.04815848
76Recurrent pneumonia (HP:0006532)2.02546638
77Flattened epiphyses (HP:0003071)2.02224064
78Intellectual disability, moderate (HP:0002342)2.01321973
79Dynein arm defect of respiratory motile cilia (HP:0012255)13.4911916
80Absent/shortened dynein arms (HP:0200106)13.4911916
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6997401
82Ventricular tachycardia (HP:0004756)1.99789625
83Hypophosphatemic rickets (HP:0004912)1.99659274
84Tubulointerstitial fibrosis (HP:0005576)1.96514393
85Hemorrhage of the eye (HP:0011885)1.96078362
86Epiphyseal dysplasia (HP:0002656)1.92659050
87Neurofibrillary tangles (HP:0002185)1.91872813
88Double outlet right ventricle (HP:0001719)1.91351291
89Congenital malformation of the right heart (HP:0011723)1.91351291
90Widely patent fontanelles and sutures (HP:0004492)1.91338241
91Renal Fanconi syndrome (HP:0001994)1.87705552
92Optic nerve hypoplasia (HP:0000609)1.87623325
93Hyponatremia (HP:0002902)1.84804550
94Abnormality of the epiphysis of the femoral head (HP:0010574)1.84757369
95Abnormality of the pubic bones (HP:0003172)1.84263592
96Occipital encephalocele (HP:0002085)1.83563993
97Abnormality of the parathyroid morphology (HP:0011766)1.80600692
98Heterotopia (HP:0002282)1.80539596
99Bradycardia (HP:0001662)1.76209064
100Abnormal drinking behavior (HP:0030082)1.75400161
101Polydipsia (HP:0001959)1.75400161
102Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75196382
103Insulin resistance (HP:0000855)1.74747518
104Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71229671
105Abnormality of femoral epiphyses (HP:0006499)1.71229671
106Abnormal biliary tract physiology (HP:0012439)1.70257724
107Bile duct proliferation (HP:0001408)1.70257724
108Hypolipoproteinemia (HP:0010981)1.69646573
109Abnormality of chloride homeostasis (HP:0011422)1.69632984
110Postaxial foot polydactyly (HP:0001830)1.69174940
111Photophobia (HP:0000613)1.68559665
112Recurrent corneal erosions (HP:0000495)1.68424755
113Stage 5 chronic kidney disease (HP:0003774)1.68215302
114Congenital sensorineural hearing impairment (HP:0008527)1.67491353
115Bell-shaped thorax (HP:0001591)1.66209308
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64683602
117Abnormality of renal excretion (HP:0011036)1.60405650
118Congenital hepatic fibrosis (HP:0002612)1.57987642
119Cerebral inclusion bodies (HP:0100314)1.56706643
120Asymmetric septal hypertrophy (HP:0001670)1.56310208
121Exercise-induced myalgia (HP:0003738)1.55435954
122Easy fatigability (HP:0003388)1.51028381
123Short ribs (HP:0000773)1.50651091
124Bundle branch block (HP:0011710)1.50229471
125Aplasia/Hypoplasia of the lens (HP:0008063)1.49719598
126Abnormality of the renal cortex (HP:0011035)1.46619972
127Abnormality of dentin (HP:0010299)1.44919995
128Myoglobinuria (HP:0002913)1.44175955
129Oculomotor apraxia (HP:0000657)1.44022791
130Hypercholesterolemia (HP:0003124)1.43670174
131Loss of speech (HP:0002371)1.41755242
132Abnormal urine output (HP:0012590)1.39864063
133Renal dysplasia (HP:0000110)1.38923354
134Hemiparesis (HP:0001269)1.37902653
135Sensory axonal neuropathy (HP:0003390)1.33850664
136Postaxial hand polydactyly (HP:0001162)1.32666230
137Abnormality of the neuromuscular junction (HP:0003398)1.32625312
138Fatigable weakness (HP:0003473)1.32625312
139Abnormality of permanent molar morphology (HP:0011071)1.32352235
140Abnormality of the dental root (HP:0006486)1.32352235
141Taurodontia (HP:0000679)1.32352235
142Constricted visual fields (HP:0001133)1.31836607
143Rhabdomyolysis (HP:0003201)1.31006644
144Deformed sella turcica (HP:0002681)1.29963563
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29442793
146Absent epiphyses (HP:0010577)1.29442793
147Abnormality of the dental pulp (HP:0006479)1.29065783
148Neoplasm of the heart (HP:0100544)1.28438324
149Facial cleft (HP:0002006)1.26786164
150Cerebellar dysplasia (HP:0007033)1.25807330
151Cystic liver disease (HP:0006706)1.25770410
152Broad distal phalanx of finger (HP:0009836)1.24033629
153Abnormality of molar (HP:0011077)1.21785672
154Abnormality of molar morphology (HP:0011070)1.21785672
155Exercise-induced muscle cramps (HP:0003710)1.20032752
156Generalized muscle weakness (HP:0003324)1.20019948
157Truncal obesity (HP:0001956)1.19998592
158Short femoral neck (HP:0100864)1.19899169
159Fibular hypoplasia (HP:0003038)1.19449459
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18757659
161Retinal dysplasia (HP:0007973)1.18715459
162EMG: neuropathic changes (HP:0003445)1.16200048
163Polymicrogyria (HP:0002126)1.15565182
164Nephropathy (HP:0000112)1.14397895
165Abnormal connection of the cardiac segments (HP:0011545)1.13741787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.50111960
2PDK37.50111960
3TESK17.14121000
4PRKD35.99302806
5ICK5.09886812
6PDK24.82952608
7DDR24.25031157
8BRD44.08614703
9INSRR4.07903785
10PLK23.25409253
11MAP4K22.81744348
12PTK2B2.14816124
13PIK3CG2.10922027
14STK382.06537945
15WNK42.03156990
16STK391.94819182
17DYRK1B1.81725030
18PNCK1.65980554
19MST1R1.64666584
20NEK21.58096562
21CDK121.29538429
22PDK11.26778161
23AKT31.12811419
24CDK71.03449523
25DYRK30.96313881
26CAMK1D0.92620836
27MAPK150.90903287
28KSR20.90651537
29PDPK10.87632483
30MAP3K90.87278342
31SIK20.85842275
32RIPK40.85445250
33TYRO30.83105674
34EEF2K0.77307110
35MAP3K110.76360145
36IRAK10.76061945
37WNK10.75464817
38MARK10.70544120
39PASK0.70498139
40UHMK10.70214561
41NTRK30.70082721
42PBK0.68948282
43TESK20.67519699
44RPS6KA20.64690318
45PINK10.62545618
46CCNB10.62376617
47CAMK10.62159017
48TNIK0.61834926
49MAP2K20.61614986
50STK30.57526680
51CDK30.56266266
52MUSK0.55921926
53LATS20.55543018
54CHEK20.55353331
55TTK0.55015579
56SGK2230.54726341
57SGK4940.54726341
58MAP2K60.54399583
59MAP3K20.51400645
60ROCK10.50945103
61IRAK20.50442492
62NTRK20.49021940
63CAMK1G0.46456344
64PAK10.43292083
65PRKAA20.42848399
66TIE10.41936775
67MAP3K100.40280195
68MAPK10.38528589
69PRKCG0.37604566
70STK38L0.37512793
71LMTK20.35569896
72CAMK40.34805665
73MAPKAPK50.34375352
74PAK40.33030857
75CHEK10.32682498
76PAK20.31625390
77RPS6KC10.31350476
78RPS6KL10.31350476
79MARK20.30834663
80MAP3K80.30821250
81NME10.30184475
82RPS6KA60.29473424
83SGK10.29300752
84LATS10.27740029
85MET0.26894913
86CAMKK10.26638946
87MTOR0.25862583
88BMPR1B0.24885255
89MAP3K40.22506033
90MAPK100.22431220
91ATM0.22151640
92PRKCZ0.21558608
93MAPK140.19872779
94MINK10.19561466
95FER0.19403984
96BRSK20.19110799
97PRKAA10.19009155
98OXSR10.18601518
99JAK30.18015809
100ATR0.17776460
101NEK60.16835458
102SGK20.16699619
103CDK150.16430569
104PRKCQ0.15326045
105ARAF0.14795703
106CDK180.13735012
107RPS6KB10.12731677
108BRSK10.12723547
109CDK11A0.12443613
110AKT10.12313983
111RPS6KA10.10797885
112MARK30.09875732
113BRAF0.09766861
114PRKG20.09204162
115CDK140.08919201
116CDK50.07586348
117PLK10.07483813
118MAP3K70.07301931
119CLK10.07203914
120GSK3B0.06228741
121CSNK2A10.06141773
122MAPK90.05979170
123STK110.05762127
124PLK40.05411125
125CSF1R0.04658774
126STK100.04639830
127PKN10.04550080
128PIM10.04229222
129PRKCD0.04123045
130CAMK2A0.03579205
131CDK60.03497667
132WEE10.02905621
133PRKG10.01894910
134PRKACG0.01757941
135TRIB30.01727131
136MAPK80.01545470
137EPHB10.01542620
138PRKCB0.01328966
139CDC70.01292407
140CDK20.00939122
141PRKCA0.00487516
142CDK10.00109939
143SRC-0.0581296
144MAP3K5-0.0545477
145ZAP70-0.0445628
146PRKACB-0.0368105
147PRKACA-0.0365742
148MAP3K1-0.0339687
149EGFR-0.0307220
150RPS6KA3-0.0293494
151CDK4-0.0169067
152CSNK2A2-0.0111533
153PAK6-0.0071537
154CSNK1D-0.0057995
155AURKA-0.0021427

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.63635399
2Fatty acid biosynthesis_Homo sapiens_hsa000615.03861625
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43457278
4Olfactory transduction_Homo sapiens_hsa047403.53715033
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.36952686
6Linoleic acid metabolism_Homo sapiens_hsa005913.26498418
7Pyruvate metabolism_Homo sapiens_hsa006203.11413864
8Vitamin B6 metabolism_Homo sapiens_hsa007503.06422634
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.97834888
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.56210120
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54303430
12Glucagon signaling pathway_Homo sapiens_hsa049222.47658204
13Propanoate metabolism_Homo sapiens_hsa006402.30252272
14Butanoate metabolism_Homo sapiens_hsa006502.18762360
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05482439
16Basal transcription factors_Homo sapiens_hsa030221.98413531
17Glycerolipid metabolism_Homo sapiens_hsa005611.98219182
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97888968
19PPAR signaling pathway_Homo sapiens_hsa033201.94896207
20Selenocompound metabolism_Homo sapiens_hsa004501.86398373
21Allograft rejection_Homo sapiens_hsa053301.83762779
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.83303586
23Autoimmune thyroid disease_Homo sapiens_hsa053201.79275866
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.73931200
25Fructose and mannose metabolism_Homo sapiens_hsa000511.72439622
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64473580
27Fat digestion and absorption_Homo sapiens_hsa049751.64432458
28Fatty acid degradation_Homo sapiens_hsa000711.60722279
29Fatty acid metabolism_Homo sapiens_hsa012121.59904261
30Mineral absorption_Homo sapiens_hsa049781.55014171
31Ether lipid metabolism_Homo sapiens_hsa005651.53814169
32Amphetamine addiction_Homo sapiens_hsa050311.50818402
33Oocyte meiosis_Homo sapiens_hsa041141.46757736
34Nicotine addiction_Homo sapiens_hsa050331.42100477
35Dorso-ventral axis formation_Homo sapiens_hsa043201.40418987
36Phenylalanine metabolism_Homo sapiens_hsa003601.36965213
37Cardiac muscle contraction_Homo sapiens_hsa042601.31312989
38Phototransduction_Homo sapiens_hsa047441.30792099
39Morphine addiction_Homo sapiens_hsa050321.27161682
40Carbon metabolism_Homo sapiens_hsa012001.27127852
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23688337
42Pentose phosphate pathway_Homo sapiens_hsa000301.22450275
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.13493281
44Type I diabetes mellitus_Homo sapiens_hsa049401.12420741
45Hedgehog signaling pathway_Homo sapiens_hsa043401.08045461
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07427841
47Antigen processing and presentation_Homo sapiens_hsa046121.05746575
48Renin secretion_Homo sapiens_hsa049241.03291153
49Glutathione metabolism_Homo sapiens_hsa004801.02286618
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01427938
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00420437
52Arginine and proline metabolism_Homo sapiens_hsa003301.00099914
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.98908905
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96778260
55Collecting duct acid secretion_Homo sapiens_hsa049660.94517500
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.93778121
57Purine metabolism_Homo sapiens_hsa002300.93414818
58Fanconi anemia pathway_Homo sapiens_hsa034600.93215813
59Arachidonic acid metabolism_Homo sapiens_hsa005900.92860070
60Insulin secretion_Homo sapiens_hsa049110.88873134
61Arginine biosynthesis_Homo sapiens_hsa002200.88020923
62Chemical carcinogenesis_Homo sapiens_hsa052040.85404222
63GABAergic synapse_Homo sapiens_hsa047270.85043231
64Graft-versus-host disease_Homo sapiens_hsa053320.82320082
65Bile secretion_Homo sapiens_hsa049760.80830397
66mRNA surveillance pathway_Homo sapiens_hsa030150.80524898
67Thyroid hormone synthesis_Homo sapiens_hsa049180.78577513
68Estrogen signaling pathway_Homo sapiens_hsa049150.75433097
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75157777
70Huntingtons disease_Homo sapiens_hsa050160.74553135
71Long-term potentiation_Homo sapiens_hsa047200.73554292
72Biosynthesis of amino acids_Homo sapiens_hsa012300.72327208
73Viral myocarditis_Homo sapiens_hsa054160.71468780
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71293324
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.71271190
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70924322
77Serotonergic synapse_Homo sapiens_hsa047260.66494755
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.64234720
79RNA transport_Homo sapiens_hsa030130.64022469
80Cholinergic synapse_Homo sapiens_hsa047250.63371138
81Systemic lupus erythematosus_Homo sapiens_hsa053220.63207542
82Legionellosis_Homo sapiens_hsa051340.61546054
83Pancreatic secretion_Homo sapiens_hsa049720.61073722
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.59903504
85Salivary secretion_Homo sapiens_hsa049700.59396891
86Influenza A_Homo sapiens_hsa051640.55726244
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54696642
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.52888635
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.52600723
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52309204
91Protein digestion and absorption_Homo sapiens_hsa049740.51361466
92Asthma_Homo sapiens_hsa053100.50692589
93MAPK signaling pathway_Homo sapiens_hsa040100.50544679
94Synaptic vesicle cycle_Homo sapiens_hsa047210.48931266
95Tyrosine metabolism_Homo sapiens_hsa003500.48894251
96Calcium signaling pathway_Homo sapiens_hsa040200.48219014
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47819297
98ABC transporters_Homo sapiens_hsa020100.47735380
99Gastric acid secretion_Homo sapiens_hsa049710.47603041
100Endocytosis_Homo sapiens_hsa041440.47096126
101Renin-angiotensin system_Homo sapiens_hsa046140.46774188
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45984807
103AMPK signaling pathway_Homo sapiens_hsa041520.45607598
104Oxytocin signaling pathway_Homo sapiens_hsa049210.42357385
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42154495
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40253572
107Sulfur metabolism_Homo sapiens_hsa009200.39739576
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39454854
109Tight junction_Homo sapiens_hsa045300.38885442
110Retinol metabolism_Homo sapiens_hsa008300.38149037
111Alcoholism_Homo sapiens_hsa050340.37309348
112Nitrogen metabolism_Homo sapiens_hsa009100.37175955
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37102064
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.36101652
115VEGF signaling pathway_Homo sapiens_hsa043700.35200382
116Metabolic pathways_Homo sapiens_hsa011000.34441499
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33958650
118Inositol phosphate metabolism_Homo sapiens_hsa005620.33711601
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32021995
120cAMP signaling pathway_Homo sapiens_hsa040240.30931984
121Taste transduction_Homo sapiens_hsa047420.29642034
122Circadian entrainment_Homo sapiens_hsa047130.27762691
123Pyrimidine metabolism_Homo sapiens_hsa002400.27363203
124Cocaine addiction_Homo sapiens_hsa050300.26045749
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25083309
126T cell receptor signaling pathway_Homo sapiens_hsa046600.23429016
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23199392
128Acute myeloid leukemia_Homo sapiens_hsa052210.22043948
129Prolactin signaling pathway_Homo sapiens_hsa049170.20676133
130Long-term depression_Homo sapiens_hsa047300.19700155
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18868572
132Basal cell carcinoma_Homo sapiens_hsa052170.17332542
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16687415
134HIF-1 signaling pathway_Homo sapiens_hsa040660.13023923
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10730085
136Wnt signaling pathway_Homo sapiens_hsa043100.10537731
137B cell receptor signaling pathway_Homo sapiens_hsa046620.08266473
138Salmonella infection_Homo sapiens_hsa051320.07035238
139Type II diabetes mellitus_Homo sapiens_hsa049300.06796411
140Glutamatergic synapse_Homo sapiens_hsa047240.05372681

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