SPPL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ventricular trabecula myocardium morphogenesis (GO:0003222)3.95432195
2presynaptic membrane assembly (GO:0097105)3.88809571
3DNA damage induced protein phosphorylation (GO:0006975)3.80283490
4ionotropic glutamate receptor signaling pathway (GO:0035235)3.72968941
5negative regulation of telomere maintenance (GO:0032205)3.71603304
6positive regulation of synapse assembly (GO:0051965)3.70789778
7artery development (GO:0060840)3.62883117
8cerebral cortex radially oriented cell migration (GO:0021799)3.60512087
9negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.60245769
10pyrimidine nucleobase catabolic process (GO:0006208)3.51685666
11pre-miRNA processing (GO:0031054)3.41022847
12presynaptic membrane organization (GO:0097090)3.35418976
13histone H4-K12 acetylation (GO:0043983)3.34180506
14neuron recognition (GO:0008038)3.31141646
15behavioral response to nicotine (GO:0035095)3.27359035
16cerebellar granule cell differentiation (GO:0021707)3.23818961
17cardiac right ventricle morphogenesis (GO:0003215)3.19619787
18heterochromatin organization (GO:0070828)3.16576087
19glycerophospholipid catabolic process (GO:0046475)3.15631032
20regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14555605
21limb bud formation (GO:0060174)3.13913740
22histone H4-K8 acetylation (GO:0043982)3.05954166
23histone H4-K5 acetylation (GO:0043981)3.05954166
24negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.05451875
25glutamate receptor signaling pathway (GO:0007215)3.02095794
26transmission of nerve impulse (GO:0019226)3.00353483
27negative regulation of epidermis development (GO:0045683)2.99225965
28regulation of hippo signaling (GO:0035330)2.96495543
29embryonic foregut morphogenesis (GO:0048617)2.96112290
30dendrite morphogenesis (GO:0048813)2.95975732
31regulation of telomere maintenance (GO:0032204)2.95078329
32G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92896307
33regulation of nuclear cell cycle DNA replication (GO:0033262)2.90758157
34establishment of skin barrier (GO:0061436)2.90721602
35histone H4-K16 acetylation (GO:0043984)2.89795820
36interkinetic nuclear migration (GO:0022027)2.85438207
37response to acidic pH (GO:0010447)2.85403828
38polarized epithelial cell differentiation (GO:0030859)2.84829684
39urinary tract smooth muscle contraction (GO:0014848)2.84786746
40cell migration in hindbrain (GO:0021535)2.84094951
41regulation of retinoic acid receptor signaling pathway (GO:0048385)2.82515300
42bone trabecula formation (GO:0060346)2.81825148
43exploration behavior (GO:0035640)2.80561222
44maintenance of protein location in nucleus (GO:0051457)2.78585693
45regulation of water loss via skin (GO:0033561)2.77451942
46axon ensheathment in central nervous system (GO:0032291)2.76643949
47central nervous system myelination (GO:0022010)2.76643949
48layer formation in cerebral cortex (GO:0021819)2.72583216
49head development (GO:0060322)2.72151717
50heart trabecula morphogenesis (GO:0061384)2.71974168
51neuronal action potential propagation (GO:0019227)2.69609100
52regulation of synapse assembly (GO:0051963)2.69228021
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68244161
54regulation of telomere maintenance via telomerase (GO:0032210)2.67681692
55apical protein localization (GO:0045176)2.67614032
56startle response (GO:0001964)2.67264591
57cochlea development (GO:0090102)2.64959032
58brain morphogenesis (GO:0048854)2.64300364
59cell proliferation in forebrain (GO:0021846)2.64073991
60neuronal stem cell maintenance (GO:0097150)2.63714908
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63047305
62regulation of response to osmotic stress (GO:0047484)2.62635990
63chromatin assembly (GO:0031497)2.61707801
64lymphangiogenesis (GO:0001946)2.61562315
65regulation of posttranscriptional gene silencing (GO:0060147)2.60323257
66regulation of gene silencing by miRNA (GO:0060964)2.60323257
67regulation of gene silencing by RNA (GO:0060966)2.60323257
68nucleobase catabolic process (GO:0046113)2.59556628
69positive regulation of gastrulation (GO:2000543)2.57947207
70tongue development (GO:0043586)2.57591682
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57390367
72midbrain development (GO:0030901)2.56405629
73spinal cord development (GO:0021510)2.56012658
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54451380
75protein localization to kinetochore (GO:0034501)2.54155348
76neuronal action potential (GO:0019228)2.52258615
77negative regulation of Ras GTPase activity (GO:0034261)2.50053876
78central nervous system neuron axonogenesis (GO:0021955)2.49211040
79hair cycle (GO:0042633)2.49158942
80molting cycle (GO:0042303)2.49158942
81notochord development (GO:0030903)2.48156869
82renal system development (GO:0072001)2.48022699
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47865517
84dopamine biosynthetic process (GO:0042416)2.47164205
85retinal cone cell development (GO:0046549)2.44986923
86ephrin receptor signaling pathway (GO:0048013)2.44431093
87trophectodermal cell differentiation (GO:0001829)2.43247727
88positive regulation of cAMP-mediated signaling (GO:0043950)2.43229667
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42990083
90endothelial cell differentiation (GO:0045446)2.42397882
91hippo signaling (GO:0035329)2.41998642
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40170146
93organ growth (GO:0035265)2.40152335
94camera-type eye morphogenesis (GO:0048593)2.39493470
95protein localization to chromosome, centromeric region (GO:0071459)2.38976521
96hindbrain development (GO:0030902)2.38377524
97synaptic transmission, glutamatergic (GO:0035249)2.38301531
98hemidesmosome assembly (GO:0031581)2.38206266
99ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.38174510
100establishment of monopolar cell polarity (GO:0061162)2.37735641
101establishment or maintenance of monopolar cell polarity (GO:0061339)2.37735641
102regulation of G0 to G1 transition (GO:0070316)2.37673509
103ventricular system development (GO:0021591)2.36927887
104negative regulation of protein localization to cell surface (GO:2000009)2.36423698
105branching involved in mammary gland duct morphogenesis (GO:0060444)2.34871868
106establishment of apical/basal cell polarity (GO:0035089)2.34140366
107mRNA stabilization (GO:0048255)2.32956463
108RNA stabilization (GO:0043489)2.32956463
109cell-cell junction maintenance (GO:0045217)2.32728338
110activin receptor signaling pathway (GO:0032924)2.32144810
111desmosome organization (GO:0002934)2.32085412
112type B pancreatic cell development (GO:0003323)2.30463463
113short-term memory (GO:0007614)2.29339044
114neuron projection extension (GO:1990138)2.29313047
115protein localization to synapse (GO:0035418)2.28199012
116lateral sprouting from an epithelium (GO:0060601)2.27934996
117peptidyl-arginine methylation (GO:0018216)2.26695650
118peptidyl-arginine N-methylation (GO:0035246)2.26695650
119serotonin metabolic process (GO:0042428)2.26253114
120vocalization behavior (GO:0071625)2.25075285
121somite rostral/caudal axis specification (GO:0032525)2.24950279
122mesenchymal to epithelial transition (GO:0060231)2.24789648
123intestinal epithelial cell development (GO:0060576)2.24662254
124behavioral response to ethanol (GO:0048149)2.23250971
125positive regulation of heart growth (GO:0060421)2.23208148
126synapse assembly (GO:0007416)2.23090937
127positive regulation of Rho protein signal transduction (GO:0035025)2.22327863
128eyelid development in camera-type eye (GO:0061029)2.21828768
129retina layer formation (GO:0010842)2.21053195
130regulation of synapse organization (GO:0050807)2.20988637
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.20873966
132neurotransmitter-gated ion channel clustering (GO:0072578)2.20588714
133regulation of clathrin-mediated endocytosis (GO:2000369)2.20447628
134RNA localization (GO:0006403)2.20407477
135nonmotile primary cilium assembly (GO:0035058)2.20398843
136establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.20354868
137central nervous system projection neuron axonogenesis (GO:0021952)2.20144745
138regulation of sensory perception (GO:0051931)2.20082339
139regulation of sensory perception of pain (GO:0051930)2.20082339
140ectoderm development (GO:0007398)2.17561158
141negative regulation of glial cell proliferation (GO:0060253)2.16378769
142keratinization (GO:0031424)2.15104121
143negative regulation of epidermal cell differentiation (GO:0045605)2.13669145
144regulation of cilium movement (GO:0003352)2.12773303
145histone arginine methylation (GO:0034969)2.11930463
146lung-associated mesenchyme development (GO:0060484)2.10933732
147negative regulation of smoothened signaling pathway (GO:0045879)2.09744630
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.08619905
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.08619905
150regulation of translation, ncRNA-mediated (GO:0045974)2.08619905
151sister chromatid segregation (GO:0000819)2.07625437
152mitotic sister chromatid segregation (GO:0000070)2.07374257
153interferon-gamma secretion (GO:0072643)2.07126181
154postsynaptic membrane organization (GO:0001941)2.05587943
155paraxial mesoderm development (GO:0048339)2.03091957
156dendritic spine morphogenesis (GO:0060997)2.02609277
157intracellular estrogen receptor signaling pathway (GO:0030520)2.02287267
158axonal fasciculation (GO:0007413)2.02115538
159axon extension (GO:0048675)2.00257171
160non-canonical Wnt signaling pathway (GO:0035567)2.00238805
161positive regulation of synapse maturation (GO:0090129)2.00046902
162neuron cell-cell adhesion (GO:0007158)1.97328741
163branching involved in labyrinthine layer morphogenesis (GO:0060670)1.96932790
164proline transport (GO:0015824)1.96477206
165negative regulation of telomerase activity (GO:0051974)1.96264358
166peptidyl-arginine omega-N-methylation (GO:0035247)1.95436701
167negative regulation by host of viral transcription (GO:0043922)1.94730421
168negative regulation of activin receptor signaling pathway (GO:0032926)1.94482946
169embryonic camera-type eye development (GO:0031076)1.94432371
170regulation of chromatin binding (GO:0035561)1.94132536
171microtubule severing (GO:0051013)1.93905778
172Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.93161707
173cytoskeletal anchoring at plasma membrane (GO:0007016)1.91835280
174mRNA splice site selection (GO:0006376)1.91802189
175regulation of hair follicle development (GO:0051797)1.91125841
176establishment of tissue polarity (GO:0007164)1.90718301
177establishment of planar polarity (GO:0001736)1.90718301
178nuclear pore complex assembly (GO:0051292)1.90456634
179peptidyl-threonine phosphorylation (GO:0018107)1.90423555
180anterior/posterior axis specification (GO:0009948)1.90330831
181establishment or maintenance of apical/basal cell polarity (GO:0035088)1.90296634
182establishment or maintenance of bipolar cell polarity (GO:0061245)1.90296634
183NLS-bearing protein import into nucleus (GO:0006607)1.90271515
184dorsal/ventral axis specification (GO:0009950)1.89438484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.74496417
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.38442371
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20849240
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.05698985
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.05698985
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.05698985
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.86393857
8GBX2_23144817_ChIP-Seq_PC3_Human2.79678251
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60002787
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.45075975
11EZH2_22144423_ChIP-Seq_EOC_Human2.35626945
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.17488430
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10649894
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09352811
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07466255
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03238090
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03129902
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01620126
19* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99799679
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.95097732
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.94651353
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.94311476
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92404460
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89178928
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88345562
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86210359
27DROSHA_22980978_ChIP-Seq_HELA_Human1.84822941
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80122382
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.79811063
30* KDM2B_26808549_Chip-Seq_K562_Human1.78548274
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70986311
32* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69615012
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67359439
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65818141
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.64037846
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62181429
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61555732
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61464238
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59270648
40* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59002019
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54508735
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53522115
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.50364527
44* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49519475
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47762554
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47757476
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47757476
48KDM2B_26808549_Chip-Seq_DND41_Human1.45111853
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44888281
50PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.44669631
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44485491
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44305380
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.42058496
54TCF7_22412390_ChIP-Seq_EML_Mouse1.41694209
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41586971
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40482320
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40482320
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34072363
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.30379107
60TAF15_26573619_Chip-Seq_HEK293_Human1.30263680
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29874431
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29483758
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.29038783
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28823189
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.28306719
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27877649
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27607088
68TP53_16413492_ChIP-PET_HCT116_Human1.25845811
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25309754
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.24104599
71* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23188165
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23106871
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22405471
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.22381541
75E2F7_22180533_ChIP-Seq_HELA_Human1.21881563
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.21806811
77RNF2_27304074_Chip-Seq_NSC_Mouse1.20861015
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20530920
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.20511193
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.20423587
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.20202146
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19945658
83AR_25329375_ChIP-Seq_VCAP_Human1.19824225
84* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18285463
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18124058
86SMAD4_21799915_ChIP-Seq_A2780_Human1.17934633
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17645941
88ZNF274_21170338_ChIP-Seq_K562_Hela1.15374399
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13667922
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12168072
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.11789841
92POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11645253
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.11571755
94VDR_22108803_ChIP-Seq_LS180_Human1.10310717
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10182018
96* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09421880
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.08328202
98SMAD3_21741376_ChIP-Seq_ESCs_Human1.08160598
99STAT3_23295773_ChIP-Seq_U87_Human1.07206810
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.07164921
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06243183
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05534402
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05206651
104AHR_22903824_ChIP-Seq_MCF-7_Human1.03835128
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.03389961
106MYC_22102868_ChIP-Seq_BL_Human1.03219855
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02990272
108ZNF263_19887448_ChIP-Seq_K562_Human1.02745032
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02594832
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02419384
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00944547
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00821899
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00788322
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.00747603
115* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99044093
116* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99002833
117* KLF5_25053715_ChIP-Seq_YYC3_Human0.98774819
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98701754
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98383394
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98267172
121* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98199337
122RACK7_27058665_Chip-Seq_MCF-7_Human0.98132422
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.97421971
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96968605
125P300_19829295_ChIP-Seq_ESCs_Human0.96871538
126TP53_22127205_ChIP-Seq_IMR90_Human0.96783180
127AR_19668381_ChIP-Seq_PC3_Human0.96630286
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96445380
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96353116
130TCF4_23295773_ChIP-Seq_U87_Human0.95745877
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95035091
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.94716684
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.94653756
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94218103
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.93552158
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93168490
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92337201
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92189053
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92098360
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91081844
141RUNX2_22187159_ChIP-Seq_PCA_Human0.90756251
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90209302
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.89654716
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89435966
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.88707633
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88214719
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.88163636
148STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88160562
149RXR_22108803_ChIP-Seq_LS180_Human0.88119341
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86223363
151CTCF_27219007_Chip-Seq_Bcells_Human0.84866281
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84321318
153REST_21632747_ChIP-Seq_MESCs_Mouse0.84257057
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.84020326
155LXR_22292898_ChIP-Seq_THP-1_Human0.83893873
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.83792667
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83715486
158PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83263985
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82263138
160MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82170229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.19977670
2MP0003880_abnormal_central_pattern3.53163720
3MP0009379_abnormal_foot_pigmentation2.81897207
4MP0004858_abnormal_nervous_system2.59134716
5MP0002254_reproductive_system_inflammat2.44152690
6MP0002735_abnormal_chemical_nociception2.14403851
7MP0003122_maternal_imprinting2.12299032
8MP0009745_abnormal_behavioral_response2.11876661
9MP0001968_abnormal_touch/_nociception2.09442533
10MP0005394_taste/olfaction_phenotype2.08288245
11MP0005499_abnormal_olfactory_system2.08288245
12MP0001986_abnormal_taste_sensitivity2.08033476
13MP0010352_gastrointestinal_tract_polyps2.06400873
14MP0005423_abnormal_somatic_nervous2.05779823
15MP0003941_abnormal_skin_development2.02021064
16MP0002064_seizures2.01269588
17MP0002796_impaired_skin_barrier2.00226696
18MP0003283_abnormal_digestive_organ1.99944150
19MP0002734_abnormal_mechanical_nocicepti1.97512065
20MP0005377_hearing/vestibular/ear_phenot1.97018157
21MP0003878_abnormal_ear_physiology1.97018157
22MP0002063_abnormal_learning/memory/cond1.96550418
23MP0005623_abnormal_meninges_morphology1.90548557
24MP0002272_abnormal_nervous_system1.89813413
25MP0002653_abnormal_ependyma_morphology1.85124909
26MP0001849_ear_inflammation1.84231412
27MP0000383_abnormal_hair_follicle1.78949246
28MP0002572_abnormal_emotion/affect_behav1.75533769
29MP0001486_abnormal_startle_reflex1.69521098
30MP0010234_abnormal_vibrissa_follicle1.66791009
31MP0006276_abnormal_autonomic_nervous1.66031645
32MP0004742_abnormal_vestibular_system1.64538426
33MP0000427_abnormal_hair_cycle1.63635088
34MP0003890_abnormal_embryonic-extraembry1.63252451
35MP0001485_abnormal_pinna_reflex1.60248771
36MP0006292_abnormal_olfactory_placode1.58940780
37MP0003938_abnormal_ear_development1.57548017
38MP0003121_genomic_imprinting1.54986796
39MP0002098_abnormal_vibrissa_morphology1.53509112
40MP0003705_abnormal_hypodermis_morpholog1.53126328
41MP0010678_abnormal_skin_adnexa1.51802162
42MP0002733_abnormal_thermal_nociception1.50499090
43MP0001970_abnormal_pain_threshold1.47908840
44MP0008789_abnormal_olfactory_epithelium1.46582582
45MP0008877_abnormal_DNA_methylation1.46243749
46MP0003136_yellow_coat_color1.43941369
47MP0000049_abnormal_middle_ear1.43888788
48MP0000579_abnormal_nail_morphology1.40805715
49MP0003119_abnormal_digestive_system1.40555782
50MP0000762_abnormal_tongue_morphology1.40248010
51MP0000647_abnormal_sebaceous_gland1.40009113
52MP0002557_abnormal_social/conspecific_i1.39890919
53MP0002736_abnormal_nociception_after1.39417732
54MP0000516_abnormal_urinary_system1.37579618
55MP0005367_renal/urinary_system_phenotyp1.37579618
56MP0003111_abnormal_nucleus_morphology1.36698897
57MP0002089_abnormal_postnatal_growth/wei1.35459666
58MP0004272_abnormal_basement_membrane1.33962884
59MP0003123_paternal_imprinting1.33790221
60MP0001348_abnormal_lacrimal_gland1.32625242
61MP0005646_abnormal_pituitary_gland1.32056734
62MP0004859_abnormal_synaptic_plasticity1.31795340
63MP0004264_abnormal_extraembryonic_tissu1.30633165
64MP0003755_abnormal_palate_morphology1.30173844
65MP0003787_abnormal_imprinting1.29638437
66MP0003385_abnormal_body_wall1.28967909
67MP0004142_abnormal_muscle_tone1.28626166
68MP0002234_abnormal_pharynx_morphology1.27728339
69MP0001346_abnormal_lacrimal_gland1.27274820
70MP0008057_abnormal_DNA_replication1.26863916
71MP0004885_abnormal_endolymph1.26056218
72MP0000778_abnormal_nervous_system1.25691566
73MP0005386_behavior/neurological_phenoty1.24269354
74MP0004924_abnormal_behavior1.24269354
75MP0000428_abnormal_craniofacial_morphol1.23177215
76MP0002233_abnormal_nose_morphology1.22664213
77MP0003942_abnormal_urinary_system1.21650159
78MP0000537_abnormal_urethra_morphology1.20786724
79MP0001502_abnormal_circadian_rhythm1.19942785
80MP0003861_abnormal_nervous_system1.16644978
81MP0001188_hyperpigmentation1.16063837
82MP0002084_abnormal_developmental_patter1.15889255
83MP0002152_abnormal_brain_morphology1.15761939
84MP0001293_anophthalmia1.14530097
85MP0003935_abnormal_craniofacial_develop1.14345642
86MP0000026_abnormal_inner_ear1.13387016
87MP0003315_abnormal_perineum_morphology1.13158224
88MP0000432_abnormal_head_morphology1.12351378
89MP0005257_abnormal_intraocular_pressure1.12170875
90MP0002067_abnormal_sensory_capabilities1.12155577
91MP0003879_abnormal_hair_cell1.11983923
92MP0010030_abnormal_orbit_morphology1.11923501
93MP0001440_abnormal_grooming_behavior1.11736981
94MP0002882_abnormal_neuron_morphology1.11120764
95MP0005501_abnormal_skin_physiology1.09697056
96MP0002116_abnormal_craniofacial_bone1.09260084
97MP0005076_abnormal_cell_differentiation1.08119683
98MP0002085_abnormal_embryonic_tissue1.07316029
99MP0002932_abnormal_joint_morphology1.07162702
100MP0000377_abnormal_hair_follicle1.04357648
101MP0002092_abnormal_eye_morphology1.03963014
102MP0004957_abnormal_blastocyst_morpholog1.03666777
103MP0002751_abnormal_autonomic_nervous1.03444363
104MP0005275_abnormal_skin_tensile1.03200307
105MP0003183_abnormal_peptide_metabolism1.03136276
106MP0000534_abnormal_ureter_morphology1.02445255
107MP0001501_abnormal_sleep_pattern1.02276089
108MP0004270_analgesia1.02005585
109MP0003937_abnormal_limbs/digits/tail_de1.01802318
110MP0001905_abnormal_dopamine_level1.01776660
111MP0009780_abnormal_chondrocyte_physiolo1.00347313
112MP0009278_abnormal_bone_marrow0.99236331
113MP0004197_abnormal_fetal_growth/weight/0.97773399
114MP0002086_abnormal_extraembryonic_tissu0.97550753
115MP0009053_abnormal_anal_canal0.94887078
116MP0002114_abnormal_axial_skeleton0.94614212
117MP0005380_embryogenesis_phenotype0.94357314
118MP0001672_abnormal_embryogenesis/_devel0.94357314
119MP0002102_abnormal_ear_morphology0.93594902
120MP0001286_abnormal_eye_development0.92185482
121MP0001216_abnormal_epidermal_layer0.91887456
122MP0000569_abnormal_digit_pigmentation0.91654109
123MP0002081_perinatal_lethality0.91404127
124MP0005551_abnormal_eye_electrophysiolog0.91004005
125MP0001963_abnormal_hearing_physiology0.90397562
126MP0000350_abnormal_cell_proliferation0.90083184
127MP0002127_abnormal_cardiovascular_syste0.89213162
128MP0002184_abnormal_innervation0.88937375
129MP0009046_muscle_twitch0.88613164
130MP0003566_abnormal_cell_adhesion0.88562094
131MP0004381_abnormal_hair_follicle0.88236757
132MP0004811_abnormal_neuron_physiology0.88168317
133MP0005075_abnormal_melanosome_morpholog0.87439816
134MP0002163_abnormal_gland_morphology0.86350122
135MP0002822_catalepsy0.85537538
136MP0008569_lethality_at_weaning0.85342716
137MP0008770_decreased_survivor_rate0.83052351
138MP0005595_abnormal_vascular_smooth0.82944140
139MP0002066_abnormal_motor_capabilities/c0.82476522
140MP0000678_abnormal_parathyroid_gland0.82348038
141MP0009703_decreased_birth_body0.82040213
142MP0001919_abnormal_reproductive_system0.82029200
143MP0002249_abnormal_larynx_morphology0.81852481
144MP0002177_abnormal_outer_ear0.81817557
145MP0002925_abnormal_cardiovascular_devel0.81619061
146MP0002009_preneoplasia0.81289848
147MP0005508_abnormal_skeleton_morphology0.80363791
148MP0002277_abnormal_respiratory_mucosa0.80035214
149MP0002111_abnormal_tail_morphology0.79723820
150MP0002210_abnormal_sex_determination0.79589485
151MP0002697_abnormal_eye_size0.79397316
152MP0004133_heterotaxia0.79144130
153MP0003943_abnormal_hepatobiliary_system0.78508913
154MP0000955_abnormal_spinal_cord0.78312337
155MP0002088_abnormal_embryonic_growth/wei0.78024959
156MP0000467_abnormal_esophagus_morphology0.77937388
157MP0001324_abnormal_eye_pigmentation0.77874097
158MP0003698_abnormal_male_reproductive0.77423069
159MP0009250_abnormal_appendicular_skeleto0.76853412
160MP0003635_abnormal_synaptic_transmissio0.76613053
161MP0000462_abnormal_digestive_system0.76564954
162MP0010771_integument_phenotype0.75780757
163MP0003984_embryonic_growth_retardation0.75624395
164MP0000631_abnormal_neuroendocrine_gland0.72899923

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.76314220
2Esophageal atresia (HP:0002032)3.99809520
3Focal motor seizures (HP:0011153)3.24171051
4Oligodactyly (hands) (HP:0001180)3.20593997
5Megalencephaly (HP:0001355)3.16751367
6Gastrointestinal atresia (HP:0002589)3.04871373
7Split foot (HP:0001839)3.00436313
8Oligodactyly (HP:0012165)2.94044458
9Bilateral microphthalmos (HP:0007633)2.92091359
10Absent speech (HP:0001344)2.83680257
11Rib fusion (HP:0000902)2.80694042
12Exotropia (HP:0000577)2.73422743
13Limb dystonia (HP:0002451)2.73131793
14Atonic seizures (HP:0010819)2.70668171
15Focal seizures (HP:0007359)2.69411353
16Abnormality of midbrain morphology (HP:0002418)2.50092374
17Molar tooth sign on MRI (HP:0002419)2.50092374
18Aplasia cutis congenita (HP:0001057)2.45503220
19Ependymoma (HP:0002888)2.43453996
20Hypotrichosis (HP:0001006)2.41708046
21Abnormality of incisor morphology (HP:0011063)2.41465039
22Broad metatarsal (HP:0001783)2.40137795
23Pili torti (HP:0003777)2.38985375
24Abnormality of the labia minora (HP:0012880)2.37938289
25Septo-optic dysplasia (HP:0100842)2.37906935
26Supernumerary ribs (HP:0005815)2.36890839
27Renal duplication (HP:0000075)2.36884310
28Myokymia (HP:0002411)2.36607722
29Hepatoblastoma (HP:0002884)2.34663893
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.34470348
31Protruding tongue (HP:0010808)2.33802820
32Clumsiness (HP:0002312)2.31865536
33Slow-growing hair (HP:0002217)2.29678203
34Abnormality of hair growth rate (HP:0011363)2.29678203
35Progressive cerebellar ataxia (HP:0002073)2.28125681
36Patellar aplasia (HP:0006443)2.27548872
37Hypoplastic labia majora (HP:0000059)2.26239026
38Abnormality of the lower motor neuron (HP:0002366)2.18445984
39Supernumerary bones of the axial skeleton (HP:0009144)2.17115519
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15550690
41Short 4th metacarpal (HP:0010044)2.15550690
42Fair hair (HP:0002286)2.14548489
43Concave nail (HP:0001598)2.13186947
44Widely spaced teeth (HP:0000687)2.11505542
45Abnormality of the astrocytes (HP:0100707)2.09967893
46Astrocytoma (HP:0009592)2.09967893
47Broad-based gait (HP:0002136)2.09698753
48Aplasia involving bones of the extremities (HP:0009825)2.09618209
49Aplasia involving bones of the upper limbs (HP:0009823)2.09618209
50Aplasia of the phalanges of the hand (HP:0009802)2.09618209
51Sleep apnea (HP:0010535)2.09352394
52Nephronophthisis (HP:0000090)2.08368649
53Polyphagia (HP:0002591)2.08293826
54Aplasia/Hypoplasia of the patella (HP:0006498)2.08148336
55Obstructive sleep apnea (HP:0002870)2.05825154
56Syringomyelia (HP:0003396)2.05803070
57Spinal cord lesions (HP:0100561)2.05803070
58Conical tooth (HP:0000698)2.05612516
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.01319270
60Anterior segment dysgenesis (HP:0007700)1.99994984
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.97904370
62Absent/shortened dynein arms (HP:0200106)1.97904370
63Milia (HP:0001056)1.97145739
64Preauricular pit (HP:0004467)1.96963260
65Periauricular skin pits (HP:0100277)1.96963260
66Shallow orbits (HP:0000586)1.96722017
67Nephroblastoma (Wilms tumor) (HP:0002667)1.93841254
68Humeroradial synostosis (HP:0003041)1.92949873
69Synostosis involving the elbow (HP:0003938)1.92949873
70Hypoplastic nipples (HP:0002557)1.92945973
71Abnormal respiratory epithelium morphology (HP:0012253)1.90935075
72Abnormal respiratory motile cilium morphology (HP:0005938)1.90935075
73Coronal craniosynostosis (HP:0004440)1.90836893
74Preaxial foot polydactyly (HP:0001841)1.90318195
75Optic nerve hypoplasia (HP:0000609)1.89910147
76Neurofibrillary tangles (HP:0002185)1.89198190
77Large earlobe (HP:0009748)1.89084072
78Volvulus (HP:0002580)1.89066692
79Abnormality of the labia majora (HP:0012881)1.87464008
80Abnormality of nail color (HP:0100643)1.87293373
81Bifid tongue (HP:0010297)1.86725165
82Asymmetry of the thorax (HP:0001555)1.86179783
83Thickened helices (HP:0000391)1.85608433
84Embryonal renal neoplasm (HP:0011794)1.83662779
85Inability to walk (HP:0002540)1.83161854
86Dialeptic seizures (HP:0011146)1.81683290
87Abnormality of the incisor (HP:0000676)1.81508018
88Bronchomalacia (HP:0002780)1.81497159
89Generalized tonic-clonic seizures (HP:0002069)1.80851275
90Cerebral inclusion bodies (HP:0100314)1.79445802
91Neoplasm of the oral cavity (HP:0100649)1.79312021
92Abnormality of the intervertebral disk (HP:0005108)1.78961672
93Colon cancer (HP:0003003)1.77653908
94Abnormality of the renal medulla (HP:0100957)1.76573097
95Abnormality of the corticospinal tract (HP:0002492)1.76516531
96Neoplasm of striated muscle (HP:0009728)1.76155408
97Chronic hepatic failure (HP:0100626)1.75225818
98Abnormality of the diencephalon (HP:0010662)1.75042628
99Skin pits (HP:0100276)1.74662418
100Maternal diabetes (HP:0009800)1.74498187
101Vitreoretinal degeneration (HP:0000655)1.73793544
102Epileptic encephalopathy (HP:0200134)1.72278697
103Cupped ear (HP:0000378)1.72098535
104Shawl scrotum (HP:0000049)1.71773532
105Abnormality of the pubic bones (HP:0003172)1.71704673
106Abnormal eating behavior (HP:0100738)1.71521681
107Fragile nails (HP:0001808)1.70942972
108Genu recurvatum (HP:0002816)1.70449435
109Glioma (HP:0009733)1.70344613
110Apathy (HP:0000741)1.70302940
111Drooling (HP:0002307)1.70217656
112Abnormality of secondary sexual hair (HP:0009888)1.70215007
113Abnormality of the axillary hair (HP:0100134)1.70215007
114Pachygyria (HP:0001302)1.68836360
115Enlarged penis (HP:0000040)1.68377629
116Abnormality of permanent molar morphology (HP:0011071)1.67152359
117Abnormality of the dental root (HP:0006486)1.67152359
118Taurodontia (HP:0000679)1.67152359
119Abnormality of the phalanges of the hallux (HP:0010057)1.67019551
120Vertebral fusion (HP:0002948)1.67003491
121Ventricular fibrillation (HP:0001663)1.66887402
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66796876
123True hermaphroditism (HP:0010459)1.66716176
124Rectal fistula (HP:0100590)1.66418461
125Rectovaginal fistula (HP:0000143)1.66418461
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66309728
127Stereotypic behavior (HP:0000733)1.66225164
128Absence seizures (HP:0002121)1.65797730
129Sparse scalp hair (HP:0002209)1.65735424
130Atrioventricular canal defect (HP:0006695)1.65446255
131Medulloblastoma (HP:0002885)1.64742582
132Abnormal lung lobation (HP:0002101)1.62826657
133Amyotrophic lateral sclerosis (HP:0007354)1.62355051
134Arnold-Chiari malformation (HP:0002308)1.62269384
135Atrophic scars (HP:0001075)1.62233861
136Labial hypoplasia (HP:0000066)1.62132103
137Natal tooth (HP:0000695)1.61317085
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.60826787
139Selective tooth agenesis (HP:0001592)1.60666997
140Curly hair (HP:0002212)1.59244452
141Neoplasm of the heart (HP:0100544)1.59132401
142Woolly hair (HP:0002224)1.58445002
143Fused cervical vertebrae (HP:0002949)1.58184425
144Supernumerary spleens (HP:0009799)1.56593780
145Overriding aorta (HP:0002623)1.56499462
146Intestinal fistula (HP:0100819)1.56170711
147Abnormality of the 4th metacarpal (HP:0010012)1.55366448
148Morphological abnormality of the middle ear (HP:0008609)1.54157822
149Amblyopia (HP:0000646)1.53595417
150Partial duplication of the phalanx of hand (HP:0009999)1.53411324
151Anomalous pulmonary venous return (HP:0010772)1.53058241
152Malignant gastrointestinal tract tumors (HP:0006749)1.50399226
153Gastrointestinal carcinoma (HP:0002672)1.50399226
154Short humerus (HP:0005792)1.49723642
155Upper limb muscle weakness (HP:0003484)1.49487561
156Febrile seizures (HP:0002373)1.49416207
157Abnormality of the pulmonary veins (HP:0011718)1.48645334
158Partial duplication of thumb phalanx (HP:0009944)1.48407704
159Hemiparesis (HP:0001269)1.47354577
160Aplasia/hypoplasia of the humerus (HP:0006507)1.46805695
161Malignant neoplasm of the central nervous system (HP:0100836)1.45369050
162Abnormality of chromosome segregation (HP:0002916)1.45266512
163Abnormality of the salivary glands (HP:0010286)1.44656127
164Missing ribs (HP:0000921)1.43652267
165Increased nuchal translucency (HP:0010880)1.42871582
166Short 5th finger (HP:0009237)1.41890886
167Genetic anticipation (HP:0003743)1.41819606
168Chromosomal breakage induced by crosslinking agents (HP:0003221)1.41818655
169Atresia of the external auditory canal (HP:0000413)1.40159157
170Hyperacusis (HP:0010780)1.40069795
171Buphthalmos (HP:0000557)1.39891542
172Abnormal ventriculo-arterial connection (HP:0011563)1.38656724
173Transposition of the great arteries (HP:0001669)1.38656724
174Abnormal connection of the cardiac segments (HP:0011545)1.38656724
175Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.37635111
176Abnormality of the musculature of the hand (HP:0001421)1.36875359
177Premature rupture of membranes (HP:0001788)1.36433889
178Rhabdomyosarcoma (HP:0002859)1.36034421
179Abnormality of the aortic arch (HP:0012303)1.35598991
180Dislocated radial head (HP:0003083)1.35187426
181Dysphonia (HP:0001618)1.34914975
182Heterotopia (HP:0002282)1.34900553
183Short phalanx of the thumb (HP:0009660)1.34798153
184Skin tags (HP:0010609)1.34722600
185Open mouth (HP:0000194)1.34485457
186Facial cleft (HP:0002006)1.34421804
187Diminished motivation (HP:0000745)1.34332006
188Fibrous tissue neoplasm (HP:0012316)1.33439473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.23789802
2CDK125.68048151
3CASK4.48781870
4TLK13.61138125
5GRK53.04556776
6MARK12.72656241
7TYRO32.69173313
8MAP3K102.65002590
9TNIK2.50473646
10GRK62.47358044
11ICK2.43940485
12MATK2.00472254
13LATS11.87140010
14EPHA21.81560308
15LATS21.74149747
16SIK21.68837349
17MAP3K51.66121648
18MAP3K91.60932941
19NTRK21.54792878
20FRK1.53803031
21MARK21.51679543
22NTRK31.50677819
23TTK1.48397600
24RIPK11.46900179
25ALK1.46761792
26TGFBR21.44972809
27CDK191.42702727
28CAMK1G1.37685029
29WNK11.36299353
30PNCK1.35109234
31GRK11.32710074
32GRK71.32220936
33SGK21.29511199
34MKNK21.28004228
35NTRK11.27759896
36PDGFRA1.25975992
37DDR21.25408276
38WNK31.24193404
39HIPK21.21464864
40KSR11.18184522
41PRKCI1.17407576
42STK101.16161300
43EPHB21.16114655
44AKT31.15888206
45DAPK21.15743258
46EEF2K1.15464322
47CDK71.11382487
48CAMK1D1.06741368
49SGK4941.03708274
50SGK2231.03708274
51IRAK21.01864480
52MAPK71.01831153
53CHEK21.01103254
54EPHB11.00773165
55PAK40.97633010
56STK30.97127706
57OXSR10.95422554
58STK110.94302535
59PRKCZ0.94028571
60MAP4K20.93233064
61CLK10.91838115
62TAF10.91342133
63TRIB30.90916618
64SIK10.90752533
65ERN10.90087141
66PTK20.88311548
67PRKCG0.88021662
68TAOK10.86365407
69MAPKAPK30.84259332
70MTOR0.83636193
71MKNK10.82734672
72UHMK10.81122445
73CAMK40.81016442
74RPS6KA20.80563996
75BMX0.80036145
76CDK60.78602279
77ADRBK20.78558901
78EPHA40.78182830
79CSNK1A1L0.76924181
80STK390.76624309
81SGK30.75000716
82PIK3CA0.74590542
83NME10.73801324
84FGR0.73184563
85MINK10.72868958
86DYRK30.69035278
87PTK60.68950189
88PINK10.68883811
89MAP3K20.68412824
90CDK80.68076934
91STK380.67759177
92PAK60.65027793
93MAP2K60.64901910
94TGFBR10.64671389
95PTK2B0.63411270
96TRIM280.62806736
97CSF1R0.62628376
98NEK20.61719476
99DYRK20.60950607
100DMPK0.59142253
101SGK10.58834845
102ADRBK10.58711961
103CAMK10.58199758
104PLK10.58189887
105CDK20.57894674
106NUAK10.55816710
107CHEK10.54901026
108AKT20.54700726
109KSR20.54332347
110TAOK30.53246565
111CDK50.53233611
112PDGFRB0.52329340
113RIPK40.52167092
114PKN10.51827141
115PRKD20.51604861
116MELK0.51111840
117RET0.50809744
118PRKD30.49380484
119MAPK80.48891203
120CDK30.48758808
121BMPR1B0.48705165
122ERBB20.48308850
123FGFR20.47950950
124MAPK100.47198253
125GSK3B0.46713512
126PRKCE0.46592917
127CDK40.46413515
128MAPK120.46301414
129MET0.46009777
130YES10.45146409
131CSNK1E0.45079861
132CDK11A0.44487699
133FGFR30.44100109
134DYRK1A0.43611702
135STK240.42430167
136ATM0.41946024
137CAMK2B0.41471149
138CDK150.40915351
139PRKG10.40749218
140CSNK1D0.40256975
141CDK140.39277934
142WNK40.39215942
143FER0.38884906
144MARK30.38421502
145MAPK130.38358151
146CDK10.38068526
147MAP3K70.38052367
148MAPK90.36713645
149ERBB30.36159625
150MAP2K40.35431337
151MAP3K80.35312016
152CDK180.34776774
153MAPK150.33910087
154PLK40.33693201
155PAK20.33684222
156MAPK140.33595218
157PLK20.32116807

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17233022
2Basal cell carcinoma_Homo sapiens_hsa052171.67699437
3Hedgehog signaling pathway_Homo sapiens_hsa043401.62908137
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55521809
5Hippo signaling pathway_Homo sapiens_hsa043901.48562570
6Axon guidance_Homo sapiens_hsa043601.48052566
7Linoleic acid metabolism_Homo sapiens_hsa005911.43463521
8Insulin secretion_Homo sapiens_hsa049111.41265324
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39374219
10Dorso-ventral axis formation_Homo sapiens_hsa043201.35211220
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31181951
12Long-term potentiation_Homo sapiens_hsa047201.28691935
13Phototransduction_Homo sapiens_hsa047441.28190295
14mRNA surveillance pathway_Homo sapiens_hsa030151.26687676
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26269622
16Wnt signaling pathway_Homo sapiens_hsa043101.25266193
17Ether lipid metabolism_Homo sapiens_hsa005651.24882907
18Endometrial cancer_Homo sapiens_hsa052131.17062823
19Colorectal cancer_Homo sapiens_hsa052101.14853730
20Glioma_Homo sapiens_hsa052141.13491995
21Melanogenesis_Homo sapiens_hsa049161.12698810
22Ovarian steroidogenesis_Homo sapiens_hsa049131.12513133
23VEGF signaling pathway_Homo sapiens_hsa043701.10044732
24MicroRNAs in cancer_Homo sapiens_hsa052061.09789008
25ErbB signaling pathway_Homo sapiens_hsa040121.09201399
26Long-term depression_Homo sapiens_hsa047301.08924287
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.06601966
28Nicotine addiction_Homo sapiens_hsa050331.06454598
29Notch signaling pathway_Homo sapiens_hsa043301.04468485
30Vitamin B6 metabolism_Homo sapiens_hsa007501.04400722
31Estrogen signaling pathway_Homo sapiens_hsa049151.02785084
32Glutamatergic synapse_Homo sapiens_hsa047241.02603345
33Renal cell carcinoma_Homo sapiens_hsa052111.01760723
34Chronic myeloid leukemia_Homo sapiens_hsa052201.01390031
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01338276
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.00124880
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00065997
38Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99500813
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.99087448
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98723267
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98464711
42GnRH signaling pathway_Homo sapiens_hsa049120.98437900
43Adherens junction_Homo sapiens_hsa045200.97346792
44mTOR signaling pathway_Homo sapiens_hsa041500.97039332
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95377128
46Tight junction_Homo sapiens_hsa045300.94932015
47Non-small cell lung cancer_Homo sapiens_hsa052230.94169040
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93710835
49Choline metabolism in cancer_Homo sapiens_hsa052310.93404040
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92535213
51Pathways in cancer_Homo sapiens_hsa052000.91923143
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.91686217
53Taste transduction_Homo sapiens_hsa047420.91619827
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91347659
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89198567
56Serotonergic synapse_Homo sapiens_hsa047260.88828529
57Olfactory transduction_Homo sapiens_hsa047400.88236869
58Proteoglycans in cancer_Homo sapiens_hsa052050.88022230
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87339038
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87299804
61Rap1 signaling pathway_Homo sapiens_hsa040150.87281522
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86647044
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85274437
64Renin secretion_Homo sapiens_hsa049240.84917006
65Oocyte meiosis_Homo sapiens_hsa041140.83791268
66Gap junction_Homo sapiens_hsa045400.83173462
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82644556
68Dopaminergic synapse_Homo sapiens_hsa047280.82455892
69MAPK signaling pathway_Homo sapiens_hsa040100.82389738
70Focal adhesion_Homo sapiens_hsa045100.82241000
71Prolactin signaling pathway_Homo sapiens_hsa049170.82238458
72Thyroid cancer_Homo sapiens_hsa052160.81958722
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81317645
74Small cell lung cancer_Homo sapiens_hsa052220.81251773
75ECM-receptor interaction_Homo sapiens_hsa045120.81110198
76Amphetamine addiction_Homo sapiens_hsa050310.81096640
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79517553
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79383362
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78953351
80Acute myeloid leukemia_Homo sapiens_hsa052210.78897610
81Cell cycle_Homo sapiens_hsa041100.78358884
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78237765
83Oxytocin signaling pathway_Homo sapiens_hsa049210.77862724
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76742323
85Inositol phosphate metabolism_Homo sapiens_hsa005620.76532105
86Prostate cancer_Homo sapiens_hsa052150.75162636
87Pancreatic secretion_Homo sapiens_hsa049720.74594637
88GABAergic synapse_Homo sapiens_hsa047270.73937967
89HTLV-I infection_Homo sapiens_hsa051660.73930085
90Ras signaling pathway_Homo sapiens_hsa040140.73482671
91Pancreatic cancer_Homo sapiens_hsa052120.72611735
92Nitrogen metabolism_Homo sapiens_hsa009100.72149004
93Salivary secretion_Homo sapiens_hsa049700.71870868
94Circadian entrainment_Homo sapiens_hsa047130.71582576
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71309620
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69874204
97TGF-beta signaling pathway_Homo sapiens_hsa043500.69683980
98Basal transcription factors_Homo sapiens_hsa030220.68823079
99Regulation of autophagy_Homo sapiens_hsa041400.68713827
100Cholinergic synapse_Homo sapiens_hsa047250.68692879
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68633350
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.68076729
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67968024
104cAMP signaling pathway_Homo sapiens_hsa040240.67365947
105Bladder cancer_Homo sapiens_hsa052190.67263588
106Morphine addiction_Homo sapiens_hsa050320.67156436
107Type II diabetes mellitus_Homo sapiens_hsa049300.66740901
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66691495
109Melanoma_Homo sapiens_hsa052180.66460139
110RNA transport_Homo sapiens_hsa030130.66120216
111Cocaine addiction_Homo sapiens_hsa050300.65960092
112T cell receptor signaling pathway_Homo sapiens_hsa046600.63224083
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.62525558
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62081415
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61784823
116Gastric acid secretion_Homo sapiens_hsa049710.61557620
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61226415
118Chemokine signaling pathway_Homo sapiens_hsa040620.61196731
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60544938
120Circadian rhythm_Homo sapiens_hsa047100.60397832
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.60070484
122Calcium signaling pathway_Homo sapiens_hsa040200.59907319
123Synaptic vesicle cycle_Homo sapiens_hsa047210.59838524
124FoxO signaling pathway_Homo sapiens_hsa040680.59041335
125Platelet activation_Homo sapiens_hsa046110.58030860
126Thyroid hormone synthesis_Homo sapiens_hsa049180.57878681
127Collecting duct acid secretion_Homo sapiens_hsa049660.52460365
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52236452
129Sphingolipid metabolism_Homo sapiens_hsa006000.51576440
130Cardiac muscle contraction_Homo sapiens_hsa042600.50730908

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